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Charles Sherr

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Chunliang Li; David Finkelstein; Charles J Sherr
Arf tumor suppressor and miR-205 regulate cell adhesion and formation of extraembryonic endoderm from pluripotent stem cells.
Michelle L Churchman; Maria Jasin; Scott Keeney; Ignasi Roig; Charles J Sherr
Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells.
Louise M Treanor; Emmanuel J Volanakis; Sheng Zhou; Taihe Lu; Charles J Sherr; Brian P Sorrentino
Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies.

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All Publications

2013: Chunliang Li; David Finkelstein; Charles J Sherr
Arf tumor suppressor and miR-205 regulate cell adhesion and formation of extraembryonic endoderm from pluripotent stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(12):E1112-21.
2011: Michelle L Churchman; Maria Jasin; Scott Keeney; Ignasi Roig; Charles J Sherr
Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells.
PLoS genetics 2011;7(7):e1002157.
2011: Louise M Treanor; Emmanuel J Volanakis; Sheng Zhou; Taihe Lu; Charles J Sherr; Brian P Sorrentino
Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies.
Blood 2011;117(20):5453-62.
2010: Olivier Ayrault; Haotian Zhao; Frederique Zindy; Chunxu Qu; Charles J Sherr; Martine F Roussel
Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells.
Cancer research 2010;70(13):5618-27.
2009: Adam Gromley; Michelle L Churchman; Frederique Zindy; Charles J Sherr
Transient expression of the Arf tumor suppressor during male germ cell and eye development in Arf-Cre reporter mice.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(15):6285-90.
2009: Olivier Ayrault; Frederique Zindy; Jerold E Rehg; Charles J Sherr; Martine F Roussel
Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma.
Molecular cancer research : MCR 2009;7(1):33-40.
2008: Charles G Mullighan; Richard Williams; James R Downing; Charles J Sherr
Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL.
Genes & development 2008;22(11):1411-5.
2007: Richard Williams; Willem den Besten; Charles J Sherr
Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia.
Genes & development 2007;21(18):2283-7.
2007: Frederique Zindy; Tamar Uziel; Olivier Ayrault; Christopher Calabrese; Marc Valentine; Jerold E Rehg; Richard J Gilbertson; Charles J Sherr; Martine F Roussel
Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors.
Cancer research 2007;67(6):2676-84.
2007: David Bertwistle; Charles J Sherr
Regulation of the Arf tumor suppressor in Emicro-Myc transgenic mice: longitudinal study of Myc-induced lymphomagenesis.
Blood 2007;109(2):792-4.
2007: Richard Williams; Charles J Sherr
The ARF tumor suppressor in acute leukemias: insights from mouse models of Bcr-Abl-induced acute lymphoblastic leukemia.
Advances in experimental medicine and biology 2007;604():107-14.
2006: Charles J Sherr
Divorcing ARF and p53: an unsettled case.
Nature reviews. Cancer 2006;6(9):663-73.
2006: Frederique Zindy; Paul Knoepfler; Suqing Xie; Charles J Sherr; Robert N Eisenman; Martine F Roussel
N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11579-83.
2006: Charles J Sherr
Autophagy by ARF: a short story.
Molecular cell 2006;22(4):436-7.
2006: Richard Williams; Martine F Roussel; Charles J Sherr
Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(17):6688-93.
2006: Willem den Besten; Mei-Ling Kuo; Kenji Tago; Richard Williams; Charles J Sherr
Ubiquitination of, and sumoylation by, the Arf tumor suppressor.
The Israel Medical Association journal : IMAJ 2006;8(4):249-51.
2006: Tamar Uziel; Frederique Zindy; Charles J Sherr; Martine F Roussel
The CDK inhibitor p18Ink4c is a tumor suppressor in medulloblastoma.
Cell cycle (Georgetown, Tex.) 2006;5(4):363-5.
2006: Masataka Sugimoto; Adam Gromley; Charles J Sherr
Hzf, a p53-responsive gene, regulates maintenance of the G2 phase checkpoint induced by DNA damage.
Molecular and cellular biology 2006;26(2):502-12.
2005: Loydie A Jerome-Majewska; Gerard P Jenkins; Elana Ernstoff; Frederique Zindy; Charles J Sherr; Virginia E Papaioannou
Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;234(4):922-33.
2005: Tamar Uziel; Frederique Zindy; Suqing Xie; youngsoo Lee; Antoine Forget; Susan M Magdaleno; Jerold E Rehg; Christopher Calabrese; David J Solecki; Charles G Eberhart; Sarah E Sherr; Sarah Plimmer; Steven C Clifford; Mary E Hatten; Peter J McKinnon; Richard J Gilbertson; Tom Curran; Charles J Sherr; Martine F Roussel
The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation.
Genes & development 2005;19(22):2656-67.
2005: Willem den Besten; Mei-Ling Kuo; Richard Williams; Charles J Sherr
Myeloid leukemia-associated nucleophosmin mutants perturb p53-dependent and independent activities of the Arf tumor suppressor protein.
Cell cycle (Georgetown, Tex.) 2005;4(11):1593-8.
2005: Kenji Tago; Susanna Chiocca; Charles J Sherr
Sumoylation induced by the Arf tumor suppressor: a p53-independent function.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(21):7689-94.
2005: Charles J Sherr; David Bertwistle; Willem den Besten; Mei-Ling Kuo; Masataka Sugimoto; Kenji Tago; Richard Williams; Frederique Zindy; Martine F Roussel
p53-Dependent and -independent functions of the Arf tumor suppressor.
Cold Spring Harbor symposia on quantitative biology 2005;70():129-37.
2004: Charles J Sherr; James M Roberts
Living with or without cyclins and cyclin-dependent kinases.
Genes & development 2004;18(22):2699-711.
2004: Mei-Ling Kuo; Willem den Besten; Charles J Sherr
N-Terminal polyubiquitination of the ARF tumor suppressor, a natural lysine-less protein.
Cell cycle (Georgetown, Tex.) 2004;3(11):1367-9.
2004: David Bertwistle; Frederique Zindy; Charles J Sherr; Martine F Roussel
Monoclonal antibodies to the mouse p19(Arf) tumor suppressor protein.
Hybridoma and hybridomics 2004;23(5):293-300.
2004: John L Cleveland; Charles J Sherr
Antagonism of Myc functions by Arf.
Cancer cell 2004;6(4):309-11.
2004: Mei-Ling Kuo; Willem den Besten; David Bertwistle; Martine F Roussel; Charles J Sherr
N-terminal polyubiquitination and degradation of the Arf tumor suppressor.
Genes & development 2004;18(15):1862-74.
2004: Charles J Sherr
An Arf(GFP/GFP) reporter mouse reveals that the Arf tumor suppressor monitors latent oncogenic signals in vivo.
Cell cycle (Georgetown, Tex.) 2004;3(3):239-40.
2004: David Bertwistle; Masataka Sugimoto; Charles J Sherr
Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23.
Molecular and cellular biology 2004;24(3):985-96.
2004: Charles J Sherr
Principles of tumor suppression.
Cell 2004;116(2):235-46.
2003: Frederique Zindy; Richard Williams; Troy A Baudino; Jerold E Rehg; Stephen Xavier Skapek; John L Cleveland; Martine F Roussel; Charles J Sherr
Arf tumor suppressor promoter monitors latent oncogenic signals in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15930-5.
2003: Frederique Zindy; Lisa M Nilsson; Luc Nguyen; Cecile Meunier; Richard J Smeyne; Jerold E Rehg; Charles G Eberhart; Charles J Sherr; Martine F Roussel
Hemangiosarcomas, medulloblastomas, and other tumors in Ink4c/p53-null mice.
Cancer research 2003;63(17):5420-7.
2003: Troy A Baudino; Kirsteen H Maclean; Jennifer Brennan; Evan Parganas; Chunying Yang; Aaron S. Aslanian; Jacqueline A Lees; Charles J Sherr; Martine F Roussel; John L Cleveland
Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss.
Molecular cell 2003;11(4):905-14.
2003: Mei-Ling Kuo; Eric J Duncavage; Rose Mathew; Willem den Besten; Deqing Pei; Deanna Naeve; Tadashi Yamamoto; Cheng Cheng; Charles J Sherr; Martine F Roussel
Arf induces p53-dependent and -independent antiproliferative genes.
Cancer research 2003;63(5):1046-53.
2003: Masataka Sugimoto; Mei-Ling Kuo; Martine F Roussel; Charles J Sherr
Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing.
Molecular cell 2003;11(2):415-24.
2003: Scott W Lowe; Charles J Sherr
Tumor suppression by Ink4a-Arf: progress and puzzles.
Current opinion in genetics & development 2003;13(1):77-83.
2002: Charles J Sherr; Frank McCormick
The RB and p53 pathways in cancer.
Cancer cell 2002;2(2):103-12.
2002: Jinjun Dang; Mei-Ling Kuo; Christine M Eischen; Lilia Stepanova; Charles J Sherr; Martine F Roussel
The RING domain of Mdm2 can inhibit cell proliferation.
Cancer research 2002;62(4):1222-30.
2001: K Inoue; Frederique Zindy; DH Randle; Jerold E Rehg; Charles J Sherr
Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas.
Genes & development 2001;15(22):2934-9.
2001: Charles J Sherr
The INK4a/ARF network in tumour suppression.
Nature reviews. Molecular cell biology 2001;2(10):731-7.
2001: Charles J Sherr
Parsing Ink4a/Arf: "pure" p16-null mice.
Cell 2001;106(5):531-4.
2001: DH Randle; Frederique Zindy; Charles J Sherr; Martine F Roussel
Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9654-9.
2001: Frederique Zindy; Willem den Besten; B Chen; Jerold E Rehg; E Latres; Mariano Barbacid; Jeffrey W Pollard; Charles J Sherr; Paula E Cohen; Martine F Roussel
Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors p18(Ink4c) and p19(Ink4d).
Molecular and cellular biology 2001;21(9):3244-55.
2000: Jason D. Weber; John R Jeffers; Jerold E Rehg; DH Randle; G Lozano; Martine F Roussel; Charles J Sherr; Gerard P Zambetti
p53-independent functions of the p19(ARF) tumor suppressor.
Genes & development 2000;14(18):2358-65.
2000: Anja Groth; Jason D. Weber; Berthe M Willumsen; Charles J Sherr; Martine F Roussel
Oncogenic Ras induces p19ARF and growth arrest in mouse embryo fibroblasts lacking p21Cip1 and p27Kip1 without activating cyclin D-dependent kinases.
The Journal of biological chemistry 2000;275(35):27473-80.
2000: Charles J Sherr; Ronald A DePinho
Cellular senescence: mitotic clock or culture shock?
Cell 2000;102(4):407-10.
2000: Charles J Sherr
The Pezcoller lecture: cancer cell cycles revisited.
Cancer research 2000;60(14):3689-95.
2000: K Inoue; R Wen; Jerold E Rehg; M Adachi; John L Cleveland; Martine F Roussel; Charles J Sherr
Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis.
Genes & development 2000;14(14):1797-809.
2000: Jason D. Weber; Mei-Ling Kuo; Brian Bothner; Enrico L DiGiammarino; Richard W Kriwacki; Martine F Roussel; Charles J Sherr
Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.
Molecular and cellular biology 2000;20(7):2517-28.
2000: Charles J Sherr; Jason D. Weber
The ARF/p53 pathway.
Current opinion in genetics & development 2000;10(1):94-9.
2000: Charles J Sherr
Cell cycle control and cancer.
Harvey lectures 2000;96():73-92.
2000: Frederique Zindy; Jan M A van Deursen; Gerard C Grosveld; Charles J Sherr; Martine F Roussel
INK4d-deficient mice are fertile despite testicular atrophy.
Molecular and cellular biology 2000;20(1):372-8.
1999: Frederique Zindy; Justine J Cunningham; Charles J Sherr; S Jogal; Richard J Smeyne; Martine F Roussel
Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13462-7.
1999: Christine M Eischen; Jason D. Weber; Martine F Roussel; Charles J Sherr; John L Cleveland
Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis.
Genes & development 1999;13(20):2658-69.
1999: Joseph W Brewer; Linda M Hendershot; Charles J Sherr; J Alan Diehl
Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8505-10.
1999: Charles J Sherr; J M Roberts
CDK inhibitors: positive and negative regulators of G1-phase progression.
Genes & development 1999;13(12):1501-12.
1999: T Kamijo; E van de Kamp; Miriam J Chong; Frederique Zindy; J Alan Diehl; Charles J Sherr; Peter J McKinnon
Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function.
Cancer research 1999;59(10):2464-9.
1999: Jason D. Weber; Laura J Taylor; Martine F Roussel; Charles J Sherr; Dafna Bar-Sagi
Nucleolar Arf sequesters Mdm2 and activates p53.
Nature cell biology 1999;1(1):20-6.
1999: T Kamijo; S Bodner; E van de Kamp; DH Randle; Charles J Sherr
Tumor spectrum in ARF-deficient mice.
Cancer research 1999;59(9):2217-22.
1999: K Inoue; Martine F Roussel; Charles J Sherr
Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3993-8.
1999: M Cheng; P Olivier; J Alan Diehl; M Fero; Martine F Roussel; J M Roberts; Charles J Sherr
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts.
The EMBO journal 1999;18(6):1571-83.
1999: Veronika Sexl; J Alan Diehl; Charles J Sherr; RA Ashmun; D Beach; Martine F Roussel
A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2.
Oncogene 1999;18(3):573-82.
1998: J Alan Diehl; M Cheng; Martine F Roussel; Charles J Sherr
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
Genes & development 1998;12(22):3499-511.
1998: K Inoue; Charles J Sherr; Linda H. Shapiro
Regulation of the CD13/aminopeptidase N gene by DMP1, a transcription factor antagonized by D-type cyclins.
The Journal of biological chemistry 1998;273(44):29188-94.
1998: Charles J Sherr
Tumor surveillance via the ARF-p53 pathway.
Genes & development 1998;12(19):2984-91.
1998: Elisa de Stanchina; Mila E McCurrach; Frederique Zindy; S Y Shieh; Gerardo Ferbeyre; Andrew V Samuelson; Carol Prives; Martine F Roussel; Charles J Sherr; Scott W Lowe
E1A signaling to p53 involves the p19(ARF) tumor suppressor.
Genes & development 1998;12(15):2434-42.
1998: Frederique Zindy; Christine M Eischen; DH Randle; T Kamijo; John L Cleveland; Charles J Sherr; Martine F Roussel
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.
Genes & development 1998;12(15):2424-33.
1998: T Kamijo; Jason D. Weber; Gerard P Zambetti; Frederique Zindy; Martine F Roussel; Charles J Sherr
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):8292-7.
1998: K Inoue; Charles J Sherr
Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase-independent mechanism.
Molecular and cellular biology 1998;18(3):1590-600.
1998: M Cheng; Veronika Sexl; Charles J Sherr; Martine F Roussel
Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1).
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):1091-6.
1997: J Alan Diehl; Charles J Sherr
A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase.
Molecular and cellular biology 1997;17(12):7362-74.
1997: T Kamijo; Frederique Zindy; Martine F Roussel; Dawn E Quelle; James R Downing; RA Ashmun; Gerard C Grosveld; Charles J Sherr
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.
Cell 1997;91(5):649-59.
1997: Frederique Zindy; H Soares; K H Herzog; J Morgan; Charles J Sherr; Martine F Roussel
Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(11):1139-50.
1997: Frederique Zindy; Dawn E Quelle; Martine F Roussel; Charles J Sherr
Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.
Oncogene 1997;15(2):203-11.
1997: J Alan Diehl; Frederique Zindy; Charles J Sherr
Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway.
Genes & development 1997;11(8):957-72.
1997: Dawn E Quelle; M Cheng; RA Ashmun; Charles J Sherr
Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):669-73.
1996: Charles J Sherr
Cancer cell cycles.
Science (New York, N.Y.) 1996;274(5293):1672-7.
1996: H Hirai; Charles J Sherr
Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1.
Molecular and cellular biology 1996;16(11):6457-67.
1996: Martine F Roussel; RA Ashmun; Charles J Sherr; Robert N Eisenman; Donald E Ayer
Inhibition of cell proliferation by the Mad1 transcriptional repressor.
Molecular and cellular biology 1996;16(6):2796-801.
1995: Dawn E Quelle; Frederique Zindy; RA Ashmun; Charles J Sherr
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.
Cell 1995;83(6):993-1000.
1995: T Okuda; H Hirai; Virginia Valentine; Sheila A Shurtleff; Vincent J Kidd; Jill Lahti; Charles J Sherr; James R Downing
Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases.
Genomics 1995;29(3):623-30.
1995: Dawn E Quelle; RA Ashmun; G J Hannon; P A Rehberger; D Trono; Karl Hartmut Richter; C Walker; D Beach; Charles J Sherr; M Serrano
Cloning and characterization of murine p16INK4a and p15INK4b genes.
Oncogene 1995;11(4):635-45.
1995: Martine F Roussel; A M Theodoras; M Pagano; Charles J Sherr
Rescue of defective mitogenic signaling by D-type cyclins.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):6837-41.
1995: Charles J Sherr; J M Roberts
Inhibitors of mammalian G1 cyclin-dependent kinases.
Genes & development 1995;9(10):1149-63.
1995: H Hirai; Martine F Roussel; J Y Kato; RA Ashmun; Charles J Sherr
Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.
Molecular and cellular biology 1995;15(5):2672-81.
1995: T Okuda; Sheila A Shurtleff; M B Valentine; Susana C Raimondi; D R Head; Frederick G. Behm; A M Curcio-Brint; Q Liu; Ching-Hon Pui; Charles J Sherr
Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia.
Blood 1995;85(9):2321-30.
1994: Charles J Sherr
G1 phase progression: cycling on cue.
Cell 1994;79(4):551-5.
1994: J Y Kato; M Matsuoka; Kornelia Polyak; Joan Massagué; Charles J Sherr
Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.
Cell 1994;79(3):487-96.
1994: M Matsuoka; J Y Kato; Robert P Fisher; D O Morgan; Charles J Sherr
Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase.
Molecular and cellular biology 1994;14(11):7265-75.
1994: J Y Kato; M Matsuoka; DK Strom; Charles J Sherr
Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.
Molecular and cellular biology 1994;14(4):2713-21.
1994: H Matsushime; Dawn E Quelle; Sheila A Shurtleff; M Shibuya; Charles J Sherr; J Y Kato
D-type cyclin-dependent kinase activity in mammalian cells.
Molecular and cellular biology 1994;14(3):2066-76.
1994: S J Vallance; H M Lee; Martine F Roussel; Sheila A Shurtleff; J Y Kato; DK Strom; Charles J Sherr
Monoclonal antibodies to mammalian D-type G1 cyclins.
Hybridoma 1994;13(1):37-44.
1994: Kornelia Polyak; J Y Kato; M J Solomon; Charles J Sherr; J Massague; James M Roberts; Andrew Koff
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
Genes & development 1994;8(1):9-22.
1994: Charles J Sherr; J Kato; Dawn E Quelle; M Matsuoka; Martine F Roussel
D-type cyclins and their cyclin-dependent kinases: G1 phase integrators of the mitogenic response.
Cold Spring Harbor symposia on quantitative biology 1994;59():11-9.
1993: J Y Kato; Charles J Sherr
Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11513-7.
1993: Z A Khatib; H Matsushime; M Valentine; DN Shapiro; Charles J Sherr; A Thomas Look
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas.
Cancer research 1993;53(22):5535-41.
1993: Dawn E Quelle; RA Ashmun; Sheila A Shurtleff; J Y Kato; D Bar-Sagi; Martine F Roussel; Charles J Sherr
Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.
Genes & development 1993;7(8):1559-71.
1993: Charles J Sherr
Mammalian G1 cyclins.
Cell 1993;73(6):1059-65.
1993: Mark E Ewen; H K Sluss; Charles J Sherr; H Matsushime; J Kato; David M Livingston
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins.
Cell 1993;73(3):487-97.
1993: J Kato; H Matsushime; Scott W Hiebert; Mark E Ewen; Charles J Sherr
Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4.
Genes & development 1993;7(3):331-42.
1992: H Matsushime; Mark E Ewen; DK Strom; J Y Kato; S K Hanks; Martine F Roussel; Charles J Sherr
Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins.
Cell 1992;71(2):323-34.
1992: Toshiya Inaba; H Matsushime; M Valentine; Martine F Roussel; Charles J Sherr; A Thomas Look
Genomic organization, chromosomal localization, and independent expression of human cyclin D genes.
Genomics 1992;13(3):565-74.
1992: T van Daalen Wetters; S A Hawkins; Martine F Roussel; Charles J Sherr
Random mutagenesis of CSF-1 receptor (FMS) reveals multiple sites for activating mutations within the extracellular domain.
The EMBO journal 1992;11(2):551-7.
1992: Charles J Sherr; H Matsushime; Martine F Roussel
Regulation of CYL/cyclin D genes by colony-stimulating factor 1.
Ciba Foundation symposium 1992;170():209-19; discussion 219-26.
1991: Charles J Sherr
Mitogenic response to colony-stimulating factor 1.
Trends in genetics : TIG 1991;7(11-12):398-402.
1991: Martine F Roussel; John L Cleveland; Sheila A Shurtleff; Charles J Sherr
Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling.
Nature 1991;353(6342):361-3.
1991: H Matsushime; Martine F Roussel; K Matsushima; A Hishinuma; Charles J Sherr
Cloning and expression of murine interleukin-1 receptor antagonist in macrophages stimulated by colony-stimulating factor 1.
Blood 1991;78(3):616-23.
1991: H Matsushime; Martine F Roussel; RA Ashmun; Charles J Sherr
Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle.
Cell 1991;65(4):701-13.
1991: J Kato; Charles J Sherr
A dominant suppressive mutation in a cellular gene restores the nontransformed phenotype to v-fms-transformed mink cells.
Oncogene 1991;6(5):687-93.
1991: James R Downing; Sheila A Shurtleff; Charles J Sherr
Peptide antisera to human colony-stimulating factor 1 receptor detect ligand-induced conformational changes and a binding site for phosphatidylinositol 3-kinase.
Molecular and cellular biology 1991;11(5):2489-95.
1991: Charles J Sherr; G V Borzillo; J Kato; Sheila A Shurtleff; James R Downing; Martine F Roussel
Regulation of cell growth and differentiation by the colony-stimulating factor 1 receptor.
Seminars in hematology 1991;28(2):143-51.
1991: H Matsushime; Martine F Roussel; Charles J Sherr
Novel mammalian cyclins (CYL genes) expressed during G1.
Cold Spring Harbor symposia on quantitative biology 1991;56():69-74.
1990: Martine F Roussel; Sheila A Shurtleff; James R Downing; Charles J Sherr
A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6738-42.
1990: Sheila A Shurtleff; James R Downing; C O Rock; S A Hawkins; Martine F Roussel; Charles J Sherr
Structural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinase.
The EMBO journal 1990;9(8):2415-21.
1990: G V Borzillo; RA Ashmun; Charles J Sherr
Macrophage lineage switching of murine early pre-B lymphoid cells expressing transduced fms genes.
Molecular and cellular biology 1990;10(6):2703-14.
1990: J Kato; Charles J Sherr
Human colony-stimulating factor 1 (CSF-1) receptor confers CSF-1 responsiveness to interleukin-3-dependent 32DC13 mouse myeloid cells and abrogates differentiation in response to granulocyte CSF.
Blood 1990;75(9):1780-7.
1990: Martine F Roussel; Catherine transy; J Y Kato; Ellis L Reinherz; Charles J Sherr
Antibody-induced mitogenicity mediated by a chimeric CD2-c-fms receptor.
Molecular and cellular biology 1990;10(5):2407-12.
1990: M Ohtsuka; Martine F Roussel; Charles J Sherr; James R Downing
Ligand-induced phosphorylation of the colony-stimulating factor 1 receptor can occur through an intermolecular reaction that triggers receptor down modulation.
Molecular and cellular biology 1990;10(4):1664-71.
1990: Charles J Sherr
Regulation of mononuclear phagocyte proliferation by colony-stimulating factor-1.
International journal of cell cloning 1990;8 Suppl 1():46-60; discussion 60-2.
1990: Martine F Roussel; J R Downing; Charles J Sherr
Transforming activities of human CSF-1 receptors with different point mutations at codon 301 in their extracellular domains.
Oncogene 1990;5(1):25-30.
1990: Charles J Sherr; J Y Kato; G Borzillo; James R Downing; Martine F Roussel
Signal-response coupling mediated by the transduced colony-stimulating factor-1 receptor and its oncogenic fms variants in naive cells.
Ciba Foundation symposium 1990;148():96-104; discussion 104-9.
1990: Charles J Sherr
Colony-stimulating factor-1 receptor.
Blood 1990;75(1):1-12.
1990: Charles J Sherr
The colony-stimulating factor 1 receptor: pleiotropy of signal-response coupling.
Lymphokine research 1990;9(4):543-8.
1989: J R Downing; Benjamin L Margolis; A Zilberstein; R A Ashmun; A Ullrich; Charles J Sherr; J Schlessinger
Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1.
The EMBO journal 1989;8(11):3345-50.
1989: Martine F Roussel; Charles J Sherr
Mouse NIH 3T3 cells expressing human colony-stimulating factor 1 (CSF-1) receptors overgrow in serum-free medium containing human CSF-1 as their only growth factor.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7924-7.
1989: G V Borzillo; Charles J Sherr
Early pre-B-cell transformation induced by the v-fms oncogene in long-term mouse bone marrow cultures.
Molecular and cellular biology 1989;9(9):3973-81.
1989: C W Rettenmier; Charles J Sherr
The mononuclear phagocyte colony-stimulating factor (CSF-1, M-CSF).
Hematology/oncology clinics of North America 1989;3(3):479-93.
1989: J Y Kato; M F Roussel; RA Ashmun; Charles J Sherr
Transduction of human colony-stimulating factor-1 (CSF-1) receptor into interleukin-3-dependent mouse myeloid cells induces both CSF-1-dependent and factor-independent growth.
Molecular and cellular biology 1989;9(9):4069-73.
1989: RA Ashmun; A Thomas Look; W M Roberts; Martine F Roussel; S Seremetis; M Ohtsuka; Charles J Sherr
Monoclonal antibodies to the human CSF-1 receptor (c-fms proto-oncogene product) detect epitopes on normal mononuclear phagocytes and on human myeloid leukemic blast cells.
Blood 1989;73(3):827-37.
1988: Martine F Roussel; James R Downing; C W Rettenmier; Charles J Sherr
A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential.
Cell 1988;55(6):979-88.
1988: Charles J Sherr
The role of the CSF-1 receptor gene (C-fms) in cell transformation.
Leukemia 1988;2(12 Suppl):132S-142S.
1988: W M Roberts; A Thomas Look; Martine F Roussel; Charles J Sherr
Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes.
Cell 1988;55(4):655-61.
1988: Charles J Sherr; Martine F Roussel; C W Rettenmier
Colony-stimulating factor-1 receptor (c-fms).
Journal of cellular biochemistry 1988;38(3):179-87.
1988: Martine F Roussel; James R Downing; RA Ashmun; C W Rettenmier; Charles J Sherr
Colony-stimulating factor 1-mediated regulation of a chimeric c-fms/v-fms receptor containing the v-fms-encoded tyrosine kinase domain.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):5903-7.
1988: Martine F Roussel; C W Rettenmier; Charles J Sherr
Introduction of a human colony stimulating factor-1 gene into a mouse macrophage cell line induces CSF-1 independence but not tumorigenicity.
Blood 1988;71(5):1218-25.
1988: James R Downing; C W Rettenmier; Charles J Sherr
Ligand-induced tyrosine kinase activity of the colony-stimulating factor 1 receptor in a murine macrophage cell line.
Molecular and cellular biology 1988;8(4):1795-9.
1988: C W Rettenmier; Martine F Roussel; Charles J Sherr
The colony-stimulating factor 1 (CSF-1) receptor (c-fms proto-oncogene product) and its ligand.
Journal of cell science. Supplement 1988;9():27-44.
1988: Charles J Sherr; C W Rettenmier; Martine F Roussel
Macrophage colony-stimulating factor, CSF-1, and its proto-oncogene-encoded receptor.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():521-30.
1987: J M Heard; Martine F Roussel; C W Rettenmier; Charles J Sherr
Multilineage hematopoietic disorders induced by transplantation of bone marrow cells expressing the v-fms oncogene.
Cell 1987;51(4):663-73.
1987: J M Heard; Martine F Roussel; C W Rettenmier; Charles J Sherr
Synthesis, post-translational processing, and autocrine transforming activity of a carboxylterminal truncated form of colony stimulating factor-1.
Oncogene research 1987;1(4):423-40.
1987: C W Rettenmier; Martine F Roussel; RA Ashmun; P Ralph; K Price; Charles J Sherr
Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes.
Molecular and cellular biology 1987;7(7):2378-87.
1987: Charles J Sherr
Fibroblast and hematopoietic cell transformation by the fms oncogene (CSF-1 receptor).
Journal of cellular physiology. Supplement 1987;Suppl 5():83-7.
1986: E F Wheeler; C W Rettenmier; A T Look; Charles J Sherr
The v-fms oncogene induces factor independence and tumorigenicity in CSF-1 dependent macrophage cell line.
Nature 1986;324(6095):377-80.
1986: E F Wheeler; Martine F Roussel; A Hampe; M H Walker; V A Fried; A T Look; C W Rettenmier; Charles J Sherr
The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences.
Journal of virology 1986;59(2):224-33.
1986: C W Rettenmier; Martine F Roussel; E F Wheeler; Charles J Sherr
Requirements for transformation by the fms oncogene product (CSF-1 receptor).
Princess Takamatsu symposia 1986;17():211-8.