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Steven Block

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Publications

TOP 3
Jing Zhou; Volker Schweikhard; Steven M Block
Single-molecule studies of RNAPII elongation.
Daniel J Koslover; Robert Landick; Rachel A Mooney; Furqan M Fazal; Steven M Block
Binding and translocation of termination factor rho studied at the single-molecule level.
Kirsten L Frieda; Steven M Block
Direct observation of cotranscriptional folding in an adenine riboswitch.

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All Publications

2013: Jing Zhou; Volker Schweikhard; Steven M Block
Single-molecule studies of RNAPII elongation.
Biochimica et biophysica acta 2013;1829(1):29-38.
2012: Daniel J Koslover; Robert Landick; Rachel A Mooney; Furqan M Fazal; Steven M Block
Binding and translocation of termination factor rho studied at the single-molecule level.
Journal of molecular biology 2012;423(5):664-76.
2012: Kirsten L Frieda; Steven M Block
Direct observation of cotranscriptional folding in an adenine riboswitch.
Science (New York, N.Y.) 2012;338(6105):397-400.
2012: Matthew H Larson; Murali Palangat; Jing Zhou; Craig D Kaplan; Roger D Kornberg; Robert Landick; Steven M Block
Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(17):6555-60.
2012: Peter C Anthony; Steven M Block; Vincent B Chu; Sebastian Doniach; Adelene Y L Sim; Daniel Herschlag
Electrostatics of nucleic acid folding under conformational constraint.
Journal of the American Chemical Society 2012;134(10):4607-14.
2012: Peter C Anthony; Cuauhtémoc García-García; Christian F Perez; Steven M Block
Folding energy landscape of the thiamine pyrophosphate riboswitch aptamer.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(5):1485-9.
2011: Jing Zhou; Kook Sun Ha; Arthur La Porta; Robert Landick; Steven M Block
Applied force provides insight into transcriptional pausing and its modulation by transcription factor NusA.
Molecular cell 2011;44(4):635-46.
2011: Bason E Clancy; Steven S Rosenfeld; Johan O L Andreasson; William M Behnke-Parks; Steven M Block
A universal pathway for kinesin stepping.
Nature structural & molecular biology 2011;18(9):1020-7.
2011: Matthew H Larson; Robert Landick; Steven M Block
Single-molecule studies of RNA polymerase: one singular sensation, every little step it takes.
Molecular cell 2011;41(3):249-62.
2010: Kristina M Herbert; Jing Zhou; Rachel A Mooney; Arthur La Porta; Robert Landick; Steven M Block
E. coli NusG inhibits backtracking and accelerates pause-free transcription by promoting forward translocation of RNA polymerase.
Journal of molecular biology 2010;399(1):17-30.
2010: Braulio Gutiérrez-Medina; Johan O L Andreasson; William J Greenleaf; Arthur Laporta; Steven M Block
An optical apparatus for rotation and trapping.
Methods in enzymology 2010;475():377-404.
2009: Braulio Gutiérrez-Medina; Adrian N Fehr; Steven M Block
Direct measurements of kinesin torsional properties reveal flexible domains and occasional stalk reversals during stepping.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(40):17007-12.
2009: Adrian N Fehr; Braulio Gutiérrez-Medina; Charles L Asbury; Steven M Block
On the origin of kinesin limping.
Biophysical journal 2009;97(6):1663-70.
2009: Nicholas R Guydosh; Steven M Block
Direct observation of the binding state of the kinesin head to the microtubule.
Nature 2009;461(7260):125-8.
2008: Matthew H Larson; William J Greenleaf; Robert Landick; Steven M Block
Applied force reveals mechanistic and energetic details of transcription termination.
Cell 2008;132(6):971-82.
2008: Megan Valentine; Nicholas R Guydosh; Braulio Gutiérrez-Medina; Adrian N Fehr; Johan O Andreasson; Steven M Block
Precision steering of an optical trap by electro-optic deflection.
Optics letters 2008;33(6):599-601.
2008: William J Greenleaf; Kirsten L Frieda; Daniel A N Foster; Michael T Woodside; Steven M Block
Direct observation of hierarchical folding in single riboswitch aptamers.
Science (New York, N.Y.) 2008;319(5863):630-3.
2008: Adrian N Fehr; Charles L Asbury; Steven M Block
Kinesin steps do not alternate in size.
Biophysical journal 2008;94(3):L20-2.
2008: Kristina M Herbert; William J Greenleaf; Steven M Block
Single-molecule studies of RNA polymerase: motoring along.
Annual review of biochemistry 2008;77():149-76.
2007: Nicholas R Guydosh; Steven M Block
Not so lame after all: kinesin still walks with a hobbled head.
The Journal of general physiology 2007;130(5):441-4.
2007: Steven M Block
Kinesin motor mechanics: binding, stepping, tracking, gating, and limping.
Biophysical journal 2007;92(9):2986-95.
2007: Steven M Block; Matthew H Larson; William J Greenleaf; Kristina M Herbert; Nicholas R Guydosh; Peter C Anthony
Molecule by molecule, the physics and chemistry of life: SMB 2007.
Nature chemical biology 2007;3(4):193-7.
2007: William J Greenleaf; Michael T Woodside; Steven M Block
High-resolution, single-molecule measurements of biomolecular motion.
Annual review of biophysics and biomolecular structure 2007;36():171-90.
2006: Michael T Woodside; Peter C Anthony; William M Behnke-Parks; Kevan Larizadeh; Daniel Herschlag; Steven M Block
Direct measurement of the full, sequence-dependent folding landscape of a nucleic acid.
Science (New York, N.Y.) 2006;314(5801):1001-4.
2006: William J Greenleaf; Steven M Block
Single-molecule, motion-based DNA sequencing using RNA polymerase.
Science (New York, N.Y.) 2006;313(5788):801.
2006: Ravindra V Dalal; Matthew H Larson; Keir C Neuman; Jeff Gelles; Robert Landick; Steven M Block
Pulling on the nascent RNA during transcription does not alter kinetics of elongation or ubiquitous pausing.
Molecular cell 2006;23(2):231-9.
2006: Kristina M Herbert; Arthur La Porta; Becky J Wong; Rachel A Mooney; Keir C Neuman; Robert Landick; Steven M Block
Sequence-resolved detection of pausing by single RNA polymerase molecules.
Cell 2006;125(6):1083-94.
2006: Nicholas R Guydosh; Steven M Block
Backsteps induced by nucleotide analogs suggest the front head of kinesin is gated by strain.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(21):8054-9.
2006: Megan Valentine; Polly M Fordyce; Troy C Krzysiak; Susan P Gilbert; Steven M Block
Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro.
Nature cell biology 2006;8(5):470-6.
2006: Michael T Woodside; William M Behnke-Parks; Kevan Larizadeh; Kevin Travers; Daniel Herschlag; Steven M Block
Nanomechanical measurements of the sequence-dependent folding landscapes of single nucleic acid hairpins.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6190-5.
2006: Megan Valentine; Polly M Fordyce; Steven M Block
Eg5 steps it up!
Cell division 2006;1():31.
2005: Elio A Abbondanzieri; Joshua W Shaevitz; Steven M Block
Picocalorimetry of transcription by RNA polymerase.
Biophysical journal 2005;89(6):L61-3.
2005: Elio A Abbondanzieri; William J Greenleaf; Joshua W Shaevitz; Robert Landick; Steven M Block
Direct observation of base-pair stepping by RNA polymerase.
Nature 2005;438(7067):460-5.
2005: William J Greenleaf; Michael T Woodside; Elio A Abbondanzieri; Steven M Block
Passive all-optical force clamp for high-resolution laser trapping.
Physical review letters 2005;95(20):208102.
2005: Joshua W Shaevitz; Steven M Block; Mark J Schnitzer
Statistical kinetics of macromolecular dynamics.
Biophysical journal 2005;89(4):2277-85.
2005: Keir C Neuman; Elio A Abbondanzieri; Steven M Block
Measurement of the effective focal shift in an optical trap.
Optics letters 2005;30(11):1318-20.
2004: Matthew J Lang; Polly M Fordyce; Anita M Engh; Keir C Neuman; Steven M Block
Simultaneous, coincident optical trapping and single-molecule fluorescence.
Nature methods 2004;1(2):133-9.
2004: Keir C Neuman; Steven M Block
Optical trapping.
The Review of scientific instruments 2004;75(9):2787-809.
2004: Thomas T Perkins; Hung-Wen Li; Ravindra V Dalal; Jeff Gelles; Steven M Block
Forward and reverse motion of single RecBCD molecules on DNA.
Biophysical journal 2004;86(3):1640-8.
2003: Charles L Asbury; Adrian N Fehr; Steven M Block
Kinesin moves by an asymmetric hand-over-hand mechanism.
Science (New York, N.Y.) 2003;302(5653):2130-4.
2003: Joshua W Shaevitz; Elio A Abbondanzieri; Robert Landick; Steven M Block
Backtracking by single RNA polymerase molecules observed at near-base-pair resolution.
Nature 2003;426(6967):684-7.
2003: Keir C Neuman; Elio A Abbondanzieri; Robert Landick; Jeff Gelles; Steven M Block
Ubiquitous transcriptional pausing is independent of RNA polymerase backtracking.
Cell 2003;115(4):437-47.
2003: Thomas T Perkins; Ravindra V Dalal; Paul G Mitsis; Steven M Block
Sequence-dependent pausing of single lambda exonuclease molecules.
Science (New York, N.Y.) 2003;301(5641):1914-8.
2003: Steven S Rosenfeld; Polly M Fordyce; Geraldine M Jefferson; Peter H King; Steven M Block
Stepping and stretching. How kinesin uses internal strain to walk processively.
The Journal of biological chemistry 2003;278(20):18550-6.
2003: Steven M Block; Charles L Asbury; Joshua W Shaevitz; Matthew J Lang
Probing the kinesin reaction cycle with a 2D optical force clamp.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2351-6.
2003: Matthew J Lang; Polly M Fordyce; Steven M Block
Combined optical trapping and single-molecule fluorescence.
Journal of biology 2003;2(1):6.
2002: Matthew J Lang; Charles L Asbury; Joshua W Shaevitz; Steven M Block
An automated two-dimensional optical force clamp for single molecule studies.
Biophysical journal 2002;83(1):491-501.
2002: Liza J Davis; David J Odde; Steven M Block; Steven P Gross
The importance of lattice defects in katanin-mediated microtubule severing in vitro.
Biophysical journal 2002;82(6):2916-27.
2002: Steven P Gross; Michael A Welte; Steven M Block; Eric Wieschaus
Coordination of opposite-polarity microtubule motors.
The Journal of cell biology 2002;156(4):715-24.
2000: Mark J Schnitzer; K Visscher; Steven M Block
Force production by single kinesin motors.
Nature cell biology 2000;2(10):718-23.
2000: Steven P Gross; Michael A Welte; Steven M Block; Eric Wieschaus
Dynein-mediated cargo transport in vivo. A switch controls travel distance.
The Journal of cell biology 2000;148(5):945-56.
1999: K C Neuman; E H Chadd; G F Liou; K Bergman; Steven M Block
Characterization of photodamage to Escherichia coli in optical traps.
Biophysical journal 1999;77(5):2856-63.
1999: K Visscher; Mark J Schnitzer; Steven M Block
Single kinesin molecules studied with a molecular force clamp.
Nature 1999;400(6740):184-9.
1998: M D Wang; Mark J Schnitzer; H Yin; Robert Landick; Jeff Gelles; Steven M Block
Force and velocity measured for single molecules of RNA polymerase.
Science (New York, N.Y.) 1998;282(5390):902-7.
1998: Steven M Block
Kinesin: what gives?
Cell 1998;93(1):5-8.
1998: Steven M Block
Leading the procession: new insights into kinesin motors.
The Journal of cell biology 1998;140(6):1281-4.
1998: Michael A Welte; Steven P Gross; M Postner; Steven M Block; Eric Wieschaus
Developmental regulation of vesicle transport in Drosophila embryos: forces and kinetics.
Cell 1998;92(4):547-57.
1998: K Visscher; Steven M Block
Versatile optical traps with feedback control.
Methods in enzymology 1998;298():460-89.
1997: Mark J Schnitzer; Steven M Block
Kinesin hydrolyses one ATP per 8-nm step.
Nature 1997;388(6640):386-90.
1997: M D Wang; H Yin; Robert Landick; Jeff Gelles; Steven M Block
Stretching DNA with optical tweezers.
Biophysical journal 1997;72(3):1335-46.
1996: Steven M Block
Do's and don't's of poster presentation.
Biophysical journal 1996;71(6):3527-9.
1996: Steven M Block
Fifty ways to love your lever: myosin motors.
Cell 1996;87(2):151-7.
1995: H Yin; M D Wang; K Svoboda; Robert Landick; Steven M Block; Jeff Gelles
Transcription against an applied force.
Science (New York, N.Y.) 1995;270(5242):1653-7.
1995: K Svoboda; Partha P Mitra; Steven M Block
Fluctuation analysis of kinesin movement.
Biophysical journal 1995;68(4 Suppl):69S.
1995: Steven M Block; K Svoboda
Analysis of high resolution recordings of motor movement.
Biophysical journal 1995;68(4 Suppl):230S-239S; discussion 239S-241S.
1995: Mark J Schnitzer; Steven M Block
Statistical kinetics of processive enzymes.
Cold Spring Harbor symposia on quantitative biology 1995;60():793-802.
1994: K Svoboda; Partha P Mitra; Steven M Block
Fluctuation analysis of motor protein movement and single enzyme kinetics.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):11782-6.
1994: K Svoboda; Steven M Block
Force and velocity measured for single kinesin molecules.
Cell 1994;77(5):773-84.
1994: K A Fahrner; Steven M Block; S Krishnaswamy; J S Parkinson; Howard C Berg
A mutant hook-associated protein (HAP3) facilitates torsionally induced transformations of the flagellar filament of Escherichia coli.
Journal of molecular biology 1994;238(2):173-86.
1994: K Svoboda; Steven M Block
Biological applications of optical forces.
Annual review of biophysics and biomolecular structure 1994;23():247-85.
1993: K Svoboda; C F Schmidt; Bruce J Schnapp; Steven M Block
Direct observation of kinesin stepping by optical trapping interferometry.
Nature 1993;365(6448):721-7.
1992: Steven M Block
Making light work with optical tweezers.
Nature 1992;360(6403):493-5.
1992: K Svoboda; C F Schmidt; D Branton; Steven M Block
Conformation and elasticity of the isolated red blood cell membrane skeleton.
Biophysical journal 1992;63(3):784-93.
1991: Steven M Block; K A Fahrner; Howard C Berg
Visualization of bacterial flagella by video-enhanced light microscopy.
Journal of bacteriology 1991;173(2):933-6.
1991: Steven M Block; D F Blair; Howard C Berg
Compliance of bacterial polyhooks measured with optical tweezers.
Cytometry 1991;12(6):492-6.
1990: Steven M Block; L S Goldstein; Bruce J Schnapp
Bead movement by single kinesin molecules studied with optical tweezers.
Nature 1990;348(6299):348-52.
1989: Steven M Block; D F Blair; Howard C Berg
Compliance of bacterial flagella measured with optical tweezers.
Nature 1989;338(6215):514-8.