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Wei-Chiang Shen

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
7
Beloussow, Karin
6
Crandall, Edward
6
Kim, Kwang-Jin
6
Wang, Jeff
6
Zaro, Jennica
5
Shen, Li-Jiuan
5
Hakala, Thomas
5
Ballou, Byron
4
Ann, David
4
Widera, Adam
4
Borok, Zea
3
Bai, Yun
3
Hamm-Alvarez, Sarah
3
Ebbole, Daniel
3
Lim, Ching-Jou

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Publications

TOP 3
Huang Jing-Yang; Hu Hung-Tao; Shen Wei-Chiang
Phylogenetic study of two truffles, Tuber formosanum and Tuber furfuraceum, identified from Taiwan.
Zaro Jennica L; Vekich Jacqueline E; Tran Thuy; Shen Wei-Chiang
Nuclear localization of cell-penetrating peptides is dependent on endocytosis rather than cytosolic delivery in CHO cells.
Patel Leena N; Wang Jeffrey; Kim Kwang-Jin; Borok Zea; Crandall Edward D; Shen Wei-Chiang
Conjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin.

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All Publications

2009: Huang Jing-Yang; Hu Hung-Tao; Shen Wei-Chiang
Phylogenetic study of two truffles, Tuber formosanum and Tuber furfuraceum, identified from Taiwan.
FEMS microbiology letters 2009;294(2):157-71.
2009: Zaro Jennica L; Vekich Jacqueline E; Tran Thuy; Shen Wei-Chiang
Nuclear localization of cell-penetrating peptides is dependent on endocytosis rather than cytosolic delivery in CHO cells.
Molecular pharmaceutics 2009;6(2):337-44.
2009: Patel Leena N; Wang Jeffrey; Kim Kwang-Jin; Borok Zea; Crandall Edward D; Shen Wei-Chiang
Conjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin.
Molecular pharmaceutics 2009;6(2):492-503.
2009: Barnes Maureen P; Shen Wei-Chiang
Disulfide and thioether linked cytochrome c-oligoarginine conjugates in HeLa cells.
International journal of pharmaceutics 2009;369(1-2):79-84.
2009: Amet Nurmamet; Lee Hsin-Fang; Shen Wei-Chiang
Insertion of the designed helical linker led to increased expression of tf-based fusion proteins.
Pharmaceutical research 2009;26(3):523-8.
2008: Yuan Liyun; Wang Jeff; Shen Wei-Chiang
Reversible lipidization of somatostatin analogues for the liver targeting.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;70(2):615-20.
2008: Bahhady Rana; Kim Kwang-Jin; Borok Zea; Crandall Edward D; Shen Wei-Chiang
Characterization of protein factor(s) in rat bronchoalveolar lavage fluid that enhance insulin transport via transcytosis across primary rat alveolar epithelial cell monolayers.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;69(3):808-16.
2008: Yuan Liyun; Wang Jeff; Shen Wei-Chiang
Lipidization of human interferon-alpha: a new approach toward improving the delivery of protein drugs.
Journal of controlled release : official journal of the Controlled Release Society 2008;129(1):11-7.
2008: Patel Leena N; Uchiyama Tomomi; Kim Kwang-Jin; Borok Zea; Crandall Edward D; Shen Wei-Chiang; Lee Vincent H L
Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells.
Journal of pharmaceutical sciences 2008;97(6):2340-9.
2008: Norouziyan Fariba; Shen Wei-Chiang; Hamm-Alvarez Sarah F
Tyrphostin A8 stimulates a novel trafficking pathway of apically endocytosed transferrin through Rab11-enriched compartments in Caco-2 cells.
American journal of physiology. Cell physiology 2008;294(1):C7-21.
2007: Patel Leena N; Zaro Jennica L; Shen Wei-Chiang
Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives.
Pharmaceutical research 2007;24(11):1977-92.
2007: Lim Ching-Jou; Norouziyan Fariba; Shen Wei-Chiang
Accumulation of transferrin in Caco-2 cells: a possible mechanism of intestinal transferrin absorption.
Journal of controlled release : official journal of the Controlled Release Society 2007;122(3):393-8.
2007: Bahhady Rana; Kim Kwang-Jin; Borok Zea; Crandall Edward D; Shen Wei-Chiang
Enhancement of insulin transport across primary rat alveolar epithelial cell monolayers by endogenous cellular factor(s).
Pharmaceutical research 2007;24(9):1713-9.
2006: Bai Yun; Shen Wei-Chiang
Improving the oral efficacy of recombinant granulocyte colony-stimulating factor and transferrin fusion protein by spacer optimization.
Pharmaceutical research 2006;23(9):2116-21.
2006: Shen Li-Jiuan; Shen Wei-Chiang
Drug evaluation: ADI-PEG-20--a PEGylated arginine deiminase for arginine-auxotrophic cancers.
Current opinion in molecular therapeutics 2006;8(3):240-8.
2006: Zaro Jennica L; Rajapaksa Thejani E; Okamoto Curtis T; Shen Wei-Chiang
Membrane transduction of oligoarginine in HeLa cells is not mediated by macropinocytosis.
Molecular pharmaceutics 2006;3(2):181-6.
2006: Shen Li-Jiuan; Beloussow Karin; Shen Wei-Chiang
Modulation of arginine metabolic pathways as the potential anti-tumor mechanism of recombinant arginine deiminase.
Cancer letters 2006;231(1):30-5.
2005: Zaro Jennica L; Shen Wei-Chiang
Cytosolic delivery of a p16-peptide oligoarginine conjugate for inhibiting proliferation of MCF7 cells.
Journal of controlled release : official journal of the Controlled Release Society 2005;108(2-3):409-17.
2005: Lim Ching-Jou; Shen Wei-Chiang
Comparison of monomeric and oligomeric transferrin as potential carrier in oral delivery of protein drugs.
Journal of controlled release : official journal of the Controlled Release Society 2005;106(3):273-86.
2005: Zaro Jennica L; Shen Wei-Chiang
Evidence that membrane transduction of oligoarginine does not require vesicle formation.
Experimental cell research 2005;307(1):164-73.
2005: Bai Yun; Ann David K; Shen Wei-Chiang
Recombinant granulocyte colony-stimulating factor-transferrin fusion protein as an oral myelopoietic agent.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(20):7292-6.
2005: Lu Ying-Ku; Sun Kai-Hui; Shen Wei-Chiang
Blue light negatively regulates the sexual filamentation via the Cwc1 and Cwc2 proteins in Cryptococcus neoformans.
Molecular microbiology 2005;56(2):480-91.
2005: Yuan Liyun; Wang Jeff; Shen Wei-Chiang
Reversible lipidization prolongs the pharmacological effect, plasma duration, and liver retention of octreotide.
Pharmaceutical research 2005;22(2):220-7.
2005: Hsueh Yen-Ping; Shen Wei-Chiang
A homolog of Ste6, the a-factor transporter in Saccharomyces cerevisiae, is required for mating but not for monokaryotic fruiting in Cryptococcus neoformans.
Eukaryotic cell 2005;4(1):147-55.
2005: Shen Li-Jiuan; Beloussow Karin; Shen Wei-Chiang
Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway.
Biochemical pharmacology 2005;69(1):97-104.
2004: Lim Ching-Jou; Shen Wei-Chiang
Transferrin-oligomers as potential carriers in anticancer drug delivery.
Pharmaceutical research 2004;21(11):1985-92.
2004: Widera Adam; Bai Yun; Shen Wei-Chiang
The transepithelial transport of a G-CSF-transferrin conjugate in Caco-2 cells and its myelopoietic effect in BDF1 mice.
Pharmaceutical research 2004;21(2):278-84.
2003: Shen Li-Jiuan; Lin Wen-Chun; Beloussow Karin; Hosoya Ken-Ichi; Terasaki Tetsuya; Ann David K; Shen Wei-Chiang
Recombinant arginine deiminase as a differential modulator of inducible (iNOS) and endothelial (eNOS) nitric oxide synthetase activity in cultured endothelial cells.
Biochemical pharmacology 2003;66(10):1945-52.
2003: Widera A; Norouziyan F; Shen W-C
Mechanisms of TfR-mediated transcytosis and sorting in epithelial cells and applications toward drug delivery.
Advanced drug delivery reviews 2003;55(11):1439-66.
2003: Widera Adam; Kim Kwang-Jin J; Crandall Edward D; Shen Wei-Chiang
Transcytosis of GCSF-transferrin across rat alveolar epithelial cell monolayers.
Pharmaceutical research 2003;20(8):1231-8.
2003: Zaro Jennica L; Shen Wei-Chiang
Quantitative comparison of membrane transduction and endocytosis of oligopeptides.
Biochemical and biophysical research communications 2003;307(2):241-7.
2003: Widera A; Beloussow K; Kim K J; Crandall E D; Shen W C
Phenotype-dependent synthesis of transferrin receptor in rat alveolar epithelial cell monolayers.
Cell and tissue research 2003;312(3):313-8.
2003: Wang Jeff; Chow Donald; Heiati Hashem; Shen Wei-Chiang
Reversible lipidization for the oral delivery of salmon calcitonin.
Journal of controlled release : official journal of the Controlled Release Society 2003;88(3):369-80.
2003: Shen Li-Jiuan; Lin Wen-Chun; Beloussow Karin; Shen Wei-Chiang
Resistance to the anti-proliferative activity of recombinant arginine deiminase in cell culture correlates with the endogenous enzyme, argininosuccinate synthetase.
Cancer letters 2003;191(2):165-70.
2002: Shen Wei-Chiang
Pulmonary drug delivery.
IDrugs : the investigational drugs journal 2002;5(9):908-9.
2002: Beloussow Karin; Wang Li; Wu Jun; Ann David; Shen Wei Chiang
Recombinant arginine deiminase as a potential anti-angiogenic agent.
Cancer letters 2002;183(2):155-62.
2002: Wang Jeff; Wu Daphne; Shen Wei-Chiang
Structure-activity relationship of reversibly lipidized peptides: studies of fatty acid-desmopressin conjugates.
Pharmaceutical research 2002;19(5):609-14.
2001: Du X; Beloussow K; Shen W C
Bowman-Birk protease inhibitor and its palmitic acid conjugate prevent 7,12-dimethylbenz[a]anthracene-induced transformation in cultured mouse mammary glands.
Cancer letters 2001;164(2):135-41.
2001: Xia C Q; Shen W C
Tyrphostin-8 enhances transferrin receptor-mediated transcytosis in Caco-2- cells and inreases hypoglycemic effect of orally administered insulin-transferrin conjugate in diabetic rats.
Pharmaceutical research 2001;18(2):191-5.
2000: Xia C Q; Wang J; Shen W C
Hypoglycemic effect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats.
The Journal of pharmacology and experimental therapeutics 2000;295(2):594-600.
2000: Wang J; Shen W C
Gastric retention and stability of lipidized Bowman-Birk protease inhibitor in mice.
International journal of pharmaceutics 2000;204(1-2):111-6.
1999: Wang J; Shen D; Shen W C
Preparation, purification, and characterization of a reversibly lipidized desmopressin with potentiated anti-diuretic activity.
Pharmaceutical research 1999;16(11):1674-9.
1999: Shen W C
Frontiers of drug development. 26-28 July 1999, Pasadena, CA, USA.
IDrugs : the investigational drugs journal 1999;2(10):1002-4.
1999: Shen W C; Bobrowicz P; Ebbole D J
Isolation of pheromone precursor genes of Magnaporthe grisea.
Fungal genetics and biology : FG & B 1999;27(2-3):253-63.
1998: Yeung A K; Basu S K; Wu S K; Chu C; Okamoto C T; Hamm-Alvarez S F; von Grafenstein H; Shen W C; Kim K J; Bolger M B; Haworth I S; Ann D K; Lee V H
Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton- coupled dipeptide transporter (hPepT1).
Biochemical and biophysical research communications 1998;250(1):103-7.
1998: Shen W C; Wieser J; Adams T H; Ebbole D J
The Neurospora rca-1 gene complements an Aspergillus flbD sporulation mutant but has no identifiable role in Neurospora sporulation.
Genetics 1998;148(3):1031-41.
1997: Shen W C; Ebbole D J
Cross-pathway and pathway-specific control of amino acid biosynthesis in Magnaporthe grisea.
Fungal genetics and biology : FG & B 1997;21(1):40-9.
1997: Shen W C
Nuclear import of DNA--the ultimate targeting in gene therapy.
Journal of drug targeting 1997;5(1):11-3.
1996: Shah D; Shen W C
Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells.
Journal of pharmaceutical sciences 1996;85(12):1306-11.
1996: Hamm-Alvarez S F; Sonee M; Loran-Goss K; Shen W C
Paclitaxel and nocodazole differentially alter endocytosis in cultured cells.
Pharmaceutical research 1996;13(11):1647-56.
1996: Honeycutt L; Wang J; Ekrami H; Shen W C
Comparison of pharmacokinetic parameters of a polypeptide, the Bowman-Birk protease inhibitor (BBI), and its palmitic acid conjugate.
Pharmaceutical research 1996;13(9):1373-7.
1995: Ekrami H M; Kennedy A R; Shen W C
Water-soluble fatty acid derivatives as acylating agents for reversible lipidization of polypeptides.
FEBS letters 1995;371(3):283-6.
1995: Gladysheva I P; Polekhina O V; Shen W C; Shevchenko A A; Kazanskaia N F; Larionova N I
[Structure and biological properties of a conjugate of Bowman-Birk type soy proteinase inhibitor with a block copolymer of ethylene oxide and propylene oxide]
Biokhimii?a (Moscow, Russia) 1995;60(4):523-32.
1995: Ekrami H; Kennedy A R; Shen W C
Disposition of positively charged Bowman-Birk protease inhibitor conjugates in mice: influence of protein conjugate charge density and size on lung targeting.
Journal of pharmaceutical sciences 1995;84(4):456-61.
1995: Shah D; Shen W C
The paradox of transferrin receptor-mediated drug delivery--intracellular targeting or transcellular transport?
Journal of drug targeting 1995;3(4):243-5.
1995: Ekrami H M; Shen W C
Carbamylation decreases the cytotoxicity but not the drug-carrier properties of polylysines.
Journal of drug targeting 1995;2(6):469-75.
1994: Taub M E; Wan J; Shen W C
Transepithelial transport of tyramine across filter-grown MDCK cells via a poly(D-lysine) carrier.
Pharmaceutical research 1994;11(9):1250-6.
1994: Shah D; Shen W C
The establishment of polarity and enhanced transcytosis of transferrin receptors in enterocyte-like Caco-2 cells.
Journal of drug targeting 1994;2(2):93-9.
1993: Taub M E; Shen W C
Regulation of pathways within cultured epithelial cells for the transcytosis of a basal membrane-bound peroxidase-polylysine conjugate.
Journal of cell science 1993;106 ( Pt 4)():1313-21.
1993: Ekrami H; Kennedy A R; Witschi H; Shen W C
Cationized Bowman-Birk protease inhibitor as a targeted cancer chemopreventive agent.
Journal of drug targeting 1993;1(1):41-9.
1992: Wan J; Taub M E; Shah D; Shen W C
Brefeldin A enhances receptor-mediated transcytosis of transferrin in filter-grown Madin-Darby canine kidney cells.
The Journal of biological chemistry 1992;267(19):13446-50.
1992: Taub M E; Shen W C
Polarity in the transcytotic processing of apical and basal membrane-bound peroxidase-polylysine conjugates in MDCK cells.
Journal of cellular physiology 1992;150(2):283-90.
1992: Ballou B; Jaffe R; Persiani S; Shen W C; Langone J J; Sands H; Reilandu J M; Curley J; Hakala T R
Tissue localization of methotrexate-monoclonal-IgM immunoconjugates: anti-SSEA-1 and MOPC 104E in mouse teratocarcinomas and normal tissues.
Cancer immunology, immunotherapy : CII 1992;35(4):251-6.
1991: Persiani S; Yeung A; Shen W C; Kennedy A R
Polylysine conjugates of Bowman-Birk protease inhibitor as targeted anti-carcinogenic agents.
Carcinogenesis 1991;12(6):1149-52.
1991: Lin Y J; Shen W C
Effects of deoxycholate on the transepithelial transport of sucrose and horseradish peroxidase in filter-grown Madin-Darby canine kidney (MDCK) cells.
Pharmaceutical research 1991;8(4):498-501.
1990: Wan J S; Persiani S; Shen W C
Transcellular processing of disulfide- and thioether-linked peroxidase--polylysine conjugates in cultured MDCK epithelial cells.
Journal of cellular physiology 1990;145(1):9-15.
1990: Shen W C
Acid-sensitive dissociation between poly(lysine) and histamine-modified poly(glutamate) as a model for drug-releasing from carriers in endosomes.
Biochimica et biophysica acta 1990;1034(1):122-4.
1990: Shen W C; Wan J S; Shen D
Proteolytic processing in a non-lysosomal compartment is required for transcytosis of protein-polylysine conjugates in cultured Madin-Darby canine kidney cells.
Biochemical and biophysical research communications 1990;166(1):316-23.
1990: Shen W C; Persiani S; Ballou B; Hakala T R
Antibodies as drug carriers for solid tumors: evaluation of drug-anti-SSEA-1 conjugates in the treatment of teratocarcinoma.
Targeted diagnosis and therapy 1990;3():289-304.
1989: Persiani S; Shen W C
Increase of poly(L-lysine) uptake but not fluid phase endocytosis in neuraminidase pretreated Madin-Darby canine kidney (MDCK) cells.
Life sciences 1989;45(26):2605-10.
1989: Persiani S; Ballou B; Shen W C; Ryser H J; Reiland J M; Hakala T R
In vivo antitumor effect of methotrexate conjugated to a monoclonal IgM antibody specific for stage-specific embryonic antigen-1, on MH-15 mouse teratocarcinoma.
Cancer immunology, immunotherapy : CII 1989;29(3):167-70.
1986: Shen W C; Ballou B; Ryser H J; Hakala T R
Targeting, internalization, and cytotoxicity of methotrexate-monoclonal anti-stage-specific embryonic antigen-1 antibody conjugates in cultured F-9 teratocarcinoma cells.
Cancer research 1986;46(8):3912-6.
1986: Ballou B; Reiland J M; Levine G; Taylor R J; Shen W C; Ryser H J; Solter D; Hakala T R
Tumor location and drug targeting using a monoclonal antibody (anti-SSEA-1) and antigen-binding fragments.
Journal of surgical oncology 1986;31(1):1-12.

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