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Wei-Chiang Shen

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TOP 3
Randall Kenien; Wei-Chiang Shen; Jennica L Zaro
Vesicle-to-cytosol transport of disulfide-linked cargo mediated by an amphipathic cell-penetrating peptide.
Xiaoying Chen; Jennica L Zaro; Wei-Chiang Shen
Pharmacokinetics of recombinant bifunctional fusion proteins.
Randall Kenien; Jennica L Zaro; Wei-Chiang Shen
MAP-mediated nuclear delivery of a cargo protein.

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All Publications

2012: Randall Kenien; Wei-Chiang Shen; Jennica L Zaro
Vesicle-to-cytosol transport of disulfide-linked cargo mediated by an amphipathic cell-penetrating peptide.
Journal of drug targeting 2012;20(9):793-800.
2012: Xiaoying Chen; Jennica L Zaro; Wei-Chiang Shen
Pharmacokinetics of recombinant bifunctional fusion proteins.
Expert opinion on drug metabolism & toxicology 2012;8(5):581-95.
2012: Randall Kenien; Jennica L Zaro; Wei-Chiang Shen
MAP-mediated nuclear delivery of a cargo protein.
Journal of drug targeting 2012;20(4):329-37.
2012: Robert H Mo; Jing-Hsiung James Ou; Jennica L Zaro; Wei-Chiang Shen
Effects of Lipofectamine 2000/siRNA complexes on autophagy in hepatoma cells.
Molecular biotechnology 2012;51(1):1-8.
2012: Jennica L Zaro; Likun Fei; Wei-Chiang Shen
Recombinant peptide constructs for targeted cell penetrating peptide-mediated delivery.
Journal of controlled release : official journal of the Controlled Release Society 2012;158(3):357-61.
2012: Robert H Mo; Jennica L Zaro; Wei-Chiang Shen
Comparison of cationic and amphipathic cell penetrating peptides for siRNA delivery and efficacy.
Molecular pharmaceutics 2012;9(2):299-309.
2012: Deshui Zhang; Jennica L Zaro; Ning Huang; Hsin-Fang Lee; Steven C Pettit; Wei-Chiang Shen
Characterization of transferrin receptor-mediated endocytosis and cellular iron delivery of recombinant human serum transferrin from rice (Oryza sativa L.).
BMC biotechnology 2012;12():92.
2011: Yan Wang; Jennica L Zaro; Yu-Sheng Chen; Wei-Chiang Shen
Receptor-mediated activation of a proinsulin-transferrin fusion protein in hepatoma cells.
Journal of controlled release : official journal of the Controlled Release Society 2011;155(3):386-92.
2011: Likun Fei; Ling Ren; Jennica L Zaro; Wei-Chiang Shen
The influence of net charge and charge distribution on cellular uptake and cytosolic localization of arginine-rich peptides.
Journal of drug targeting 2011;19(8):675-80.
2011: Xiaoying Chen; Hsin-Fang Lee; Jennica L Zaro; Wei-Chiang Shen
Effects of receptor binding on plasma half-life of bifunctional transferrin fusion proteins.
Molecular pharmaceutics 2011;8(2):457-65.
2011: Vivian Hsiu-Chuan Liao; Yu-Ju Chu; Yu-Chen Su; Sung-Yun Hsiao; Chia-Cheng Wei; Chen-Wuing Liu; Chung-Min Liao; Wei-Chiang Shen; Fi-John Chang
Arsenite-oxidizing and arsenate-reducing bacteria associated with arsenic-rich groundwater in Taiwan.
Journal of contaminant hydrology 2011;123(1-2):20-9.
2011: Kuang-Hung Liu; Wei-Chiang Shen
Mating differentiation in Cryptococcus neoformans is negatively regulated by the Crk1 protein kinase.
Fungal genetics and biology : FG & B 2011;48(3):225-40.
2011: Lin-Ing Wang; Yu-Sheng Lin; Kung-Hung Liu; Ambrose Y Jong; Wei-Chiang Shen
Cryptococcus neoformans mediator protein Ssn8 negatively regulates diverse physiological processes and is required for virulence.
PloS one 2011;6(4):e19162.
2010: Xiaoying Chen; Yun Bai; Jennica L Zaro; Wei-Chiang Shen
Design of an in vivo cleavable disulfide linker in recombinant fusion proteins.
BioTechniques 2010;49(1):513-8.
2010: Nurmamet Amet; Wei Wang; Wei-Chiang Shen
Human growth hormone-transferrin fusion protein for oral delivery in hypophysectomized rats.
Journal of controlled release : official journal of the Controlled Release Society 2010;141(2):177-82.
2009: Jing-Yang Huang; Hung-Tao Hu; Wei-Chiang Shen
Phylogenetic study of two truffles, Tuber formosanum and Tuber furfuraceum, identified from Taiwan.
FEMS microbiology letters 2009;294(2):157-71.
2009: Maureen P Barnes; Wei-Chiang Shen
Disulfide and thioether linked cytochrome c-oligoarginine conjugates in HeLa cells.
International journal of pharmaceutics 2009;369(1-2):79-84.
2009: Jennica L Zaro; Jacqueline E Vekich; Thuy Tran; Wei-Chiang Shen
Nuclear localization of cell-penetrating peptides is dependent on endocytosis rather than cytosolic delivery in CHO cells.
Molecular pharmaceutics 2009;6(2):337-44.
2009: Leena N Patel; Jeffrey Wang; Kwang-Jin Kim; Zea Borok; Edward D Crandall; Wei-Chiang Shen
Conjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin.
Molecular pharmaceutics 2009;6(2):492-503.
2009: Nurmamet Amet; Hsin-Fang Lee; Wei-Chiang Shen
Insertion of the designed helical linker led to increased expression of tf-based fusion proteins.
Pharmaceutical research 2009;26(3):523-8.
2008: Liyun Yuan; Jeff Wang; Wei-Chiang Shen
Reversible lipidization of somatostatin analogues for the liver targeting.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;70(2):615-20.
2008: Rana Bahhady; Kwang-Jin Kim; Zea Borok; Edward D Crandall; Wei-Chiang Shen
Characterization of protein factor(s) in rat bronchoalveolar lavage fluid that enhance insulin transport via transcytosis across primary rat alveolar epithelial cell monolayers.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;69(3):808-16.
2008: Liyun Yuan; Jeff Wang; Wei-Chiang Shen
Lipidization of human interferon-alpha: a new approach toward improving the delivery of protein drugs.
Journal of controlled release : official journal of the Controlled Release Society 2008;129(1):11-7.
2008: Leena N Patel; Tomomi Uchiyama; Kwang-Jin Kim; Zea Borok; Edward D Crandall; Wei-Chiang Shen; Vincent H L Lee
Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells.
Journal of pharmaceutical sciences 2008;97(6):2340-9.
2008: Fariba Norouziyan; Wei-Chiang Shen; Sarah F Hamm-Alvarez
Tyrphostin A8 stimulates a novel trafficking pathway of apically endocytosed transferrin through Rab11-enriched compartments in Caco-2 cells.
American journal of physiology. Cell physiology 2008;294(1):C7-21.
2007: Leena N Patel; Jennica L Zaro; Wei-Chiang Shen
Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives.
Pharmaceutical research 2007;24(11):1977-92.
2007: Ching-Jou Lim; Fariba Norouziyan; Wei-Chiang Shen
Accumulation of transferrin in Caco-2 cells: a possible mechanism of intestinal transferrin absorption.
Journal of controlled release : official journal of the Controlled Release Society 2007;122(3):393-8.
2007: Rana Bahhady; Kwang-Jin Kim; Zea Borok; Edward D Crandall; Wei-Chiang Shen
Enhancement of insulin transport across primary rat alveolar epithelial cell monolayers by endogenous cellular factor(s).
Pharmaceutical research 2007;24(9):1713-9.
2006: Yun Bai; Wei-Chiang Shen
Improving the oral efficacy of recombinant granulocyte colony-stimulating factor and transferrin fusion protein by spacer optimization.
Pharmaceutical research 2006;23(9):2116-21.
2006: Li-Jiuan Shen; Wei-Chiang Shen
Drug evaluation: ADI-PEG-20--a PEGylated arginine deiminase for arginine-auxotrophic cancers.
Current opinion in molecular therapeutics 2006;8(3):240-8.
2006: Jennica L Zaro; Thejani E Rajapaksa; Curtis T Okamoto; Wei-Chiang Shen
Membrane transduction of oligoarginine in HeLa cells is not mediated by macropinocytosis.
Molecular pharmaceutics 2006;3(2):181-6.
2006: Li-Jiuan Shen; Karin Beloussow; Wei-Chiang Shen
Modulation of arginine metabolic pathways as the potential anti-tumor mechanism of recombinant arginine deiminase.
Cancer letters 2006;231(1):30-5.
2005: Jennica L Zaro; Wei-Chiang Shen
Cytosolic delivery of a p16-peptide oligoarginine conjugate for inhibiting proliferation of MCF7 cells.
Journal of controlled release : official journal of the Controlled Release Society 2005;108(2-3):409-17.
2005: Ching-Jou Lim; Wei-Chiang Shen
Comparison of monomeric and oligomeric transferrin as potential carrier in oral delivery of protein drugs.
Journal of controlled release : official journal of the Controlled Release Society 2005;106(3):273-86.
2005: Jennica L Zaro; Wei-Chiang Shen
Evidence that membrane transduction of oligoarginine does not require vesicle formation.
Experimental cell research 2005;307(1):164-73.
2005: Yun Bai; David K Ann; Wei-Chiang Shen
Recombinant granulocyte colony-stimulating factor-transferrin fusion protein as an oral myelopoietic agent.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(20):7292-6.
2005: Ying-Ku Lu; Kai-Hui Sun; Wei-Chiang Shen
Blue light negatively regulates the sexual filamentation via the Cwc1 and Cwc2 proteins in Cryptococcus neoformans.
Molecular microbiology 2005;56(2):480-91.
2005: Liyun Yuan; Jeff Wang; Wei-Chiang Shen
Reversible lipidization prolongs the pharmacological effect, plasma duration, and liver retention of octreotide.
Pharmaceutical research 2005;22(2):220-7.
2005: Yen-Ping Hsueh; Wei-Chiang Shen
A homolog of Ste6, the a-factor transporter in Saccharomyces cerevisiae, is required for mating but not for monokaryotic fruiting in Cryptococcus neoformans.
Eukaryotic cell 2005;4(1):147-55.
2005: Li-Jiuan Shen; Karin Beloussow; Wei-Chiang Shen
Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway.
Biochemical pharmacology 2005;69(1):97-104.
2004: Ching-Jou Lim; Wei-Chiang Shen
Transferrin-oligomers as potential carriers in anticancer drug delivery.
Pharmaceutical research 2004;21(11):1985-92.
2004: Adam Widera; Yun Bai; Wei-Chiang Shen
The transepithelial transport of a G-CSF-transferrin conjugate in Caco-2 cells and its myelopoietic effect in BDF1 mice.
Pharmaceutical research 2004;21(2):278-84.
2003: Li-Jiuan Shen; Wen-Chun Lin; Karin Beloussow; Ken-Ichi Hosoya; Tetsuya Terasaki; David K Ann; Wei-Chiang Shen
Recombinant arginine deiminase as a differential modulator of inducible (iNOS) and endothelial (eNOS) nitric oxide synthetase activity in cultured endothelial cells.
Biochemical pharmacology 2003;66(10):1945-52.
2003: Adam Widera; F Norouziyan; Wei-Chiang Shen
Mechanisms of TfR-mediated transcytosis and sorting in epithelial cells and applications toward drug delivery.
Advanced drug delivery reviews 2003;55(11):1439-66.
2003: Adam Widera; Kwang-Jin J Kim; Edward D Crandall; Wei-Chiang Shen
Transcytosis of GCSF-transferrin across rat alveolar epithelial cell monolayers.
Pharmaceutical research 2003;20(8):1231-8.
2003: Jennica L Zaro; Wei-Chiang Shen
Quantitative comparison of membrane transduction and endocytosis of oligopeptides.
Biochemical and biophysical research communications 2003;307(2):241-7.
2003: Adam Widera; Karin Beloussow; Kwang-Jin Kim; Edward D Crandall; Wei-Chiang Shen
Phenotype-dependent synthesis of transferrin receptor in rat alveolar epithelial cell monolayers.
Cell and tissue research 2003;312(3):313-8.
2003: Jeff Wang; Donald Chow; Hashem Heiati; Wei-Chiang Shen
Reversible lipidization for the oral delivery of salmon calcitonin.
Journal of controlled release : official journal of the Controlled Release Society 2003;88(3):369-80.
2003: Li-Jiuan Shen; Wen-Chun Lin; Karin Beloussow; Wei-Chiang Shen
Resistance to the anti-proliferative activity of recombinant arginine deiminase in cell culture correlates with the endogenous enzyme, argininosuccinate synthetase.
Cancer letters 2003;191(2):165-70.
2002: Karin Beloussow; Li Wang; Jun Wu; David K Ann; Wei-Chiang Shen
Recombinant arginine deiminase as a potential anti-angiogenic agent.
Cancer letters 2002;183(2):155-62.
2002: Wei-Chiang Shen
Pulmonary drug delivery.
IDrugs : the investigational drugs journal 2002;5(9):908-9.
2002: Jeff Wang; Daphne Wu; Wei-Chiang Shen
Structure-activity relationship of reversibly lipidized peptides: studies of fatty acid-desmopressin conjugates.
Pharmaceutical research 2002;19(5):609-14.
2001: X Du; Karin Beloussow; Wei-Chiang Shen
Bowman-Birk protease inhibitor and its palmitic acid conjugate prevent 7,12-dimethylbenz[a]anthracene-induced transformation in cultured mouse mammary glands.
Cancer letters 2001;164(2):135-41.
2001: Cindy Xia; Wei-Chiang Shen
Tyrphostin-8 enhances transferrin receptor-mediated transcytosis in Caco-2- cells and inreases hypoglycemic effect of orally administered insulin-transferrin conjugate in diabetic rats.
Pharmaceutical research 2001;18(2):191-5.
2000: Cindy Xia; J Wang; Wei-Chiang Shen
Hypoglycemic effect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats.
The Journal of pharmacology and experimental therapeutics 2000;295(2):594-600.
2000: Jiafang Wang; Wei-Chiang Shen
Gastric retention and stability of lipidized Bowman-Birk protease inhibitor in mice.
International journal of pharmaceutics 2000;204(1-2):111-6.
1999: Jeff Wang; D Shen; Wei-Chiang Shen
Preparation, purification, and characterization of a reversibly lipidized desmopressin with potentiated anti-diuretic activity.
Pharmaceutical research 1999;16(11):1674-9.
1999: Wei-Chiang Shen
Frontiers of drug development. 26-28 July 1999, Pasadena, CA, USA.
IDrugs : the investigational drugs journal 1999;2(10):1002-4.
1999: Wei-Chiang Shen; Piotr Bobrowicz; Daniel J Ebbole
Isolation of pheromone precursor genes of Magnaporthe grisea.
Fungal genetics and biology : FG & B 1999;27(2-3):253-63.
1998: AK Yeung; SK Basu; Sharon K Wu; C Chu; Curtis T Okamoto; Sarah F Hamm-Alvarez; Hermann von Grafenstein; Wei-Chiang Shen; Kwang-Jin Kim; Michael B Bolger; Ian S Haworth; David K Ann; Vincent H L Lee
Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton- coupled dipeptide transporter (hPepT1).
Biochemical and biophysical research communications 1998;250(1):103-7.
1998: Wei-Chiang Shen; JK Wieser; TH Adams; Daniel J Ebbole
The Neurospora rca-1 gene complements an Aspergillus flbD sporulation mutant but has no identifiable role in Neurospora sporulation.
Genetics 1998;148(3):1031-41.
1997: Wei-Chiang Shen; Daniel J Ebbole
Cross-pathway and pathway-specific control of amino acid biosynthesis in Magnaporthe grisea.
Fungal genetics and biology : FG & B 1997;21(1):40-9.
1997: Wei-Chiang Shen
Nuclear import of DNA--the ultimate targeting in gene therapy.
Journal of drug targeting 1997;5(1):11-3.
1996: D Shah; Wei-Chiang Shen
Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells.
Journal of pharmaceutical sciences 1996;85(12):1306-11.
1996: Sarah F Hamm-Alvarez; M Sonee; K Loran-Goss; Wei-Chiang Shen
Paclitaxel and nocodazole differentially alter endocytosis in cultured cells.
Pharmaceutical research 1996;13(11):1647-56.
1996: L Honeycutt; J Wang; H Ekrami; Wei-Chiang Shen
Comparison of pharmacokinetic parameters of a polypeptide, the Bowman-Birk protease inhibitor (BBI), and its palmitic acid conjugate.
Pharmaceutical research 1996;13(9):1373-7.
1995: H M Ekrami; A R Kennedy; Wei-Chiang Shen
Water-soluble fatty acid derivatives as acylating agents for reversible lipidization of polypeptides.
FEBS letters 1995;371(3):283-6.
1995: Inna Gladysheva; O V Polekhina; Wei-Chiang Shen; A A Shevchenko; N F Kazanskaia; Natalia I Larionova
[Structure and biological properties of a conjugate of Bowman-Birk type soy proteinase inhibitor with a block copolymer of ethylene oxide and propylene oxide].
Biokhimii͡a (Moscow, Russia) 1995;60(4):523-32.
1995: H Ekrami; A R Kennedy; Wei-Chiang Shen
Disposition of positively charged Bowman-Birk protease inhibitor conjugates in mice: influence of protein conjugate charge density and size on lung targeting.
Journal of pharmaceutical sciences 1995;84(4):456-61.
1995: D Shah; Wei-Chiang Shen
The paradox of transferrin receptor-mediated drug delivery--intracellular targeting or transcellular transport?
Journal of drug targeting 1995;3(4):243-5.
1995: H M Ekrami; Wei-Chiang Shen
Carbamylation decreases the cytotoxicity but not the drug-carrier properties of polylysines.
Journal of drug targeting 1995;2(6):469-75.
1994: M E Taub; J Wan; Wei-Chiang Shen
Transepithelial transport of tyramine across filter-grown MDCK cells via a poly(D-lysine) carrier.
Pharmaceutical research 1994;11(9):1250-6.
1994: D Shah; Wei-Chiang Shen
The establishment of polarity and enhanced transcytosis of transferrin receptors in enterocyte-like Caco-2 cells.
Journal of drug targeting 1994;2(2):93-9.
1993: M E Taub; Wei-Chiang Shen
Regulation of pathways within cultured epithelial cells for the transcytosis of a basal membrane-bound peroxidase-polylysine conjugate.
Journal of cell science 1993;106 ( Pt 4)():1313-21.
1993: H Ekrami; A R Kennedy; H Witschi; Wei-Chiang Shen
Cationized Bowman-Birk protease inhibitor as a targeted cancer chemopreventive agent.
Journal of drug targeting 1993;1(1):41-9.
1992: J Wan; M E Taub; D Shah; Wei-Chiang Shen
Brefeldin A enhances receptor-mediated transcytosis of transferrin in filter-grown Madin-Darby canine kidney cells.
The Journal of biological chemistry 1992;267(19):13446-50.
1992: M E Taub; Wei-Chiang Shen
Polarity in the transcytotic processing of apical and basal membrane-bound peroxidase-polylysine conjugates in MDCK cells.
Journal of cellular physiology 1992;150(2):283-90.
1992: Byron Ballou; R Jaffe; S Persiani; Wei-Chiang Shen; J J Langone; H Sands; J M Reilandu; J Curley; Thomas R Hakala
Tissue localization of methotrexate-monoclonal-IgM immunoconjugates: anti-SSEA-1 and MOPC 104E in mouse teratocarcinomas and normal tissues.
Cancer immunology, immunotherapy : CII 1992;35(4):251-6.
1991: S Persiani; A Yeung; Wei-Chiang Shen; A R Kennedy
Polylysine conjugates of Bowman-Birk protease inhibitor as targeted anti-carcinogenic agents.
Carcinogenesis 1991;12(6):1149-52.
1991: Y J Lin; Wei-Chiang Shen
Effects of deoxycholate on the transepithelial transport of sucrose and horseradish peroxidase in filter-grown Madin-Darby canine kidney (MDCK) cells.
Pharmaceutical research 1991;8(4):498-501.
1990: J S Wan; S Persiani; Wei-Chiang Shen
Transcellular processing of disulfide- and thioether-linked peroxidase--polylysine conjugates in cultured MDCK epithelial cells.
Journal of cellular physiology 1990;145(1):9-15.
1990: Wei-Chiang Shen
Acid-sensitive dissociation between poly(lysine) and histamine-modified poly(glutamate) as a model for drug-releasing from carriers in endosomes.
Biochimica et biophysica acta 1990;1034(1):122-4.
1990: Wei-Chiang Shen; J S Wan; D Shen
Proteolytic processing in a non-lysosomal compartment is required for transcytosis of protein-polylysine conjugates in cultured Madin-Darby canine kidney cells.
Biochemical and biophysical research communications 1990;166(1):316-23.
1990: Wei-Chiang Shen; S Persiani; Byron Ballou; Thomas R Hakala
Antibodies as drug carriers for solid tumors: evaluation of drug-anti-SSEA-1 conjugates in the treatment of teratocarcinoma.
Targeted diagnosis and therapy 1990;3():289-304.
1989: S Persiani; Wei-Chiang Shen
Increase of poly(L-lysine) uptake but not fluid phase endocytosis in neuraminidase pretreated Madin-Darby canine kidney (MDCK) cells.
Life sciences 1989;45(26):2605-10.
1989: S Persiani; Byron Ballou; Wei-Chiang Shen; H J Ryser; J M Reiland; Thomas R Hakala
In vivo antitumor effect of methotrexate conjugated to a monoclonal IgM antibody specific for stage-specific embryonic antigen-1, on MH-15 mouse teratocarcinoma.
Cancer immunology, immunotherapy : CII 1989;29(3):167-70.
1986: Wei-Chiang Shen; Byron Ballou; H J Ryser; Thomas R Hakala
Targeting, internalization, and cytotoxicity of methotrexate-monoclonal anti-stage-specific embryonic antigen-1 antibody conjugates in cultured F-9 teratocarcinoma cells.
Cancer research 1986;46(8):3912-6.
1986: Byron Ballou; J M Reiland; G Levine; R J Taylor; Wei-Chiang Shen; H J Ryser; D Solter; Thomas R Hakala
Tumor location and drug targeting using a monoclonal antibody (anti-SSEA-1) and antigen-binding fragments.
Journal of surgical oncology 1986;31(1):1-12.