Timothy Blizzard

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Blizzard T A
Selective estrogen receptor modulator medicinal chemistry at Merck. A review.
Blizzard Timothy A; Gude Candido; Morgan Jerry D; Chan Wanda; Birzin Elizabeth T; Mojena Marina; Tudela Consuelo; Chen Fang; Knecht Kristin; Su Qin; Kraker Bryan; Mosley Ralph T; Holmes Mark A; Rohrer Susan P; Hammond Milton L
Androstene-3,5-dienes as ER-beta selective SERMs.
Blizzard Timothy A; Gude Candido; Chan Wanda; Birzin Elizabeth T; Mojena Marina; Tudela Consuelo; Chen Fang; Knecht Kristin; Su Qin; Kraker Bryan; Holmes Mark A; Rohrer Susan P; Hammond Milton L
Bridged androstenediol analogs as ER-beta selective SERMs.

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All Publications

2008: Blizzard T A
Selective estrogen receptor modulator medicinal chemistry at Merck. A review.
Current topics in medicinal chemistry 2008;8(9):792-812.
2007: Blizzard Timothy A; Gude Candido; Morgan Jerry D; Chan Wanda; Birzin Elizabeth T; Mojena Marina; Tudela Consuelo; Chen Fang; Knecht Kristin; Su Qin; Kraker Bryan; Mosley Ralph T; Holmes Mark A; Rohrer Susan P; Hammond Milton L
Androstene-3,5-dienes as ER-beta selective SERMs.
Bioorganic & medicinal chemistry letters 2007;17(22):6295-8.
2007: Blizzard Timothy A; Gude Candido; Chan Wanda; Birzin Elizabeth T; Mojena Marina; Tudela Consuelo; Chen Fang; Knecht Kristin; Su Qin; Kraker Bryan; Holmes Mark A; Rohrer Susan P; Hammond Milton L
Bridged androstenediol analogs as ER-beta selective SERMs.
Bioorganic & medicinal chemistry letters 2007;17(10):2944-8.
2006: Blizzard Timothy A; Gude Candido; Morgan Jerry D; Chan Wanda; Birzin Elizabeth T; Mojena Marina; Tudela Consuelo; Chen Fang; Knecht Kristin; Su Qin; Kraker Bryan; Mosley Ralph T; Holmes Mark A; Sharma Nandini; Fitzgerald Paula M D; Rohrer Susan P; Hammond Milton L
Androstenediol analogs as ER-beta-selective SERMs.
Bioorganic & medicinal chemistry letters 2006;16(4):834-8.
2005: Blizzard Timothy A; Morgan Jerry D; Chan Wanda; Birzin Elizabeth T; Pai Lee-Yuh; Hayes Edward C; DaSilva Carolyn A; Mosley Ralph T; Yang Yi Tien; Rohrer Susan P; Dininno Frank; Hammond Milton L
Estrogen receptor ligands. Part 14: application of novel antagonist side chains to existing platforms.
Bioorganic & medicinal chemistry letters 2005;15(23):5124-8.
2005: Blizzard Timothy A; DiNinno Frank; Chen Helen Y; Kim Seongkon; Wu Jane Y; Chan Wanda; Birzin Elizabeth T; Yang Yi Tien; Pai Lee-Yuh; Hayes Edward C; DaSilva Carolyn A; Rohrer Susan P; Schaeffer James M; Hammond Milton L
Estrogen receptor ligands. Part 13: Dihydrobenzoxathiin SERAMs with an optimized antagonist side chain.
Bioorganic & medicinal chemistry letters 2005;15(17):3912-6.
2005: Tan Qiang; Blizzard Timothy A; Morgan Jerry D; Birzin Elizabeth T; Chan Wanda; Yang Yi Tien; Pai Lee-Yuh; Hayes Edward C; DaSilva Carolyn A; Warrier Sudha; Yudkovitz Joel; Wilkinson Hilary A; Sharma Nandini; Fitzgerald Paula M D; Li Susan; Colwell Lawrence; Fisher John E; Adamski Sharon; Reszka Alfred A; Kimmel Donald; DiNinno Frank; Rohrer Susan P; Freedman Leonard P; Schaeffer James M; Hammond Milton L
Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.
Bioorganic & medicinal chemistry letters 2005;15(6):1675-81.
2005: Blizzard Timothy A; Dininno Frank; Morgan Jerry D; Chen Helen Y; Wu Jane Y; Kim Seongkon; Chan Wanda; Birzin Elizabeth T; Yang Yi Tien; Pai Lee-Yuh; Fitzgerald Paula M D; Sharma Nandini; Li Ying; Zhang Zhoupeng; Hayes Edward C; Dasilva Carolyn A; Tang Wei; Rohrer Susan P; Schaeffer James M; Hammond Milton L
Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
Bioorganic & medicinal chemistry letters 2005;15(1):107-13.
2004: Blizzard Timothy A; DiNinno Frank; Morgan Jerry D; Wu Jane Y; Chen Helen Y; Kim Seongkon; Chan Wanda; Birzin Elizabeth T; Yang Yi Tien; Pai Lee-Yuh; Zhang Zhoupeng; Hayes Edward C; DaSilva Carolyn A; Tang Wei; Rohrer Susan P; Schaeffer James M; Hammond Milton L
Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains.
Bioorganic & medicinal chemistry letters 2004;14(15):3865-8.
2004: Blizzard Timothy A; DiNinno Frank; Morgan Jerry D; Chen Helen Y; Wu Jane Y; Gude Candido; Kim Seongkon; Chan Wanda; Birzin Elizabeth T; Tien Yang Yi; Pai Lee-Yuh; Zhang Zhoupeng; Hayes Edward C; DaSilva Carolyn A; Tang Wei; Rohrer Susan P; Schaeffer James M; Hammond Milton L
Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains.
Bioorganic & medicinal chemistry letters 2004;14(15):3861-4.
2004: Blizzard Timothy A; Mosley Ralph T; Birzin Elizabeth T; Chan Wanda; Hammond Milton L
Comparison of 2-phenylspiroindenes and 2-phenylspiroindenediones as estrogen receptor ligands--modeling and binding data don't agree!
Bioorganic & medicinal chemistry letters 2004;14(5):1317-21.
2003: Peekhaus Norbert T; Ferrer Marc; Chang Tina; Kornienko Oleg; Schneeweis Jonathan E; Smith Todd S; Hoffman Ira; Mitnaul Lyndon J; Chin Jayne; Fischer Paul A; Blizzard Tim A; Birzin Elizabeth T; Chan Wanda; Inglese James; Strulovici Berta; Rohrer Susan P; Schaeffer James M
A beta-lactamase-dependent Gal4-estrogen receptor beta transactivation assay for the ultra-high throughput screening of estrogen receptor beta agonists in a 3456-well format.
Assay and drug development technologies 2003;1(6):789-800.
2003: Blizzard Timothy A; Morgan Jerry D; Mosley Ralph T; Birzin Elizabeth T; Frisch Katalin; Rohrer Susan P; Hammond Milton L
2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs).
Bioorganic & medicinal chemistry letters 2003;13(3):479-83.
2002: Chen Qing; Ngui Jason S; Doss George A; Wang Regina W; Cai Xiaoxin; DiNinno Frank P; Blizzard Timothy A; Hammond Milton L; Stearns Ralph A; Evans David C; Baillie Thomas A; Tang Wei
Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.
Chemical research in toxicology 2002;15(7):907-14.
2002: Blizzard Timothy A; Kim Ronald M; Morgan Jerry D; Chang Jiang; Kohler Joyce; Kilburn Ruth; Chapman Kevin; Hammond Milton L
Antibacterial activity of G6-quaternary ammonium derivatives of a lipophilic vancomycin analogue.
Bioorganic & medicinal chemistry letters 2002;12(6):849-52.
1999: Ratcliffe R W; Wilkening R R; Wildonger K J; Waddell S T; Santorelli G M; Parker D L; Morgan J D; Blizzard T A; Hammond M L; Heck J V; Huber J; Kohler J; Dorso K L; St Rose E; Sundelof J G; May W J; Hammond G G
Synthesis and properties of 2-(naphthosultamyl)methyl-carbapenems with potent anti-MRSA activity: discovery of L-786,392.
Bioorganic & medicinal chemistry letters 1999;9(5):679-84.
1999: Wilkening R R; Ratcliffe R W; Wildonger K J; Cama L D; Dykstra K D; DiNinno F P; Blizzard T A; Hammond M L; Heck J V; Dorso K L; St Rose E; Kohler J; Hammond G G
Synthesis and activity of 2-(sulfonamido)methyl-carbapenems: discovery of a novel, anti-MRSA 1,8-naphthosultam pharmacophore.
Bioorganic & medicinal chemistry letters 1999;9(5):673-8.
1999: Rosen H; Hajdu R; Silver L; Kropp H; Dorso K; Kohler J; Sundelof J G; Huber J; Hammond G G; Jackson J J; Gill C J; Thompson R; Pelak B A; Epstein-Toney J H; Lankas G; Wilkening R R; Wildonger K J; Blizzard T A; DiNinno F P; Ratcliffe R W; Heck J V; Kozarich J W; Hammond M L
Reduced immunotoxicity and preservation of antibacterial activity in a releasable side-chain carbapenem antibiotic.
Science (New York, N.Y.) 1999;283(5402):703-6.
1998: Waddell S T; Santorelli G M; Blizzard T A; Graham A; Occi J
Synthesis and antibacterial activity of O-methyl derivatives of azalide antibiotics: II. 6-OME derivatives via clarithromycin.
Bioorganic & medicinal chemistry letters 1998;8(11):1321-6.
1998: Waddell S T; Santorelli G M; Blizzard T A; Graham A; Occi J
Synthesis and antibacterial activity of O-methyl derivatives of azalide antibiotics: I. 4", 11 and 12-OMe derivatives via direct methylation.
Bioorganic & medicinal chemistry letters 1998;8(5):549-54.

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Timothy Blizzard

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