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Beifen Shen

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Chunxia Qiao; Jiyan Zhang; Jiannan Feng; Jing Geng; Xinying Li; Yan Li; Zhou Lin; Ming Lv; Beifen Shen
Affinity maturation of antiHER2 monoclonal antibody MIL5 using an epitope-specific synthetic phage library by computational design.
Xiaomei Yang; Tingting Zhou; Guojiang Chen; Jiannan Feng; Shaoxia Geng; Xiaoqin Guo; Chunmei Hou; Xingwei Jiang; Chunyan Kang; Xinying Li; Yurong Li; Yan Li; Zhou Lin; Yuanfang Ma; Beifen Shen; Renxi Wang; He Xiao; Yan Xiao; Gencheng Han
T cell Ig mucin-3 promotes homeostasis of sepsis by negatively regulating the TLR response.
Yuanyuan Guo; Jianfeng Jin; Xinying Li; Yan Li; Ming Lv; Yuanfang Ma; Beifen Shen; Jing Wang; Qingyang Wang; Wendie Wang; Jiannan Feng; Jiyan Zhang
Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity.

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2013: Chunxia Qiao; Jiyan Zhang; Jiannan Feng; Jing Geng; Xinying Li; Yan Li; Zhou Lin; Ming Lv; Beifen Shen
Affinity maturation of antiHER2 monoclonal antibody MIL5 using an epitope-specific synthetic phage library by computational design.
Journal of biomolecular structure & dynamics 2013;31(5):511-21.
2013: Xiaomei Yang; Tingting Zhou; Guojiang Chen; Jiannan Feng; Shaoxia Geng; Xiaoqin Guo; Chunmei Hou; Xingwei Jiang; Chunyan Kang; Xinying Li; Yurong Li; Yan Li; Zhou Lin; Yuanfang Ma; Beifen Shen; Renxi Wang; He Xiao; Yan Xiao; Gencheng Han
T cell Ig mucin-3 promotes homeostasis of sepsis by negatively regulating the TLR response.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(5):2068-79.
2013: Yuanyuan Guo; Jianfeng Jin; Xinying Li; Yan Li; Ming Lv; Yuanfang Ma; Beifen Shen; Jing Wang; Qingyang Wang; Wendie Wang; Jiannan Feng; Jiyan Zhang
Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity.
Hepatology (Baltimore, Md.) 2013;57(1):140-51.
2012: Fengmin Shi; Renxi Wang; He Xiao; Yan Xiao; Xiaomei Yang; Zhi Zhao; Ping Zhou; Tingting Zhou; Guojiang Chen; Jiannan Feng; Xiaoqin Guo; Chunmei Hou; Xingwei Jiang; Xinying Li; Yan Li; Beifen Shen; Gencheng Han
Dysregulated Tim-3 expression and its correlation with imbalanced CD4 helper T cell function in ulcerative colitis.
Clinical immunology (Orlando, Fla.) 2012;145(3):230-40.
2012: Ming Lv; Chunxia Qiao; Ming Yu; Jiannan Feng; Chunmei Hou; Nan Jiang; Xinying Li; Yan Li; Beifen Shen
The peptide derived from erbB2 auto-inhibitor herstatin shared in the same epitope and function with functional antibody 2C4.
Molecular biotechnology 2012;51(2):174-82.
2012: Xiangrui Guo; Yuanyuan Guo; Yajing Li; Yan Li; Beifen Shen; Dejun Sun; Jing Wang; Xueying Zhang; Jiyan Zhang
Nocodazole increases the ERK activity to enhance MKP-1expression which inhibits p38 activation induced by TNF-α.
Molecular and cellular biochemistry 2012;364(1-2):373-80.
2012: Changguo Chen; Liang Guo; Ming Hu; Meiru Hu; Lu Qian; Beifen Shen; Ming Shi; Lun Song; Tianyou Wang; Ming Yu; Ning Guo
Modulation of IFN-γ receptor 1 expression by AP-2α influences IFN-γ sensitivity of cancer cells.
The American journal of pathology 2012;180(2):661-71.
2012: Ke Wang; Renxi Wang; Yi Wang; He Xiao; Yan Dou; Renfeng Guo; Gencheng Han; Chunmei Hou; Xinying Li; Yan Li; Guijun Liu; Beifen Shen; Yanchun Shi; Guojiang Chen
Opposite role of tumor necrosis factor receptors in dextran sulfate sodium-induced colitis in mice.
PloS one 2012;7(12):e52924.
2012: Chunxia Qiao; Jiannan Feng; Jing Geng; Leiming Guo; Meiyun Hu; Xiaoling Lang; Xinying Li; Yan Li; Zhou Lin; Ming Lv; Yuanfang Ma; Beifen Shen
Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation.
BMC immunology 2012;13():40.
2011: Jiyan Zhang; Beifen Shen
SHP limits TLR signaling, an inducible transcriptional corepressor.
Cellular & molecular immunology 2011;8(6):445-6.
2011: Huawei Wei; Zhou Lin; Jiannan Feng; Hui Peng; Renfeng Guo; Gencheng Han; Shusheng Geng; Xiaoling Lang; Yingxun Sun; Beifen Shen; Yan Li
Identification of conformational core epitope Lys⁶⁸ in C5a based on the 3-D modeling complex C5a and its functional antibody F20.
Molecular immunology 2011;48(12-13):1377-83.
2011: Gencheng Han; Shaoxia Geng; Yan Li; Guojiang Chen; Renxi Wang; Xinying Li; Yuanfang Ma; Beifen Shen; Yan Li
γδT-cell function in sepsis is modulated by C5a receptor signalling.
Immunology 2011;133(3):340-9.
2011: Guojiang Chen; Yuemei Yang; Xudong Gao; Yan Dou; Huihui Wang; Gencheng Han; Renxi Wang; Jianan Wang; Liyan Wang; Xinying Li; Renfeng Guo; He Xiao; Beifen Shen; Yan Li
Blockade of complement activation product C5a activity using specific antibody attenuates intestinal damage in trinitrobenzene sulfonic acid induced model of colitis.
Laboratory investigation; a journal of technical methods and pathology 2011;91(3):472-83.
2011: Jing Wang; Ruihong Tang; Ming Lv; Qingyang Wang; Xueying Zhang; Yuanyuan Guo; Hong Chang; Chunxia Qiao; He Xiao; Xinying Li; Yan Li; Beifen Shen; Jiyan Zhang
Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis.
Molecular biology of the cell 2011;22(1):117-27.
2011: Yan Li; Jiannan Feng; Shaoxia Geng; Shusheng Geng; Huawei Wei; Guojiang Chen; Xinying Li; Liyan Wang; Renxi Wang; Hui Peng; Gencheng Han; Beifen Shen; Yan Li
The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity.
Molecular immunology 2011;48(4):670-7.
2011: Ming Shi; Dan Liu; Huijun Duan; Lu Qian; Lina Wang; Lijia Niu; Huipeng Zhang; Zheng Yong; Zehui Gong; Lun Song; Ming Yu; Meiru Hu; Qing Xia; Beifen Shen; Ning Guo
The β2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells.
Breast cancer research and treatment 2011;125(2):351-62.
2010: Ming Shi; Dan Liu; Huijun Duan; Beifen Shen; Ning Guo
Metastasis-related miRNAs, active players in breast cancer invasion, and metastasis.
Cancer metastasis reviews 2010;29(4):785-99.
2010: Liyan Wang; Gencheng Han; Renxi Wang; Guojiang Chen; Ruonan Xu; He Xiao; Xia Li; Shaoxia Geng; Yurong Li; Xinying Li; Jianan Wang; Jiannan Feng; Niels C Riedemann; Renfeng Guo; Beifen Shen; Yan Li
Regulation of IL-8 production by complement-activated product, C5a, in vitro and in vivo during sepsis.
Clinical immunology (Orlando, Fla.) 2010;137(1):157-65.
2010: Jiyan Zhang; Ning Zhu; Qingyang Wang; Jing Wang; Yuanfang Ma; Chunxia Qiao; Yan Li; Xinying Li; Bing Su; Beifen Shen
MEKK3 overexpression contributes to the hyperresponsiveness of IL-12-overproducing cells and CD4+ T conventional cells in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(6):3554-63.
2010: Ming Lv; Zhou Lin; Chunxia Qiao; Shusheng Gen; Xiaoling Lang; Yan Li; Jiannan Feng; Beifen Shen
Novel anti-CD20 antibody TGLA with enhanced antibody-dependent cell-mediated cytotoxicity mediates potent anti-lymphoma activity.
Cancer letters 2010;294(1):66-73.
2010: Guojun Cao; Baochun Huang; Zhaohui Liu; Jiyan Zhang; Hua Xu; Wei Xia; Jie Li; Shaohua Li; Liucun Chen; Hongmei Ding; Qiang Zhao; Ming Fan; Beifen Shen; Ningsheng Shao
Intronic miR-301 feedback regulates its host gene, ska2, in A549 cells by targeting MEOX2 to affect ERK/CREB pathways.
Biochemical and biophysical research communications 2010;396(4):978-82.
2010: Ming Shi; Dan Liu; Beifen Shen; Ning Guo
Helpers of the cellular gatekeeper-miRNAs dance in P53 network.
Biochimica et biophysica acta 2010;1805(2):218-25.
2010: Ming Lv; Chunxia Qiao; Zhou Lin; Ming Yu; Chunmei Hou; Yingxun Sun; Yan Li; Jiannan Feng; Beifen Shen
The novel non-mitogenic anti-CD3 antibody, mini-yCD3, delivers a partial TCR signal.
International immunopharmacology 2010;10(2):200-6.
2010: Xia Li; Guojiang Chen; Yan Li; Renxi Wang; Liyan Wang; Zhou Lin; Xudong Gao; Jiannan Feng; Yuanfang Ma; Beifen Shen; Yan Li; Gencheng Han
Involvement of T cell Ig Mucin-3 (Tim-3) in the negative regulation of inflammatory bowel disease.
Clinical immunology (Orlando, Fla.) 2010;134(2):169-77.
2010: Gencheng Han; Renxi Wang; Guojiang Chen; Jianan Wang; Ruonan Xu; Liyan Wang; Jiannan Feng; Xia Li; Renfeng Guo; Li Fu; Beifen Shen; Yan Li
Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta.
Immunology 2010;129(2):197-206.
2010: Xin Gu; Xiaoling Jia; Jiannan Feng; Beifen Shen; Ying Huang; Shusheng Geng; Yingxun Sun; Yugang Wang; Yan Li; Mian Long
Molecular modeling and affinity determination of scFv antibody: proper linker peptide enhances its activity.
Annals of biomedical engineering 2010;38(2):537-49.
2010: Ming Shi; Dan Liu; Huijun Duan; Caili Han; Bo Wei; Lu Qian; Changguo Chen; Liang Guo; Meiru Hu; Ming Yu; Lun Song; Beifen Shen; Ning Guo
Catecholamine up-regulates MMP-7 expression by activating AP-1 and STAT3 in gastric cancer.
Molecular cancer 2010;9():269.
2010: Jie Dong; Yaping Gao; Yu Liu; Jinxia Shi; Jiannan Feng; Zhanguo Li; Heping Pan; Yanning Xue; Chuan Liu; Beifen Shen; Ningsheng Shao; Guang Yang
The protective antibodies induced by a novel epitope of human TNF-alpha could suppress the development of collagen-induced arthritis.
PloS one 2010;5(1):e8920.
2010: Jing Wang; Ruihong Tang; Ming Lv; Jiyan Zhang; Beifen Shen
Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-alpha-induced cell death.
Molecular cancer 2010;9():6.
2010: Lu Qian; Dan Li; Zhihong Yang; Meiru Hu; Ming Yu; Ming Shi; Beifen Shen; Ning Guo
Construction and expression of a spliced variant of Epstein-Barr virus bzlf1 and preparation of its polyclonal antibody.
Preparative biochemistry & biotechnology 2010;40(1):46-56.
2009: Jian Cui; Qingyang Wang; Jing Wang; Ming Lv; Ning Zhu; Yan Li; Jiannan Feng; Beifen Shen; Jiyan Zhang
Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells.
Molecular cancer therapeutics 2009;8(12):3214-22.
2009: Guojiang Chen; Gencheng Han; Jianan Wang; Renxi Wang; Ruonan Xu; Beifen Shen; Jiahua Qian; Yan Li
Natural killer cells modulate overt autoimmunity to homeostasis in nonobese diabetic mice after anti-CD3 F(ab')2 antibody treatment through secreting transforming growth factor-beta.
The American journal of pathology 2009;175(3):1086-94.
2009: Xiaoxiao Cao; Shaohua Li; Liucun Chen; Hongmei Ding; Hua Xu; Yanping Huang; Jie Li; Nongle Liu; Weihong Cao; Yanjun Zhu; Beifen Shen; Ningsheng Shao
Combining use of a panel of ssDNA aptamers in the detection of Staphylococcus aureus.
Nucleic acids research 2009;37(14):4621-8.
2009: Shaohua Li; Hua Xu; Hongmei Ding; Yanping Huang; Xiaoxiao Cao; Guang Yang; Jie Li; Zhigang Xie; Yuhong Meng; Xuguang Li; Qiang Zhao; Beifen Shen; Ningsheng Shao
Identification of an aptamer targeting hnRNP A1 by tissue slide-based SELEX.
The Journal of pathology 2009;218(3):327-36.
2009: Dan Li; Lu Qian; Changguo Chen; Ming Shi; Ming Yu; Meiru Hu; Lun Song; Beifen Shen; Ning Guo
Down-regulation of MHC class II expression through inhibition of CIITA transcription by lytic transactivator Zta during Epstein-Barr virus reactivation.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(4):1799-809.
2009: Chunxia Qiao; Leiming Guo; Jian Sun; Yan Li; Zhou Lin; Ming Lv; Jiannan Feng; Beifen Shen
Suitable transmembrane domain significantly increase the surface-expression level of Fc(epsilon)RIalpha in 293T cells.
Journal of biotechnology 2009;139(3):195-202.
2009: Chao Bian; Xiuqin Zhang; Xingfeng Cai; Linqi Zhang; Zhiwei Chen; Ye Zha; Ying Xu; Ke Xu; Wei Lu; Linchen Yan; Jianwei Yuan; Jiannan Feng; Pei Hao; Qidi Wang; Guoping Zhao; Gang Liu; Xueliang Zhu; Hao Shen; Bojian Zheng; Beifen Shen; Bing Sun
Conserved amino acids W423 and N424 in receptor-binding domain of SARS-CoV are potential targets for therapeutic monoclonal antibody.
Virology 2009;383(1):39-46.
2009: Guojiang Chen; Gencheng Han; Jiannan Feng; Jianan Wang; Renxi Wang; Ruonan Xu; Beifen Shen; Jiahua Qian; Yan Li
Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells.
PloS one 2009;4(9):e7034.
2009: Jian Cui; Ning Zhu; Qingyang Wang; Ming Yu; Jiannan Feng; Yan Li; Jiyan Zhang; Beifen Shen
p38 MAPK contributes to CD54 expression and the enhancement of phagocytic activity during macrophage development.
Cellular immunology 2009;256(1-2):6-11.
2009: Renxi Wang; Gencheng Han; Lun Song; Jianan Wang; Guojiang Chen; Ruonan Xu; Ming Yu; Jiahua Qian; Beifen Shen; Yan Li
CD8+ regulatory T cells are responsible for GAD-IgG gene-transferred tolerance induction in NOD mice.
Immunology 2009;126(1):123-31.
2008: Jian Sun; Zhou Lin; Jiannan Feng; Yan Li; Beifen Shen
BAFF-targeting therapy, a promising strategy for treating autoimmune diseases.
European journal of pharmacology 2008;597(1-3):1-5.
2008: R Wang; G Han; J Wang; G Chen; R Xu; L Wang; X Li; Beifen Shen; Yan Li
The pathogenic role of interleukin-27 in autoimmune diabetes.
Cellular and molecular life sciences : CMLS 2008;65(23):3851-60.
2008: Han Lu; Ming Shi; Mingli Wang; Zhigang Xie; Meiru Hu; Ming Yu; Beifen Shen; Yuanfang Ma; Ning Guo
In vitro and in vivo antitumor effect of a trivalent bispecific antibody targeting ErbB2 and CD16.
Cancer biology & therapy 2008;7(11):1744-50.
2008: Guogang Yuan; Lu Qian; Lun Song; Ming Shi; Dan Li; Ming Yu; Meiru Hu; Beifen Shen; Ning Guo
Heregulin-beta promotes matrix metalloproteinase-7 expression via HER2-mediated AP-1 activation in MCF-7 cells.
Molecular and cellular biochemistry 2008;318(1-2):73-9.
2008: Jianhua Zhang; Q Wang; N Zhu; M Yu; Beifen Shen; Jialing Xiang; Anning Lin
Cyclic AMP inhibits JNK activation by CREB-mediated induction of c-FLIP(L) and MKP-1, thereby antagonizing UV-induced apoptosis.
Cell death and differentiation 2008;15(10):1654-62.
2008: M Wang; Z Xie; M Shi; H Lu; M Yu; M Hu; F Lu; Y Ma; Beifen Shen; N Guo
A new strategy to induce effective antitumour response in vitro and in vivo.
Scandinavian journal of immunology 2008;68(3):287-96.
2008: Renxi Wang; Gencheng Han; Jianan Wang; Lun Song; Guojiang Chen; Ruonan Xu; Liyan Wang; Xia Li; Beifen Shen; Yan Li
Diabetes is not prevented by Foxp3-transduced CD4(+)T cells under the IL-12Rbeta2 promoter control.
Molecular immunology 2008;45(14):3814-7.
2008: Benxu Wang; Zhan Liu; Yu Liu; Beifen Shen; Chuan Liu; Ningsheng Shao
[Conserved amino-acid residue mutations in epitope of human cytomegalovirus antigen M].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2008;24(7):1128-32.
2008: Guogang Yuan; Lu Qian; Ming Shi; Feng Lu; Dan Li; Meiru Hu; Ming Yu; Beifen Shen; Ning Guo
HER2-dependent MMP-7 expression is mediated by activated STAT3.
Cellular signalling 2008;20(7):1284-91.
2008: Guang Yang; Yaping Gao; Jiannan Feng; Yong Huang; Shaohua Li; Yu Liu; Chuan Liu; Ming Fan; Beifen Shen; Ningsheng Shao
C-terminus of TRAP in Staphylococcus can enhance the activity of lysozyme and lysostaphin.
Acta biochimica et biophysica Sinica 2008;40(5):452-8.
2008: Ning Zhu; Jian Cui; Chunxia Qiao; Yong Li; Yuanfang Ma; Jiyan Zhang; Beifen Shen
cAMP modulates macrophage development by suppressing M-CSF-induced MAPKs activation.
Cellular & molecular immunology 2008;5(2):153-7.
2008: Guojiang Chen; Gencheng Han; Jianan Wang; Renxi Wang; Ruonan Xu; Beifen Shen; Jiahua Qian; Yan Li
Induction of active tolerance and involvement of CD1d-restricted natural killer T cells in anti-CD3 F(ab')2 treatment-reversed new-onset diabetes in nonobese diabetic mice.
The American journal of pathology 2008;172(4):972-9.
2008: Renxi Wang; Gencheng Han; Jianan Wang; Lun Song; Guojiang Chen; Ruonan Xu; Chunmei Zhang; Ming Yu; Jiahua Qian; Beifen Shen; Yan Li
GAD-IgG-inducing CD4+Foxp3+Treg cells suppressing diabetes are involved in the increasing ratio of CD80+:CD86+ CELLS in NOD mice.
Archives of medical research 2008;39(3):299-305.
2008: Feng Lu; Qing Xia; Yuanfang Ma; Guogang Yuan; Huiping Yan; Lu Qian; Meiru Hu; Mingli Wang; Han Lu; Hongli Wang; Bingyu Liu; Yan Xue; Hongxia Wang; Mingyuan Li; Beifen Shen; Ning Guo
Serum proteomic-based analysis for the identification of a potential serological marker for autoimmune hepatitis.
Biochemical and biophysical research communications 2008;367(2):284-90.
2008: Jing Wang; Zhou Lin; Chun Xia Qiao; Ming Lv; Ming Yu; He Xiao; Qingyang Wang; Liyan Wang; Jiannan Feng; Beifen Shen; Yuanfang Ma; Yan Li
Characterization of a novel anti-DR5 monoclonal antibody WD1 with the potential to induce tumor cell apoptosis.
Cellular & molecular immunology 2008;5(1):55-60.
2008: Guojiang Chen; Gencheng Han; Jianan Wang; Renxi Wang; Ruonan Xu; Beifen Shen; Jiahua Qian; Yan Li
Essential roles of TGF-beta in anti-CD3 antibody therapy: reversal of diabetes in nonobese diabetic mice independent of Foxp3+CD4+ regulatory T cells.
Journal of leukocyte biology 2008;83(2):280-7.
2008: Gencheng Han; Renxi Wang; Guojiang Chen; Jianan Wang; Ruonan Xu; Jiannan Feng; Ming Yu; Xiaobing Wu; Jiahua Qian; Beifen Shen; Yan Li
Gene delivery GAD 500 autoantigen by AAV serotype 1 prevented diabetes in NOD mice: transduction efficiency do not play important roles.
Immunology letters 2008;115(2):110-6.
2008: H Zhang; M Yu; M Hu; L Qian; L Chen; M Shi; Beifen Shen; N Guo
Overexpression, refolding, purification of Erbin PDZ domain from Escherichia coli and preparation of its polyclonal antibody.
Preparative biochemistry & biotechnology 2008;38(3):282-93.
2008: Shusheng Geng; Hong Chang; Weisong Qin; Yan Li; Jiannan Feng; Beifen Shen
Overexpression, effective renaturation, and bioactivity of novel single-chain antibodies against TNF-alpha.
Preparative biochemistry & biotechnology 2008;38(1):74-86.
2008: Jianing Wang; Jiannan Feng; Ming Shi; Lu Qian; Liyong Chen; Ming Yu; Ruonan Xu; Beifen Shen; Ning Guo
De novo design of ErbB2 epitope targeting fusion protein stabilized by coiled coil structure.
Molecular immunology 2008;45(1):106-16.
2007: Yugang Wang; Leiming Guo; Kunpeng Zhao; Jugao Chen; Jiannan Feng; Yingxun Sun; Yan Li; Beifen Shen
Novel chimeric anti-ricin antibody C4C13 with neutralizing activity against ricin toxicity.
Biotechnology letters 2007;29(12):1811-6.
2007: Yan Zhang; Xiaoyun Pu; Ming Shi; Liyong Chen; Lu Qian; Yuhua Song; Guogang Yuan; Hao Zhang; Ming Yu; Meiru Hu; Beifen Shen; Ning Guo
c-Jun, a crucial molecule in metastasis of breast cancer and potential target for biotherapy.
Oncology reports 2007;18(5):1207-12.
2007: Renxi Wang; Lun Song; Gencheng Han; Jianan Wang; Guojiang Chen; Ruonan Xu; Ming Yu; Jiahua Qian; Beifen Shen; Yong Li
Mechanisms of regulatory T-cell induction by antigen-IgG-transduced splenocytes.
Scandinavian journal of immunology 2007;66(5):515-22.
2007: Liyong Chen; Lu Qian; Zhiyi Zhang; Ming Shi; Yuhua Song; Guogang Yuan; Hao Zhang; Meiru Hu; Ming Yu; Xuemin Zhang; Beifen Shen; Ning Guo
Mutational analysis of ErbB2 intracellular localization.
Histochemistry and cell biology 2007;128(5):473-83.
2007: Jing Wang; Zhenhui Yang; Ming Shi; Yong Li; Ning Guo; Beifen Shen; Jiannan Feng
Expression, purification and characterization of soluble human interleukin-6 receptor alpha-chain and its mutant protein in Escherichia coli.
Biotechnology letters 2007;29(9):1323-7.
2007: Renxi Wang; Gencheng Han; Jianan Wang; Lun Song; Guojiang Chen; Ruonan Xu; Ming Yu; Jiahua Qian; Beifen Shen; Yan Li
Foxp3-expressing CD4(+)T cells under the control of INF-gamma promoter prevent diabetes in NOD mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(8):1551-7.
2007: Hong Chang; Weisong Qin; Yan Li; Jiyan Zhang; Zhou Lin; Ming Lv; Yingxun Sun; Jiannan Feng; Beifen Shen
A novel human scFv fragment against TNF-alpha from de novo design method.
Molecular immunology 2007;44(15):3789-96.
2007: Jiyan Zhang; Beifen Shen; Anning Lin
Novel strategies for inhibition of the p38 MAPK pathway.
Trends in pharmacological sciences 2007;28(6):286-95.
2007: Yugang Wang; Jiannan Feng; Ying Huang; Xin Gu; Yingxun Sun; Yan Li; Beifen Shen
The design, construction and function of a new chimeric anti-CD20 antibody.
Journal of biotechnology 2007;129(4):726-31.
2007: Renxi Wang; Gencheng Han; Jianan Wang; Lun Song; Guojiang Chen; Ruonan Xu; Ming Yu; Jiahua Qian; Beifen Shen; Yan Li
The role of STAT3 in antigen-IgG inducing regulatory CD4(+)Foxp3(+)T cells.
Cellular immunology 2007;246(2):103-9.
2007: Weisong Qin; Jiannan Feng; Yan Li; Zhou Lin; Beifen Shen
A novel domain antibody rationally designed against TNF-alpha using variable region of human heavy chain antibody as scaffolds to display antagonistic peptides.
Molecular immunology 2007;44(9):2355-61.
2007: Jing Wang; Yuzuru Minemoto; Anning Lin; Yan Li; Beifen Shen; Jiyan Zhang
IKK antagonizes CD95 ligation-mediated apoptosis by regulating NF-kappaB activity.
Molecular immunology 2007;44(8):2139-43.
2007: Yan Zhang; Xiaoyun Pu; Ming Shi; Liyong Chen; Yuhua Song; Lu Qian; Guogang Yuan; Hao Zhang; Ming Yu; Meiru Hu; Beifen Shen; Ning Guo
Critical role of c-Jun overexpression in liver metastasis of human breast cancer xenograft model.
BMC cancer 2007;7():145.
2007: Ming Lv; Yan Li; Ming Yu; Yingxun Sun; Zhou Lin; Chunxia Qiao; Qun Luo; Xin Gu; Ying Huang; Jiannan Feng; Beifen Shen
Structured to reduce the mitogenicity of anti-CD3 antibody based on computer-guided molecular design.
The international journal of biochemistry & cell biology 2007;39(6):1142-55.
2006: Shusheng Geng; Jiannan Feng; Yan Li; Yingxun Sun; Xin Gu; Ying Huang; Yugang Wang; Xianjiang Kang; Hong Chang; Beifen Shen
Binding activity difference of anti-CD20 scFv-Fc fusion protein derived from variable domain exchange.
Cellular & molecular immunology 2006;3(6):439-43.
2006: Lu Qian; Zhiyi Zhang; Ming Shi; Ming Yu; Meiru Hu; Qing Xia; Beifen Shen; Ning Guo
Expression and distribution of HSP27 in response to G418 in different human breast cancer cell lines.
Histochemistry and cell biology 2006;126(5):593-601.
2006: Jiannan Feng; Zhenhui Yang; Yan Li; Meiru Hu; Ming Yu; Weisong Qin; Jian Sun; Beifen Shen
The rational designed antagonist derived from the complex structure of interleukin-6 and its receptor affectively blocking interleukin-6 might be a promising treatment in multiple myeloma.
Biochimie 2006;88(9):1265-73.
2006: Weisong Qin; Jiannan Feng; Yan Li; Zhou Lin; Beifen Shen
De novo design TNF-alpha antagonistic peptide based on the complex structure of TNF-alpha with its neutralizing monoclonal antibody Z12.
Journal of biotechnology 2006;125(1):57-63.
2006: Jian Sun; Jiannan Feng; Yan Li; Beifen Shen
A novel BLyS antagonist peptide designed based on the 3-D complex structure of BCMA and BLyS.
Biochemical and biophysical research communications 2006;346(4):1158-62.
2006: Jian Sun; Yaz Li; Ming Yu; Yingxun Sun; Jiannan Feng; Beifen Shen
Analysis of an anti-B lymphocyte stimulator monoclonal antibody B7 and its binding activity to myeloma and lymphoma cell lines.
Hybridoma (2005) 2006;25(4):238-42.
2006: Jianwei Guo; Beifen Shen; Yingxun Sun; Ming Yu; Meiru Hu
A novel neutralizing monoclonal antibody against both ricin toxin A and ricin toxin B, and application of a rapid sandwich enzyme-linked immunosorbent assay.
Hybridoma (2005) 2006;25(4):225-9.
2006: Lu Qian; Liyong Chen; Ming Shi; Ming Yu; Baofeng Jin; Meiru Hu; Qing Xia; Xueming Zhang; Beifen Shen; Ning Guo
A novel cis-acting element in Her2 promoter regulated by Stat3 in mammary cancer cells.
Biochemical and biophysical research communications 2006;345(2):660-8.
2006: Jian Sun; Yan Li; Yingxun Sun; Ming Yu; Jiannan Feng; Beifen Shen
Preparation and characterization of a monoclonal antibody against human B lymphocyte stimulator.
Hybridoma (2005) 2006;25(2):80-5.
2006: Pinliang Hu; Tao Zhou; Lu Qian; Jianing Wang; Ming Shi; Ming Yu; Yi Yang; Xuemin Zhang; Beifen Shen; Ning Guo
Sequestering ErbB2 in endoplasmic reticulum by its autoinhibitor from translocation to cell surface: an autoinhibition mechanism of ErbB2 expression.
Biochemical and biophysical research communications 2006;342(1):19-27.
2006: Guang Yang; Yaping Gao; Jie Dong; Yanning Xue; Ming Fan; Beifen Shen; Chuan Liu; Ningsheng Shao
A novel peptide isolated from phage library to substitute a complex system for a vaccine against staphylococci infection.
Vaccine 2006;24(8):1117-23.
2006: Cansheng Zhu; Xuesong Liu; Jiannan Feng; Wei Zhang; Beifen Shen; Weiming Ou'yang; Yunxin Cao; Boquan Jin
Characterization of the neutralizing activity of three anti-human TNF monoclonal antibodies and prediction of their TNF epitopes by molecular modeling and mutant protein approach.
Immunology letters 2006;102(2):177-83.
2006: Weisong Qin; Jiannan Feng; Yan Li; Zhou Lin; Beifen Shen
Fusion protein of CDR mimetic peptide with Fc inhibit TNF-alpha induced cytotoxicity.
Molecular immunology 2006;43(6):660-6.
2006: Jie Li; Guang Yang; Shaohua Li; Guojun Cao; Qiang Zhao; Xuemei Liu; Ming Fan; Beifen Shen; Ningsheng Shao
3'-Poly(A) tail enhances siRNA activity against exogenous reporter genes in MCF-7 cells.
Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research 2006;2(2):195-204.
2005: Ming Shi; Zhigang Xie; Ming Yu; Beifen Shen; Ning Guo
Controlled growth of Chinese hamster ovary cells and high expression of antibody-IL-2 fusion proteins by temperature manipulation.
Biotechnology letters 2005;27(23-24):1879-84.
2005: Pinliang Hu; Jiannan Feng; Tao Zhou; Jianing Wang; Baofeng Jing; Ming Yu; Meiru Hu; Xuemin Zhang; Beifen Shen; Ning Guo
In vivo identification of the interaction site of ErbB2 extracellular domain with its autoinhibitor.
Journal of cellular physiology 2005;205(3):335-43.
2005: G Zhong; J Wang; M Xu; Z Xie; M Yu; J Wang; T Zhou; W Gong; Y Sun; M Hu; X Zhang; Beifen Shen; N Guo
Enhanced maturation and functional capacity of dendritic cells induced by mannosylated L2 domain of ErbB2 receptor.
Scandinavian journal of immunology 2005;62(2):108-16.
2005: Wei Zhang; Jiannan Feng; Yan Li; Ning Guo; Beifen Shen
Humanization of an anti-human TNF-alpha antibody by variable region resurfacing with the aid of molecular modeling.
Molecular immunology 2005;42(12):1445-51.
2005: Guang Yang; Yaping Gao; Jie Dong; Chuan Liu; Yanning Xue; Ming Fan; Beifen Shen; Ningsheng Shao
A novel peptide screened by phage display can mimic TRAP antigen epitope against Staphylococcus aureus infections.
The Journal of biological chemistry 2005;280(29):27431-5.
2005: Jiannan Feng; Yan Li; Wei Zhang; Beifen Shen
Rational design of potent mimic peptide derived from monoclonal antibody: antibody mimic design.
Immunology letters 2005;98(2):311-6.
2005: Zhenhui Yang; Jiannan Feng; Yan Li; Meiru Hu; Lun Song; Ming Yu; Weisong Qin; Beifen Shen
Structure-based design and characterization of a Novel IL-6 antagonist peptide.
Molecular immunology 2005;42(9):1015-21.
2005: Gencheng Han; Yong Li; Jianan Wang; Renxi Wang; Guojiang Chen; Lun Song; Ruonan Xu; Ming Yu; Xiaobing Wu; Jiahua Qian; Beifen Shen
Active tolerance induction and prevention of autoimmune diabetes by immunogene therapy using recombinant adenoassociated virus expressing glutamic acid decarboxylase 65 peptide GAD(500-585).
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4516-24.
2005: Guojun Cao; Guang Yang; Zhaohui Liu; Xuemei Liu; Jie Zhang; Dajin Zhang; Nongle Liu; Hongmei Ding; Ming Fan; Beifen Shen; Ningsheng Shao
Identification of the RNA chaperone activity of recombinant human tumor necrosis factor alpha in vitro.
Biochemical and biophysical research communications 2005;328(2):573-9.
2005: Weisong Qin; Jiannan Feng; Yan Li; Zhou Lin; Beifen Shen
Changes of primary sequence and secondary structure proximal to the 5' end of the stop codon substantially increases the expression of the variable region of an antibody in E. coli.
Biotechnology letters 2005;27(2):131-4.
2005: Zhigang Xie; Ning Guo; Ming Yu; Meiru Hu; Beifen Shen
A new format of bispecific antibody: highly efficient heterodimerization, expression and tumor cell lysis.
Journal of immunological methods 2005;296(1-2):95-101.
2004: Zhenhui Yang; Jiannan Feng; Meiru Hu; Yan Li; Ming Yu; Weisong Qin; Beifen Shen
A novel hIL-6 antagonist peptide from computer-aided design contributes to suppression of apoptosis in M1 cells.
Biochemical and biophysical research communications 2004;325(2):518-24.
2004: Liyong Chen; Zhigang Xie; Yan Teng; Minggao Wang; Ming Shi; Lu Qian; Meiru Hu; Jiannan Feng; Xiao Yang; Beifen Shen; Ning Guo
Highly efficient selection of the stable clones expressing antibody-IL-2 fusion protein by a dicistronic expression vector containing a mutant neo gene.
Journal of immunological methods 2004;295(1-2):49-56.
2004: Lun Song; Jianan Wang; Renxi Wang; Ming Yu; Y Sun; Gencheng Han; Yong Li; Jiahua Qian; David W Scott; Y Kang; Nadejda Soukhareva; Beifen Shen
Retroviral delivery of GAD-IgG fusion construct induces tolerance and modulates diabetes: a role for CD4+ regulatory T cells and TGF-beta?
Gene therapy 2004;11(20):1487-96.
2004: Weisong Qin; Jiannan Feng; Wei Zhang; Yan Li; Beifen Shen
A novel TNFalpha antagonizing peptide-Fc fusion protein designed based on CDRs of TNFalpha neutralizing monoclonal antibody.
Biochemical and biophysical research communications 2004;322(3):1024-8.
2004: Jiannan Feng; Yan Li; Beifen Shen
The design of antagonist peptide of hIL-6 based on the binding epitope of hIL-6 by computer-aided molecular modeling.
Peptides 2004;25(7):1123-31.
2004: Wei Zhang; Jiannan Feng; Beifen Shen
Identification of binding epitope of a monoclonal antibody (Z12) against human TNF-alpha using computer modeling and deletion mutant technique.
Science in China. Series C, Life sciences / Chinese Academy of Sciences 2004;47(3):279-86.
2004: Beili Wu; Pengyun Li; Yiwei Liu; Zhiyong Lou; Yi Ding; Cuiling Shu; Sheng Ye; Mark Bartlam; Beifen Shen; Zihe Rao
3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(22):8348-53.
2004: Jiannan Feng; Zhigang Xie; Ming Yu; Ning Guo; Beifen Shen
The difference of binding epitopes on human CD16 (FcgammaRIII) interacted with hIgG1 and monoclonal antibody B88-9.
Molecular immunology 2004;41(1):93-8.
2004: Xuemei Liu; Guojun Cao; Hongmei Ding; Dajin Zhang; Guang Yang; Nongle Liu; Ming Fan; Beifen Shen; Ningsheng Shao
Screening of functional antidotes of RNA aptamers against bovine thrombin.
FEBS letters 2004;562(1-3):125-8.
2003: Beili Wu; Pengyun Li; Cuiling Shu; Beifen Shen; Zihe Rao
Crystallization and preliminary crystallographic studies of the C-terminal domain of human FKBP52.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2269-71.
2003: Zhigang Xie; Ming Shi; Jiannan Feng; Ming Yu; Yingxun Sun; Beifen Shen; Ning Guo
A trivalent anti-erbB2/anti-CD16 bispecific antibody retargeting NK cells against human breast cancer cells.
Biochemical and biophysical research communications 2003;311(2):307-12.
2003: Guang Yang; Huichai Cheng; Chuan Liu; Yanning Xue; Yaping Gao; Nongle Liu; Bo Gao; Dongping Wang; Shanru Li; Beifen Shen; Ningsheng Shao
Inhibition of Staphylococcus aureus pathogenesis in vitro and in vivo by RAP-binding peptides.
Peptides 2003;24(11):1823-8.
2003: Jiannan Feng; Zhigang Xie; Ning Guo; Beifen Shen
Design and assembly of anti-CD16 ScFv antibody with two different linker peptides.
Journal of immunological methods 2003;282(1-2):33-43.
2003: Fei Sun; Pengyun Li; Yi Ding; Liwei Wang; Mark Bartlam; Cuiling Shu; Beifen Shen; Hualiang Jiang; Song Li; Zihe Rao
Design and structure-based study of new potential FKBP12 inhibitors.
Biophysical journal 2003;85(5):3194-201.
2003: Junhai Han; Xiaohui Yan; Jie Zhu; Xiaoyong Zhi; Yuhui Zang; Beifen Shen; Junchuan Qin
Expression of a novel recombinant dual human stem cell factor in insect cells.
Protein expression and purification 2003;31(2):311-7.
2003: Ming Shi; Zhigang Xie; Jiannan Feng; Yingxun Sun; Ming Yu; Beifen Shen; Ning Guo
A recombinant anti-erbB2, scFv-Fc-IL-2 fusion protein retains antigen specificity and cytokine function.
Biotechnology letters 2003;25(10):815-9.
2003: Chenglong Wang; Ming Zhang; Guang Yang; Dajing Zhang; Hongmei Ding; Huixing Wang; Ming Fan; Beifen Shen; Ningsheng Shao
Single-stranded DNA aptamers that bind differentiated but not parental cells: subtractive systematic evolution of ligands by exponential enrichment.
Journal of biotechnology 2003;102(1):15-22.
2003: Jiyan Zhang; Yan Li; Ming Yu; Ben D Chen; Beifen Shen
Lineage-dependent NF-kappaB activation contributes to the resistance of human macrophages to apoptosis.
The hematology journal : the official journal of the European Haematology Association / EHA 2003;4(4):277-84.
2003: Xuemei Liu; Dajin Zhang; Guojun Cao; Guang Yang; Hongmei Ding; Gang Liu; Ming Fan; Beifen Shen; Ningsheng Shao
RNA aptamers specific for bovine thrombin.
Journal of molecular recognition : JMR 2003;16(1):23-7.
2003: Pengyun Li; Yi Ding; Beili Wu; Cuiling Shu; Beifen Shen; Zihe Rao
Structure of the N-terminal domain of human FKBP52.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 1):16-22.
2002: Yu Lan; Xuemin Zhang; Pingdi Yang; Meiru Hu; Ming Yu; Yi Yang; Beifen Shen
Effects of inhibition of ubiquitin-proteasome pathway on human primary leukemic cells.
Science in China. Series C, Life sciences / Chinese Academy of Sciences 2002;45(6):647-55.
2002: Pengyun Li; Cuiling Shu; Beili Wu; Yi Ding; Beifen Shen; Zihe Rao
Crystallization and preliminary X-ray diffraction analysis of FKBP52 N-terminal domain.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 12):2168-9.
2002: Duncheng Wang; Yan Li; Beifen Shen
A novel erythroid differentiation related gene EDRF1 upregulating globin gene expression in HEL cells.
Chinese medical journal 2002;115(11):1701-5.
2002: Lun Song; Yan Li; Yingxun Sun; Beifen Shen
[Study on the biological activity and molecular mechanism of IFNalpha on human myeloma cell line Sko-007].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2002;23(10):517-9.
2002: Pengyun Li; Liwei Wang; Yi Ding; Beili Wu; Cuiling Shu; Aihua Nie; Song Li; Beifen Shen; Zihe Rao
Crystallization and preliminary X-ray diffraction analysis of FKBP12 complexed with a novel neurotrophic ligand.
Protein and peptide letters 2002;9(5):459-63.
2002: Lun Song; Yong Li; Yingxun Sun; Beifen Shen
Mcl-1 mediates cytokine deprivation induced apoptosis of human myeloma cell line XG-7.
Chinese medical journal 2002;115(8):1241-3.
2002: Duncheng Wang; Shuhua Ma; Shengqi Wang; Beifen Shen
Antisense EDRF1 gene inhibited GATA-1 transcription factor DNA-binding activity in K562 cells.
Science in China. Series C, Life sciences / Chinese Academy of Sciences 2002;45(3):289-97.
2001: Duncheng Wang; Beifen Shen; Yan Li
[A novel erythroid differentiation related gene EDRF1 upreguated globin gene expression in HEL cells].
Zhonghua yi xue za zhi 2001;81(24):1512-5.
2001: D Wang; Y Li; Beifen Shen
Initial function analysis of a novel erythroid differentiation related gene EDRF1.
Science in China. Series C, Life sciences / Chinese Academy of Sciences 2001;44(5):489-96.
2001: Lun Song; Beifen Shen; Yan Li
Association and contribution of ERK to IL-6-induced activation of signal transducer and activator of transcription in a human myeloma cell line.
Chinese medical journal 2001;114(9):954-7.
2001: J Song; Yan Li; Beifen Shen
[Activation of PKA pathway inhibits reactivity of human myeloma cell line-U266 to IL-6].
Zhonghua zhong liu za zhi [Chinese journal of oncology] 2001;23(4):278-80.
2001: H Liu; Ning Mao; C Hou; X Li; Beifen Shen; Pei-Hsien Tang
Protective effect of human CD40-Ig fusion protein in a murine model of acute graft-versus-host disease.
Chinese medical journal 2001;114(7):685-9.
2001: X Wang; Duncheng Wang; X Chen; M Hu; J Wang; Yong Li; N Guo; Beifen Shen
cDNA cloning and function analysis of two novel erythroid differentiation related genes.
Science in China. Series C, Life sciences / Chinese Academy of Sciences 2001;44(1):99-105.
2000: L Song; Yan Li; Beifen Shen
[Study of IL-6 signal transduction pathway in a human multiple myeloma cell line--Sko-007].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2000;21(11):569-71.
2000: L Song; Beifen Shen
[Signal transduction and biological function of IL-6 in a human myeloma cell line-XG-7].
Zhonghua yi xue za zhi 2000;80(11):845-8.
2000: D Zhang; Junchuan Qin; Yuhui Zang; Jie Zhu; Beifen Shen
[Expression of recombinant human stem cell factor in insect cells].
Wei sheng wu xue bao = Acta microbiologica Sinica 2000;40(1):44-9.
1997: J Wang; Y Zhu; C Lai; S Xue; H Ma; Beifen Shen
[Transfer and expression of rh-SCF gene in human hematopoietic stem/progenitor cells].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 1997;18(2):87-90.