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Dong-Ming Shen

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Thomas H Graham; Jeffrey J Hale; Huaibing He; Michael E Lassman; Xiaohua Li; JeanMarie Lisnock; Wensheng Liu; Shirly Pinto; Mikhail Reibarkh; Zhu Shen; Xinchun Tong; Elaine C Tung; Andreas Verras; Judyann Wiltsie; Jianying Xiao; Dan Xie; Suoyu Xu; Urmi R Bhatt; Kelly Bleasby; Qing Chen; Margarita Garcia-Calvo; Wayne M Geissler; Judith N Gorski; Dong-Ming Shen
A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes.
Thomas H Graham; Jeffrey J Hale; Huaibing He; Michael E Lassman; Xiaohua Li; JeanMarie Lisnock; Wensheng Liu; Shirly Pinto; Iyassu K Sebhat; Zhu Shen; Xinchun Tong; Elaine C Tung; Andreas Verras; Judyann Wiltsie; Jianying Xiao; Dan Xie; Yusheng Xiong; Suoyu Xu; Urmi R Bhatt; Kelly Bleasby; Qing Chen; Margarita Garcia-Calvo; Wayne M Geissler; Judith N Gorski; Dong-Ming Shen
A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation.
Cristiano G Ponte; william Schmalhofer; Tarak Shah; Dong-Ming Shen; Min Shu; Andra Stevenson; Guilherme Suarez-Kurtz; Sylvie Sur; Gregory J Kaczorowski; Laszlo Kiss; Owen B McManus; Ravi Nargund; Ge Dai; James B Doherty; Maria L Garcia
Selective, direct activation of high-conductance, calcium-activated potassium channels causes smooth muscle relaxation.

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All Publications

2012: Thomas H Graham; Jeffrey J Hale; Huaibing He; Michael E Lassman; Xiaohua Li; JeanMarie Lisnock; Wensheng Liu; Shirly Pinto; Mikhail Reibarkh; Zhu Shen; Xinchun Tong; Elaine C Tung; Andreas Verras; Judyann Wiltsie; Jianying Xiao; Dan Xie; Suoyu Xu; Urmi R Bhatt; Kelly Bleasby; Qing Chen; Margarita Garcia-Calvo; Wayne M Geissler; Judith N Gorski; Dong-Ming Shen
A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes.
Bioorganic & medicinal chemistry letters 2012;22(8):2818-22.
2012: Thomas H Graham; Jeffrey J Hale; Huaibing He; Michael E Lassman; Xiaohua Li; JeanMarie Lisnock; Wensheng Liu; Shirly Pinto; Iyassu K Sebhat; Zhu Shen; Xinchun Tong; Elaine C Tung; Andreas Verras; Judyann Wiltsie; Jianying Xiao; Dan Xie; Yusheng Xiong; Suoyu Xu; Urmi R Bhatt; Kelly Bleasby; Qing Chen; Margarita Garcia-Calvo; Wayne M Geissler; Judith N Gorski; Dong-Ming Shen
A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation.
Bioorganic & medicinal chemistry letters 2012;22(8):2811-7.
2012: Cristiano G Ponte; william Schmalhofer; Tarak Shah; Dong-Ming Shen; Min Shu; Andra Stevenson; Guilherme Suarez-Kurtz; Sylvie Sur; Gregory J Kaczorowski; Laszlo Kiss; Owen B McManus; Ravi Nargund; Ge Dai; James B Doherty; Maria L Garcia
Selective, direct activation of high-conductance, calcium-activated potassium channels causes smooth muscle relaxation.
Molecular pharmacology 2012;81(4):567-77.
2012: Zhicai Wu; Dan Xie; Suoyu Xu; Cangming Yang; Zhu Shen; Ranabir Sinharoy; James R Tata; Xinchun Tong; Andreas Verras; Urmi R Bhatt; Kelly Bleasby; Renee M Chabin; Qing Chen; Steven L Colletti; Margarita M Garcia-Calvo; Thomas H Graham; Jeffrey J Hale; Mike E Lassman; Shirly Pinto; Dong-Ming Shen
Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(4):1727-30.
2012: Hong Shen; Zhu Shen; Ranabir SinhaRoy; Xinchun Tong; Andreas Verras; Judyann Wiltsie; Dan Xie; Suoyu Xu; Urmi R Bhatt; Renee M Chabin; Qing Chen; Fa-Xiang Ding; Margarita M Garcia-Calvo; Wayne Geissler; Judith N Gorski; Jeffrey J Hale; Jinlong Jiang; Mike E Lassman; Beth Ann Murphy; Shirly Pinto; Dong-Ming Shen
Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(4):1550-6.
2012: Zhicai Wu; Dan Xie; Yusheng Xiong; Suoyu Xu; Cangming Yang; Urmi R Bhatt; Renee M Chabin; Qing Chen; Zhe Feng; Margarita M Garcia-Calvo; Wayne Geissler; Jeffrey J Hale; Mike E Lassman; Matthew Lombardo; Shirly Pinto; Dong-Ming Shen; Zhu Shen; Ranabir Sinharoy; James R Tata; Xinchun Tong; Andreas Verras; Steven L Colletti
Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine.
Bioorganic & medicinal chemistry letters 2012;22(4):1774-8.
2011: Thomas H Graham; Wensheng Liu; Dong-Ming Shen
A method for the reductive scission of heterocyclic thioethers.
Organic letters 2011;13(23):6232-5.
2011: J Mu; Emma R Parmee; Sajjad A Qureshi; Dong-Ming Shen; Xiaolan Shen; R Sinharoy; J Woods; M Wright; Edward J Brady; M L Candelore; Qing Dallas-Yang; Guoqiang Jiang; Zhihua Li; Franklin Liu; K Lu; Fengqi Zhang; L Zhu; E Zycband; Bei B Zhang
Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice.
Diabetologia 2011;54(9):2381-91.
2011: Dong-Ming Shen; Songnian Lin; Emma R Parmee
A survey of small molecule glucagon receptor antagonists from recent patents (2006 - 2010).
Expert opinion on therapeutic patents 2011;21(8):1211-40.
2011: Hong Shen; Fa-Xiang Ding; Changyou Zhou; Yusheng Xiong; Andreas Verras; Renee M Chabin; Suoyu Xu; Xinchun Tong; Dan Xie; Michael E Lassman; Urmi R Bhatt; Margarita M Garcia-Calvo; Wayne M Geissler; Zhu Shen; Dunlu Chen; Ranabir Sinharoy; Jeffrey J Hale; James R Tata; Shirly Pinto; Dong-Ming Shen; Steven L Colletti
Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(5):1299-305.
2011: Dong-Ming Shen; Edward J Brady; Mari Rios Candelore; Qing Dallas-Yang; Victor D H Ding; William P Feeney; Guoquiang Jiang; Margaret E McCann; Steve Mock; Sajjad A Qureshi; Richard Saperstein; Xiaolan Shen; Xinchun Tong; Laurie M Tota; Michael J Wright; Xiaodong Yang; Song Zheng; Kevin Chapman; Bei B Zhang; James R Tata; Emma R Parmee
Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core.
Bioorganic & medicinal chemistry letters 2011;21(1):76-81.
2010: Xuemei Zhao; Katie Southwick; Helene L Cardasis; Yi Du; Michael E Lassman; Dan Xie; Mohamed El-Sherbeini; Wayne M Geissler; KellyAnn D Pryor; Andreas Verras; Margarita Garcia-Calvo; Dong-Ming Shen; Nathan A Yates; Shirly Pinto; Ronald C Hendrickon
Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase.
Proteomics 2010;10(15):2882-6.
2005: Dong-Ming Shen; Fengqi Zhang; Edward J Brady; Mari Rios Candelore; Qing Dallas-Yang; Victor D H Ding; Jasminka Dragovic; William P Feeney; Guoquiang Jiang; Peggy E McCann; Steve Mock; Sajjad A Qureshi; Richard Saperstein; Xiaolan Shen; Constantin Tamvakopoulos; Xinchun Tong; Laurie M Tota; Michael J Wright; Xiaodong Yang; Song Zheng; Kevin Chapman; Bei B Zhang; James R Tata; Emma R Parmee
Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists.
Bioorganic & medicinal chemistry letters 2005;15(20):4564-9.
2004: Min Shu; Jennifer L Loebach; Kerry A Parker; Sander G Mills; Kevin Chapman; Dong-Ming Shen; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Jerry Di Salvo; Kathryn Lyons; James V Pivnichny; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.
Bioorganic & medicinal chemistry letters 2004;14(4):947-52.
2004: Dong-Ming Shen; Min Shu; Christopher A Willoughby; Shrenik Shah; Christopher L Lynch; Jeffrey J Hale; Sander G Mills; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Kathryn Lyons; James V Pivnichny; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds.
Bioorganic & medicinal chemistry letters 2004;14(4):941-5.
2004: Dong-Ming Shen; Min Shu; Sander G Mills; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains.
Bioorganic & medicinal chemistry letters 2004;14(4):935-9.
2003: Christopher L Lynch; Jeffrey J Hale; Richard J Budhu; Amy L Gentry; Paul E Finke; Charles G Caldwell; Sander G Mills; Malcolm MacCoss; Dong-Ming Shen; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity.
Organic letters 2003;5(14):2473-5.
2001: N Yates; D Wislocki; A Roberts; Scott Berk; T Klatt; Dong-Ming Shen; Christopher A Willoughby; Keith G Rosauer; Kevin Chapman; P Griffin
Mass spectrometry screening of combinatorial mixtures, correlation of measured and predicted electrospray ionization spectra.
Analytical chemistry 2001;73(13):2941-51.
2000: Dong-Ming Shen; M Shu; Kevin Chapman
Versatile and efficient solid-phase syntheses of pyrazoles and isoxazoles.
Organic letters 2000;2(18):2789-92.
1998: Susan P Rohrer; Elizabeth T Birzin; Ralph T Mosley; Scott Berk; Steven M Hutchins; Dong-Ming Shen; Y Xiong; Edward C Hayes; Rupa M Parmar; F Foor; Sudha Warrier Mitra; SJ Degrado; M Shu; J M Klopp; S J Cai; A Blake; Wanda W-S Chan; Alexander Pasternak; Lihu Yang; Arthur A Patchett; Roy G Smith; Kevin Chapman; James M Schaeffer
Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.
Science (New York, N.Y.) 1998;282(5389):737-40.