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Michele Sharr

Research Profile

Chemicals & Drugs

Concepts & Ideas

Structure-Activity Relationship

Anatomy

Cartilage

Living Beings

Disorders

Osteoarthritis

Co-author Network

Publications

TOP 3
Venkatesan Aranapakam; Jamie M Davis; George T Grosu; Jannie Baker; John W Ellingboe; Arie Zask; Jeremy I Levin; Vincent P Sandanayaka; Mila Du; Jerauld S Skotnicki; John F DiJoseph; Amy Sung; Michele A Sharr; Loran M Killar; Thomas Walter; Guixian Jin; Rebecca Cowling; Jeff Tillett; Weiguang Zhao; Joseph McDevitt; Zhang B Xu
Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Venkatesan Aranapakam; George T Grosu; Jamie M Davis; Baihua Hu; John W Ellingboe; Jannie L Baker; Jerauld S Skotnicki; Arie Zask; John F DiJoseph; Amy Sung; Michele A Sharr; Loran M Killar; Thomas Walter; Guixian Jin; Rebecca Cowling
Synthesis and structure-activity relationship of alpha-sulfonylhydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Arie Zask; Y Gu; J Donald Albright; Xumei Du; M Hogan; Jeremy I Levin; James M Chen; Loran M Killar; Amy Sung; John F DiJoseph; Michele A Sharr; Catherine E Roth; S Skala; Guixian Jin; Rebecca Cowling; Ken Mohler; Dauphine Barone; Roy Black; CJ March; Jerauld S Skotnicki
Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors.

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All Publications

2003: Venkatesan Aranapakam; Jamie M Davis; George T Grosu; Jannie Baker; John W Ellingboe; Arie Zask; Jeremy I Levin; Vincent P Sandanayaka; Mila Du; Jerauld S Skotnicki; John F DiJoseph; Amy Sung; Michele A Sharr; Loran M Killar; Thomas Walter; Guixian Jin; Rebecca Cowling; Jeff Tillett; Weiguang Zhao; Joseph McDevitt; Zhang B Xu
Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Journal of medicinal chemistry 2003;46(12):2376-96.
2003: Venkatesan Aranapakam; George T Grosu; Jamie M Davis; Baihua Hu; John W Ellingboe; Jannie L Baker; Jerauld S Skotnicki; Arie Zask; John F DiJoseph; Amy Sung; Michele A Sharr; Loran M Killar; Thomas Walter; Guixian Jin; Rebecca Cowling
Synthesis and structure-activity relationship of alpha-sulfonylhydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Journal of medicinal chemistry 2003;46(12):2361-75.
2003: Arie Zask; Y Gu; J Donald Albright; Xumei Du; M Hogan; Jeremy I Levin; James M Chen; Loran M Killar; Amy Sung; John F DiJoseph; Michele A Sharr; Catherine E Roth; S Skala; Guixian Jin; Rebecca Cowling; Ken Mohler; Dauphine Barone; Roy Black; CJ March; Jerauld S Skotnicki
Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(8):1487-90.
2002: Frances C Nelson; Efren Delos Santos; Jeremy I Levin; James M Chen; Jerauld S Skotnicki; John F DiJoseph; Michele A Sharr; Amy Sung; Loran M Killar; Rebecca Cowling; Guixian Jin; Catherine E Roth; J Donald Albright
Benzodiazepine inhibitors of the MMPs and TACE.
Bioorganic & medicinal chemistry letters 2002;12(20):2867-70.
2001: Jeremy I Levin; James M Chen; Mila T Du; Frances C Nelson; T Wehr; John F DiJoseph; Loran M Killar; S Skala; Amy Sung; Michele A Sharr; Catherine E Roth; Guixian Jin; Rebecca Cowling; L Di; M Sherman; Zhang B Xu; CJ March; Ken Mohler; Roy A Black; Jerauld S Skotnicki
The discovery of anthranilic acid-based MMP inhibitors. Part 3: incorporation of basic amines.
Bioorganic & medicinal chemistry letters 2001;11(22):2975-8.
2001: Jeremy I Levin; J Chen; Mila Du; M Hogan; S Kincaid; Frances C Nelson; Aranapakam M Venkatesan; T Wehr; Arie Zask; John F DiJoseph; Loran M Killar; S Skala; Amy Sung; Michele A Sharr; C Roth; Guixian Jin; Rebecca Cowling; Ken Mohler; Roy A Black; CJ March; Jerauld S Skotnicki
The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups.
Bioorganic & medicinal chemistry letters 2001;11(16):2189-92.
2001: Jeremy I Levin; Y Gu; Frances C Nelson; Arie Zask; John F DiJoseph; Michele A Sharr; Amy Sung; Guixian Jin; Rebecca Cowling; Pranab K Chanda; Scott Cosmi; C L Hsiao; Wade Edris; James Wilhelm; Loran M Killar; Jerauld S Skotnicki
Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 2001;11(2):239-42.
2001: Jeremy I Levin; Mila T Du; John F DiJoseph; Loran M Killar; Amy Sung; Thomas Walter; Michele A Sharr; Catherine E Roth; Franklin J Moy; Robert Powers; Guixian Jin; Rebecca Cowling; Jerauld S Skotnicki
The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position.
Bioorganic & medicinal chemistry letters 2001;11(2):235-8.
1998: Jeremy I Levin; John F DiJoseph; Loran M Killar; Amy Sung; Thomas Walter; Michele A Sharr; Catherine E Roth; Jerauld S Skotnicki; J Donald Albright
The synthesis and biological activity of a novel series of diazepine MMP inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(19):2657-62.
1998: Jeremy I Levin; John F DiJoseph; Loran M Killar; Michele A Sharr; Jerauld S Skotnicki; Dinesh V Patel; Xiao-Yi Xiao; L Shi; M Navre; DA Campbell
The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 1998;8(10):1163-8.
1998: DA Campbell; Xiao-Yi Xiao; D Harris; S Ida; R Mortezaei; K Ngu; L Shi; D Tien; Y Wang; M Navre; Dinesh V Patel; Michele A Sharr; John F DiJoseph; Loran M Killar; C L Leone; Jeremy I Levin; Jerauld S Skotnicki
Malonyl alpha-mercaptoketones and alpha-mercaptoalcohols, a new class of matrix metalloproteinase inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(10):1157-62.
1996: John F DiJoseph; E Fluhler; J Armstrong; Michele A Sharr; S N Sehgal
Therapeutic blood levels of sirolimus (rapamycin) in the allografted rat.
Transplantation 1996;62(8):1109-12.