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Dawn Shepherd

Research Profile

Chemicals & Drugs

Anatomy

Physiology

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Publications

TOP 3
Anneliese O Speak; Daniëlle te Vruchte; Natacha Veerapen; James E Wraith; Nicole M Yanjanin; Nick Platt; Forbes D Porter; Heiko Runz; Mariolina Salio; Dawn Shepherd; Louise Simmons; David A Smith; Michael Beck; Gurdyal S Besra; Vincenzo Cerundolo; Ralf Hartung; Christian J Hendriksz; Jackie Imrie; Robin H Lachmann; Eugen Mengel; Frances M Platt
Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C.
Bo Pei; Anneliese O Speak; Dawn Shepherd; Terry D Butters; Vincenzo Cerundolo; Frances M Platt; Mitchell Kronenberg
Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids.
Ji-Li Chen; Anthony J Morgan; Guillaume Stewart-Jones; Dawn Shepherd; Giovanna Bossi; Linda Wooldridge; Sarah L Hutchinson; Andrew K Sewell; Gillian M Griffiths; Philip van der Merwe; E Yvonne Jones; Antony Galione; Vincenzo Cerundolo
Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.

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All Publications

2012: Anneliese O Speak; Daniëlle te Vruchte; Natacha Veerapen; James E Wraith; Nicole M Yanjanin; Nick Platt; Forbes D Porter; Heiko Runz; Mariolina Salio; Dawn Shepherd; Louise Simmons; David A Smith; Michael Beck; Gurdyal S Besra; Vincenzo Cerundolo; Ralf Hartung; Christian J Hendriksz; Jackie Imrie; Robin H Lachmann; Eugen Mengel; Frances M Platt
Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C.
European journal of immunology 2012;42(7):1886-92.
2011: Bo Pei; Anneliese O Speak; Dawn Shepherd; Terry D Butters; Vincenzo Cerundolo; Frances M Platt; Mitchell Kronenberg
Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(3):1348-60.
2010: Ji-Li Chen; Anthony J Morgan; Guillaume Stewart-Jones; Dawn Shepherd; Giovanna Bossi; Linda Wooldridge; Sarah L Hutchinson; Andrew K Sewell; Gillian M Griffiths; Philip van der Merwe; E Yvonne Jones; Antony Galione; Vincenzo Cerundolo
Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(4):1829-39.
2009: Gijs I van Boxel; Guillaume Stewart-Jones; Samantha Holmes; Sarah Sainsbury; Dawn Shepherd; G M A Gillespie; Karl Harlos; David I Stuart; Ray Owens; E Yvonne Jones
Some lessons from the systematic production and structural analysis of soluble (alpha)(beta) T-cell receptors.
Journal of immunological methods 2009;350(1-2):14-21.
2009: Gopal R Bommineni; Jonathan Silk; Mariolina Salio; Rengarajan Balamurugan; Dawn Shepherd; Gerd Ritter; Vincenzo Cerundolo; Richard R Schmidt
Nonglycosidic agonists of invariant NKT cells for use as vaccine adjuvants.
ChemMedChem 2009;4(2):171-5.
2008: Jonathan Silk; Mariolina Salio; Gopal R Bommineni; Dawn Shepherd; Uzi Gileadi; James Brown; S Hajar Masri; Paolo Polzella; Gerd Ritter; Gurdyal S Besra; E Yvonne Jones; Richard R Schmidt; Vincenzo Cerundolo
Cutting edge: nonglycosidic CD1d lipid ligands activate human and murine invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6452-6.
2008: Galit Denkberg; Victoria S Stronge; Efrat Zahavi; Paola Pittoni; Ravit Oren; Dawn Shepherd; Mariolina Salio; Corinna McCarthy; Petr A Illarionov; Philip van der Merwe; Gurdyal S Besra; Paolo Dellabona; Giulia Casorati; Vincenzo Cerundolo; Yoram Reiter
Phage display-derived recombinant antibodies with TCR-like specificity against alpha-galactosylceramide and its analogues in complex with human CD1d molecules.
European journal of immunology 2008;38(3):829-40.
2007: Mariolina Salio; Anneliese O Speak; Dawn Shepherd; Paolo Polzella; Petr A Illarionov; Natacha Veerapen; Gurdyal S Besra; Frances M Platt; Vincenzo Cerundolo
Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(51):20490-5.
2007: Corinna McCarthy; Dawn Shepherd; Sebastian Fleire; Victoria S Stronge; Michael Koch; Petr A Illarionov; Giovanna Bossi; Mariolina Salio; Galit Denkberg; Faye Reddington; Andrea Tarlton; Gopal R Bommineni; Richard R Schmidt; Yoram Reiter; Gillian M Griffiths; Philip van der Merwe; Gurdyal S Besra; E Yvonne Jones; Facundo D Batista; Vincenzo Cerundolo
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation.
The Journal of experimental medicine 2007;204(5):1131-44.
2007: Ian F Hermans; Jonathan Silk; Uzi Gileadi; S Hajar Masri; Dawn Shepherd; Kathryn J Farrand; Mariolina Salio; Vincenzo Cerundolo
Dendritic cell function can be modulated through cooperative actions of TLR ligands and invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2721-9.
2006: Isabel Quiroga; Mariolina Salio; Dicken D H Koo; Lucia Cerundolo; Dawn Shepherd; Vincenzo Cerundolo; Susan V Fuggle
Expression of MHC class I-related Chain B (MICB) molecules on renal transplant biopsies.
Transplantation 2006;81(8):1196-203.
2006: Stephan D Gadola; Michael Koch; Jon Marles-Wright; Nikolai M Lissin; Dawn Shepherd; Gediminas Matulis; Karl Harlos; Peter M Villiger; David I Stuart; Bent K Jakobsen; Vincenzo Cerundolo; E Yvonne Jones
Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors.
The Journal of experimental medicine 2006;203(3):699-710.
2005: Michael Koch; Victoria S Stronge; Dawn Shepherd; Stephan D Gadola; Bini Mathew; Gerd Ritter; Alan Fersht; Gurdyal S Besra; Richard R Schmidt; E Yvonne Jones; Vincenzo Cerundolo
The crystal structure of human CD1d with and without alpha-galactosylceramide.
Nature immunology 2005;6(8):819-26.
2005: Caroline L Smith; P Rod Dunbar; Mirza Fareed; Michael J Palmowski; Dawn Shepherd; Sarah Gilbert; Pierre Coulie; Joerg Schneider; Eric Hoffman; Robert Hawkins; Adrian L Harris; Vincenzo Cerundolo
Recombinant modified vaccinia Ankara primes functionally activated CTL specific for a melanoma tumor antigen epitope in melanoma patients with a high risk of disease recurrence.
International journal of cancer. Journal international du cancer 2005;113(2):259-66.
2004: Jonathan Silk; Ian F Hermans; Uzi Gileadi; Tsung Wen Chong; Dawn Shepherd; Mariolina Salio; Bini Mathew; Richard R Schmidt; Sarah Jane Lunt; Kaye J Williams; Ian J Stratford; Adrian L Harris; Vincenzo Cerundolo
Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy.
The Journal of clinical investigation 2004;114(12):1800-11.
2004: Thil Batuwangala; Dawn Shepherd; Stephan D Gadola; Kevin J C Gibson; Nathan R Zaccai; Alan Fersht; Gurdyal S Besra; Vincenzo Cerundolo; E Yvonne Jones
The crystal structure of human CD1b with a bound bacterial glycolipid.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2382-8.
2004: Laura Papagno; Celsa A Spina; Arnaud Marchant; Mariolina Salio; Nathalie Rufer; Susan Little; Tao Dong; Gillian Chesney; Anele Waters; Philippa Easterbrook; P Rod Dunbar; Dawn Shepherd; Vincenzo Cerundolo; Vincent Emery; Paul Griffiths; Christopher Conlon; Andrew J McMichael; Douglas D Richman; Sarah L Rowland-Jones; Victor Appay
Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection.
PLoS biology 2004;2(2):E20.
2003: Stephan D Gadola; Anastasios Karadimitris; Nathan R Zaccai; Mariolina Salio; Nicolas Dulphy; Dawn Shepherd; E Yvonne Jones; Vincenzo Cerundolo
Generation of CD1 tetramers as a tool to monitor glycolipid-specific T cells.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2003;358(1433):875-7.
2003: Mariolina Salio; Marina Cella; William Vermi; Fabio Facchetti; Michael J Palmowski; Caroline L Smith; Dawn Shepherd; Marco COLONna; Vincenzo Cerundolo
Plasmacytoid dendritic cells prime IFN-gamma-secreting melanoma-specific CD8 lymphocytes and are found in primary melanoma lesions.
European journal of immunology 2003;33(4):1052-62.
2002: Stephan D Gadola; Nathan R Zaccai; Karl Harlos; Dawn Shepherd; Julio C Castro-Palomino; Gerd Ritter; Richard R Schmidt; E Yvonne Jones; Vincenzo Cerundolo
Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains.
Nature immunology 2002;3(8):721-6.
2001: Mariolina Salio; Dawn Shepherd; P Rod Dunbar; Michael J Palmowski; K Murphy; L Wu; Vincenzo Cerundolo
Mature dendritic cells prime functionally superior melan-A-specific CD8+ lymphocytes as compared with nonprofessional APC.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1188-97.
2000: P Rod Dunbar; Caroline L Smith; D Chao; Mariolina Salio; Dawn Shepherd; Mirza Fareed; Martin Lipp; Antonio Lanzavecchia; F Sallusto; A Evans; R Russell-Jones; Adrian L Harris; Vincenzo Cerundolo
A shift in the phenotype of melan-A-specific CTL identifies melanoma patients with an active tumor-specific immune response.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6644-52.