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Yoram Shechter

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Yoram Shechter; Vered Lev-Goldman; Sara Rubinraut; Menachem Rubinstein; Keren Sasson; Mati Fridkin
Newly designed modifier prolongs the action of short-lived peptides and proteins by allowing their binding to serum albumin.
Yoram Shechter; Vered Lev-Goldman; Yonit Marcus; Sara Rubinraut; Keren Sasson; Mati Fridkin
Establishing the principle of reversibility in peptide/protein and small-molecule therapy.
Gil Fridkin; Theodosia Maina; Berthold A Nock; Dan Blat; Vered Lev-Goldman; Yosef Scolnik; Aviva Kapitkovski; Yelena Vachutinsky; Yoram Shechter; Yaakov Levy
Intramolecular azo-bridge as a cystine disulfide bond surrogate: Somatostatin-14 and brain natriuretic peptide (BNP) analogs.

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All Publications

2012: Yoram Shechter; Vered Lev-Goldman; Sara Rubinraut; Menachem Rubinstein; Keren Sasson; Mati Fridkin
Newly designed modifier prolongs the action of short-lived peptides and proteins by allowing their binding to serum albumin.
Bioconjugate chemistry 2012;23(8):1577-86.
2012: Yoram Shechter; Vered Lev-Goldman; Yonit Marcus; Sara Rubinraut; Keren Sasson; Mati Fridkin
Establishing the principle of reversibility in peptide/protein and small-molecule therapy.
Therapeutic delivery 2012;3(1):17-23.
2011: Gil Fridkin; Theodosia Maina; Berthold A Nock; Dan Blat; Vered Lev-Goldman; Yosef Scolnik; Aviva Kapitkovski; Yelena Vachutinsky; Yoram Shechter; Yaakov Levy
Intramolecular azo-bridge as a cystine disulfide bond surrogate: Somatostatin-14 and brain natriuretic peptide (BNP) analogs.
Bioorganic & medicinal chemistry 2011;19(2):798-806.
2010: K Sasson; Y Marcus; V Lev-Goldman; Sara Rubinraut; M Fridkin; Yoram Shechter
Engineering prolonged-acting prodrugs employing an albumin-binding probe that undergoes slow hydrolysis at physiological conditions.
Journal of controlled release : official journal of the Controlled Release Society 2010;142(2):214-20.
2008: Yoram Shechter; Marina Mironchik; Sara Rubinraut; Haim Tsubery; K Sasson; Y Marcus; Mati Fridkin
Reversible pegylation of insulin facilitates its prolonged action in vivo.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;70(1):19-28.
2008: Yonit Marcus; Keren Sasson; Mati Fridkin; Yoram Shechter
Turning low-molecular-weight drugs into prolonged acting prodrugs by reversible pegylation: a study with gentamicin.
Journal of medicinal chemistry 2008;51(14):4300-5.
2005: Yoram Shechter; Marina Mironchik; Sara Rubinraut; Ayala Saul; Haim Tsubery; Mati Fridkin
Albumin-insulin conjugate releasing insulin slowly under physiological conditions: a new concept for long-acting insulin.
Bioconjugate chemistry 2005;16(4):913-20.
2005: Yoram Shechter; Haim Tsubery; Marina Mironchik; Menachem Rubinstein; Mati Fridkin
Reversible PEGylation of peptide YY3-36 prolongs its inhibition of food intake in mice.
FEBS letters 2005;579(11):2439-44.
2004: Tal Peleg-Shulman; Haim Tsubery; Marina Mironchik; Mati Fridkin; Gideon Schreiber; Yoram Shechter
Reversible PEGylation: a novel technology to release native interferon alpha2 over a prolonged time period.
Journal of medicinal chemistry 2004;47(20):4897-904.
2004: Haim Tsubery; Marina Mironchik; Mati Fridkin; Yoram Shechter
Prolonging the action of protein and peptide drugs by a novel approach of reversible polyethylene glycol modification.
The Journal of biological chemistry 2004;279(37):38118-24.
2003: Yoram Shechter; Haim Tsubery; Mati Fridkin
Suspensions of pro-drug insulin greatly prolong normoglycemic patterns in diabetic rats.
Biochemical and biophysical research communications 2003;307(2):315-21.
2003: Yoram Shechter; Haim Tsubery; Mati Fridkin
[2-Sulfo-9-fluorenylmethoxycarbonyl]3-exendin-4-a long-acting glucose-lowering prodrug.
Biochemical and biophysical research communications 2003;305(2):386-91.
2002: Yoram Shechter; Haim Tsubery; Mati Fridkin
N-[(2-Sulfo)-9-fluorenylmethoxycarbonyl](3)-gentamicin C(1) is a long-acting prodrug derivative.
Journal of medicinal chemistry 2002;45(19):4264-70.
2001: A Carter; Eldad J Dann; Tamar Katz; Yoram Shechter; Anna Oliven; Ronit Regev; E Eytan; Jacob M Rowe; Gera D Eytan
Cells from chronic myelogenous leukaemia patients at presentation exhibit multidrug resistance not mediated by either MDR1 or MRP1.
British journal of haematology 2001;114(3):581-90.
2001: Anna Oliven; Yoram Shechter
Extracorporeal photopheresis: a review.
Blood reviews 2001;15(2):103-8.
2001: Yoram Shechter; L Preciado-Patt; Gideon Schreiber; Mati Fridkin
Prolonging the half-life of human interferon-alpha 2 in circulation: Design, preparation, and analysis of (2-sulfo-9-fluorenylmethoxycarbonyl)7- interferon-alpha 2.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):1212-7.
2001: Daniella Magen; Anna Oliven; Yoram Shechter; Ronit Elhasid; Gad Bar-Joseph; Israel Zelikovic
Plasmapheresis in a very young infant with atypical hemolytic uremic syndrome.
Pediatric nephrology (Berlin, Germany) 2001;16(1):87-90.
2000: Ronit Elhasid; Myriam Weyl Ben Arush; Tamar Katz; Y Gan; Yoram Shechter; I Sami; Sergey Postovsky; Yair Reisner; Jacob M Rowe
Successful haploidentical bone marrow transplantation in Fanconi anemia.
Bone marrow transplantation 2000;26(11):1221-3.
2000: I Goldwaser; S Qian; E Gershonov; Mati Fridkin; Yoram Shechter
Organic vanadium chelators potentiate vanadium-evoked glucose metabolism in vitro and in vivo: establishing criteria for optimal chelators.
Molecular pharmacology 2000;58(4):738-46.
2000: Q Sun; N Sekar; I Goldwaser; E Gershonov; Mati Fridkin; Yoram Shechter
Vanadate restores glucose 6-phosphate in diabetic rats: a mechanism to enhance glucose metabolism.
American journal of physiology. Endocrinology and metabolism 2000;279(2):E403-10.
2000: E Gershonov; I Goldwaser; Mati Fridkin; Yoram Shechter
A novel approach for a water-soluble long-acting insulin prodrug: design, preparation, and analysis of [(2-sulfo)-9-fluorenylmethoxycarbonyl](3)-insulin.
Journal of medicinal chemistry 2000;43(13):2530-7.
2000: I Goldwaser; D Gefel; E Gershonov; Mati Fridkin; Yoram Shechter
Insulin-like effects of vanadium: basic and clinical implications.
Journal of inorganic biochemistry 2000;80(1-2):21-5.
1999: I Goldwaser; J Li; E Gershonov; Michal Armoni; Eddy Karnieli; Mati Fridkin; Yoram Shechter
L-Glutamic acid gamma-monohydroxamate. A potentiator of vanadium-evoked glucose metabolism in vitro and in vivo.
The Journal of biological chemistry 1999;274(37):26617-24.
1999: E Gershonov; Yoram Shechter; Mati Fridkin
New concept for long-acting insulin: spontaneous conversion of an inactive modified insulin to the active hormone in circulation: 9-fluorenylmethoxycarbonyl derivative of insulin.
Diabetes 1999;48(7):1437-42.
1999: N Sekar; J Li; Z He; D Gefel; Yoram Shechter
Independent signal-transduction pathways for vanadate and for insulin in the activation of glycogen synthase and glycogenesis in rat adipocytes.
Endocrinology 1999;140(3):1125-31.
1998: Yoram Shechter; Y Tal; A Greenberg; Benjamin Brenner
Platelet activation in patients with antiphospholipid syndrome.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1998;9(7):653-7.
1998: Benjamin Dekel; Hadar Marcus; B Shenkman; A Shimoni; Yoram Shechter; A Canaan; Alain Berrebi; D Varon; Yair Reisner
Human/BALB radiation chimera engrafted with splenocytes from patients with idiopathic thrombocytopenic purpura produce human platelet antibodies.
Immunology 1998;94(3):410-6.
1998: Naomi Lanir; M Zilberman; I Yron; G Tennenbaum; Yoram Shechter; Benjamin Brenner
Reactivity patterns of antiphospholipid antibodies and endothelial cells: effect of antiendothelial antibodies on cell migration.
The Journal of laboratory and clinical medicine 1998;131(6):548-56.
1998: N Sekar; S Qian; Yoram Shechter
Vanadate elevates lipogenicity of starved rat adipose tissue: mechanism of action.
Endocrinology 1998;139(5):2514-8.
1997: N Sekar; J Li; Z bin He; Yoram Shechter
A novel assay for evaluating glycogenolysis in rat adipocytes and the inability of insulin to antagonize glycogenolysis in this cell type.
Biochemistry 1997;36(51):16206-11.
1997: G Elberg; Z He; J Li; N Sekar; Yoram Shechter
Vanadate activates membranous nonreceptor protein tyrosine kinase in rat adipocytes.
Diabetes 1997;46(11):1684-90.
1997: J Li; G Elberg; N Sekar; Z bin He; Yoram Shechter
Antilipolytic actions of vanadate and insulin in rat adipocytes mediated by distinctly different mechanisms.
Endocrinology 1997;138(6):2274-9.
1996: N Sekar; J Li; Yoram Shechter
Vanadium salts as insulin substitutes: mechanisms of action, a scientific and therapeutic tool in diabetes mellitus research.
Critical reviews in biochemistry and molecular biology 1996;31(5-6):339-59.
1996: J Li; G Elberg; Yoram Shechter
Phenylarsine oxide and vanadate: apparent paradox of inhibition of protein phosphotyrosine phosphatases in rat adipocytes.
Biochimica et biophysica acta 1996;1312(3):223-30.
1996: J Li; G Elberg; D C Crans; Yoram Shechter
Evidence for the distinct vanadyl(+4)-dependent activating system for manifesting insulin-like effects.
Biochemistry 1996;35(25):8314-8.
1996: G Elberg; M J Rapoport; D Vashdi-Elberg; Arieh Gertler; Yoram Shechter
Lactogenic hormones rapidly activate p21( ras )/mitogen-activated protein kinase in Nb2-11C rat lymphoma cells.
Endocrine 1996;4(1):65-71.
1995: Yoram Shechter; J Li; J Meyerovitch; D Gefel; Rafael Bruck; G Elberg; D S Miller; Assia Shisheva
Insulin-like actions of vanadate are mediated in an insulin-receptor-independent manner via non-receptor protein tyrosine kinases and protein phosphotyrosine phosphatases.
Molecular and cellular biochemistry 1995;153(1-2):39-47.
1995: G Elberg; J Li; A Leibovitch; Yoram Shechter
Non-receptor cytosolic protein tyrosine kinases from various rat tissues.
Biochimica et biophysica acta 1995;1269(3):299-306.
1995: J Li; G Elberg; J Libman; Abraham Shanzer; D Cefel; Yoram Shechter
Insulin-like effects of tungstate and molybdate: mediation through insulin receptor independent pathways.
Endocrine 1995;3(9):631-7.
1995: J Li; G Elberg; D Gefel; Yoram Shechter
Permolybdate and pertungstate--potent stimulators of insulin effects in rat adipocytes: mechanism of action.
Biochemistry 1995;34(18):6218-25.
1994: Assia Shisheva; Yoram Shechter
A dynamic system for suppression and re-expression of insulin and pervanadate bioresponses in rat adipocytes. Treatment with okadaic acid and staurosporine.
Biochemical pharmacology 1994;47(9):1537-44.
1994: G Elberg; J Li; Yoram Shechter
Vanadium activates or inhibits receptor and non-receptor protein tyrosine kinases in cell-free experiments, depending on its oxidation state. Possible role of endogenous vanadium in controlling cellular protein tyrosine kinase activity.
The Journal of biological chemistry 1994;269(13):9521-7.
1994: Assia Shisheva; Ognian C Ikonomov; Yoram Shechter
The protein tyrosine phosphatase inhibitor, pervanadate, is a powerful antidiabetic agent in streptozotocin-treated diabetic rats.
Endocrinology 1994;134(1):507-10.
1993: Assia Shisheva; Yoram Shechter
Mechanism of pervanadate stimulation and potentiation of insulin-activated glucose transport in rat adipocytes: dissociation from vanadate effect.
Endocrinology 1993;133(4):1562-8.
1993: Assia Shisheva; Yoram Shechter
Role of cytosolic tyrosine kinase in mediating insulin-like actions of vanadate in rat adipocytes.
The Journal of biological chemistry 1993;268(9):6463-9.
1993: Yoram Shechter; Assia Shisheva
Vanadium salts and the future treatment of diabetes.
Endeavour 1993;17(1):27-31.
1992: Assia Shisheva; Yoram Shechter
Quercetin selectively inhibits insulin receptor function in vitro and the bioresponses of insulin and insulinomimetic agents in rat adipocytes.
Biochemistry 1992;31(34):8059-63.
1992: Assia Shisheva; D Gefel; Yoram Shechter
Insulinlike effects of zinc ion in vitro and in vivo. Preferential effects on desensitized adipocytes and induction of normoglycemia in streptozocin-induced rats.
Diabetes 1992;41(8):982-8.
1992: Assia Shisheva; Yoram Shechter
A cytosolic protein tyrosine kinase in rat adipocytes.
FEBS letters 1992;300(1):93-6.
1992: Yoram Shechter; Assia Shisheva; R Lazar; J Libman; Abraham Shanzer
Hydrophobic carriers of vanadyl ions augment the insulinomimetic actions of vanadyl ions in rat adipocytes.
Biochemistry 1992;31(7):2063-8.
1991: Assia Shisheva; O Leitner; Yoram Shechter
A novel approach for evaluating tyrosine kinase activity based on the radioimmunological determination of phosphotyrosine.
Journal of biochemical and biophysical methods 1991;23(4):307-14.
1991: Assia Shisheva; Yoram Shechter
Effect of okadaic acid in rat adipocytes: differential stimulation of glucose and lipid metabolism and induction of refractoriness to insulin and vanadate.
Endocrinology 1991;129(5):2279-88.
1991: Rafael Bruck; H Prigozin; Z Krepel; P Rotenberg; Yoram Shechter; Simon Bar-Meir
Vanadate inhibits glucose output from isolated perfused rat liver.
Hepatology (Baltimore, Md.) 1991;14(3):540-4.
1991: J Meyerovitch; P Rothenberg; Yoram Shechter; Susan Bonner-Weir; C Ronald Kahn
Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1991;87(4):1286-94.
1990: J Meyerovitch; C Ronald Kahn; Yoram Shechter
A family of polypeptide substrates and inhibitors of insulin receptor kinase.
Biochemistry 1990;29(15):3654-60.
1990: Yoram Shechter
Insulin-mimetic effects of vanadate. Possible implications for future treatment of diabetes.
Diabetes 1990;39(1):1-5.
1989: J Meyerovitch; Yoram Shechter; Shimon Amir
Vanadate stimulates in vivo glucose uptake in brain and arrests food intake and body weight gain in rats.
Physiology & behavior 1989;45(6):1113-6.
1989: Yoram Shechter; P Yaish; M Chorev; Chaim Gilon; S Braun; Alexander Levitzki
Inhibition of insulin-dependent lipogenesis and anti-lipolysis by protein tyrosine kinase inhibitors.
The EMBO journal 1989;8(6):1671-6.
1988: D Elias; M Rapoport; Irun R Cohen; Yoram Shechter
Desensitization of the insulin receptor by antireceptor antibodies in vivo is blocked by treatment of mice with beta-adrenergic agonists.
The Journal of clinical investigation 1988;81(6):1979-85.
1988: Shimon Amir; Yoram Shechter
Apparent involvement of protein kinase C in the central glucoregulatory action of insulin.
Brain research 1988;450(1-2):272-9.
1988: Yoram Shechter; J Meyerovitch; Shimon Amir
The use of post-binding agents in studying insulin action and its relation to experimental diabetes.
Biochemical pharmacology 1988;37(10):1891-6.
1987: Shimon Amir; J Meyerovitch; Yoram Shechter
Vanadate ions: central nervous system action on glucoregulation.
Brain research 1987;419(1-2):392-6.
1987: Shimon Amir; Yoram Shechter
Centrally mediated hypoglycemic effect of insulin: apparent involvement of specific insulin receptors.
Brain research 1987;418(1):152-6.
1987: Shimon Amir; Shlomo Sasson; Nurit Kaiser; J Meyerovitch; Yoram Shechter
Polymyxin B is an inhibitor of insulin-induced hypoglycemia in the whole animal model. Studies on the mode of inhibitory action.
The Journal of biological chemistry 1987;262(14):6663-7.
1987: J Meyerovitch; Z Farfel; J Sack; Yoram Shechter
Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats. Characterization and mode of action.
The Journal of biological chemistry 1987;262(14):6658-62.