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Peter Shepherd

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Emmanuelle Cognard; Coralie G Dargaville; Deborah L Hay; Peter R Shepherd
Identification of a pathway by which glucose regulates β-catenin signalling via the cAMP/protein kinase A pathway in β-cell models.
Jonas Benzler; Goutham K Ganjam; DR Grattan; Christiane E Koch; Manon Krüger; Maria Kutschke; Olaf Pinkenburg; Michael W Schwartz; Peter R Shepherd; Juliane Steger; Sigrid Stöhr; Rebecca Ölkrug; Alexander Tups
Hypothalamic glycogen synthase kinase 3β has a central role in the regulation of food intake and glucose metabolism.
Peter R Shepherd; William A Denny
Beta-testing of PI3-kinase inhibitors: is beta better?

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All Publications

2013: Emmanuelle Cognard; Coralie G Dargaville; Deborah L Hay; Peter R Shepherd
Identification of a pathway by which glucose regulates β-catenin signalling via the cAMP/protein kinase A pathway in β-cell models.
The Biochemical journal 2013;449(3):803-11.
2012: Jonas Benzler; Goutham K Ganjam; DR Grattan; Christiane E Koch; Manon Krüger; Maria Kutschke; Olaf Pinkenburg; Michael W Schwartz; Peter R Shepherd; Juliane Steger; Sigrid Stöhr; Rebecca Ölkrug; Alexander Tups
Hypothalamic glycogen synthase kinase 3β has a central role in the regulation of food intake and glucose metabolism.
The Biochemical journal 2012;447(1):175-84.
2012: Peter R Shepherd; William A Denny
Beta-testing of PI3-kinase inhibitors: is beta better?
Cancer discovery 2012;2(5):393-4.
2012: Christina M Buchanan; Philip S Crosier; Jack U Flanagan; Gordon W Rewcastle; Jonathan W Astin; Jen-Hsing Shih; Peter R Shepherd
DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular.
Clinical science (London, England : 1979) 2012;122(10):449-57.
2012: Ji Eun Kim; Euphemia Leung; Wayne A Phillips; Andrew N Shelling; Peter R Shepherd; Clare Stones; Graeme J Finlay; Wayne R Joseph; Bruce C Baguley
Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines.
BMC cancer 2012;12():141.
2011: Gordon W Rewcastle; Ripudaman Singh; Bruce C Baguley; Christina M Buchanan; William A Denny; Jack U Flanagan; Raphael Frederick; Swarna A Gamage; Stephen M F Jamieson; Jackie D Kendall; Philip Kestell; Sharada Kolekar; Woo-Jeong Lee; Claire L Lill; Elaine S Marshall; Peter R Shepherd
Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).
Journal of medicinal chemistry 2011;54(20):7105-26.
2011: Stephen Jamieson; Jackie D Kendall; Sharada Kolekar; Woo-Jeong Lee; Gordon W Rewcastle; Bruce C Baguley; Christina Buchanan; William A Denny; James Dickson; Jack U Flanagan; Ripudaman Singh; Peter R Shepherd
A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types.
The Biochemical journal 2011;438(1):53-62.
2011: Jessica L Costa; Greg Smith; Maureen Watson; Jian-Ming Lin; Karen Callon; Greg Gamble; Anthony Cheng; Mark H Vickers; Peter R Shepherd; Jillian Cornish; Andrew Grey
The atypical anti-psychotic clozapine decreases bone mass in rats in vivo.
Schizophrenia research 2011;126(1-3):291-7.
2010: Christiane Koch; Rachael A Augustine; Juliane Steger; Goutham K Ganjam; Jonas Benzler; Corinna Pracht; Chrishanthi Lowe; Michael W Schwartz; Peter R Shepherd; Greg M Anderson; DR Grattan; Alexander Tups
Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(48):16180-7.
2010: A J Kolnes; A Ingvaldsen; A Bolling; J T Stuenaes; M Kreft; Robert Zorec; Peter R Shepherd; Jørgen Jensen
Caffeine and theophylline block insulin-stimulated glucose uptake and PKB phosphorylation in rat skeletal muscles.
Acta physiologica (Oxford, England) 2010;200(1):65-74.
2010: Andrew Grey; Claire Chaussade; Victoria Empson; Jian-Ming Lin; Maureen Watson; Susannah O'Sullivan; Gordon Rewcastle; Dorit Naot; Jillian Cornish; Peter R Shepherd
Evidence for a role for the p110-alpha isoform of PI3K in skeletal function.
Biochemical and biophysical research communications 2010;391(1):564-9.
2009: Greg C Smith; Mark H Vickers; Emmanuelle Cognard; Peter R Shepherd
Clozapine and quetiapine acutely reduce glucagon-like peptide-1 production and increase glucagon release in obese rats: implications for glucose metabolism and food choice behaviour.
Schizophrenia research 2009;115(1):30-40.
2009: Raphaël Frédérick; Claire Mawson; Jackie D Kendall; Claire Chaussade; Gordon W Rewcastle; Peter R Shepherd; William A Denny
Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening.
Bioorganic & medicinal chemistry letters 2009;19(20):5842-7.
2009: Claire Chaussade; Kitty Cho; Claire Mawson; Gordon W Rewcastle; Peter R Shepherd
Functional differences between two classes of oncogenic mutation in the PIK3CA gene.
Biochemical and biophysical research communications 2009;381(4):577-81.
2009: Ji Eun Kim; Peter R Shepherd; Claire Chaussade
Investigating the role of class-IA PI 3-kinase isoforms in adipocyte differentiation.
Biochemical and biophysical research communications 2009;379(4):830-4.
2008: G C Smith; C Chaussade; Mark Vickers; J Jensen; Peter R Shepherd
Atypical antipsychotic drugs induce derangements in glucose homeostasis by acutely increasing glucagon secretion and hepatic glucose output in the rat.
Diabetologia 2008;51(12):2309-17.
2008: Sasha H Anagnostou; Peter R Shepherd
Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines.
The Biochemical journal 2008;416(2):211-8.
2008: Jørgen Jensen; Line M Grønning-Wang; Einar Jebens; Jonathan P Whitehead; Robert Zorec; Peter R Shepherd
Adrenaline potentiates insulin-stimulated PKB activation in the rat fast-twitch epitrochlearis muscle without affecting IRS-1-associated PI 3-kinase activity.
Pflügers Archiv : European journal of physiology 2008;456(5):969-78.
2007: Jackie D Kendall; Gordon W Rewcastle; Raphael Frederick; Claire Mawson; William A Denny; Elaine S Marshall; Bruce C Baguley; Claire Chaussade; Shaun P Jackson; Peter R Shepherd
Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors.
Bioorganic & medicinal chemistry 2007;15(24):7677-87.
2007: Claire Chaussade; Gordon W Rewcastle; Jackie D Kendall; William A Denny; Kitty Cho; Line M Grønning; Mei Ling Chong; Sasha H Anagnostou; Shaun P Jackson; Nathalie Daniele; Peter R Shepherd
Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.
The Biochemical journal 2007;404(3):449-58.
2007: Jørgen Jensen; Erlend O Brennesvik; Yu-Chiang Lai; Peter R Shepherd
GSK-3beta regulation in skeletal muscles by adrenaline and insulin: evidence that PKA and PKB regulate different pools of GSK-3.
Cellular signalling 2007;19(1):204-10.
2006: Line M Grønning; Rommaneeya Tingsabadh; Kristine Hardy; Knut Thomas Dalen; Parmjit S Jat; Luigi Gnudi; Peter R Shepherd
Glucose induces increases in levels of the transcriptional repressor Id2 via the hexosamine pathway.
American journal of physiology. Endocrinology and metabolism 2006;290(4):E599-606.
2005: Erlend O Brennesvik; Chariklia Ktori; Jérôme Ruzzin; Einar Jebens; Peter R Shepherd; Jørgen Jensen
Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline.
Cellular signalling 2005;17(12):1551-9.
2005: Shaun P Jackson; Simone M Schoenwaelder; Isaac Goncalves; Warwick S Nesbitt; Cindy L Yap; Christine E Wright; Vijaya Kenche; Karen E Anderson; Sacha M Dopheide; Yuping Yuan; Sharelle A Sturgeon; Hishani Prabaharan; Philip E Thompson; Gregg D Smith; Peter R Shepherd; Nathalie Daniele; Suhasini Kulkarni; Belinda M Abbott; Dilek Saylik; Catherine Jones; Lucy Lu; Simon Giuliano; Sascha C Hughan; James A Angus; Alan D Robertson; Hatem H Salem
PI 3-kinase p110beta: a new target for antithrombotic therapy.
Nature medicine 2005;11(5):507-14.
2004: Li Li; Line M Grønning; Per O Anderson; Suling Li; Klaus Edvardsen; Jim Johnston; Dimitris Kioussis; Peter R Shepherd; Ping Wang
Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism.
The Journal of biological chemistry 2004;279(33):34107-14.
2004: Lazaros C Foukas; Peter R Shepherd
eIF4E binding protein 1 and H-Ras are novel substrates for the protein kinase activity of class-I phosphoinositide 3-kinase.
Biochemical and biophysical research communications 2004;319(2):541-9.
2004: Susan W Y Cheng; Lee G D Fryer; David Carling; Peter R Shepherd
Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status.
The Journal of biological chemistry 2004;279(16):15719-22.
2004: Lazaros C Foukas; Peter R Shepherd
Phosphoinositide 3-kinase: the protein kinase that time forgot.
Biochemical Society transactions 2004;32(Pt 2):330-1.
2004: Carles Cantó; Elisabeth Suárez; Jose Lizcano; Elisenda Griñó; Peter R Shepherd; Lee G D Fryer; David Carling; Joan Bertran; Manuel Palacín; Antonio Zorzano; Anna Gumà
Neuregulin signaling on glucose transport in muscle cells.
The Journal of biological chemistry 2004;279(13):12260-8.
2004: Lazaros C Foukas; George Panayotou; Peter R Shepherd
Direct interaction of major histocompatibility complex class II-derived peptides with class Ia phosphoinositide 3-kinase results in dose-dependent stimulatory effects.
The Journal of biological chemistry 2004;279(9):7505-11.
2004: Lazaros C Foukas; Caroline A Beeton; Jorgen Jensen; Wayne A Phillips; Peter R Shepherd
Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo.
Molecular and cellular biology 2004;24(3):966-75.
2004: Peter R Shepherd
Secrets of insulin and IGF-1 regulation of insulin secretion revealed.
The Biochemical journal 2004;377(Pt 1):e1-2.
2003: Carolyn Horrocks; Reza Halse; Rami Suzuki; Peter R Shepherd
Human cell systems for drug discovery.
Current opinion in drug discovery & development 2003;6(4):570-5.
2003: Chariklia Ktori; Peter R Shepherd; Lisa O'Rourke
TNF-alpha and leptin activate the alpha-isoform of class II phosphoinositide 3-kinase.
Biochemical and biophysical research communications 2003;306(1):139-43.
2002: Lisa O'Rourke; Line M Gronning; Stephen J Yeaman; Peter R Shepherd
Glucose-dependent regulation of cholesterol ester metabolism in macrophages by insulin and leptin.
The Journal of biological chemistry 2002;277(45):42557-62.
2002: Lazaros C Foukas; Nathalie Daniele; Chariklia Ktori; Karen E Anderson; Jorgen Jensen; Peter R Shepherd
Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.
The Journal of biological chemistry 2002;277(40):37124-30.
2002: Nathalie Daniele; Reza Halse; E Grinyo; Stephen J Yeaman; Peter R Shepherd
Conditionally immortalized cell lines as model systems for high-throughput biology in drug discovery.
Biochemical Society transactions 2002;30(4):800-2.
2002: Lisa O'Rourke; Peter R Shepherd
Biphasic regulation of extracellular-signal-regulated protein kinase by leptin in macrophages: role in regulating STAT3 Ser727 phosphorylation and DNA binding.
The Biochemical journal 2002;364(Pt 3):875-9.
2001: Maria A Soos; J Jensen; R A Brown; Stephen O'Rahilly; Peter R Shepherd; Jonathan P Whitehead
Class II phosphoinositide 3-kinase is activated by insulin but not by contraction in skeletal muscle.
Archives of biochemistry and biophysics 2001;396(2):244-8.
2001: R A Brown; Peter R Shepherd
Growth factor regulation of the novel class II phosphoinositide 3-kinases.
Biochemical Society transactions 2001;29(Pt 4):535-7.
2001: Lisa O'Rourke; Stephen J Yeaman; Peter R Shepherd
Insulin and leptin acutely regulate cholesterol ester metabolism in macrophages by novel signaling pathways.
Diabetes 2001;50(5):955-61.
2000: Caroline A Beeton; E M Chance; Lazaros C Foukas; Peter R Shepherd
Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110alpha and p110beta catalytic subunits of class-Ia phosphoinositide 3-kinases.
The Biochemical journal 2000;350 Pt 2():353-9.
2000: KC Baynes; Caroline A Beeton; George Panayotou; R Stein; Maria A Soos; T Hansen; H Simpson; Stephen O'Rahilly; Peter R Shepherd; Jonathan P Whitehead
Natural variants of human p85 alpha phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity.
Diabetologia 2000;43(3):321-31.
1999: BT Navé; M Ouwens; DJ Withers; D R Alessi; Peter R Shepherd
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
The Biochemical journal 1999;344 Pt 2():427-31.
1999: Peter R Shepherd; Barbara B Kahn
Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus.
The New England journal of medicine 1999;341(4):248-57.
1999: R A Brown; J Domin; Alexandre Arcaro; Michael D Waterfield; Peter R Shepherd
Insulin activates the alpha isoform of class II phosphoinositide 3-kinase.
The Journal of biological chemistry 1999;274(21):14529-32.
1999: Caroline A Beeton; P Das; M D Waterfield; Peter R Shepherd
The SH3 and BH domains of the p85alpha adapter subunit play a critical role in regulating class Ia phosphoinositide 3-kinase function.
Molecular cell biology research communications : MCBRC 1999;1(2):153-7.
1998: Peter R Shepherd; DJ Withers; Kenneth Siddle
Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling.
The Biochemical journal 1998;333 ( Pt 3)():471-90.
1998: Perla Kaliman; Judith Canicio; Peter R Shepherd; Caroline A Beeton; Xavier Testar; Manuel Palacín; Antonio Zorzano
Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells.
Molecular endocrinology (Baltimore, Md.) 1998;12(1):66-77.
1997: DJ Withers; D Margriet Ouwens; BT Nave; Gerard C M van der Zon; C M Alarcon; Maria E Cardenas; J Heitman; J Antonie Maassen; Peter R Shepherd
Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells.
Biochemical and biophysical research communications 1997;241(3):704-9.
1997: Peter R Shepherd; BT Nave; J Rincon; R J Haigh; E Foulstone; C Proud; Juleen R Zierath; Kenneth Siddle; Harriet Wallberg-Henriksson
Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism.
Diabetologia 1997;40(10):1172-7.
1997: Peter R Shepherd; Kenneth Siddle; BT Navé
Is stimulation of class-1 phosphatidylinositol 3-kinase activity by insulin sufficient to activate pathways involved in glucose metabolism.
Biochemical Society transactions 1997;25(3):978-81.
1997: Peter R Shepherd; BT Navé; J Rincon; LA Nolte; Anna Bevan; Kenneth Siddle; Juleen R Zierath; Harriet Wallberg-Henriksson
Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle.
The Journal of biological chemistry 1997;272(30):19000-7.
1997: Peter R Shepherd; N J Crowther; M Desai; C Nicholas Hales; Susan E Ozanne
Altered adipocyte properties in the offspring of protein malnourished rats.
The British journal of nutrition 1997;78(1):121-9.
1997: Susan E Ozanne; BT Nave; CL Wang; Peter R Shepherd; J Prins; GD Smith
Poor fetal nutrition causes long-term changes in expression of insulin signaling components in adipocytes.
The American journal of physiology 1997;273(1 Pt 1):E46-51.
1996: Peter R Shepherd; BT Navé; S O'Rahilly
The role of phosphoinositide 3-kinase in insulin signalling.
Journal of molecular endocrinology 1996;17(3):175-84.
1996: BT Navé; Kenneth Siddle; Peter R Shepherd
Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport.
The Biochemical journal 1996;318 ( Pt 1)():203-5.
1996: BT Navé; R J Haigh; A C Hayward; Kenneth Siddle; Peter R Shepherd
Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes.
The Biochemical journal 1996;318 ( Pt 1)():55-60.
1996: Peter R Shepherd; B J Reaves; H W Davidson
Phosphoinositide 3-kinases and membrane traffic.
Trends in cell biology 1996;6(3):92-7.
1996: Luigi Gnudi; Peter R Shepherd; Barbara B Kahn
Over-expression of GLUT4 selectively in adipose tissue in transgenic mice: implications for nutrient partitioning.
The Proceedings of the Nutrition Society 1996;55(1B):191-9.
1995: Juleen R Zierath; L A Nolte; E Wahlström; Dana Galuska; Peter R Shepherd; Barbara B Kahn; Harriet Wallberg-Henriksson
Carrier-mediated fructose uptake significantly contributes to carbohydrate metabolism in human skeletal muscle.
The Biochemical journal 1995;311 ( Pt 2)():517-21.
1995: Peter R Shepherd; Maria A Soos; Kenneth Siddle
Inhibitors of phosphoinositide 3-kinase block exocytosis but not endocytosis of transferrin receptors in 3T3-L1 adipocytes.
Biochemical and biophysical research communications 1995;211(2):535-9.
1995: E Tozzo; Peter R Shepherd; Luigi Gnudi; Barbara B Kahn
Transgenic GLUT-4 overexpression in fat enhances glucose metabolism: preferential effect on fatty acid synthesis.
The American journal of physiology 1995;268(5 Pt 1):E956-64.
1995: Peter R Shepherd; BT Navé; Kenneth Siddle
Insulin activates glycogen synthase by a novel PI 3-kinase/p70s6k dependent pathway in 3T3-L1 adipocytes.
Biochemical Society transactions 1995;23(2):202S.
1995: Peter R Shepherd; BT Navé; Kenneth Siddle
Involvement of PI 3-kinase in stimulation of glucose transport and recruitment of transferrin receptors in 3T3-L1 adipocytes.
Biochemical Society transactions 1995;23(2):201S.
1995: BT Navé; Peter R Shepherd; Kenneth Siddle
Effect of phorbol esters on phosphatidylinositol 3-kinase activity in adipocytes.
Biochemical Society transactions 1995;23(2):183S.
1995: R J Haigh; Peter R Shepherd; BT Navé; Kenneth Siddle
The role of phosphatidylinositol 3-kinase activity in insulin-stimulated mitogenesis in 3T3-L1 adipocytes.
Biochemical Society transactions 1995;23(2):179S.
1995: Luigi Gnudi; E Tozzo; Peter R Shepherd; J L Bliss; Barbara B Kahn
High level overexpression of glucose transporter-4 driven by an adipose-specific promoter is maintained in transgenic mice on a high fat diet, but does not prevent impaired glucose tolerance.
Endocrinology 1995;136(3):995-1002.
1995: Peter R Shepherd; BT Navé; Kenneth Siddle
Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase.
The Biochemical journal 1995;305 ( Pt 1)():25-8.
1993: Peter R Shepherd; Luigi Gnudi; E Tozzo; H Yang; F Leach; Barbara B Kahn
Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.
The Journal of biological chemistry 1993;268(30):22243-6.
1992: Peter R Shepherd; G W Gould; C A Colville; S C McCoid; E Michael Gibbs; Barbara B Kahn
Distribution of GLUT3 glucose transporter protein in human tissues.
Biochemical and biophysical research communications 1992;188(1):149-54.
1992: Peter R Shepherd; E Michael Gibbs; C Wesslau; G W Gould; Barbara B Kahn
Human small intestine facilitative fructose/glucose transporter (GLUT5) is also present in insulin-responsive tissues and brain. Investigation of biochemical characteristics and translocation.
Diabetes 1992;41(10):1360-5.
1992: G W Gould; A M Brant; B B Kahn; Peter R Shepherd; S C McCoid; E Michael Gibbs
Expression of the brain-type glucose transporter is restricted to brain and neuronal cells in mice.
Diabetologia 1992;35(4):304-9.