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Gene Shearer

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Adriano Boasso; Mario Clerici; Spyridon Doumazos; Dietmar Fuchs; Sergio Lo Caputo; Francesco Mazzotta; Luca Piacentini; Caroline M Royle; Gene M Shearer; Barbara Tavano; Veronica N Aquino; Mara Biasin; David Raymond Graham
Overactivation of plasmacytoid dendritic cells inhibits antiviral T-cell responses: a model for HIV immunopathogenesis.
Troy J Kemp; Allan Hildesheim; Alfonso García-Piñeres; Marcus C Williams; Gene M Shearer; Ana Cecilia Rodriguez; Mark Schiffman; Robert D Burk; Enrique Freer; Jose Bonilla; Rolando Herrero; Ligia A Pinto
Elevated systemic levels of inflammatory cytokines in older women with persistent cervical human papillomavirus infection.
Mara Biasin; Luca Piacentini; Sergio Lo Caputo; Valentina Naddeo; Piera Pierotti; Manuela Borelli; Daria Trabattoni; Francesco Mazzotta; Gene M Shearer; Mario Clerici
TLR activation pathways in HIV-1-exposed seronegative individuals.

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All Publications

2011: Adriano Boasso; Mario Clerici; Spyridon Doumazos; Dietmar Fuchs; Sergio Lo Caputo; Francesco Mazzotta; Luca Piacentini; Caroline M Royle; Gene M Shearer; Barbara Tavano; Veronica N Aquino; Mara Biasin; David Raymond Graham
Overactivation of plasmacytoid dendritic cells inhibits antiviral T-cell responses: a model for HIV immunopathogenesis.
Blood 2011;118(19):5152-62.
2010: Troy J Kemp; Allan Hildesheim; Alfonso García-Piñeres; Marcus C Williams; Gene M Shearer; Ana Cecilia Rodriguez; Mark Schiffman; Robert D Burk; Enrique Freer; Jose Bonilla; Rolando Herrero; Ligia A Pinto
Elevated systemic levels of inflammatory cytokines in older women with persistent cervical human papillomavirus infection.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010;19(8):1954-9.
2010: Mara Biasin; Luca Piacentini; Sergio Lo Caputo; Valentina Naddeo; Piera Pierotti; Manuela Borelli; Daria Trabattoni; Francesco Mazzotta; Gene M Shearer; Mario Clerici
TLR activation pathways in HIV-1-exposed seronegative individuals.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(5):2710-7.
2009: Adriano Boasso; Monica Vaccari; Dietmar Fuchs; Andrew W Hardy; Wen-Po Tsai; Elzbieta Tryniszewska; Gene M Shearer; Genoveffa Franchini
Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4313-20.
2009: Jean-Philippe Herbeuval; Jakob Nilsson; Adriano Boasso; Andrew W Hardy; Monica Vaccari; Valentina Cecchinato; Valerio Valeri; Genoveffa Franchini; Jan Andersson; Gene M Shearer
HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaques.
AIDS (London, England) 2009;23(1):35-40.
2009: Miriam C Poirier; Ofelia A Olivero; Andrew W Hardy; Genoveffa Franchini; Jennifer P Borojerdi; Vernon E Walker; Dale M Walker; Gene M Shearer
Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo.
AIDS research and therapy 2009;6():24.
2008: Adriano Boasso; Andrew W Hardy; Alan L Landay; Jeffrey L Martinson; Stephanie A Anderson; Matthew J Dolan; Mario Clerici; Gene M Shearer
PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytes.
Clinical immunology (Orlando, Fla.) 2008;129(1):132-44.
2008: Oscar D Cano; Gabriele Neurauter; Dietmar Fuchs; Gene M Shearer; Adriano Boasso
Differential effect of type I and type II interferons on neopterin production and amino acid metabolism in human astrocyte-derived cells.
Neuroscience letters 2008;438(1):22-5.
2008: Adriano Boasso; Gene M Shearer; Mario Clerici
The hunt for an HIV vaccine: time to rethink recent failures.
Lancet 2008;371(9628):1897-8.
2008: Valentina Cecchinato; Elzbieta Tryniszewska; Zhong Min Ma; Monica Vaccari; Adriano Boasso; Wen-Po Tsai; Constantinos Petrovas; Dietmar Fuchs; Jean-Michel Heraud; David Venzon; Gene M Shearer; Richard A Koup; Israel Lowy; Christopher J Miller; Genoveffa Franchini
Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5439-47.
2008: Adriano Boasso; Gene M Shearer
Chronic innate immune activation as a cause of HIV-1 immunopathogenesis.
Clinical immunology (Orlando, Fla.) 2008;126(3):235-42.
2008: Adriano Boasso; Andrew W Hardy; Stephanie A Anderson; Matthew J Dolan; Gene M Shearer
HIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activation.
PloS one 2008;3(8):e2961.
2007: Adriano Boasso; Monica Vaccari; Anna Hryniewicz; Dietmar Fuchs; Janos Nacsa; Valentina Cecchinato; Jan Andersson; Genoveffa Franchini; Gene M Shearer; Claire Chougnet
Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection.
Journal of virology 2007;81(21):11593-603.
2007: Andrew W Hardy; David Raymond Graham; Gene M Shearer; Jean-Philippe Herbeuval
HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-alpha.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17453-8.
2007: Jean-Philippe Herbeuval; Gene M Shearer
HIV-1 immunopathogenesis: how good interferon turns bad.
Clinical immunology (Orlando, Fla.) 2007;123(2):121-8.
2007: Adriano Boasso; Jean-Philippe Herbeuval; Andrew W Hardy; Stephanie A Anderson; Matthew J Dolan; Dietmar Fuchs; Gene M Shearer
HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells.
Blood 2007;109(8):3351-9.
2007: Adriano Boasso; Gene M Shearer
How does indoleamine 2,3-dioxygenase contribute to HIV-mediated immune dysregulation.
Current drug metabolism 2007;8(3):217-23.
2007: Anna Hryniewicz; David A Price; Marcin Moniuszko; Adriano Boasso; Yvette Edghill-Spano; Sadie M West; David Venzon; Monica Vaccari; Wen-Po Tsai; Elzbieta Tryniszewska; Janos Nacsa; Francios VILLINGER; Aftab A Ansari; Christopher J Trindade; Michel MORRE; David Brooks; Philip M Arlen; Helen J Brown; Christina Kitchen; Jerome A Zack; Daniel C Douek; Gene M Shearer; Mark G Lewis; Richard A Koup; Genoveffa Franchini
Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3492-504.
2006: Jakob Nilsson; Adriano Boasso; Paula Andrea Velilla; Rui Zhang; Monica Vaccari; Genoveffa Franchini; Gene M Shearer; Jan Andersson; Claire Chougnet
HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS.
Blood 2006;108(12):3808-17.
2006: Anna Hryniewicz; Adriano Boasso; Yvette Edghill Spano; Monica Vaccari; Dietmar Fuchs; David Venzon; Janos Nacsa; Michael R Betts; Wen-Po Tsai; Jean-Michel Heraud; Brigitte Beer; Diann Blanset; Claire Chougnet; Israel Lowy; Gene M Shearer; Genoveffa Franchini
CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques.
Blood 2006;108(12):3834-42.
2006: Victoria I Bedoya; Adriano Boasso; Andrew W Hardy; Susanna M Rybak; Gene M Shearer; Maria T Rugeles
Ribonucleases in HIV type 1 inhibition: effect of recombinant RNases on infection of primary T cells and immune activation-induced RNase gene and protein expression.
AIDS research and human retroviruses 2006;22(9):897-907.
2006: Adriano Boasso; Monica Vaccari; Jakob Nilsson; Gene M Shearer; Jan Andersson; Valentina Cecchinato; Claire Chougnet; Genoveffa Franchini
Do regulatory T-cells play a role in AIDS pathogenesis?
AIDS reviews 2006;8(3):141-7.
2006: Jean-Philippe Herbeuval; Jakob Nilsson; Adriano Boasso; Andrew W Hardy; Michael J Kruhlak; Stephanie A Anderson; Matthew J Dolan; Michel Dy; Jan Andersson; Gene M Shearer
Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):7000-5.
2006: Jean-Philippe Herbeuval; Gene M Shearer
Are blockers of gp120/CD4 interaction effective inhibitors of HIV-1 immunopathogenesis?
AIDS reviews 2006;8(1):3-8.
2005: Jean-Philippe Herbeuval; Jean-Charles Grivel; Adriano Boasso; Andrew W Hardy; Claire Chougnet; Matthew J Dolan; Hideo Yagita; Jeffrey D Lifson; Gene M Shearer
CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis.
Blood 2005;106(10):3524-31.
2005: Jean-Philippe Herbeuval; Andrew W Hardy; Adriano Boasso; Stephanie A Anderson; Matthew J Dolan; Michel Dy; Gene M Shearer
Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):13974-9.
2005: Jan Andersson; Adriano Boasso; Jakob Nilsson; Rui Zhang; Norah Shire; Stefan Lindback; Gene M Shearer; Claire Chougnet
The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3143-7.
2005: Jean-Philippe Herbeuval; Adriano Boasso; Jean-Charles Grivel; Andrew W Hardy; Stephanie A Anderson; Matthew J Dolan; Claire Chougnet; Jeffrey D Lifson; Gene M Shearer
TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells.
Blood 2005;105(6):2458-64.
2005: Adriano Boasso; Jean-Philippe Herbeuval; Andrew W Hardy; Christiana Winkler; Gene M Shearer
Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells.
Blood 2005;105(4):1574-81.
2004: Maria T Rugeles; Gene M Shearer
Alloantigen recognition in utero: dual advantage for the fetus?
Trends in immunology 2004;25(7):348-52.
2003: Ligia A Pinto; Edith Grene; Robin Baker; Charles M Trubey; Naomi Torres; Matthew Trivett; Gene M Shearer
HIV inhibitory activity generated by antigen-stimulated cord blood leukocytes.
AIDS (London, England) 2003;17(9):1389-92.
2003: Daria Trabattoni; Marina Saresella; Mara Biasin; Adriano Boasso; Luca Piacentini; Pasquale Ferrante; Haidong Dong; Renato Maserati; Gene M Shearer; Lieping Chen; Mario Clerici
B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression.
Blood 2003;101(7):2514-20.
2003: Maria T Rugeles; Charles M Trubey; Victoria I Bedoya; Ligia A Pinto; Joost J Oppenheim; Susanna M Rybak; Gene M Shearer
Ribonuclease is partly responsible for the HIV-1 inhibitory effect activated by HLA alloantigen recognition.
AIDS (London, England) 2003;17(4):481-6.
2002: Kenichi Sakurai; Jian-Ping Zou; N I Torres; Jolynne R Tschetter; H-s Kim; Gene M Shearer
Study of the effect of indoleamine 2,3-dioxygenase on murine mixed lymphocyte reactions and skin allograft rejection.
Transplantation proceedings 2002;34(8):3271-3.
2002: Otto O Yang; W John Boscardin; Jose Matud; Mary Ann Hausner; Lance E Hultin; Patricia M Hultin; Roger Shih; John Ferbas; Frederick P Siegal; Michael Shodell; Gene M Shearer; Edith Grene; Mary Carrington; Steve O'Brien; Charles B Price; Roger Detels; Beth D Jamieson; Janis V Giorgi
Immunologic profile of highly exposed yet HIV type 1-seronegative men.
AIDS research and human retroviruses 2002;18(14):1051-65.
2002: Kenichi Sakurai; Jian-Ping Zou; Jolynne R Tschetter; Jerrold M Ward; Gene M Shearer
Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 2002;129(1-2):186-96.
2001: Yi-Fu Yang; Michio Tomura; Masayuki Iwasaki; Shiro Ono; Jian-Ping Zou; K Uno; Gene M Shearer; Hiromi Fujiwara; Toshiyuki Hamaoka
IFN-alpha acts on T-cell receptor-triggered human peripheral leukocytes to up-regulate CCR5 expression on CD4+ and CD8+ T cells.
Journal of clinical immunology 2001;21(6):402-9.
2001: V Blazevic; Shirley Jankelevich; Seth M Steinberg; F Jacobsen; Robert Yarchoan; Gene M Shearer
Highly active antiretroviral therapy in human immunodeficiency virus type 1-infected children: analysis of cellular immune responses.
Clinical and diagnostic laboratory immunology 2001;8(5):943-8.
2001: Claire Chougnet; Shirley Jankelevich; Keith R Fowke; David J Liewehr; Seth M Steinberg; BU Mueller; PA Pizzo; Robert Yarchoan; Gene M Shearer
Long-term protease inhibitor-containing therapy results in limited improvement in T cell function but not restoration of interleukin-12 production in pediatric patients with AIDS.
The Journal of infectious diseases 2001;184(2):201-5.
2001: V Blazevic; Charles M Trubey; Gene M Shearer
Analysis of the costimulatory requirements for generating human virus-specific in vitro T helper and effector responses.
Journal of clinical immunology 2001;21(4):293-302.
2001: Frances T Hakim; Daniel H Fowler; Gene M Shearer; Ronald E Gress
Animal models of acute and chronic graft-versus-host disease.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 4():Unit 4.3.
2001: C Freitag; Claire Chougnet; Marco L Schito; K A Near; Gene M Shearer; C Li; J Langhorne; Alan Sher
Malaria infection induces virus expression in human immunodeficiency virus transgenic mice by CD4 T cell-dependent immune activation.
The Journal of infectious diseases 2001;183(8):1260-8.
2001: Ligia A Pinto; V Blazevic; Stephanie A Anderson; DJ Venzon; Charles M Trubey; Thomas Rowe; J M Katz; David J Liewehr; Matthew J Dolan; Gene M Shearer
Influenza virus-stimulated generation of anti-human immunodeficiency virus (HIV) activity after influenza vaccination in HIV-infected individuals and healthy control subjects.
The Journal of infectious diseases 2001;183(7):1000-8.
2001: Yi-Fu Yang; Michio Tomura; Masayuki Iwasaki; Tetsu Mukai; Ping Gao; Shiro Ono; Jian-Ping Zou; Gene M Shearer; Hiromi Fujiwara; Toshiyuki Hamaoka
IL-12 as well as IL-2 upregulates CCR5 expression on T cell receptor-triggered human CD4+ and CD8+ T cells.
Journal of clinical immunology 2001;21(2):116-25.
2001: Claire Chougnet; C Freitag; Marco L Schito; Elaine K Thomas; Alan Sher; Gene M Shearer
In vivo CD40-CD154 (CD40 ligand) interaction induces integrated HIV expression by APC in an HIV-1-transgenic mouse model.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3210-7.
2001: Edith Grene; Ligia A Pinto; Alan L Landay; Harold A Kessler; Stephanie A Anderson; Matthew J Dolan; Gene M Shearer
Anti-CCR5 antibodies in sera of HIV-positive individuals.
Human immunology 2001;62(2):143-5.
2001: Edith Grene; Ligia A Pinto; SS Cohen; Matthew Trivett; TB Simonis; David J Liewehr; Seth M Steinberg; Gene M Shearer
Generation of alloantigen-stimulated anti-human immunodeficiency virus activity is associated with HLA-A*02 expression.
The Journal of infectious diseases 2001;183(3):409-16.
2000: Keith R Fowke; Rupert Kaul; K L Rosenthal; Julius Oyugi; Joshua Kimani; WJ Rutherford; Nico J D Nagelkerke; T Blake Ball; Job J Bwayo; J Neil Simonsen; Gene M Shearer; Francis A Plummer
HIV-1-specific cellular immune responses among HIV-1-resistant sex workers.
Immunology and cell biology 2000;78(6):586-95.
2000: V Blazevic; N Sahgal; Harold A Kessler; Alan L Landay; Gene M Shearer
T cell responses to recall antigens, alloantigen, and mitogen of HIV-infected patients receiving long-term combined antiretroviral therapy.
AIDS research and human retroviruses 2000;16(17):1887-93.
2000: Jolynne R Tschetter; Edna Mozes; Gene M Shearer
Progression from acute to chronic disease in a murine parent-into-F1 model of graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5987-94.
2000: Edith Grene; Ligia A Pinto; Joanne Kwak-Kim; Janis V Giorgi; Alan L Landay; Harold A Kessler; A E Beer; Gene M Shearer
Increased levels of anti-CCR5 antibodies in sera from individuals immunized with allogeneic lymphocytes.
AIDS (London, England) 2000;14(16):2627-8.
2000: Ofelia A Olivero; Gene M Shearer; Claire Chougnet; Andrea Kovacs; R Baker; Alice Stek; M M Khoury; Miriam C Poirier
Incorporation of zidovudine into cord blood DNA of infants and peripheral blood DNA of their HIV-1-positive mothers.
Annals of the New York Academy of Sciences 2000;918():262-8.
2000: Ligia A Pinto; Gene M Shearer; V Blazevic
Immune-based approaches for control of HIV infection and viral-induced immunopathogenesis.
Clinical immunology (Orlando, Fla.) 2000;97(1):1-8.
2000: V Blazevic; Charles M Trubey; Gene M Shearer
Comparison of in vitro immunostimulatory potential of live and inactivated influenza viruses.
Human immunology 2000;61(9):845-9.
2000: Edith Grene; Danforth A Newton; E A Brown; Jay A Berzofsky; Sebastiano Gattoni-Celli; Gene M Shearer
Semi-allogeneic cell hybrids stimulate HIV-1 envelope-specific cytotoxic T lymphocytes.
AIDS (London, England) 2000;14(11):1497-506.
2000: Ligia A Pinto; Mark S Williams; Matthew J Dolan; Pierre A Henkart; Gene M Shearer
Beta-chemokines inhibit activation-induced death of lymphocytes from HIV-infected individuals.
European journal of immunology 2000;30(7):2048-55.
2000: V Blazevic; Ligia A Pinto; Charles M Trubey; Gene M Shearer
Alloantigenic stimulation bypasses CD28-B7 costimulatory blockade by an interleukin-2-dependent mechanism.
Journal of leukocyte biology 2000;67(6):817-24.
2000: Claire Chougnet; Andrea Kovacs; R Baker; BU Mueller; N L Luban; David J Liewehr; Seth M Steinberg; Elaine K Thomas; Gene M Shearer
Influence of human immunodeficiency virus-infected maternal environment on development of infant interleukin-12 production.
The Journal of infectious diseases 2000;181(5):1590-7.
2000: Ligia A Pinto; V Blazevic; B K Patterson; C Mac Trubey; Matthew J Dolan; Gene M Shearer
Inhibition of human immunodeficiency virus type 1 replication prior to reverse transcription by influenza virus stimulation.
Journal of virology 2000;74(10):4505-11.
2000: Ligia A Pinto; V Blazevic; Gene M Shearer; B K Patterson; Matthew J Dolan
Alloantigen-induced anti-HIV activity occurs prior to reverse transcription and can be generated by leukocytes from HIV-infected individuals.
Blood 2000;95(5):1875-6.
1999: Howard D Strickler; James J Goedert; F R Bethke; Charles M Trubey; T R O'Brien; Joel Palefsky; James E Whitman; Dharam V Ablashi; S Zeichner; Gene M Shearer
Human herpesvirus 8 cellular immune responses in homosexual men.
The Journal of infectious diseases 1999;180(5):1682-5.
1999: Ligia A Pinto; Jay A Berzofsky; Keith R Fowke; Richard F Little; F Merced-Galindez; Rachel Humphrey; Jeffrey D Ahlers; N Dunlop; R B Cohen; Seth M Steinberg; PL Nara; Gene M Shearer; Robert Yarchoan
HIV-specific immunity following immunization with HIV synthetic envelope peptides in asymptomatic HIV-infected patients.
AIDS (London, England) 1999;13(15):2003-12.
1999: Claire Chougnet; SS Cohen; Tatsuyoshi Kawamura; Alan L Landay; Harold A Kessler; E Thomas; Andrew Blauvelt; Gene M Shearer
Normal immune function of monocyte-derived dendritic cells from HIV-infected individuals: implications for immunotherapy.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1666-73.
1999: Timothy Doherty; Claire Chougnet; Marco L Schito; B K Patterson; C Fox; Gene M Shearer; G Englund; Alan Sher
Infection of HIV-1 transgenic mice with Mycobacterium avium induces the expression of infectious virus selectively from a Mac-1-positive host cell population.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1506-15.
1999: R D'Amico; Ligia A Pinto; P Meyer; Alan L Landay; A A Harris; Mario Clerici; J A Berzofsky; Gene M Shearer; Harold A Kessler
Effect of zidovudine postexposure prophylaxis on the development of HIV-specific cytotoxic T-lymphocyte responses in HIV-exposed healthcare workers.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 1999;20(6):428-30.
1999: Ofelia A Olivero; Gene M Shearer; Claire Chougnet; Andrea Kovacs; Alan L Landay; R Baker; Alice Stek; M M Khoury; Laurie A Proia; Harold A Kessler; Beverly E Sha; R E Tarone; Miriam C Poirier
Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero.
AIDS (London, England) 1999;13(8):919-25.
1999: Jian-Ping Zou; Lorri A Morford; Claire Chougnet; A R Dix; Andrew G Brooks; N Torres; Jon Shuman; John E Coligan; William H Brooks; Thomas L Roszman; Gene M Shearer
Human glioma-induced immunosuppression involves soluble factor(s) that alters monocyte cytokine profile and surface markers.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4882-92.
1999: Gene M Shearer; Ligia A Pinto; Mario Clerici
Alloimmunization for immune-based therapy and vaccine design against HIV/AIDS.
Immunology today 1999;20(2):66-71.
1998: Claire Chougnet; Keith R Fowke; BU Mueller; S Smith; J Zuckerman; S Jankelevitch; Seth M Steinberg; N Luban; PA Pizzo; Gene M Shearer
Protease inhibitor and triple-drug therapy: cellular immune parameters are not restored in pediatric AIDS patients after 6 months of treatment.
AIDS (London, England) 1998;12(18):2397-406.
1998: Keith R Fowke; Tao Dong; Sarah L Rowland-Jones; Julius Oyugi; WJ Rutherford; Joshua Kimani; P Krausa; Job Bwayo; J Neil Simonsen; Gene M Shearer; Francis A Plummer
HIV type 1 resistance in Kenyan sex workers is not associated with altered cellular susceptibility to HIV type 1 infection or enhanced beta-chemokine production.
AIDS research and human retroviruses 1998;14(17):1521-30.
1998: Ligia A Pinto; S Sharpe; DI Cohen; Gene M Shearer
Alloantigen-stimulated anti-HIV activity.
Blood 1998;92(9):3346-54.
1998: Gene M Shearer; M Clerici
Cytokine profiles in HIV type 1 disease and protection.
AIDS research and human retroviruses 1998;14 Suppl 2():S149-52.
1998: Claire Chougnet; E Thomas; Alan L Landay; Harold A Kessler; S Buchbinder; S Scheer; Gene M Shearer
CD40 ligand and IFN-gamma synergistically restore IL-12 production in HIV-infected patients.
European journal of immunology 1998;28(2):646-56.
1998: Federica Pericle; Ligia A Pinto; S Hicks; Robert A Kirken; G Sconocchia; J Rusnak; Matthew J Dolan; Gene M Shearer; David M Segal
HIV-1 infection induces a selective reduction in STAT5 protein expression.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):28-31.
1997: M Clerici; A Sarin; Pierre A Henkart; Gene M Shearer
Apoptotic cell death and cytokine dysregulation in human immunodeficiency virus infection: pivotal factors in disease progression.
Cell death and differentiation 1997;4(8):699-706.
1997: BB Mittleman; F X Castellanos; Leslie K Jacobsen; Judy Rapoport; Susan E Swedo; Gene M Shearer
Cerebrospinal fluid cytokines in pediatric neuropsychiatric disease.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2994-9.
1997: Keith R Fowke; R D'Amico; D N Chernoff; J C Pottage; Constance A Benson; Beverly E Sha; Harold A Kessler; Alan L Landay; Gene M Shearer
Immunologic and virologic evaluation after influenza vaccination of HIV-1-infected patients.
AIDS (London, England) 1997;11(8):1013-21.
1997: Ligia A Pinto; Alan L Landay; Jay A Berzofsky; Harold A Kessler; Gene M Shearer
Immune response to human immunodeficiency virus (HIV) in healthcare workers occupationally exposed to HIV-contaminated blood.
The American journal of medicine 1997;102(5B):21-4.
1997: Gene M Shearer; M Clerici
Vaccine strategies: selective elicitation of cellular or humoral immunity?
Trends in biotechnology 1997;15(3):106-9.
1997: Daniel R Lucey; Ligia A Pinto; F R Bethke; J Rusnak; G P Melcher; F N Hashemi; Alan L Landay; Harold A Kessler; R J Paxton; Kenneth H Grabstein; Gene M Shearer
In vitro immunologic and virologic effects of interleukin 15 on peripheral blood mononuclear cells from normal donors and human immunodeficiency virus type 1-infected patients.
Clinical and diagnostic laboratory immunology 1997;4(1):43-8.
1996: BB Mittleman; Gene M Shearer
Mother-to-infant transmission of HIV type 1: role of major histocompatibility antigen differences.
AIDS research and human retroviruses 1996;12(15):1397-400.
1996: Claire Chougnet; David M Margolis; Alan L Landay; Harold A Kessler; Gene M Shearer
Contribution of prostaglandin E2 to the interleukin-12 defect in HIV-infected patients.
AIDS (London, England) 1996;10(9):1043-5.
1996: Mario Clerici; Claudia Balotta; Luca Meroni; E Ferrario; Chiara Riva; D Trabattoni; Anna Lisa Ridolfo; M Villa; Gene M Shearer; Mauro Moroni; Massimo Galli
Type 1 cytokine production and low prevalence of viral isolation correlate with long-term nonprogression in HIV infection.
AIDS research and human retroviruses 1996;12(11):1053-61.
1996: BB Mittleman; Herbert C Morse; S M Payne; Gene M Shearer; Edna Mozes
Amelioration of experimental systemic lupus erythematosus (SLE) by retrovirus infection.
Journal of clinical immunology 1996;16(4):230-6.
1996: Claire Chougnet; T A Wynn; Mario Clerici; Alan L Landay; Harold A Kessler; J Rusnak; G P Melcher; Alan Sher; Gene M Shearer
Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus.
The Journal of infectious diseases 1996;174(1):46-53.
1996: L L Lewis; David Venzon; J Church; M Farley; S Wheeler; A Keller; M Rubin; G Yuen; B Mueller; M Sloas; L Wood; FRANK BALIS; Gene M Shearer; Pim Brouwers; J Goldsmith; PA Pizzo
Lamivudine in children with human immunodeficiency virus infection: a phase I/II study. The National Cancer Institute Pediatric Branch-Human Immunodeficiency Virus Working Group.
The Journal of infectious diseases 1996;174(1):16-25.
1996: Mario Clerici; Gene M Shearer
Correlates of protection in HIV infection and the progression of HIV infection to AIDS.
Immunology letters 1996;51(1-2):69-73.
1996: Mario Clerici; A Sarin; Jay A Berzofsky; Alan L Landay; Harold A Kessler; F Hashemi; Craig W Hendrix; S P Blatt; J Rusnak; Matthew J Dolan; R L Coffman; Pierre A Henkart; Gene M Shearer
Antigen-stimulated apoptotic T-cell death in HIV infection is selective for CD4+ T cells, modulated by cytokines and effected by lymphotoxin.
AIDS (London, England) 1996;10(6):603-11.
1996: Claire Chougnet; Gene M Shearer
Potential clinical applications of interleukin-12.
Current opinion in hematology 1996;3(3):216-22.
1996: Alan L Landay; Mario Clerici; F Hashemi; H Kessler; Jay A Berzofsky; Gene M Shearer
In vitro restoration of T cell immune function in human immunodeficiency virus-positive persons: effects of interleukin (IL)-12 and anti-IL-10.
The Journal of infectious diseases 1996;173(5):1085-91.
1996: Andrew Blauvelt; Claire Chougnet; Gene M Shearer; Stephen I Katz
Modulation of T cell responses to recall antigens presented by Langerhans cells in HIV-discordant identical twins by anti-interleukin (IL)-10 antibodies and IL-12.
The Journal of clinical investigation 1996;97(6):1550-5.
1996: Gene M Shearer; Mario Clerici
Protective immunity against HIV infection: has nature done the experiment for us?
Immunology today 1996;17(1):21-4.
1995: Claire Chougnet; Mario Clerici; Gene M Shearer
Role of IL12 in HIV disease/AIDS.
Research in immunology 1995;146(7-8):615-22.
1995: Ligia A Pinto; J Sullivan; Jay A Berzofsky; Mario Clerici; Harold A Kessler; Alan L Landay; Gene M Shearer
ENV-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids.
The Journal of clinical investigation 1995;96(2):867-76.
1995: S Sugihara; H Fujiwara; H Niimi; Gene M Shearer
Self-thyroid epithelial cell (TEC)-reactive CD8+ T cell lines/clones derived from autoimmune thyroiditis lesions. They recognize self-thyroid antigens directly on TEC to exhibit T helper cell 1-type lymphokine production and cytotoxicity against TEC.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1619-28.
1995: Andrew Blauvelt; Mario Clerici; D R Lucey; S M Steinberg; Robert Yarchoan; R Walker; Gene M Shearer; Stephen I Katz
Functional studies of epidermal Langerhans cells and blood monocytes in HIV-infected persons.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(7):3506-15.
1995: Mario Clerici; Gene M Shearer
An Occam's razor approach to the immunopathogenesis of HIV infection.
AIDS (London, England) 1995;9 Suppl A():S33-40.
1995: Gene M Shearer; Mario Clerici; A Sarin; Jay A Berzofsky; Pierre A Henkart
Cytokines in immune regulation/pathogenesis in HIV infection.
Ciba Foundation symposium 1995;195():142-7; discussion 147-53.
1994: Mario Clerici; A Sarin; R L Coffman; T A Wynn; S P Blatt; Craig W Hendrix; Stanley Wolf; Gene M Shearer; Pierre A Henkart
Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):11811-5.
1994: Mario Clerici; Gene M Shearer
The Th1-Th2 hypothesis of HIV infection: new insights.
Immunology today 1994;15(12):575-81.
1994: Mario Clerici; Edward A Clark; Patricia Polacino; I Axberg; Lewis H Kuller; N I Casey; William R Morton; Gene M Shearer; Raoul E Benveniste
T-cell proliferation to subinfectious SIV correlates with lack of infection after challenge of macaques.
AIDS (London, England) 1994;8(10):1391-5.
1994: B L Bermas; Michelle Petri; Jay A Berzofsky; Ari Waisman; Gene M Shearer; Edna Mozes
Binding of glycoprotein 120 and peptides from the HIV-1 envelope by autoantibodies in mice with experimentally induced systemic lupus erythematosus and in patients with the disease.
AIDS research and human retroviruses 1994;10(9):1071-7.
1994: A Sarin; Mario Clerici; S P Blatt; Craig W Hendrix; Gene M Shearer; Pierre A Henkart
Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(2):862-72.
1994: B L Bermas; Michelle Petri; D Goldman; BB Mittleman; M W Miller; N I Stocks; Charles S Via; Gene M Shearer
T helper cell dysfunction in systemic lupus erythematosus (SLE): relation to disease activity.
Journal of clinical immunology 1994;14(3):169-77.
1994: Mario Clerici; T A Wynn; Jay A Berzofsky; S P Blatt; Craig W Hendrix; Alan Sher; R L Coffman; Gene M Shearer
Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus.
The Journal of clinical investigation 1994;93(2):768-75.
1994: Richard D Schulick; S C Muluk; Mario Clerici; B L Bermas; Charles S Via; Matthew R Weir; Gene M Shearer
Value of in vitro CD4+ T helper cell function test for predicting long-term loss of human renal allografts.
Transplantation 1994;57(3):480-2.
1994: Mario Clerici; J M Levin; Harold A Kessler; A Harris; Jay A Berzofsky; Alan L Landay; Gene M Shearer
HIV-specific T-helper activity in seronegative health care workers exposed to contaminated blood.
JAMA : the journal of the American Medical Association 1994;271(1):42-6.
1994: Frances T Hakim; S Payne; Gene M Shearer
Recovery of T cell populations after acute graft-vs-host reaction.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(1):58-64.
1994: Mario Clerici; E Ferrario; D Trabattoni; Simonetta Viviani; V Bonfanti; D J Venzon; E Clerici; Gene M Shearer; Maria Luisa Villa
Multiple defects of T helper cell function in newly diagnosed patients with Hodgkin's disease.
European journal of cancer (Oxford, England : 1990) 1994;30A(10):1464-70.
1993: Mario Clerici; D R Lucey; Jay A Berzofsky; Ligia A Pinto; T A Wynn; S P Blatt; Matthew J Dolan; Craig W Hendrix; Stanley Wolf; Gene M Shearer
Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro.
Science (New York, N.Y.) 1993;262(5140):1721-4.
1993: Mario Clerici; Robert Yarchoan; S Blatt; Craig W Hendrix; A J Ammann; S Broder; Gene M Shearer
Effect of a recombinant CD4-IgG on in vitro T helper cell function: data from a phase I/II study of patients with AIDS.
The Journal of infectious diseases 1993;168(4):1012-6.
1993: Charles S Via; G C Tsokos; B Bermas; Mario Clerici; Gene M Shearer
T cell-antigen-presenting cell interactions in human systemic lupus erythematosus. Evidence for heterogeneous expression of multiple defects.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(7):3914-22.
1993: Richard D Schulick; Matthew R Weir; M W Miller; D J Cohen; B L Bermas; Gene M Shearer
Longitudinal study of in vitro CD4+ T helper cell function in recently transplanted renal allograft patients undergoing tapering of their immunosuppressive drugs.
Transplantation 1993;56(3):590-6.
1993: Mario Clerici; L DePalma; Emmanuel Roilides; R Baker; Gene M Shearer
Analysis of T helper and antigen-presenting cell functions in cord blood and peripheral blood leukocytes from healthy children of different ages.
The Journal of clinical investigation 1993;91(6):2829-36.
1993: Mario Clerici; Frances T Hakim; D J Venzon; S Blatt; Craig W Hendrix; T A Wynn; Gene M Shearer
Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.
The Journal of clinical investigation 1993;91(3):759-65.
1993: Mario Clerici; Gene M Shearer
A TH1-->TH2 switch is a critical step in the etiology of HIV infection.
Immunology today 1993;14(3):107-11.
1993: Richard D Schulick; Mario Clerici; Matthew J Dolan; Gene M Shearer
Limiting dilution analysis of interleukin-2-producing T cells responsive to recall and alloantigens in human immunodeficiency virus-infected and uninfected individuals.
European journal of immunology 1993;23(2):412-7.
1993: S Sugihara; H Fujiwara; Gene M Shearer
Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. Characterization of thyroiditis-inducing T cell lines and clones derived from thyroid lesions.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(2):683-94.
1993: Gene M Shearer; Mario Clerici
Abnormalities of immune regulation in human immunodeficiency virus infection.
Pediatric research 1993;33(1 Suppl):S71-4; discussion S74-5.
1992: Mario Clerici; Emmanuel Roilides; K M Butler; L DePalma; David Venzon; Gene M Shearer; PA Pizzo
Changes in T-helper cell function in human immunodeficiency virus-infected children during didanosine therapy as a measure of antiretroviral activity.
Blood 1992;80(9):2196-202.
1992: Mario Clerici; Alan L Landay; Harold A Kessler; J P Phair; D J Venzon; Craig W Hendrix; D R Lucey; Gene M Shearer
Reconstitution of long-term T helper cell function after zidovudine therapy in human immunodeficiency virus-infected patients.
The Journal of infectious diseases 1992;166(4):723-30.
1992: Mario Clerici; Emmanuel Roilides; Charles S Via; PA Pizzo; Gene M Shearer
A factor from CD8 cells of human immunodeficiency virus-infected patients suppresses HLA self-restricted T helper cell responses.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8424-8.
1992: S C Muluk; Frances T Hakim; Gene M Shearer
Regulation of graft-versus-host-reaction by Mlsa-reactive donor T cells.
European journal of immunology 1992;22(8):1967-73.
1992: Gene M Shearer; Mario Clerici
How human immunodeficiency virus ravages the immune system.
Current opinion in immunology 1992;4(4):463-5.
1992: Mario Clerici; Janis V Giorgi; C C Chou; V K Gudeman; J A Zack; P Gupta; H N Ho; P G Nishanian; Jay A Berzofsky; Gene M Shearer
Cell-mediated immune response to human immunodeficiency virus (HIV) type 1 in seronegative homosexual men with recent sexual exposure to HIV-1.
The Journal of infectious diseases 1992;165(6):1012-9.
1992: Gene M Shearer; Mario Clerici
T helper cell immune dysfunction in asymptomatic, HIV-1-seropositive individuals: the role of TH1-TH2 cross-regulation.
Chemical immunology 1992;54():21-43.
1991: A S De Groot; Mario Clerici; A Hosmalin; S H Hughes; D Barnd; Craig W Hendrix; R Houghten; Gene M Shearer; Jay A Berzofsky
Human immunodeficiency virus reverse transcriptase T helper epitopes identified in mice and humans: correlation with a cytotoxic T cell epitope.
The Journal of infectious diseases 1991;164(6):1058-65.
1991: Frances T Hakim; R T Gazzinelli; Eric Y Denkers; Sara Hieny; Gene M Shearer; Alan Sher
CD8+ T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(7):2310-6.
1991: Jay A Berzofsky; C David Pendleton; Mario Clerici; Jeffrey D Ahlers; D R Lucey; S D Putney; Gene M Shearer
Construction of peptides encompassing multideterminant clusters of human immunodeficiency virus envelope to induce in vitro T cell responses in mice and humans of multiple MHC types.
The Journal of clinical investigation 1991;88(3):876-84.
1991: S C Muluk; Mario Clerici; Charles S Via; Matthew R Weir; P L Kimmel; Gene M Shearer
Correlation of in vitro CD4+ T helper cell function with clinical graft status in immunosuppressed kidney transplant recipients.
Transplantation 1991;52(2):284-91.
1991: Mario Clerici; Jay A Berzofsky; Gene M Shearer; Carol O Tacket
Exposure to human immunodeficiency virus (HIV) type I indicated by HIV-specific T helper cell responses before detection of infection by polymerase chain reaction and serum antibodies [corrected].
The Journal of infectious diseases 1991;164(1):178-82.
1991: Mario Clerici; Carol O Tacket; Charles S Via; D R Lucey; S C Muluk; R A Zajac; R N Boswell; Jay A Berzofsky; Gene M Shearer
Immunization with subunit human immunodeficiency virus vaccine generates stronger T helper cell immunity than natural infection.
European journal of immunology 1991;21(6):1345-9.
1991: Emmanuel Roilides; Mario Clerici; L DePalma; M Rubin; PA Pizzo; Gene M Shearer
Helper T-cell responses in children infected with human immunodeficiency virus type 1.
The Journal of pediatrics 1991;118(5):724-30.
1991: Mario Clerici; D R Lucey; R A Zajac; R N Boswell; Howard M. Gebel; H Takahashi; Jay A Berzofsky; Gene M Shearer
Detection of cytotoxic T lymphocytes specific for synthetic peptides of gp160 in HIV-seropositive individuals.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2214-9.
1991: Mario Clerici; Alan L Landay; Harold A Kessler; R A Zajac; R N Boswell; S C Muluk; Gene M Shearer
Multiple patterns of alloantigen presenting/stimulating cell dysfunction in patients with AIDS.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2207-13.
1991: Frances T Hakim; Susan O Sharrow; S Payne; Gene M Shearer
Repopulation of host lymphohematopoietic systems by donor cells during graft-versus-host reaction in unirradiated adult F1 mice injected with parental lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2108-15.
1991: A Kosugi; Gene M Shearer
Effect of cyclosporin A on lymphopoiesis. III. Augmentation of the generation of natural killer cells in bone marrow transplanted mice treated with cyclosporin A.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(5):1416-21.
1991: Mario Clerici; Charles S Via; D R Lucey; Emmanuel Roilides; PA Pizzo; Gene M Shearer
Functional dichotomy of CD4+ T helper lymphocytes in asymptomatic human immunodeficiency virus infection.
European journal of immunology 1991;21(3):665-70.
1991: S C Muluk; Mario Clerici; Charles S Via; M R Wier; P L Kimmel; Gene M Shearer
A new approach for analysis of the mixed lymphocyte reaction that is predictive for human renal allograft rejection.
Transplantation proceedings 1991;23(1 Pt 2):1274-6.
1991: D Fuchs; Gene M Shearer; R N Boswell; D R Lucey; Mario Clerici; G Reibnegger; Ernst R Werner; R A Zajac; H Wachter
Negative correlation between blood cell counts and serum neopterin concentration in patients with HIV-1 infection.
AIDS (London, England) 1991;5(2):209-12.
1991: Jay A Berzofsky; C David Pendleton; Mario Clerici; Jeffrey D Ahlers; D R Lucey; S D Putney; Gene M Shearer
Peptides containing multideterminant clusters of human immunodeficiency virus envelope induce murine and human T-cell responses in diverse histocompatibility types.
Transactions of the Association of American Physicians 1991;104():69-77.
1991: R Blackburn; Mario Clerici; Dean L Mann; D R Lucey; J Goedert; Basil Golding; Gene M Shearer; Hana Golding
Common sequence in HIV 1 GP41 and HLA class II beta chains can generate crossreactive autoantibodies with immunosuppressive potential early in the course of HIV 1 infection.
Advances in experimental medicine and biology 1991;303():63-9.
1990: S C Muluk; Frances T Hakim; Gene M Shearer
Murine cytomegalovirus infection can enhance hybrid resistance through modulation of host natural killer activity.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(4):1113-9.
1990: Charles S Via; Herbert C Morse; Gene M Shearer
Altered immunoregulation and autoimmune aspects of HIV infection: relevant murine models.
Immunology today 1990;11(7):250-5.
1990: P J Lucas; Gene M Shearer; S Neudorf; Ronald E Gress
The human antimurine xenogeneic cytotoxic response. I. Dependence on responder antigen-presenting cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(12):4548-54.
1990: Mario Clerici; N I Stocks; R A Zajac; R N Boswell; Charles S Via; Gene M Shearer
Circumvention of defective CD4 T helper cell function in HIV-infected individuals by stimulation with HLA alloantigens.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(9):3266-71.
1990: Frances T Hakim; D H Pluznik; Gene M Shearer
Factors contributing to the decrease in concanavalin A-induced colony-stimulating factors in acute suppressive graft-versus-host disorder.
Transplantation 1990;49(4):781-7.
1990: Frances T Hakim; D H Pluznik; Gene M Shearer
Alterations in T cell-derived colony-stimulating factors associated with GVH-induced immune deficiency.
Transplantation 1990;49(4):773-81.
1990: D Fuchs; Gene M Shearer; R N Boswell; Mario Clerici; G Reibnegger; Ernst R Werner; R A Zajac; H Wachter
Increased serum neopterin in patients with HIV-1 infection is correlated with reduced in vitro interleukin-2 production.
Clinical and experimental immunology 1990;80(1):44-8.
1990: Charles S Via; G C Tsokos; N I Stocks; Mario Clerici; Gene M Shearer
Human in vitro allogeneic responses. Demonstration of three pathways of T helper cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(7):2524-8.
1990: Mario Clerici; Gene M Shearer
Differential sensitivity of human T helper cell pathways by in vitro exposure to cyclosporin A.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(7):2480-5.
1990: A Hosmalin; Mario Clerici; R Houghten; C David Pendleton; Charles Flexner; D R Lucey; Bernard Moss; R N Germain; Gene M Shearer; Jay A Berzofsky
An epitope in human immunodeficiency virus 1 reverse transcriptase recognized by both mouse and human cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(6):2344-8.
1990: Mario Clerici; N I Stocks; R A Zajac; R N Boswell; Gene M Shearer
Accessory cell function in asymptomatic human immunodeficiency virus-infected patients.
Clinical immunology and immunopathology 1990;54(2):168-73.
1989: Mario Clerici; N I Stocks; R A Zajac; R N Boswell; D R Lucey; Charles S Via; Gene M Shearer
Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging.
The Journal of clinical investigation 1989;84(6):1892-9.
1989: A Kosugi; J C Zuniga-Pflucker; Susan O Sharrow; A M Kruisbeek; Gene M Shearer
Effect of cyclosporin A on lymphopoiesis. II. Developmental defects of immature and mature thymocytes in fetal thymus organ cultures treated with cyclosporin A.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(10):3134-40.
1989: S C Muluk; D C Bernstein; Gene M Shearer
A virus-sensitive suppressor cell is involved in the regulation of human allospecific T cell-mediated cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(7):2209-15.
1989: M Fukuzawa; Susan O Sharrow; Gene M Shearer
Effect of cyclosporin A on T cell immunity. II. Defective thymic education of CD4 T helper cell function in cyclosporin A-treated mice.
European journal of immunology 1989;19(6):1147-52.
1989: Mario Clerici; N I Stocks; R A Zajac; R N Boswell; D C Bernstein; Dean L Mann; Gene M Shearer; Jay A Berzofsky
Interleukin-2 production used to detect antigenic peptide recognition by T-helper lymphocytes from asymptomatic HIV-seropositive individuals.
Nature 1989;339(6223):383-5.
1989: A Kosugi; Susan O Sharrow; Gene M Shearer
Effect of cyclosporin A on lymphopoiesis. I. Absence of mature T cells in thymus and periphery of bone marrow transplanted mice treated with cyclosporin A.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(9):3026-32.
1989: Charles S Via; Gene M Shearer
Autoimmunity and the acquired immune deficiency syndrome.
Current opinion in immunology 1989;1(4):753-6.
1989: Hana Golding; Gene M Shearer; K Hillman; P Lucas; Jody Manischewitz; R A Zajac; Mario Clerici; R E Gress; R N Boswell; Basil Golding
Common epitope in human immunodeficiency virus (HIV) I-GP41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune dysfunction in HIV I-infected individuals.
The Journal of clinical investigation 1989;83(4):1430-5.
1989: Gene M Shearer
Some immunologic questions and predictions associated with the development of acquired immune deficiency syndrome.
Current problems in dermatology 1989;18():236-40.
1989: M Fukuzawa; Gene M Shearer
Effect of cyclosporin A on T cell immunity. I. Dose-dependent suppression of different murine T helper cell pathways.
European journal of immunology 1989;19(1):49-56.
1988: Charles S Via; Gene M Shearer
Functional heterogeneity of L3T4+ T cells in MRL-lpr/lpr mice. L3T4+ T cells suppress major histocompatibility complex-self-restricted L3T4+ T helper cell function in association with autoimmunity.
The Journal of experimental medicine 1988;168(6):2165-81.
1988: J D Shanley; Claire Pomeroy; Charles S Via; Gene M Shearer
Interstitial pneumonitis during murine cytomegalovirus infection and graft-versus-host reaction: effect of ganciclovir therapy.
The Journal of infectious diseases 1988;158(6):1391-4.
1988: Jay A Berzofsky; Armand Bensussan; Kemp B Cease; J F Bourge; remi cheynier; Z Lurhuma; J J Salaün; Robert C Gallo; Gene M Shearer; Daniel Zagury
Antigenic peptides recognized by T lymphocytes from AIDS viral envelope-immune humans.
Nature 1988;334(6184):706-8.
1988: Charles S Via; J D Shanley; B R Weatherly; P Lang; Gene M Shearer
Altered threshold for the induction of graft-versus-host immunodeficiency following murine cytomegalovirus infection. Host and donor contributions.
Transplantation 1988;46(2):298-302.
1988: M Fukuzawa; Charles S Via; Gene M Shearer
Defective thymic education of L3T4+ T helper cell function in graft-vs-host mice.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(2):430-9.
1988: M Moser; Susan O Sharrow; Gene M Shearer
Role of L3T4+ and Lyt-2+ donor cells in graft-versus-host immune deficiency induced across a class I, class II, or whole H-2 difference.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(8):2600-8.
1988: Charles S Via; Gene M Shearer
Murine graft-versus-host disease as a model for the development of autoimmunity. Relevance of cytotoxic T lymphocytes.
Annals of the New York Academy of Sciences 1988;532():44-50.
1988: D C Bernstein; Gene M Shearer
Suppression of human cytotoxic T lymphocyte responses by adherent peripheral blood leukocytes.
Annals of the New York Academy of Sciences 1988;532():207-13.
1988: M Fukuzawa; Gene M Shearer
Effect of graft-versus-host reaction on thymic function.
Immunologic research 1988;7(3):239-46.
1987: J D Shanley; Charles S Via; S O Sharrow; Gene M Shearer
Interstitial pneumonitis during murine cytomegalovirus infection and graft-versus-host reaction. Characterization of bronchoalveolar lavage cells.
Transplantation 1987;44(5):658-62.