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James Shayman

Research Profile

Living Beings

Mouse

Chemicals & Drugs

Disorders

Fabry's Disease

Anatomy

Physiology

Phagocytosis

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Publications

TOP 3
Julian R Arthur; Scott D Larsen; Hannah E Rockwell; James A Shayman; Michael W Wilson; Thomas N Seyfried
Ethylenedioxy-PIP2 oxalate reduces ganglioside storage in juvenile Sandhoff disease mice.
Crina Paduraru; James A Shayman; Natacha Veerapen; Robert Kelly; Amit Kunte; Gurdyal S Besra; Jelena S Bezbradica; Liam R Cox; Peter Cresswell
Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition.
Akira Abe; Piotr W Rzepecki; James A Shayman
A fluorogenic phospholipid for the detection of lysosomal phospholipase A2 activity.

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All Publications

2013: Julian R Arthur; Scott D Larsen; Hannah E Rockwell; James A Shayman; Michael W Wilson; Thomas N Seyfried
Ethylenedioxy-PIP2 oxalate reduces ganglioside storage in juvenile Sandhoff disease mice.
Neurochemical research 2013;38(4):866-75.
2013: Crina Paduraru; James A Shayman; Natacha Veerapen; Robert Kelly; Amit Kunte; Gurdyal S Besra; Jelena S Bezbradica; Liam R Cox; Peter Cresswell
Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(13):5097-102.
2013: Akira Abe; Piotr W Rzepecki; James A Shayman
A fluorogenic phospholipid for the detection of lysosomal phospholipase A2 activity.
Analytical biochemistry 2013;434(1):78-83.
2013: James A Shayman; Akira Abe
Drug induced phospholipidosis: an acquired lysosomal storage disorder.
Biochimica et biophysica acta 2013;1831(3):602-11.
2012: Seung-Yeol Park; James A Shayman; Chan-Yeong Kwak; Jung Hoe Kim
Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor.
Biochimica et biophysica acta 2012;1820(7):1141-8.
2012: Scott D Larsen; Michael W Wilson; Christopher H George; Liming Shu; H D Hollis Showalter; Paul Kirchhoff; Richard F Keep; Akira Abe; Jianming Xiang; James A Shayman
Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain.
Journal of lipid research 2012;53(2):282-91.
2011: Yunxiang Zhu; Nathan Gumlaw; Jozsef Karman; Hongmei Zhao; Jinhua Zhang; Ji-Lei Jiang; Pete Maniatis; Andrea Edling; Wei-Lien Chuang; Craig Siegel; James A Shayman; Johanne Kaplan; Canwen Jiang; Seng H Cheng
Lowering glycosphingolipid levels in CD4+ T cells attenuates T cell receptor signaling, cytokine production, and differentiation to the Th17 lineage.
The Journal of biological chemistry 2011;286(17):14787-94.
2011: James A Shayman; Robert Kelly; Jessica Kollmeyer; Yongqun He; Akira Abe
Group XV phospholipase A₂, a lysosomal phospholipase A₂.
Progress in lipid research 2011;50(1):1-13.
2010: Akira Abe; Robert Kelly; James A Shayman
The measurement of lysosomal phospholipase A2 activity in plasma.
Journal of lipid research 2010;51(8):2464-70.
2010: Thomas A Natoli; Laurie A Smith; Kelly A Rogers; Bing Wang; Svetlana Komarnitsky; Yeva Budman; Alexei Belenky; Nikolay O Bukanov; William R Dackowski; Hervé Husson; Ryan J Russo; James A Shayman; Steven R Ledbetter; John P Leonard; Oxana Ibraghimov-Beskrovnaya
Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models.
Nature medicine 2010;16(7):788-92.
2010: John Marshall; Kerry Anne McEachern; Wei-Lien Chuang; Elizabeth Hutto; Craig S Siegel; James A Shayman; Greg A Grabowski; Ronald K Scheule; Diane P Copeland; Seng Cheng
Improved management of lysosomal glucosylceramide levels in a mouse model of type 1 Gaucher disease using enzyme and substrate reduction therapy.
Journal of inherited metabolic disease 2010;33(3):281-9.
2010: James A Shayman
The riddle of the sphinx redux.
Kidney international 2010;77(10):843-5.
2010: John Marshall; Karen M Ashe; Dinesh Bangari; KerryAnne McEachern; Wei-Lien Chuang; Joshua Pacheco; Diane P Copeland; Robert J Desnick; James A Shayman; Ronald K Scheule; Seng Cheng
Substrate reduction augments the efficacy of enzyme therapy in a mouse model of Fabry disease.
PloS one 2010;5(11):e15033.
2010: Vania Hinkovska-Galcheva; James A Shayman
Ceramide-1-phosphate in phagocytosis and calcium homeostasis.
Advances in experimental medicine and biology 2010;688():131-40.
2010: Nelson S Yew; Hongmei Zhao; Eun-Gyoung Hong; I-Huan Wu; Malgorzata Przybylska; Craig Siegel; James A Shayman; Cynthia M Arbeeny; Jason K Kim; Canwen Jiang; Seng Cheng
Increased hepatic insulin action in diet-induced obese mice following inhibition of glucosylceramide synthase.
PloS one 2010;5(6):e11239.
2009: Akira Abe; James A Shayman
The role of negatively charged lipids in lysosomal phospholipase A2 function.
Journal of lipid research 2009;50(10):2027-35.
2009: Liming Shu; James L Park; Jaeman Byun; Subramaniam Pennathur; Jessica Kollmeyer; James A Shayman
Decreased nitric oxide bioavailability in a mouse model of Fabry disease.
Journal of the American Society of Nephrology : JASN 2009;20(9):1975-85.
2009: Hongmei Zhao; Malgorzata Przybylska; I-Huan Wu; Jinhua Zhang; Panagiotis Maniatis; Joshua Pacheco; Peter Piepenhagen; Diane Copeland; Cynthia Arbeeny; James A Shayman; Johannes M Aerts; Canwen Jiang; Seng Cheng; Nelson S Yew
Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice.
Hepatology (Baltimore, Md.) 2009;50(1):85-93.
2009: Stefan Taube; Jeffrey W Perry; Kristen Yetming; Sagar P Patel; Heather Auble; Liming Shu; Hesham F Nawar; Chang Hoon Lee; Terry D Connell; James A Shayman; Christiane E Wobus
Ganglioside-linked terminal sialic acid moieties on murine macrophages function as attachment receptors for murine noroviruses.
Journal of virology 2009;83(9):4092-101.
2009: James L Park; Liming Shu; James A Shayman
Differential involvement of COX1 and COX2 in the vasculopathy associated with the alpha-galactosidase A-knockout mouse.
American journal of physiology. Heart and circulatory physiology 2009;296(4):H1133-40.
2009: luigi franchi; Grace Chen; Noemi Marina-Garcia; Akira Abe; Yan Qu; Shunzhong Bao; James A Shayman; John Turk; George R Dubyak; Gabriel Núñez
Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone.
Journal of innate immunity 2009;1(6):607-17.
2008: Akira Abe; Robert Kelly; Jessica Kollmeyer; Miki Hiraoka; Ye Lu; James A Shayman
The secretion and uptake of lysosomal phospholipase A2 by alveolar macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):7873-81.
2008: Jin-Song Shen; Xing-Li Meng; David F Moore; Jane M Quirk; James A Shayman; Raphael Schiffmann; Christine R Kaneski
Globotriaosylceramide induces oxidative stress and up-regulates cell adhesion molecule expression in Fabry disease endothelial cells.
Molecular genetics and metabolism 2008;95(3):163-8.
2008: James L Park; Steven E Whitesall; Louis G D'Alecy; Liming Shu; James A Shayman
Vascular dysfunction in the alpha-galactosidase A-knockout mouse is an endothelial cell-, plasma membrane-based defect.
Clinical and experimental pharmacology & physiology 2008;35(10):1156-63.
2008: Elias N Glaros; Woojin S Kim; Kerry-Anne Rye; James A Shayman; Brett Garner
Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice.
Journal of lipid research 2008;49(8):1677-81.
2008: Vania Hinkovska-Galcheva; Andrea Clark; Susan VanWay; Ji-Biao Huang; Miki Hiraoka; Akira Abe; Michael Borofsky; Robin G Kunkel; Thomas P Shanley; James A Shayman; Frederick Lanni; Howard R Petty; Laurence A Boxer
Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells.
Journal of lipid research 2008;49(3):531-42.
2008: Susann Patschan; Jun Chen; Olga Gealekman; Katrina Krupincza; Maureen Wang; Liming Shu; James A Shayman; Michael S Goligorsky
Mapping mechanisms and charting the time course of premature cell senescence and apoptosis: lysosomal dysfunction and ganglioside accumulation in endothelial cells.
American journal of physiology. Renal physiology 2008;294(1):F100-9.
2007: Akira Abe; Miki Hiraoka; James A Shayman
The acylation of lipophilic alcohols by lysosomal phospholipase A2.
Journal of lipid research 2007;48(10):2255-63.
2007: Liming Shu; James A Shayman
Caveolin-associated accumulation of globotriaosylceramide in the vascular endothelium of alpha-galactosidase A null mice.
The Journal of biological chemistry 2007;282(29):20960-7.
2007: Kerry Anne McEachern; John Fung; Svetlana Komarnitsky; Craig S Siegel; Wei-Lien Chuang; Elizabeth Hutto; James A Shayman; Gregory A Grabowski; johannes aerts; Seng Cheng; Diane P Copeland; John Marshall
A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease.
Molecular genetics and metabolism 2007;91(3):259-67.
2007: Peter F Bodary; James A Shayman; Daniel T Eitzman
Alpha-galactosidase A in vascular disease.
Trends in cardiovascular medicine 2007;17(4):129-33.
2007: Akira Abe; Miki Hiraoka; James A Shayman
A role for lysosomal phospholipase A2 in drug induced phospholipidosis.
Drug metabolism letters 2007;1(1):49-53.
2006: Akira Abe; Miki Hiraoka; James A Shayman
Positional specificity of lysosomal phospholipase A2.
Journal of lipid research 2006;47(10):2268-79.
2006: Miki Hiraoka; Akira Abe; Ye Lu; Kui Yang; Xianlin Han; Richard W Gross; James A Shayman
Lysosomal phospholipase A2 and phospholipidosis.
Molecular and cellular biology 2006;26(16):6139-48.
2006: Yuechun Shen; Peter F Bodary; Fernando B Vargas; Jonathon W Homeister; David F Gordon; Kristen A Ostenso; James A Shayman; Daniel T Eitzman
Alpha-galactosidase A deficiency leads to increased tissue fibrin deposition and thrombosis in mice homozygous for the factor V Leiden mutation.
Stroke; a journal of cerebral circulation 2006;37(4):1106-8.
2006: Xiujun Pi; Shi-Yu Tan; Michael Hayes; Liqun Xiao; James A Shayman; Song Ling; Joseph Holoshitz
Sphingosine kinase 1-mediated inhibition of Fas death signaling in rheumatoid arthritis B lymphoblastoid cells.
Arthritis and rheumatism 2006;54(3):754-64.
2006: James A Shayman
Thinking about rare kidney diseases.
Journal of the American Society of Nephrology : JASN 2006;17(1):15-6.
2005: Miki Hiraoka; Akira Abe; James A Shayman
Structure and function of lysosomal phospholipase A2: identification of the catalytic triad and the role of cysteine residues.
Journal of lipid research 2005;46(11):2441-7.
2005: Liming Shu; Hedwig S Murphy; Laura Cooling; James A Shayman
An in vitro model of Fabry disease.
Journal of the American Society of Nephrology : JASN 2005;16(9):2636-45.
2005: Vania Hinkovska-Galcheva; Laurence A Boxer; Andrei L Kindzelskii; Miki Hiraoka; Akira Abe; Sravan Goparju; Sarah Spiegel; Howard R Petty; James A Shayman
Ceramide 1-phosphate, a mediator of phagocytosis.
The Journal of biological chemistry 2005;280(28):26612-21.
2005: Pamela J Mansfield; Vania Hinkovska-Galcheva; Michael S Borofsky; James A Shayman; Laurence A Boxer
Phagocytic signaling molecules in lipid rafts of COS-1 cells transfected with FcgammaRIIA.
Biochemical and biophysical research communications 2005;331(1):132-8.
2005: Peter F Bodary; Yuechun Shen; Fernando B Vargas; Xiaoming Bi; Kristen A Ostenso; Shufang Gu; James A Shayman; Daniel T Eitzman
Alpha-galactosidase A deficiency accelerates atherosclerosis in mice with apolipoprotein E deficiency.
Circulation 2005;111(5):629-32.
2004: Akira Abe; Miki Hiraoka; Susan R Wild; Steven E Wilcoxen; Robert Paine; James A Shayman
Lysosomal phospholipase A2 is selectively expressed in alveolar macrophages.
The Journal of biological chemistry 2004;279(41):42605-11.
2004: Akira Abe; Heather K Poucher; Miki Hiraoka; James A Shayman
Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells.
Journal of lipid research 2004;45(4):667-73.
2004: Pamela J Mansfield; Shannon S Carey; Vania Hinkovska-Galcheva; James A Shayman; Laurence A Boxer
Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTP gamma S-stimulated polymorphonuclear leukocytes.
Blood 2004;103(6):2363-8.
2004: James A Shayman; Akira Abe; Miki Hiraoka
A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide transacylase activity.
Glycoconjugate journal 2004;20(1):25-32.
2003: Liming Shu; James A Shayman
Src kinase mediates the regulation of phospholipase C-gamma activity by glycosphingolipids.
The Journal of biological chemistry 2003;278(33):31419-25.
2003: Daniel T Eitzman; Peter F Bodary; Yuechun Shen; Christian G Khairallah; Susan R Wild; Akira Abe; Jacqueline Shaffer-Hartman; James A Shayman
Fabry disease in mice is associated with age-dependent susceptibility to vascular thrombosis.
Journal of the American Society of Nephrology : JASN 2003;14(2):298-302.
2003: Vania Hinkovska-Galcheva; Laurence A Boxer; Pamela J Mansfield; Alan D Schreiber; James A Shayman
Enhanced phagocytosis through inhibition of de novo ceramide synthesis.
The Journal of biological chemistry 2003;278(2):974-82.
2002: Steven B Levery; Michelle Momany; Rebecca Lindsey; Marcos Toledo; James A Shayman; Matthew Fuller; Kelly Brooks; Ron Lou Doong; Anita H Straus; Helio K Takahashi
Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP-Glc:ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth.
FEBS letters 2002;525(1-3):59-64.
2002: Pamela J Mansfield; Vania Hinkovska-Galcheva; James A Shayman; Laurence A Boxer
Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release.
The Journal of laboratory and clinical medicine 2002;140(1):9-16.
2002: Liming Shu; Lihsueh Lee; James A Shayman
Regulation of phospholipase C-gamma activity by glycosphingolipids.
The Journal of biological chemistry 2002;277(21):18447-53.
2002: Miki Hiraoka; Akira Abe; James A Shayman
Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase.
The Journal of biological chemistry 2002;277(12):10090-9.
2002: Pamela J Mansfield; Vania Hinkovska-Galcheva; Shannon S Carey; James A Shayman; Laurence A Boxer
Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D.
Blood 2002;99(4):1434-41.
2001: Akira Abe; Susan R Wild; W L Lee; James A Shayman
Agents for the treatment of glycosphingolipid storage disorders.
Current drug metabolism 2001;2(3):331-8.
2001: Hubert Zajicek; H Wang; Krishna Puttaparthi; Nabil Halaihel; Daniel Markovich; James A Shayman; R Béliveau; P Wilson; Thomas Rogers; Marcel Levi
Glycosphingolipids modulate renal phosphate transport in potassium deficiency.
Kidney international 2001;60(2):694-704.
2001: David A Fox; X He; Akira Abe; T Hollander; L L Li; Li Kan; A W Friedman; Yoji Shimizu; James A Shayman; K Kozarsky
The T lymphocyte structure CD60 contains a sialylated carbohydrate epitope that is expressed on both gangliosides and glycoproteins.
Immunological investigations 2001;30(2):67-85.
2001: Stephen Cooper; James A Shayman
Revisiting retinoblastoma protein phosphorylation during the mammalian cell cycle.
Cellular and molecular life sciences : CMLS 2001;58(4):580-95.
2000: Akira Abe; S Gregory; Lihsueh Lee; James A Shayman
Use of sulfobutyl ether beta-cyclodextrin as a vehicle for D-threo-1-phenyl-2-decanoylamino-3-morpholinopropanol-relat ed glucosylceramide synthase inhibitors.
Analytical biochemistry 2000;287(2):344-7.
2000: James A Shayman
Sphingolipids.
Kidney international 2000;58(1):11-26.
2000: Akira Abe; S Gregory; Lihsueh Lee; Paul D Killen; R O Brady; A Kulkarni; James A Shayman
Reduction of globotriaosylceramide in Fabry disease mice by substrate deprivation.
The Journal of clinical investigation 2000;105(11):1563-71.
2000: Pamela J Mansfield; James A Shayman; Laurence A Boxer
Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase.
Blood 2000;95(7):2407-12.
2000: Akira Abe; Lois J Arend; Lihsueh Lee; C Lingwood; R O Brady; James A Shayman
Glycosphingolipid depletion in fabry disease lymphoblasts with potent inhibitors of glucosylceramide synthase.
Kidney international 2000;57(2):446-54.
2000: Liming Shu; Lihsueh Lee; Y Chang; Lawrence B Holzman; C A Edwards; Eric A Shelden; James A Shayman
Caveolar structure and protein sorting are maintained in NIH 3T3 cells independent of glycosphingolipid depletion.
Archives of biochemistry and biophysics 2000;373(1):83-90.
2000: James A Shayman; Lihsueh Lee; Akira Abe; Liming Shu
Inhibitors of glucosylceramide synthase.
Methods in enzymology 2000;311():373-87.
2000: James A Shayman; Akira Abe
1-O-acylceramide synthase.
Methods in enzymology 2000;311():105-17.
2000: James A Shayman; Akira Abe
Glucosylceramide synthase: assay and properties.
Methods in enzymology 2000;311():42-9.
1999: E M Raeder; Pamela J Mansfield; Vania Hinkovska-Galcheva; James A Shayman; Laurence A Boxer
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6785-93.
1999: Stephen Cooper; C Yu; James A Shayman
Phosphorylation-dephosphorylation of retinoblastoma protein not necessary for passage through the mammalian cell division cycle.
IUBMB life 1999;48(2):225-30.
1999: Lihsueh Lee; Akira Abe; James A Shayman
Improved inhibitors of glucosylceramide synthase.
The Journal of biological chemistry 1999;274(21):14662-9.
1999: E M Raeder; Pamela J Mansfield; Vania Hinkovska-Galcheva; L Kjeldsen; James A Shayman; Laurence A Boxer
Sphingosine blocks human polymorphonuclear leukocyte phagocytosis through inhibition of mitogen-activated protein kinase activation.
Blood 1999;93(2):686-93.
1998: Vania Hinkovska-Galcheva; Laurence A Boxer; Pamela J Mansfield; Donna M Harsh; R Alexander Blackwood; James A Shayman
The formation of ceramide-1-phosphate during neutrophil phagocytosis and its role in liposome fusion.
The Journal of biological chemistry 1998;273(50):33203-9.
1998: Vania Hinkovska-Galcheva; L Kjeldsen; Pamela J Mansfield; Laurence A Boxer; James A Shayman; SJ Suchard
Activation of a plasma membrane-associated neutral sphingomyelinase and concomitant ceramide accumulation during IgG-dependent phagocytosis in human polymorphonuclear leukocytes.
Blood 1998;91(12):4761-9.
1998: Akira Abe; James A Shayman
Purification and characterization of 1-O-acylceramide synthase, a novel phospholipase A2 with transacylase activity.
The Journal of biological chemistry 1998;273(14):8467-74.
1998: James A Shayman
Establishing a role for sphingolipids in renal injury and stress responses.
Kidney international 1998;53(3):790-1.
1998: Y Takami; Akira Abe; T Matsuda; James A Shayman; N S Radin; robert walter
Effect of an inhibitor of glucosylceramide synthesis on cultured human keratinocytes.
The Journal of dermatology 1998;25(2):73-7.
1997: SJ Suchard; Pamela J Mansfield; Laurence A Boxer; James A Shayman
Mitogen-activated protein kinase activation during IgG-dependent phagocytosis in human neutrophils: inhibition by ceramide.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4961-7.
1997: SJ Suchard; Vania Hinkovska-Galcheva; Pamela J Mansfield; Laurence A Boxer; James A Shayman
Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes.
Blood 1997;89(6):2139-47.
1997: Alfred H Merrill; Eva M. Schmelz; Dirck L Dillehay; S Spiegel; James A Shayman; J J Schroeder; Ronald T Riley; Kenneth A Voss; Elaine Wang
Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology.
Toxicology and applied pharmacology 1997;142(1):208-25.
1996: Akira Abe; James A Shayman; N S Radin
A novel enzyme that catalyzes the esterification of N-acetylsphingosine. Metabolism of C2-ceramides.
The Journal of biological chemistry 1996;271(24):14383-9.
1996: Alicja Bielawska; M S Greenberg; D Perry; S Jayadev; James A Shayman; C McKay; Yusuf A Hannun
(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase.
The Journal of biological chemistry 1996;271(21):12646-54.
1996: M el-Khatib; N S Radin; James A Shayman
Glycosphingolipid synthesis and proliferation in a renal cell line grown in high glucose.
The American journal of physiology 1996;270(3 Pt 2):F476-84.
1996: Akira Abe; N S Radin; James A Shayman
Induction of glucosylceramide synthase by synthase inhibitors and ceramide.
Biochimica et biophysica acta 1996;1299(3):333-41.
1996: James A Shayman
Sphingolipids: their role in intracellular signaling and renal growth.
Journal of the American Society of Nephrology : JASN 1996;7(2):171-82.
1995: Y Chang; Akira Abe; James A Shayman
Ceramide formation during heat shock: a potential mediator of alpha B-crystallin transcription.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12275-9.
1995: Marcel Levi; James A Shayman; Akira Abe; S K Gross; R H McCluer; Jürg Biber; Heini Murer; Marius Lötscher; R E Cronin
Dexamethasone modulates rat renal brush border membrane phosphate transporter mRNA and protein abundance and glycosphingolipid composition.
The Journal of clinical investigation 1995;96(1):207-16.
1995: Marja Jäättelä; M Benedict; M Tewari; James A Shayman; V M Dixit
Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.
Oncogene 1995;10(12):2297-305.
1995: Akira Abe; N S Radin; James A Shayman; LL Wotring; R E Zipkin; R Sivakumar; J M Ruggieri; K G Carson; B Ganem
Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth.
Journal of lipid research 1995;36(3):611-21.
1995: C S Rani; Akira Abe; Y Chang; N Rosenzweig; Alan Saltiel; N S Radin; James A Shayman
Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases.
The Journal of biological chemistry 1995;270(6):2859-67.
1994: G D Deshmukh; N S Radin; V H Gattone; James A Shayman
Abnormalities of glycosphingolipid, sulfatide, and ceramide in the polycystic (cpk/cpk) mouse.
Journal of lipid research 1994;35(9):1611-8.
1994: T Nakamura; SJ Suchard; Akira Abe; James A Shayman; Laurence A Boxer
Role of diradylglycerol formation in H2O2 and lactoferrin release in adherent human polymorphonuclear leukocytes.
Journal of leukocyte biology 1994;56(2):105-9.
1994: T Nakamura; Akira Abe; K J Balazovich; D Wu; SJ Suchard; Laurence A Boxer; James A Shayman
Ceramide regulates oxidant release in adherent human neutrophils.
The Journal of biological chemistry 1994;269(28):18384-9.
1994: J C Betts; A B Agranoff; Gary Nabel; James A Shayman
Dissociation of endogenous cellular ceramide from NF-kappa B activation.
The Journal of biological chemistry 1994;269(11):8455-8.
1994: SJ Suchard; T Nakamura; Akira Abe; James A Shayman; Laurence A Boxer
Phospholipase D-mediated diradylglycerol formation coincides with H2O2 and lactoferrin release in adherent human neutrophils.
The Journal of biological chemistry 1994;269(11):8063-8.
1993: David I Yule; D Wu; T E Essington; James A Shayman; John Williams
Sphingosine metabolism induces Ca2+ oscillations in rat pancreatic acinar cells.
The Journal of biological chemistry 1993;268(17):12353-8.
1993: I Z Zador; G D Deshmukh; R Kunkel; K Johnson; N S Radin; James A Shayman
A role for glycosphingolipid accumulation in the renal hypertrophy of streptozotocin-induced diabetes mellitus.
The Journal of clinical investigation 1993;91(3):797-803.
1993: N S Radin; James A Shayman; J Inokuchi
Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances.
Advances in lipid research 1993;26():183-213.
1992: Akira Abe; D Wu; James A Shayman; N S Radin
Metabolic effects of short-chain ceramide and glucosylceramide on sphingolipids and protein kinase C.
European journal of biochemistry / FEBS 1992;210(3):765-73.
1992: Akira Abe; James A Shayman; N S Radin
Fluorescence assay of glucosylceramide glucosidase using NBD-cerebroside.
Lipids 1992;27(12):1052-4.
1992: Hedwig S Murphy; James A Shayman; Gerd O Till; M Mahrougui; C B Owens; U S Ryan; Peter A Ward
Superoxide responses of endothelial cells to C5a and TNF-alpha: divergent signal transduction pathways.
The American journal of physiology 1992;263(1 Pt 1):L51-9.
1992: Atul Sahai; R S Sandler; G Xu; James A Shayman; R L Tannen
Signal transduction events whereby PGF2 alpha inhibits the ammoniagenic response to acute acidosis.
The American journal of physiology 1992;262(6 Pt 2):F950-6.
1992: L Greenberg; A Q Urbanes; James A Shayman
Unimpaired formation of hormone-stimulated inositol trisphosphate in human mesangial cells under hyperglycemic conditions.
Biochimica et biophysica acta 1992;1138(3):229-35.
1992: S Mahdiyoun; G D Deshmukh; Akira Abe; N S Radin; James A Shayman
Decreased formation of inositol trisphosphate in Madin-Darby canine kidney cells under conditions of beta-glucosidase inhibition.
Archives of biochemistry and biophysics 1992;292(2):506-11.
1992: Akira Abe; J Inokuchi; M Jimbo; Hiroshi Shimeno; A Nagamatsu; James A Shayman; G S Shukla; N S Radin
Improved inhibitors of glucosylceramide synthase.
Journal of biochemistry 1992;111(2):191-6.
1991: James A Shayman; G D Deshmukh; S Mahdiyoun; Thommey P Thomas; D Wu; F S Barcelon; N S Radin
Modulation of renal epithelial cell growth by glucosylceramide. Association with protein kinase C, sphingosine, and diacylglycerol.
The Journal of biological chemistry 1991;266(34):22968-74.
1991: James A Shayman; N S Radin
Structure and function of renal glycosphingolipids.
The American journal of physiology 1991;260(3 Pt 2):F291-302.
1990: James A Shayman; S Mahdiyoun; G Deshmukh; F Barcelon; J Inokuchi; N S Radin
Glucosphingolipid dependence of hormone-stimulated inositol trisphosphate formation.
The Journal of biological chemistry 1990;265(21):12135-8.
1990: James A Shayman; F S Barcelon
Ion-pair chromatography of inositol polyphosphates with N-methylimipramine.
Journal of chromatography 1990;528(1):143-54.
1990: C Galvao; James A Shayman
The phosphatidylinositol synthase of proximal tubule cells.
Biochimica et biophysica acta 1990;1044(1):34-42.
1990: James A Shayman; D Wu
Myo-inositol does not modulate PI turnover in MDCK cells under hyperosmolar conditions.
The American journal of physiology 1990;258(5 Pt 2):F1282-7.
1989: Joel M Weinberg; J A Davis; James A Shayman; P R Knight
Alterations of cytosolic calcium in LLC-PK1 cells induced by vasopressin and exogenous purines.
The American journal of physiology 1989;256(5 Pt 1):C967-76.
1988: James A Shayman; D M BeMent
The separation of myo-inositol phosphates by ion-pair chromatography.
Biochemical and biophysical research communications 1988;151(1):114-22.
1987: James A Shayman; J J Morrissey; A R Morrison
Islet activating protein inhibits kinin-stimulated inositol phosphate production, calcium mobilization, and prostaglandin E2 synthesis in renal papillary collecting tubule cells independent of cyclic AMP.
The Journal of biological chemistry 1987;262(35):17083-7.
1987: James A Shayman; M T Kirkwood
Bradykinin-stimulated changes in inositol phosphate mass in renal papillary collecting tubule cells.
Biochemical and biophysical research communications 1987;145(3):1119-25.
1987: D Portilla; James A Shayman; A R Morrison
Vasopressin does not hydrolyze polyphosphoinositides in rabbit papillary collecting tubule cells.
Biochimica et biophysica acta 1987;928(3):305-11.
1987: James A Shayman; A R Morrison; O H Lowry
Enzymatic fluorometric assay for myo-inositol trisphosphate.
Analytical biochemistry 1987;162(2):562-8.
1986: James A Shayman; R J Auchus; A R Morrison
Bradykinin-induced changes in myo-inositol 1,2-(cyclic)phosphate in rabbit papillary collecting tubule cells.
Biochimica et biophysica acta 1986;888(2):171-5.
1986: James A Shayman; Keith A Hruska; A R Morrison
Bradykinin stimulates increased intracellular calcium in papillary collecting tubules of the rabbit.
Biochemical and biophysical research communications 1986;134(1):299-304.
1985: James A Shayman; A R Morrison
Bradykinin-induced changes in phosphatidyl inositol turnover in cultured rabbit papillary collecting tubule cells.
The Journal of clinical investigation 1985;76(3):978-84.
1981: P B Corr; James A Shayman; J B Kramer; R J Kipnis
Increased alpha-adrenergic receptors in ischemic cat myocardium. A potential mediator of electrophysiological derangements.
The Journal of clinical investigation 1981;67(4):1232-6.