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Elizabeth Shephard

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TOP 3
Mina Edwards; Lyndsey Houseman; Ian R Phillips; Elizabeth A Shephard
Isolation of mouse hepatocytes.
Matthew Hancock; Elizabeth A Shephard
Detection of regulatory polymorphisms: high-throughput capillary DNase I footprinting.
Elizabeth A Shephard; Eileen P Treacy; Ian R Phillips
Clinical utility gene card for: trimethylaminuria.

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All Publications

2013: Mina Edwards; Lyndsey Houseman; Ian R Phillips; Elizabeth A Shephard
Isolation of mouse hepatocytes.
Methods in molecular biology (Clifton, N.J.) 2013;987():283-93.
2013: Matthew Hancock; Elizabeth A Shephard
Detection of regulatory polymorphisms: high-throughput capillary DNase I footprinting.
Methods in molecular biology (Clifton, N.J.) 2013;987():269-82.
2012: Elizabeth A Shephard; Eileen P Treacy; Ian R Phillips
Clinical utility gene card for: trimethylaminuria.
European journal of human genetics : EJHG 2012;20(3):.
2010: Elizabeth A Shephard; Ian R Phillips
The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism.
Expert opinion on drug metabolism & toxicology 2010;6(9):1083-94.
2009: Charles Allerston; H H Vetti; Gunnar Houge; Ian R Phillips; Elizabeth A Shephard
A novel mutation in the flavin-containing monooxygenase 3 gene (FMO3) of a Norwegian family causes trimethylaminuria.
Molecular genetics and metabolism 2009;98(1-2):198-202.
2009: Diana Hernandez; Azara Janmohamed; Pritpal Chandan; Bilal A Omar; Ian R Phillips; Elizabeth A Shephard
Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine.
Pharmacogenetics and genomics 2009;19(4):289-99.
2008: Krishna R Veeramah; Mark Thomas; Michael E Weale; David Zeitlyn; Ayele Tarekegn; Endashaw Bekele; Nancy R Mendell; Elizabeth A Shephard; Neil Bradman; Ian R Phillips
The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa.
Pharmacogenetics and genomics 2008;18(10):877-86.
2008: Ian R Phillips; Elizabeth A Shephard
Flavin-containing monooxygenases: mutations, disease and drug response.
Trends in pharmacological sciences 2008;29(6):294-301.
2007: Charles Allerston; Makiko Shimizu; Masaki Fujieda; Elizabeth A Shephard; Hiroshi Yamazaki; Ian R Phillips
Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3).
Pharmacogenetics and genomics 2007;17(10):827-39.
2007: Elizabeth A Shephard; Pritpal Chandan; Milena Stevanovic-Walker; Mina Edwards; Ian R Phillips
Alternative promoters and repetitive DNA elements define the species-dependent tissue-specific expression of the FMO1 genes of human and mouse.
The Biochemical journal 2007;406(3):491-9.
2006: Diana Hernandez; Anna N Melidoni; lan R Phillips; Elizabeth A Shephard
Microinjection of targeted embryonic stem cells and establishment of knockout mouse lines for Fmo genes.
Methods in molecular biology (Clifton, N.J.) 2006;320():329-41.
2006: Diana Hernandez; lan R Phillips; Elizabeth A Shephard
Characterization of targeted mouse embryonic stem cell chromosomes: karyotyping and fluorescence in situ hybridization of metaphase spreads.
Methods in molecular biology (Clifton, N.J.) 2006;320():321-7.
2006: Diana Hernandez; Pritpal Chandan; Azara Janmohamed; lan R Phillips; Elizabeth A Shephard
Deletion of genes from the mouse genome using Cre/loxP technology.
Methods in molecular biology (Clifton, N.J.) 2006;320():307-19.
2006: Azara Janmohamed; lan R Phillips; Elizabeth A Shephard
Determination of cellular localization of expression of flavin-containing monooxygenase genes in mouse tissues by in situ hybridization.
Methods in molecular biology (Clifton, N.J.) 2006;320():295-305.
2006: Mina Edwards; Siew-Cheng Wong; Roongsiri Chotpadiwetkul; Despina Smirlis; lan R Phillips; Elizabeth A Shephard
Transfection of primary cultures of rat hepatocytes.
Methods in molecular biology (Clifton, N.J.) 2006;320():273-82.
2006: Azara Janmohamed; Prapimpuk Thaunsukon; Elizabeth A Shephard; lan R Phillips
Expression of recombinant flavin-containing monooxygenases in a baculovirus/insect cell system.
Methods in molecular biology (Clifton, N.J.) 2006;320():39-59.
2004: Azara Janmohamed; Diana Hernandez; Ian R Phillips; Elizabeth A Shephard
Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (Fmos).
Biochemical pharmacology 2004;68(1):73-83.
2004: Diana Hernandez; Azara Janmohamed; Pritpal Chandan; Ian R Phillips; Elizabeth A Shephard
Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters.
Pharmacogenetics 2004;14(2):117-30.
2003: Diana Hernandez; Sarah Addou; David Lee; Christine Orengo; Elizabeth A Shephard; Ian R Phillips
Trimethylaminuria and a human FMO3 mutation database.
Human mutation 2003;22(3):209-13.
2002: Sharon K Krueger; David E Williams; Mei-Fei Yueh; Sarah R Martin; Ronald Hines; Judy L Raucy; Colin T Dolphin; Elizabeth A Shephard; Ian R Phillips
Genetic polymorphisms of flavin-containing monooxygenase (FMO).
Drug metabolism reviews 2002;34(3):523-32.
2001: Azara Janmohamed; Colin T Dolphin; Ian R Phillips; Elizabeth A Shephard
Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450.
Biochemical pharmacology 2001;62(6):777-86.
2001: Tamara Vanhaecke; André Foriers; A Geerts; Elizabeth A Shephard; A Vercruysse; Vera Rogiers
Pyruvate-induced long-term maintenance of glutathione s-transferase in rat hepatocyte cultures.
Alternatives to laboratory animals : ATLA 2001;29(3):335-46.
2001: Despina Smirlis; Roongsiri Muangmoonchai; Mina Edwards; Ian R Phillips; Elizabeth A Shephard
Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics.
The Journal of biological chemistry 2001;276(16):12822-6.
2001: Roongsiri Muangmoonchai; Despina Smirlis; Siew-Cheng Wong; Mina Edwards; Ian R Phillips; Elizabeth A Shephard
Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1.
The Biochemical journal 2001;355(Pt 1):71-8.
2000: Colin T Dolphin; Azara Janmohamed; RL Smith; Elizabeth A Shephard; Ian R Phillips
Compound heterozygosity for missense mutations in the flavin-containing monooxygenase 3 (FM03) gene in patients with fish-odour syndrome.
Pharmacogenetics 2000;10(9):799-807.
2000: Tamara Vanhaecke; Kai O Lindros; T Oinonen; S Coecke; G DeBast; IR Phillips; Elizabeth A Shephard; A Vercruysse; Vera Rogiers
Effect of ethanol on the expression of hepatic glutathione S-transferase: an in vivo/in vitro study.
Biochemical pharmacology 2000;60(10):1491-6.
2000: Johnathan R Whetstine; Mei-Fei Yueh; D Gail McCarver; David E Williams; C S Park; J H Kang; Young-Nam Cha; Colin T Dolphin; Elizabeth A Shephard; Ian R Phillips; Ronald Hines
Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans.
Toxicology and applied pharmacology 2000;168(3):216-24.
2000: S Coecke; Tamara Vanhaecke; André Foriers; IR Phillips; A Vercruysse; Elizabeth A Shephard; Vera Rogiers
Hormonal regulation of glutathione S-transferase expression in co-cultured adult rat hepatocytes.
The Journal of endocrinology 2000;166(2):363-71.
2000: Helena C Murphy; Colin T Dolphin; Azara Janmohamed; HC Holmes; H Michelakakis; Elizabeth A Shephard; Ronald A Chalmers; Ian R Phillips; Richard A Iles
A novel mutation in the flavin-containing monooxygenase 3 gene, FM03, that causes fish-odour syndrome: activity of the mutant enzyme assessed by proton NMR spectroscopy.
Pharmacogenetics 2000;10(5):439-51.
1998: Colin T Dolphin; D J Beckett; Azara Janmohamed; Timothy E Cullingford; RL Smith; Elizabeth A Shephard; Ian R Phillips
The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein.
The Journal of biological chemistry 1998;273(46):30599-607.
1998: S Coecke; G Debast; IR Phillips; A Vercruysse; Elizabeth A Shephard; Vera Rogiers
Hormonal regulation of microsomal flavin-containing monooxygenase activity by sex steroids and growth hormone in co-cultured adult male rat hepatocytes.
Biochemical pharmacology 1998;56(8):1047-51.
1998: S Coecke; A Callaerts; Ian R Phillips; A Vercruysse; Elizabeth A Shephard; Vera Rogiers
Effect of Thyroid Hormones onFlavin-containing Monooxygenase Activity in Co-cultured Adult Rat Hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 1998;12(4):335-41.
1998: H Dell; Siew-Cheng Wong; I R Phillips; Elizabeth A Shephard
Identification of regulatory protein-binding sites in cytochrome P450 genes by means of the gel-retardation assay.
Methods in molecular biology (Clifton, N.J.) 1998;107():381-94.
1997: Colin T Dolphin; J H Riley; RL Smith; Elizabeth A Shephard; Ian R Phillips
Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA.
Genomics 1997;46(2):260-7.
1997: Colin T Dolphin; Azara Janmohamed; RL Smith; Elizabeth A Shephard; Ian R Phillips
Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome.
Nature genetics 1997;17(4):491-4.
1997: Kerstin Kramer; Elizabeth A Shephard; I R Phillips
Immortalized hepatocytes from transgenic mice.
Biochemical Society transactions 1997;25(1):42S.
1996: R R McCombie; Colin T Dolphin; Sue Povey; Ian R Phillips; Elizabeth A Shephard
Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q.
Genomics 1996;34(3):426-9.
1996: Colin T Dolphin; Timothy E Cullingford; Elizabeth A Shephard; RL Smith; Ian R Phillips
Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04.
European journal of biochemistry / FEBS 1996;235(3):683-9.
1995: Vera Rogiers; B Blaauboer; P Maurel; IR Phillips; Elizabeth A Shephard
Hepatocyte-based in vitro models and their application in pharmacotoxicology Report of an EC DGXII meeting with representatives of the European pharmaceutical industry.
Toxicology in vitro : an international journal published in association with BIBRA 1995;9(5):685-94.
1995: G Debast; S Coecke; M Akrawi; André Foriers; A Vercruysse; IR Phillips; Elizabeth A Shephard; Vera Rogiers
Effect of ethanol on glutathione S-transferase expression in co-cultured rat hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 1995;9(4):467-71.
1995: Vera Rogiers; M Akrawi; A Vercruysse; Ian R Phillips; Elizabeth A Shephard
Effects of the anticonvulsant, valproate, on the expression of components of the cytochrome-P-450-mediated monooxygenase system and glutathione S-transferases.
European journal of biochemistry / FEBS 1995;231(2):337-43.
1995: Ian R Phillips; Colin T Dolphin; P Clair; M R Hadley; Andrew J Hutt; R R McCombie; RL Smith; Elizabeth A Shephard
The molecular biology of the flavin-containing monooxygenases of man.
Chemico-biological interactions 1995;96(1):17-32.
1994: Elizabeth A Shephard; L A Forrest; A Shervington; L M Fernandez; Giuseppe Ciaramella; Ian R Phillips
Interaction of proteins with a cytochrome P450 2B2 gene promoter: identification of two DNA sequences that bind proteins that are enriched or activated in response to phenobarbital.
DNA and cell biology 1994;13(8):793-804.
1994: L A Forrest; A Shervington; Ian R Phillips; Elizabeth A Shephard
Regulation of cytochrome P4502B2 gene expression.
Biochemical Society transactions 1994;22(2):125S.
1994: M Akrawi; Vera Rogiers; A Vercruysse; Ian R Phillips; Elizabeth A Shephard
Long-term preservation and induction of drug metabolizing enzymes in co-cultured rat hepatocytes.
Biochemical Society transactions 1994;22(2):124S.
1994: A P Elia; Elizabeth A Shephard; Ian R Phillips
Regulation of CYP2B gene expression in the intestinal mucosa.
Biochemical Society transactions 1994;22(2):123S.
1994: M Nanji; P Clair; Elizabeth A Shephard; Ian R Phillips
Expression in a baculovirus system of a cDNA encoding human CYP2A6.
Biochemical Society transactions 1994;22(2):122S.
1994: A Shervington; Elizabeth A Shephard; Ian R Phillips
Identification of DNA sequences involved in the transcription of a CYP2B2 gene.
Biochemical Society transactions 1994;22(2):121S.
1994: Giuseppe Ciaramella; M Edwards; Elizabeth A Shephard; Ian R Phillips
Cell systems capable of sustaining phenobarbital induction by CYP2B genes.
Biochemical Society transactions 1994;22(2):120S.
1993: M Akrawi; Elizabeth A Shephard; Ian R Phillips; A Vercruysse; Vera Rogiers
Effects of phenobarbital and valproate on the expression of cytochromes P-450 in co-cultured rat hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 1993;7(4):477-80.
1993: M Akrawi; Vera Rogiers; Y Vandenberghe; C N Palmer; A Vercruysse; Elizabeth A Shephard; Ian R Phillips
Maintenance and induction in co-cultured rat hepatocytes of components of the cytochrome P450-mediated mono-oxygenase.
Biochemical pharmacology 1993;45(8):1583-91.
1993: Elizabeth A Shephard; Colin T Dolphin; M F Fox; Sue Povey; R Smith; Ian R Phillips
Localization of genes encoding three distinct flavin-containing monooxygenases to human chromosome 1q.
Genomics 1993;16(1):85-9.
1992: Colin T Dolphin; Elizabeth A Shephard; Sue Povey; RL Smith; Ian R Phillips
Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family.
The Biochemical journal 1992;287 ( Pt 1)():261-7.
1992: C N Palmer; P J Coates; S E Davies; Elizabeth A Shephard; Ian R Phillips
Localization of cytochrome P-450 gene expression in normal and diseased human liver by in situ hybridization of wax-embedded archival material.
Hepatology (Baltimore, Md.) 1992;16(3):682-7.
1992: Vera Rogiers; A Callaerts; A Vercruysse; M Akrawi; Elizabeth A Shephard; I Phillips
Effects of valproate on xenobiotic biotransformation in rat liver. In vivo and in vitro experiments.
Pharmaceutisch weekblad. Scientific edition 1992;14(3A):127-31.
1992: Elizabeth A Shephard; C N Palmer; H J Segall; Ian R Phillips
Quantification of cytochrome P450 reductase gene expression in human tissues.
Archives of biochemistry and biophysics 1992;294(1):168-72.
1992: Vera Rogiers; M Akrawi; Y Vandenberghe; Elizabeth A Shephard; I Phillips; A Vercruysse
Co-cultures of rat hepatocytes in the study of valproate toxicity.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1992;15():156-9.
1991: Elizabeth A Shephard; Sue Povey; N K Spurr; Ian R Phillips
Chromosomal localization of a cytochrome b5 gene to human chromosome 18 and a cytochrome b5 pseudogene to the X chromosome.
Genomics 1991;11(2):302-8.
1991: Colin T Dolphin; Elizabeth A Shephard; Sue Povey; C N Palmer; D M Ziegler; R Ayesh; RL Smith; Ian R Phillips
Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1).
The Journal of biological chemistry 1991;266(19):12379-85.
1990: C N Palmer; Elizabeth A Shephard; Ian R Phillips
Quantification of cytochrome P-450 gene expression in human tissues.
Biochemical Society transactions 1990;18(4):615-6.
1989: Elizabeth A Shephard; Ian R Phillips; I Santisteban; L F West; C N Palmer; Alan Ashworth; Sue Povey
Isolation of a human cytochrome P-450 reductase cDNA clone and localization of the corresponding gene to chromosome 7q11.2.
Annals of human genetics 1989;53(Pt 4):291-301.
1989: Elizabeth A Shephard; Ian R Phillips; I Santisteban; C N Palmer; Sue Povey
Cloning, expression and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family.
Annals of human genetics 1989;53(Pt 1):23-31.
1988: Peter C Bull; Elizabeth A Shephard; Sue Povey; I Santisteban; Ian R Phillips
Cloning and chromosomal mapping of human cytochrome b5 reductase (DIA1).
Annals of human genetics 1988;52(Pt 4):263-8.
1988: C A Austin; Elizabeth A Shephard; S F Pike; B R Rabin; Ian R Phillips
The effect of terpenoid compounds on cytochrome P-450 levels in rat liver.
Biochemical pharmacology 1988;37(11):2223-9.
1988: I Santisteban; Sue Povey; Elizabeth A Shephard; Ian R Phillips
The major phenobarbital-inducible cytochrome P-450 gene subfamily (P450IIB) mapped to the long arm of human chromosome 19.
Annals of human genetics 1988;52(Pt 2):129-35.
1987: Elizabeth A Shephard; Ian R Phillips; Alan Ashworth; Jane E Ferrie; L A Forrest; D R Bell; S Thompson; C A Austin
Structure and expression of genes coding for components of the cytochrome P-450-mediated mono-oxygenase.
Biochemical Society transactions 1987;15(4):573-5.
1986: M B Davis; L F West; Elizabeth A Shephard; Ian R Phillips
Regional localization of a human cytochrome P-450 (CYP1) to chromosome 19q13.1-13.3.
Annals of human genetics 1986;50(Pt 3):237-40.
1985: Ian R Phillips; Elizabeth A Shephard; Sue Povey; M B Davis; G Kelsey; M Monteiro; L F West; John Kenneth Cowell
A cytochrome P-450 gene family mapped to human chromosome 19.
Annals of human genetics 1985;49(Pt 4):267-74.
1985: S F Pike; Elizabeth A Shephard; B R Rabin; Ian R Phillips
Induction of cytochrome P-450 by phenobarbital is mediated at the level of transcription.
Biochemical pharmacology 1985;34(14):2489-94.
1983: Ian R Phillips; Elizabeth A Shephard; Alan Ashworth; B R Rabin
Cloning and sequence analysis of a rat liver cDNA coding for a phenobarbital-inducible microheterogenous cytochrome P-450 variant: regulation of its messenger level by xenobiotics.
Gene 1983;26(1):41-52.
1983: Ian R Phillips; Elizabeth A Shephard; B R Rabin; R M Bayney; S F Pike; Alan Ashworth; M R Estall
Factors controlling the expression of genes coding for drug-metabolizing enzymes.
Biochemical Society transactions 1983;11(4):460-3.
1983: Elizabeth A Shephard; Ian R Phillips; R M Bayney; S F Pike; B R Rabin
Quantification of NADPH: cytochrome P-450 reductase in liver microsomes by a specific radioimmunoassay technique.
The Biochemical journal 1983;211(2):333-40.
1983: Ian R Phillips; Elizabeth A Shephard; R M Bayney; S F Pike; B R Rabin; R Heath; N Carter
Induction and repression of the major phenobarbital-induced cytochrome P-450 measured by radioimmunoassay.
The Biochemical journal 1983;212(1):55-64.
1983: Elizabeth A Shephard; S F Pike; B R Rabin; Ian R Phillips
A rapid one-step purification of NADPH-cytochrome c (P-450) reductase from rat liver microsomes.
Analytical biochemistry 1983;129(2):430-3.
1982: Elizabeth A Shephard; Ian R Phillips; S F Pike; Alan Ashworth; B R Rabin
Differential effect of phenobarbital and beta-naphthoflavone on the mRNAs coding for cytochrome P450 and NADPH cytochrome P450 reductase.
FEBS letters 1982;150(2):375-80.
1982: F Mitani; Elizabeth A Shephard; Ian R Phillips; B R Rabin
Complexes of cytochrome P450 with metyrapone. A convenient method for the quantitative analysis of phenobarbital-inducible cytochrome P450 in rat liver microsomes.
FEBS letters 1982;148(2):302-6.
1981: Ian R Phillips; Elizabeth A Shephard; F Mitani; B R Rabin
Induction by phenobarbital of the mRNA for a specific variant of rat liver microsomal cytochrome P-450.
The Biochemical journal 1981;196(3):839-51.