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Henk Blom

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Suzanne C van Dijk; Natasja M van Schoor; Janneke P van Wijngaarden; Henk J Blom; Lisette C P G M de Groot; Rosalie A M Dhonukshe-Rutten; Anke W Enneman; Edith J Feskens; Johanna M Geleijnse; Annelies C Ham; Paul Lips; Francesco Mattace Raso; Yvo M Smulders; Karin M A Swart; Andre G Uitterlinden; Anton H van den Meiracker; Nathalie van der Velde
Homocysteine level is associated with aortic stiffness in elderly: cross-sectional results from the B-PROOF study.
Audrey Y Jung; Henk J Blom; Akke Botma; Gry Kvalheim; Carolien Lute; Fokko Nagengast; Wilma Steegenga; Per M Ueland; Øivind Midttun; Ellen Kampman
Plasma B vitamins and LINE-1 DNA methylation in leukocytes of patients with a history of colorectal adenomas.
Ruben Esse; Cristina Florindo; Robert M Kok; PIETER KOOLWIJK; Paula Leandro; Isabel Rivera; Monica S Rocha; Yvo M Smulders; Tom Teerlink; Madalena Barroso; Henk J Blom; Rita Castro; Isabel Tavares de Almeida
Protein arginine methylation is more prone to inhibition by S-adenosylhomocysteine than DNA methylation in vascular endothelial cells.

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2013: Suzanne C van Dijk; Natasja M van Schoor; Janneke P van Wijngaarden; Henk J Blom; Lisette C P G M de Groot; Rosalie A M Dhonukshe-Rutten; Anke W Enneman; Edith J Feskens; Johanna M Geleijnse; Annelies C Ham; Paul Lips; Francesco Mattace Raso; Yvo M Smulders; Karin M A Swart; Andre G Uitterlinden; Anton H van den Meiracker; Nathalie van der Velde
Homocysteine level is associated with aortic stiffness in elderly: cross-sectional results from the B-PROOF study.
Journal of hypertension 2013;31(5):952-9.
2013: Audrey Y Jung; Henk J Blom; Akke Botma; Gry Kvalheim; Carolien Lute; Fokko Nagengast; Wilma Steegenga; Per M Ueland; Øivind Midttun; Ellen Kampman
Plasma B vitamins and LINE-1 DNA methylation in leukocytes of patients with a history of colorectal adenomas.
Molecular nutrition & food research 2013;57(4):698-708.
2013: Ruben Esse; Cristina Florindo; Robert M Kok; PIETER KOOLWIJK; Paula Leandro; Isabel Rivera; Monica S Rocha; Yvo M Smulders; Tom Teerlink; Madalena Barroso; Henk J Blom; Rita Castro; Isabel Tavares de Almeida
Protein arginine methylation is more prone to inhibition by S-adenosylhomocysteine than DNA methylation in vascular endothelial cells.
PloS one 2013;8(2):e55483.
2013: Johanna C Harteman; Albert Huisman; Manon Benders; Henk J Blom; Floris Groenendaal; Linda S de Vries
Role of thrombophilic factors in full-term infants with neonatal encephalopathy.
Pediatric research 2013;73(1):80-6.
2012: Desirée E C Smith; Yvo M Smulders; Mirian C H Janssen; Leo A J Kluijtmans; Marisa I S Mendes; Henk J Blom
A liquid chromatography mass spectrometry method for the measurement of cystathionine β-synthase activity in cell extracts.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;911():186-91.
2012: K M A Swart; Natasja M van Schoor; Henk J Blom; Y M Smulders; P Lips
Homocysteine and the risk of nursing home admission and mortality in older persons.
European journal of clinical nutrition 2012;66(2):188-95.
2011: Mirjam M C Wamelink; Eduard A Struys; Erwin E W Jansen; Henk J Blom; T Vilboux; W A Gahl; M Kömhoff; Cornelis Jakobs; Elena N Levtchenko
Elevated concentrations of sedoheptulose in bloodspots of patients with cystinosis caused by the 57-kb deletion: implications for diagnostics and neonatal screening.
Molecular genetics and metabolism 2011;102(3):339-42.
2010: Marije Hogeveen; Martin den Heijer; Y Schonbeck; M Ijland; D van Oppenraaij; Jacqueline Klein Gunnewiek; Henk J Blom
The effect of folinic acid supplementation on homocysteine concentrations in newborns.
European journal of clinical nutrition 2010;64(11):1266-71.
2010: Marije Hogeveen; Henk J Blom; Elisabeth H van der Heijden; Ben A Semmekrot; Jan M Sporken; Per Magne Ueland; Martin den Heijer
Maternal homocysteine and related B vitamins as risk factors for low birthweight.
American journal of obstetrics and gynecology 2010;202(6):572.e1-6.
2010: Ingrid M Van Beynum; Livia Kapusta; Marian K Bakker; Martin den Heijer; Henk J Blom; Hermien E K de Walle
Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands.
European heart journal 2010;31(4):464-71.
2010: Bart L T Vaes; Carolien Lute; Sebastian P van der Woning; Ester Piek; Jenny Vermeer; Henk J Blom; John C Mathers; Michael Müller; Lisette C P G M de Groot; Wilma T Steegenga
Inhibition of methylation decreases osteoblast differentiation via a non-DNA-dependent methylation mechanism.
Bone 2010;46(2):514-23.
2010: Eva Kolwijck; Ron A Wevers; Udo F H Engelke; Jannes Woudenberg; Johan Bulten; Henk J Blom; L F A G Massuger
Ovarian cyst fluid of serous ovarian tumors contains large quantities of the brain amino acid N-acetylaspartate.
PloS one 2010;5(4):e10293.
2009: Eva Kolwijck; Udo F H Engelke; Marinette van der Graaf; Arend Heerschap; Henk J Blom; M'hamed Hadfoune; Wim A Buurman; L F A G Massuger; Ron A Wevers
N-acetyl resonances in in vivo and in vitro NMR spectroscopy of cystic ovarian tumors.
NMR in biomedicine 2009;22(10):1093-9.
2009: Carlijn R Hooijmans; Henk J Blom; Dinny Oppenraaij-Emmerzaal; Merel Ritskes-Hoitinga; Amanda J Kiliaan
S-adenosylmethionine and S-adenosylhomocysteine levels in the aging brain of APP/PS1 Alzheimer mice.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2009;30(5):439-45.
2009: Gepke Visser; Francjan J van Spronsen; Monique G M de Sain-Van Der Velden; Henk J Blom; Frits A Wijburg
[Extensive neonatal heel injection screening for metabolic diseases in the Netherlands].
Nederlands tijdschrift voor geneeskunde 2009;153(18):848-53.
2009: Bart L T Vaes; Carolien Lute; Henk J Blom; Nathalie Bravenboer; Teun J de Vries; Vincent Everts; Rosalie A M Dhonukshe-Rutten; Michael Müller; Lisette C P G M de Groot; Wilma T Steegenga
Vitamin B(12) deficiency stimulates osteoclastogenesis via increased homocysteine and methylmalonic acid.
Calcified tissue international 2009;84(5):413-22.
2009: Barbara Franke; Sita H H M Vermeulen; Régine P M Steegers-Theunissen; Marieke Coenen; Mascha M V A P Schijvenaars; Hans Scheffer; Martin den Heijer; Henk J Blom
An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).
Birth defects research. Part A, Clinical and molecular teratology 2009;85(3):216-26.
2008: Ivon J M van der Linden; Sandra G Heil; Michael van Egmont Petersen; Henny W M van Straaten; Martin den Heijer; Henk J Blom
Inhibition of methylation and changes in gene expression in relation to neural tube defects.
Birth defects research. Part A, Clinical and molecular teratology 2008;82(10):676-83.
2008: Simone J P M Eussen; Per Magne Ueland; Gerrit J Hiddink; Jörn Schneede; Henk J Blom; Willibrord H L Hoefnagels; Wija A van Staveren; Lisette C P G M de Groot
Changes in markers of cobalamin status after cessation of oral B-vitamin supplements in elderly people with mild cobalamin deficiency.
European journal of clinical nutrition 2008;62(10):1248-51.
2008: Jan-Willem Muntjewerff; Henkjan Gellekink; Martin den Heijer; Mechteld L C Hoogendoorn; René S Kahn; Richard J Sinke; Henk J Blom
Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2008;18(2):99-106.
2008: Ingrid M Van Beynum; Christiaan Mooij; Livia Kapusta; Sandra Heil; Martin den Heijer; Henk J Blom
Common 894G>T single nucleotide polymorphism in the gene coding for endothelial nitric oxide synthase (eNOS) and risk of congenital heart defects.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2008;46(10):1369-75.
2008: Sandra G Heil; Sita H Vermeulen; Brenda J M Van der Rijt-Pisa; Martin den Heijer; Henk J Blom
Role for mitochondrial uncoupling protein-2 (UCP2) in hyperhomocysteinemia and venous thrombosis risk?
Clinical chemistry and laboratory medicine : CCLM / FESCC 2008;46(5):655-9.
2007: Henkjan Gellekink; Jan-Willem Muntjewerff; Sita H H M Vermeulen; Ad R M M Hermus; Henk J Blom; Martin den Heijer
Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk.
Thrombosis and haemostasis 2007;98(6):1226-31.
2007: Ingrid M Van Beynum; Martin den Heijer; Henk J Blom; Livia Kapusta
The MTHFR 677C->T polymorphism and the risk of congenital heart defects: a literature review and meta-analysis.
QJM : monthly journal of the Association of Physicians 2007;100(12):743-53.
2007: Ivon J M van der Linden; Sandra G Heil; I C Kouwenberg; M den Heijer; Henk J Blom
The methylenetetrahydrofolate dehydrogenase (MTHFD1) 1958G>A variant is not associated with spina bifida risk in the Dutch population.
Clinical genetics 2007;72(6):599-600.
2007: Simone J P M Eussen; Per Magne Ueland; Robert Clarke; Henk J Blom; Willibrord H L Hoefnagels; Wija A van Staveren; Lisette C P G M de Groot
The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people.
The British journal of nutrition 2007;98(5):960-8.
2007: Jan-Willem Muntjewerff; Mechteld L C Hoogendoorn; Maartje F Aukes; René S Kahn; Richard J Sinke; Henk J Blom; Martin den Heijer
No evidence for a preferential transmission of the methylenetetrahydrofolate reductase 677T allele in families with schizophrenia offspring.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(7):891-4.
2007: Sandra G Heil; Marije Hogeveen; Leo A J Kluijtmans; P J van Dijken; Gerard B van de Berg; Henk J Blom; Eva Morava
Marfanoid features in a child with combined methylmalonic aciduria and homocystinuria (CblC type).
Journal of inherited metabolic disease 2007;30(5):811.
2007: Martijn J G Wilmer; Peter H G M Willems; Sjoerd Verkaart; Henk-Jan Visch; Adriana de Graaf-Hess; Henk J Blom; Leo A H Monnens; Lambert P van den Heuvel; Elena N Levtchenko
Cystine dimethylester model of cystinosis: still reliable?
Pediatric research 2007;62(2):151-5.
2007: Sandra G Heil; Leo A J Kluijtmans; An S De Vriese; Rolph Pfundt; Henk J Blom
Diet-induced hyperhomocysteinemia does not lead to large gene-expression differences in rat aorta.
Atherosclerosis 2007;193(2):452-4.
2007: Sandra G Heil; Niels P Riksen; Godfried H J Boers; Yvo Smulders; Henk J Blom
DNA methylation status is not impaired in treated cystathionine beta-synthase (CBS) deficient patients.
Molecular genetics and metabolism 2007;91(1):55-60.
2007: Ivon J M van der Linden; Uyen Nguyen; Sandra G Heil; Barbara Franke; Suzanne Vloet; Henkjan Gellekink; Martin den Heijer; Henk J Blom
Variation and expression of dihydrofolate reductase (DHFR) in relation to spina bifida.
Molecular genetics and metabolism 2007;91(1):98-103.
2007: Anita C T M Peeters; Bart A van Landeghem; Sietze Graafsma; Steef E Kranendonk; Ad R M M Hermus; Henk J Blom; Martin den Heijer
Low vitamin B6, and not plasma homocysteine concentration, as risk factor for abdominal aortic aneurysm: a retrospective case-control study.
Journal of vascular surgery 2007;45(4):701-5.
2007: Henk J Blom; Arno van Rooij; Marije Hogeveen
A simple high-throughput method for the determination of plasma methylmalonic acid by liquid chromatography-tandem mass spectrometry.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2007;45(5):645-50.
2007: Ivon J M van der Linden; Sandra G Heil; Martin den Heijer; Henk J Blom
The 894G>T variant in the endothelial nitric oxide synthase gene and spina bifida risk.
Journal of human genetics 2007;52(6):516-20.
2007: Henkjan Gellekink; Henk J Blom; Martin den Heijer
Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis risk.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2007;45(4):471-6.
2007: Anita C T M Peeters; Benien E van Aken; Henk J Blom; Pieter H Reitsma; Martin den Heijer
The effect of homocysteine reduction by B-vitamin supplementation on inflammatory markers.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2007;45(1):54-8.
2007: Miranda B A J Keijzer; George F Borm; Henk J Blom; Gerard M J Bos; Frits R Rosendaal; Martin den Heijer
No interaction between factor V Leiden and hyperhomocysteinemia or MTHFR 677TT genotype in venous thrombosis. Results of a meta-analysis of published studies and a large case-only study.
Thrombosis and haemostasis 2007;97(1):32-7.
2007: Henkjan Gellekink; Henk J Blom; Ivon J M van der Linden; Martin den Heijer
Molecular genetic analysis of the human dihydrofolate reductase gene: relation with plasma total homocysteine, serum and red blood cell folate levels.
European journal of human genetics : EJHG 2007;15(1):103-9.
2007: Martin den Heijer; Huub P J Willems; Henk J Blom; Wim B J Gerrits; Marco Cattaneo; Sabine Eichinger; Frits R Rosendaal; Gerard M J Bos
Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial.
Blood 2007;109(1):139-44.
2006: Ivon J M van der Linden; Martin den Heijer; Lydia A Afman; Henkjan Gellekink; Sita H H M Vermeulen; Leo A J Kluijtmans; Henk J Blom
The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida.
Journal of molecular medicine (Berlin, Germany) 2006;84(12):1047-54.
2006: Miranda B A J Keijzer; Martin den Heijer; George F Borm; Henk J Blom; Stein Emil Vollset; Ad R M M Hermus; Per Magne Ueland
Low fasting methionine concentration as a novel risk factor for recurrent venous thrombosis.
Thrombosis and haemostasis 2006;96(4):492-7.
2006: Karin J A Lievers; Leo A J Kluijtmans; Henk J Blom; Peter W Wilson; Jacob Selhub; Jose Ordovas
Association of a 31 bp VNTR in the CBS gene with postload homocysteine concentrations in the Framingham Offspring Study.
European journal of human genetics : EJHG 2006;14(10):1125-9.
2006: Henk J Blom; Gary M Shaw; Martin den Heijer; Richard Finnell
Neural tube defects and folate: case far from closed.
Nature reviews. Neuroscience 2006;7(9):724-31.
2006: Simone J P M Eussen; Lisette C P G M de Groot; Liesbeth W Joosten; Rubia J Bloo; Robert Clarke; Per Magne Ueland; Jörn Schneede; Henk J Blom; Willibrord H L Hoefnagels; Wija A van Staveren
Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial.
The American journal of clinical nutrition 2006;84(2):361-70.
2006: Sita H H M Vermeulen; Gerly M van der Vleuten; Jacqueline de Graaf; Ad R M M Hermus; Henk J Blom; Anton F H Stalenhoef; Martin den Heijer
A genome-wide linkage scan for homocysteine levels suggests three regions of interest.
Journal of thrombosis and haemostasis : JTH 2006;4(6):1303-7.
2006: Gerly M van der Vleuten; Leo A J Kluijtmans; Anneke Hijmans; Henk J Blom; Anton F H Stalenhoef; Jacqueline de Graaf
The Gln223Arg polymorphism in the leptin receptor is associated with familial combined hyperlipidemia.
International journal of obesity (2005) 2006;30(6):892-8.
2006: Ivon J M van der Linden; Lydia A Afman; Sandra G Heil; Henk J Blom
Genetic variation in genes of folate metabolism and neural-tube defect risk.
The Proceedings of the Nutrition Society 2006;65(2):204-15.
2006: Gerly M van der Vleuten; Anneke Hijmans; Sandra Heil; Henk J Blom; Anton F H Stalenhoef; Jacqueline de Graaf
Can we exclude the TXNIP gene as a candidate gene for familial combined hyperlipidemia?
American journal of medical genetics. Part A 2006;140(9):1010-2.
2006: Ingrid M Van Beynum; Livia Kapusta; Martin den Heijer; Sita H H M Vermeulen; Margreet Kouwenberg; Otto Daniëls; Henk J Blom
Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation.
European heart journal 2006;27(8):981-7.
2006: H P J Willems; M den Heijer; Wim B J Gerrits; Leon J Schurgers; M Havekes; Henk J Blom; Gerard M J Bos
Oral anticoagulant treatment with coumarin derivatives does not influence plasma homocysteine concentration.
European journal of internal medicine 2006;17(2):120-4.
2006: Miranda B A J Keijzer; Petra Verhoef; George F Borm; Henk J Blom; Martin den Heijer
No added value of the methionine loading task in assessment for venous thrombosis and cardiovascular disease risk.
Thrombosis and haemostasis 2006;95(2):380-5.
2006: Elena N Levtchenko; Martijn J G Wilmer; Antoon J M Janssen; Jan B Koenderink; Henk-Jan Visch; Peter H G M Willems; Adriana de Graaf-Hess; Henk J Blom; Lambert P van den Heuvel; Leo A H Monnens
Decreased intracellular ATP content and intact mitochondrial energy generating capacity in human cystinotic fibroblasts.
Pediatric research 2006;59(2):287-92.
2006: Jan-Willem Muntjewerff; René S Kahn; Henk J Blom; Martin den Heijer
Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis.
Molecular psychiatry 2006;11(2):143-9.
2006: Ingrid M Van Beynum; Margreet Kouwenberg; Livia Kapusta; Martin den Heijer; Ivon J M van der Linden; Otto Daniels; Henk J Blom
MTRR 66A>G polymorphism in relation to congenital heart defects.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2006;44(11):1317-23.
2006: Elena N Levtchenko; Carin M van Dael; Adriana de Graaf-Hess; Martijn J G Wilmer; Lambert P van den Heuvel; Leo A H Monnens; Henk J Blom
Strict cysteamine dose regimen is required to prevent nocturnal cystine accumulation in cystinosis.
Pediatric nephrology (Berlin, Germany) 2006;21(1):110-3.
2005: Martijn J G Wilmer; Adriana de Graaf-Hess; Henk J Blom; Henry B P M Dijkman; Leo A H Monnens; Lambert P van den Heuvel; Elena N Levtchenko
Elevated oxidized glutathione in cystinotic proximal tubular epithelial cells.
Biochemical and biophysical research communications 2005;337(2):610-4.
2005: Rosalie A M Dhonukshe-Rutten; Moniek van Zutphen; Lisette C P G M de Groot; Simone J P M Eussen; Henk J Blom; Wija A van Staveren
Effect of supplementation with cobalamin carried either by a milk product or a capsule in mildly cobalamin-deficient elderly Dutch persons.
The American journal of clinical nutrition 2005;82(3):568-74.
2005: Jan-Willem Muntjewerff; Henk J Blom
Aberrant folate status in schizophrenic patients: what is the evidence?
Progress in neuro-psychopharmacology & biological psychiatry 2005;29(7):1133-9.
2005: Lydia A Afman; Henk J Blom; Marie-Jose Drittij; Madeleine R Brouns; Henny W M van Straaten
Inhibition of transmethylation disturbs neurulation in chick embryos.
Brain research. Developmental brain research 2005;158(1-2):59-65.
2005: Henkjan Gellekink; Dinny van Oppenraaij-Emmerzaal; Arno van Rooij; Eduard A Struys; Martin den Heijer; Henk J Blom
Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma.
Clinical chemistry 2005;51(8):1487-92.
2005: Jan-Willem Muntjewerff; Mechteld L C Hoogendoorn; René S Kahn; Richard J Sinke; Martin den Heijer; Leo A J Kluijtmans; Henk J Blom
Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677TT genotype, and the risk for schizophrenia: a Dutch population based case-control study.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;135B(1):69-72.
2005: Henkjan Gellekink; Martin den Heijer; Sandra G Heil; Henk J Blom
Genetic determinants of plasma total homocysteine.
Seminars in vascular medicine 2005;5(2):98-109.
2005: Ingrid M Van Beynum; Martin den Heijer; Chris M G Thomas; Lydia A Afman; Diny Oppenraay-van Emmerzaal; Henk J Blom
Total homocysteine and its predictors in Dutch children.
The American journal of clinical nutrition 2005;81(5):1110-6.
2005: Angelika de Bree; N M J van der Put; Louise Mennen; W M Monique Verschuren; Henk J Blom; Pilar Galan; C J Bates; W Herrmann; M Ullrich; J Dierkes; S Westphal; L M Bouter; R J Heine; C D A Stehouwer; J M Dekker; G N Nijpels; F Araújo; Luis Manuel Cunha-Ribeiro; H Refsum; S Vollset; O Nygard; Per Magne Ueland
Prevalences of hyperhomocysteinemia, unfavorable cholesterol profile and hypertension in European populations.
European journal of clinical nutrition 2005;59(4):480-8.
2005: Pål I Holm; Per Magne Ueland; Stein Emil Vollset; Øivind Midttun; Henk J Blom; Miranda B A J Keijzer; Martin den Heijer
Betaine and folate status as cooperative determinants of plasma homocysteine in humans.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(2):379-85.
2005: Niels P Riksen; Gerard A Rongen; Henk J Blom; Godfried H J Boers; Paul Smits
Reduced adenosine receptor stimulation as a pathogenic factor in hyperhomocysteinemia.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2005;43(10):1001-6.
2005: Sandra G Heil; An S De Vriese; Leo A J Kluijtmans; Henry B P M Dijkman; Denise van Strien; Robert Akkers; Henk J Blom
Cytochrome P450-2C11 mRNA is not expressed in endothelial cells dissected from rat renal arterioles.
Nephron. Physiology 2005;99(2):p43-9.
2005: Niels P Riksen; Gerard A Rongen; Godfried H J Boers; Henk J Blom; Petra H H van den Broek; Paul Smits
Enhanced cellular adenosine uptake limits adenosine receptor stimulation in patients with hyperhomocysteinemia.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(1):109-14.
2004: Sandra G Heil; An S De Vriese; Leo A J Kluijtmans; Siska Mortier; Martin den Heijer; Henk J Blom
The role of hyperhomocysteinemia in nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilatation.
Cellular and molecular biology (Noisy-le-Grand, France) 2004;50(8):911-6.
2004: Anita C T M Peeters; Els F van der Molen; Henk J Blom; Martin den Heijer
The effect of homocysteine reduction by B-vitamin supplementation on markers of endothelial dysfunction.
Thrombosis and haemostasis 2004;92(5):1086-91.
2004: Henkjan Gellekink; Martin den Heijer; Leo A J Kluijtmans; Henk J Blom
Effect of genetic variation in the human S-adenosylhomocysteine hydrolase gene on total homocysteine concentrations and risk of recurrent venous thrombosis.
European journal of human genetics : EJHG 2004;12(11):942-8.
2004: Huub P J Willems; Martin den Heijer; Jan Lindemans; Henriette W A Berenschot; Wim B J Gerrits; Gerard M J Bos; Henk J Blom
Measurement of total homocysteine concentrations in acidic citrate- and EDTA-containing tubes by different methods.
Clinical chemistry 2004;50(10):1881-3.
2004: Gerly M van der Vleuten; Anneke Hijmans; Leo A J Kluijtmans; Henk J Blom; Anton F H Stalenhoef; Jacqueline de Graaf
Thioredoxin interacting protein in Dutch families with familial combined hyperlipidemia.
American journal of medical genetics. Part A 2004;130A(1):73-5.
2004: Alida Melse-Boonstra; Karin J A Lievers; Henk J Blom; Petra Verhoef
Bioavailability of polyglutamyl folic acid relative to that of monoglutamyl folic acid in subjects with different genotypes of the glutamate carboxypeptidase II gene.
The American journal of clinical nutrition 2004;80(3):700-4.
2004: An S De Vriese; Henk J Blom; Sandra G Heil; Siska Mortier; Leo A J Kluijtmans; Johan Van de Voorde; Norbert H Lameire
Endothelium-derived hyperpolarizing factor-mediated renal vasodilatory response is impaired during acute and chronic hyperhomocysteinemia.
Circulation 2004;109(19):2331-6.
2004: Sandra G Heil; Martin den Heijer; B J M Van Der Rijt-Pisa; Leo A J Kluijtmans; Henk J Blom
The 894 G > T variant of endothelial nitric oxide synthase (eNOS) increases the risk of recurrent venous thrombosis through interaction with elevated homocysteine levels.
Journal of thrombosis and haemostasis : JTH 2004;2(5):750-3.
2003: Iris A L M van Rooij; Dorine W Swinkels; Henk J Blom; Hans M W M Merkus; Régine P M Steegers-Theunissen
Vitamin and homocysteine status of mothers and infants and the risk of nonsyndromic orofacial clefts.
American journal of obstetrics and gynecology 2003;189(4):1155-60.
2003: Niels P Riksen; Gerard A Rongen; Henk J Blom; Frans G M Russel; Godfried H J Boers; Paul Smits
Potential role for adenosine in the pathogenesis of the vascular complications of hyperhomocysteinemia.
Cardiovascular research 2003;59(2):271-6.
2003: Marika A Artz; Johannes M M Boots; Gerry Ligtenberg; Joke I Roodnat; Maarten H L Christiaans; Pieter F Vos; Henk J Blom; Fred C G J Sweep; Pierre N M Demacker; Luuk B Hilbrands
Improved cardiovascular risk profile and renal function in renal transplant patients after randomized conversion from cyclosporine to tacrolimus.
Journal of the American Society of Nephrology : JASN 2003;14(7):1880-8.
2003: Lydia A Afman; Henk J Blom; N M J van der Put; Henny W M van Straaten
Homocysteine interference in neurulation: a chick embryo model.
Birth defects research. Part A, Clinical and molecular teratology 2003;67(6):421-8.
2003: Mariska Klerk; Karin J A Lievers; Leo A J Kluijtmans; Henk J Blom; Martin den Heijer; Evert G Schouten; Frans J Kok; Petra Verhoef
The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study.
Thrombosis research 2003;110(2-3):87-91.
2003: Lydia A Afman; Karin J A Lievers; Leo A J Kluijtmans; Frans J M Trijbels; Henk J Blom
Gene-gene interaction between the cystathionine beta-synthase 31 base pair variable number of tandem repeats and the methylenetetrahydrofolate reductase 677C > T polymorphism on homocysteine levels and risk for neural tube defects.
Molecular genetics and metabolism 2003;78(3):211-5.
2003: Angelika de Bree; W M Monique Verschuren; Anne-Lise Bjørke-Monsen; N M J van der Put; Sandra G Heil; Frans J M Trijbels; Henk J Blom
Effect of the methylenetetrahydrofolate reductase 677C-->T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample.
The American journal of clinical nutrition 2003;77(3):687-93.
2003: Angelika de Bree; W M Monique Verschuren; Henk J Blom; Marie Nadeau; Frans J M Trijbels; Daan Kromhout
Coronary heart disease mortality, plasma homocysteine, and B-vitamins: a prospective study.
Atherosclerosis 2003;166(2):369-77.
2003: Dieneke Z B van Asselt; Chris M G Thomas; Martin F G Segers; Henk J Blom; Ron A Wevers; Willibrord H L Hoefnagels
Cobalamin-binding proteins in normal and cobalamin-deficient older subjects.
Annals of clinical biochemistry 2003;40(Pt 1):65-9.
2003: Karin J A Lievers; Leo A J Kluijtmans; Henk J Blom
Genetics of hyperhomocysteinaemia in cardiovascular disease.
Annals of clinical biochemistry 2003;40(Pt 1):46-59.
2003: Karin J A Lievers; Leo A J Kluijtmans; Sandra G Heil; Godfried H J Boers; Petra Verhoef; Martin den Heijer; Frans J M Trijbels; Henk J Blom
Cystathionine beta-synthase polymorphisms and hyperhomocysteinaemia: an association study.
European journal of human genetics : EJHG 2003;11(1):23-9.
2003: Lydia A Afman; Frans J M Trijbels; Henk J Blom
The H475Y polymorphism in the glutamate carboxypeptidase II gene increases plasma folate without affecting the risk for neural tube defects in humans.
The Journal of nutrition 2003;133(1):75-7.
2003: Mario J Veerkamp; Jacqueline de Graaf; Martin den Heijer; Henk J Blom; Anton F H Stalenhoef
Plasma homocysteine in subjects with familial combined hyperlipidemia.
Atherosclerosis 2003;166(1):111-7.
2002: Angelika de Bree; W M Monique Verschuren; Daan Kromhout; Louise Mennen; Henk J Blom
Homocysteine and coronary heart disease: the importance of a distinction between low and high risk subjects.
International journal of epidemiology 2002;31(6):1268-72; author reply 1271-2.
2002: Angelika de Bree; W M Monique Verschuren; Daan Kromhout; Leo A J Kluijtmans; Henk J Blom
Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease.
Pharmacological reviews 2002;54(4):599-618.
2002: Miranda B A J Keijzer; Martin den Heijer; Henk J Blom; Gerard M J Bos; Huub P J Willems; Wim B J Gerrits; Frits R Rosendaal
Interaction between hyperhomocysteinemia, mutated methylenetetrahydrofolatereductase (MTHFR) and inherited thrombophilic factors in recurrent venous thrombosis.
Thrombosis and haemostasis 2002;88(5):723-8.
2002: Mariska Klerk; Petra Verhoef; Robert Clarke; Henk J Blom; Frans J Kok; Evert G Schouten
MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.
JAMA : the journal of the American Medical Association 2002;288(16):2023-31.
2002: Karin J A Lievers; Leo A J Kluijtmans; Godfried H J Boers; Petra Verhoef; Martin den Heijer; Frans J M Trijbels; Henk J Blom
Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk.
Atherosclerosis 2002;164(2):269-73.
2002: Marije Hogeveen; Henk J Blom; Marjolein Van Amerongen; Bas Boogmans; Ingrid M Van Beynum; Margot van de Bor
Hyperhomocysteinemia as risk factor for ischemic and hemorrhagic stroke in newborn infants.
The Journal of pediatrics 2002;141(3):429-31.
2002: Karin J A Lievers; Lydia A Afman; Leo A J Kluijtmans; Godfried H J Boers; Petra Verhoef; Martin den Heijer; Frans J M Trijbels; Henk J Blom
Polymorphisms in the transcobalamin gene: association with plasma homocysteine in healthy individuals and vascular disease patients.
Clinical chemistry 2002;48(9):1383-9.
2002: Mariska Klerk; Petra Verhoef; Bert Verbruggen; Evert G Schouten; Henk J Blom; Gerard M J Bos; Martin den Heijer
Effect of homocysteine reduction by B-vitamin supplementation on markers of clotting activation.
Thrombosis and haemostasis 2002;88(2):230-5.
2002: Marika A Artz; Johannes M M Boots; Gerry Ligtenberg; Joke I Roodnat; Maarten H L Christiaans; Ronald J Hené; Henk J Blom; Pierre N M Demacker; Luuk B Hilbrands
Randomized conversion from cyclosporine to tacrolimus in renal transplant patients: improved lipid profile and unchanged plasma homocysteine levels.
Transplantation proceedings 2002;34(5):1793-4.
2002: Lydia A Afman; Karin J A Lievers; N M J van der Put; Frans J M Trijbels; Henk J Blom
Single nucleotide polymorphisms in the transcobalamin gene: relationship with transcobalamin concentrations and risk for neural tube defects.
European journal of human genetics : EJHG 2002;10(7):433-8.
2002: Annelies van Ede; R F J M Laan; Henk J Blom; G H J Boers; Cees Haagsma; C M G Thomas; Theo M de Boo; L B A Van De Putte
Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis.
Rheumatology (Oxford, England) 2002;41(6):658-65.
2002: Elena N Levtchenko; Adriana de Graaf-Hess; Henk J Blom; Leo A H Monnens
Negligible urinary cysteamine loss in cystinosis patients with Fanconi syndrome.
Clinical nephrology 2002;57(5):349-51.
2002: Henk J Blom; An S De Vriese; S De Vriese
Why are homocysteine levels increased in kidney failure? A metabolic approach.
The Journal of laboratory and clinical medicine 2002;139(5):262-8.
2001: Dieneke Z B van Asselt; Jaco W Pasman; HJ van Lier; D M Vingerhoets; Patrick J P Poels; Y Kuin; Henk J Blom; Willibrord H L Hoefnagels
Cobalamin supplementation improves cognitive and cerebral function in older, cobalamin-deficient persons.
The journals of gerontology. Series A, Biological sciences and medical sciences 2001;56(12):M775-9.
2001: Annelies van Ede; R F J M Laan; Henk J Blom; Tom W J Huizinga; Cees Haagsma; Belinda A J Giesendorf; Theo M de Boo; L B A Van De Putte
The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients.
Arthritis and rheumatism 2001;44(11):2525-30.
2001: Karin J A Lievers; Godfried H J Boers; Petra Verhoef; Martin den Heijer; Leo A J Kluijtmans; N M J van der Put; Frans J M Trijbels; Henk J Blom
A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk.
Journal of molecular medicine (Berlin, Germany) 2001;79(9):522-8.
2001: Sandra G Heil; E Levtchenko; L A Monnens; Frans J M Trijbels; N M J van der Put; Henk J Blom
The molecular basis of Dutch infantile nephropathic cystinosis.
Nephron 2001;89(1):50-5.
2001: Karin J A Lievers; Leo A J Kluijtmans; Sandra G Heil; Godfried H J Boers; Petra Verhoef; D van Oppenraay-Emmerzaal; Martin den Heijer; Frans J M Trijbels; Henk J Blom
A 31 bp VNTR in the cystathionine beta-synthase (CBS) gene is associated with reduced CBS activity and elevated post-load homocysteine levels.
European journal of human genetics : EJHG 2001;9(8):583-9.
2001: Angelika de Bree; W M Monique Verschuren; Henk J Blom; Daan Kromhout
Lifestyle factors and plasma homocysteine concentrations in a general population sample.
American journal of epidemiology 2001;154(2):150-4.
2001: Angelika de Bree; W M Monique Verschuren; Henk J Blom; Daan Kromhout
Alcohol consumption and plasma homocysteine: what's brewing?
International journal of epidemiology 2001;30(3):626-7.
2001: Sandra G Heil; N M J van der Put; Erwin T Waas; Martin den Heijer; Frans J M Trijbels; Henk J Blom
Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects?
Molecular genetics and metabolism 2001;73(2):164-72.
2001: Angelika de Bree; W M Monique Verschuren; Henk J Blom; Daan Kromhout
Association between B vitamin intake and plasma homocysteine concentration in the general Dutch population aged 20-65 y.
The American journal of clinical nutrition 2001;73(6):1027-33.
2001: Angelika de Bree; W M Monique Verschuren; Henk J Blom; A de Graaf-Hess; Frans J M Trijbels; Daan Kromhout
The homocysteine distribution: (mis)judging the burden.
Journal of clinical epidemiology 2001;54(5):462-9.
2001: N M J van der Put; Henny W M van Straaten; Frans J M Trijbels; Henk J Blom
Folate, homocysteine and neural tube defects: an overview.
Experimental biology and medicine (Maywood, N.J.) 2001;226(4):243-70.
2001: M L Smit; Belinda A J Giesendorf; Jacqueline Vet; Frans J M Trijbels; Henk J Blom
Semiautomated DNA mutation analysis using a robotic workstation and molecular beacons.
Clinical chemistry 2001;47(4):739-44.
2001: Lydia A Afman; N M J van der Put; Chris M G Thomas; J M F Trijbels; Henk J Blom
Reduced vitamin B12 binding by transcobalamin II increases the risk of neural tube defects.
QJM : monthly journal of the Association of Physicians 2001;94(3):159-66.
2001: Angelika de Bree; W M Monique Verschuren; Henk J Blom
Biological cardiovascular risk factors and plasma homocysteine levels in the general Dutch population.
Atherosclerosis 2001;154(2):513-4.
2001: Henk J Blom
Mutated 5,10-methylenetetrahydrofolate reductase, hyperhomocysteinemia and risk for cardiovascular disease. Nature, nurture or nonsense?
European journal of clinical investigation 2001;31(1):6-8.
2000: Henk J Blom
Genetic determinants of hyperhomocysteinaemia: the roles of cystathionine beta-synthase and 5,10-methylenetetrahydrofolate reductase.
European journal of pediatrics 2000;159 Suppl 3():S208-12.
2000: W L D M Nelen; Henk J Blom; Eric A P Steegers; M den Heijer; Tom K A B Eskes
Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis.
Fertility and sterility 2000;74(6):1196-9.
2000: Sandra G Heil; Karin J A Lievers; Godfried H J Boers; Petra Verhoef; Martin den Heijer; Frans J M Trijbels; Henk J Blom
Betaine-homocysteine methyltransferase (BHMT): genomic sequencing and relevance to hyperhomocysteinemia and vascular disease in humans.
Molecular genetics and metabolism 2000;71(3):511-9.
2000: M L Smit; Belinda A J Giesendorf; Sandra G Heil; Jacqueline Vet; Frans J M Trijbels; Henk J Blom
Automated extraction and amplification of DNA from whole blood using a robotic workstation and an integrated thermocycler.
Biotechnology and applied biochemistry 2000;32 ( Pt 2)():121-5.
2000: N M J van der Put; Henk J Blom
Neural tube defects and a disturbed folate dependent homocysteine metabolism.
European journal of obstetrics, gynecology, and reproductive biology 2000;92(1):57-61.
2000: Dieneke Z B van Asselt; Henk J Blom; R Zuiderent; Ron A Wevers; C Jakobs; W J van den Broek; C B Lamers; F H Corstens; Willibrord H L Hoefnagels
Clinical significance of low cobalamin levels in older hospital patients.
The Netherlands journal of medicine 2000;57(2):41-9.
2000: EF van der Molen; B Verbruggen; Irena R O Nováková; Tom K A B Eskes; L A Monnens; Henk J Blom
Hyperhomocysteinemia and other thrombotic risk factors in women with placental vasculopathy.
BJOG : an international journal of obstetrics and gynaecology 2000;107(6):785-91.
2000: EF van der Molen; G E Arends; W L D M Nelen; N J van der Put; Sandra G Heil; Tom K A B Eskes; Henk J Blom
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene as a new risk factor for placental vasculopathy.
American journal of obstetrics and gynecology 2000;182(5):1258-63.
2000: Petra L M Zusterzeel; W L D M Nelen; Hennie M J Roelofs; Wilbert H M Peters; Henk J Blom; Eric A P Steegers
Polymorphisms in biotransformation enzymes and the risk for recurrent early pregnancy loss.
Molecular human reproduction 2000;6(5):474-8.
2000: W L D M Nelen; Johan Bulten; Eric A P Steegers; Henk J Blom; A G J M Hanselaar; Tom K A B Eskes
Maternal homocysteine and chorionic vascularization in recurrent early pregnancy loss.
Human reproduction (Oxford, England) 2000;15(4):954-60.
2000: W L D M Nelen; Henk J Blom; Eric A P Steegers; M den Heijer; Chris M G Thomas; Tom K A B Eskes
Homocysteine and folate levels as risk factors for recurrent early pregnancy loss.
Obstetrics and gynecology 2000;95(4):519-24.
2000: Ingeborg A Brouwer; Iris A L M van Rooij; Marijke Van Dusseldorp; Chris M G Thomas; Henk J Blom; Joseph G A J Hautvast; Tom K A B Eskes; Régine P M Steegers-Theunissen
Homocysteine-lowering effect of 500 microg folic acid every other day versus 250 microg/day.
Annals of nutrition & metabolism 2000;44(5-6):194-7.
2000: Henk J Blom
Consequences of homocysteine export and oxidation in the vascular system.
Seminars in thrombosis and hemostasis 2000;26(3):227-32.
1999: Livia Kapusta; M L Haagmans; E A Steegers; M H M Cuypers; Henk J Blom; T K Eskes
Congenital heart defects and maternal derangement of homocysteine metabolism.
The Journal of pediatrics 1999;135(6):773-4.
1999: W Y Wong; Tom K A B Eskes; Anne Marie Kuijpers-Jagtman; P H Spauwen; Eric A P Steegers; Chris M G Thomas; B C Hamel; Henk J Blom; Régine P M Steegers-Theunissen
Nonsyndromic orofacial clefts: association with maternal hyperhomocysteinemia.
Teratology 1999;60(5):253-7.
1999: Ingrid M Van Beynum; Jan A M Smeitink; Martin den Heijer; M T te Poele Pothoff; Henk J Blom
Hyperhomocysteinemia: a risk factor for ischemic stroke in children.
Circulation 1999;99(16):2070-2.
1999: Sandra G Heil; N M J van der Put; Frans J M Trijbels; Fons J M Gabreëls; Henk J Blom
Molecular genetic analysis of human folate receptors in neural tube defects.
European journal of human genetics : EJHG 1999;7(3):393-6.
1999: Huub P J Willems; Martin den Heijer; Henk J Blom; Wim B J Gerrits; Frits R Rosendaal; Gerard M J Bos
[Hyperhomocysteinemia as a risk factor for venous thrombosis].
Nederlands tijdschrift voor geneeskunde 1999;143(11):552-6.
1999: Cees Haagsma; Henk J Blom; P L C M van Riel; M A van't Hof; Belinda A J Giesendorf; D van Oppenraaij-Emmerzaal; L B A Van De Putte
Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis.
Annals of the rheumatic diseases 1999;58(2):79-84.
1998: Martin den Heijer; Frits R Rosendaal; Henk J Blom; Wim B J Gerrits; Gerard M J Bos
Hyperhomocysteinemia and venous thrombosis: a meta-analysis.
Thrombosis and haemostasis 1998;80(6):874-7.
1998: Dieneke Z B van Asselt; L C de Groot; W A van Staveren; Henk J Blom; Ron A Wevers; I Biemond; Willibrord H L Hoefnagels
Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects.
The American journal of clinical nutrition 1998;68(2):328-34.
1998: W L D M Nelen; Henk J Blom; Chris M G Thomas; Eric A P Steegers; G H Boers; Tom K A B Eskes
Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages.
The Journal of nutrition 1998;128(8):1336-41.
1998: Leo A J Kluijtmans; Udo Wendel; E M Stevens; Lambert P van den Heuvel; Frans J M Trijbels; Henk J Blom
Identification of four novel mutations in severe methylenetetrahydrofolate reductase deficiency.
European journal of human genetics : EJHG 1998;6(3):257-65.
1998: N M J van der Put; Fons J M Gabreëls; E M Stevens; Jan A M Smeitink; Frans J M Trijbels; Tom K A B Eskes; Lambert P van den Heuvel; Henk J Blom
A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?
American journal of human genetics 1998;62(5):1044-51.
1998: Annelies van Ede; R F J M Laan; Henk J Blom; R A De Abreu; L B A Van De Putte
Methotrexate in rheumatoid arthritis: an update with focus on mechanisms involved in toxicity.
Seminars in arthritis and rheumatism 1998;27(5):277-92.
1998: Leo A J Kluijtmans; Godfried H J Boers; B Verbruggen; Frans J M Trijbels; I R Novakova; Henk J Blom
Homozygous cystathionine beta-synthase deficiency, combined with factor V Leiden or thermolabile methylenetetrahydrofolate reductase in the risk of venous thrombosis.
Blood 1998;91(6):2015-8.
1998: A J van der Ven; Henk J Blom; W Peters; L E Jacobs; T J Verver; P P Koopmans; Pierre N M Demacker; J W van der Meer
Glutathione homeostasis is disturbed in CD4-positive lymphocytes of HIV-seropositive individuals.
European journal of clinical investigation 1998;28(3):187-93.
1998: Martin den Heijer; Ingeborg A Brouwer; Gerard M J Bos; Henk J Blom; N M J van der Put; A P Spaans; Frits R Rosendaal; Chris M G Thomas; Hans L Haak; Pierre W Wijermans; Wim B J Gerrits
Vitamin supplementation reduces blood homocysteine levels: a controlled trial in patients with venous thrombosis and healthy volunteers.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(3):356-61.
1998: Belinda A J Giesendorf; Jacqueline Vet; S Tyagi; E J Mensink; Frans J M Trijbels; Henk J Blom
Molecular beacons: a new approach for semiautomated mutation analysis.
Clinical chemistry 1998;44(3):482-6.
1998: Frans A Hol; N M J van der Put; MP Geurds; Sandra G Heil; Frans J M Trijbels; Ben C J Hamel; Edwin C M Mariman; Henk J Blom
Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defects.
Clinical genetics 1998;53(2):119-25.
1998: Leo A J Kluijtmans; Martin den Heijer; P H Reitsma; Sandra G Heil; Henk J Blom; F R Rosendaal
Thermolabile methylenetetrahydrofolate reductase and factor V Leiden in the risk of deep-vein thrombosis.
Thrombosis and haemostasis 1998;79(2):254-8.
1998: Huub P J Willems; Gerard M J Bos; Wim B J Gerrits; Martin den Heijer; S Vloet; Henk J Blom
Acidic citrate stabilizes blood samples for assay of total homocysteine.
Clinical chemistry 1998;44(2):342-5.
1997: W L D M Nelen; EF van der Molen; Henk J Blom; Sandra G Heil; Eric A P Steegers; Tom K A B Eskes
Recurrent early pregnancy loss and genetic-related disturbances in folate and homocysteine metabolism.
British journal of hospital medicine 1997;58(10):511-3.
1997: Leo A J Kluijtmans; J J Kastelein; Jan Lindemans; Godfried H J Boers; Sandra G Heil; A V Bruschke; J W Jukema; Lambert P van den Heuvel; Frans J M Trijbels; G J Boerma; F W Verheugt; F Willems; Henk J Blom
Thermolabile methylenetetrahydrofolate reductase in coronary artery disease.
Circulation 1997;96(8):2573-7.
1997: Leo A J Kluijtmans; Godfried H J Boers; Frans J M Trijbels; H M van Lith-Zanders; Lambert P van den Heuvel; Henk J Blom
A common 844INS68 insertion variant in the cystathionine beta-synthase gene.
Biochemical and molecular medicine 1997;62(1):23-5.
1997: W L D M Nelen; Eric A P Steegers; Tom K A B Eskes; Henk J Blom
Genetic risk factor for unexplained recurrent early pregnancy loss.
Lancet 1997;350(9081):861.
1997: N M J van der Put; EF van der Molen; Leo A J Kluijtmans; Sandra G Heil; J M F Trijbels; Tom K A B Eskes; D Van Oppenraaij-Emmerzaal; R Banerjee; Henk J Blom
Sequence analysis of the coding region of human methionine synthase: relevance to hyperhomocysteinaemia in neural-tube defects and vascular disease.
QJM : monthly journal of the Association of Physicians 1997;90(8):511-7.
1997: N M J van der Put; Chris M G Thomas; Tom K A B Eskes; Frans J M Trijbels; Régine P M Steegers-Theunissen; Edwin C M Mariman; A De Graaf-Hess; Jan A M Smeitink; Henk J Blom
Altered folate and vitamin B12 metabolism in families with spina bifida offspring.
QJM : monthly journal of the Association of Physicians 1997;90(8):505-10.
1997: EF van der Molen; M J Hiipakka; H van Lith-Zanders; G H Boers; L P van den Heuvel; L A Monnens; Henk J Blom
Homocysteine metabolism in endothelial cells of a patient homozygous for cystathionine beta-synthase (CS) deficiency.
Thrombosis and haemostasis 1997;78(2):827-33.
1997: N M J van der Put; Tom K A B Eskes; Henk J Blom
Is the common 677C-->T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis.
QJM : monthly journal of the Association of Physicians 1997;90(2):111-5.
1997: Marius J van der Mooren; P N Demacker; Henk J Blom; YB de Rijke; R Rolland
The effect of sequential three-monthly hormone replacement therapy on several cardiovascular risk estimators in postmenopausal women.
Fertility and sterility 1997;67(1):67-73.
1996: D G Franken; Henk J Blom; Godfried H J Boers; A Tangerman; C M Thomas; Frans J M Trijbels
Thiamine (vitamin B1) supplementation does not reduce fasting blood homocysteine concentration in most homozygotes for homocystinuria.
Biochimica et biophysica acta 1996;1317(2):101-4.
1996: N M J van der Put; L P van den Heuvel; Régine P M Steegers-Theunissen; Frans J M Trijbels; Tom K A B Eskes; Edwin C M Mariman; M den Heyer; Henk J Blom
Decreased methylene tetrahydrofolate reductase activity due to the 677C-->T mutation in families with spina bifida offspring.
Journal of molecular medicine (Berlin, Germany) 1996;74(11):691-4.
1996: Martin den Heijer; Gerard M J Bos; I A Brouwer; Wim B J Gerrits; Henk J Blom
Variability of the methionine loading test: no effect of a low protein diet.
Annals of clinical biochemistry 1996;33 ( Pt 6)():551-4.
1996: D G Franken; Godfried H J Boers; Henk J Blom; J R Cruysberg; Frans J M Trijbels; B C Hamel
Prevalence of familial mild hyperhomocysteinemia.
Atherosclerosis 1996;125(1):71-80.
1996: Leo A J Kluijtmans; Godfried H J Boers; E M Stevens; W O Renier; Jan P Kraus; Frans J M Trijbels; L P van den Heuvel; Henk J Blom
Defective cystathionine beta-synthase regulation by S-adenosylmethionine in a partially pyridoxine responsive homocystinuria patient.
The Journal of clinical investigation 1996;98(2):285-9.
1996: T A Goddijn-Wessel; M G Wouters; E F van de Molen; M D Spuijbroek; Régine P M Steegers-Theunissen; Henk J Blom; G H Boers; Tom K A B Eskes
Hyperhomocysteinemia: a risk factor for placental abruption or infarction.
European journal of obstetrics, gynecology, and reproductive biology 1996;66(1):23-9.
1996: EF van der Molen; L P van den Heuvel; M T te Poele Pothoff; I A Monnens; Tom K A B Eskes; Henk J Blom
The effect of folic acid on the homocysteine metabolism in human umbilical vein endothelial cells (HUVECs).
European journal of clinical investigation 1996;26(4):304-9.
1996: Martin den Heijer; T Koster; Henk J Blom; Gerard M J Bos; E Briet; P H Reitsma; J P Vandenbroucke; F R Rosendaal
Hyperhomocysteinemia as a risk factor for deep-vein thrombosis.
The New England journal of medicine 1996;334(12):759-62.
1996: Leo A J Kluijtmans; L P van den Heuvel; Godfried H J Boers; Phyllis Frosst; E M Stevens; BA van Oost; Martin den Heijer; Frans J M Trijbels; Rima Rozen; Henk J Blom
Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.
American journal of human genetics 1996;58(1):35-41.
1995: M G Wouters; M T Moorrees; Marius J van der Mooren; Henk J Blom; G H Boers; L A Schellekens; Chris M G Thomas; Tom K A B Eskes
Plasma homocysteine and menopausal status.
European journal of clinical investigation 1995;25(11):801-5.
1995: N M J van der Put; Régine P M Steegers-Theunissen; Phyllis Frosst; Frans J M Trijbels; Tom K A B Eskes; L P van den Heuvel; Edwin C M Mariman; M den Heyer; Rima Rozen; Henk J Blom
Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida.
Lancet 1995;346(8982):1070-1.
1995: Leo A J Kluijtmans; Henk J Blom; Godfried H J Boers; BA van Oost; Frans J M Trijbels; L P van den Heuvel
Two novel missense mutations in the cystathionine beta-synthase gene in homocystinuric patients.
Human genetics 1995;96(2):249-50.
1995: Régine P M Steegers-Theunissen; G H Boers; Henk J Blom; Jan G Nijhuis; Chris M G Thomas; G F Borm; Tom K A B Eskes
Neural tube defects and elevated homocysteine levels in amniotic fluid.
American journal of obstetrics and gynecology 1995;172(5):1436-41.
1995: Phyllis Frosst; Henk J Blom; R Milos; Philippe Goyette; C A Sheppard; Rowena G Matthews; G J Boers; Martin den Heijer; Leo A J Kluijtmans; L P van den Heuvel
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase.
Nature genetics 1995;10(1):111-3.
1995: Martin den Heijer; Henk J Blom; Wim B J Gerrits; F R Rosendaal; H L Haak; Pierre W Wijermans; Gerard M J Bos
Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis?
Lancet 1995;345(8954):882-5.
1995: M T te Poele-Pothoff; M van den Berg; D G Franken; Godfried H J Boers; C Jakobs; I F de Kroon; Tom K A B Eskes; J M F Trijbels; Henk J Blom
Three different methods for the determination of total homocysteine in plasma.
Annals of clinical biochemistry 1995;32 ( Pt 2)():218-20.
1995: M Van den Berg; Godfried H J Boers; D G Franken; Henk J Blom; G J Van Kamp; C Jakobs; Jan A Rauwerda; Cornelis Kluft; C D Stehouwert
Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease.
European journal of clinical investigation 1995;25(3):176-81.
1995: Henk J Blom; H A Kleinveld; Godfried H J Boers; Pierre N M Demacker; H L Hak-Lemmers; M T Te Poele-Pothoff; J M F Trijbels
Lipid peroxidation and susceptibility of low-density lipoprotein to in vitro oxidation in hyperhomocysteinaemia.
European journal of clinical investigation 1995;25(3):149-54.
1995: A M Engbersen; D G Franken; Godfried H J Boers; E M Stevens; Frans J M Trijbels; Henk J Blom
Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.
American journal of human genetics 1995;56(1):142-50.
1994: Régine P M Steegers-Theunissen; G H Boers; Frans J M Trijbels; J D Finkelstein; Henk J Blom; Chris M G Thomas; G F Borm; M G Wouters; Tom K A B Eskes
Maternal hyperhomocysteinemia: a risk factor for neural-tube defects?
Metabolism: clinical and experimental 1994;43(12):1475-80.
1994: M van den Berg; D G Franken; Godfried H J Boers; Henk J Blom; C Jakobs; C D Stehouwer; Jan A Rauwerda
Combined vitamin B6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia.
Journal of vascular surgery 1994;20(6):933-40.
1994: Marius J van der Mooren; M G Wouters; Henk J Blom; L A Schellekens; Tom K A B Eskes; R Rolland
Hormone replacement therapy may reduce high serum homocysteine in postmenopausal women.
European journal of clinical investigation 1994;24(11):733-6.
1994: D G Franken; Godfried H J Boers; Henk J Blom; Frans J M Trijbels; P W Kloppenborg
Treatment of mild hyperhomocysteinemia in vascular disease patients.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(3):465-70.
1994: D G Franken; Godfried H J Boers; Henk J Blom; J M F Trijbels
Effect of various regimens of vitamin B6 and folic acid on mild hyperhomocysteinaemia in vascular patients.
Journal of inherited metabolic disease 1994;17(1):159-62.
1993: M G Wouters; G H Boers; Henk J Blom; Frans J M Trijbels; Chris M G Thomas; G F Borm; Régine P M Steegers-Theunissen; Tom K A B Eskes
Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss.
Fertility and sterility 1993;60(5):820-5.
1993: D G Franken; A Vreugdenhil; Godfried H J Boers; A Verrips; Henk J Blom; I R Novakova
Familial cerebrovascular accidents due to concomitant hyperhomocysteinemia and protein C deficiency type 1.
Stroke; a journal of cerebral circulation 1993;24(10):1599-600.
1993: Henk J Blom; R A Wevers; A Verrips; M T TePoele-Pothoff; J M F Trijbels
Cerebrospinal fluid homocysteine and the cobalamin status of the brain.
Journal of inherited metabolic disease 1993;16(3):517-9.
1992: Régine P M Steegers-Theunissen; G H Boers; Henk J Blom; Frans J M Trijbels; Tom K A B Eskes
Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae.
Lancet 1992;339(8801):1122-3.
1992: Henk J Blom; A J Davidson; J D Finkelstein; A S Luder; Isa Bernardini; J J Martin; A Tangerman; J M Trijbels; S. Harvey Mudd; Stephen I Goodman
Persistent hypermethioninaemia with dominant inheritance.
Journal of inherited metabolic disease 1992;15(2):188-97.
1992: Henk J Blom; D P Engelen; Godfried H J Boers; A M Stadhouders; Rob C A Sengers; Ronney A De Abreu; M T TePoele-Pothoff; J M F Trijbels
Lipid peroxidation in homocysteinaemia.
Journal of inherited metabolic disease 1992;15(3):419-22.
1991: Henk J Blom; Godfried H J Boers; A Tangerman; William A Gahl; J M F Trijbels
Alternative methionine degradation via the transamination pathway: an option for therapy for homocystinuria due to cystathionine synthase deficiency.
Journal of inherited metabolic disease 1991;14(3):375-8.
1990: Henk J Blom; Hans Andersson; D M Krasnewich; William A Gahl
Pulsed amperometric detection of carbohydrates in lysosomal storage disease fibroblasts: a new screening technique for carbohydrate storage diseases.
Journal of chromatography 1990;533():11-21.
1990: Hans Andersson; L D Kohn; Isa Bernardini; Henk J Blom; F Tietze; William A Gahl
Characterization of lysosomal monoiodotyrosine transport in rat thyroid cells. Evidence for transport by system h.
The Journal of biological chemistry 1990;265(19):10950-4.
1990: Henk J Blom; Hans Andersson; R Seppala; F Tietze; William A Gahl
Defective glucuronic acid transport from lysosomes of infantile free sialic acid storage disease fibroblasts.
The Biochemical journal 1990;268(3):621-5.
1989: Henk J Blom; Godfried H J Boers; J M F Trijbels; J J van Roessel; Albert Tangerman
Cystathionine-synthase-deficient patients do not use the transamination pathway of methionine to reduce hypermethioninemia and homocystinemia.
Metabolism: clinical and experimental 1989;38(6):577-82.
1989: Henk J Blom; Godfried H J Boers; J P van den Elzen; William A Gahl; Albert Tangerman
Transamination of methionine in humans.
Clinical science (London, England : 1979) 1989;76(1):43-9.
1988: Henk J Blom; Godfried H J Boers; J P van den Elzen; J J van Roessel; J M Trijbels; Albert Tangerman
Differences between premenopausal women and young men in the transamination pathway of methionine catabolism, and the protection against vascular disease.
European journal of clinical investigation 1988;18(6):633-8.
1988: Henk J Blom; J P van den Elzen; S H Yap; Albert Tangerman
Methanethiol and dimethylsulfide formation from 3-methylthiopropionate in human and rat hepatocytes.
Biochimica et biophysica acta 1988;972(2):131-6.
1988: William A Gahl; Isa Bernardini; J D Finkelstein; A Tangerman; J J Martin; Henk J Blom; K D Mullen; S. Harvey Mudd
Transsulfuration in an adult with hepatic methionine adenosyltransferase deficiency.
The Journal of clinical investigation 1988;81(2):390-7.