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Gray Shaw

Research Profile

Chemicals & Drugs

Living Beings

Disorders

Anatomy

Kidneys

Procedures

Physiology

Graft Survival

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Publications

TOP 3
Adrian Huang; Alessandro Moretto; Kristin Janz; Michael Lowe; Patricia W Bedard; Steve Tam; Li Di; Valerie Clerin; Natalia Sushkova; Boris Tchernychev; Desiree H H Tsao; James Carl Keith; Gray D Shaw; Robert G Schaub; Qin Wang; Neelu Kaila
Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.
Susan Adam Benard; Thomas M Smith; Kristina Cunningham; Jaison Jacob; Thamara DeSilva; Laura Lin; Gray D Shaw; Ron Kriz; Kerry S Kelleher
Identification of peptide antagonists to glycoprotein Ibalpha that selectively inhibit von Willebrand factor dependent platelet aggregation.
Ulrich Y Schaff; Heather H Shih; Meike Lorenz; Dianne Sako; Ron Kriz; Kim Milarski; Brian Bates; Boris Tchernychev; Gray D Shaw; Scott I Simon
SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1.

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All Publications

2010: Adrian Huang; Alessandro Moretto; Kristin Janz; Michael Lowe; Patricia W Bedard; Steve Tam; Li Di; Valerie Clerin; Natalia Sushkova; Boris Tchernychev; Desiree H H Tsao; James Carl Keith; Gray D Shaw; Robert G Schaub; Qin Wang; Neelu Kaila
Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.
Journal of medicinal chemistry 2010;53(16):6003-17.
2008: Susan Adam Benard; Thomas M Smith; Kristina Cunningham; Jaison Jacob; Thamara DeSilva; Laura Lin; Gray D Shaw; Ron Kriz; Kerry S Kelleher
Identification of peptide antagonists to glycoprotein Ibalpha that selectively inhibit von Willebrand factor dependent platelet aggregation.
Biochemistry 2008;47(16):4674-82.
2008: Ulrich Y Schaff; Heather H Shih; Meike Lorenz; Dianne Sako; Ron Kriz; Kim Milarski; Brian Bates; Boris Tchernychev; Gray D Shaw; Scott I Simon
SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1.
European journal of immunology 2008;38(2):550-64.
2008: Patricia W Bedard; Valerie Clerin; Natalia Sushkova; Boris Tchernychev; Thomas Antrilli; Christine Resmini; James Carl Keith; James K Hennan; Neelu Kaila; Silvano DeBernardo; Kristin Janz; Qin Wang; David L Crandall; Robert G Schaub; Gray D Shaw; Laura L Carter
Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis.
The Journal of pharmacology and experimental therapeutics 2008;324(2):497-506.
2007: Michael Wadanoli; Dianne Sako; Gray D Shaw; Robert G Schaub; Qin Wang; Boris Tchernychev; Jin Xu; Thomas J Porter; Qinheng Huang
The von Willebrand factor antagonist (GPG-290) prevents coronary thrombosis without prolongation of bleeding time.
Thrombosis and haemostasis 2007;98(2):397-405.
2007: Daniel Durant Myers Jr; Shirley K Wrobleski; Christopher Longo; Patricia W Bedard; Neelu Kaila; Gray D Shaw; Frank J Londy; Suzan E Rohrer; Beverly Fex; Paul J Zajkowski; Thomas R Meier; Angela E Hawley; Diana M Farris; Nicole E Ballard; Peter K Henke; Robert G Schaub; Thomas W Wakefield
Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation.
Thrombosis and haemostasis 2007;97(3):400-7.
2007: Neelu Kaila; Kristin Janz; Adrian Huang; Alessandro Moretto; Silvano DeBernardo; Patricia W Bedard; Steve Tam; Valerie Clerin; James Carl Keith; Desirée H H Tsao; Natalia Sushkova; Gray D Shaw; Raymond T Camphausen; Robert G Schaub; Qin Wang
2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists.
Journal of medicinal chemistry 2007;50(1):40-64.
2006: Qin Wang; Douglas Shorten; Xin Xu; Gray D Shaw; Robert G Schaub; Christopher Shea; Jonathan Brooks; Dianne Sako; Erin Wiswall; Jin Xu; Pamela Szklut; Vikram S Patel
Effect of von Willebrand factor on the pharmacokinetics of recombinant human platelet glycoprotein Ibalpha-immunoglobulin G1 chimeric proteins.
Pharmaceutical research 2006;23(8):1743-9.
2006: James K Hennan; Robert E Swillo; Gwen A Morgan; Courtney E Leik; Jonathan M Brooks; Gray D Shaw; Robert G Schaub; David L Crandall; George P Vlasuk
Pharmacologic inhibition of platelet vWF-GPIb alpha interaction prevents coronary artery thrombosis.
Thrombosis and haemostasis 2006;95(3):469-75.
2006: Sei-ichiro Tsuchihashi; Constantino Fondevila; Gray D Shaw; Meike Lorenz; Kimberly Marquette; Susan Benard; Xiu-Da Shen; Bibo Ke; Ronald W Busuttil; Jerzy W Kupiec-Weglinski
Molecular characterization of rat leukocyte P-selectin glycoprotein ligand-1 and effect of its blockade: protection from ischemia-reperfusion injury in liver transplantation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):616-24.
2005: Daniel Durant Myers Jr; John E Rectenwald; Patricia W Bedard; Neelu Kaila; Gray D Shaw; Robert G Schaub; Diana M Farris; Angela E Hawley; Shirley K Wrobleski; Peter K Henke; Thomas W Wakefield
Decreased venous thrombosis with an oral inhibitor of P selectin.
Journal of vascular surgery 2005;42(2):329-36.
2005: Martin Gasser; Ana Maria Waaga-Gasser; Michael W Grimm; Martin R Grimm; Miriam S Lenhard; Joana E Kist-Van Holthe; Igor Laskowski; Gray D Shaw; Arnulf Thiede; Wayne W Hancock; Nicholas L Tilney
Selectin blockade plus therapy with low-dose sirolimus and cyclosporin a prevent brain death-induced renal allograft dysfunction.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(4 Pt 1):662-70.
2005: Douglas G Farmer; Xiu-Da Shen; Farin Amersi; Dean M Anselmo; Jeffrey P Ma; Bibo Ke; Feng Gao; Sarah Dry; Susan Fernandez; Gray D Shaw; Sue V McDiarmid; Ronald W Busuttil; Jerzy W Kupiec-Weglinski
CD62 blockade with P-Selectin glycoprotein ligand-immunoglobulin fusion protein reduces ischemia-reperfusion injury after rat intestinal transplantation.
Transplantation 2005;79(1):44-51.
2002: Johann Pratschke; Gregorz Kofla; M Wilhelm; Athanasios Vergopoulos; Igor Laskowski; Gray D Shaw; Stefan G Tullius; Hans-Dieter Volk; P Neuhous; Nicholas L Tilney
Improvements in early behaviour of kidney allografts after donor treatment.
Transplantation proceedings 2002;34(6):2213-4.
2002: Farin Amersi; Douglas G Farmer; Gray D Shaw; Hirohisa Kato; Ana J Coito; Fady Kaldas; Delai Zhao; Charles Lassman; Judy Melinek; Jeffrey Ma; Hans-Dieter Volk; Jerzy W Kupiec-Weglinski; Ronald W Busuttil
P-selectin glycoprotein ligand-1 (rPSGL-Ig)-mediated blockade of CD62 selectin molecules protects rat steatotic liver grafts from ischemia/reperfusion injury.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2002;2(7):600-8.
2002: Ana J Coito; Gray D Shaw; L Meng; Carolina Moore; Jeffrey Ma; Ronald W Busuttil; Jerzy W Kupiec-Weglinski
CD62-PSGL-1 interactions regulate cytokine chemokine and apoptotic networks in cardiac allograft recipients.
Transplantation proceedings 2002;34(5):1463-4.
2002: Martin Gasser; Ana Maria Waaga; Joana E Kist-Van Holthe; Susanne M Lenhard; Igor Laskowski; Gray D Shaw; Wayne W Hancock; Nicholas L Tilney
Normalization of brain death-induced injury to rat renal allografts by recombinant soluble P-selectin glycoprotein ligand.
Journal of the American Society of Nephrology : JASN 2002;13(7):1937-45.
2002: Ana J Coito; Gray D Shaw; Jiye Li; Bibo Ke; Jeffrey Ma; Ronald W Busuttil; Jerzy W Kupiec-Weglinski
Selectin-mediated interactions regulate cytokine networks and macrophage heme oxygenase-1 induction in cardiac allograft recipients.
Laboratory investigation; a journal of technical methods and pathology 2002;82(1):61-70.
2001: Johann Pratschke; Gregorz Kofla; Markus J Wilhelm; Athanasios Vergopoulos; Igor Laskowski; Gray D Shaw; Stefan G Tullius; Hans-Dieter Volk; Peter Neuhaus; Nicholas L Tilney
Improvements in early behavior of rat kidney allografts after treatment of the brain-dead donor.
Annals of surgery 2001;234(6):732-40.
2001: Farin Amersi; TS Dulkanchainun; Sally K Nelson; Douglas G Farmer; Hirohisa Kato; Joseph Zaky; Judy Melinek; Gray D Shaw; Jerzy W Kupiec-Weglinski; Lawrence D Horwitz; Marcus A Horwitz; Ronald W Busuttil
A novel iron chelator in combination with a P-selectin antagonist prevents ischemia/reperfusion injury in a rat liver model.
Transplantation 2001;71(1):112-8.
2000: W S Somers; J Tang; Gray D Shaw; Raymond T Camphausen
Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.
Cell 2000;103(3):467-79.
1999: Mamoru Kusaka; Kambiz Zandi-Nejad; S Kato; Francisca Beato; H Nagano; Gray D Shaw; Nicholas L Tilney
Exploitation of the continuum between early ischemia/reperfusion injury and host alloresponsiveness: indefinite kidney allograft survival by treatment with a soluble P-selectin ligand and low-dose cyclosporine in combination.
Transplantation 1999;67(9):1255-61.
1998: M Takada; KC Nadeau; Wayne W Hancock; Harald S Mackenzie; Gray D Shaw; Ana Maria Waaga; Anil Chandraker; Mohamed H Sayegh; Nicholas L Tilney
Effects of explosive brain death on cytokine activation of peripheral organs in the rat.
Transplantation 1998;65(12):1533-42.
1998: TS Dulkanchainun; John A Goss; David K Imagawa; Gray D Shaw; Dean M Anselmo; Fady Kaldas; T Wang; D Zhao; A A Busuttil; Hirohisa Kato; NG Murray; Jerzy W Kupiec-Weglinski; Ronald W Busuttil
Reduction of hepatic ischemia/reperfusion injury by a soluble P-selectin glycoprotein ligand-1.
Annals of surgery 1998;227(6):832-40.
1998: Mamoru Kusaka; KC Nadeau; M Takada; H Nagano; Gray D Shaw; Nicholas L Tilney
Influence of initial antigen-independent events on acute allograft rejection: inhibition by a soluble P-selectin ligand and low-dose cyclosporine in combination.
Transplantation proceedings 1998;30(4):1027-8.
1997: M Takada; KC Nadeau; Gray D Shaw; Nicholas L Tilney
Prevention of late renal changes after initial ischemia/reperfusion injury by blocking early selectin binding.
Transplantation 1997;64(11):1520-5.
1997: M Takada; KC Nadeau; Gray D Shaw; K A Marquette; Nicholas L Tilney
The cytokine-adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney. Inhibition by a soluble P-selectin ligand.
The Journal of clinical investigation 1997;99(11):2682-90.
1997: M Takada; KC Nadeau; Gray D Shaw; Nicholas L Tilney
Early cellular and molecular changes in ischemia/reperfusion injury: inhibition by a selectin antagonist, P-selectin glycoprotein ligand-1.
Transplantation proceedings 1997;29(1-2):1324-5.