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Danny Shen

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Zhican Wang; Connie L Davis; Leslie J Dickmann; David L Eaton; Johanna W Lampe; Yvonne S Lin; Emma-Jane Poulton; Danny D Shen; Margaret C Shuhart; Kenneth E Thummel
Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: implications for drug-induced osteomalacia.
Mary F Hebert; Menachem Miodovnik; Danny D Shen; Kenneth E Thummel; Jason G Umans; Songmao Zheng; Connie L Davis; Karen Hays; Thomas R Easterling
Interpreting tacrolimus concentrations during pregnancy and postpartum.
Songmao Zheng; Justina C Calamia; Connie L Davis; Mary F Hebert; Yvonne S Lin; Danny D Shen; Yoshihisa Shitara; Yasar Tasnif; Kenneth E Thummel
CYP3A5 gene variation influences cyclosporine A metabolite formation and renal cyclosporine disposition.

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2013: Zhican Wang; Connie L Davis; Leslie J Dickmann; David L Eaton; Johanna W Lampe; Yvonne S Lin; Emma-Jane Poulton; Danny D Shen; Margaret C Shuhart; Kenneth E Thummel
Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: implications for drug-induced osteomalacia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(5):1101-16.
2013: Mary F Hebert; Menachem Miodovnik; Danny D Shen; Kenneth E Thummel; Jason G Umans; Songmao Zheng; Connie L Davis; Karen Hays; Thomas R Easterling
Interpreting tacrolimus concentrations during pregnancy and postpartum.
Transplantation 2013;95(7):908-15.
2013: Songmao Zheng; Justina C Calamia; Connie L Davis; Mary F Hebert; Yvonne S Lin; Danny D Shen; Yoshihisa Shitara; Yasar Tasnif; Kenneth E Thummel
CYP3A5 gene variation influences cyclosporine A metabolite formation and renal cyclosporine disposition.
Transplantation 2013;95(6):821-7.
2012: S Zheng; Justina C Calamia; C L Davis; Mary F Hebert; Yvonne S Lin; Danny D Shen; Y Shitara; Y Tasnif; Kenneth E Thummel
Measurement and compartmental modeling of the effect of CYP3A5 gene variation on systemic and intrarenal tacrolimus disposition.
Clinical pharmacology and therapeutics 2012;92(6):737-45.
2012: Songmao Zheng; Justina C Calamia; Connie L Davis; Thomas R Easterling; Menachem Miodovnik; Danny D Shen; Kenneth E Thummel; Jason G Umans; Mary F Hebert
Pharmacokinetics of tacrolimus during pregnancy.
Therapeutic drug monitoring 2012;34(6):660-70.
2012: Griffith A Bell; Elizabeth D Kantor; Johanna W Lampe; Danny D Shen; Emily White
Use of glucosamine and chondroitin in relation to mortality.
European journal of epidemiology 2012;27(8):593-603.
2010: Sara Eyal; Thomas R Easterling; Darcy Carr; Jason G Umans; Menachem Miodovnik; Gary D V Hankins; Shannon M Clark; Linda Risler; Joanne Wang; Edward J Kelly; Danny D Shen; Mary F Hebert
Pharmacokinetics of metformin during pregnancy.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(5):833-40.
2009: David H Salinger; Danny D Shen; Kenneth Thummel; Paolo Vicini; Ann K Wittkowsky; David L Veenstra
Pharmacogenomic trial design: use of a PK/PD model to explore warfarin dosing interventions through clinical trial simulation.
Pharmacogenetics and genomics 2009;19(12):965-71.
2009: Meng Li; Marilee A Andrew; Joanne Wang; David H Salinger; Paolo Vicini; Richard W Grady; Brian Phillips; Danny D Shen; Gail D Anderson
Effects of cranberry juice on pharmacokinetics of beta-lactam antibiotics following oral administration.
Antimicrobial agents and chemotherapy 2009;53(7):2725-32.
2009: Erica L Woodahl; Matthew H Crouthamel; Tot Bui; Danny D Shen; Rodney J Y Ho
MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents.
Cancer chemotherapy and pharmacology 2009;64(1):183-8.
2009: M L Buchanan; T R Easterling; D B Carr; Danny D Shen; Linda Risler; Wendel L Nelson; Donald R Mattison; Mary F Hebert
Clonidine pharmacokinetics in pregnancy.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(4):702-5.
2007: Gail D Anderson; Danny D Shen
Where is the evidence that p-glycoprotein limits brain uptake of antiepileptic drug and contributes to drug resistance in epilepsy?
Epilepsia 2007;48(12):2372-4.
2007: Yu Chen; Gwendolyn E Kuehl; Jeannette Bigler; Christine F Rimorin; Yvonne Schwarz; Danny D Shen; Johanna W Lampe
UGT1A6 polymorphism and salicylic acid glucuronidation following aspirin.
Pharmacogenetics and genomics 2007;17(8):571-9.
2007: Weili Huang; Thomas F Kalhorn; Mark Baillie; Danny D Shen; Kenneth E Thummel
Determination of free and total cortisol in plasma and urine by liquid chromatography-tandem mass spectrometry.
Therapeutic drug monitoring 2007;29(2):215-24.
2006: David H Salinger; Jeannine S McCune; Aaron G Ren; Danny D Shen; John T Slattery; Brian Phillips; George B McDonald; Paolo Vicini
Real-time dose adjustment of cyclophosphamide in a preparative regimen for hematopoietic cell transplant: a Bayesian pharmacokinetic approach.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(16):4888-98.
2006: Douglas O Johns; William Daniell; Danny D Shen; David A Kalman; Russell L Dills; Michael S Morgan
Ethanol-induced increase in the metabolic clearance of 1,1,1-trichloroethane in human volunteers.
Toxicological sciences : an official journal of the Society of Toxicology 2006;92(1):61-70.
2006: Bojan Lalovic; Evan D Kharasch; Christine Hoffer; Linda Risler; Lee-Yuan Liu-Chen; Danny D Shen
Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites.
Clinical pharmacology and therapeutics 2006;79(5):461-79.
2006: Yang Dai; Mary F Hebert; Nina Isoherranen; Connie L Davis; Christopher Marsh; Danny D Shen; Kenneth E Thummel
Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(5):836-47.
2006: Meng Li; Gail D Anderson; Brian R Phillips; Wei Kong; Danny D Shen; Joanne Wang
Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(4):547-55.
2005: Erica L Woodahl; Ziping Yang; Tot Bui; Danny D Shen; Rodney J Y Ho
MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells.
AIDS (London, England) 2005;19(15):1617-25.
2005: Thomas M Burbacher; Danny D Shen; Noelle Liberato; Kimberly S Grant; Elsa Cernichiari; Thomas Clarkson
Comparison of blood and brain mercury levels in infant monkeys exposed to methylmercury or vaccines containing thimerosal.
Environmental health perspectives 2005;113(8):1015-21.
2005: Jeannine S McCune; Linda Risler; Brian R Phillips; Kenneth E Thummel; David K Blough; Danny D Shen
Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):1074-81.
2004: Danny D Shen; Alan A Artru; Kimberly K Adkison
Principles and applicability of CSF sampling for the assessment of CNS drug delivery and pharmacodynamics.
Advanced drug delivery reviews 2004;56(12):1825-57.
2004: Thomas M Burbacher; Kimberly S Grant; Danny D Shen; Elizabeth A Sheppard; Doris Damian; Stephen Ellis; Noelle Liberato
Chronic maternal methanol inhalation in nonhuman primates (Macaca fascicularis): reproductive performance and birth outcome.
Neurotoxicology and teratology 2004;26(5):639-50.
2004: Erica L Woodahl; Ziping Yang; Tot Bui; Danny D Shen; Rodney J Y Ho
Multidrug resistance gene G1199A polymorphism alters efflux transport activity of P-glycoprotein.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1199-207.
2004: T Andrew Bowdle; Aaron Even; Danny D Shen; Meghan Swardstrom
Methadone for the induction of anesthesia: plasma histamine concentration, arterial blood pressure, and heart rate.
Anesthesia and analgesia 2004;98(6):1692-7, table of contents.
2004: Lisa A McConnachie; Miklos Bodor; Kris Kowdley; Adam Levy; Bruce Tung; Kenneth E Thummel; Brian Phillips; Manoj Bajpai; Victor Chi; Joel D Esmay; Danny D Shen; Rodney J Y Ho
Human liver cytochrome P450 2D6 genotype, full-length messenger ribonucleic acid, and activity assessed with a novel cytochrome P450 2D6 substrate.
Clinical pharmacology and therapeutics 2004;75(4):282-97.
2004: Bojan Lalovic; Brian Phillips; Linda L Risler; William N Howald; Danny D Shen
Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(4):447-54.
2004: Ziping Yang; Micha Horn; Joanne Wang; Danny D Shen; Rodney J Y Ho
Development and characterization of a recombinant Madin-Darby canine kidney cell line that expresses rat multidrug resistance-associated protein 1 (rMRP1).
AAPS pharmSci 2004;6(1):E8.
2004: Thomas M Burbacher; Danny D Shen; Bojan Lalovic; Kimberly S Grant; Elizabeth A Sheppard; Doris Damian; Stephen Ellis; Noelle Liberato
Chronic maternal methanol inhalation in nonhuman primates (Macaca fascicularis): exposure and toxicokinetics prior to and during pregnancy.
Neurotoxicology and teratology 2004;26(2):201-21.
2004: Ziping Yang; Micha Horn; Joanne Wang; Danny D Shen; Rodney J Y Ho
Development and characterization of a recombinant madin-darby canine kidney cell line that expresses rat multidrug resistance-associated protein 1 (rMRP1).
The AAPS journal 2004;6(1):77-85.
2004: Lisa A McConnachie; Miklos Bodor; Brian Phillips; Edward J Kelly; Danny D Shen; Rodney J Y Ho
An RT-PCR-based strategy to estimate full-length CYP2D6 mRNA copy number.
Genetic testing 2004;8(3):313-8.
2004: John P Gibbs; Moji Christianah Adeyeye; Ziping Yang; Danny D Shen
Valproic acid uptake by bovine brain microvessel endothelial cells: role of active efflux transport.
Epilepsy research 2004;58(1):53-66.
2003: Lisa A McConnachie; Brian Phillips; Manoj Bajpai; Danny D Shen; Rodney J Y Ho
Only truncated, not complete cytochrome p450 2D6 RNA transcript and no detectable enzyme activity are expressed in human lymphocytes.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(9):1103-7.
2003: Christopher M Bernards; Danny D Shen; Emily S Sterling; Jason E Adkins; Linda Risler; Brian Phillips; Wolfgang Ummenhofer
Epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidural opioids (part 2): effect of epinephrine.
Anesthesiology 2003;99(2):466-75.
2003: Christopher M Bernards; Danny D Shen; Emily S Sterling; Jason E Adkins; Linda Risler; Brian Phillips; Wolfgang Ummenhofer
Epidural, cerebrospinal fluid, and plasma pharmacokinetics of epidural opioids (part 1): differences among opioids.
Anesthesiology 2003;99(2):455-65.
2003: Anne M Lynn; Mary-Kay Nespeca; Susan L Bratton; Danny D Shen
Ventilatory effects of morphine infusions in cyanotic versus acyanotic infants after thoracotomy.
Paediatric anaesthesia 2003;13(1):12-7.
2002: Ziping Yang; Erica L Woodahl; XY Wang; Tot Bui; Danny D Shen; Rodney J Y Ho
Semi-quantitative RT-PCR method to estimate full-length mRNA levels of the multidrug resistance gene.
BioTechniques 2002;33(1):196, 198, 200 passim.
2002: R C Sachdeo; S K Sachdeo; René H Levy; Anthony J Streeter; FE Bishop; K L Kunze; Gary Mather; Lorin K Roskos; Danny D Shen; K E Thummel; William F Trager; Christopher Curtin; Dennis R Doose; LG Gisclon; Meir Bialer
Topiramate and phenytoin pharmacokinetics during repetitive monotherapy and combination therapy to epileptic patients.
Epilepsia 2002;43(7):691-6.
2002: Ziping Yang; Cheryl S W Li; Danny D Shen; Rodney J Y Ho
Cloning and characterization of the rat multidrug resistance-associated protein 1.
AAPS pharmSci 2002;4(3):E15.
2001: Yvonne S Lin; Graham F Lockwood; Martin A Graham; W R Brian; C M Loi; M R Dobrinska; Danny D Shen; Paul B Watkins; G R Wilkinson; Evan D Kharasch; Kenneth E Thummel
In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration.
Pharmacogenetics 2001;11(9):781-91.
2001: CR Bethune; Christopher M Bernards; T Bui-Nguyen; Danny D Shen; Rodney J Y Ho
The role of drug-lipid interactions on the disposition of liposome-formulated opioid analgesics in vitro and in vivo.
Anesthesia and analgesia 2001;93(4):928-33.
2000: J L Scism; K M Powers; Alan A Artru; L Lewis; Danny D Shen
Probenecid-inhibitable efflux transport of valproic acid in the brain parenchymal cells of rabbits: a microdialysis study.
Brain research 2000;884(1--2):77-86.
2000: Mary F Paine; Connie L Davis; Danny D Shen; Christopher L Marsh; Vidmantas A Raisys; Kenneth E Thummel
Can oral midazolam predict oral cyclosporine disposition?
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;12(1):51-62.
2000: M K Erjavec; BA Coda; Q Nguyen; G Donaldson; Linda Risler; Danny D Shen
Morphine-fluoxetine interactions in healthy volunteers: analgesia and side effects.
Journal of clinical pharmacology 2000;40(11):1286-95.
2000: Anne M Lynn; Mary-Kay Nespeca; Susan L Bratton; Danny D Shen
Intravenous morphine in postoperative infants: intermittent bolus dosing versus targeted continuous infusions.
Pain 2000;88(1):89-95.
2000: T Nishiyama; Rodney J Y Ho; Danny D Shen; Tony L Yaksh
The effects of intrathecal morphine encapsulated in L- and D-dipalmitoylphosphatidyl choline liposomes on acute nociception in rats.
Anesthesia and analgesia 2000;91(2):423-8.
2000: S Madani; William N Howald; RF Lawrence; Danny D Shen
Analysis of hydroxylated and N-dealkylated metabolites of terfenadine in microsomal incubates by liquid chromatography--mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 2000;741(2):145-53.
2000: Larry A Bauer; John R Horn; M S Maxon; Thomas R Easterling; Danny D Shen; D Eugene Strandness
Effect of metoprolol and verapamil administered separately and concurrently after single doses on liver blood flow and drug disposition.
Journal of clinical pharmacology 2000;40(5):533-43.
2000: MA Gibbs; M T Baillie; Danny D Shen; Kent L Kunze; Kenneth E Thummel
Persistent inhibition of CYP3A4 by ketoconazole in modified Caco-2 cells.
Pharmaceutical research 2000;17(3):299-305.
2000: Wolfgang Ummenhofer; RH Arends; Danny D Shen; Christopher M Bernards
Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil, and sufentanil.
Anesthesiology 2000;92(3):739-53.
2000: L A Scarlett; S Madani; Danny D Shen; Rodney J Y Ho
Development and characterization of a rapid and comprehensive genotyping assay to detect the most common variants in cytochrome P450 2D6.
Pharmaceutical research 2000;17(2):242-6.
2000: KL Koszdin; Danny D Shen; Christopher M Bernards
Spinal cord bioavailability of methylprednisolone after intravenous and intrathecal administration: the role of P-glycoprotein.
Anesthesiology 2000;92(1):156-63.
1999: S Madani; Mary F Paine; L Lewis; Kenneth E Thummel; Danny D Shen
Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines.
Pharmaceutical research 1999;16(8):1199-205.
1999: D Janet Pavlin; RH Arends; HC Gunn; Gail A Van Norman; ME Koerschgen; Danny D Shen
Optimal propofol-alfentanil combinations for supplementing nitrous oxide for outpatient surgery.
Anesthesiology 1999;91(1):97-108.
1999: Jeannine M Fisher; S A Wrighton; Justina C Calamia; Danny D Shen; Kent L Kunze; Kenneth E Thummel
Midazolam metabolism by modified Caco-2 monolayers: effects of extracellular protein binding.
The Journal of pharmacology and experimental therapeutics 1999;289(2):1143-50.
1999: Jeannine M Fisher; S A Wrighton; Paul B Watkins; Phyllissa Schmiedlin-Ren; Justina C Calamia; Danny D Shen; Kent L Kunze; Kenneth E Thummel
First-pass midazolam metabolism catalyzed by 1alpha,25-dihydroxy vitamin D3-modified Caco-2 cell monolayers.
The Journal of pharmacology and experimental therapeutics 1999;289(2):1134-42.
1999: MA Gibbs; Kenneth E Thummel; Danny D Shen; Kent L Kunze
Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(2):180-7.
1999: Crispin H Pierce; Thomas A Lewandowski; Russell L Dills; Michael S Morgan; M A Wessels; Danny D Shen; David A Kalman
A comparison of 1H8- and 2H8-toluene toxicokinetics in men.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(1):93-108.
1999: BA Coda; M C Brown; Linda Risler; Karen L Syrjala; Danny D Shen
Equivalent analgesia and side effects during epidural and pharmacokinetically tailored intravenous infusion with matching plasma alfentanil concentration.
Anesthesiology 1999;90(1):98-108.
1998: RH Arends; T G Hayashi; T J Luger; Danny D Shen
Cotreatment with racemic fenfluramine inhibits the development of tolerance to morphine analgesia in rats.
The Journal of pharmacology and experimental therapeutics 1998;286(2):585-92.
1998: Anne M Lynn; Mary-Kay Nespeca; Susan L Bratton; S G Strauss; Danny D Shen
Clearance of morphine in postoperative infants during intravenous infusion: the influence of age and surgery.
Anesthesia and analgesia 1998;86(5):958-63.
1997: Mary F Paine; M Khalighi; Jeannine M Fisher; Danny D Shen; Kent L Kunze; Christopher L Marsh; J D Perkins; Kenneth E Thummel
Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1552-62.
1997: J L Scism; K M Powers; Alan A Artru; A C Chambers; L Lewis; K K Adkison; Thomas F Kalhorn; Danny D Shen
Effects of probenecid on brain-cerebrospinal fluid-blood distribution kinetics of E-Delta 2-valproic acid in rabbits.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(12):1337-46.
1997: BA Coda; B O'Sullivan; G Donaldson; S Bohl; C Richard Chapman; Danny D Shen
Comparative efficacy of patient-controlled administration of morphine, hydromorphone, or sufentanil for the treatment of oral mucositis pain following bone marrow transplantation.
Pain 1997;72(3):333-46.
1997: Russell L Dills; Danny D Shen
Methods to reduce background interferences in electron-capture gas chromatographic analysis of valproic acid and its unsaturated metabolites after derivatization with pentafluorobenzyl bromide.
Journal of chromatography. B, Biomedical sciences and applications 1997;690(1-2):139-52.
1996: M Bajpai; Lorin K Roskos; Danny D Shen; René H Levy
Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(12):1401-3.
1996: Mary F Paine; Danny D Shen; Kent L Kunze; James D Perkins; Christopher L Marsh; John P McVicar; D M Barr; B S Gillies; Kenneth E Thummel
First-pass metabolism of midazolam by the human intestine.
Clinical pharmacology and therapeutics 1996;60(1):14-24.
1996: Crispin H Pierce; Russell L Dills; Michael S Morgan; G L Nothstein; Danny D Shen; David A Kalman
Interindividual differences in 2H8-toluene toxicokinetics assessed by semiempirical physiologically based model.
Toxicology and applied pharmacology 1996;139(1):49-61.
1996: Kenneth E Thummel; D O'Shea; Mary F Paine; Danny D Shen; Kent L Kunze; James D Perkins; G R Wilkinson
Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.
Clinical pharmacology and therapeutics 1996;59(5):491-502.
1996: Kohji Naora; N Ichikawa; N Nishimura; H Hirano; Danny D Shen; K Iwamoto
Saturable transport of valproic acid in rat choroid plexus in vitro.
Journal of pharmaceutical sciences 1996;85(4):423-6.
1996: K D Adkison; Karen M Powers; Alan A Artru; Danny D Shen
Effect of para-aminohippurate on the efflux of valproic acid from the central nervous system of the rabbit.
Epilepsy research 1996;23(2):95-104.
1996: K D Adkison; Danny D Shen
Uptake of valproic acid into rat brain is mediated by a medium-chain fatty acid transporter.
The Journal of pharmacology and experimental therapeutics 1996;276(3):1189-200.
1996: D Janet Pavlin; BA Coda; Danny D Shen; J Tschanz; Q Nguyen; R Schaffer; G Donaldson; Robert C Jacobson; C Richard Chapman
Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers.
Anesthesiology 1996;84(1):23-37.
1995: DS Mautz; Danny D Shen; Wendel L Nelson
Regioselectivity and enantioselectivity of metoprolol oxidation by two variants of cDNA-expressed P4502D6.
Pharmaceutical research 1995;12(12):2053-6.
1995: Kohji Naora; Danny D Shen
Mechanism of valproic acid uptake by isolated rat brain microvessels.
Epilepsy research 1995;22(2):97-106.
1995: BA Coda; M C Brown; R L Schaffer; G Donaldson; Danny D Shen
A pharmacokinetic approach to resolving spinal and systemic contributions to epidural alfentanil analgesia and side-effects.
Pain 1995;62(3):329-37.
1995: K D Adkison; George A Ojemann; R L Rapport; Russell L Dills; Danny D Shen
Distribution of unsaturated metabolites of valproate in human and rat brain--pharmacologic relevance?
Epilepsia 1995;36(8):772-82.
1995: E D Agura; M C Brown; R Schaffer; G Donaldson; Danny D Shen
Antiemetic efficacy and pharmacokinetics of intravenous ondansetron infusion during chemotherapy conditioning for bone marrow transplant.
Bone marrow transplantation 1995;16(2):213-22.
1995: DS Mautz; Wendel L Nelson; Danny D Shen
Regioselective and stereoselective oxidation of metoprolol and bufuralol catalyzed by microsomes containing cDNA-expressed human P4502D6.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(4):513-7.
1995: K D Adkison; Alan A Artru; Karen M Powers; David Nochlin; Danny D Shen
Role of choroid plexus epithelium in the removal of valproic acid from the central nervous system.
Epilepsy research 1995;20(3):185-92.
1994: BA Coda; M C Brown; R Schaffer; G Donaldson; R Jacobson; B Hautman; Danny D Shen
Pharmacology of epidural fentanyl, alfentanil, and sufentanil in volunteers.
Anesthesiology 1994;81(5):1149-61.
1994: Kenneth E Thummel; Danny D Shen; T D Podoll; Kent L Kunze; William F Trager; C E Bacchi; Christopher L Marsh; John P McVicar; D M Barr; James D Perkins
Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation.
The Journal of pharmacology and experimental therapeutics 1994;271(1):557-66.
1994: Kenneth E Thummel; Danny D Shen; T D Podoll; Kent L Kunze; William F Trager; P S Hartwell; V A Raisys; Christopher L Marsh; John P McVicar; D M Barr
Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients.
The Journal of pharmacology and experimental therapeutics 1994;271(1):549-56.
1994: Alan A Artru; K D Adkinson; Karen M Powers; Danny D Shen
Clearance of valproic acid from cerebrospinal fluid in anesthetized rabbit.
Journal of neurosurgical anesthesiology 1994;6(3):193-200.
1994: R H Arends; K Zhang; René H Levy; Thomas A Baillie; Danny D Shen
Stereoselective pharmacokinetics of stiripentol: an explanation for the development of tolerance to anticonvulsant effect.
Epilepsy research 1994;18(2):91-6.
1994: P H Marathe; Danny D Shen; W L Nelson
Metabolic kinetics of pseudoracemic propranolol in human liver microsomes. Enantioselectivity and quinidine inhibition.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(2):237-47.
1994: K D Adkison; Alan A Artru; Karen M Powers; Danny D Shen
Contribution of probenecid-sensitive anion transport processes at the brain capillary endothelium and choroid plexus to the efficient efflux of valproic acid from the central nervous system.
The Journal of pharmacology and experimental therapeutics 1994;268(2):797-805.
1993: M Kim; Danny D Shen; A C Eddy; Wendel L Nelson; Lorin K Roskos
Inhibition of the enantioselective oxidative metabolism of metoprolol by verapamil in human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(2):309-17.
1992: Danny D Shen; René H Levy; J L Savitch; A V Boddy; F Tombret; F Lepage
Comparative anticonvulsant potency and pharmacokinetics of (+)-and (-)-enantiomers of stiripentol.
Epilepsy research 1992;12(1):29-36.
1992: Danny D Shen; George A Ojemann; R L Rapport; Russell L Dills; P N Friel; René H Levy
Low and variable presence of valproic acid in human brain.
Neurology 1992;42(3 Pt 1):582-5.
1991: P H Marathe; Danny D Shen; Alan A Artru; T Andrew Bowdle
Effect of serum protein binding on the entry of lidocaine into brain and cerebrospinal fluid in dogs.
Anesthesiology 1991;75(5):804-12.
1991: S S Murthy; Wendel L Nelson; Danny D Shen; J M Power; C M Cahill; A J McLean
Pharmacokinetic interaction between verapamil and metoprolol in the dog. Stereochemical aspects.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(6):1093-100.
1991: R L Semmes; Danny D Shen
Comparative pharmacodynamics and brain distribution of E-delta 2-valproate and valproate in rats.
Epilepsia 1991;32(2):232-41.
1990: Danny D Shen; René H Levy; M J Moor; J L Savitch
Efficacy of stiripentol in the intravenous pentylenetetrazol infusion seizure model in the rat.
Epilepsy research 1990;7(1):40-8.
1990: R L Semmes; Danny D Shen
Nonlinear binding of valproic acid (VPA) and E-delta 2-valproic acid to rat plasma proteins.
Pharmaceutical research 1990;7(5):461-7.
1990: R L Semmes; Danny D Shen
A reversible clearance model for the enterohepatic circulation of drug and conjugate metabolite pair.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(1):80-7.
1989: S Laganière; E Kwong; Danny D Shen
Stereoselective high-performance liquid chromatographic assay for propranolol enantiomers in serum.
Journal of chromatography 1989;488(2):407-16.
1988: R L Semmes; Danny D Shen
Capillary gas chromatographic assay for valproic acid and its 2-desaturated metabolite in brain and plasma.
Journal of chromatography 1988;432():185-97.
1988: E C Kwong; S Laganière; J L Savitch; Wendel L Nelson; Danny D Shen
Alteration in the disposition and metabolism of S(-)-propranolol in rats with active respiratory viral infection.
Life sciences 1988;42(12):1245-52.
1987: E C Kwong; Danny D Shen
Versatile isocratic high-performance liquid chromatographic assay for propranolol and its basic, neutral and acidic metabolites in biological fluids.
Journal of chromatography 1987;414(2):365-79.