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Norman Sharpless

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William R Jeck; Alex P Siebold; Norman E Sharpless
Review: a meta-analysis of GWAS and age-associated diseases.
Julie A E Nelson; Norman E Sharpless; Michael G Hudgens; Janakiraman Krishnamurthy; Yan Liu; Prema Menezes; Joseph J Eron
Expression of p16(INK4a) as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy.
Wenjin Liu; C Ryan Miller; Kimberly B Monahan; David W Ollila; Charles M Perou; Adam D Pfefferle; David W Roadcap; Takeshi Shimamura; Jessica Sorrentino; Nancy E Thomas; Kwok-Kin Wong; James E Bear; Diego H Castrillon; Keefe T Chan; Norman E Sharpless
LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.

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All Publications

2012: William R Jeck; Alex P Siebold; Norman E Sharpless
Review: a meta-analysis of GWAS and age-associated diseases.
Aging cell 2012;11(5):727-31.
2012: Julie A E Nelson; Norman E Sharpless; Michael G Hudgens; Janakiraman Krishnamurthy; Yan Liu; Prema Menezes; Joseph J Eron
Expression of p16(INK4a) as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy.
Aging cell 2012;11(5):916-8.
2012: Wenjin Liu; C Ryan Miller; Kimberly B Monahan; David W Ollila; Charles M Perou; Adam D Pfefferle; David W Roadcap; Takeshi Shimamura; Jessica Sorrentino; Nancy E Thomas; Kwok-Kin Wong; James E Bear; Diego H Castrillon; Keefe T Chan; Norman E Sharpless
LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.
Cancer cell 2012;21(6):751-64.
2012: James S Duncan; H Shelton Earp; Stephen V Frye; Shawn M Gomez; Deborah A Granger; Lee M Graves; Xiaping He; Katherine A Hoadley; Jian Jin; Nancy L Johnson; Nicole Vincent Jordan; William Y Kim; Pei-Fen Kuan; Ben Major; Alicia A Midland; Kazuhiro Nakamura; Charles M Perou; Norman E Sharpless; David M Smalley; Jerry Usary; Martin C Whittle; Jon S Zawistowski; Bing Zhou; Amy N Abell; Xin Chen; David B Darr; Gary L Johnson
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer.
Cell 2012;149(2):307-21.
2012: Patrick J Roberts; John E Bisi; Austin J Combest; David B Darr; Charles M Perou; Jay C Strum; Jerry E Usary; Kwok-Kin Wong; William C Zamboni; Norman E Sharpless
Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy.
Journal of the National Cancer Institute 2012;104(6):476-87.
2012: Congying Wu; Sreeja B Asokan; Matthew E Berginski; Shawn M Gomez; Jack D Griffith; Elizabeth M Haynes; Norman E Sharpless; James E Bear
Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis.
Cell 2012;148(5):973-87.
2012: Austin J Combest; Patrick M Dillon; Sohrab Habibi; Suzan K Hanna; Markus Müller; Patrick J Roberts; Charlene Ross; Katie Sandison; Norman E Sharpless; Beth A Zamboni; Martin Brunner; William C Zamboni
Genetically engineered cancer models, but not xenografts, faithfully predict anticancer drug exposure in melanoma tumors.
The oncologist 2012;17(10):1303-16.
2012: William Y Kim; Norman E Sharpless
Drug efficacy testing in mice.
Current topics in microbiology and immunology 2012;355():19-38.
2011: Jessica C Cardenas; A Phillip Owens; Janakiraman Krishnamurthy; Norman E Sharpless; Herbert C Whinna; Frank C Church
Overexpression of the cell cycle inhibitor p16INK4a promotes a prothrombotic phenotype following vascular injury in mice.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(4):827-33.
2010: P Dillon; N Thomas; Norman E Sharpless; Frances A Collichio
Regression of advanced melanoma upon withdrawal of immunosuppression: case series and literature review.
Medical oncology (Northwood, London, England) 2010;27(4):1127-32.
2010: K B Monahan; G I Rozenberg; Janakiraman Krishnamurthy; S M Johnson; W Liu; M K Bradford; J Horner; Ronald A DePinho; Norman E Sharpless
Somatic p16(INK4a) loss accelerates melanomagenesis.
Oncogene 2010;29(43):5809-17.
2010: Gabriela I Rozenberg; Kimberly B Monahan; Chad Torrice; James E Bear; Norman E Sharpless
Metastasis in an orthotopic murine model of melanoma is independent of RAS/RAF mutation.
Melanoma research 2010;20(5):361-71.
2010: Julian Carretero; Takeshi Shimamura; Klarisa Rikova; Autumn L Jackson; Matthew D Wilkerson; Christa L Borgman; Matthew S Buttarazzi; Benjamin A Sanofsky; Kate McNamara; Kathleyn A Brandstetter; Zandra E Walton; Ting-Lei Gu; Jeffrey C Silva; Katherine Crosby; Geoffrey I Shapiro; Sauveur-Michel Maira; Hongbin Ji; Diego H Castrillon; Carla F Kim; Carlos García-Echeverría; Nabeel Bardeesy; Norman E Sharpless; Neil D Hayes; William Y Kim; Jeffrey A Engelman; Kwok-Kin Wong
Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.
Cancer cell 2010;17(6):547-59.
2010: Christin E Burd; Norman E Sharpless
What's so special about RB?
Cancer cell 2010;17(4):313-4.
2010: Christin E Burd; William R Jeck; Yan Liu; Hanna Sanoff; Zefeng Wang; Norman E Sharpless
Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.
PLoS genetics 2010;6(12):e1001233.
2009: Denis Tsygankov; Yan Liu; Hanna Sanoff; Norman E Sharpless; Timothy C Elston
A quantitative model for age-dependent expression of the p16INK4a tumor suppressor.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(39):16562-7.
2009: William Kim; Samanthi Perera; Bing Zhou; Julian Carretero; Jen Jen Yeh; Samuel A Heathcote; Autumn L Jackson; Petros Nikolinakos; Beatriz Ospina; George Naumov; Kathleyn A Brandstetter; Victor J Weigman; Sara Zaghlul; David Hayes; Robert F Padera; John V Heymach; Andrew L Kung; Norman E Sharpless; William G Kaelin; Kwok-Kin Wong
HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice.
The Journal of clinical investigation 2009;119(8):2160-70.
2009: Yan Liu; Norman E Sharpless
Tumor suppressor mechanisms in immune aging.
Current opinion in immunology 2009;21(4):431-9.
2009: Yan Liu; Hanna Sanoff; Hyunsoon Cho; Christin E Burd; Chad Torrice; Joseph G Ibrahim; Nancy E Thomas; Norman E Sharpless
Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging.
Aging cell 2009;8(4):439-48.
2009: Esther Sook Miin Wong; Xavier Le Guezennec; Oleg N Demidov; Nicolette Theresa Marshall; Siew Tein Wang; Janakiraman Krishnamurthy; Norman E Sharpless; N Ray Dunn; Dmitry V Bulavin
p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age.
Developmental cell 2009;17(1):142-9.
2009: Norman E Sharpless; Gerald Schatten
Stem cell aging.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(2):202-4.
2009: Derek L Stirewalt; Y E Choi; Norman E Sharpless; E L Pogosova-Agadjanyan; M R Cronk; Michi Yukawa; Eric B Larson; B L Wood; F R Appelbaum; J P Radich; S Heimfeld
Decreased IRF8 expression found in aging hematopoietic progenitor/stem cells.
Leukemia 2009;23(2):391-3.
2009: Yan Liu; Hanna Sanoff; Hyunsoon Cho; Christin E Burd; Chad Torrice; Karen L Mohlke; Joseph G Ibrahim; Nancy E Thomas; Norman E Sharpless
INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis.
PloS one 2009;4(4):e5027.
2009: Shana N Wingo; Teresa D Gallardo; Esra A Akbay; Mei-Chi Liang; Cristina M Contreras; Todd Boren; Takeshi Shimamura; David S Miller; Norman E Sharpless; Nabeel Bardeesy; David J Kwiatkowski; John O Schorge; Kwok-Kin Wong; Diego H Castrillon
Somatic LKB1 mutations promote cervical cancer progression.
PloS one 2009;4(4):e5137.
2008: Scott M Hammond; Norman E Sharpless
HMGA2, microRNAs, and stem cell aging.
Cell 2008;135(6):1013-6.
2008: Wuping Li; Aravind Asokan; Zhijian Wu; Terry Van Dyke; Nina DiPrimio; Jarrod S Johnson; Lakshmanan Govindaswamy; Mavis Agbandje-McKenna; Stefan Leichtle; D Eugene Redmond; Thomas J McCown; Kimberly B Petermann; Norman E Sharpless; R Jude Samulski
Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticles.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(7):1252-60.
2008: Jin-Na Min; Ryan A Whaley; Norman E Sharpless; Pamela Lockyer; Andrea L Portbury; Winston Patterson
CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control.
Molecular and cellular biology 2008;28(12):4018-25.
2008: Usman Shah; Norman E Sharpless; David Hayes
LKB1 and lung cancer: more than the usual suspects.
Cancer research 2008;68(10):3562-5.
2008: William Kim; Norman E Sharpless
VHL inactivation: a new road to senescence.
Cancer cell 2008;13(4):295-7.
2008: William K Kaufmann; Kathleen R Nevis; Pingping Qu; Joseph G Ibrahim; Tong Zhou; Yingchun Zhou; Dennis A Simpson; Jennifer Helms-Deaton; Marila Cordeiro-Stone; Dominic T Moore; Nancy E Thomas; Honglin Hao; Zhi Liu; Janiel M Shields; Glynis A Scott; Norman E Sharpless
Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression.
The Journal of investigative dermatology 2008;128(1):175-87.
2007: Kimberly B Petermann; Gabriela I Rozenberg; Daniel Zedek; Pamela A Groben; Karen P McKinnon; Christin Buehler; William Kim; Janiel M Shields; Shannon Penland; James E Bear; Nancy E Thomas; Jonathan S Serody; Norman E Sharpless
CD200 is induced by ERK and is a potential therapeutic target in melanoma.
The Journal of clinical investigation 2007;117(12):3922-9.
2007: Norman E Sharpless; Ronald A DePinho
How stem cells age and why this makes us grow old.
Nature reviews. Molecular cell biology 2007;8(9):703-13.
2007: Hongbin Ji; Matthew Robert Ramsey; David Hayes; Cheng Fan; Kate McNamara; Piotr Kozlowski; Chad Torrice; Michael Wu; Takeshi Shimamura; Samanthi A Perera; Mei-Chih Liang; Dongpo Cai; George N Naumov; Lei Bao; Cristina M Contreras; Danan Li; Liang Chen; Janakiraman Krishnamurthy; Jussi Koivunen; Lucian R Chirieac; Robert F Padera; Roderick T Bronson; Neal I Lindeman; David C Christiani; Xihong Lin; Geoffrey I Shapiro; Pasi A Janne; Bruce E Johnson; Matthew Meyerson; David J Kwiatkowski; Diego H Castrillon; Nabeel Bardeesy; Norman E Sharpless; Kwok-Kin Wong
LKB1 modulates lung cancer differentiation and metastasis.
Nature 2007;448(7155):807-10.
2007: Linan Ha; Takeshi Ichikawa; Miriam R Anver; Ross Dickins; Scott W Lowe; Norman E Sharpless; Paul Krimpenfort; Ronald A DePinho; Dorothy C Bennett; Elena V Sviderskaya; Glenn Merlino
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):10968-73.
2007: Janakiraman Krishnamurthy; Norman E Sharpless
Stem cells and the rate of living.
Cell stem cell 2007;1(1):9-11.
2007: Matthew Robert Ramsey; Janakiraman Krishnamurthy; Zhijun Li; Chad Torrice; Weili Lin; Daniel R Carrasco; Keith L Ligon; Yue Xiong; Norman E Sharpless
Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues.
Cancer research 2007;67(10):4732-41.
2007: Shannon K Penland; Temitope Keku; Chad Torrice; Xiaping He; Janakiraman Krishnamurthy; Katherine A Hoadley; John T Woosley; Nancy E Thomas; Charles M Perou; Robert S Sandler; Norman E Sharpless
RNA expression analysis of formalin-fixed paraffin-embedded tumors.
Laboratory investigation; a journal of technical methods and pathology 2007;87(4):383-91.
2007: Janiel M Shields; Nancy E Thomas; Melissa Cregger; Aaron J Berger; Michael Leslie; Chad Torrice; Honglin Hao; Shannon Penland; Jack Arbiser; Glynis Scott; Tong Zhou; Menashe Bar-Eli; James E Bear; Channing J Der; William K Kaufmann; David L Rimm; Norman E Sharpless
Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma.
Cancer research 2007;67(4):1502-12.
2007: Norman E Sharpless; Ronald A DePinho
Cancer biology: gone but not forgotten.
Nature 2007;445(7128):606-7.
2007: Jessica F Bell; Norman E Sharpless
Telomeres, p21 and the cancer-aging hypothesis.
Nature genetics 2007;39(1):11-2.
2006: Nabeel Bardeesy; Norman E Sharpless
RAS unplugged: negative feedback and oncogene-induced senescence.
Cancer cell 2006;10(6):451-3.
2006: Matthew Robert Ramsey; Norman E Sharpless
ROS as a tumour suppressor?
Nature cell biology 2006;8(11):1213-5.
2006: William Kim; Norman E Sharpless
The regulation of INK4/ARF in cancer and aging.
Cell 2006;127(2):265-75.
2006: Anna V Molofsky; Shalom G Slutsky; Nancy M Joseph; Shenghui He; Ricardo Pardal; Janakiraman Krishnamurthy; Norman E Sharpless; Sean J Morrison
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing.
Nature 2006;443(7110):448-52.
2006: Janakiraman Krishnamurthy; Matthew Robert Ramsey; Keith L Ligon; Chad Torrice; Angela Koh; Susan Bonner-Weir; Norman E Sharpless
p16INK4a induces an age-dependent decline in islet regenerative potential.
Nature 2006;443(7110):453-7.
2006: Viktor Janzen; Randolf Forkert; Heather E Fleming; Yoriko Saito; Michael T Waring; David Dombkowski; Tao Cheng; Ronald A DePinho; Norman E Sharpless; David T Scadden
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.
Nature 2006;443(7110):421-6.
2006: Hongbin Ji; Norman E Sharpless; Kwok-Kin Wong
EGFR targeted therapy: view from biological standpoint.
Cell cycle (Georgetown, Tex.) 2006;5(18):2072-6.
2006: Norman E Sharpless; Ronald A DePinho
The mighty mouse: genetically engineered mouse models in cancer drug development.
Nature reviews. Drug discovery 2006;5(9):741-54.
2006: Hongbin Ji; Danan Li; Liang Chen; Takeshi Shimamura; Susumu Kobayashi; Kate McNamara; Umar Mahmood; Albert Mitchell; Yangping Sun; Ruqayyah Al-Hashem; Lucian R Chirieac; Robert F Padera; Roderick T Bronson; William Kim; Pasi A Janne; Geoffrey I Shapiro; Daniel Tenen; Bruce E Johnson; Ralph Weissleder; Norman E Sharpless; Kwok-Kin Wong
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.
Cancer cell 2006;9(6):485-95.
2006: Seema Paliwal; Sandhya Pande; Ramesh Kovi; Norman E Sharpless; Nabeel Bardeesy; Steven R Grossman
Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis.
Molecular and cellular biology 2006;26(6):2360-72.
2005: Steven L Gibson; Amelie Boquoi; Tina Chen; Norman E Sharpless; Colleen Brensinger; Greg H Enders
p16(Ink4a) inhibits histologic progression and angiogenic signaling in min colon tumors.
Cancer biology & therapy 2005;4(12):1389-94.
2005: Norman E Sharpless
INK4a/ARF: a multifunctional tumor suppressor locus.
Mutation research 2005;576(1-2):22-38.
2005: Norman E Sharpless; Ronald A DePinho
Cancer: crime and punishment.
Nature 2005;436(7051):636-7.
2005: Thomas M. Ruenger; Irene Vergilis; Papri Sarkar; Ronald A DePinho; Norman E Sharpless
How disruption of cell cycle regulating genes might predispose to sun-induced skin cancer.
Cell cycle (Georgetown, Tex.) 2005;4(5):643-5.
2004: Papri Sarkar-Agrawal; Irene Vergilis; Norman E Sharpless; Ronald A DePinho; Thomas M. Ruenger
Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF.
Journal of the National Cancer Institute 2004;96(23):1790-3.
2004: Norman E Sharpless
Ink4a/Arf links senescence and aging.
Experimental gerontology 2004;39(11-12):1751-9.
2004: Janakiraman Krishnamurthy; Chad Torrice; Matthew Robert Ramsey; Grigoriy I Kovalev; Khalid A Al-Regaiey; Lishan Su; Norman E Sharpless
Ink4a/Arf expression is a biomarker of aging.
The Journal of clinical investigation 2004;114(9):1299-307.
2004: J Eric Turner; John G Alley; Norman E Sharpless
Medical problems in patients with malignancy: case 2. Wernicke's encephalopathy: an unusual acute neurologic complication of lymphoma and its therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(19):4020-2.
2004: Scott T Magness; Humberto B Jijon; Nancy Van Houten Fisher; Norman E Sharpless; David A Brenner; Christian Jobin
In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1561-70.
2004: Zohar Sachs; Norman E Sharpless; Ronald A DePinho; Naomi Rosenberg
p16(Ink4a) interferes with Abelson virus transformation by enhancing apoptosis.
Journal of virology 2004;78(7):3304-11.
2004: Norman E Sharpless; Matthew Robert Ramsey; Periasamy Balasubramanian; Diego H Castrillon; Ronald A DePinho
The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.
Oncogene 2004;23(2):379-85.
2004: Norman E Sharpless; Ronald A DePinho
Telomeres, stem cells, senescence, and cancer.
The Journal of clinical investigation 2004;113(2):160-8.
2003: Rónán C O'Hagan; Cameron Brennan; Andrew Strahs; Xuegong Zhang; Karuppiah Kannan; Melissa Donovan; Craig Cauwels; Norman E Sharpless; Wing Hung Wong; Lynda Chin
Array comparative genome hybridization for tumor classification and gene discovery in mouse models of malignant melanoma.
Cancer research 2003;63(17):5352-6.
2003: Norman E Sharpless
The persistence of senescence.
Science of aging knowledge environment : SAGE KE 2003;2003(33):PE24.
2003: Norman E Sharpless; Karuppiah Kannan; Jin Xu; Marcus W Bosenberg; Lynda Chin
Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo.
Oncogene 2003;22(32):5055-9.
2003: Karuppiah Kannan; Norman E Sharpless; Jin Xu; Rónán C O'Hagan; Marcus W Bosenberg; Lynda Chin
Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1221-5.
2002: Nabeel Bardeesy; Manisha Sinha; Aram F Hezel; Sabina Signoretti; Nathaniel A Hathaway; Norman E Sharpless; Massimo Loda; Daniel R Carrasco; Ronald A DePinho
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation.
Nature 2002;419(6903):162-7.
2002: Matthew H Kulke; George D Demetri; Norman E Sharpless; David P Ryan; Ramesh A Shivdasani; Jeffrey S Clark; Bruce M Spiegelman; Haesook T Kim; Robert J Mayer; Charlie S Fuchs
A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer.
Cancer journal (Sudbury, Mass.) 2002;8(5):395-9.
2002: Oliver G Opitz; Hideki Harada; Yasir Suliman; Ben Rhoades; Norman E Sharpless; Ralph Kent; Levy Kopelovich; Hiroshi Nakagawa; Anil K Rustgi
A mouse model of human oral-esophageal cancer.
The Journal of clinical investigation 2002;110(6):761-9.
2002: Norman E Sharpless; Ronald A DePinho
p53: good cop/bad cop.
Cell 2002;110(1):9-12.
2002: Steven E Artandi; Scott Alson; Maja K Tietze; Norman E Sharpless; Siqin Ye; Roger A. Greenberg; Diego H Castrillon; James W Horner; Sarah R Weiler; Ruben D Carrasco; Ronald A DePinho
Constitutive telomerase expression promotes mammary carcinomas in aging mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8191-6.
2002: Norman E Sharpless; Scott Alson; Suzanne Chan; Daniel P Silver; Diego H Castrillon; Ronald A DePinho
p16(INK4a) and p53 deficiency cooperate in tumorigenesis.
Cancer research 2002;62(10):2761-5.
2002: Robert M Bachoo; Elizabeth A Maher; Keith L Ligon; Norman E Sharpless; Suzanne S Chan; Mingjian James You; Yi Tang; Jessica DeFrances; Elizabeth Stover; Ralph Weissleder; David H Rowitch; David N Louis; Ronald A DePinho
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.
Cancer cell 2002;1(3):269-77.
2001: Norman E Sharpless; David O Ferguson; Rónán C O'Hagan; Diego H Castrillon; C Lee; P A Farazi; Scott Alson; J Fleming; C C Morton; K Frank; Lynda Chin; Frederick W Alt; Ronald A DePinho
Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.
Molecular cell 2001;8(6):1187-96.
2001: Norman E Sharpless; Nabeel Bardeesy; K H Lee; Daniel R Carrasco; Diego H Castrillon; Andrew J Aguirre; E A Wu; James W Horner; Ronald A DePinho
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.
Nature 2001;413(6851):86-91.
2001: Nabeel Bardeesy; Norman E Sharpless; Ronald A DePinho; Glenn Merlino
The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model.
Seminars in cancer biology 2001;11(3):201-18.
2001: F Martelli; T Hamilton; Daniel P Silver; Norman E Sharpless; Nabeel Bardeesy; M Rokas; Ronald A DePinho; David M Livingston; Steven R Grossman
p19ARF targets certain E2F species for degradation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4455-60.
2000: KM Frank; Norman E Sharpless; Yijie Gao; JoAnn Sekiguchi; David O Ferguson; Chengming Zhu; John P Manis; J Horner; Ronald A DePinho; Frederick W Alt
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway.
Molecular cell 2000;5(6):993-1002.
2000: David O Ferguson; JoAnn Sekiguchi; KM Frank; Y Gao; Norman E Sharpless; Yansong Gu; John P Manis; Ronald A DePinho; Frederick W Alt
The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis.
Cold Spring Harbor symposia on quantitative biology 2000;65():395-403.
1999: Norman E Sharpless; Ronald A DePinho
The INK4A/ARF locus and its two gene products.
Current opinion in genetics & development 1999;9(1):22-30.
1998: RT Penson; K E Shannon; Norman E Sharpless; Michael Seiden
Ovarian cancer: an update on genetics and therapy.
Comprehensive therapy 1998;24(10):477-87.
1992: Norman E Sharpless; D Gilbert; B Vandercam; J M Zhou; Eric Verdin; Gabriele V Ronnett; E Friedman; Monique Dubois-Dalcq
The restricted nature of HIV-1 tropism for cultured neural cells.
Virology 1992;191(2):813-25.
1992: Norman E Sharpless; William A O'Brien; Eric Verdin; Conrad Kufta; I S Chen; Monique Dubois-Dalcq
Human immunodeficiency virus type 1 tropism for brain microglial cells is determined by a region of the env glycoprotein that also controls macrophage tropism.
Journal of virology 1992;66(4):2588-93.