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Brad Sherborne

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Robert Urich; Grant Wishart; Paul G Wyatt; Michael Kiczun; Daniel Rauh; André Richters; Brad Sherborne; Naomi Tidten-Luksch; Ruth Brenk
De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.
Tomomi Kosugi; Joelle Le; Hiroaki Makino; Yohei Matsueda; Dale R Mitchell; Yasuhiro Oue; Gita Patel; Yuri Sakai; Brad Sherborne; Donald J Simpson; Satoshi Sugiura; Naotaka Suzuki; Osami Takenouchi; Midori Takimoto-Kamimura; Peter S Thomas; Gen Unoki; Yuko Yamakoshi; Vicky Cunliffe; Julie Frearson; Aiko Fujino; Richard Gordon; C John Harris; Minoru Imai; Keiichiro Imaizumi; Heidi Kalloo-Hosein; Mika Kambe; Shinji Kobayashi; Kanji Komatsu; Ken-ichiro Kataoka
Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.
Peter Ray; Jane Wright; Julia Adam; Sylviane Boucharens; Darcey Black; Angus R Brown; Ola Epemolu; Dan Fletcher; Margaret Huggett; Phil Jones; Steven Laats; Amanda Lyons; Jos de Man; Richard Morphy; Brad Sherborne; Lorcan Sherry; Nicole van Straten; Paul Westwood; Mark York
Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.

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All Publications

2013: Robert Urich; Grant Wishart; Paul G Wyatt; Michael Kiczun; Daniel Rauh; André Richters; Brad Sherborne; Naomi Tidten-Luksch; Ruth Brenk
De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.
ACS chemical biology 2013;8(5):1044-52.
2012: Tomomi Kosugi; Joelle Le; Hiroaki Makino; Yohei Matsueda; Dale R Mitchell; Yasuhiro Oue; Gita Patel; Yuri Sakai; Brad Sherborne; Donald J Simpson; Satoshi Sugiura; Naotaka Suzuki; Osami Takenouchi; Midori Takimoto-Kamimura; Peter S Thomas; Gen Unoki; Yuko Yamakoshi; Vicky Cunliffe; Julie Frearson; Aiko Fujino; Richard Gordon; C John Harris; Minoru Imai; Keiichiro Imaizumi; Heidi Kalloo-Hosein; Mika Kambe; Shinji Kobayashi; Kanji Komatsu; Ken-ichiro Kataoka
Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.
Journal of medicinal chemistry 2012;55(15):6700-15.
2011: Peter Ray; Jane Wright; Julia Adam; Sylviane Boucharens; Darcey Black; Angus R Brown; Ola Epemolu; Dan Fletcher; Margaret Huggett; Phil Jones; Steven Laats; Amanda Lyons; Jos de Man; Richard Morphy; Brad Sherborne; Lorcan Sherry; Nicole van Straten; Paul Westwood; Mark York
Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(4):1084-8.
2011: Peter Ray; Jane Wright; Julia Adam; Johnathan Bennett; Sylviane Boucharens; Darcey Black; Andrew Cook; Angus R Brown; Ola Epemolu; Dan Fletcher; Anders Haunso; Margaret Huggett; Phil Jones; Steven Laats; Amanda Lyons; Jordi Mestres; Jos de Man; Richard Morphy; Zoran Rankovic; Brad Sherborne; Lorcan Sherry; Nicole van Straten; Paul Westwood; Guido Z R Zaman
Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(1):97-101.
2003: Yuan H Zhao; Michael H Abraham; Joelle Le; Anne Hersey; Chris N Luscombe; Gordon Beck; Brad Sherborne; Ian Cooper
Evaluation of rat intestinal absorption data and correlation with human intestinal absorption.
European journal of medicinal chemistry 2003;38(3):233-43.
2002: Yuan H Zhao; Michael H Abraham; Joelle Le; Anne Hersey; Chris N Luscombe; Gordon Beck; Brad Sherborne; Ian Cooper
Rate-limited steps of human oral absorption and QSAR studies.
Pharmaceutical research 2002;19(10):1446-57.
2002: Michael H Abraham; Yuan H Zhao; Joelle Le; Anne Hersey; Chris N Luscombe; Derek P Reynolds; Gordon Beck; Brad Sherborne; Ian Cooper
On the mechanism of human intestinal absorption.
European journal of medicinal chemistry 2002;37(7):595-605.
2001: Yuan H Zhao; Joelle Le; Michael H Abraham; Anne Hersey; P J Eddershaw; Chris N Luscombe; D Butina; Gordon Beck; Brad Sherborne; Ian Cooper; James A Platts; D Boutina
Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors.
Journal of pharmaceutical sciences 2001;90(6):749-84.