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Søren Sheikh

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Signal Transduction

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Ditte C Andersen; Charlotte H Jensen; Charlotte Nielsen; Søren P Sheikh
Horse serum reduces expression of membrane-bound and soluble isoforms of the preadipocyte marker Delta-like 1 homolog (Dlk1), but is inefficient for adipogenic differentiation of mouse preadipocytes.
Jonas Tind Hansen; Pernille B L Hansen; Christina Lyngsø; Søren P Sheikh; Tobias Speerschneider; David M Weiner; Ethan S Burstein; Celine Gales; Jakob Lerche Hansen
Functional enhancement of AT1R potency in the presence of the TPαR is revealed by a comprehensive 7TM receptor co-expression screen.
Sussi B Mortensen; Mikael Schneider; Søren P Sheikh; Mads Thomassen; Charlotte H Jensen; Torben A Kruse; Jorge Laborda; Ditte C Andersen
Membrane-tethered delta-like 1 homolog (DLK1) restricts adipose tissue size by inhibiting preadipocyte proliferation.

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2013: Ditte C Andersen; Charlotte H Jensen; Charlotte Nielsen; Søren P Sheikh
Horse serum reduces expression of membrane-bound and soluble isoforms of the preadipocyte marker Delta-like 1 homolog (Dlk1), but is inefficient for adipogenic differentiation of mouse preadipocytes.
Acta histochemica 2013;115(4):401-6.
2013: Jonas Tind Hansen; Pernille B L Hansen; Christina Lyngsø; Søren P Sheikh; Tobias Speerschneider; David M Weiner; Ethan S Burstein; Celine Gales; Jakob Lerche Hansen
Functional enhancement of AT1R potency in the presence of the TPαR is revealed by a comprehensive 7TM receptor co-expression screen.
PloS one 2013;8(3):e58890.
2012: Sussi B Mortensen; Mikael Schneider; Søren P Sheikh; Mads Thomassen; Charlotte H Jensen; Torben A Kruse; Jorge Laborda; Ditte C Andersen
Membrane-tethered delta-like 1 homolog (DLK1) restricts adipose tissue size by inhibiting preadipocyte proliferation.
Diabetes 2012;61(11):2814-22.
2011: Marie Mi Bonde; Kristine Boisen Olsen; Niels Erikstrup; Tobias Speerschneider; Christina Lyngsø; Stig Haunsø; Morten Schak Nielsen; Søren P Sheikh; Jakob Lerche Hansen
The angiotensin II type 1 receptor antagonist Losartan binds and activates bradykinin B2 receptor signaling.
Regulatory peptides 2011;167(1):21-5.
2011: Gitte L Christensen; Steen Knudsen; Mikael Schneider; Mark Aplin; Steen Gammeltoft; Søren P Sheikh; Jakob L Hansen
AT(1) receptor Gαq protein-independent signalling transcriptionally activates only a few genes directly, but robustly potentiates gene regulation from the β2-adrenergic receptor.
Molecular and cellular endocrinology 2011;331(1):49-56.
2010: Marie Mi Bonde; Rong Yao; Jian-Nong Ma; Srinivasan Madabushi; Stig Haunsø; Ethan S Burstein; Jennifer L Whistler; Søren P Sheikh; Olivier Lichtarge; Jakob Lerche Hansen
An angiotensin II type 1 receptor activation switch patch revealed through evolutionary trace analysis.
Biochemical pharmacology 2010;80(1):86-94.
2010: Ditte C Andersen; Charlotte H Jensen; Mikael Schneider; Anne Yaël Nossent; Tilde Eskildsen; Jakob L Hansen; Børge Teisner; Søren P Sheikh
MicroRNA-15a fine-tunes the level of Delta-like 1 homolog (DLK1) in proliferating 3T3-L1 preadipocytes.
Experimental cell research 2010;316(10):1681-91.
2009: Jakob L Hansen; Jonas T Hansen; Tobias Speerschneider; Christina Lyngsø; Niels Erikstrup; Ethan S Burstein; David M Weiner; Thomas Walther; Noriko Makita; Taroh Iiri; Nicole Merten; Evi Kostenis; Søren P Sheikh
Lack of evidence for AT1R/B2R heterodimerization in COS-7, HEK293, and NIH3T3 cells: how common is the AT1R/B2R heterodimer?
The Journal of biological chemistry 2009;284(3):1831-9.
2008: Jakob Lerche Hansen; Mark Aplin; Jonas Tind Hansen; Gitte Lund Christensen; Marie Mi Bonde; Mikael Schneider; Stig Haunsø; Hans H Schiffer; Ethan S Burstein; David M Weiner; Søren P Sheikh
The human angiotensin AT(1) receptor supports G protein-independent extracellular signal-regulated kinase 1/2 activation and cellular proliferation.
European journal of pharmacology 2008;590(1-3):255-63.
2008: Mikael Schneider; Jakob L Hansen; Søren P Sheikh
S100A4: a common mediator of epithelial-mesenchymal transition, fibrosis and regeneration in diseases?
Journal of molecular medicine (Berlin, Germany) 2008;86(5):507-22.
2007: Mikael Schneider; Sawa Kostin; Claes C Strøm; Mark Aplin; Stig Lyngbaek; Juliane Theilade; Mariam Grigorian; Claus B Andersen; Eugene Lukanidin; Jakob Lerche Hansen; Søren P Sheikh
S100A4 is upregulated in injured myocardium and promotes growth and survival of cardiac myocytes.
Cardiovascular research 2007;75(1):40-50.
2007: Mark Aplin; Gitte Lund Christensen; Mikael Schneider; Arne Heydorn; Steen Gammeltoft; Anne Louise Kjølbye; Søren P Sheikh; Jakob Lerche Hansen
Differential extracellular signal-regulated kinases 1 and 2 activation by the angiotensin type 1 receptor supports distinct phenotypes of cardiac myocytes.
Basic & clinical pharmacology & toxicology 2007;100(5):296-301.
2007: Mark Aplin; Gitte Lund Christensen; Mikael Schneider; Arne Heydorn; Steen Gammeltoft; Anne Louise Kjølbye; Søren P Sheikh; Jakob Lerche Hansen
The angiotensin type 1 receptor activates extracellular signal-regulated kinases 1 and 2 by G protein-dependent and -independent pathways in cardiac myocytes and langendorff-perfused hearts.
Basic & clinical pharmacology & toxicology 2007;100(5):289-95.
2007: Stig Lyngbaek; Mikael Schneider; Jakob Lerche Hansen; Søren P Sheikh
Cardiac regeneration by resident stem and progenitor cells in the adult heart.
Basic research in cardiology 2007;102(2):101-14.
2006: manda krishnaveni; Jakob Lerche Hansen; Werner Seeger; Rory Morty; Søren P Sheikh; Oliver Eickelberg
Constitutive homo- and hetero-oligomerization of TbetaRII-B, an alternatively spliced variant of the mouse TGF-beta type II receptor.
Biochemical and biophysical research communications 2006;351(3):651-7.
2006: Sanela Smajilovic; Jakob Lerche Hansen; Tue E H Christoffersen; Ewa Lewin; Søren P Sheikh; Ernest Terwilliger; Edward M Brown; Stig Haunso; Jacob Tfelt-Hansen
Extracellular calcium sensing in rat aortic vascular smooth muscle cells.
Biochemical and biophysical research communications 2006;348(4):1215-23.
2006: Jakob Lerche Hansen; Juliane Theilade; Mark Aplin; Søren P Sheikh
Role of G-protein-coupled receptor kinase 2 in the heart--do regulatory mechanisms open novel therapeutic perspectives?
Trends in cardiovascular medicine 2006;16(5):169-77.
2006: Tue E H Christoffersen; Mark Aplin; Claes C Strom; Søren P Sheikh; Ole Skott; Peter K Busk; Stig Haunso; Lars B Nielsen
Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy.
American journal of physiology. Heart and circulatory physiology 2006;290(4):H1635-41.
2006: Marie Mi Bonde; Søren P Sheikh; Jakob Lerche Hansen
Family C 7TM receptor dimerization and activation.
Endocrine, metabolic & immune disorders drug targets 2006;6(1):7-16.
2006: Jacob Tfelt-Hansen; Jakob Lerche Hansen; Sanela Smajilovic; Ernest Terwilliger; Stig Haunso; Søren P Sheikh
Calcium receptor is functionally expressed in rat neonatal ventricular cardiomyocytes.
American journal of physiology. Heart and circulatory physiology 2006;290(3):H1165-71.
2005: Claes C Strøm; Mark Aplin; Thorkil Ploug; Tue E H Christoffersen; Jozef Langfort; Michael Viese; Henrik Galbo; Stig Haunsø; Søren P Sheikh
Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy.
The FEBS journal 2005;272(11):2684-95.
2005: Juliane Theilade; Jakob Lerche Hansen; Stig Haunsø; Søren P Sheikh
MAP kinase protects G protein-coupled receptor kinase 2 from proteasomal degradation.
Biochemical and biophysical research communications 2005;330(3):685-9.
2004: Jakob Lerche Hansen; Søren P Sheikh
Functional consequences of 7TM receptor dimerization.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;23(4-5):301-17.
2004: Juliane Theilade; Stig Haunsø; Søren P Sheikh
[G receptor kinases. A family of "natural" receptor blockers].
Ugeskrift for laeger 2004;166(45):4026-30.
2004: Jakob Lerche Hansen; Juliane Theilade; Stig Haunsø; Søren P Sheikh
Oligomerization of wild type and nonfunctional mutant angiotensin II type I receptors inhibits galphaq protein signaling but not ERK activation.
The Journal of biological chemistry 2004;279(23):24108-15.
2004: Jakob Lerche Hansen; Stig Haunsø; Mark R Brann; Søren P Sheikh; David M Weiner
Loss-of-function polymorphic variants of the human angiotensin II type 1 receptor.
Molecular pharmacology 2004;65(3):770-7.
2004: Claes C Strøm; Mogens Kruhøffer; Steen Knudsen; Frank Stensgaard-Hansen; Thomas E N Jonassen; Torben F Orntoft; Stig Haunsø; Søren P Sheikh
Identification of a core set of genes that signifies pathways underlying cardiac hypertrophy.
Comparative and functional genomics 2004;5(6-7):459-70.
2003: Peter K Busk; Linda Wulf-Andersen; Claes C Strøm; Micha Enevoldsen; Kenneth Thirstrup; Stig Haunsø; Søren P Sheikh
Multiprotein bridging factor 1 cooperates with c-Jun and is necessary for cardiac hypertrophy in vitro.
Experimental cell research 2003;286(1):102-14.
2003: Juliane Theilade; Claes C Strøm; T Christiansen; Stig Haunsø; Søren P Sheikh
Differential G protein receptor kinase 2 expression in compensated hypertrophy and heart failure after myocardial infarction in the rat.
Basic research in cardiology 2003;98(2):97-103.
2002: Anders A Jensen; Jakob Lerche Hansen; Søren P Sheikh; Hans Bräuner-Osborne
Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET).
European journal of biochemistry / FEBS 2002;269(20):5076-87.
2002: Peter K Busk; Jirina Bartkova; Claes C Strøm; Linda Wulf-Andersen; Rebecca Hinrichsen; Tue E H Christoffersen; Lucia Latella; Jiri Bartek; Stig Haunsø; Søren P Sheikh
Involvement of cyclin D activity in left ventricle hypertrophy in vivo and in vitro.
Cardiovascular research 2002;56(1):64-75.
2002: Juliane Theilade; Jakob Lerche Hansen; Stig Haunsø; Søren P Sheikh
Extracellular signal-regulated kinases control expression of G protein-coupled receptor kinase 2 (GRK2).
FEBS letters 2002;518(1-3):195-9.
2001: Juliane Theilade; Stig Haunsø; Søren P Sheikh
G protein-coupled receptor kinase 2--a feedback regulator of Gq pathway signalling.
Current drug targets. Immune, endocrine and metabolic disorders 2001;1(2):139-51.
2000: Søren P Sheikh; Stig Haunsø
[Small progress on the long journey to gene therapy of chronic ischemic heart disease].
Ugeskrift for laeger 2000;162(49):6694-5.
2000: Jakob Lerche Hansen; Guy Servant; Thomas J Baranski; T Fujita; Taroh Iiri; Søren P Sheikh
Functional reconstitution of the angiotensin II type 2 receptor and G(i) activation.
Circulation research 2000;87(9):753-9.
1999: Søren P Sheikh; J P Vilardarga; Thomas J Baranski; Olivier Lichtarge; Taroh Iiri; Elaine C Meng; Robert A Nissenson; Henry R Bourne
Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation.
The Journal of biological chemistry 1999;274(24):17033-41.
1999: Thomas J Baranski; Paul Herzmark; Olivier Lichtarge; Basil O Gerber; J Trueheart; Elaine C Meng; Taroh Iiri; Søren P Sheikh; Henry R Bourne
C5a receptor activation. Genetic identification of critical residues in four transmembrane helices.
The Journal of biological chemistry 1999;274(22):15757-65.
1998: Søren P Sheikh; N Feldthus; H Orkild; Rüdiger Göke; Gerard P McGregor; David L Turner; Morten Møller; Edward L Stuenkel
Neuropeptide Y2 receptors on nerve endings from the rat neurohypophysis regulate vasopressin and oxytocin release.
Neuroscience 1998;82(1):107-15.
1997: Søren P Sheikh; J Carisen; Peter Riis Hansen; Stig Haunsø
[Molecular biology and cardiology. Molecular mechanisms in heart failure].
Ugeskrift for laeger 1997;159(17):2523-8.
1996: W Yao; Søren P Sheikh; Bent Ottesen; J C Jørgensen
The effect of neuropeptides on vessel tone and cAMP production.
Annals of the New York Academy of Sciences 1996;805():784-8.
1996: Mads Tang-Christensen; Philip J Larsen; Rüdiger Göke; Anders Fink-Jensen; David S Jessop; M Møller; Søren P Sheikh
Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats.
The American journal of physiology 1996;271(4 Pt 2):R848-56.
1996: Søren P Sheikh; T A Zvyaga; Olivier Lichtarge; Thomas P Sakmar; Henry R Bourne
Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F.
Nature 1996;383(6598):347-50.
1996: W Yao; Søren P Sheikh; Bent Ottesen; J C Jørgensen
Vascular effects and cyclic AMP production produced by VIP, PHM, PHV, PACAP-27, PACAP-38, and NPY on rabbit ovarian artery.
Peptides 1996;17(5):809-15.
1995: Rüdiger Göke; Philip J Larsen; Jens D Mikkelsen; Søren P Sheikh
Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites.
The European journal of neuroscience 1995;7(11):2294-300.
1995: Rüdiger Göke; Philip J Larsen; Jens D Mikkelsen; Søren P Sheikh
Identification of specific binding sites for glucagon-like peptide-1 on the posterior lobe of the rat pituitary.
Neuroendocrinology 1995;62(2):130-4.
1995: C Freitag; A B Svendsen; N Feldthus; K Løssl; Søren P Sheikh
Coupling of the human Y2 receptor for neuropeptide Y and peptide YY to guanine nucleotide inhibitory proteins in permeabilized SMS-KAN cells.
Journal of neurochemistry 1995;64(2):643-50.
1995: Philip J Larsen; Søren P Sheikh; Jens D Mikkelsen
Neuropeptide Y Y1 receptors in the rat forebrain: autoradiographic demonstration of [125I][Leu31,Pro34]-NPY binding sites and neurons expressing Y1 receptor mRNA.
Journal of receptor and signal transduction research 1995;15(1-4):457-72.
1994: André Wettergren; H Petersen; Cathrine Orskov; John Christiansen; Søren P Sheikh; J J Holst
Glucagon-like peptide-1 7-36 amide and peptide YY from the L-cell of the ileal mucosa are potent inhibitors of vagally induced gastric acid secretion in man.
Scandinavian journal of gastroenterology 1994;29(6):501-5.
1992: A P Hansen; Søren P Sheikh
Y2 receptor proteins for peptide YY and neuropeptide Y. Characterization as N-linked complex glycoproteins.
FEBS letters 1992;306(2-3):147-50.
1992: Rüdiger Göke; B Oltmer; Søren P Sheikh; Burkhard Göke
Solubilization of active GLP-1 (7-36)amide receptors from RINm5F plasma membranes.
FEBS letters 1992;300(3):232-6.
1992: Jens D Mikkelsen; P Schmidt; Søren P Sheikh; Philip J Larsen
Non-vasopressinergic, non-oxytocinergic neuropeptides in the rat hypothalamo-neurohypophyseal tract: experimental immunohistochemical studies.
Progress in brain research 1992;91():367-71.
1991: Søren P Sheikh; A P Hansen; John Williams
Solubilization and affinity purification of the Y2 receptor for neuropeptide Y and peptide YY from rabbit kidney.
The Journal of biological chemistry 1991;266(35):23959-66.
1991: Søren P Sheikh
Neuropeptide Y and peptide YY: major modulators of gastrointestinal blood flow and function.
The American journal of physiology 1991;261(5 Pt 1):G701-15.
1991: Søren Nielsen; Søren P Sheikh; M I Sheikh; Erik I Christensen
Peptide YY luminal processing and axial heterogeneity of basolateral binding in renal proximal tubules.
The American journal of physiology 1991;260(3 Pt 2):F359-67.
1990: J H Svendsen; Søren P Sheikh; J Jørgensen; J D Mikkelsen; W P Paaske; P Sejrsen; Stig Haunsø
Effects of neuropeptide Y on regulation of blood flow rate in canine myocardium.
The American journal of physiology 1990;259(6 Pt 2):H1709-17.
1989: Søren P Sheikh; J J Holst; Cathrine Orskov; R Ekman; Thue W Schwartz
Release of PYY from pig intestinal mucosa; luminal and neural regulation.
Regulatory peptides 1989;26(3):253-66.
1989: Søren P Sheikh; M I Sheikh; Thue W Schwartz
Y2-type receptors for peptide YY on renal proximal tubular cells in the rabbit.
The American journal of physiology 1989;257(6 Pt 2):F978-84.
1989: J C Jørgensen; Søren P Sheikh; Axel Forman; M Nørgård; Thue W Schwartz; Bent Ottesen
Neuropeptide Y in the human female genital tract: localization and biological action.
The American journal of physiology 1989;257(2 Pt 1):E220-7.
1989: Michael Busch-Sørensen; Søren P Sheikh; M O'Hare; O Tortora; Thue W Schwartz; Steen Gammeltoft
Regional distribution of neuropeptide Y and its receptor in the porcine central nervous system.
Journal of neurochemistry 1989;52(5):1545-52.
1989: Søren P Sheikh; M M O'Hare; O Tortora; Thue W Schwartz
Binding of monoiodinated neuropeptide Y to hippocampal membranes and human neuroblastoma cell lines.
The Journal of biological chemistry 1989;264(12):6648-54.
1989: Søren P Sheikh; R Håkanson; Thue W Schwartz
Y1 and Y2 receptors for neuropeptide Y.
FEBS letters 1989;245(1-2):209-14.
1988: Søren P Sheikh; Jens Juul Holst; T Skak-Nielsen; U Knigge; Jørgen Warberg; E Theodorsson-Norheim; T Hökfelt; J M Lundberg; Thue W Schwartz
Release of NPY in pig pancreas: dual parasympathetic and sympathetic regulation.
The American journal of physiology 1988;255(1 Pt 1):G46-54.
1987: Thue W Schwartz; Søren P Sheikh; M M O'Hare
Receptors on phaeochromocytoma cells for two members of the PP-fold family--NPY and PP.
FEBS letters 1987;225(1-2):209-14.