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Richard Sharpe

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TOP 3
Chris McKinnell; Rod T Mitchell; Keith Morris; Richard A Anderson; Chris J H Kelnar; W Hamish Wallace; Richard M Sharpe
Perinatal germ cell development and differentiation in the male marmoset (Callithrix jacchus): similarities with the human and differences from the rat.
Richard M Sharpe; Rod T Mitchell
The downside of 'inappropriate messaging': new insight into the development of testicular germ cell tumours in young men?
Afshan Dean; Chris McKinnell; William Mungall; Richard M Sharpe
Prostaglandins, masculinization and its disorders: effects of fetal exposure of the rat to the cyclooxygenase inhibitor- indomethacin.

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2013: Chris McKinnell; Rod T Mitchell; Keith Morris; Richard A Anderson; Chris J H Kelnar; W Hamish Wallace; Richard M Sharpe
Perinatal germ cell development and differentiation in the male marmoset (Callithrix jacchus): similarities with the human and differences from the rat.
Human reproduction (Oxford, England) 2013;28(4):886-96.
2013: Richard M Sharpe; Rod T Mitchell
The downside of 'inappropriate messaging': new insight into the development of testicular germ cell tumours in young men?
The Journal of pathology 2013;229(4):497-501.
2013: Afshan Dean; Chris McKinnell; William Mungall; Richard M Sharpe
Prostaglandins, masculinization and its disorders: effects of fetal exposure of the rat to the cyclooxygenase inhibitor- indomethacin.
PloS one 2013;8(5):e62556.
2013: Rod T Mitchell; Richard M Sharpe; Lee B Smith; Richard A Anderson; Christopher J H Kelnar; Sheila Macpherson; Chris McKinnell; W Hamish B Wallace; Sander van den Driesche
Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts.
PloS one 2013;8(4):e61726.
2012: S A Auharek; G F Avelar; N L M Lara; Richard M Sharpe; Luiz R França
Effects of inducible nitric oxide synthase (iNOS) deficiency in mice on Sertoli cell proliferation and perinatal testis development.
International journal of andrology 2012;35(5):741-51.
2012: A Dean; S Macpherson; L B Smith; Richard M Sharpe
The effect of dihydrotestosterone exposure during or prior to the masculinization programming window on reproductive development in male and female rats.
International journal of andrology 2012;35(3):330-9.
2012: Richard M Sharpe
Sperm counts and fertility in men: a rocky road ahead. Science & Society Series on Sex and Science.
EMBO reports 2012;13(5):398-403.
2012: R T Mitchell; Philippa Saunders; S van den Driesche; W H B Wallace; R A Anderson; A J Childs; C J H Kelnar; Chris McKinnell; Richard M Sharpe
Do phthalates affect steroidogenesis by the human fetal testis? Exposure of human fetal testis xenografts to di-n-butyl phthalate.
The Journal of clinical endocrinology and metabolism 2012;97(3):E341-8.
2012: Sander van den Driesche; Marion Walker; Lee B Smith; Richard A Anderson; Amanda J Drake; Sharon L Eddie; Chris McKinnell; Rod T Mitchell; Hayley M Scott; Jonathan R Seckl; Richard M Sharpe
Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents.
PloS one 2012;7(5):e37064.
2012: Sander van den Driesche; Amanda J Drake; Petros Kolovos; Sophie Platts; Richard M Sharpe
Inter-relationship between testicular dysgenesis and Leydig cell function in the masculinization programming window in the rat.
PloS one 2012;7(1):e30111.
2011: S A Auharek; G F Avelar; N L M Lara; Richard M Sharpe; Luiz R França
Sertoli cell numbers and spermatogenic efficiency are increased in inducible nitric oxide synthase mutant mice.
International journal of andrology 2011;34(6 Pt 2):e621-9.
2011: Sander van den Driesche; Marion Walker; M Fisken; D J MacLeod; H M Scott; Richard M Sharpe
Relative importance of prenatal and postnatal androgen action in determining growth of the penis and anogenital distance in the rat before, during and after puberty.
International journal of andrology 2011;34(6 Pt 2):e578-86.
2011: Richard M Sharpe
Pediatrics: endocrine disruption and human health effects--a call to action.
Nature reviews. Endocrinology 2011;7(11):633-4.
2011: M S Jobling; G R Hutchison; Sander van den Driesche; Richard M Sharpe
Effects of di(n-butyl) phthalate exposure on foetal rat germ-cell number and differentiation: identification of age-specific windows of vulnerability.
International journal of andrology 2011;34(5 Pt 2):e386-96.
2011: Michelle Welsh; David Brownstein; Alan McNeilly; Lindsey Moffat; Philippa Saunders; Richard M Sharpe; Lee B Smith
Smooth muscle cell-specific knockout of androgen receptor: a new model for prostatic disease.
Endocrinology 2011;152(9):3541-51.
2010: Rod T Mitchell; Philippa Saunders; Andrew J Childs; Claire Cassidy-Kojima; Richard A Anderson; W Hamish B Wallace; C J H Kelnar; Richard M Sharpe
Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation.
Human reproduction (Oxford, England) 2010;25(10):2405-14.
2010: Naomi D Elkin; Jacqui A Piner; Richard M Sharpe
Toxicant-induced leakage of germ cell-specific proteins from seminiferous tubules in the rat: relationship to blood-testis barrier integrity and prospects for biomonitoring.
Toxicological sciences : an official journal of the Society of Toxicology 2010;117(2):439-48.
2010: Michelle Welsh; Lindsey Moffat; Laura Jack; Alan McNeilly; David Brownstein; Philippa Saunders; Richard M Sharpe; Lee B Smith
Deletion of androgen receptor in the smooth muscle of the seminal vesicles impairs secretory function and alters its responsiveness to exogenous testosterone and estradiol.
Endocrinology 2010;151(7):3374-85.
2010: Richard M Sharpe; Amanda J Drake
Bisphenol a and metabolic syndrome.
Endocrinology 2010;151(6):2404-7.
2010: Sarah A Auharek; Luiz R de Franca; Chris McKinnell; Matthew S Jobling; Hayley M Scott; Richard M Sharpe
Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat.
Endocrinology 2010;151(6):2868-75.
2010: Richard M Sharpe
Environmental/lifestyle effects on spermatogenesis.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2010;365(1546):1697-712.
2010: D J Macleod; Richard M Sharpe; M Welsh; M Fisken; H M Scott; G R Hutchison; A J Drake; S van den Driesche
Androgen action in the masculinization programming window and development of male reproductive organs.
International journal of andrology 2010;33(2):279-87.
2010: Richard M Sharpe
Is it time to end concerns over the estrogenic effects of bisphenol A?
Toxicological sciences : an official journal of the Society of Toxicology 2010;114(1):1-4.
2010: Michelle Welsh; David J MacLeod; Marion Walker; Lee B Smith; Richard M Sharpe
Critical androgen-sensitive periods of rat penis and clitoris development.
International journal of andrology 2010;33(1):e144-52.
2010: Ariane Willems; Sergio R Batlouni; Arantza Esnal; Johannes V Swinnen; Philippa Saunders; Richard M Sharpe; Luiz R França; Karel De Gendt; Guido Verhoeven
Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development.
PloS one 2010;5(11):e14168.
2010: Michelle Welsh; Richard M Sharpe; Lindsey Moffat; Nina Atanassova; Philippa Saunders; Sigrid Kilter; Anders Bergh; Lee B Smith
Androgen action via testicular arteriole smooth muscle cells is important for Leydig cell function, vasomotion and testicular fluid dynamics.
PloS one 2010;5(10):e13632.
2009: Hayley M Scott; J Ian Mason; Richard M Sharpe
Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds.
Endocrine reviews 2009;30(7):883-925.
2009: Michelle Welsh; Philippa Saunders; Nina Atanassova; Richard M Sharpe; Lee B Smith
Androgen action via testicular peritubular myoid cells is essential for male fertility.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(12):4218-30.
2009: Karel De Gendt; Chris McKinnell; Ariane Willems; Philippa Saunders; Richard M Sharpe; Nina Atanassova; Johannes V Swinnen; Guido Verhoeven
Organotypic cultures of prepubertal mouse testes: a method to study androgen action in sertoli cells while preserving their natural environment.
Biology of reproduction 2009;81(6):1083-92.
2009: Amanda J Drake; Sander van den Driesche; Hayley M Scott; Gary R Hutchison; Jonathan R Seckl; Richard M Sharpe
Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development.
Endocrinology 2009;150(11):5055-64.
2009: Chris McKinnell; Rod T Mitchell; Marion Walker; Keith Morris; C J H Kelnar; W Hamish B Wallace; Richard M Sharpe
Effect of fetal or neonatal exposure to monobutyl phthalate (MBP) on testicular development and function in the marmoset.
Human reproduction (Oxford, England) 2009;24(9):2244-54.
2009: Michelle Welsh; Richard M Sharpe; Marion Walker; Lee B Smith; Philippa Saunders
New insights into the role of androgens in wolffian duct stabilization in male and female rodents.
Endocrinology 2009;150(5):2472-80.
2009: Bronwen Martin; Stuart Maudsley; Judy R McNeilly; Linda Nicol; Janet Crawford; Michael Millar; Richard M Sharpe; Alan S McNeilly
Neonatal estrogenic effects upon the male rat pituitary: early gonadotrophin attenuation precedes long-term recovery.
Neuromolecular medicine 2009;11(2):76-86.
2009: R T Mitchell; Philippa Saunders; Richard M Sharpe; C J H Kelnar; W H B Wallace
Male fertility and strategies for fertility preservation following childhood cancer treatment.
Endocrine development 2009;15():101-34.
2008: R T Mitchell; G Cowan; Keith D Morris; Richard A Anderson; Hamish M Fraser; K J Mckenzie; W Hamish B Wallace; C J H Kelnar; Philippa Saunders; Richard M Sharpe
Germ cell differentiation in the marmoset (Callithrix jacchus) during fetal and neonatal life closely parallels that in the human.
Human reproduction (Oxford, England) 2008;23(12):2755-65.
2008: Hayley M Scott; Gary R Hutchison; Matthew S Jobling; Chris McKinnell; Amanda J Drake; Richard M Sharpe
Relationship between androgen action in the "male programming window," fetal sertoli cell number, and adult testis size in the rat.
Endocrinology 2008;149(10):5280-7.
2008: Richard M Sharpe
"Additional" effects of phthalate mixtures on fetal testosterone production.
Toxicological sciences : an official journal of the Society of Toxicology 2008;105(1):1-4.
2008: Michelle Welsh; Philippa Saunders; Mark Fisken; Hayley M Scott; Gary R Hutchison; Lee B Smith; Richard M Sharpe
Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism.
The Journal of clinical investigation 2008;118(4):1479-90.
2008: Gary R Hutchison; Richard M Sharpe; I Kim Mahood; Matt Jobling; Marion Walker; Chris McKinnell; J Ian Mason; Hayley M Scott
The origins and time of appearance of focal testicular dysgenesis in an animal model of testicular dysgenesis syndrome: evidence for delayed testis development?
International journal of andrology 2008;31(2):103-11.
2008: Richard M Sharpe; Niels E Skakkebaek
Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects.
Fertility and sterility 2008;89(2 Suppl):e33-8.
2008: Mari S Golub; Gwen Collman; Paul M D Foster; Carole A Kimmel; Ewa Rajpert-De Meyts; Edward O Reiter; Richard M Sharpe; Niels E Skakkebaek; Jorma Toppari
Public health implications of altered puberty timing.
Pediatrics 2008;121 Suppl 3():S218-30.
2008: Gary R Hutchison; Hayley M Scott; Marion Walker; Chris McKinnell; Diana Ferrara; I Kim Mahood; Richard M Sharpe
Sertoli cell development and function in an animal model of testicular dysgenesis syndrome.
Biology of reproduction 2008;78(2):352-60.
2007: I Kim Mahood; Hayley M Scott; Richard Brown; Nina Hallmark; Marion Walker; Richard M Sharpe
In utero exposure to di(n-butyl) phthalate and testicular dysgenesis: comparison of fetal and adult end points and their dose sensitivity.
Environmental health perspectives 2007;115 Suppl 1():55-61.
2007: Michelle Welsh; Philippa Saunders; Richard M Sharpe
The critical time window for androgen-dependent development of the Wolffian duct in the rat.
Endocrinology 2007;148(7):3185-95.
2007: Simon Plummer; Richard M Sharpe; Nina Hallmark; I Kim Mahood; Cliff Elcombe
Time-dependent and compartment-specific effects of in utero exposure to Di(n-butyl) phthalate on gene/protein expression in the fetal rat testis as revealed by transcription profiling and laser capture microdissection.
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(2):520-32.
2007: Hayley M Scott; Gary R Hutchison; I Kim Mahood; Nina Hallmark; Michelle Welsh; Karel De Gendt; Guido Verhoeven; Peter O'Shaughnessy; Richard M Sharpe
Role of androgens in fetal testis development and dysgenesis.
Endocrinology 2007;148(5):2027-36.
2007: Nina Hallmark; Marion Walker; Chris McKinnell; I Kim Mahood; Hayley Scott; Rosemary Bayne; Shiona Coutts; Richard A Anderson; Irene Greig; Keith Morris; Richard M Sharpe
Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human.
Environmental health perspectives 2007;115(3):390-6.
2006: Diana Ferrara; Nina Hallmark; Hayley Scott; Richard Brown; Chris McKinnell; I Kim Mahood; Richard M Sharpe
Acute and long-term effects of in utero exposure of rats to di(n-butyl) phthalate on testicular germ cell development and proliferation.
Endocrinology 2006;147(11):5352-62.
2006: Michelle Welsh; Philippa Saunders; Nicholas I Marchetti; Richard M Sharpe
Androgen-dependent mechanisms of Wolffian duct development and their perturbation by flutamide.
Endocrinology 2006;147(10):4820-30.
2006: Karen A L Tan; Marion Walker; Keith Morris; Irene Greig; J Ian Mason; Richard M Sharpe
Infant feeding with soy formula milk: effects on puberty progression, reproductive function and testicular cell numbers in marmoset monkeys in adulthood.
Human reproduction (Oxford, England) 2006;21(4):896-904.
2006: Richard M Sharpe
Pathways of endocrine disruption during male sexual differentiation and masculinization.
Best practice & research. Clinical endocrinology & metabolism 2006;20(1):91-110.
2006: I Kim Mahood; Chris McKinnell; Marion Walker; Nina Hallmark; Hayley Scott; Jane S Fisher; Ana Rivas; Stefan Hartung; Richard Ivell; J Ian Mason; Richard M Sharpe
Cellular origins of testicular dysgenesis in rats exposed in utero to di(n-butyl) phthalate.
International journal of andrology 2006;29(1):148-54; discussion 181-5.
2006: Evi Denolet; Karel De Gendt; Joke Allemeersch; Kristof Engelen; Kathleen Marchal; Paul van Hummelen; Karen A L Tan; Richard M Sharpe; Philippa Saunders; Johannes V Swinnen; Guido Verhoeven
The effect of a sertoli cell-selective knockout of the androgen receptor on testicular gene expression in prepubertal mice.
Molecular endocrinology (Baltimore, Md.) 2006;20(2):321-34.
2005: Catriona Paul; Stewart M Rhind; Carol E Kyle; Hayley Scott; Chris McKinnell; Richard M Sharpe
Cellular and hormonal disruption of fetal testis development in sheep reared on pasture treated with sewage sludge.
Environmental health perspectives 2005;113(11):1580-7.
2005: Chris McKinnell; Richard M Sharpe; Kim Mahood; Nina Hallmark; Hayley Scott; Richard Ivell; Christophe Staub; Bernard Jégou; Friedrich Haag; Friedrich Koch-Nolte; Stefan Hartung
Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate.
Endocrinology 2005;146(10):4536-44.
2005: Karel De Gendt; Nina Atanassova; Karen A L Tan; Luiz Renato de França; Gleydes G Parreira; Chris McKinnell; Richard M Sharpe; Philippa Saunders; J Ian Mason; Stefan Hartung; Richard Ivell; Evi Denolet; Guido Verhoeven
Development and function of the adult generation of Leydig cells in mice with Sertoli cell-selective or total ablation of the androgen receptor.
Endocrinology 2005;146(9):4117-26.
2005: Karen A L Tan; Karel De Gendt; Nina Atanassova; Marion Walker; Richard M Sharpe; Philippa Saunders; Evi Denolet; Guido Verhoeven
The role of androgens in sertoli cell proliferation and functional maturation: studies in mice with total or Sertoli cell-selective ablation of the androgen receptor.
Endocrinology 2005;146(6):2674-83.
2005: Nina Atanassova; Chris McKinnell; Jane Fisher; Richard M Sharpe
Neonatal treatment of rats with diethylstilboestrol (DES) induces stromal-epithelial abnormalities of the vas deferens and cauda epididymis in adulthood following delayed basal cell development.
Reproduction (Cambridge, England) 2005;129(5):589-601.
2005: Karen A L Tan; Katie J Turner; Philippa Saunders; Guido Verhoeven; Karel De Gendt; Nina Atanassova; Richard M Sharpe
Androgen regulation of stage-dependent cyclin D2 expression in Sertoli cells suggests a role in modulating androgen action on spermatogenesis.
Biology of reproduction 2005;72(5):1151-60.
2005: I Kim Mahood; Nina Hallmark; Chris McKinnell; Marion Walker; Jane S Fisher; Richard M Sharpe
Abnormal Leydig Cell aggregation in the fetal testis of rats exposed to di (n-butyl) phthalate and its possible role in testicular dysgenesis.
Endocrinology 2005;146(2):613-23.
2005: Nina Atanassova; Marion Walker; Chris McKinnell; Jane S Fisher; Richard M Sharpe
Evidence that androgens and oestrogens, as well as follicle-stimulating hormone, can alter Sertoli cell number in the neonatal rat.
The Journal of endocrinology 2005;184(1):107-17.
2004: Richard M Sharpe
Environmental oestrogens: foe or friend?
Journal of neuroendocrinology 2004;16(10):867-8.
2004: Richard M Sharpe; D Stewart Irvine
How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health?
BMJ (Clinical research ed.) 2004;328(7437):447-51.
2004: Karel De Gendt; Johannes V Swinnen; Philippa Saunders; Luc Schoonjans; Mieke Dewerchin; Ann Devos; Karen Tan; Nina Atanassova; Frank Claessens; Charlotte Lécureuil; Walter Heyns; Peter Carmeliet; Florian Guillou; Richard M Sharpe; Guido Verhoeven
A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(5):1327-32.
2003: Richard M Sharpe; Hamish M Fraser; M F H Brougham; Chris McKinnell; Keith D Morris; C J H Kelnar; W Hamish B Wallace; Marion Walker
Role of the neonatal period of pituitary-testicular activity in germ cell proliferation and differentiation in the primate testis.
Human reproduction (Oxford, England) 2003;18(10):2110-7.
2003: Jane S Fisher; Sheila Macpherson; N Marchetti; Richard M Sharpe
Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate.
Human reproduction (Oxford, England) 2003;18(7):1383-94.
2003: Ana Rivas; Chris McKinnell; Jane S Fisher; Nina Atanassova; Karin Williams; Richard M Sharpe
Neonatal coadministration of testosterone with diethylstilbestrol prevents diethylstilbestrol induction of most reproductive tract abnormalities in male rats.
Journal of andrology 2003;24(4):557-67.
2003: Richard M Sharpe; Chris McKinnell; Catrina Kivlin; Jane S Fisher
Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood.
Reproduction (Cambridge, England) 2003;125(6):769-84.
2003: Richard M Sharpe; Ana Rivas; Marion Walker; Chris McKinnell; Jane S Fisher
Effect of neonatal treatment of rats with potent or weak (environmental) oestrogens, or with a GnRH antagonist, on Leydig cell development and function through puberty into adulthood.
International journal of andrology 2003;26(1):26-36.
2003: Richard M Sharpe
The 'oestrogen hypothesis'- where do we stand now?
International journal of andrology 2003;26(1):2-15.
2002: Ana Rivas; Jane S Fisher; Chris McKinnell; Nina Atanassova; Richard M Sharpe
Induction of reproductive tract developmental abnormalities in the male rat by lowering androgen production or action in combination with a low dose of diethylstilbestrol: evidence for importance of the androgen-estrogen balance.
Endocrinology 2002;143(12):4797-808.
2002: Richard M Sharpe; Stephen Franks
Environment, lifestyle and infertility--an inter-generational issue.
Nature cell biology 2002;4 Suppl():s33-40.
2002: Angela B Thomson; Richard A Anderson; D Stewart Irvine; C J H Kelnar; Richard M Sharpe; W Hamish B Wallace
Investigation of suppression of the hypothalamic-pituitary-gonadal axis to restore spermatogenesis in azoospermic men treated for childhood cancer.
Human reproduction (Oxford, England) 2002;17(7):1715-23.
2002: Richard M Sharpe; Bronwen Martin; Keith Morris; Irene Greig; Chris McKinnell; Alan S McNeilly; Marion Walker
Infant feeding with soy formula milk: effects on the testis and on blood testosterone levels in marmoset monkeys during the period of neonatal testicular activity.
Human reproduction (Oxford, England) 2002;17(7):1692-703.
2002: Philippa Saunders; Michael R Millar; Sheila Macpherson; D Stewart Irvine; nigel P groome; Lee R Evans; Richard M Sharpe; Graeme A Scobie
ERbeta1 and the ERbeta2 splice variant (ERbetacx/beta2) are expressed in distinct cell populations in the adult human testis.
The Journal of clinical endocrinology and metabolism 2002;87(6):2706-15.
2002: C J H Kelnar; Chris McKinnell; Marion Walker; Keith D Morris; W Hamish B Wallace; Philippa Saunders; Hamish M Fraser; Richard M Sharpe
Testicular changes during infantile 'quiescence' in the marmoset and their gonadotrophin dependence: a model for investigating susceptibility of the prepubertal human testis to cancer therapy?
Human reproduction (Oxford, England) 2002;17(5):1367-78.
2002: Katie J Turner; Sheila Macpherson; Michael R Millar; A S McNeilly; K Williams; M Cranfield; nigel P groome; Richard M Sharpe; H M Fraser; Philippa Saunders
Development and validation of a new monoclonal antibody to mammalian aromatase.
The Journal of endocrinology 2002;172(1):21-30.
2001: Karin Williams; Jane S Fisher; Katie J Turner; Chris McKinnell; Philippa Saunders; Richard M Sharpe
Relationship between expression of sex steroid receptors and structure of the seminal vesicles after neonatal treatment of rats with potent or weak estrogens.
Environmental health perspectives 2001;109(12):1227-35.
2001: Chris McKinnell; Philippa Saunders; Hamish M Fraser; C J H Kelnar; C Kivlin; Keith D Morris; Richard M Sharpe
Comparison of androgen receptor and oestrogen receptor beta immunoexpression in the testes of the common marmoset (Callithrix jacchus) from birth to adulthood: low androgen receptor immunoexpression in Sertoli cells during the neonatal increase in testosterone concentrations.
Reproduction (Cambridge, England) 2001;122(3):419-29.
2001: Katie J Turner; M Morley; Sheila Macpherson; Michael R Millar; J A Wilson; Richard M Sharpe; Philippa Saunders
Modulation of gene expression by androgen and oestrogens in the testis and prostate of the adult rat following androgen withdrawal.
Molecular and cellular endocrinology 2001;178(1-2):73-87.
2001: Richard M Sharpe
Hormones and testis development and the possible adverse effects of environmental chemicals.
Toxicology letters 2001;120(1-3):221-32.
2001: Chris McKinnell; Nina Atanassova; Karin Williams; Jane S Fisher; Marion Walker; Katie J Turner; Thomas L Saunders; Richard M Sharpe
Suppression of androgen action and the induction of gross abnormalities of the reproductive tract in male rats treated neonatally with diethylstilbestrol.
Journal of andrology 2001;22(2):323-38.
2001: Philippa Saunders; Richard M Sharpe; K Williams; Sheila Macpherson; H Urquart; D Stewart Irvine; Michael R Millar
Differential expression of oestrogen receptor alpha and beta proteins in the testes and male reproductive system of human and non-human primates.
Molecular human reproduction 2001;7(3):227-36.
2001: Nina Atanassova; Chris McKinnell; K Williams; Katie J Turner; Jane S Fisher; Philippa Saunders; Michael R Millar; Richard M Sharpe
Age-, cell- and region-specific immunoexpression of estrogen receptor alpha (but not estrogen receptor beta) during postnatal development of the epididymis and vas deferens of the rat and disruption of this pattern by neonatal treatment with diethylstilbestrol.
Endocrinology 2001;142(2):874-86.
2000: Nina Atanassova; Chris McKinnell; Katie J Turner; Marion Walker; Jane S Fisher; M Morley; Michael R Millar; nigel P groome; Richard M Sharpe
Comparative effects of neonatal exposure of male rats to potent and weak (environmental) estrogens on spermatogenesis at puberty and the relationship to adult testis size and fertility: evidence for stimulatory effects of low estrogen levels.
Endocrinology 2000;141(10):3898-907.
2000: Michael R Millar; Richard M Sharpe; Gerhard Weinbauer; Hamish M Fraser; Philippa Saunders
Marmoset spermatogenesis: organizational similarities to the human.
International journal of andrology 2000;23(5):266-77.
2000: Richard M Sharpe
Environment, lifestyle and male infertility.
Baillière's best practice & research. Clinical endocrinology & metabolism 2000;14(3):489-503.
2000: Karin Williams; Philippa Saunders; Nina Atanassova; Jane S Fisher; Katie J Turner; Michael R Millar; Chris McKinnell; Richard M Sharpe
Induction of progesterone receptor immunoexpression in stromal tissue throughout the male reproductive tract after neonatal oestrogen treatment of rats.
Molecular and cellular endocrinology 2000;164(1-2):117-31.
2000: Richard A Anderson; Richard M Sharpe
Regulation of inhibin production in the human male and its clinical applications.
International journal of andrology 2000;23(3):136-44.
2000: Richard M Sharpe; M Walker; Michael R Millar; Nina Atanassova; K Morris; Chris McKinnell; Philippa Saunders; Hamish M Fraser
Effect of neonatal gonadotropin-releasing hormone antagonist administration on sertoli cell number and testicular development in the marmoset: comparison with the rat.
Biology of reproduction 2000;62(6):1685-93.
2000: Katie J Turner; M Morley; Nina Atanassova; I D Swanston; Richard M Sharpe
Effect of chronic administration of an aromatase inhibitor to adult male rats on pituitary and testicular function and fertility.
The Journal of endocrinology 2000;164(2):225-38.
2000: Richard M Sharpe
Lifestyle and environmental contribution to male infertility.
British medical bulletin 2000;56(3):630-42.
1999: Nina Atanassova; Chris McKinnell; Marion Walker; Katie J Turner; Jane S Fisher; M Morley; Michael R Millar; nigel P groome; Richard M Sharpe
Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number, and the efficiency of spermatogenesis in adulthood.
Endocrinology 1999;140(11):5364-73.
1999: Jane S Fisher; Katie J Turner; D Brown; Richard M Sharpe
Effect of neonatal exposure to estrogenic compounds on development of the excurrent ducts of the rat testis through puberty to adulthood.
Environmental health perspectives 1999;107(5):397-405.
1999: Richard M Sharpe; Katie J Turner; Chris McKinnell; nigel P groome; Nina Atanassova; Michael R Millar; David Lee Buchanan; Paul S Cooke
Inhibin B levels in plasma of the male rat from birth to adulthood: effect of experimental manipulation of Sertoli cell number.
Journal of andrology 1999;20(1):94-101.
1998: Richard M Sharpe
The roles of oestrogen in the male.
Trends in endocrinology and metabolism: TEM 1998;9(9):371-7.
1998: Richard M Sharpe; Nina Atanassova; Chris McKinnell; P Parte; Katie J Turner; Jane S Fisher; J B Kerr; nigel P groome; Sheila Macpherson; Michael R Millar; Philippa Saunders
Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethylstilbestrol: a possible role for estrogens in Sertoli cell development.
Biology of reproduction 1998;59(5):1084-94.
1998: Jane S Fisher; Katie J Turner; Hamish M Fraser; Philippa Saunders; D Brown; Richard M Sharpe
Immunoexpression of aquaporin-1 in the efferent ducts of the rat and marmoset monkey during development, its modulation by estrogens, and its possible role in fluid resorption.
Endocrinology 1998;139(9):3935-45.
1998: Philippa Saunders; J S Fisher; Richard M Sharpe; Michael R Millar
Expression of oestrogen receptor beta (ER beta) occurs in multiple cell types, including some germ cells, in the rat testis.
The Journal of endocrinology 1998;156(3):R13-7.
1997: Katie J Turner; Richard M Sharpe; J Gaughan; Michael R Millar; Paul M D Foster; Philippa Saunders
Expression cloning of a rat testicular transcript abundant in germ cells, which contains two leucine zipper motifs.
Biology of reproduction 1997;57(5):1223-32.
1997: S M Maguire; Michael R Millar; Richard M Sharpe; J Gaughan; Philippa Saunders
Investigation of the potential role of the germ cell complement in control of the expression of transferrin mRNA in the prepubertal and adult rat testis.
Journal of molecular endocrinology 1997;19(1):67-77.
1997: Chris McKinnell; Richard M Sharpe
Regulation of the secretion and synthesis of rat Sertoli cell SGP-1, SGP-2 and CP-2 by elongate spermatids.
International journal of andrology 1997;20(3):171-9.
1997: Jane S Fisher; Michael R Millar; G Majdic; Philippa Saunders; Hamish M Fraser; Richard M Sharpe
Immunolocalisation of oestrogen receptor-alpha within the testis and excurrent ducts of the rat and marmoset monkey from perinatal life to adulthood.
The Journal of endocrinology 1997;153(3):485-95.
1997: Katie J Turner; Richard M Sharpe
Environmental oestrogens--present understanding.
Reviews of reproduction 1997;2(2):69-73.
1997: G Majdic; Alan S McNeilly; Richard M Sharpe; Lee R Evans; nigel P groome; Philippa Saunders
Testicular expression of inhibin and activin subunits and follistatin in the rat and human fetus and neonate and during postnatal development in the rat.
Endocrinology 1997;138(5):2136-47.
1997: G Majdic; Richard M Sharpe; Philippa Saunders
Maternal oestrogen/xenoestrogen exposure alters expression of steroidogenic factor-1 (SF-1/Ad4BP) in the fetal rat testis.
Molecular and cellular endocrinology 1997;127(1):91-8.
1997: Philippa Saunders; G Majdic; P Parte; Michael R Millar; Jane S Fisher; Katie J Turner; Richard M Sharpe
Fetal and perinatal influence of xenoestrogens on testis gene expression.
Advances in experimental medicine and biology 1997;424():99-110.
1996: Katie J Turner; Chris McKinnell; T T McLaren; S J Qureshi; Philippa Saunders; P M Foster; Richard M Sharpe
Detection of germ cell-derived proteins in testicular interstitial fluid: potential for monitoring spermatogenesis in vivo.
Journal of andrology 1996;17(2):127-36.
1996: G Majdic; Richard M Sharpe; P J O'Shaughnessy; Philippa Saunders
Expression of cytochrome P450 17alpha-hydroxylase/C17-20 lyase in the fetal rat testis is reduced by maternal exposure to exogenous estrogens.
Endocrinology 1996;137(3):1063-70.
1995: Michael R Millar; Richard M Sharpe; S M Maguire; J Gaughan; Philippa Saunders
Colocalization of mRNA and protein using in situ hybridization and immunohistochemistry in testicular tissue.
Microscopy research and technique 1995;32(6):498-503.
1995: Richard M Sharpe; Jane S Fisher; M M Millar; S Jobling; John P Sumpter
Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production.
Environmental health perspectives 1995;103(12):1136-43.
1995: Chris McKinnell; Richard M Sharpe
Testosterone and spermatogenesis: evidence that androgens regulate cellular secretory mechanisms in stage VI-VIII seminiferous tubules from adult rats.
Journal of andrology 1995;16(6):499-509.
1995: Richard M Sharpe; S M Maguire; Philippa Saunders; Michael R Millar; L D Russell; D Ganten; S Bachmann; L Mullins; J J Mullins
Infertility in a transgenic rat due to impairment of cytoplasmic elimination and sperm release from the Sertoli cells.
Biology of reproduction 1995;53(2):214-26.
1995: Richard M Sharpe; S M Maguire; Philippa Saunders; Michael R Millar; L D Russell; D Ganten; S Bachmann; L Mullins; J J Mullins
Infertility in a transgenic rat due to impairment of cytoplasmic elimination and sperm release from the Sertoli cells.
Biology of reproduction 1995;53(1):214-26.
1995: Richard M Sharpe
On the importance of being earnest. Decline in semen quality among fertile men in Paris during the past 20 years.
Human & experimental toxicology 1995;14(5):463-4.
1995: Chris McKinnell; E T Brackenbury; S J Qureshi; T B Hargreave; Richard M Sharpe
Comparative analysis of proteins secreted in vitro by isolated seminiferous tubules from man and the rat.
International journal of andrology 1995;18(2):103-11.
1995: Philippa Saunders; Chris McKinnell; Michael R Millar; J Gaughan; Katie J Turner; Bernard Jégou; V Syed; Richard M Sharpe
Phosphatidylethanolamine binding protein is an abundant secretory product of haploid testicular germ cells in the rat.
Molecular and cellular endocrinology 1995;107(2):221-30.
1995: A P West; Chris McKinnell; Richard M Sharpe; Philippa Saunders
Pituitary adenylate cyclase activating polypeptide can regulate testicular germ cell protein synthesis in vitro.
The Journal of endocrinology 1995;144(2):215-23.
1994: T T McLaren; P M Foster; Richard M Sharpe
Identification of stage-specific changes in protein secretion by isolated seminiferous tubules from rats following exposure to short-term local testicular heating.
Journal of reproduction and fertility 1994;102(2):293-300.
1994: W J Bremner; Michael R Millar; Richard M Sharpe; Philippa Saunders
Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens.
Endocrinology 1994;135(3):1227-34.
1994: Michael R Millar; Richard M Sharpe; S M Maguire; J Gaughan; A P West; Philippa Saunders
Localization of mRNAs by in-situ hybridization to the residual body at stages IX-X of the cycle of the rat seminiferous epithelium: fact or artefact?
International journal of andrology 1994;17(3):149-60.
1994: Richard M Sharpe; J B Kerr; Chris McKinnell; M Millar
Temporal relationship between androgen-dependent changes in the volume of seminiferous tubule fluid, lumen size and seminiferous tubule protein secretion in rats.
Journal of reproduction and fertility 1994;101(1):193-8.
1994: A P West; Richard M Sharpe; Philippa Saunders
Differential regulation of cyclic adenosine 3',5'-monophosphate (cAMP) response element-binding protein and cAMP response element modulator messenger ribonucleic acid transcripts by follicle-stimulating hormone and androgen in the adult rat testis.
Biology of reproduction 1994;50(4):869-81.
1993: T T McLaren; P M Foster; Richard M Sharpe
Effect of age on seminiferous tubule protein secretion and the adverse effects of testicular toxicants in the rat.
International journal of andrology 1993;16(6):370-9.
1993: S J Qureshi; Richard M Sharpe
Evaluation of possible determinants and consequences of Leydig cell heterogeneity in man.
International journal of andrology 1993;16(5):293-305.
1993: T T McLaren; P M Foster; Richard M Sharpe
Identification of stage-specific changes in protein secretion by isolated seminiferous tubules from the rat following exposure to either m-dinitrobenzene or nitrobenzene.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1993;21(3):384-92.
1993: J B Kerr; G N Savage; M Millar; Richard M Sharpe
Response of the seminiferous epithelium of the rat testis to withdrawal of androgen: evidence for direct effect upon intercellular spaces associated with Sertoli cell junctional complexes.
Cell and tissue research 1993;274(1):153-61.
1993: Michael R Millar; Richard M Sharpe; S M Maguire; Philippa Saunders
Cellular localisation of messenger RNAs in rat testis: application of digoxigenin-labelled ribonucleotide probes to embedded tissue.
Cell and tissue research 1993;273(2):269-77.
1993: S Maddocks; T B Hargreave; K Reddie; Hamish M Fraser; J B Kerr; Richard M Sharpe
Intratesticular hormone levels and the route of secretion of hormones from the testis of the rat, guinea pig, monkey and human.
International journal of andrology 1993;16(4):272-8.
1993: S M Maguire; Michael R Millar; Richard M Sharpe; Philippa Saunders
Stage-dependent expression of mRNA for cyclic protein 2 during spermatogenesis is modulated by elongate spermatids.
Molecular and cellular endocrinology 1993;94(1):79-88.
1993: Richard M Sharpe; N E Skakkebaek
Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?
Lancet 1993;341(8857):1392-5.
1993: J B Kerr; M Millar; S Maddocks; Richard M Sharpe
Stage-dependent changes in spermatogenesis and Sertoli cells in relation to the onset of spermatogenic failure following withdrawal of testosterone.
The Anatomical record 1993;235(4):547-59.
1993: Richard M Sharpe
Declining sperm counts in men--is there an endocrine cause?
The Journal of endocrinology 1993;136(3):357-60.
1993: Richard M Sharpe; M Millar; Chris McKinnell
Relative roles of testosterone and the germ cell complement in determining stage-dependent changes in protein secretion by isolated rat seminiferous tubules.
International journal of andrology 1993;16(1):71-81.
1993: Philippa Saunders; Michael R Millar; A P West; Richard M Sharpe
Mitochondrial cytochrome C oxidase II messenger ribonucleic acid is expressed in pachytene spermatocytes at high levels and in a stage-dependent manner during spermatogenesis in the rat.
Biology of reproduction 1993;48(1):57-67.
1992: Philippa Saunders; Michael R Millar; S M Maguire; Richard M Sharpe
Stage-specific expression of rat transition protein 2 mRNA and possible localization to the chromatoid body of step 7 spermatids by in situ hybridization using a nonradioactive riboprobe.
Molecular reproduction and development 1992;33(4):385-91.
1992: J B Kerr; S Maddocks; Richard M Sharpe
Testosterone and FSH have independent, synergistic and stage-dependent effects upon spermatogenesis in the rat testis.
Cell and tissue research 1992;268(1):179-89.
1992: S Maddocks; J B Kerr; G Allenby; Richard M Sharpe
Evaluation of the role of germ cells in regulating the route of secretion of immunoactive inhibin from the rat testis.
The Journal of endocrinology 1992;132(3):439-48.
1992: Richard M Sharpe; S Maddocks; M Millar; J B Kerr; Philippa Saunders; Chris McKinnell
Testosterone and spermatogenesis. Identification of stage-specific, androgen-regulated proteins secreted by adult rat seminiferous tubules.
Journal of andrology 1992;13(2):172-84.
1992: Chris McKinnell; Richard M Sharpe
The role of specific germ cell types in modulation of the secretion of androgen-regulated proteins (ARPs) by stage VI-VIII seminiferous tubules from the adult rat.
Molecular and cellular endocrinology 1992;83(2-3):219-31.
1991: G Allenby; P M Foster; Richard M Sharpe
Evaluation of changes in the secretion of immunoactive inhibin by adult rat seminiferous tubules in vitro as an indicator of early toxicant action on spermatogenesis.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1991;16(4):710-24.
1991: Richard M Sharpe; J M Bartlett; G Allenby
Evidence for the control of testicular interstitial fluid volume in the rat by specific germ cell types.
The Journal of endocrinology 1991;128(3):359-67.
1991: G Allenby; P M Foster; Richard M Sharpe
Evidence that secretion of immunoactive inhibin by seminiferous tubules from the adult rat testis is regulated by specific germ cell types: correlation between in vivo and in vitro studies.
Endocrinology 1991;128(1):467-76.
1990: Richard M Sharpe
Intratesticular control of steroidogenesis.
Clinical endocrinology 1990;33(6):787-807.
1990: Richard M Sharpe; S Maddocks; J B Kerr
Cell-cell interactions in the control of spermatogenesis as studied using Leydig cell destruction and testosterone replacement.
The American journal of anatomy 1990;188(1):3-20.
1990: S Maddocks; Richard M Sharpe
The effects of sexual maturation and altered steroid synthesis on the production and route of secretion of inhibin-alpha from the rat testis.
Endocrinology 1990;126(3):1541-50.
1990: G Allenby; Richard M Sharpe; P M Foster
Changes in Sertoli cell function in vitro induced by nitrobenzene.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1990;14(2):364-75.
1989: S Maddocks; Richard M Sharpe
Assessment of the contribution of Leydig cells to the secretion of inhibin by the rat testis.
Molecular and cellular endocrinology 1989;67(1):113-8.
1989: Richard M Sharpe; S Maddocks
Evaluation of the relative importance of endocrine and paracrine factors in control of the levels of inhibin in testicular interstitial fluid.
International journal of andrology 1989;12(4):295-306.
1989: S Maddocks; Richard M Sharpe
Dynamics of testosterone secretion by the rat testis: implications for measurement of the intratesticular levels of testosterone.
The Journal of endocrinology 1989;122(1):323-9.
1989: J B Kerr; Richard M Sharpe
Focal disruption of spermatogenesis in the testis of adult rats after a single administration of human chorionic gonadotrophin.
Cell and tissue research 1989;257(1):163-9.
1989: Richard M Sharpe
Follicle-stimulating hormone and spermatogenesis in the adult male.
The Journal of endocrinology 1989;121(3):405-7.
1989: J B Kerr; Richard M Sharpe
Macrophage activation enhances the human chorionic gonadotrophin-induced disruption of spermatogenesis in the rat.
The Journal of endocrinology 1989;121(2):285-92.
1989: W D Ratnasooriya; Richard M Sharpe
Evaluation of the effect of selective germ cell depletion on subsequent spermatogenesis and fertility in the rat.
International journal of andrology 1989;12(1):44-57.
1989: S Maddocks; Richard M Sharpe
Interstitial fluid volume in the rat testis: androgen-dependent regulation by the seminiferous tubules?
The Journal of endocrinology 1989;120(2):215-22.
1989: S Maddocks; Richard M Sharpe
The route of secretion of inhibin from the rat testis.
The Journal of endocrinology 1989;120(1):R5-8.
1988: Richard M Sharpe; J B Kerr; S Maddocks
Evidence for a role of the Leydig cells in control of the intratesticular secretion of inhibin.
Molecular and cellular endocrinology 1988;60(2-3):243-7.
1988: Richard M Sharpe; Hamish M Fraser; W D Ratnasooriya
Assessment of the role of Leydig cell products other than testosterone in spermatogenesis and fertility in adult rats.
International journal of andrology 1988;11(6):507-23.
1988: Richard M Sharpe; I A Swanston; I Cooper; C G Tsonis; Alan S McNeilly
Factors affecting the secretion of immunoactive inhibin into testicular interstitial fluid in rats.
The Journal of endocrinology 1988;119(2):315-26.
1988: Richard M Sharpe
Bidirectional secretion by the Sertoli cell.
International journal of andrology 1988;11(2):87-91.
1988: Richard M Sharpe; K Donachie; I Cooper
Re-evaluation of the intratesticular level of testosterone required for quantitative maintenance of spermatogenesis in the rat.
The Journal of endocrinology 1988;117(1):19-26.
1988: J M Bartlett; J B Kerr; Richard M Sharpe
The selective removal of pachytene spermatocytes using methoxy acetic acid as an approach to the study in vivo of paracrine interactions in the testis.
Journal of andrology 1988;9(1):31-40.
1987: J M Bartlett; F C Wu; Richard M Sharpe
Enhancement of Leydig cell testosterone secretion by isolated seminiferous tubules during co-perifusion in vitro: comparison with static co-culture systems.
International journal of andrology 1987;10(4):603-17.
1987: J B Kerr; J M Bartlett; K Donachie; Richard M Sharpe
Origin of regenerating Leydig cells in the testis of the adult rat. An ultrastructural, morphometric and hormonal assay study.
Cell and tissue research 1987;249(2):367-77.
1986: Richard M Sharpe; J B Kerr; I Cooper; J M Bartlett
Intratesticular factors and testosterone secretion: the effect of treatment with ethane dimethanesulphonate (EDS) and the induction of seminiferous tubule damage.
International journal of andrology 1986;9(4):285-98.
1986: J M Bartlett; J B Kerr; Richard M Sharpe
The effect of selective destruction and regeneration of rat Leydig cells on the intratesticular distribution of testosterone and morphology of the seminiferous epithelium.
Journal of andrology 1986;7(4):240-53.
1986: Richard M Sharpe; J B Kerr; H M Fraser; J M Bartlett
Intratesticular factors and testosterone secretion. Effect of treatments that alter the level of testosterone within the testis.
Journal of andrology 1986;7(3):180-9.