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Phillip Sharp

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Jeremy E Wilusz; Phillip A Sharp
Molecular biology. A circuitous route to noncoding RNA.
Allan M Gurtan; Courtney K Jnbaptiste; Peter B Rahl; Arvind Ravi; Arjun Bhutkar; Andrew D Bosson; Charles A Whittaker; Richard A Young; Phillip A Sharp
Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts.
Alla A Sigova; Albert E Almada; Cosmas C Giallourakis; Matthew G Guenther; Sumeet Gupta; Charles Lin; Benoit Molinie; Alan C Mullen; David A Orlando; Phillip A Sharp; Richard A Young
Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells.

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All Publications

2013: Jeremy E Wilusz; Phillip A Sharp
Molecular biology. A circuitous route to noncoding RNA.
Science (New York, N.Y.) 2013;340(6131):440-1.
2013: Allan M Gurtan; Courtney K Jnbaptiste; Peter B Rahl; Arvind Ravi; Arjun Bhutkar; Andrew D Bosson; Charles A Whittaker; Richard A Young; Phillip A Sharp
Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts.
Genes & development 2013;27(8):941-54.
2013: Alla A Sigova; Albert E Almada; Cosmas C Giallourakis; Matthew G Guenther; Sumeet Gupta; Charles Lin; Benoit Molinie; Alan C Mullen; David A Orlando; Phillip A Sharp; Richard A Young
Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(8):2876-81.
2013: Anthony K L Leung; Phillip A Sharp
Quantifying Argonaute proteins in and out of GW/P-bodies: implications in microRNA activities.
Advances in experimental medicine and biology 2013;768():165-82.
2012: Jeremy E Wilusz; Courtney K JnBaptiste; Leemor Joshua-Tor; Claus-D Kuhn; Laura Y Lu; Phillip A Sharp
A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails.
Genes & development 2012;26(21):2392-407.
2012: Arvind Ravi; Arjun Bhutkar; Christine Chin; Allan M Gurtan; Tyler Jacks; Madhu S Kumar; Jacqueline A Lees; Victoria Lu; Phillip A Sharp
Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1.
Cancer cell 2012;21(6):848-55.
2012: Allan M Gurtan; Victoria Lu; Arjun Bhutkar; Phillip A Sharp
In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs.
RNA (New York, N.Y.) 2012;18(6):1116-22.
2012: Margaret S Ebert; Phillip A Sharp
Roles for microRNAs in conferring robustness to biological processes.
Cell 2012;149(3):515-24.
2012: Michael S Goldberg; Phillip A Sharp
Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression.
The Journal of experimental medicine 2012;209(2):217-24.
2011: Jeremy E Wilusz; Joseph M Whipple; Eric M Phizicky; Phillip A Sharp
tRNAs marked with CCACCA are targeted for degradation.
Science (New York, N.Y.) 2011;334(6057):817-21.
2011: Grace X Y Zheng; Christopher B Burge; Genevieve M Gould; Arvind Ravi; Phillip A Sharp
Genome-wide impact of a recently expanded microRNA cluster in mouse.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(38):15804-9.
2011: Shankar Mukherji; Phillip A Sharp; John S Tsang; Margaret S Ebert; Grace X Y Zheng; Alexander van Oudenaarden
MicroRNAs can generate thresholds in target gene expression.
Nature genetics 2011;43(9):854-9.
2011: Lea A Medeiros; David C Page; Phillip A Sharp; Amy C White; Lucas M Dennis; Dongdong Fu; Mark E Gill; Hristo Houbaviy; Oktay Kirak; Styliani Markoulaki; Rudolf Jaenisch
Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(34):14163-8.
2011: Phillip A Sharp; Robert Langer
Research agenda. Promoting convergence in biomedical science.
Science (New York, N.Y.) 2011;333(6042):527.
2011: Ryan A Flynn; Albert E Almada; Jesse R Zamudio; Phillip A Sharp
Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(26):10460-5.
2011: Marc W Kirschner; Harley McAdams; Lucy Shapiro; Phillip A Sharp; Richard A Young; Genevieve Almouzni; Uri Alon
Fifty years after Jacob and Monod: what are the unanswered questions in molecular biology?
Molecular cell 2011;42(4):403-4.
2011: Leung Anthony; Sejal Vyas; Jennifer E Rood; Arjun Bhutkar; Phillip A Sharp; Paul Chang
Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm.
Molecular cell 2011;42(4):489-99.
2011: Grace X Y Zheng; Arvind Ravi; J Mauro Calabrese; Lea A Medeiros; Oktay Kirak; Lucas M Dennis; Rudolf Jaenisch; Christopher B Burge; Phillip A Sharp
A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells.
PLoS genetics 2011;7(5):e1002054.
2011: Leung Anthony; Amanda G Young; Arjun Bhutkar; Grace X Zheng; Andrew D Bosson; Cydney B Nielsen; Phillip A Sharp
Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs.
Nature structural & molecular biology 2011;18(2):237-44.
2011: Michael S Goldberg; Deyin Xing; Yin Ren; Sandra Orsulic; Sangeeta N Bhatia; Phillip A Sharp
Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(2):745-50.
2010: Menno P Creyghton; Albert W Cheng; G Grant Welstead; Tristan Kooistra; Bryce W Carey; Eveline J Steine; Jacob Hanna; Michael A Lodato; Garrett M Frampton; Phillip A Sharp; Laurie A Boyer; Richard A Young; Rudolf Jaenisch
Histone H3K27ac separates active from poised enhancers and predicts developmental state.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21931-6.
2010: Leung Anthony; Phillip A Sharp
MicroRNA functions in stress responses.
Molecular cell 2010;40(2):205-15.
2010: Margaret S Ebert; Phillip A Sharp
Emerging roles for natural microRNA sponges.
Current biology : CB 2010;20(19):R858-61.
2010: Neetu Singh; Amit Agrawal; Leung Anthony; Phillip A Sharp; Sangeeta N Bhatia
Effect of nanoparticle conjugation on gene silencing by RNA interference.
Journal of the American Chemical Society 2010;132(24):8241-3.
2010: Peter B Rahl; Charles Y Lin; Amy C Seila; Ryan A Flynn; Scott McCuine; Christopher B Burge; Phillip A Sharp; Richard A Young
c-Myc regulates transcriptional pause release.
Cell 2010;141(3):432-45.
2010: Dieter Edbauer; Joel R Neilson; Kelly A Foster; Chi-Fong Wang; Daniel P Seeburg; Matthew N Batterton; Tomoko Tada; Bridget M Dolan; Phillip A Sharp; Morgan Sheng
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132.
Neuron 2010;65(3):373-84.
2009: Amit Agrawal; Dal-Hee Min; Neetu Singh; Haihao Zhu; Alona Birjiniuk; Geoffrey von Maltzahn; Todd J Harris; Deyin Xing; Stephen D Woolfenden; Phillip A Sharp; Alain Charest; Sangeeta Bhatia
Functional delivery of siRNA in mice using dendriworms.
ACS nano 2009;3(9):2495-504.
2009: Amy C Seila; Leighton J Core; John T Lis; Phillip A Sharp
Divergent transcription: a new feature of active promoters.
Cell cycle (Georgetown, Tex.) 2009;8(16):2557-64.
2009: Daniel Kleppner; Phillip A Sharp
Research data in the digital age.
Science (New York, N.Y.) 2009;325(5939):368.
2009: Phillip A Sharp
The centrality of RNA.
Cell 2009;136(4):577-80.
2008: Joel R Neilson; Phillip A Sharp
Small RNA regulators of gene expression.
Cell 2008;134(6):899-902.
2008: Patrick Stern; Sophie Astrof; Stefan J Erkeland; Joshua Schustak; Phillip A Sharp; Richard O Hynes
A system for Cre-regulated RNA interference in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(37):13895-900.
2008: Alexander Marson; Stuart S Levine; Megan F Cole; Garrett M Frampton; Tobias Brambrink; Sarah E Johnstone; Matthew G Guenther; Wendy K Johnston; Marius Wernig; Jamie Newman; J Mauro Calabrese; Lucas M Dennis; Thomas L Volkert; Sumeet Gupta; Jennifer Love; Nancy M Hannett; Phillip A Sharp; David P Bartel; Rudolf Jaenisch; Richard A Young
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells.
Cell 2008;134(3):521-33.
2008: Rickard Sandberg; Joel R Neilson; Arup Sarma; Phillip A Sharp; Christopher B Burge
Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites.
Science (New York, N.Y.) 2008;320(5883):1643-7.
2008: Amy C Seila; Phillip A Sharp
Small RNAs tell big stories in Whistler.
Nature cell biology 2008;10(6):630-3.
2008: Madhu S Kumar; Stefan J Erkeland; Ryan E Pester; Cindy Y Chen; Margaret S Ebert; Phillip A Sharp; Tyler Jacks
Suppression of non-small cell lung tumor development by the let-7 microRNA family.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3903-8.
2008: Andrea Ventura; Amanda G Young; Monte M Winslow; Laura Lintault; Alexander Meissner; Stefan J Erkeland; Jamie Newman; Roderick T Bronson; Denise Crowley; James R Stone; Rudolf Jaenisch; Phillip A Sharp; Tyler Jacks
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters.
Cell 2008;132(5):875-86.
2007: J Mauro Calabrese; Amy C Seila; Gene Yeo; Phillip A Sharp
RNA sequence analysis defines Dicer's role in mouse embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(46):18097-102.
2007: Margaret S Ebert; Joel R Neilson; Phillip A Sharp
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells.
Nature methods 2007;4(9):721-6.
2007: Leung Anthony; Phillip A Sharp
microRNAs: a safeguard against turmoil?
Cell 2007;130(4):581-5.
2007: Caroline Schild-Poulter; A Shih; Dean Tantin; N C Yarymowich; Sébastien Soubeyrand; Phillip A Sharp; Robert J G Haché
DNA-PK phosphorylation sites on Oct-1 promote cell survival following DNA damage.
Oncogene 2007;26(27):3980-8.
2007: Erik W Wilker; Marcel A T M van Vugt; Steven A Artim; Paul H. Huang; Christian P. Petersen; H Christian Reinhardt; Yun Feng; Phillip A Sharp; Nahum Sonenberg; Forest M White; Michael B Yaffe
14-3-3sigma controls mitotic translation to facilitate cytokinesis.
Nature 2007;446(7133):329-32.
2007: Joel R Neilson; Grace X Y Zheng; Christopher B Burge; Phillip A Sharp
Dynamic regulation of miRNA expression in ordered stages of cellular development.
Genes & development 2007;21(5):578-89.
2007: Lourdes M Alemán; John G Doench; Phillip A Sharp
Comparison of siRNA-induced off-target RNA and protein effects.
RNA (New York, N.Y.) 2007;13(3):385-95.
2007: Robert Harriman; Phillip A Sharp; Michael Leavitt; John E Niederhuber
Investiture of John E. Niederhuber, M.D., director of National Cancer Institute.
The oncologist 2007;12(2):136-41.
2007: Haoquan Wu; Joel R Neilson; Priti Kumar; Monika Manocha; Premlata Shankar; Phillip A Sharp; N Manjunath
miRNA profiling of naïve, effector and memory CD8 T cells.
PloS one 2007;2(10):e1020.
2006: J Mauro Calabrese; Phillip A Sharp
Characterization of the short RNAs bound by the P19 suppressor of RNA silencing in mouse embryonic stem cells.
RNA (New York, N.Y.) 2006;12(12):2092-102.
2006: Leung Anthony; J Mauro Calabrese; Phillip A Sharp
Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(48):18125-30.
2006: Shweta Hakre; Maria Isabel Tussie-Luna; Todd Ashworth; Carl D Novina; Jeffrey Settleman; Phillip A Sharp; Ananda L Roy
Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression.
Molecular cell 2006;24(2):301-8.
2006: Chonghui Cheng; Michael B Yaffe; Phillip A Sharp
A positive feedback loop couples Ras activation and CD44 alternative splicing.
Genes & development 2006;20(13):1715-20.
2006: Frank Miskevich; John G Doench; Matthew T Townsend; Phillip A Sharp; Martha Constantine-Paton
RNA interference of Xenopus NMDAR NR1 in vitro and in vivo.
Journal of neuroscience methods 2006;152(1-2):65-73.
2006: Christian P. Petersen; Marie-Eve Bordeleau; Jerry Pelletier; Phillip A Sharp
Short RNAs repress translation after initiation in mammalian cells.
Molecular cell 2006;21(4):533-42.
2006: Leung Anthony; Phillip A Sharp
Function and localization of microRNAs in mammalian cells.
Cold Spring Harbor symposia on quantitative biology 2006;71():29-38.
2006: Chonghui Cheng; Phillip A Sharp
Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion.
Molecular and cellular biology 2006;26(1):362-70.
2005: Dean Tantin; Caroline Schild-Poulter; Victoria Wang; Robert J G Haché; Phillip A Sharp
The octamer binding transcription factor Oct-1 is a stress sensor.
Cancer research 2005;65(23):10750-8.
2005: Alla Grishok; Phillip A Sharp
Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(48):17360-5.
2005: Phillip A Sharp
1918 flu and responsible science.
Science (New York, N.Y.) 2005;310(5745):17.
2005: Jeong-Ho Hong; Eun Sook Hwang; Michael McManus; Adam Amsterdam; Yu Tian; Ralitsa Kalmukova; Elisabetta Mueller; Thomas Benjamin; Bruce M Spiegelman; Phillip A Sharp; Nancy Hopkins; Michael B Yaffe
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.
Science (New York, N.Y.) 2005;309(5737):1074-8.
2005: Hristo B Houbaviy; Lucas Dennis; Rudolf Jaenisch; Phillip A Sharp
Characterization of a highly variable eutherian microRNA gene.
RNA (New York, N.Y.) 2005;11(8):1245-57.
2005: Phillip A Sharp
The discovery of split genes and RNA splicing.
Trends in biochemical sciences 2005;30(6):279-81.
2005: Joel R Neilson; Phillip A Sharp
Herpesviruses throw a curve ball: new insights into microRNA biogenesis and evolution.
Nature methods 2005;2(4):252-4.
2005: Alla Grishok; Jina L Sinskey; Phillip A Sharp
Transcriptional silencing of a transgene by RNAi in the soma of C. elegans.
Genes & development 2005;19(6):683-96.
2005: Phillip A Sharp
Phillip Sharp discusses RNAi, Nobel Prizes and entrepreneurial science.
Drug discovery today 2005;10(1):7-10.
2004: Keng Boon Lee; Phillip A Sharp
Transcription-dependent polyubiquitination of RNA polymerase II requires lysine 63 of ubiquitin.
Biochemistry 2004;43(48):15223-9.
2004: Jennifer H Mansfield; Brian D Harfe; Robert Nissen; John Obenauer; Jalagani Srineel; Aadel Chaudhuri; Raphael Farzan-Kashani; Michael Zuker; Amy E Pasquinelli; Gary Ruvkun; Phillip A Sharp; Clifford J Tabin; Michael McManus
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression.
Nature genetics 2004;36(10):1079-83.
2004: William G Fairbrother; Dirk Holste; Christopher B Burge; Phillip A Sharp
Single nucleotide polymorphism-based validation of exonic splicing enhancers.
PLoS biology 2004;2(9):E268.
2004: Andrea Ventura; Alexander Meissner; Christopher P Dillon; Michael McManus; Phillip A Sharp; Luk Van Parijs; Rudolf Jaenisch; Tyler Jacks
Cre-lox-regulated conditional RNA interference from transgenes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(28):10380-5.
2004: Carl D Novina; Phillip A Sharp
The RNAi revolution.
Nature 2004;430(6996):161-4.
2004: William G Fairbrother; Gene Yeo; Rufang Yeh; Paul Goldstein; Matthew Mawson; Phillip A Sharp; Christopher B Burge
RESCUE-ESE identifies candidate exonic splicing enhancers in vertebrate exons.
Nucleic acids research 2004;32(Web Server issue):W187-90.
2004: John G Doench; Phillip A Sharp
Specificity of microRNA target selection in translational repression.
Genes & development 2004;18(5):504-11.
2004: Victoria E H Wang; Dean Tantin; Jianzhu Chen; Phillip A Sharp
B cell development and immunoglobulin transcription in Oct-1-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2005-10.
2004: Dean Tantin; Maria Isabel Tussie-Luna; Ananda L Roy; Phillip A Sharp
Regulation of immunoglobulin promoter activity by TFII-I class transcription factors.
The Journal of biological chemistry 2004;279(7):5460-9.
2004: Mauricio L Nogueira; Victoria E H Wang; Dean Tantin; Phillip A Sharp; Thomas M Kristie
Herpes simplex virus infections are arrested in Oct-1-deficient cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(6):1473-8.
2004: Victoria E H Wang; Tara Schmidt; Jianzhu Chen; Phillip A Sharp; Dean Tantin
Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice.
Molecular and cellular biology 2004;24(3):1022-32.
2003: Hristo B Houbaviy; Michael F Murray; Phillip A Sharp
Embryonic stem cell-specific MicroRNAs.
Developmental cell 2003;5(2):351-8.
2003: Erwei Song; Sang-Kyung Lee; Derek M. Dykxhoorn; Carl D Novina; Dong Zhang; Keith Crawford; Jan Cerny; Phillip A Sharp; Judy Lieberman; N Manjunath; Premlata Shankar
Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages.
Journal of virology 2003;77(13):7174-81.
2003: Derek M. Dykxhoorn; Carl D Novina; Phillip A Sharp
Killing the messenger: short RNAs that silence gene expression.
Nature reviews. Molecular cell biology 2003;4(6):457-67.
2003: Sheila A Stewart; Derek M. Dykxhoorn; Deborah Palliser; Hana Mizuno; Evan Y Yu; Dong Sung An; David M Sabatini; Irvin S Y Chen; William C Hahn; Phillip A Sharp; Robert A. Weinberg; Carl D Novina
Lentivirus-delivered stable gene silencing by RNAi in primary cells.
RNA (New York, N.Y.) 2003;9(4):493-501.
2003: Qing Ge; Michael McManus; Tam Nguyen; Ching-Hung Shen; Phillip A Sharp; Herman N Eisen; Jianzhu Chen
RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2718-23.
2003: Chonghui Cheng; Phillip A Sharp
RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and gamma-actin genes.
Molecular and cellular biology 2003;23(6):1961-7.
2003: John G Doench; Christian P. Petersen; Phillip A Sharp
siRNAs can function as miRNAs.
Genes & development 2003;17(4):438-42.
2002: Michael McManus; Brian B Haines; Christopher P Dillon; Charles E Whitehurst; Luk Van Parijs; Jianzhu Chen; Phillip A Sharp
Small interfering RNA-mediated gene silencing in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5754-60.
2002: Michael McManus; Phillip A Sharp
Gene silencing in mammals by small interfering RNAs.
Nature reviews. Genetics 2002;3(10):737-47.
2002: William G Fairbrother; Rufang Yeh; Phillip A Sharp; Christopher B Burge
Predictive identification of exonic splicing enhancers in human genes.
Science (New York, N.Y.) 2002;297(5583):1007-13.
2002: Rebecca B Scarr; Phillip A Sharp
PDCD2 is a negative regulator of HCF-1 (C1).
Oncogene 2002;21(34):5245-54.
2002: Carl D Novina; Michael F Murray; Derek M. Dykxhoorn; Paul J Beresford; Jonathan Riess; Sang-Kyung Lee; Ronald G Collman; Judy Lieberman; Premlata Shankar; Phillip A Sharp
siRNA-directed inhibition of HIV-1 infection.
Nature medicine 2002;8(7):681-6.
2002: Michael McManus; Christian P. Petersen; Brian B Haines; Jianzhu Chen; Phillip A Sharp
Gene silencing using micro-RNA designed hairpins.
RNA (New York, N.Y.) 2002;8(6):842-50.
2002: Keng-Boon Lee; Dong Wang; Stephen J Lippard; Phillip A Sharp
Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4239-44.
2002: Dean Tantin; Phillip A Sharp
Mouse lymphoid cell line selected to have high immunoglobulin promoter activity.
Molecular and cellular biology 2002;22(5):1460-73.
2001: J B Kim; Phillip A Sharp
Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.
The Journal of biological chemistry 2001;276(15):12317-23.
2001: Phillip A Sharp
RNA interference--2001.
Genes & development 2001;15(5):485-90.
2001: K J Arrow; Julius Axelrod; franccesca villella; P Berg; John M Bishop; N Bloembergen; Herbert C Brown; J Cibelli; S Cohen; L N Cooper; E J Corey; J W Cronin; Robert F Curl; R Dulbecco; E H Fischer; V L Fitch; Robert W Fogel; J I Friedman; R F Furchgott; M Gell-Mann; W Gilbert; A Gilman; D Glaser; S L Glashow; R M Green; Paul Greengard; Roger Guillemin; L Hayflick; Herbert A Hauptman; J J Heckman; Alan J Heeger; Dudley R Herschbach; David H Hubel; R Hulse; Eric R Kandel; Jerome Karle; L R Klein; W Kohn; A Kornberg; Edwin G Krebs; R P Lanza; R Laughlin; L Lederman; D M Lee; E Lewis; William N Lipscomb; R A Marcus; D McFadden; RB Merrifield; R Merton; F Modigliani; M J Molina; F Murad; Marshall Nirenberg; D C North; George A Olah; D Osheroff; GE Palade; M Perl; N F Ramsey; B Richter; Richard J Roberts; P A Samuelson; M Schwartz; Phillip A Sharp; Richard E Smalley; Hamilton O Smith; R M Solow; H Stormer; H Taube; R Taylor; ED Thomas; J Tobin; Susumu Tonegawa; C Townes; James D Watson; S Weinberg; T H Weller; M D West; Eric Wieschaus; Torsten N Wiesel; R W Wilson
Nobel laureates' letter to President Bush.
Washington post (Washington, D.C. : 1974) 2001;():A02.
2001: K Chen; Q Liu; L Xie; Phillip A Sharp; Daniel I C Wang
Engineering of a mammalian cell line for reduction of lactate formation and high monoclonal antibody production.
Biotechnology and bioengineering 2001;72(1):55-61.
2001: T Tuschl; Phillip A Sharp; David P Bartel
A ribozyme selected from variants of U6 snRNA promotes 2',5'-branch formation.
RNA (New York, N.Y.) 2001;7(1):29-43.
2000: Phillip A Sharp
View of life sciences in the 21st century.
Journal of dermatological science 2000;24 Suppl 1():S1-14.
2000: S L Gilbert; J R Pehrson; Phillip A Sharp
XIST RNA associates with specific regions of the inactive X chromatin.
The Journal of biological chemistry 2000;275(47):36491-4.
2000: S M Berget; C Moore; Phillip A Sharp
Spliced segments at the 5' terminus of adenovirus 2 late mRNA. 1977.
Reviews in medical virology 2000;10(6):356-62; discussion 355-6.
2000: R B Scarr; M R Smith; M Beddall; Phillip A Sharp
A novel 50-kilodalton fragment of host cell factor 1 (C1) in G(0) cells.
Molecular and cellular biology 2000;20(10):3568-75.
2000: Phillip D Zamore; Thomas Tuschl; Phillip A Sharp; David P Bartel
RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals.
Cell 2000;101(1):25-33.
2000: Phillip A Sharp; Phillip D Zamore
Molecular biology. RNA interference.
Science (New York, N.Y.) 2000;287(5462):2431-3.
2000: Benjamin J Blencowe; G Baurén; AG Eldridge; R Issner; Jeffrey A Nickerson; Emanuel Rosonina; Phillip A Sharp
The SRm160/300 splicing coactivator subunits.
RNA (New York, N.Y.) 2000;6(1):111-20.
1999: Thomas Tuschl; Phillip D Zamore; R Lehmann; David P Bartel; Phillip A Sharp
Targeted mRNA degradation by double-stranded RNA in vitro.
Genes & development 1999;13(24):3191-7.
1999: P S Page-McCaw; K Amonlirdviman; Phillip A Sharp
PUF60: a novel U2AF65-related splicing activity.
RNA (New York, N.Y.) 1999;5(12):1548-60.
1999: S L Gilbert; Phillip A Sharp
Promoter-specific hypoacetylation of X-inactivated genes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(24):13825-30.
1999: H Tang; Phillip A Sharp
Transcriptional regulation of the murine 3' IgH enhancer by OCT-2.
Immunity 1999;11(5):517-26.
1999: D Chasman; K Cepek; Phillip A Sharp; Carl O Pabo
Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface.
Genes & development 1999;13(20):2650-7.
1999: J B Kim; Y Yamaguchi; T Wada; H Handa; Phillip A Sharp
Tat-SF1 protein associates with RAP30 and human SPT5 proteins.
Molecular and cellular biology 1999;19(9):5960-8.
1999: AG Eldridge; Yazhou Li; Phillip A Sharp; Benjamin J Blencowe
The SRm160/300 splicing coactivator is required for exon-enhancer function.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6125-30.
1999: A Mitsui; Phillip A Sharp
Ubiquitination of RNA polymerase II large subunit signaled by phosphorylation of carboxyl-terminal domain.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6054-9.
1999: Phillip A Sharp
RNAi and double-strand RNA.
Genes & development 1999;13(2):139-41.
1998: Christopher B Burge; R A Padgett; Phillip A Sharp
Evolutionary fates and origins of U12-type introns.
Molecular cell 1998;2(6):773-85.
1998: Lee P Lim; Phillip A Sharp
Alternative splicing of the fibronectin EIIIB exon depends on specific TGCATG repeats.
Molecular and cellular biology 1998;18(7):3900-6.
1998: T Tuschl; Phillip A Sharp; David P Bartel
Selection in vitro of novel ribozymes from a partially randomized U2 and U6 snRNA library.
The EMBO journal 1998;17(9):2637-50.
1998: Benjamin J Blencowe; R Issner; Jeffrey A Nickerson; Phillip A Sharp
A coactivator of pre-mRNA splicing.
Genes & development 1998;12(7):996-1009.
1997: Phillip A Sharp; Christopher B Burge
Classification of introns: U2-type or U12-type.
Cell 1997;91(7):875-9.
1997: Grace Jones; Phillip A Sharp
Ultraspiracle: an invertebrate nuclear receptor for juvenile hormones.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13499-503.
1997: Charles C Query; P S McCaw; Phillip A Sharp
A minimal spliceosomal complex A recognizes the branch site and polypyrimidine tract.
Molecular and cellular biology 1997;17(5):2944-53.
1997: J S Kim; J Kim; K L Cepek; Phillip A Sharp; Carl O Pabo
Design of TATA box-binding protein/zinc finger fusions for targeted regulation of gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3616-20.
1997: B M Shykind; J Kim; L Stewart; J J Champoux; Phillip A Sharp
Topoisomerase I enhances TFIID-TFIIA complex assembly during activation of transcription.
Genes & development 1997;11(3):397-407.
1997: A M MacMillan; P S McCaw; J D Crispino; Phillip A Sharp
SC35-mediated reconstitution of splicing in U2AF-depleted nuclear extract.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):133-6.
1996: Q Zhou; Phillip A Sharp
Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.
Science (New York, N.Y.) 1996;274(5287):605-10.
1996: K L Cepek; D I Chasman; Phillip A Sharp
Sequence-specific DNA binding of the B-cell-specific coactivator OCA-B.
Genes & development 1996;10(16):2079-88.
1996: S E Harper; Y Qiu; Phillip A Sharp
Sin3 corepressor function in Myc-induced transcription and transformation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8536-40.
1996: M J Mortillaro; B J Blencowe; X Wei; H Nakayasu; L Du; SL Warren; Phillip A Sharp; Ronald Berezney
A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8253-7.
1996: J Kim; Jeffrey D Parvin; B M Shykind; Phillip A Sharp
A negative cofactor containing Dr1/p19 modulates transcription with TFIIA in a promoter-specific fashion.
The Journal of biological chemistry 1996;271(31):18405-12.
1996: J D Crispino; J E Mermoud; Angus I Lamond; Phillip A Sharp
Cis-acting elements distinct from the 5' splice site promote U1-independent pre-mRNA splicing.
RNA (New York, N.Y.) 1996;2(7):664-73.
1996: Charles C Query; Scott A Strobel; Phillip A Sharp
Three recognition events at the branch-site adenine.
The EMBO journal 1996;15(6):1392-402.
1995: JOEL POMERANTZ; Carl O Pabo; Phillip A Sharp
Analysis of homeodomain function by structure-based design of a transcription factor.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9752-6.
1995: Benjamin J Blencowe; R Issner; J Kim; P Mccaw; Phillip A Sharp
New proteins related to the Ser-Arg family of splicing factors.
RNA (New York, N.Y.) 1995;1(8):852-65.
1995: J D Crispino; Phillip A Sharp
A U6 snRNA:pre-mRNA interaction can be rate-limiting for U1-independent splicing.
Genes & development 1995;9(18):2314-23.
1995: B M Shykind; J Kim; Phillip A Sharp
Activation of the TFIID-TFIIA complex with HMG-2.
Genes & development 1995;9(11):1354-65.
1995: Tomi Mäkelä; Jeffrey D Parvin; J Kim; L J Huber; Phillip A Sharp; Robert A. Weinberg
A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5174-8.
1995: Thomas M Kristie; JOEL POMERANTZ; T C Twomey; S A Parent; Phillip A Sharp
The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides.
The Journal of biological chemistry 1995;270(9):4387-94.
1995: Jeffrey D Parvin; R J McCormick; Phillip A Sharp; David E Fisher
Pre-bending of a promoter sequence enhances affinity for the TATA-binding factor.
Nature 1995;373(6516):724-7.
1995: Q Zhou; Phillip A Sharp
Novel mechanism and factor for regulation by HIV-1 Tat.
The EMBO journal 1995;14(2):321-8.
1995: JOEL POMERANTZ; Phillip A Sharp; Carl O Pabo
Structure-based design of transcription factors.
Science (New York, N.Y.) 1995;267(5194):93-6.
1995: Charles C Query; Scott A Strobel; Phillip A Sharp
The branch site adenosine is recognized differently for the two steps of pre-mRNA splicing.
Nucleic acids symposium series 1995;(33):224-5.
1994: A M MacMillan; Charles C Query; C R Allerson; S Chen; Gregory L Verdine; Phillip A Sharp
Dynamic association of proteins with the pre-mRNA branch region.
Genes & development 1994;8(24):3008-20.
1994: Benjamin J Blencowe; Jeffrey A Nickerson; R Issner; Sheldon Penman; Phillip A Sharp
Association of nuclear matrix antigens with exon-containing splicing complexes.
The Journal of cell biology 1994;127(3):593-607.
1994: J D Crispino; Benjamin J Blencowe; Phillip A Sharp
Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNP.
Science (New York, N.Y.) 1994;265(5180):1866-9.
1994: JOEL POMERANTZ; Phillip A Sharp
Homeodomain determinants of major groove recognition.
Biochemistry 1994;33(36):10851-8.
1994: Jeffrey D Parvin; B M Shykind; R E Meyers; J Kim; Phillip A Sharp
Multiple sets of basal factors initiate transcription by RNA polymerase II.
The Journal of biological chemistry 1994;269(28):18414-21.
1994: Phillip A Sharp
Split genes and RNA splicing.
Cell 1994;77(6):805-15.
1994: Charles C Query; M J Moore; Phillip A Sharp
Branch nucleophile selection in pre-mRNA splicing: evidence for the bulged duplex model.
Genes & development 1994;8(5):587-97.
1994: William C Aird; Jeffrey D Parvin; Phillip A Sharp; R D Rosenberg
The interaction of GATA-binding proteins and basal transcription factors with GATA box-containing core promoters. A model of tissue-specific gene expression.
The Journal of biological chemistry 1994;269(2):883-9.
1993: R E Meyers; Phillip A Sharp
TATA-binding protein and associated factors in polymerase II and polymerase III transcription.
Molecular and cellular biology 1993;13(12):7953-60.
1993: M J Moore; Phillip A Sharp
Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing.
Nature 1993;365(6444):364-8.
1993: D A Potter; C J Larson; P Eckes; R M Schmid; Gary Nabel; Gregory L Verdine; Phillip A Sharp
Purification of the major histocompatibility complex class I transcription factor H2TF1. The full-length product of the nfkb2 gene.
The Journal of biological chemistry 1993;268(25):18882-90.
1993: D I Chasman; K M Flaherty; Phillip A Sharp; Roger D Kornberg
Crystal structure of yeast TATA-binding protein and model for interaction with DNA.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(17):8174-8.
1993: Jørgen Kjems; Phillip A Sharp
The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly.
Journal of virology 1993;67(8):4769-76.
1993: A Srebrow; Andrés F Muro; Santiago E Werbajh; Phillip A Sharp; Alberto R Kornblihtt
The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter.
FEBS letters 1993;327(1):25-8.
1993: Jeffrey D Parvin; Phillip A Sharp
DNA topology and a minimal set of basal factors for transcription by RNA polymerase II.
Cell 1993;73(3):533-40.
1993: Thomas M Kristie; Phillip A Sharp
Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16).
The Journal of biological chemistry 1993;268(9):6525-34.
1993: David E Fisher; L A Parent; Phillip A Sharp
High affinity DNA-binding Myc analogs: recognition by an alpha helix.
Cell 1993;72(3):467-76.
1992: David E Fisher; L A Parent; Phillip A Sharp
Myc/Max and other helix-loop-helix/leucine zipper proteins bend DNA toward the minor groove.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):11779-83.
1992: JOEL POMERANTZ; Thomas M Kristie; Phillip A Sharp
Recognition of the surface of a homeo domain protein.
Genes & development 1992;6(11):2047-57.
1992: K P LeClair; M A Blanar; Phillip A Sharp
The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):8145-9.
1992: H T Timmers; R E Meyers; Phillip A Sharp
Composition of transcription factor B-TFIID.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):8140-4.
1992: Daniel A Haber; H T Timmers; J Pelletier; Phillip A Sharp; David E Housman
A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):6010-4.
1992: M J Moore; Phillip A Sharp
Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites.
Science (New York, N.Y.) 1992;256(5059):992-7.
1992: Jeffrey D Parvin; H T Timmers; Phillip A Sharp
Promoter specificity of basal transcription factors.
Cell 1992;68(6):1135-44.
1992: Phillip A Sharp
TATA-binding protein is a classless factor.
Cell 1992;68(5):819-21.
1992: J Kjems; B J Calnan; Alan D Frankel; Phillip A Sharp
Specific binding of a basic peptide from HIV-1 Rev.
The EMBO journal 1992;11(3):1119-29.
1991: Jeffrey D Parvin; Phillip A Sharp
Identification of novel factors which bind specifically to the core promoter of the immunoglobulin heavy chain gene.
The Journal of biological chemistry 1991;266(34):22878-86.
1991: Robert Marciniak; Phillip A Sharp
HIV-1 Tat protein promotes formation of more-processive elongation complexes.
The EMBO journal 1991;10(13):4189-96.
1991: David E Fisher; C S Carr; L A Parent; Phillip A Sharp
TFEB has DNA-binding and oligomerization properties of a unique helix-loop-helix/leucine-zipper family.
Genes & development 1991;5(12A):2342-52.
1991: Phillip A Sharp
"Five easy pieces".
Science (New York, N.Y.) 1991;254(5032):663.
1991: H T Timmers; Phillip A Sharp
The mammalian TFIID protein is present in two functionally distinct complexes.
Genes & development 1991;5(11):1946-56.
1991: J Kjems; Alan D Frankel; Phillip A Sharp
Specific regulation of mRNA splicing in vitro by a peptide from HIV-1 Rev.
Cell 1991;67(1):169-78.
1991: Stephen Buratowski; M Sopta; Jack Greenblatt; Phillip A Sharp
RNA polymerase II-associated proteins are required for a DNA conformation change in the transcription initiation complex.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(17):7509-13.
1991: Y Zhang; J Babin; A L Feldhaus; H Singh; Phillip A Sharp; Minou Bina
HTF4: a new human helix-loop-helix protein.
Nucleic acids research 1991;19(16):4555.
1991: A Gil; Phillip A Sharp; S F Jamison; Mariano A Garcia-Blanco
Characterization of cDNAs encoding the polypyrimidine tract-binding protein.
Genes & development 1991;5(7):1224-36.
1991: Phillip A Sharp
Gene transcription. TFIIB or not TFIIB?
Nature 1991;351(6321):16-8.
1991: AJ Buckler; D D Chang; Sharon L Graw; J David Brook; Daniel A Haber; Phillip A Sharp; David E Housman
Exon amplification: a strategy to isolate mammalian genes based on RNA splicing.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):4005-9.
1991: James R Flanagan; M Murata; P A Burke; Y Shirayoshi; E Appella; Phillip A Sharp; Keiko Ozato
Negative regulation of the major histocompatibility complex class I promoter in embryonal carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3145-9.
1991: J Kjems; Myles Brown; D D Chang; Phillip A Sharp
Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the Rev response element.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):683-7.
1990: Thomas M Kristie; Phillip A Sharp
Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV alpha-trans-activator protein.
Genes & development 1990;4(12B):2383-96.
1990: Robert Marciniak; B J Calnan; Alan D Frankel; Phillip A Sharp
HIV-1 Tat protein trans-activates transcription in vitro.
Cell 1990;63(4):791-802.
1990: M M Konarska; Phillip A Sharp
Structure of RNAs replicated by the DNA-dependent T7 RNA polymerase.
Cell 1990;63(3):609-18.
1990: S Buratowski; Phillip A Sharp
Transcription initiation complexes and upstream activation with RNA polymerase II lacking the C-terminal domain of the largest subunit.
Molecular and cellular biology 1990;10(10):5562-4.
1990: Phillip A Sharp
The crisis in funding: a time for decisions.
Cell 1990;62(5):839-40.
1990: D D Chang; Phillip A Sharp
Messenger RNA transport and HIV rev regulation.
Science (New York, N.Y.) 1990;249(4969):614-5.
1990: C S Carr; Phillip A Sharp
A helix-loop-helix protein related to the immunoglobulin E box-binding proteins.
Molecular and cellular biology 1990;10(8):4384-8.
1990: Myles Brown; Phillip A Sharp
Human estrogen receptor forms multiple protein-DNA complexes.
The Journal of biological chemistry 1990;265(19):11238-43.
1990: Robert Marciniak; Mariano A Garcia-Blanco; Phillip A Sharp
Identification and characterization of a HeLa nuclear protein that specifically binds to the trans-activation-response (TAR) element of human immunodeficiency virus.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(9):3624-8.
1990: Mariano A Garcia-Blanco; G J Anderson; J Beggs; Phillip A Sharp
A mammalian protein of 220 kDa binds pre-mRNAs in the spliceosome: a potential homologue of the yeast PRP8 protein.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):3082-6.
1990: A S Baldwin; K P LeClair; H Singh; Phillip A Sharp
A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes.
Molecular and cellular biology 1990;10(4):1406-14.
1989: Thomas M Kristie; J H LeBowitz; Phillip A Sharp
The octamer-binding proteins form multi-protein--DNA complexes with the HSV alpha TIF regulatory protein.
The EMBO journal 1989;8(13):4229-38.
1989: D D Chang; Phillip A Sharp
Regulation by HIV Rev depends upon recognition of splice sites.
Cell 1989;59(5):789-95.
1989: Lowell E Schnipper; V Chan; J Sedivy; P Jat; Phillip A Sharp
Gene activation by induced DNA rearrangements.
Cancer research 1989;49(23):6640-4.
1989: M A García-Blanco; S F Jamison; Phillip A Sharp
Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns.
Genes & development 1989;3(12A):1874-86.
1989: S Hahn; S Buratowski; Phillip A Sharp; Leonard Guarente
Identification of a yeast protein homologous in function to the mammalian general transcription factor, TFIIA.
The EMBO journal 1989;8(11):3379-82.
1989: Phillip A Sharp; Robert Marciniak
HIV TAR: an RNA enhancer?
Cell 1989;59(2):229-30.
1989: Nancy R Manley; M A O'Connell; Phillip A Sharp; Nancy Hopkins
Nuclear factors that bind to the enhancer region of nondefective Friend murine leukemia virus.
Journal of virology 1989;63(10):4210-23.
1989: J H LeBowitz; R G Clerc; Michael Brenowitz; Phillip A Sharp
The Oct-2 protein binds cooperatively to adjacent octamer sites.
Genes & development 1989;3(10):1625-38.
1989: S Hahn; S Buratowski; Phillip A Sharp; L Guarente
Isolation of the gene encoding the yeast TATA binding protein TFIID: a gene identical to the SPT15 suppressor of Ty element insertions.
Cell 1989;58(6):1173-81.
1989: F A Laski; S Ganguly; Phillip A Sharp; U L RajBhandary; Gerald M Rubin
Construction, stable transformation, and function of an amber suppressor tRNA gene in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6696-8.
1989: S Hahn; S Buratowski; Phillip A Sharp; Leonard Guarente
Yeast TATA-binding protein TFIID binds to TATA elements with both consensus and nonconsensus DNA sequences.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5718-22.
1989: M A García-Blanco; R G Clerc; Phillip A Sharp
The DNA-binding homeo domain of the Oct-2 protein.
Genes & development 1989;3(6):739-45.
1989: M M Konarska; Phillip A Sharp
Replication of RNA by the DNA-dependent RNA polymerase of phage T7.
Cell 1989;57(3):423-31.
1989: Phillip A Sharp
Gene regulation and oncogenes. AACR special conference in cancer research. American Association for Cancer Research.
Cancer research 1989;49(8):2188-94.
1989: P S Jat; Phillip A Sharp
Cell lines established by a temperature-sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature.
Molecular and cellular biology 1989;9(4):1672-81.
1989: M A Blanar; Albert S Baldwin; R A Flavell; Phillip A Sharp
A gamma-interferon-induced factor that binds the interferon response sequence of the MHC class I gene, H-2Kb.
The EMBO journal 1989;8(4):1139-44.
1989: S Buratowski; S Hahn; Leonard Guarente; Phillip A Sharp
Five intermediate complexes in transcription initiation by RNA polymerase II.
Cell 1989;56(4):549-61.
1989: Lewis A Chodosh; Andrew Fire; M Samuels; Phillip A Sharp
5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro.
The Journal of biological chemistry 1989;264(4):2250-7.
1989: Lewis A Chodosh; S Buratowski; Phillip A Sharp
A yeast protein possesses the DNA-binding properties of the adenovirus major late transcription factor.
Molecular and cellular biology 1989;9(2):820-2.
1989: J M Sedivy; Phillip A Sharp
Positive genetic selection for gene disruption in mammalian cells by homologous recombination.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(1):227-31.
1988: R G Clerc; L M Corcoran; J H LeBowitz; David Baltimore; Phillip A Sharp
The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.
Genes & development 1988;2(12A):1570-81.
1988: Winship Herr; R A Sturm; R G Clerc; L M Corcoran; David Baltimore; Phillip A Sharp; H A Ingraham; M G Rosenfeld; M Finney; Gary Ruvkun
The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.
Genes & development 1988;2(12A):1513-6.
1988: Phillip A Sharp
RNA splicing and genes.
JAMA : the journal of the American Medical Association 1988;260(20):3035-41.
1988: R W Carthew; M Samuels; Phillip A Sharp
Formation of transcription preinitiation complexes with an amanitin-resistant RNA polymerase II.
The Journal of biological chemistry 1988;263(32):17128-35.
1988: J H LeBowitz; T Kobayashi; L Staudt; David Baltimore; Phillip A Sharp
Octamer-binding proteins from B or HeLa cells stimulate transcription of the immunoglobulin heavy-chain promoter in vitro.
Genes & development 1988;2(10):1227-37.
1988: M M Konarska; Phillip A Sharp
Association of U2, U4, U5, and U6 small nuclear ribonucleoproteins in a spliceosome-type complex in absence of precursor RNA.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(15):5459-62.
1988: L M Staudt; R G Clerc; H Singh; J H LeBowitz; Phillip A Sharp; David Baltimore
Cloning of a lymphoid-specific cDNA encoding a protein binding the regulatory octamer DNA motif.
Science (New York, N.Y.) 1988;241(4865):577-80.
1988: S Buratowski; S Hahn; Phillip A Sharp; Leonard Guarente
Function of a yeast TATA element-binding protein in a mammalian transcription system.
Nature 1988;334(6177):37-42.
1988: A Virtanen; Phillip A Sharp
Processing at immunoglobulin polyadenylation sites in lymphoid cell extracts.
The EMBO journal 1988;7(5):1421-9.
1988: Lewis A Chodosh; A S Baldwin; R W Carthew; Phillip A Sharp
Human CCAAT-binding proteins have heterologous subunits.
Cell 1988;53(1):11-24.
1988: Lewis A Chodosh; J Olesen; S Hahn; A S Baldwin; Leonard Guarente; Phillip A Sharp
A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable.
Cell 1988;53(1):25-35.
1988: H Watanabe; T Imai; Phillip A Sharp; H Handa
Identification of two transcription factors that bind to specific elements in the promoter of the adenovirus early-region 4.
Molecular and cellular biology 1988;8(3):1290-300.
1988: H Singh; J H LeBowitz; A S Baldwin; Phillip A Sharp
Molecular cloning of an enhancer binding protein: isolation by screening of an expression library with a recognition site DNA.
Cell 1988;52(3):415-23.
1988: A S Baldwin; Phillip A Sharp
Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(3):723-7.
1988: J Weinberger; P S Jat; Phillip A Sharp
Localization of a repressive sequence contributing to B-cell specificity in the immunoglobulin heavy-chain enhancer.
Molecular and cellular biology 1988;8(2):988-92.
1988: David J Shapiro; Phillip A Sharp; W W Wahli; M J Keller
A high-efficiency HeLa cell nuclear transcription extract.
DNA (Mary Ann Liebert, Inc.) 1988;7(1):47-55.
1988: S Ganguly; Phillip A Sharp; Uttam L RajBhandary
Saccharomyces cerevisiae SUP53 tRNA gene transcripts are processed by mammalian cell extracts in vitro but are not processed in vivo.
Molecular and cellular biology 1988;8(1):361-70.
1988: Angus I Lamond; M M Konarska; P J Grabowski; Phillip A Sharp
Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(2):411-5.
1988: C L Moore; H Skolnik-David; Phillip A Sharp
Sedimentation analysis of polyadenylation-specific complexes.
Molecular and cellular biology 1988;8(1):226-33.
1987: Phillip A Sharp; D Eisenberg
The evolution of catalytic function.
Science (New York, N.Y.) 1987;238(4828):729-30, 807.
1987: R W Carthew; Lewis A Chodosh; Phillip A Sharp
The major late transcription factor binds to and activates the mouse metallothionein I promoter.
Genes & development 1987;1(9):973-80.
1987: Lewis A Chodosh; R W Carthew; J G Morgan; Gerald R Crabtree; Phillip A Sharp
The adenovirus major late transcription factor activates the rat gamma-fibrinogen promoter.
Science (New York, N.Y.) 1987;238(4827):684-8.
1987: H Skolnik-David; C L Moore; Phillip A Sharp
Electrophoretic separation of polyadenylation-specific complexes.
Genes & development 1987;1(7):672-82.
1987: Angus I Lamond; M M Konarska; Phillip A Sharp
A mutational analysis of spliceosome assembly: evidence for splice site collaboration during spliceosome formation.
Genes & development 1987;1(6):532-43.
1987: J M Sedivy; J P Capone; U L RajBhandary; Phillip A Sharp
An inducible mammalian amber suppressor: propagation of a poliovirus mutant.
Cell 1987;50(3):379-89.
1987: Phillip A Sharp
Trans splicing: variation on a familiar theme?
Cell 1987;50(2):147-8.
1987: S Hanaka; T Nishigaki; Phillip A Sharp; H Handa
Regulation of in vitro and in vivo transcription of early-region IV of adenovirus type 5 by multiple cis-acting elements.
Molecular and cellular biology 1987;7(7):2578-87.
1987: M M Konarska; Phillip A Sharp
Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes.
Cell 1987;49(6):763-74.
1987: Phillip A Sharp
Biology, oncology, and RNA splicing.
Cancer 1987;59(10):1697-708.
1987: K L Berkner; Brian Schaffhausen; Thomas M Roberts; Phillip A Sharp
Abundant expression of polyomavirus middle T antigen and dihydrofolate reductase in an adenovirus recombinant.
Journal of virology 1987;61(4):1213-20.
1987: Phillip A Sharp
Splicing of messenger RNA precursors.
Science (New York, N.Y.) 1987;235(4790):766-71.
1987: A S Baldwin; Phillip A Sharp
Binding of a nuclear factor to a regulatory sequence in the promoter of the mouse H-2Kb class I major histocompatibility gene.
Molecular and cellular biology 1987;7(1):305-13.
1987: Phillip A Sharp; M M Konarksa; P J Grabowski; Angus I Lamond; Robert Marciniak; S R Seiler
Splicing of messenger RNA precursors.
Cold Spring Harbor symposia on quantitative biology 1987;52():277-85.
1986: Lewis A Chodosh; R W Carthew; Phillip A Sharp
A single polypeptide possesses the binding and transcription activities of the adenovirus major late transcription factor.
Molecular and cellular biology 1986;6(12):4723-33.
1986: L M Staudt; H Singh; RANJAN SEN; T Wirth; Phillip A Sharp; David Baltimore
A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes.
Nature 1986;323(6089):640-3.
1986: P J Grabowski; Phillip A Sharp
Affinity chromatography of splicing complexes: U2, U5, and U4 + U6 small nuclear ribonucleoprotein particles in the spliceosome.
Science (New York, N.Y.) 1986;233(4770):1294-9.
1986: M M Konarska; Phillip A Sharp
Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs.
Cell 1986;46(6):845-55.
1986: J P Capone; J M Sedivy; Phillip A Sharp; U L RajBhandary
Introduction of UAG, UAA, and UGA nonsense mutations at a specific site in the Escherichia coli chloramphenicol acetyltransferase gene: use in measurement of amber, ochre, and opal suppression in mammalian cells.
Molecular and cellular biology 1986;6(9):3059-67.
1986: P S Jat; Phillip A Sharp
Large T antigens of simian virus 40 and polyomavirus efficiently establish primary fibroblasts.
Journal of virology 1986;59(3):746-50.
1986: J Weinberger; David Baltimore; Phillip A Sharp
Distinct factors bind to apparently homologous sequences in the immunoglobulin heavy-chain enhancer.
Nature 1986;322(6082):846-8.
1986: C L Moore; H Skolnik-David; Phillip A Sharp
Analysis of RNA cleavage at the adenovirus-2 L3 polyadenylation site.
The EMBO journal 1986;5(8):1929-38.
1986: P S Jat; C L Cepko; R C Mulligan; Phillip A Sharp
Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens.
Molecular and cellular biology 1986;6(4):1204-17.
1986: Y D Choi; P J Grabowski; Phillip A Sharp; G Dreyfuss
Heterogeneous nuclear ribonucleoproteins: role in RNA splicing.
Science (New York, N.Y.) 1986;231(4745):1534-9.
1986: M Samuels; Phillip A Sharp
Purification and characterization of a specific RNA polymerase II transcription factor.
The Journal of biological chemistry 1986;261(5):2003-13.
1986: H Singh; RANJAN SEN; David Baltimore; Phillip A Sharp
A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes.
Nature 1986;319(6049):154-8.
1986: R A Padgett; P J Grabowski; M M Konarska; S Seiler; Phillip A Sharp
Splicing of messenger RNA precursors.
Annual review of biochemistry 1986;55():1119-50.
1985: R W Carthew; Lewis A Chodosh; Phillip A Sharp
An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter.
Cell 1985;43(2 Pt 1):439-48.
1985: R A Padgett; M M Konarska; M Aebi; H Hornig; C Weissmann; Phillip A Sharp
Nonconsensus branch-site sequences in the in vitro splicing of transcripts of mutant rabbit beta-globin genes.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(24):8349-53.
1985: Phillip A Sharp
On the origin of RNA splicing and introns.
Cell 1985;42(2):397-400.
1985: M M Konarska; R A Padgett; Phillip A Sharp
Trans splicing of mRNA precursors in vitro.
Cell 1985;42(1):165-71.
1985: P J Grabowski; S R Seiler; Phillip A Sharp
A multicomponent complex is involved in the splicing of messenger RNA precursors.
Cell 1985;42(1):345-53.
1985: C L Moore; Phillip A Sharp
Accurate cleavage and polyadenylation of exogenous RNA substrate.
Cell 1985;41(3):845-55.
1985: R E Kingston; A S Baldwin; Phillip A Sharp
Transcription control by oncogenes.
Cell 1985;41(1):3-5.
1985: M M Konarska; P J Grabowski; R A Padgett; Phillip A Sharp
Characterization of the branch site in lariat RNAs produced by splicing of mRNA precursors.
Nature 1985;313(6003):552-7.
1985: K L Berkner; Phillip A Sharp
Effect of the tripartite leader on synthesis of a non-viral protein in an adenovirus 5 recombinant.
Nucleic acids research 1985;13(3):841-57.
1985: J P Capone; Phillip A Sharp; U L RajBhandary
Amber, ochre and opal suppressor tRNA genes derived from a human serine tRNA gene.
The EMBO journal 1985;4(1):213-21.
1985: Phillip A Sharp
Splicing of messenger RNA precursors.
Harvey lectures 1985;81():1-31.
1984: F A Laski; R Belagaje; R M Hudziak; Mario R Capecchi; G P Norton; P Palese; U L RajBhandary; Phillip A Sharp
Synthesis of an ochre suppressor tRNA gene and expression in mammalian cells.
The EMBO journal 1984;3(11):2445-52.
1984: M M Konarska; R A Padgett; Phillip A Sharp
Recognition of cap structure in splicing in vitro of mRNA precursors.
Cell 1984;38(3):731-6.
1984: R E Kingston; Randal J Kaufman; Phillip A Sharp
Regulation of transcription of the adenovirus EII promoter by EIa gene products: absence of sequence specificity.
Molecular and cellular biology 1984;4(10):1970-7.
1984: R A Padgett; M M Konarska; P J Grabowski; S F Hardy; Phillip A Sharp
Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors.
Science (New York, N.Y.) 1984;225(4665):898-903.
1984: P J Grabowski; R A Padgett; Phillip A Sharp
Messenger RNA splicing in vitro: an excised intervening sequence and a potential intermediate.
Cell 1984;37(2):415-27.
1984: H Handa; Phillip A Sharp
Requirement for distal upstream sequences for maximal transcription in vitro of early region IV of adenovirus.
Molecular and cellular biology 1984;4(4):791-8.
1984: S F Hardy; P J Grabowski; R A Padgett; Phillip A Sharp
Cofactor requirements of splicing of purified messenger RNA precursors.
Nature 1984;308(5957):375-7.
1984: C L Moore; Phillip A Sharp
Site-specific polyadenylation in a cell-free reaction.
Cell 1984;36(3):581-91.
1984: Andrew Fire; M Samuels; Phillip A Sharp
Interactions between RNA polymerase II, factors, and template leading to accurate transcription.
The Journal of biological chemistry 1984;259(4):2509-16.
1984: M Samuels; Andrew Fire; Phillip A Sharp
Dinucleotide priming of transcription mediated by RNA polymerase II.
The Journal of biological chemistry 1984;259(4):2517-25.
1984: K L Berkner; Phillip A Sharp
Expression of dihydrofolate reductase, and of the adjacent EIb region, in an Ad5-dihydrofolate reductase recombinant virus.
Nucleic acids research 1984;12(4):1925-41.
1983: R A Padgett; Steve Mount; J A Steitz; Phillip A Sharp
Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein.
Cell 1983;35(1):101-7.
1983: F A Laski; Andrew Fire; U L RajBhandary; Phillip A Sharp
Characterization of tRNA precursor splicing in mammalian extracts.
The Journal of biological chemistry 1983;258(19):11974-80.
1983: K L Berkner; Phillip A Sharp
Generation of adenovirus by transfection of plasmids.
Nucleic acids research 1983;11(17):6003-20.
1983: R A Padgett; S F Hardy; Phillip A Sharp
Splicing of adenovirus RNA in a cell-free transcription system.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(17):5230-4.
1983: Randal J Kaufman; Phillip A Sharp
Growth-dependent expression of dihydrofolate reductase mRNA from modular cDNA genes.
Molecular and cellular biology 1983;3(9):1598-608.
1983: C L Cepko; Phillip A Sharp
Analysis of Ad5 hexon and 100K ts mutants using conformation-specific monoclonal antibodies.
Virology 1983;129(1):137-54.
1983: W P Summers; W C Summers; F A Laski; U L RajBhandary; Phillip A Sharp
Functional suppression in mammalian cells of nonsense mutations in the herpes simplex virus thymidine kinase gene by suppressor tRNA genes.
Journal of virology 1983;47(2):376-9.
1983: H Handa; R E Kingston; Phillip A Sharp
Inhibition of adenovirus early region IV transcription in vitro by a purified viral DNA binding protein.
Nature 1983;302(5908):545-7.
1983: Randal J Kaufman; Phillip A Sharp; S A Latt
Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences.
Molecular and cellular biology 1983;3(4):699-711.
1983: C L Cepko; Phillip A Sharp
Aberrant distribution of human adenovirus type 2 late proteins in monkey kidney cells.
Journal of virology 1983;46(1):302-6.
1983: Phillip A Sharp
Conversion of RNA to DNA in mammals: Alu-like elements and pseudogenes.
Nature 1983;301(5900):471-2.
1983: C L Cepko; C A Whetstone; Phillip A Sharp
Adenovirus hexon monoclonal antibody that is group specific and potentially useful as a diagnostic reagent.
Journal of clinical microbiology 1983;17(2):360-4.
1983: U Hansen; Phillip A Sharp
Sequences controlling in vitro transcription of SV40 promoters.
The EMBO journal 1983;2(12):2293-303.
1983: J L Manley; Andrew Fire; M Samuels; Phillip A Sharp
In vitro transcription: whole-cell extract.
Methods in enzymology 1983;101():568-82.
1983: M Horowitz; C L Cepko; Phillip A Sharp
Expression of chimeric genes in the early region of SV40.
Journal of molecular and applied genetics 1983;2(2):147-59.
1982: M Samuels; Andrew Fire; Phillip A Sharp
Separation and characterization of factors mediating accurate transcription by RNA polymerase II.
The Journal of biological chemistry 1982;257(23):14419-27.
1982: C L Cepko; Phillip A Sharp
Assembly of adenovirus major capsid protein is mediated by a nonvirion protein.
Cell 1982;31(2 Pt 1):407-15.
1982: I Lemischka; Phillip A Sharp
The sequences of an expressed rat alpha-tubulin gene and a pseudogene with an inserted repetitive element.
Nature 1982;300(5890):330-5.
1982: R M Hudziak; F A Laski; U L RajBhandary; Phillip A Sharp; Mario R Capecchi
Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes.
Cell 1982;31(1):137-46.
1982: Randal J Kaufman; Phillip A Sharp
Construction of a modular dihydrofolate reductase cDNA gene: analysis of signals utilized for efficient expression.
Molecular and cellular biology 1982;2(11):1304-19.
1982: F A Laski; R Belagaje; U L RajBhandary; Phillip A Sharp
An amber suppressor tRNA gene derived by site-specific mutagenesis: cloning and function in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(19):5813-7.
1982: Randal J Kaufman; Phillip A Sharp
Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary dna gene.
Journal of molecular biology 1982;159(4):601-21.
1982: J L Manley; Phillip A Sharp; M L Gefter
Rna synthesis in isolated nuclei processing of adenovirus serotype 2 late messenger rna precursors.
Journal of molecular biology 1982;159(4):581-99.
1982: F A Laski; B Alzner-DeWeerd; U L RajBhandary; Phillip A Sharp
Expression of a X. laevis tRNATyr gene in mammalian cells.
Nucleic acids research 1982;10(15):4609-26.
1981: Andrew Fire; C C Baker; J L Manley; E B Ziff; Phillip A Sharp
In vitro transcription of adenovirus.
Journal of virology 1981;40(3):703-19.
1981: U Hansen; D G Tenen; David M Livingston; Phillip A Sharp
T antigen repression of SV40 early transcription from two promoters.
Cell 1981;27(3 Pt 2):603-13.
1981: N Crawford; Andrew Fire; M Samuels; Phillip A Sharp; David Baltimore
Inhibition of transcription factor activity by poliovirus.
Cell 1981;27(3 Pt 2):555-61.
1981: R P Ricciardi; R L Jones; C L Cepko; Phillip A Sharp; B E Roberts
Expression of early adenovirus genes requires a viral encoded acidic polypeptide.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(10):6121-5.
1981: C L Cepko; U Hansen; H Handa; Phillip A Sharp
Sequential transcription-translation of simian virus 40 by using mammalian cell extracts.
Molecular and cellular biology 1981;1(10):919-31.
1981: I R Lemischka; S Farmer; Vincent Racaniello; Phillip A Sharp
Nucleotide sequence and evolution of a mammalian alpha-tubulin messenger RNA.
Journal of molecular biology 1981;151(1):101-20.
1981: C L Cepko; Paul Changelian; Phillip A Sharp
Immunoprecipitation with two-dimensional pools as a hybridoma screening technique: production and characterization of monoclonal antibodies against adenovirus 2 proteins.
Virology 1981;110(2):385-401.
1981: Phillip A Sharp
Speculations on RNA splicing.
Cell 1981;23(3):643-6.
1981: H Handa; Randal J Kaufman; J Manley; M Gefter; Phillip A Sharp
Transcription of Simian virus 40 DNA in a HeLa whole cell extract.
The Journal of biological chemistry 1981;256(1):478-82.
1980: J L Manley; Andrew Fire; A Cano; Phillip A Sharp; M L Gefter
DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(7):3855-9.
1980: H Handa; Phillip A Sharp
Expression of early and late simian virus 40 transcripts in the absence of protein synthesis.
Journal of virology 1980;34(3):592-7.
1980: Phillip A Sharp; J Manley; Andrew Fire; M Gefter
Regulation of adenovirus mRNA synthesis.
Annals of the New York Academy of Sciences 1980;354():1-15.
1980: A J Berk; F Lee; T Harrison; J Williams; Phillip A Sharp
Phenotypes of adenovirus-5 host-range mutants for early-mRNA synthesis.
Cold Spring Harbor symposia on quantitative biology 1980;44 Pt 1,():429-36.
1980: D J Donoghue; mitchell goldfarb; Phillip A Sharp; Robert A. Weinberg
Organization of murine sarcoma virus genomes.
Cold Spring Harbor symposia on quantitative biology 1980;44 Pt 2,():721-6.
1980: Phillip A Sharp
Summary: molecular biology of viral oncogenes.
Cold Spring Harbor symposia on quantitative biology 1980;44 Pt 2,():1305-22.
1980: Phillip A Sharp; A J Berk; S M Berget
Transcription maps of adenovirus.
Methods in enzymology 1980;65(1):750-68.
1979: D J Donoghue; Phillip A Sharp; Robert A. Weinberg
Comparative study of different isolates of murine sarcoma virus.
Journal of virology 1979;32(3):1015-27.
1979: J L Manley; Phillip A Sharp; M L Gefter
RNA synthesis in isolated nuclei: identification and comparison of adenovirus 2 encoded transcripts synthesized in vitro and vivo.
Journal of molecular biology 1979;135(1):171-97.
1979: H M Kronenberg; B E McDevitt; J A Majzoub; Jeremy Nathans; Phillip A Sharp; J T Potts; A Rich
Cloning and nucleotide sequence of DNA coding for bovine preproparathyroid hormone.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(10):4981-5.
1979: A J Berk; F Lee; T Harrison; J Williams; Phillip A Sharp
Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs.
Cell 1979;17(4):935-44.
1979: D J Donoghue; Phillip A Sharp; Robert A. Weinberg
An MSV-specific subgenomic mRNA in MSV-transformed G8-124 cells.
Cell 1979;17(1):53-63.
1979: S M Berget; Phillip A Sharp
Structure of late adenovirus 2 heterogeneous nuclear RNA.
Journal of molecular biology 1979;129(4):547-65.
1979: R E Lockard; S M Berget; U L RajBhandary; Phillip A Sharp
Nucleotide sequence at the 5' terminus of adenovirus 2 late messenger RNA.
The Journal of biological chemistry 1979;254(3):587-90.
1979: J L Manley; Phillip A Sharp; M L Gefter
RNA synthesis in isolated nuclei: in vitro initiation of adenovirus 2 major late mRNA precursor.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(1):160-4.
1978: D J Donoghue; Phillip A Sharp
Construction of a hybrid bacteriophage-plasmid recombinant DNA vector.
Journal of bacteriology 1978;136(3):1192-6.
1978: D J Donoghue; E Rothenberg; N Hopkins; David Baltimore; Phillip A Sharp
Heteroduplex analysis of the nonhomology region between Moloney MuLV and the dual host range derivative HIX virus.
Cell 1978;14(4):959-70.
1978: A J Berk; Phillip A Sharp
Structure of the adenovirus 2 early mRNAs.
Cell 1978;14(3):695-711.
1978: D J Donoghue; Phillip A Sharp
Replication of colicin E1 plasmid DNA in vivo requires no plasmid-encoded proteins.
Journal of bacteriology 1978;133(3):1287-94.
1978: A J Berk; Phillip A Sharp
Spliced early mRNAs of simian virus 40.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(3):1274-8.
1978: S M Berget; A J Berk; T Harrison; Phillip A Sharp
Spliced segments at the 5' termini of adenovirus-2 late mRNA: a role for heterogeneous nuclear RNA in mammalian cells.
Cold Spring Harbor symposia on quantitative biology 1978;42 Pt 1():523-9.
1977: A J Berk; Phillip A Sharp
Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.
Cell 1977;12(3):721-32.
1977: A J Berk; Phillip A Sharp
Ultraviolet mapping of the adenovirus 2 early promoters.
Cell 1977;12(1):45-55.
1977: S M Berget; C Moore; Phillip A Sharp
Spliced segments at the 5' terminus of adenovirus 2 late mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(8):3171-5.
1977: S M Berget; Phillip A Sharp
A spliced sequence at the 5'-terminus of adenovirus late mRNA.
Brookhaven symposia in biology 1977;(29):332-44.
1977: D J Donoghue; Phillip A Sharp
An improved bacteriophage lambda vector: construction of model recombinants coding for kanamycin resistance.
Gene 1977;1(3-4):209-27.
1976: Phillip A Sharp; C Moore; J L Haverty
The infectivity of adenovirus 5 DNA-protein complex.
Virology 1976;75(2):442-56.
1976: S J Flint; S M Berget; Phillip A Sharp
Characterization of single-stranded viral DNA sequences present during replication of adenovirus types 2 and 5.
Cell 1976;9(4 Pt 1):559-71.
1976: S J Flint; Phillip A Sharp
Adenovirus transcription. V. Quantitation of viral RNA sequences in adenovirus 2-infected and transformed cells.
Journal of molecular biology 1976;106(3):749-74.
1976: S M Berget; S J Flint; J F Williams; Phillip A Sharp
Adenovirus transcription. IV. Synthesis of viral-specific RNA in human cells infected with temperature-sensitive mutants of adenovirus 5.
Journal of virology 1976;19(3):879-89.
1976: S J Flint; J Sambrook; J F Williams; Phillip A Sharp
Viral nucleic acid sequences in transformed cells. IV. A study of the sequences of adenovirus 5 DNA and RNA in four lines of adenovirus 5-transformed rodent cells using specific fragments of the viral genome.
Virology 1976;72(2):456-70.
1976: S J Flint; S M Berget; Phillip A Sharp
Adenovirus transcription. III. Mapping of viral RNA sequences in cells productively infected by adenovirus type 5.
Virology 1976;72(2):443-55.
1976: Phillip A Sharp; S J Flint
Adenovirus transcription.
Current topics in microbiology and immunology 1976;74():137-66.
1975: J Sambrook; J Williams; Phillip A Sharp; T Grodzicker
Physical mapping of temperature-sensitive mutations of adenoviruses.
Journal of molecular biology 1975;97(3):369-90.
1975: S J Flint; Y Wewerka-Lutz; A S Levine; J Sambrook; Phillip A Sharp
Adenovirus transcription. II. RNA sequences complementary to simian virus 40 and adenovirus 2DNA in AD2+ND1- and AD2+ND3-infected cells.
Journal of virology 1975;16(3):662-73.
1975: S J Flint; P H Gallimore; Phillip A Sharp
Comparison of viral RNA sequences in adenovirus 2-transformed and lytically infected cells.
Journal of molecular biology 1975;96(1):47-68.
1975: S J Flint; Phillip A Sharp
Mapping of viral-specific RNA in the cytoplasm and nucleus of adenovirus 2-infected human cells.
Brookhaven symposia in biology 1975;(26):333-58.
1975: V Mautner; J Williams; J Sambrook; Phillip A Sharp; T Grodzicker
The location of the genes coding for hexon and fiber proteins in adenovirus DNA.
Cell 1975;5(1):93-9.
1975: J Williams; T Grodzicker; Phillip A Sharp; J Sambrook
Adenovirus recombination: physical mapping of crossover events.
Cell 1975;4(2):113-9.
1975: Phillip A Sharp; P H Gallimore; S J Flint
Mapping of adenovirus 2 RNA sequences in lytically infected cells and transformed cell lines.
Cold Spring Harbor symposia on quantitative biology 1975;39 Pt 1():457-74.
1975: C Mulder; J R Arrand; H Delius; W Keller; U Pettersson; Richard J Roberts; Phillip A Sharp
Cleavage maps of DNA from adenovirus types 2 and 5 by restriction endonucleases EcoRI and HpaI.
Cold Spring Harbor symposia on quantitative biology 1975;39 Pt 1():397-400.
1975: J Sambrook; M Botchan; P Gallimore; B Ozanne; U Pettersson; J Williams; Phillip A Sharp
Viral DNA sequences in cells transformed by simian virus 40, adenovirus type 2 and adenovirus type 5.
Cold Spring Harbor symposia on quantitative biology 1975;39 Pt 1():615-32.
1975: T Grodzicker; J Williams; Phillip A Sharp; J Sambrook
Physical mapping of temperature-sensitive mutations of adenoviruses.
Cold Spring Harbor symposia on quantitative biology 1975;39 Pt 1():439-46.
1974: M Botchan; B Ozanne; William M. Sugden; Phillip A Sharp; J Sambrook
Viral DNA in transformed cells. III. The amounts of different regions of the SV40 genome present in a line of transformed mouse cells.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(10):4183-7.
1974: Phillip A Sharp; U Pettersson; J Sambrook
Viral DNA in transformed cells. I. A study of the sequences of adenovirus 2 DNA in a line of transformed rat cells using specific fragments of the viral genome.
Journal of molecular biology 1974;86(4):709-26.
1974: C Mulder; Phillip A Sharp; H Delius; U Pettersson
Specific fragmentation of DNA of adenovirus serotypes 3, 5, 7, and 12, and adeno-simian virus 40 hybrid virus Ad2+ND1 by restriction endonuclease R.EcoRI.
Journal of virology 1974;14(1):68-77.
1974: T Grodzicker; C Anderson; Phillip A Sharp; J Sambrook
Conditional lethal mutants of adenovirus 2-simian virus 40 hybrids. I. Host range mutants of Ad2+ND1.
Journal of virology 1974;13(6):1237-44.
1974: M Botchan; G McKenna; Phillip A Sharp
Cleavage of mouse DNA by a restriction enzyme as a clue to the arrangement of genes.
Cold Spring Harbor symposia on quantitative biology 1974;38():383-95.
1974: J Sambrook; Phillip A Sharp; B Ozanne; U Pettersson
Studies on the transcription of simian virus 40 and adenovirus type 2.
Basic life sciences 1974;3():167-79.
1973: J Sambrook; William M. Sugden; W Keller; Phillip A Sharp
Transcription of simian virus 40. 3. Mapping of "early" and "late" species of RNA.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(12):3711-5.
1973: Phillip A Sharp; William M. Sugden; J Sambrook
Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose--ethidium bromide electrophoresis.
Biochemistry 1973;12(16):3055-63.
1973: B Ozanne; Phillip A Sharp; J Sambrook
Transcription of simian virus 40. II. Hybridization of RNA extracted from different lines of transformed cells to the separated strands of simian virus 40 DNA.
Journal of virology 1973;12(1):90-8.
1973: Phillip A Sharp; S N Cohen; N Davidson
Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. II. Structure of drug resistance (R) factors and F factors.
Journal of molecular biology 1973;75(2):235-55.
1973: U Pettersson; C Mulder; H Deluis; Phillip A Sharp
Cleavage of adenovirus type 2 DNA into six unique fragments by endonuclease R-RI.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(1):200-4.
1972: Phillip A Sharp; M Hsu; N Davidson
Note on the structure of prophage lambda.
Journal of molecular biology 1972;71(2):499-501.
1972: Phillip A Sharp; M T Hsu; E Otsubo; N Davidson
Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. I. Structure of F-prime factors.
Journal of molecular biology 1972;71(2):471-97.
1972: J Sambrook; Phillip A Sharp; W Keller
Transcription of Simian virus 40. I. Separation of the strands of SV40 DNA and hybridization of the separated strands to RNA extracted from lytically infected and transformed cells.
Journal of molecular biology 1972;70(1):57-71.
1972: H T Tai; C A Smith; Phillip A Sharp; J Vinograd
Sequence heterogeneity in closed simian virus 40 deoxyribonucleic acid.
Journal of virology 1972;9(2):317-25.
1970: Phillip A Sharp; V A Bloomfield
Binding of proflavine and ethidium bromide to two forms of T2 bacteriophage with different sedimentation coefficients.
Biochemical and biophysical research communications 1970;39(3):407-13.