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Arjen Blom

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D F G Remst; J M Snabel; R Stoop; Wim B van den Berg; R A Bank; Esmeralda N Blaney Davidson; Arjen B Blom; Elly L Vitters; Peter van der Kraan
Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression.
P L E M van Lent; Thomas Vogl; Arjen B Blom; Hans Cats; Floris P J G Lafeber; Willem F Lems; Johannes Roth; Rik F P Schelbergen; Annet W Slöetjes; Wim B van den Berg
Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis.
Rik F P Schelbergen; B Wim Schreurs; Annet W Slöetjes; Wim B van den Berg; Martijn H J van den Bosch; Shahla Abdollahi-Roodsaz; Arjen B Blom; John S Mort; Johannes Roth; Thomas Vogl; P L E M van Lent
Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4.

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All Publications

2013: D F G Remst; J M Snabel; R Stoop; Wim B van den Berg; R A Bank; Esmeralda N Blaney Davidson; Arjen B Blom; Elly L Vitters; Peter van der Kraan
Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2013;21(1):157-64.
2012: P L E M van Lent; Thomas Vogl; Arjen B Blom; Hans Cats; Floris P J G Lafeber; Willem F Lems; Johannes Roth; Rik F P Schelbergen; Annet W Slöetjes; Wim B van den Berg
Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis.
Arthritis and rheumatism 2012;64(5):1466-76.
2012: Rik F P Schelbergen; B Wim Schreurs; Annet W Slöetjes; Wim B van den Berg; Martijn H J van den Bosch; Shahla Abdollahi-Roodsaz; Arjen B Blom; John S Mort; Johannes Roth; Thomas Vogl; P L E M van Lent
Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4.
Arthritis and rheumatism 2012;64(5):1477-87.
2010: Arjen B Blom; P L E M van Lent; Peter van der Kraan; Wim B van den Berg
To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapy.
Current drug targets 2010;11(5):620-9.
2009: P L E M van Lent; W Hofkens; Arjen B Blom; L Grevers; Annet Sloetjes; N Takahashi; L J van Tits; T Vogl; Johannes Roth; M P de Winther; Wim B van den Berg
Scavenger receptor class A type I/II determines matrix metalloproteinase-mediated cartilage destruction and chondrocyte death in antigen-induced arthritis.
Arthritis and rheumatism 2009;60(10):2954-65.
2009: Esmeralda N Blaney Davidson; Dennis F G Remst; Elly L Vitters; Henk M van Beuningen; Arjen B Blom; Marie-Jose Goumans; Wim B van den Berg; Peter van der Kraan
Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7937-45.
2009: Arjen B Blom; Sarah M Brockbank; P L E M van Lent; Henk M van Beuningen; Jeroen Geurts; Nozomi Takahashi; Peter van der Kraan; Fons A J van de Loo; B Willem Schreurs; Kristen Clements; Peter Newham; Wim B van den Berg
Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1.
Arthritis and rheumatism 2009;60(2):501-12.
2008: P L E M van Lent; L C Grevers; Arjen B Blom; Onno J Arntz; Fons A J van de Loo; Peter van der Kraan; Shahla Abdollahi-Roodsaz; G Srikrishna; H Freeze; Annet Sloetjes; W Nacken; T Vogl; Johannes Roth; Wim B van den Berg
Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis.
Arthritis and rheumatism 2008;58(12):3776-87.
2008: P L E M van Lent; L Grevers; Arjen B Blom; Annet Sloetjes; J S Mort; T Vogl; W Nacken; Wim B van den Berg; Johannes Roth
Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis.
Annals of the rheumatic diseases 2008;67(12):1750-8.
2007: P L E M van Lent; Arjen B Blom; L Grevers; Annet Sloetjes; Wim B van den Berg
Toll-like receptor 4 induced FcgammaR expression potentiates early onset of joint inflammation and cartilage destruction during immune complex arthritis: Toll-like receptor 4 largely regulates FcgammaR expression by interleukin 10.
Annals of the rheumatic diseases 2007;66(3):334-40.
2007: Arjen B Blom; Peter van der Kraan; Wim B van den Berg
Cytokine targeting in osteoarthritis.
Current drug targets 2007;8(2):283-92.
2007: Arjen B Blom; P L E M van Lent; Sten Libregts; A E M Holthuysen; Peter van der Kraan; Nico van Rooijen; Wim B van den Berg
Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3.
Arthritis and rheumatism 2007;56(1):147-57.
2006: P L E M van Lent; Lilyanne Grevers; Erik Lubberts; Teun J de Vries; K C A M Nabbe; Sjef Verbeek; Birgit Oppers; Annet Sloetjes; Arjen B Blom; Wim B van den Berg
Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: uncoupling of cartilage damage from bone erosion and joint inflammation.
Arthritis and rheumatism 2006;54(12):3868-77.
2005: P L E M van Lent; K C A M Nabbe; Arjen B Blom; Annet Sloetjes; A E M Holthuysen; Jay K Kolls; Fons A J van de Loo; Steven M Holland; Wim B van den Berg
NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-gamma-stimulated immune complex arthritis.
Arthritis research & therapy 2005;7(4):R885-95.
2004: Timothy Radstake; Arjen B Blom; Annet W Slöetjes; E O F van Gorselen; Gerard J Pesman; Linda P H Engelen; Ruurd Torensma; Wim B van den Berg; Carl G Figdor; P L E M van Lent; Gosse J Adema; Pilar Barrera
Increased FcgammaRII expression and aberrant tumour necrosis factor alpha production by mature dendritic cells from patients with active rheumatoid arthritis.
Annals of the rheumatic diseases 2004;63(12):1556-63.
2004: Arjen B Blom; P L E M van Lent; A E M Holthuysen; Peter van der Kraan; Johannes Roth; Nico van Rooijen; Wim B van den Berg
Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(8):627-35.
2004: Timothy Radstake; P L E M van Lent; Gerard J Pesman; Arjen B Blom; Fred G J Sweep; J Rönnelid; Gosse J Adema; Pilar Barrera; Wim B van den Berg
High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcgammaR triggering.
Annals of the rheumatic diseases 2004;63(6):696-702.
2004: P L E M van Lent; Arjen B Blom; Peter van der Kraan; A E M Holthuysen; Elly L Vitters; Nico van Rooijen; Ruben L Smeets; K C A M Nabbe; Wim B van den Berg
Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation.
Arthritis and rheumatism 2004;50(1):103-11.
2003: P L E M van Lent; K C A M Nabbe; Peter I Boross; Arjen B Blom; Johannes Roth; A E M Holthuysen; Annet Sloetjes; Sjef Verbeek; Wim B van den Berg
The inhibitory receptor FcgammaRII reduces joint inflammation and destruction in experimental immune complex-mediated arthritides not only by inhibition of FcgammaRI/III but also by efficient clearance and endocytosis of immune complexes.
The American journal of pathology 2003;163(5):1839-48.
2003: Arjen B Blom; P L E M van Lent; A E M Holthuysen; C Jacobs; Wim B van den Berg
Skewed balance in basal expression and regulation of activating v inhibitory Fcgamma receptors in macrophages of collagen induced arthritis sensitive mice.
Annals of the rheumatic diseases 2003;62(5):465-71.
2003: Arjen B Blom; Timothy Radstake; A E M Holthuysen; Annet W Slöetjes; Gerard J Pesman; Fred G J Sweep; Fons A J van de Loo; Leo A B Joosten; Pilar Barrera; P L E M van Lent; Wim B van den Berg
Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase.
Arthritis and rheumatism 2003;48(4):1002-14.
2003: K C A M Nabbe; Arjen B Blom; A E M Holthuysen; Peter I Boross; Johannes Roth; Sjef Verbeek; P L E M van Lent; Wim B van den Berg
Coordinate expression of activating Fc gamma receptors I and III and inhibiting Fc gamma receptor type II in the determination of joint inflammation and cartilage destruction during immune complex-mediated arthritis.
Arthritis and rheumatism 2003;48(1):255-65.
2001: P L E M van Lent; K C A M Nabbe; Arjen B Blom; A E M Holthuysen; Annet Sloetjes; L B A Van De Putte; Sjef Verbeek; Wim B van den Berg
Role of activatory Fc gamma RI and Fc gamma RIII and inhibitory Fc gamma RII in inflammation and cartilage destruction during experimental antigen-induced arthritis.
The American journal of pathology 2001;159(6):2309-20.
2000: P L E M van Lent; A J van Vuuren; Arjen B Blom; A E M Holthuysen; L B A Van De Putte; J G van de Winkel; Wim B van den Berg
Role of Fc receptor gamma chain in inflammation and cartilage damage during experimental antigen-induced arthritis.
Arthritis and rheumatism 2000;43(4):740-52.
2000: Arjen B Blom; P L E M van Lent; H van Vuuren ; A E M Holthuysen; C Jacobs; L B A Van De Putte; J G van de Winkel ; Wim B van den Berg
Fc gamma R expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA).
Arthritis research 2000;2(6):489-503.
1999: Arjen B Blom; P L E M van Lent; A E M Holthuysen; Wim B van den Berg
Immune complexes, but not streptococcal cell walls or zymosan, cause chronic arthritis in mouse strains susceptible for collagen type II auto-immune arthritis.
Cytokine 1999;11(12):1046-56.