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Douglas Sheffler

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Chemicals & Drugs

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Cells, Cultured

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Publications

TOP 3
Ryan T Strachan; John A Allen; Douglas J Sheffler; Bryan L Roth
p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling.
Ryan T Strachan; Douglas J Sheffler; Belinda B Willard; Michael Kinter; Janna G Kiselar; Bryan L Roth
Ribosomal S6 kinase 2 directly phosphorylates the 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor, thereby modulating 5-HT2A signaling.
Douglas J Sheffler; Wesley K Kroeze; Bonnie G Garcia; Ariel Deutch; Sandra J Hufeisen; Patrick Leahy; Jens C Brüning; Bryan L Roth
p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling.

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All Publications

2010: Ryan T Strachan; John A Allen; Douglas J Sheffler; Bryan L Roth
p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling.
Biochemistry 2010;49(12):2657-71.
2009: Ryan T Strachan; Douglas J Sheffler; Belinda B Willard; Michael Kinter; Janna G Kiselar; Bryan L Roth
Ribosomal S6 kinase 2 directly phosphorylates the 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor, thereby modulating 5-HT2A signaling.
The Journal of biological chemistry 2009;284(9):5557-73.
2006: Douglas J Sheffler; Wesley K Kroeze; Bonnie G Garcia; Ariel Deutch; Sandra J Hufeisen; Patrick Leahy; Jens C Brüning; Bryan L Roth
p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4717-22.
2006: Marilyn A Davies; Vincent Setola; R T Strachan; Douglas J Sheffler; E Salay; Sandra J Hufeisen; Bryan L Roth
Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies.
The pharmacogenomics journal 2006;6(1):42-51.
2005: Feng Yan; Philip D Mosier; Richard B Westkaemper; Jeremy Stewart; Jordan K Zjawiony; Timothy A Vortherms; Douglas J Sheffler; Bryan L Roth
Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors.
Biochemistry 2005;44(24):8643-51.
2004: Anushree Bhatnagar; Douglas J Sheffler; Wesley K Kroeze; Beth A Compton-Toth; Bryan L Roth
Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors.
The Journal of biological chemistry 2004;279(33):34614-23.
2004: Bryan L Roth; Douglas J Sheffler; Wesley K Kroeze
Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia.
Nature reviews. Drug discovery 2004;3(4):353-9.
2004: Marilyn A Davies; Douglas J Sheffler; Bryan L Roth
Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology.
CNS drug reviews 2004;10(4):317-36.
2003: Wesley K Kroeze; Douglas J Sheffler; Bryan L Roth
G-protein-coupled receptors at a glance.
Journal of cell science 2003;116(Pt 24):4867-9.
2003: Douglas J Sheffler; Bryan L Roth
Salvinorin A: the "magic mint" hallucinogen finds a molecular target in the kappa opioid receptor.
Trends in pharmacological sciences 2003;24(3):107-9.
2001: John A Gray; Douglas J Sheffler; Anushree Bhatnagar; J A Woods; Sandra J Hufeisen; JL Benovic; Bryan L Roth
Cell-type specific effects of endocytosis inhibitors on 5-hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells.
Molecular pharmacology 2001;60(5):1020-30.