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Susan Sharrow

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Xuguang Tai; Craig B Thompson; François Van Laethem; Anthony Adams; Lionel Feigenbaum; Larry Granger; Terry I Guinter; Michael J Kruhlak; Tullia Lindsten; Leonid Pobezinsky; Susan O Sharrow; Alfred Singer
Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.
Sophia D Sarafova; François Van Laethem; Stanley Adoro; Terry I Guinter; Susan O Sharrow; Lionel Feigenbaum; Alfred Singer
Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.
François Van Laethem; Sophia D Sarafova; Jung-Hyun Park; Xuguang Tai; Leonid Pobezinsky; Terry I Guinter; Stanley Adoro; Anthony Adams; Susan O Sharrow; Lionel Feigenbaum; Alfred Singer
Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.

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2012: Xuguang Tai; Craig B Thompson; François Van Laethem; Anthony Adams; Lionel Feigenbaum; Larry Granger; Terry I Guinter; Michael J Kruhlak; Tullia Lindsten; Leonid Pobezinsky; Susan O Sharrow; Alfred Singer
Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.
Blood 2012;119(22):5155-63.
2009: Sophia D Sarafova; François Van Laethem; Stanley Adoro; Terry I Guinter; Susan O Sharrow; Lionel Feigenbaum; Alfred Singer
Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.
Immunity 2009;31(3):480-90.
2007: François Van Laethem; Sophia D Sarafova; Jung-Hyun Park; Xuguang Tai; Leonid Pobezinsky; Terry I Guinter; Stanley Adoro; Anthony Adams; Susan O Sharrow; Lionel Feigenbaum; Alfred Singer
Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.
Immunity 2007;27(5):735-50.
2006: Batu Erman; Amala S Alag; Oyvind Dahle; François Van Laethem; Sophia D Sarafova; Terry I Guinter; Susan O Sharrow; Alexander Grinberg; Paul E Love; Alfred Singer
Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6613-25.
2005: Sophia D Sarafova; Batu Erman; Qing Yu; François Van Laethem; Terry I Guinter; Susan O Sharrow; Lionel Feigenbaum; Kathryn F Wildt; Wilfried Ellmeier; Alfred Singer
Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.
Immunity 2005;23(1):75-87.
2004: Nahed el-Kassar; Philip J Lucas; David B Klug; Monica Zamisch; Melinda Merchant; Catherine V Bare; Baishakhi Choudhury; Susan O Sharrow; Ellen R Richie; CRYSTAL MACKALL; Ronald E Gress
A dose effect of IL-7 on thymocyte development.
Blood 2004;104(5):1419-27.
2004: Yu-Waye Chu; Sarfraz A Memon; Susan O Sharrow; Frances T Hakim; Michael Eckhaus; Philip J Lucas; Ronald E Gress
Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function.
Blood 2004;104(4):1110-9.
2003: Rémy Bosselut; Terry I Guinter; Susan O Sharrow; Alfred Singer
Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells.
The Journal of experimental medicine 2003;197(12):1709-19.
2003: Qing Yu; Batu Erman; Avinash Bhandoola; Susan O Sharrow; Alfred Singer
In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells.
The Journal of experimental medicine 2003;197(4):475-87.
2002: Susan O Sharrow
Overview of flow cytometry.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2002;Chapter 5():Unit 5.1.
2002: Joy A Williams; Susan O Sharrow; Anthony J Adams; Richard J Hodes
CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2759-65.
2001: Susan O Sharrow
Analysis of flow cytometry data.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 5():Unit 5.2.
2001: Rémy Bosselut; Lionel Feigenbaum; Susan O Sharrow; Alfred Singer
Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes.
Immunity 2001;14(4):483-94.
2001: David J McKean; Catherine J Huntoon; Michael P Bell; X Tai; Susan O Sharrow; KE Hedin; A Conley; Alfred Singer
Maturation versus death of developing double-positive thymocytes reflects competing effects on Bcl-2 expression and can be regulated by the intensity of CD28 costimulation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3468-75.
2000: E Brugnera; Avinash Bhandoola; Ricardo Cibotti; Qing Yu; Terry I Guinter; Y Yamashita; Susan O Sharrow; Alfred Singer
Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells.
Immunity 2000;13(1):59-71.
2000: Ricardo Cibotti; Avinash Bhandoola; Terry I Guinter; Susan O Sharrow; Alfred Singer
CD8 coreceptor extinction in signaled CD4(+)CD8(+) thymocytes: coordinate roles for both transcriptional and posttranscriptional regulatory mechanisms in developing thymocytes.
Molecular and cellular biology 2000;20(11):3852-9.
1999: Avinash Bhandoola; Ricardo Cibotti; JA Punt; Larry Granger; A J Adams; Susan O Sharrow; Alfred Singer
Positive selection as a developmental progression initiated by alpha beta TCR signals that fix TCR specificity prior to lineage commitment.
Immunity 1999;10(3):301-11.
1997: Sándor Damjanovich; László Bene; János Matkó; A Alileche; Carolyn K Goldman; Susan O Sharrow; Thomas Waldmann
Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: a fluorescence resonance energy transfer study.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13134-9.
1997: W Wu; JA Punt; Larry Granger; Susan O Sharrow; Kelly P Kearse
Developmentally regulated expression of peanut agglutinin (PNA)-specific glycans on murine thymocytes.
Glycobiology 1997;7(3):349-56.
1997: Ricardo Cibotti; JA Punt; K S Dash; Susan O Sharrow; Alfred Singer
Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals.
Immunity 1997;6(3):245-55.
1996: JA Punt; H Suzuki; Larry Granger; Susan O Sharrow; Alfred Singer
Lineage commitment in the thymus: only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis.
The Journal of experimental medicine 1996;184(6):2091-9.
1996: W Wu; P H Harley; JA Punt; Susan O Sharrow; Kelly P Kearse
Identification of CD8 as a peanut agglutinin (PNA) receptor molecule on immature thymocytes.
The Journal of experimental medicine 1996;184(2):759-64.
1996: CRYSTAL MACKALL; C V Bare; L A Granger; Susan O Sharrow; J A Titus; Ronald E Gress
Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(12):4609-16.
1995: J L Roberts; Susan O Sharrow; A Singer
Disruption of intrathymic CD4-Ia interactions on immature CD4+CD8+ thymocytes results in diminished TCR expression on mature CD8+ T cell progeny.
Cellular immunology 1995;161(1):22-7.
1995: Kelly P Kearse; Y Takahama; JA Punt; Susan O Sharrow; Alfred Singer
Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection.
The Journal of experimental medicine 1995;181(1):193-202.
1994: P Benveniste; Y Takahama; David L. Wiest; T Nakayama; Susan O Sharrow; Alfred Singer
Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4+CD8+ thymocytes into mature T cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):6933-7.
1994: Susan O Sharrow; L A Barden; Alfred Singer; Stephen I Katz
Quantitative differences in cell surface expression of class I MHC antigens on murine epidermal Langerhans cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):110-6.
1994: M G Lee; Susan O Sharrow; Andrew G Farr; Alfred Singer; Mark C Udey
Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(12):5653-9.
1994: JA Punt; B A Osborne; Y Takahama; Susan O Sharrow; Alfred Singer
Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.
The Journal of experimental medicine 1994;179(2):709-13.
1993: Melanie S Vacchio; Larry Granger; O Kanagawa; B Malissen; K Tomonari; Susan O Sharrow; Richard J Hodes
T cell receptor V alpha-V beta combinatorial selection in the expressed T cell repertoire.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1322-7.
1993: E W Shores; T Nakayama; David L. Wiest; Y Takahama; Susan O Sharrow; Alfred Singer
Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCR beta transgene.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(4):1263-75.
1993: E Park; N Shinohara; J S Arn; Susan O Sharrow; G L Waneck; D H Sacks
Antigenic heterogeneity of Qa-2 antigens in C57BL/6.
Microbiology and immunology 1993;37(9):743-52.
1992: kevin horgan; G E Luce; Y Tanaka; T Schweighoffer; Yoji Shimizu; Susan O Sharrow; S Shaw
Differential expression of VLA-alpha 4 and VLA-beta 1 discriminates multiple subsets of CD4+CD45R0+ "memory" T cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(12):4082-7.
1992: Chou-Chik Ting; M E Hargrove; S M Liang; C M Liang; Susan O Sharrow
Dichotomy of glutathione regulation of the activation of resting and preactivated lymphocytes.
Cellular immunology 1992;142(1):40-53.
1992: P J Berlin; J D Bacher; Susan O Sharrow; C Gonzalez; Ronald E Gress
Monoclonal antibodies against human T cell adhesion molecules--modulation of immune function in nonhuman primates.
Transplantation 1992;53(4):840-9.
1992: Karen S Hathcock; G Laszlo; H B Dickler; Susan O Sharrow; P Johnson; I S Trowbridge; Richard J Hodes
Expression of variable exon A-, B-, and C-specific CD45 determinants on peripheral and thymic T cell populations.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(1):19-28.
1991: Y Takahama; Susan O Sharrow; Alfred Singer
Expression of an unusual T cell receptor (TCR)-V beta repertoire by Ly-6C+ subpopulations of CD4+ and/or CD8+ thymocytes. Evidence for a developmental relationship between Ly-6C+ thymocytes and CD4-CD8-TCR-alpha beta+ thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):2883-91.
1991: E W Shores; Susan O Sharrow; Alfred Singer
Presence of CD4 and CD8 determinants on CD4-CD8- murine thymocytes: passive acquisition of CD8 accessory molecules.
European journal of immunology 1991;21(4):973-7.
1991: Frances T Hakim; Susan O Sharrow; S Payne; Gene M Shearer
Repopulation of host lymphohematopoietic systems by donor cells during graft-versus-host reaction in unirradiated adult F1 mice injected with parental lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2108-15.
1991: R Guy; M Foo-Philips; Susan O Sharrow; Richard J Hodes
Subpopulations of fetal thymocytes defined by expression of T cell receptor/CD3 and IL-2 receptor. CD3 and IL-2 receptor alpha-chain are expressed on reciprocal cell populations.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(2):418-24.
1990: T Nakayama; Carl H June; T I Munitz; M Sheard; S A McCarthy; Susan O Sharrow; Lawrence E Samelson; Alfred Singer
Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4.
Science (New York, N.Y.) 1990;249(4976):1558-61.
1990: J L Roberts; Susan O Sharrow; Alfred Singer
Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities.
The Journal of experimental medicine 1990;171(3):935-40.
1990: E W Shores; Susan O Sharrow; I Uppenkamp; Alfred Singer
T cell receptor-negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway.
European journal of immunology 1990;20(1):69-77.
1989: Richard J Hodes; Susan O Sharrow; A Solomon
Failure of T cell receptor V beta negative selection in an athymic environment.
Science (New York, N.Y.) 1989;246(4933):1041-4.
1989: A Kosugi; J C Zuniga-Pflucker; Susan O Sharrow; A M Kruisbeek; Gene M Shearer
Effect of cyclosporin A on lymphopoiesis. II. Developmental defects of immature and mature thymocytes in fetal thymus organ cultures treated with cyclosporin A.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(10):3134-40.
1989: R D Moses; Susan O Sharrow; D A Stephany; K S Orr; Ronald E Gress
Cardiac allograft survival across major histocompatibility complex barriers in the rhesus monkey following T lymphocyte-depleted autologous marrow transplantation. IV. Immune reconstitution.
Transplantation 1989;48(5):774-81.
1989: J A Cole; S A McCarthy; M A Rees; Susan O Sharrow; Alfred Singer
Cell surface comodulation of CD4 and T cell receptor by anti-CD4 monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(2):397-402.
1989: M Fukuzawa; Susan O Sharrow; Gene M Shearer
Effect of cyclosporin A on T cell immunity. II. Defective thymic education of CD4 T helper cell function in cyclosporin A-treated mice.
European journal of immunology 1989;19(6):1147-52.
1989: Susan O Sharrow; J S Arn; I Stroynowski; L Hood; D H Sachs
Epitope clusters of Qa-2 antigens defined by a panel of new monoclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(10):3495-502.
1989: A Kosugi; Susan O Sharrow; Gene M Shearer
Effect of cyclosporin A on lymphopoiesis. I. Absence of mature T cells in thymus and periphery of bone marrow transplanted mice treated with cyclosporin A.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(9):3026-32.
1989: T I Munitz; Jonathan P Schneck; John E Coligan; W L Maloy; J P Henrich; Susan O Sharrow; David Margulies; Alfred Singer
A peptide derived from the alpha-helical region of class I MHC blocks CTL engagement of the class I MHC molecule.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():557-61.
1988: S A McCarthy; A M Kruisbeek; I K Uppenkamp; Susan O Sharrow; Alfred Singer
Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes.
Nature 1988;336(6194):76-9.
1988: Thomas Waldmann; Carolyn K Goldman; K F Bongiovanni; Susan O Sharrow; Michael P Davey; Kemp B Cease; S J Greenberg; Dan Longo
Therapy of patients with human T-cell lymphotrophic virus I-induced adult T-cell leukemia with anti-Tac, a monoclonal antibody to the receptor for interleukin-2.
Blood 1988;72(5):1805-16.
1988: E Kaldjian; S A McCarthy; Susan O Sharrow; Dan R Littman; Richard D Klausner; Alfred Singer
Nonequivalent effects of PKC activation by PMA on murine CD4 and CD8 cell-surface expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1988;2(12):2801-6.
1988: T Mizuochi; L Tentori; Susan O Sharrow; A M Kruisbeek; Alfred Singer
Differentiation of Ia-reactive CD8+ murine T cells does not require Ia engagement. Implications for the role of CD4 and CD8 accessory molecules in T cell differentiation.
The Journal of experimental medicine 1988;168(1):437-42.
1988: M Moser; Susan O Sharrow; Gene M Shearer
Role of L3T4+ and Lyt-2+ donor cells in graft-versus-host immune deficiency induced across a class I, class II, or whole H-2 difference.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(8):2600-8.
1988: M E Sanders; M W Makgoba; Susan O Sharrow; D Stephany; Timothy A Springer; H A Young; S Shaw
Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(5):1401-7.
1987: S Shimada; S Wright Caughman; Susan O Sharrow; D Stephany; Stephen I Katz
Enhanced antigen-presenting capacity of cultured Langerhans' cells is associated with markedly increased expression of Ia antigen.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2551-5.
1986: S Wright Caughman; Susan O Sharrow; S Shimada; D Stephany; T Mizuochi; A S Rosenberg; Stephen I Katz; A Singer
Ia+ murine epidermal Langerhans cells are deficient in surface expression of the class I major histocompatibility complex.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(19):7438-42.
1986: S W Caughman; S M Breathnach; Susan O Sharrow; D A Stephany; Stephen I Katz
Culture and characterization of murine dendritic Thy-1+ epidermal cells.
The Journal of investigative dermatology 1986;86(6):615-24.
1984: Thomas Waldmann; C K Goldman; R J Robb; J M Depper; Warren J Leonard; Susan O Sharrow; K F Bongiovanni; S J Korsmeyer; Warner Greene
Expression of interleukin 2 receptors on activated human B cells.
The Journal of experimental medicine 1984;160(5):1450-66.