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Timothy Block

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Yanming Du; Tina Gill; Fang Guo; Ju-Tao Guo; Lijuan Wang; Timothy M Block; Jinhong Chang; Andrea Cuconati; Hong Ye; Xiaodong Xu
N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections.
Jason Lamontagne; Richeng Mao; Courtney Mills; Timothy M Block; Dawei Cai; Andrea Cuconati; Cally Goddard; Haitao Guo; Xuanyong Lu
Screening and identification of compounds with antiviral activity against hepatitis B virus using a safe compound library and novel real-time immune-absorbance PCR-based high throughput system.
Timothy M Block; Andrea Cuconati; Robert Gish; Haitao Guo; Anand Mehta; W Thomas London; Ju-Tao Guo
Chronic hepatitis B: What should be the goal for new therapies?

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2013: Yanming Du; Tina Gill; Fang Guo; Ju-Tao Guo; Lijuan Wang; Timothy M Block; Jinhong Chang; Andrea Cuconati; Hong Ye; Xiaodong Xu
N-Alkyldeoxynojirimycin derivatives with novel terminal tertiary amide substitution for treatment of bovine viral diarrhea virus (BVDV), Dengue, and Tacaribe virus infections.
Bioorganic & medicinal chemistry letters 2013;23(7):2172-6.
2013: Jason Lamontagne; Richeng Mao; Courtney Mills; Timothy M Block; Dawei Cai; Andrea Cuconati; Cally Goddard; Haitao Guo; Xuanyong Lu
Screening and identification of compounds with antiviral activity against hepatitis B virus using a safe compound library and novel real-time immune-absorbance PCR-based high throughput system.
Antiviral research 2013;98(1):19-26.
2013: Timothy M Block; Andrea Cuconati; Robert Gish; Haitao Guo; Anand Mehta; W Thomas London; Ju-Tao Guo
Chronic hepatitis B: What should be the goal for new therapies?
Antiviral research 2013;98(1):27-34.
2013: Andrea Cuconati; Cally Goddard; Haitao Guo; Courtney Mills; Xiaodong Xu; Wenquan Yu; Xianchao Zhang; Timothy M Block
Suppression of AKT anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cells.
PloS one 2013;8(1):e54595.
2012: Jinhong Chang; Timothy M Block; Ju-Tao Guo
The innate immune response to hepatitis B virus infection: implications for pathogenesis and therapy.
Antiviral research 2012;96(3):405-13.
2012: Dawei Cai; Andrea Cuconati; Carol E Aldrich; Timothy M Block; Ju-Tao Guo; William S Mason; Courtney Mills; Jeffry Saputelli; Xiaodong Xu; Ran Yan; Wenquan Yu; Haitao Guo
Identification of disubstituted sulfonamide compounds as specific inhibitors of hepatitis B virus covalently closed circular DNA formation.
Antimicrobial agents and chemotherapy 2012;56(8):4277-88.
2012: Wenquan Yu; Kang Zhao; Timothy M Block; Andrea Cuconati; Yanming Du; Tina Gill; Ju-Tao Guo; Xiaowang Qu; Lijuan Wang; Xiaodong Xu; Hong Ye; Jinhong Chang
Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection.
Journal of medicinal chemistry 2012;55(13):6061-75.
2012: Scott Millhouse; Xiaohe Wang; Lisa Faber; Nigel W Fraser; Timothy M Block
Direct evidence that HSV DNA damaged by ultraviolet (UV) irradiation can be repaired in a cell type-dependent manner.
Journal of neurovirology 2012;18(3):231-43.
2012: Hui Nie; Timothy M Block; Alison A Evans; W Thomas London; Xiangdong David Ren
Quantitative dynamics of hepatitis B basal core promoter and precore mutants before and after HBeAg seroconversion.
Journal of hepatology 2012;56(4):795-802.
2012: Benjamin P Song; Wei Song; Timothy M Block; Dean E Brenner; Quan Chen; Surbhi Jain; Selena Y Lin; Ying-Hsiu Su
Detection of hypermethylated vimentin in urine of patients with colorectal cancer.
The Journal of molecular diagnostics : JMD 2012;14(2):112-9.
2012: Hongyan Liang; Ronald Long; Jorge A Marrero; Anand S Mehta; Bradley Nefsky; Timothy M Block; Robert Gish; Julie Hafner; Mengjun Wang; Pamela A Norton
Interleukin-6 and oncostatin M are elevated in liver disease in conjunction with candidate hepatocellular carcinoma biomarker GP73.
Cancer biomarkers : section A of Disease markers 2012;11(4):161-71.
2012: Fang Guo; Ju-Tao Guo; Kui Li; Jennifer Mead; Lijuan Wang; Lai Wei; Nishat Aliya; Timothy M Block; Andrea Cuconati; Jinhong Chang
RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response.
PloS one 2012;7(10):e42583.
2012: Haitao Guo; Chunxiao Xu; Tianlun Zhou; Timothy M Block; Ju-Tao Guo
Characterization of the host factors required for hepadnavirus covalently closed circular (ccc) DNA formation.
PloS one 2012;7(8):e43270.
2012: Surbhi Jain; Selena Y Lin; Yih-Jyh Lin; Meltzer Stephen J.; Wei Song; Timothy M Block; Batbold Boldbaatar; Kung-Chao Chang; Ting-Tsung Chang; Sitong Chen; Shun-Hua Chen; James P Hamilton; Chi-Tan Hu; Ying-Hsiu Su
Impact of the location of CpG methylation within the GSTP1 gene on its specificity as a DNA marker for hepatocellular carcinoma.
PloS one 2012;7(4):e35789.
2011: Jinhong Chang; Ju-Tao Guo; Wouter Schul; Xiaodong Xu; Andy Yip; Timothy M Block
Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection.
Antiviral research 2011;92(2):369-71.
2011: Selena Y Lin; Yih-Jyh Lin; Wei Song; Timothy M Block; Kung-Chao Chang; Ting-Tsung Chang; Shun-Hua Chen; Veerpal Dhillon; Chi-Tan Hu; Surbhi Jain; Lixin Yu; Ying-Hsiu Su
A locked nucleic acid clamp-mediated PCR assay for detection of a p53 codon 249 hotspot mutation in urine.
The Journal of molecular diagnostics : JMD 2011;13(5):474-84.
2011: Wenquan Yu; Kang Zhao; Timothy M Block; Elizabeth Clearfield; Andrea Cuconati; Cally Goddard; Haitao Guo; Courtney Mills; John D Morrey; Neil E Motter; Tong Xiao; Xiaodong Xu
Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.
Journal of medicinal chemistry 2011;54(16):5660-70.
2011: Mary Ann Comunale; Adrian M Di Bisceglie; Robert Gish; Julie Hafner; Andrew Klein; Anne Lamontagne; Jorge A Marrero; Lucy Rodemich-Betesh; Mengjun Wang; Timothy M Block; Anand Mehta
Novel changes in glycosylation of serum Apo-J in patients with hepatocellular carcinoma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011;20(6):1222-9.
2011: C Cohen; S D Holmberg; B J McMahon; J M Block; C L Brosgart; R G Gish; W Thomas London; Timothy M Block
Is chronic hepatitis B being undertreated in the United States?
Journal of viral hepatitis 2011;18(6):377-83.
2011: Xiaowang Qu; Xiaoben Pan; Jessica Weidner; Wenquan Yu; Dominic Alonzi; Xiaodong Xu; Terry D Butters; Timothy M Block; Ju-Tao Guo; Jinhong Chang
Inhibitors of endoplasmic reticulum alpha-glucosidases potently suppress hepatitis C virus virion assembly and release.
Antimicrobial agents and chemotherapy 2011;55(3):1036-44.
2011: Haitao Guo; Xiaoben Pan; Richeng Mao; Xianchao Zhang; Lijuan Wang; Xuanyong Lu; Jinhong Chang; Ju-Tao Guo; Shendra Passic; Fred C Krebs; Brian Wigdahl; Travis K Warren; Cary J Retterer; Sina Bavari; Xiaodong Xu; Andrea Cuconati; Timothy M Block
Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenaviruses.
Antimicrobial agents and chemotherapy 2011;55(2):478-86.
2011: Surbhi Jain; Pin-Wen Lin; Selena Y Lin; Yih-Jyh Lin; Meltzer Stephen J.; Florin Selaru; Wei Song; Timothy M Block; Ting-Tsung Chang; Shun-Hua Chen; Alison A Evans; James P Hamilton; Chi-Tan Hu; Ying-Hsiu Su
Methylation of the CpG sites only on the sense strand of the APC gene is specific for hepatocellular carcinoma.
PloS one 2011;6(11):e26799.
2011: Yuanjie Liu; Ramila Philip; James S Testa; Timothy M Block; Anand S Mehta
A ubiquitin independent degradation pathway utilized by a hepatitis B virus envelope protein to limit antigen presentation.
PloS one 2011;6(9):e24477.
2011: Jinhong Chang; Wouter Schul; Terry D Butters; Andy Yip; Boping Liu; Anne Goh; Suresh B Lakshminarayana; Dominic Alonzi; Gabriele Reinkensmeier; Xiaoben Pan; Xiaowang Qu; Jessica M Weidner; Lijuan Wang; Wenquan Yu; Nigel Borune; Mark A Kinch; Jamie E Rayahin; Robert Moriarty; Xiaodong Xu; Pei-Yong Shi; Ju-Tao Guo; Timothy M Block
Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo.
Antiviral research 2011;89(1):26-34.
2010: Jessica M Weidner; Dong Jiang; Xiao-ben Pan; Jinhong Chang; Timothy M Block; Ju-Tao Guo
Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms.
Journal of virology 2010;84(24):12646-57.
2010: Scott Millhouse; Ying-Hsiu Su; Xianchao Zhang; Xiaohe Wang; Benjamin P Song; Li Zhu; Emily Oppenheim; Nigel W Fraser; Timothy M Block
Evidence that herpes simplex virus DNA derived from quiescently infected cells in vitro, and latently infected cells in vivo, is physically damaged.
Journal of neurovirology 2010;16(5):384-98.
2010: Pamela A Norton; Stephan Menne; Gomathinayagam Sinnathamby; Lucy Betesh; Paul J Cote; Ramila Philip; Anand S Mehta; Bud C Tennant; Timothy M Block
Glucosidase inhibition enhances presentation of de-N-glycosylated hepatitis B virus epitopes by major histocompatibility complex class I in vitro and in woodchucks.
Hepatology (Baltimore, Md.) 2010;52(4):1242-50.
2010: Chunxiao Xu; Haitao Guo; Xiao-ben Pan; Richeng Mao; Wenquan Yu; Xiaodong Xu; Lai Wei; Jinhong Chang; Timothy M Block; Ju-Tao Guo
Interferons accelerate decay of replication-competent nucleocapsids of hepatitis B virus.
Journal of virology 2010;84(18):9332-40.
2010: Dong Jiang; Jessica M Weidner; Min Qing; Xiao-ben Pan; Haitao Guo; Chunxiao Xu; Xianchao Zhang; Alex Birk; Jinhong Chang; Pei-Yong Shi; Timothy M Block; Ju-Tao Guo
Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections.
Journal of virology 2010;84(16):8332-41.
2010: Hie-Won L Hann; Su Hee Kim; Ronald E Long; Meejin Ahn; Timothy M Block; Mary Ann Comunale; Julie Hafner; Susan Park; Mengjun Wang; Anand Mehta
Analysis of GP73 in patients with HCC as a function of anti-cancer treatment.
Cancer biomarkers : section A of Disease markers 2010;7(6):269-73.
2010: Haitao Guo; Richeng Mao; Timothy M Block; Ju-Tao Guo
Production and function of the cytoplasmic deproteinized relaxed circular DNA of hepadnaviruses.
Journal of virology 2010;84(1):387-96.
2010: Jason Lamontagne; Mark Pinkerton; Timothy M Block; Xuanyong Lu
Hepatitis B and hepatitis C virus replication upregulates serine protease inhibitor Kazal, resulting in cellular resistance to serine protease-dependent apoptosis.
Journal of virology 2010;84(2):907-17.
2009: Dongling Ma; Dong Jiang; Min Qing; Jessica M Weidner; Xiaowang Qu; Haitao Guo; Jinhong Chang; Baohua Gu; Pei-Yong Shi; Timothy M Block; Ju-Tao Guo
Antiviral effect of interferon lambda against West Nile virus.
Antiviral research 2009;83(1):53-60.
2009: Mengjun Wang; Ronald E Long; Mary Ann Comunale; Omer Junaidi; Jorge A Marrero; Adrian M Di Bisceglie; Timothy M Block; Anand S Mehta
Novel fucosylated biomarkers for the early detection of hepatocellular carcinoma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009;18(6):1914-21.
2009: Xiangdong David Ren; Selena Y Lin; Xiaohe Wang; Tianlun Zhou; Timothy M Block; Ying-Hsiu Su
Rapid and sensitive detection of hepatitis B virus 1762T/1764A double mutation from hepatocellular carcinomas using LNA-mediated PCR clamping and hybridization probes.
Journal of virological methods 2009;158(1-2):24-9.
2009: Jinhong Chang; Lijuan Wang; Dongling Ma; Xiaowang Qu; Haitao Guo; Xiaodong Xu; Peter M Mason; Nigel Bourne; Robert Moriarty; Baohua Gu; Ju-Tao Guo; Timothy M Block
Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses.
Antimicrobial agents and chemotherapy 2009;53(4):1501-8.
2009: Ender Simsek; Gomathinayagam Sinnathamby; Timothy M Block; Yuanjie Liu; Ramila Philip; Anand S Mehta; Pamela A Norton
Inhibition of cellular alpha-glucosidases results in increased presentation of hepatitis B virus glycoprotein-derived peptides by MHC class I.
Virology 2009;384(1):12-5.
2009: Mary Ann Comunale; Mengjun Wang; Julie Hafner; Jonathan Krakover; Lucy Rodemich; Brent Kopenhaver; Ronald E Long; Omer Junaidi; Adrian M Di Bisceglie; Timothy M Block; Anand S Mehta
Identification and development of fucosylated glycoproteins as biomarkers of primary hepatocellular carcinoma.
Journal of proteome research 2009;8(2):595-602.
2009: Haitao Guo; Dong Jiang; Dongling Ma; Jinhong Chang; Anne Marie Dougherty; Andrea Cuconati; Timothy M Block; Ju-Tao Guo
Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells.
Journal of virology 2009;83(2):847-58.
2008: Ying-Hsiu Su; Mengjun Wang; Dean E Brenner; Pamela A Norton; Timothy M Block
Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps.
Annals of the New York Academy of Sciences 2008;1137():197-206.
2008: Ying-Hsiu Su; Janet Song; Zhili Wang; Xiao-He Wang; Mengjun Wang; Dean E Brenner; Timothy M Block
Removal of high-molecular-weight DNA by carboxylated magnetic beads enhances the detection of mutated K-ras DNA in urine.
Annals of the New York Academy of Sciences 2008;1137():82-91.
2008: Jinhong Chang; Ju-Tao Guo; Dong Jiang; Haitao Guo; John M Taylor; Timothy M Block
Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells.
Journal of virology 2008;82(16):8215-23.
2008: Pamela A Norton; Mary Ann Comunale; Jonathan Krakover; Lucy Rodemich; Natalie Pirog; Anthony D'Amelio; Ramila Philip; Anand S Mehta; Timothy M Block
N-linked glycosylation of the liver cancer biomarker GP73.
Journal of cellular biochemistry 2008;104(1):136-49.
2008: Xuanyong Lu; Jason Lamontagne; Felix Lu; Timothy M Block
Tumor-associated protein SPIK/TATI suppresses serine protease dependent cell apoptosis.
Apoptosis : an international journal on programmed cell death 2008;13(4):483-94.
2008: Dong Jiang; Haitao Guo; Chunxiao Xu; Jinhong Chang; Baohua Gu; Lijuan Wang; Timothy M Block; Ju-Tao Guo
Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus.
Journal of virology 2008;82(4):1665-78.
2008: Anand S Mehta; Ronald E Long; Mary Ann Comunale; Mengjun Wang; Lucy Rodemich; Jonathan Krakover; Ramila Philip; Jorge A Marrero; Raymond A Dwek; Timothy M Block
Increased levels of galactose-deficient anti-Gal immunoglobulin G in the sera of hepatitis C virus-infected individuals with fibrosis and cirrhosis.
Journal of virology 2008;82(3):1259-70.
2008: Timothy M Block; Jorge A Marrero; Robert G Gish; Morris Sherman; W Thomas London; sudhir srivastava; Paul D Wagner
The degree of readiness of selected biomarkers for the early detection of hepatocellular carcinoma: notes from a recent workshop.
Cancer biomarkers : section A of Disease markers 2008;4(1):19-33.
2008: Hie-Won L Hann; S-H Han; Timothy M Block; M Harris; J-F Maa; R T Fisher; E Atillasoy
Symptomatology and health attitudes of chronic hepatitis B patients in the USA.
Journal of viral hepatitis 2008;15(1):42-51.
2008: C Cohen; Alison A Evans; W T London; J Block; M Conti; Timothy M Block
Underestimation of chronic hepatitis B virus infection in the United States of America.
Journal of viral hepatitis 2008;15(1):12-3.
2007: Yuanjie Liu; Tianlun Zhou; Ender Simsek; Timothy M Block; Anand Mehta
The degradation pathway for the HBV envelope proteins involves proteolysis prior to degradation via the cytosolic proteasome.
Virology 2007;369(1):69-77.
2007: Ju-Tao Guo; Tianlun Zhou; Haitao Guo; Timothy M Block
Alpha interferon-induced antiviral response noncytolytically reduces replication defective adenovirus DNA in MDBK cells.
Antiviral research 2007;76(3):232-40.
2007: Anne Marie Dougherty; Haitao Guo; Gael Westby; Yuanjie Liu; Ender Simsek; Ju-Tao Guo; Anand Mehta; Pamela Norton; Baohua Gu; Timothy M Block; Andrea Cuconati
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion.
Antimicrobial agents and chemotherapy 2007;51(12):4427-37.
2007: Timothy M Block; Haitao Guo; Ju-Tao Guo
Molecular virology of hepatitis B virus for clinicians.
Clinics in liver disease 2007;11(4):685-706, vii.
2007: Haitao Guo; Dong Jiang; Tianlun Zhou; Andrea Cuconati; Timothy M Block; Ju-Tao Guo
Characterization of the intracellular deproteinized relaxed circular DNA of hepatitis B virus: an intermediate of covalently closed circular DNA formation.
Journal of virology 2007;81(22):12472-84.
2007: Haitao Guo; Tianlun Zhou; Dong Jiang; Andrea Cuconati; Guang-Hui Xiao; Timothy M Block; Ju-Tao Guo
Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway.
Journal of virology 2007;81(18):10072-80.
2007: Yuanjie Liu; Ender Simsek; Pamela Norton; Gomathinayagam Sinnathamby; Ramila Philip; Timothy M Block; Tianlun Zhou; Anand Mehta
The role of the downstream signal sequences in the maturation of the HBV middle surface glycoprotein: development of a novel therapeutic vaccine candidate.
Virology 2007;365(1):10-9.
2007: Benjamas Aiamkitsumrit; Xianchao Zhang; Timothy M Block; Pamela Norton; Nigel W Fraser; Ying-Hsiu Su
Herpes simplex virus type 1 ICP4 deletion mutant virus d120 infection failed to induce apoptosis in nerve growth factor-differentiated PC12 cells.
Journal of neurovirology 2007;13(4):305-14.
2007: Baohua Gu; Peter Mason; Lijuan Wang; Pamela Norton; Nigel Bourne; Robert Moriarty; Anand Mehta; Mehendra Despande; Rajendra Shah; Timothy M Block
Antiviral profiles of novel iminocyclitol compounds against bovine viral diarrhea virus, West Nile virus, dengue virus and hepatitis B virus.
Antiviral chemistry & chemotherapy 2007;18(1):49-59.
2006: Ying-Hsiu Su; Xianchao Zhang; Xiaohe Wang; Nigel W Fraser; Timothy M Block
Evidence that the immediate-early gene product ICP4 is necessary for the genome of the herpes simplex virus type 1 ICP4 deletion mutant strain d120 to circularize in infected cells.
Journal of virology 2006;80(23):11589-97.
2006: Tianlun Zhou; Haitao Guo; Ju-Tao Guo; Andrea Cuconati; Anand Mehta; Timothy M Block
Hepatitis B virus e antigen production is dependent upon covalently closed circular (ccc) DNA in HepAD38 cell cultures and may serve as a cccDNA surrogate in antiviral screening assays.
Antiviral research 2006;72(2):116-24.
2006: Ying-Hsiu Su; Xianchao Zhang; Benjamas Aiamkitsumrit; Qiyi Tang; Gerd Maul; Nigel W Fraser; Timothy M Block
The stability of herpes simplex virus type I genomes in infected Vero cells undergoing viral induced apoptosis.
Journal of neurovirology 2006;12(5):375-86.
2006: Richard R Drake; E Ellen Schwegler; Gunjan Malik; Jose Diaz; Timothy M Block; Anand Mehta; O John Semmes
Lectin capture strategies combined with mass spectrometry for the discovery of serum glycoprotein biomarkers.
Molecular & cellular proteomics : MCP 2006;5(10):1957-67.
2006: Baohua Gu; Serguey Ouzunov; Liguan Wang; Peter Mason; Nigel Bourne; Andrea Cuconati; Timothy M Block
Discovery of small molecule inhibitors of West Nile virus using a high-throughput sub-genomic replicon screen.
Antiviral research 2006;70(2):39-50.
2006: Timothy M Block; Anand S Mehta; Baruch S Blumberg; Raymond A Dwek
Does rapid oligomerization of hepatitis B envelope proteins play a role in resistance to proteasome degradation and enhance chronicity?
DNA and cell biology 2006;25(3):165-70.
2006: Mary Ann Comunale; Melissa Lowman; Ronald E Long; Jonathan Krakover; Ramila Philip; Steven H Seeholzer; Alison A Evans; Hie-Won L Hann; Timothy M Block; Anand S Mehta
Proteomic analysis of serum associated fucosylated glycoproteins in the development of primary hepatocellular carcinoma.
Journal of proteome research 2006;5(2):308-15.
2006: Ender Simsek; Xuanyong Lu; Serguey Ouzounov; Timothy M Block; Anand S Mehta
alpha-Glucosidase inhibitors have a prolonged antiviral effect against hepatitis B virus through the sustained inhibition of the large and middle envelope glycoproteins.
Antiviral chemistry & chemotherapy 2006;17(5):259-67.
2005: Jorge A Marrero; Patrick R Romano; Olga Nikolaeva; Laura F Steel; Anand Mehta; Claus J Fimmel; Mary Ann Comunale; Anthony D'Amelio; Anna S F Lok; Timothy M Block
GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma.
Journal of hepatology 2005;43(6):1007-12.
2005: Ender Simsek; Anand Mehta; Tianlun Zhou; Raymond A Dwek; Timothy M Block
Hepatitis B virus large and middle glycoproteins are degraded by a proteasome pathway in glucosidase-inhibited cells but not in cells with functional glucosidase enzyme.
Journal of virology 2005;79(20):12914-20.
2005: E Ellen Schwegler; Lisa H Cazares; Laura F Steel; Bao-Ling Adam; David A Johnson; O John Semmes; Timothy M Block; Jorge A Marrero; Richard R Drake
SELDI-TOF MS profiling of serum for detection of the progression of chronic hepatitis C to hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2005;41(3):634-42.
2005: Pamela A Norton; Bertha Conyers; Qiaoke Gong; Laura F Steel; Timothy M Block; Anand S Mehta
Assays for glucosidase inhibitors with potential antiviral activities: secreted alkaline phosphatase as a surrogate marker.
Journal of virological methods 2005;124(1-2):167-72.
2005: Timothy M Chapman; Ieuan G Davies; Baohua Gu; Timothy M Block; David I C Scopes; Philip A Hay; Steve Courtney; Luke A McNeill; Christopher J Schofield; Benjamin G Davis
Glyco- and peptidomimetics from three-component Joullié-Ugi coupling show selective antiviral activity.
Journal of the American Chemical Society 2005;127(2):506-7.
2005: Timothy M Block; Mary Ann Comunale; Melissa Lowman; Laura F Steel; Patrick R Romano; Claus J Fimmel; Bud C Tennant; W Thomas London; Alison A Evans; Baruch S Blumberg; Raymond A Dwek; Taj S Mattu; Anand S Mehta
Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):779-84.
2005: Ying-Hsiu Su; Mengjun Wang; Benjamas Aiamkitsumrit; Dean E Brenner; Timothy M Block
Detection of a K-ras mutation in urine of patients with colorectal cancer.
Cancer biomarkers : section A of Disease markers 2005;1(2-3):177-82.
2004: Alan K Ng; Timothy M Block; Benjamas Aiamkitsumrit; Mengjun Wang; Emily Clementi; Ting-Ting Wu; John M Taylor; Ying-Hsiu Su
Construction of a herpes simplex virus type 1 mutant with only a three-nucleotide change in the branchpoint region of the latency-associated transcript (LAT) and the stability of its two-kilobase LAT intron.
Journal of virology 2004;78(22):12097-106.
2004: Timothy M Block; W Thomas London
Surrogate markers of efficacy for medical treatment of viral hepatitis.
Biotechnology healthcare 2004;1(5):42-8.
2004: Xuanyong Lu; Paul Weiss; Timothy M Block
A phage with high affinity for hepatitis B surface antigen for the detection of HBsAg.
Journal of virological methods 2004;119(1):51-4.
2004: Ying-Hsiu Su; Mengjun Wang; Timothy M Block; Olfert Landt; Irina Botezatu; Ol'ga Serdyuk; Anatoly Lichtenstein; Hovsep Melkonyan; L David Tomei; Samuil R Umansky
Transrenal DNA as a diagnostic tool: important technical notes.
Annals of the New York Academy of Sciences 2004;1022():81-9.
2004: Anand S Mehta; Baohua Gu; Bertha Conyers; Serguey Ouzounov; Lijuan Wang; Robert M Moriarty; Raymond A Dwek; Timothy M Block
alpha-Galactosylceramide and novel synthetic glycolipids directly induce the innate host defense pathway and have direct activity against hepatitis B and C viruses.
Antimicrobial agents and chemotherapy 2004;48(6):2085-90.
2004: Ying-Hsiu Su; Mengjun Wang; Dean E Brenner; Alan Ng; Hovsep Melkonyan; Samuil R Umansky; Sapna Syngal; Timothy M Block
Human urine contains small, 150 to 250 nucleotide-sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer.
The Journal of molecular diagnostics : JMD 2004;6(2):101-7.
2004: Mary Ann Comunale; Taj S Mattu; Melissa A Lowman; Alison A Evans; W Thomas London; O John Semmes; Michael Ward; Richard Drake; Patrick R Romano; Laura F Steel; Timothy M Block; Anand Mehta
Comparative proteomic analysis of de-N-glycosylated serum from hepatitis B carriers reveals polypeptides that correlate with disease status.
Proteomics 2004;4(3):826-38.
2004: Xuanyong Lu; Timothy M Block
Enhancement of infection of HepG2 cells in culture by predigestion of hepadnavirus with V8 protease.
Methods in molecular medicine 2004;96():199-208.
2004: Mengjun Wang; Timothy M Block; Laura F Steel; Dean E Brenner; Ying-Hsiu Su
Preferential isolation of fragmented DNA enhances the detection of circulating mutated k-ras DNA.
Clinical chemistry 2004;50(1):211-3.
2003: Xuanyong Lu; Trang Tran; Ender Simsek; Timothy M Block
The alkylated imino sugar, n-(n-Nonyl)-deoxygalactonojirimycin, reduces the amount of hepatitis B virus nucleocapsid in tissue culture.
Journal of virology 2003;77(22):11933-40.
2003: Timothy M Block; Anand S Mehta; Claus J Fimmel; Robert Jordan
Molecular viral oncology of hepatocellular carcinoma.
Oncogene 2003;22(33):5093-107.
2003: Laura F Steel; Donna Shumpert; Michael Trotter; Steven H Seeholzer; Alison A Evans; W Thomas London; Raymond A Dwek; Timothy M Block
A strategy for the comparative analysis of serum proteomes for the discovery of biomarkers for hepatocellular carcinoma.
Proteomics 2003;3(5):601-9.
2003: Pamela A Norton; Qiaoke Gong; Anand S Mehta; Xuanyong Lu; Timothy M Block
Hepatitis B virus-mediated changes of apolipoprotein mRNA abundance in cultured hepatoma cells.
Journal of virology 2003;77(9):5503-6.
2003: Laura F Steel; Michael G Trotter; Pamela B Nakajima; Taj S Mattu; Gregory Gonye; Timothy M Block
Efficient and specific removal of albumin from human serum samples.
Molecular & cellular proteomics : MCP 2003;2(4):262-70.
2002: Anand Mehta; Bertha Conyers; D Lorne J Tyrrell; Kathie-Anne Walters; Graham A Tipples; Raymond A Dwek; Timothy M Block
Structure-activity relationship of a new class of anti-hepatitis B virus agents.
Antimicrobial agents and chemotherapy 2002;46(12):4004-8.
2002: Robert Jordan; Lijuan Wang; Thomas M Graczyk; Timothy M Block; Patrick R Romano
Replication of a cytopathic strain of bovine viral diarrhea virus activates PERK and induces endoplasmic reticulum stress-mediated apoptosis of MDBK cells.
Journal of virology 2002;76(19):9588-99.
2002: Anand Mehta; Serguey Ouzounov; Robert Jordan; Ender Simsek; Xuanyong Lu; Robert M Moriarty; Gary Jacob; Raymond A Dwek; Timothy M Block
Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ.
Antiviral chemistry & chemotherapy 2002;13(5):299-304.
2002: Serguey Ouzounov; Anand Mehta; Raymond A Dwek; Timothy M Block; Robert Jordan
The combination of interferon alpha-2b and n-butyl deoxynojirimycin has a greater than additive antiviral effect upon production of infectious bovine viral diarrhea virus (BVDV) in vitro: implications for hepatitis C virus (HCV) therapy.
Antiviral research 2002;55(3):425-35.
2002: Robert Jordan; Olga V Nikolaeva; Lijuan Wang; Bertha Conyers; Anand Mehta; Raymond A Dwek; Timothy M Block
Inhibition of host ER glucosidase activity prevents Golgi processing of virion-associated bovine viral diarrhea virus E2 glycoproteins and reduces infectivity of secreted virions.
Virology 2002;295(1):10-9.
2001: Timothy M Block; Robert Jordan
Iminosugars as possible broad spectrum anti hepatitis virus agents: the glucovirs and alkovirs.
Antiviral chemistry & chemotherapy 2001;12(6):317-25.
2001: X Lu; Y Lu; R Geschwindt; Raymond A Dwek; Timothy M Block
Hepatitis B virus MHBs antigen is selectively sensitive to glucosidase-mediated processing in the endoplasmic reticulum.
DNA and cell biology 2001;20(10):647-56.
2001: Anand Mehta; S Carrouée; Bertha Conyers; Robert Jordan; Terry D Butters; Raymond A Dwek; Timothy M Block
Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: therapeutic implications.
Hepatology (Baltimore, Md.) 2001;33(6):1488-95.
2001: A Mehta; X Lu; Timothy M Block; A Willis; Raymond A Dwek; B Tennant; Baruch S Blumberg
Synovial stimulatory protein fragments copurify with woodchuck hepatitis virus: implications for the etiology of arthritis in chronic hepatitis B virus infection.
Arthritis and rheumatism 2001;44(2):486-7.
2001: Laura F Steel; Taj S Mattu; Anand Mehta; Holger F Hebestreit; Raymond A Dwek; Alison A Evans; W Thomas London; Timothy M Block
A proteomic approach for the discovery of early detection markers of hepatocellular carcinoma.
Disease markers 2001;17(3):179-89.
1999: Nicole Zitzmann; Anand S Mehta; S Carrouée; Terry D Butters; Frances M Platt; J McCauley; Baruch S Blumberg; Raymond A Dwek; Timothy M Block
Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11878-82.
1999: Ying-Hsiu Su; R L Meegalla; R Chowhan; CL Cubitt; John E Oakes; Robert N Lausch; Nigel W Fraser; Timothy M Block
Human corneal cells and other fibroblasts can stimulate the appearance of herpes simplex virus from quiescently infected PC12 cells.
Journal of virology 1999;73(5):4171-80.
1998: A Mehta; Nicole Zitzmann; Pauline M Rudd; Timothy M Block; Raymond A Dwek
Alpha-glucosidase inhibitors as potential broad based anti-viral agents.
FEBS letters 1998;430(1-2):17-22.
1998: Timothy M Block; Xuanyong Lu; Anand S Mehta; Baruch S Blumberg; Bud C Tennant; M Ebling; Brent E Korba; D M Lansky; G S Jacob; Raymond A Dwek
Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking.
Nature medicine 1998;4(5):610-4.
1998: Timothy M Block; X Lu; A Mehta; J Park; Baruch S Blumberg; Raymond A Dwek
Role of glycan processing in hepatitis B virus envelope protein trafficking.
Advances in experimental medicine and biology 1998;435():207-16.
1998: A Mehta; Timothy M Block; Raymond A Dwek
The role of N-linked glycosylation in the secretion of hepatitis B virus.
Advances in experimental medicine and biology 1998;435():195-205.
1997: A Mehta; Pauline M Rudd; Timothy M Block; Raymond A Dwek
A strategy for anti-viral intervention: the use of alpha-glucosidase inhibitors to prevent chaperone-mediated folding of viral envelope glycoproteins.
Biochemical Society transactions 1997;25(4):1188-93.
1997: X Lu; A Mehta; M Dadmarz; Raymond A Dwek; Baruch S Blumberg; Timothy M Block
Aberrant trafficking of hepatitis B virus glycoproteins in cells in which N-glycan processing is inhibited.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2380-5.
1997: A Mehta; X Lu; Timothy M Block; Baruch S Blumberg; Raymond A Dwek
Hepatitis B virus (HBV) envelope glycoproteins vary drastically in their sensitivity to glycan processing: evidence that alteration of a single N-linked glycosylation site can regulate HBV secretion.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1822-7.
1996: J Maggioncalda; A Mehta; Y H Su; Nigel W Fraser; Timothy M Block
Correlation between herpes simplex virus type 1 rate of reactivation from latent infection and the number of infected neurons in trigeminal ganglia.
Virology 1996;225(1):72-81.
1996: James M Hill; J B Maggioncalda; HH Garza; Y H Su; Nigel W Fraser; Timothy M Block
In vivo epinephrine reactivation of ocular herpes simplex virus type 1 in the rabbit is correlated to a 370-base-pair region located between the promoter and the 5' end of the 2.0 kilobase latency-associated transcript.
Journal of virology 1996;70(10):7270-4.
1996: T T Wu; Y H Su; Timothy M Block; John M Taylor
Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear.
Journal of virology 1996;70(9):5962-7.
1996: J Maggioncalda; A Mehta; Omar Bagasra; Nigel W Fraser; Timothy M Block
A herpes simplex virus type 1 mutant with a deletion immediately upstream of the LAT locus establishes latency and reactivates from latently infected mice with normal kinetics.
Journal of neurovirology 1996;2(4):268-78.
1995: X Lu; A Mehta; R Dwek; T Butters; Timothy M Block
Evidence that N-linked glycosylation is necessary for hepatitis B virus secretion.
Virology 1995;213(2):660-5.
1995: S L Deshmane; Tibor Valyi-Nagy; Timothy M Block; J Maggioncalda; John H Wolfe; A Dillner; Nigel W Fraser
An HSV-1 containing the rat beta-glucuronidase cDNA inserted within the LAT gene is less efficient than the parental strain at establishing a transcriptionally active state during latency in neurons.
Gene therapy 1995;2(3):209-17.
1995: A Mehta; J Maggioncalda; Omar Bagasra; S Thikkavarapu; P Saikumari; Tibor Valyi-Nagy; Nigel W Fraser; Timothy M Block
In situ DNA PCR and RNA hybridization detection of herpes simplex virus sequences in trigeminal ganglia of latently infected mice.
Virology 1995;206(1):633-40.
1994: J Maggioncalda; A Mehta; Nigel W Fraser; Timothy M Block
Analysis of a herpes simplex virus type 1 LAT mutant with a deletion between the putative promoter and the 5' end of the 2.0-kilobase transcript.
Journal of virology 1994;68(12):7816-24.
1994: Timothy M Block; S Barney; J Masonis; J Maggioncalda; Tibor Valyi-Nagy; Nigel W Fraser
Long term herpes simplex virus type 1 infection of nerve growth factor-treated PC12 cells.
The Journal of general virology 1994;75 ( Pt 9)():2481-7.
1994: Timothy M Block; X Lu; Frances M Platt; G R Foster; W H Gerlich; Baruch S Blumberg; Raymond A Dwek
Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2235-9.
1993: E F Fynan; Donald l Ewert; Timothy M Block
Latency and reactivation of Marek's disease virus in B lymphocytes transformed by avian leukosis virus.
The Journal of general virology 1993;74 ( Pt 10)():2163-70.
1993: Timothy M Block; S Deshmane; J Masonis; J Maggioncalda; Tibor Valyi-Nagy; Nigel W Fraser
An HSV LAT null mutant reactivates slowly from latent infection and makes small plaques on CV-1 monolayers.
Virology 1993;192(2):618-30.
1992: Nigel W Fraser; Timothy M Block; J G Spivack
The latency-associated transcripts of herpes simplex virus: RNA in search of function.
Virology 1992;191(1):1-8.
1992: R H Grafstrom; K Zachariasewycz; R A Brigandi; Timothy M Block
Genetically engineered bacteria to identify and produce anti-viral agents.
Advances in experimental medicine and biology 1992;312():25-40.
1991: Nigel W Fraser; J G Spivack; Z Wroblewska; Timothy M Block; S L Deshmane; Tibor Valyi-Nagy; R Natarajan; R M Gesser
A review of the molecular mechanism of HSV-1 latency.
Current eye research 1991;10 Suppl():1-13.
1990: Timothy M Block; R H Grafstrom
Novel bacteriological assay for detection of potential antiviral agents.
Antimicrobial agents and chemotherapy 1990;34(12):2337-41.
1990: Timothy M Block; J G Spivack; I Steiner; S Deshmane; M T McIntosh; R P Lirette; Nigel W Fraser
A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection.
Journal of virology 1990;64(7):3417-26.
1988: Timothy M Block; R Jordan
Herpes simplex virus type 1 alpha gene containing plasmids can inhibit expression regulated from an alpha promoter in CV-1 but not HeLa cells.
Virus research 1988;11(4):269-79.