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Linus Shen

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Linus L Shen; Candace Black-Schaefer; Yingna Cai; Peter Dandliker; Bruce A Beutel
Mechanism of action of a novel series of naphthyridine-type ribosome inhibitors: enhancement of tRNA footprinting at the decoding site of 16S rRNA.
Peter Dandliker; Steve D Pratt; Angela M Nilius; Candace Black-Schaefer; Xiaoan Ruan; Danli L Towne; Richard F Clark; Erika E Englund; Rolf Wagner; Moshe Weitzberg; Linda E Chovan; Robert Hickman; Melissa M Daly; Stephan J Kakavas; Ping Zhong; Zhensheng Cao; Caroline A David; Xiaoling Xuei; Claude G Lerner; Niru B Soni; Mai-Ha Bui; Linus L Shen; Yingna Cai; Philip J Merta; Anne Y C Saiki; Bruce A Beutel
Novel antibacterial class.
Angela M Nilius; Linus L Shen; Dena M Hensey-Rudloff; Laurel S Almer; Jill M Beyer; Darlene Balli; Yingna Cai; Robert K Flamm
In vitro antibacterial potency and spectrum of ABT-492, a new fluoroquinolone.

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2005: Linus L Shen; Candace Black-Schaefer; Yingna Cai; Peter Dandliker; Bruce A Beutel
Mechanism of action of a novel series of naphthyridine-type ribosome inhibitors: enhancement of tRNA footprinting at the decoding site of 16S rRNA.
Antimicrobial agents and chemotherapy 2005;49(5):1890-7.
2003: Peter Dandliker; Steve D Pratt; Angela M Nilius; Candace Black-Schaefer; Xiaoan Ruan; Danli L Towne; Richard F Clark; Erika E Englund; Rolf Wagner; Moshe Weitzberg; Linda E Chovan; Robert Hickman; Melissa M Daly; Stephan J Kakavas; Ping Zhong; Zhensheng Cao; Caroline A David; Xiaoling Xuei; Claude G Lerner; Niru B Soni; Mai-Ha Bui; Linus L Shen; Yingna Cai; Philip J Merta; Anne Y C Saiki; Bruce A Beutel
Novel antibacterial class.
Antimicrobial agents and chemotherapy 2003;47(12):3831-9.
2003: Angela M Nilius; Linus L Shen; Dena M Hensey-Rudloff; Laurel S Almer; Jill M Beyer; Darlene Balli; Yingna Cai; Robert K Flamm
In vitro antibacterial potency and spectrum of ABT-492, a new fluoroquinolone.
Antimicrobial agents and chemotherapy 2003;47(10):3260-9.
2003: Hanlin Gao; Edith F Yamasaki; Kenneth K Chan; Linus L Shen; Robert M Snapka
DNA sequence specificity for topoisomerase II poisoning by the quinoxaline anticancer drugs XK469 and CQS.
Molecular pharmacology 2003;63(6):1382-8.
2001: KC Huang; Hanlin Gao; Edith F Yamasaki; Dale R Grabowski; S Liu; Linus L Shen; Kenneth K Chan; Ram Ganapathi; Robert M Snapka
Topoisomerase II poisoning by ICRF-193.
The Journal of biological chemistry 2001;276(48):44488-94.
2000: Hanlin Gao; Edith F Yamasaki; Kenneth K Chan; Linus L Shen; Robert M Snapka
Chloroquinoxaline sulfonamide (NSC 339004) is a topoisomerase IIalpha/beta poison.
Cancer research 2000;60(21):5937-40.
2000: Qun Li; Lester A Mitscher; Linus L Shen
The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors.
Medicinal research reviews 2000;20(4):231-93.
1999: Zhenkun Ma; Daniel T Chu; C S Cooper; Qun Li; AK Fung; Sanyi Wang; Linus L Shen; Robert K Flamm; Angela M Nilius; JD Alder; Jonathan A Meulbroek; Yat Sun Or
Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.
Journal of medicinal chemistry 1999;42(20):4202-13.
1999: AK Fung; Linus L Shen
The 2-pyridone antibacterial agents: 8-position modifications.
Current pharmaceutical design 1999;5(7):515-43.
1999: Anne Y C Saiki; Linus L Shen; Chih-Ming Chen; J Baranowski; Claude G Lerner
DNA cleavage activities of Staphylococcus aureus gyrase and topoisomerase IV stimulated by quinolones and 2-pyridones.
Antimicrobial agents and chemotherapy 1999;43(7):1574-7.
1998: Qun Li; Weibo Wang; K B Berst; Akiyo Claiborne; Lisa Hasvold; K Raye; Michael Tufano; Angela M Nilius; Linus L Shen; Robert K Flamm; JD Alder; Kennan Marsh; D Crowell; Daniel T Chu; Jacob J Plattner
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents.
Bioorganic & medicinal chemistry letters 1998;8(15):1953-8.
1998: KE Frank; Pratik Devasthale; Elmer J Gentry; V T Ravikumar; A Keschavarz-Shokri; Lester A Mitscher; Angela M Nilius; Linus L Shen; Ribhi Shawar; W R Baker
A simple, inexpensive apparatus for performance of preparative scale solution phase multiple parallel synthesis of drug analogs. II. Biological evaluation of a retrospective library of quinolone antiinfective agents.
Combinatorial chemistry & high throughput screening 1998;1(2):89-99.
1996: Qun Li; Daniel T Chu; A Claiborne; C S Cooper; C M Lee; K Raye; K B Berst; P Donner; W Wang; L Hasvold; A Fung; Z Ma; Michael Tufano; Robert K Flamm; Linus L Shen; J Baranowski; Angela M Nilius; JD Alder; Jonathan A Meulbroek; Kennan Marsh; D Crowell; Y Hui; L Seif; L M Melcher; Jacob J Plattner
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents.
Journal of medicinal chemistry 1996;39(16):3070-88.
1994: P A Permana; Robert M Snapka; Linus L Shen; Daniel T Chu; J J Clement; Jacob J Plattner
Quinobenoxazines: a class of novel antitumor quinolones and potent mammalian DNA topoisomerase II catalytic inhibitors.
Biochemistry 1994;33(37):11333-9.
1994: Linus L Shen; J M Fostel
DNA topoisomerase inhibitors as antifungal agents.
Advances in pharmacology (San Diego, Calif.) 1994;29B():227-44.
1994: Linus L Shen
Molecular mechanisms of DNA gyrase inhibition by quinolone antibacterials.
Advances in pharmacology (San Diego, Calif.) 1994;29A():285-304.
1992: Linus L Shen; J Baranowski; J Fostel; D A Montgomery; Paul Lartey
DNA topoisomerases from pathogenic fungi: targets for the discovery of antifungal drugs.
Antimicrobial agents and chemotherapy 1992;36(12):2778-84.
1992: J M Fostel; D A Montgomery; Linus L Shen
Characterization of DNA topoisomerase I from Candida albicans as a target for drug discovery.
Antimicrobial agents and chemotherapy 1992;36(10):2131-8.
1991: N S Burres; D A Barber; S P Gunasekera; Linus L Shen; J J Clement
Antitumor activity and biochemical effects of topsentin.
Biochemical pharmacology 1991;42(4):745-51.
1989: Linus L Shen
A reply: "Do quinolones bind to DNA?"--Yes.
Biochemical pharmacology 1989;38(12):2042-4.
1989: Linus L Shen; Lester A Mitscher; P N Sharma; T J O'Donnell; D W Chu; C S Cooper; T Rosen; A G Pernet
Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug--DNA binding model.
Biochemistry 1989;28(9):3886-94.
1989: Linus L Shen; J Baranowski; A G Pernet
Mechanism of inhibition of DNA gyrase by quinolone antibacterials: specificity and cooperativity of drug binding to DNA.
Biochemistry 1989;28(9):3879-85.
1989: Linus L Shen; William Kohlbrenner; Weigl Debra; J Baranowski
Mechanism of quinolone inhibition of DNA gyrase. Appearance of unique norfloxacin binding sites in enzyme-DNA complexes.
The Journal of biological chemistry 1989;264(5):2973-8.
1987: Lester A Mitscher; P N Sharma; Daniel T Chu; Linus L Shen; A G Pernet
Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H- pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin).
Journal of medicinal chemistry 1987;30(12):2283-6.
1986: Lester A Mitscher; P N Sharma; Daniel T Chu; Linus L Shen; A G Pernet
Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid.
Journal of medicinal chemistry 1986;29(10):2044-7.
1985: Linus L Shen; A G Pernet
Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drugs is DNA.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(2):307-11.
1984: Thomas Högberg; I Khanna; S D Drake; Lester A Mitscher; Linus L Shen
Structure-activity relationships among DNA gyrase inhibitors. Synthesis and biological evaluation of 1,2-dihydro-4, 4-dimethyl-1-oxo-2-naphthalenecarboxylic acids as 1-carba bioisosteres of oxolinic acid.
Journal of medicinal chemistry 1984;27(3):306-10.