FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Ethan Shevach

Research Profile

Living Beings

Anatomy

Physiology

Chemicals & Drugs

Disorders

Concepts & Ideas

T-Lymphocyte Subsets

Co-author Network

Publications

TOP 3
Abul K Abbas; Christophe Benoist; Jeffrey A Bluestone; Daniel J Campbell; Sankar Ghosh; Shohei Hori; Shuiping Jiang; Vijay K Kuchroo; Diane Mathis; Maria Grazia Roncarolo; Alexander Rudensky; Shimon Sakaguchi; Ethan M Shevach; Dario A A Vignali; Steve F Ziegler
Regulatory T cells: recommendations to simplify the nomenclature.
Michael G Strainic; Ethan M Shevach; Fengqi An; Feng Lin; M Edward Medof
Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.
Ethan M Shevach
Application of IL-2 therapy to target T regulatory cell function.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Ethan Shevach (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Abul K Abbas; Christophe Benoist; Jeffrey A Bluestone; Daniel J Campbell; Sankar Ghosh; Shohei Hori; Shuiping Jiang; Vijay K Kuchroo; Diane Mathis; Maria Grazia Roncarolo; Alexander Rudensky; Shimon Sakaguchi; Ethan M Shevach; Dario A A Vignali; Steve F Ziegler
Regulatory T cells: recommendations to simplify the nomenclature.
Nature immunology 2013;14(4):307-8.
2013: Michael G Strainic; Ethan M Shevach; Fengqi An; Feng Lin; M Edward Medof
Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.
Nature immunology 2013;14(2):162-71.
2012: Ethan M Shevach
Application of IL-2 therapy to target T regulatory cell function.
Trends in immunology 2012;33(12):626-32.
2012: Yong Chan Kim; Ravikiran Bhairavabhotla; Amit Golding; Angela M Thornton; Dat Q Tran; Jeongheon Yoon; Ethan M Shevach
Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion.
Blood 2012;119(12):2810-8.
2011: Yongge Zhao; Ivan J Fuss; Matthew C Kinney; Chi A Ma; Ethan M Shevach; Jacob J Spinner; Angela M Thornton; Ashish Jain
The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor β (TGF-β) signaling and the development of regulatory T cells.
The Journal of biological chemistry 2011;286(47):40520-30.
2011: Ruslan Medzhitov; Andrew L Mellor; David H Munn; Chen Dong; Leona Gabryšová; Dmitry Gabrilovich; Siamon Gordon; Göran K Hansson; Ashleigh Howes; Peter Libby; Ethan M Shevach; Ken Shortman; Giorgio Trinchieri; Anne O'Garra
Highlights of 10 years of immunology in Nature Reviews Immunology.
Nature reviews. Immunology 2011;11(10):693-702.
2011: Todd S Davidson; Ethan M Shevach
Polyclonal Treg cells modulate T effector cell trafficking.
European journal of immunology 2011;41(10):2862-70.
2011: Justin R Killebrew; Alan Kwan; Nikole Perdue; Ethan M Shevach; Angela M Thornton; Daniel J Campbell
A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(2):861-9.
2011: Qian Chen; Yong Chan Kim; Arian Dominic John laurence; George A Punkosdy; Ethan M Shevach
IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(11):6329-37.
2011: Ethan M Shevach
The resurrection of T cell-mediated suppression.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):3805-7.
2011: George A Punkosdy; Melissa Blain; Deborah D Glass; Mary M Lozano; Leigh O'Mara; Jaquelin P Dudley; Rafi Ahmed; Ethan M Shevach
Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(9):3677-82.
2011: Ethan M Shevach
Biological functions of regulatory T cells.
Advances in immunology 2011;112():137-76.
2010: Kamran Ghoreschi; Arian Dominic John laurence; Xiang-Ping Yang; Cristina M Tato; Mandy J McGeachy; Joanne E Konkel; Haydeé L Ramos; Lai Wei; Todd S Davidson; Nicolas Bouladoux; John R Grainger; Qian Chen; Yuka Kanno; Wendy T Watford; Hong-Wei Sun; Gérard Eberl; Ethan M Shevach; Yasmine Belkaid; Daniel J Cua; Wanjun Chen; John O'Shea
Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling.
Nature 2010;467(7318):967-71.
2010: Silvia Vendetti; Todd S Davidson; Filippo Veglia; Antonella Riccomi; Donatella Rm Negri; Ragnar Lindstedt; Paolo Pasquali; Ethan M Shevach; Maria Teresa De Magistris
Polyclonal Treg cells enhance the activity of a mucosal adjuvant.
Immunology and cell biology 2010;88(7):698-706.
2010: Yong Chan Kim; Kee Kwang Kim; Ethan M Shevach
Simvastatin induces Foxp3+ T regulatory cells by modulation of transforming growth factor-beta signal transduction.
Immunology 2010;130(4):484-93.
2010: Ethan M Shevach
TGF-Beta to the rescue.
Immunity 2010;32(5):585-7.
2010: Eva N Huter; Kannan Natarajan; Troy R Torgerson; Deborah D Glass; Ethan M Shevach
Autoantibodies in scurfy mice and IPEX patients recognize keratin 14.
The Journal of investigative dermatology 2010;130(5):1391-9.
2010: Angela M Thornton; Patricia E Korty; Dat Q Tran; Elizabeth A Wohlfert; Patrick E Murray; Yasmine Belkaid; Ethan M Shevach
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):3433-41.
2010: Paolo Pasquali; Angela M Thornton; Silvia Vendetti; Claudia Pistoia; Paola Petrucci; Michela Tarantino; Michele Pesciaroli; Franco Ruggeri; Andrea Battistoni; Ethan M Shevach
CD4+CD25+ T regulatory cells limit effector T cells and favor the progression of brucellosis in BALB/c mice.
Microbes and infection / Institut Pasteur 2010;12(1):3-10.
2009: Qian Chen; Todd S Davidson; Eva N Huter; Ethan M Shevach
Engagement of TLR2 does not reverse the suppressor function of mouse regulatory T cells, but promotes their survival.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(7):4458-66.
2009: Dat Q Tran; John Andersson; Rui Wang; Heather Ramsey; Derya Unutmaz; Ethan M Shevach
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13445-50.
2009: Dat Q Tran; John Andersson; Donna Hardwick; Lolita Bebris; Gabor G Illei; Ethan M Shevach
Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures.
Blood 2009;113(21):5125-33.
2009: Eva N Huter; Georg H Stummvoll; Richard DiPaolo; Deborah D Glass; Ethan M Shevach
Pre-differentiated Th1 and Th17 effector T cells in autoimmune gastritis: Ag-specific regulatory T cells are more potent suppressors than polyclonal regulatory T cells.
International immunopharmacology 2009;9(5):540-5.
2009: Ethan M Shevach
Mechanisms of foxp3+ T regulatory cell-mediated suppression.
Immunity 2009;30(5):636-45.
2009: Dat Q Tran; Ethan M Shevach
Therapeutic potential of FOXP3(+) regulatory T cells and their interactions with dendritic cells.
Human immunology 2009;70(5):294-9.
2009: Dat Q Tran; Deborah D Glass; Gulbu Uzel; Dirk A Darnell; Christine Spalding; Steven M Holland; Ethan M Shevach
Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):2929-38.
2009: Jinfang Zhu; Todd S Davidson; Gang Wei; Dragana Jankovic; Kairong Cui; Dustin E Schones; Liying Guo; Keji Zhao; Ethan M Shevach; William Paul
Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells.
The Journal of experimental medicine 2009;206(2):329-41.
2009: Richard DiPaolo; Ethan M Shevach
CD4+ T-cell development in a mouse expressing a transgenic TCR derived from a Treg.
European journal of immunology 2009;39(1):234-40.
2008: Eva N Huter; Georg H Stummvoll; Richard DiPaolo; Deborah D Glass; Ethan M Shevach
Cutting edge: antigen-specific TGF beta-induced regulatory T cells suppress Th17-mediated autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8209-13.
2008: Ditza Levin; Richard DiPaolo; Carine Brinster; Maria Jamela R Revilleza; Lisa F Boyd; Luc Teyton; Kannan Natarajan; Michael G Mage; Ethan M Shevach; David Margulies
Availability of autoantigenic epitopes controls phenotype, severity, and penetrance in TCR Tg autoimmune gastritis.
European journal of immunology 2008;38(12):3339-53.
2008: Ethan M Shevach; Todd S Davidson; Eva N Huter; Richard DiPaolo; John Andersson
Role of TGF-Beta in the induction of Foxp3 expression and T regulatory cell function.
Journal of clinical immunology 2008;28(6):640-6.
2008: Ethan M Shevach
Immunology. Regulating suppression.
Science (New York, N.Y.) 2008;322(5899):202-3.
2008: Marko Pesu; Wendy T Watford; Lai Wei; Lili Xu; Ivan J Fuss; Warren Strober; John Andersson; Ethan M Shevach; Martha Quezado; Nicolas Bouladoux; Anton Roebroek; Yasmine Belkaid; John Creemers; John O'Shea
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Nature 2008;455(7210):246-50.
2008: John Andersson; Dat Q Tran; Marko Pesu; Todd S Davidson; Heather Ramsey; John O'Shea; Ethan M Shevach
CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner.
The Journal of experimental medicine 2008;205(9):1975-81.
2008: Georg H Stummvoll; Richard DiPaolo; Eva N Huter; Todd S Davidson; Deborah Glass; Jerrold M Ward; Ethan M Shevach
Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):1908-16.
2008: Carine Brinster; Ethan M Shevach
Costimulatory effects of IL-1 on the expansion/differentiation of CD4+CD25+Foxp3+ and CD4+CD25+Foxp3- T cells.
Journal of leukocyte biology 2008;84(2):480-7.
2008: Françoise Meylan; Todd S Davidson; Erin Kahle; Michelle Kinder; Krishika Acharya; Dragana Jankovic; Virgilio Bundoc; Marcus Hodges; Ethan M Shevach; Andrea Keane-Myers; Eddie C Y Wang; Richard Siegel
The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases.
Immunity 2008;29(1):79-89.
2008: Eva N Huter; George A Punkosdy; Deborah D Glass; Lily I Cheng; Jerrold M Ward; Ethan M Shevach
TGF-beta-induced Foxp3+ regulatory T cells rescue scurfy mice.
European journal of immunology 2008;38(7):1814-21.
2008: Ethan M Shevach; Dat Q Tran; Todd S Davidson; John Andersson
The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function.
European journal of immunology 2008;38(4):915-7.
2008: Kevin M Elias; Arian Dominic John laurence; Todd S Davidson; Geoffrey Stephens; Yuka Kanno; Ethan M Shevach; John O'Shea
Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway.
Blood 2008;111(3):1013-20.
2008: Ethan M Shevach
Special regulatory T cell review: How I became a T suppressor/regulatory cell maven.
Immunology 2008;123(1):3-5.
2007: Dat Q Tran; Heather Ramsey; Ethan M Shevach
Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype.
Blood 2007;110(8):2983-90.
2007: Richard DiPaolo; Carine Brinster; Todd S Davidson; John Andersson; Deborah Glass; Ethan M Shevach
Autoantigen-specific TGFbeta-induced Foxp3+ regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4685-93.
2007: Geoffrey L Stephens; Ethan M Shevach
Foxp3+ regulatory T cells: selfishness under scrutiny.
Immunity 2007;27(3):417-9.
2007: Jeffrey A Bluestone; Angus W Thomson; Ethan M Shevach; Howard L Weiner
What does the future hold for cell-based tolerogenic therapy?
Nature reviews. Immunology 2007;7(8):650-4.
2007: Geoffrey L Stephens; John Andersson; Ethan M Shevach
Distinct subsets of FoxP3+ regulatory T cells participate in the control of immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):6901-11.
2007: Zhengju Yao; Yuka Kanno; Marc Kerenyi; Geoffrey Stephens; Lydia Durant; Wendy T Watford; Arian Dominic John laurence; Gertraud W Robinson; Ethan M Shevach; Richard Moriggl; Lothar Hennighausen; Changyou Wu; John O'Shea
Nonredundant roles for Stat5a/b in directly regulating Foxp3.
Blood 2007;109(10):4368-75.
2007: Todd S Davidson; Richard DiPaolo; John Andersson; Ethan M Shevach
Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4022-6.
2007: John Andersson; Irena Stefanova; Geoffrey L Stephens; Ethan M Shevach
CD4+CD25+ regulatory T cells are activated in vivo by recognition of self.
International immunology 2007;19(4):557-66.
2007: Miao Qiao; Angela M Thornton; Ethan M Shevach
CD4+ CD25+ [corrected] regulatory T cells render naive CD4+ CD25- T cells anergic and suppressive.
Immunology 2007;120(4):447-55.
2007: Arian Dominic John laurence; Cristina M Tato; Todd S Davidson; Yuka Kanno; Zhi Chen; Zhengju Yao; Rebecca B Blank; Françoise Meylan; Richard Siegel; Lothar Hennighausen; Ethan M Shevach; John O'Shea
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.
Immunity 2007;26(3):371-81.
2006: Ekaterina Yurchenko; Michael Tritt; Valerie Hay; Ethan M Shevach; Yasmine Belkaid; Ciriaco Piccirillo
CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence.
The Journal of experimental medicine 2006;203(11):2451-60.
2006: Ethan M Shevach
From vanilla to 28 flavors: multiple varieties of T regulatory cells.
Immunity 2006;25(2):195-201.
2006: Ethan M Shevach; Richard DiPaolo; John Andersson; Dong-Mei Zhao; Geoffrey L Stephens; Angela M Thornton
The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells.
Immunological reviews 2006;212():60-73.
2006: Ethan M Shevach; Geoffrey L Stephens
The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity?
Nature reviews. Immunology 2006;6(8):613-8.
2006: Xavier Valencia; Geoffrey Stephens; Raphaela Goldbach-Mansky; Mildred Wilson; Ethan M Shevach; Peter E Lipsky
TNF downmodulates the function of human CD4+CD25hi T-regulatory cells.
Blood 2006;108(1):253-61.
2006: Dong-Mei Zhao; Angela M Thornton; Richard DiPaolo; Ethan M Shevach
Activated CD4+CD25+ T cells selectively kill B lymphocytes.
Blood 2006;107(10):3925-32.
2006: Itzhak Mendel; Ethan M Shevach
Activated T cells express the OX40 ligand: requirements for induction and costimulatory function.
Immunology 2006;117(2):196-204.
2005: Carine Brinster; Ethan M Shevach
Bone marrow-derived dendritic cells reverse the anergic state of CD4+CD25+ T cells without reversing their suppressive function.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7332-40.
2005: Richard DiPaolo; Deborah D Glass; Karen E Bijwaard; Ethan M Shevach
CD4+CD25+ T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7135-42.
2005: Stacey Allen; Simon Read; Richard DiPaolo; Rebecca S McHugh; Ethan M Shevach; Paul A Gleeson; Ian R van Driel
Promiscuous thymic expression of an autoantigen gene does not result in negative selection of pathogenic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5759-64.
2005: Marika C Kullberg; Valerie Hay; Allen W Cheever; Mizuko Mamura; Alan Sher; John J Letterio; Ethan M Shevach; Ciriaco Piccirillo
TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation.
European journal of immunology 2005;35(10):2886-95.
2005: Irini Sereti; Hiromi Imamichi; Ven Natarajan; Tomozumi Imamichi; Meena S Ramchandani; Yunden Badralmaa; Steve C Berg; Julia A Metcalf; Barbara K Hahn; Jean M Shen; April Powers; Richard Davey; Joseph A Kovacs; Ethan M Shevach; H Clifford Lane
In vivo expansion of CD4CD45RO-CD25 T cells expressing foxP3 in IL-2-treated HIV-infected patients.
The Journal of clinical investigation 2005;115(7):1839-47.
2005: Ronald B Smeltz; June Chen; Ethan M Shevach
Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation.
Immunology 2005;114(4):484-92.
2005: Helen Y Wang; Guangyong Peng; Zhong Guo; Ethan M Shevach; Rongfu Wang
Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2661-70.
2004: Geoffrey L Stephens; Rebecca S McHugh; Matthew J Whitters; Deborah A Young; Deborah Luxenberg; Beatriz M Carreno; Mary Collins; Ethan M Shevach
Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5008-20.
2004: Ethan M Shevach
Regulatory/suppressor T cells in health and disease.
Arthritis and rheumatism 2004;50(9):2721-4.
2004: Ethan M Shevach
Fatal attraction: tumors beckon regulatory T cells.
Nature medicine 2004;10(9):900-1.
2004: Angela M Thornton; Erin E Donovan; Ciriaco Piccirillo; Ethan M Shevach
Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):6519-23.
2004: Ciriaco Piccirillo; Ethan M Shevach
Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance.
Seminars in immunology 2004;16(2):81-8.
2004: Ethan M Shevach
Regulatory T cells. Introduction.
Seminars in immunology 2004;16(2):69-71.
2004: Itzhak Mendel; Kannan Natarajan; Avraham Ben-Nun; Ethan M Shevach
A novel protective model against experimental allergic encephalomyelitis in mice expressing a transgenic TCR-specific for myelin oligodendrocyte glycoprotein.
Journal of neuroimmunology 2004;149(1-2):10-21.
2004: Matthias Hesse; Ciriaco Piccirillo; Yasmine Belkaid; Jeannette Prufer; Margaret M Mentink-Kane; Mary Leusink; Allen W Cheever; Ethan M Shevach; Thomas A Wynn
The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):3157-66.
2004: Sophie Candon; Rebecca S McHugh; Gilles Foucras; Kannan Natarajan; Ethan M Shevach; David Margulies
Spontaneous organ-specific Th2-mediated autoimmunity in TCR transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):2917-24.
2004: Angela M Thornton; Ciriaco Piccirillo; Ethan M Shevach
Activation requirements for the induction of CD4+CD25+ T cell suppressor function.
European journal of immunology 2004;34(2):366-76.
2004: Helen Y Wang; Dean Anthony Lee; Guangyong Peng; Zhong Guo; Yanchun Li; Yukiko Kiniwa; Ethan M Shevach; Rongfu Wang
Tumor-specific human CD4+ regulatory T cells and their ligands: implications for immunotherapy.
Immunity 2004;20(1):107-18.
2003: Ethan M Shevach; Ciriaco Piccirillo; Angela M Thornton; Rebecca S McHugh
Control of T cell activation by CD4+CD25+ suppressor T cells.
Novartis Foundation symposium 2003;252():24-36; discussion 36-44, 106-14.
2002: Yasmine Belkaid; Ciriaco Piccirillo; Susana Mendez; Ethan M Shevach; David L Sacks
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity.
Nature 2002;420(6915):502-7.
2002: Itzhak Mendel; Ethan M Shevach
The IL-10-producing competence of Th2 cells generated in vitro is IL-4 dependent.
European journal of immunology 2002;32(11):3216-24.
2002: Rebecca S McHugh; Ethan M Shevach
The role of suppressor T cells in regulation of immune responses.
The Journal of allergy and clinical immunology 2002;110(5):693-702.
2002: Clemens Scheinecker; Rebecca S McHugh; Ethan M Shevach; Ronald N Germain
Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node.
The Journal of experimental medicine 2002;196(8):1079-90.
2002: Ciriaco Piccirillo; John J Letterio; Angela M Thornton; Rebecca S McHugh; Mizuko Mamura; Hidekazu Mizuhara; Ethan M Shevach
CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness.
The Journal of experimental medicine 2002;196(2):237-46.
2002: Ronald B Smeltz; June Chen; Rolf Ehrhardt; Ethan M Shevach
Role of IFN-gamma in Th1 differentiation: IFN-gamma regulates IL-18R alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expression.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6165-72.
2002: Rebecca S McHugh; Ethan M Shevach
Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):5979-83.
2002: Ethan M Shevach
CD4+ CD25+ suppressor T cells: more questions than answers.
Nature reviews. Immunology 2002;2(6):389-400.
2002: Rebecca S McHugh; Matthew J Whitters; Ciriaco Piccirillo; Deborah A Young; Ethan M Shevach; Mary Collins; Michael C Byrne
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.
Immunity 2002;16(2):311-23.
2002: Itzhak Mendel; Ethan M Shevach
Differentiated Th1 autoreactive effector cells can induce experimental autoimmune encephalomyelitis in the absence of IL-12 and CD40/CD40L interactions.
Journal of neuroimmunology 2002;122(1-2):65-73.
2002: Benjamin M Segal; Deborah D Glass; Ethan M Shevach
Cutting Edge: IL-10-producing CD4+ T cells mediate tumor rejection.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):1-4.
2001: Rebecca S McHugh; Ethan M Shevach; Angela M Thornton
Control of organ-specific autoimmunity by immunoregulatory CD4(+)CD25(+) T cells.
Microbes and infection / Institut Pasteur 2001;3(11):919-27.
2001: Ethan M Shevach; Rebecca S McHugh; Ciriaco Piccirillo; Angela M Thornton
Control of T-cell activation by CD4+ CD25+ suppressor T cells.
Immunological reviews 2001;182():58-67.
2001: Ciriaco Piccirillo; Ethan M Shevach
Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1137-40.
2001: Ronald B Smeltz; June Chen; Jane Hu-Li; Ethan M Shevach
Regulation of interleukin (IL)-18 receptor alpha chain expression on CD4(+) T cells during T helper (Th)1/Th2 differentiation. Critical downregulatory role of IL-4.
The Journal of experimental medicine 2001;194(2):143-53.
2001: Rebecca S McHugh; Ethan M Shevach; David Margulies; Kannan Natarajan
A T cell receptor transgenic model of severe, spontaneous organ-specific autoimmunity.
European journal of immunology 2001;31(7):2094-103.
2001: Ethan M Shevach
Certified professionals: CD4(+)CD25(+) suppressor T cells.
The Journal of experimental medicine 2001;193(11):F41-6.
2001: R Ortmann; Ronald B Smeltz; G Yap; A Sher; Ethan M Shevach
A heritable defect in IL-12 signaling in B10.Q/J mice. I. In vitro analysis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5712-9.
2001: Ethan M Shevach; Rebecca S McHugh; Angela M Thornton; Ciriaco Piccirillo; Kannan Natarajan; David Margulies
Control of autoimmunity by regulatory T cells.
Advances in experimental medicine and biology 2001;490():21-32.
2000: Ethan M Shevach
Suppressor T cells: Rebirth, function and homeostasis.
Current biology : CB 2000;10(15):R572-5.
2000: Benjamin M Segal; JT Chang; Ethan M Shevach
CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):5683-8.
2000: JT Chang; Benjamin M Segal; K Nakanishi; H Okamura; Ethan M Shevach
The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit.
European journal of immunology 2000;30(4):1113-9.
2000: Y J Chiang; H K Kole; K Brown; Mayumi Naramura; S Fukuhara; RJ Hu; Ihn Kyung Jang; J Silvio Gutkind; Ethan M Shevach; Hua Gu
Cbl-b regulates the CD28 dependence of T-cell activation.
Nature 2000;403(6766):216-20.
2000: Ethan M Shevach
Regulatory T cells in autoimmmunity*.
Annual review of immunology 2000;18():423-49.
2000: Angela M Thornton; Ethan M Shevach
Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):183-90.
2000: JT Chang; Benjamin M Segal; Ethan M Shevach
Role of costimulation in the induction of the IL-12/IL-12 receptor pathway and the development of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):100-6.
1999: JT Chang; Ethan M Shevach; Benjamin M Segal
Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells.
The Journal of experimental medicine 1999;189(6):969-78.
1999: E Suri-Payer; A Z Amar; Rebecca S McHugh; Kannan Natarajan; David Margulies; Ethan M Shevach
Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells.
European journal of immunology 1999;29(2):669-77.
1999: Ethan M Shevach; JT Chang; Benjamin M Segal
The critical role of IL-12 and the IL-12R beta 2 subunit in the generation of pathogenic autoreactive Th1 cells.
Springer seminars in immunopathology 1999;21(3):249-62.
1998: L Ding; Ethan M Shevach
Differential effects of CD28 engagement and IL-12 on T cell activation by altered peptide ligands.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6614-21.
1998: Angela M Thornton; Ethan M Shevach
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production.
The Journal of experimental medicine 1998;188(2):287-96.
1998: Benjamin M Segal; Ethan M Shevach
The straight talk on immune deviation.
Clinical immunology and immunopathology 1998;88(1):1-3.
1998: Benjamin M Segal; B K Dwyer; Ethan M Shevach
An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease.
The Journal of experimental medicine 1998;187(4):537-46.
1998: E Suri-Payer; A Z Amar; Angela M Thornton; Ethan M Shevach
CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(3):1212-8.
1998: Ethan M Shevach; A Thornton; E Suri-Payer
T lymphocyte-mediated control of autoimmunity.
Novartis Foundation symposium 1998;215():200-11; discussion 211-30.
1997: Benjamin M Segal; D M Klinman; Ethan M Shevach
Microbial products induce autoimmune disease by an IL-12-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5087-90.
1997: R D Hunziker; F Lynch; Ethan M Shevach; David Margulies
Split tolerance to the MHC class I molecule H-2Dd in animals transgenic for its soluble analog.
Human immunology 1997;52(2):82-94.
1996: E Suri-Payer; P J Kehn; Allen W Cheever; Ethan M Shevach
Pathogenesis of post-thymectomy autoimmune gastritis. Identification of anti-H/K adenosine triphosphatase-reactive T cells.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(4):1799-805.
1996: L Ding; Ethan M Shevach
Activated B cells express CD28/B7-independent costimulatory activity.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(4):1389-96.
1996: Benjamin M Segal; Ethan M Shevach
IL-12 unmasks latent autoimmune disease in resistant mice.
The Journal of experimental medicine 1996;184(2):771-5.
1995: L Ding; J M Green; Craig Thompson; Ethan M Shevach
B7/CD28-dependent and -independent induction of CD40 ligand expression.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(11):5124-32.
1995: C F Mojcik; Daniel R Salomon; A C Chang; Ethan M Shevach
Differential expression of integrins on human thymocyte subpopulations.
Blood 1995;86(11):4206-17.
1995: A Bonomo; P J Kehn; E Payer; Luiz Vicente Rizzo; Allen W Cheever; Ethan M Shevach
Pathogenesis of post-thymectomy autoimmunity. Role of syngeneic MLR-reactive T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(12):6602-11.
1995: K Sturmhöfel; C Brando; F Martinon; Ethan M Shevach; John E Coligan
Antigen-independent, integrin-mediated T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(5):2104-11.
1995: C Brando; Ethan M Shevach
Engagement of the vitronectin receptor (alpha V beta 3) on murine T cells stimulates tyrosine phosphorylation of a 115-kDa protein.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(5):2005-11.
1995: A Bonomo; P J Kehn; Ethan M Shevach
Post-thymectomy autoimmunity: abnormal T-cell homeostasis.
Immunology today 1995;16(2):61-7.
1995: A C Chang; Daniel R Salomon; S Wadsworth; M J Hong; C F Mojcik; S Otto; Ethan M Shevach; John E Coligan
Alpha 3 beta 1 and alpha 6 beta 1 integrins mediate laminin/merosin binding and function as costimulatory molecules for human thymocyte proliferation.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(2):500-10.
1994: Michael K Racke; A Bonomo; D E Scott; Barbara Cannella; A Levine; Cedric S Raine; Ethan M Shevach; M Röcken
Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease.
The Journal of experimental medicine 1994;180(5):1961-6.
1994: M Röcken; J Urban; Ethan M Shevach
Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivo.
The Journal of experimental medicine 1994;179(6):1885-93.
1994: Daniel R Salomon; C F Mojcik; A C Chang; S Wadsworth; D H Adams; John E Coligan; Ethan M Shevach
Constitutive activation of integrin alpha 4 beta 1 defines a unique stage of human thymocyte development.
The Journal of experimental medicine 1994;179(5):1573-84.
1994: Ethan M Shevach; P E Korty
Use of the receptor globulin technology to search for ligands for glycosylphosphatidylinositol-linked cell surface antigens.
Seminars in immunology 1994;6(2):115-21.
1994: L Ding; Ethan M Shevach
Activation of CD4+ T cells by delivery of the B7 costimulatory signal on bystander antigen-presenting cells (trans-costimulation).
European journal of immunology 1994;24(4):859-66.
1994: A Bonomo; P J Kehn; Ethan M Shevach
Premature escape of double-positive thymocytes to the periphery of young mice. Possible role in autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(4):1509-14.
1993: F Lynch; Ethan M Shevach
Gamma delta T cells promote CD4 and CD8 expression by SCID thymocytes.
International immunology 1993;5(8):991-5.
1993: L Ding; P S Linsley; L Y Huang; Ronald N Germain; Ethan M Shevach
IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1224-34.
1993: J B Classen; Ethan M Shevach
Post-thymectomy organ-specific autoimmunity: enhancement by cyclosporine A and inhibition by IL-2.
Autoimmunity 1993;15(1):55-9.
1992: F Lynch; Ethan M Shevach
Activation requirements of newborn thymic gamma delta T cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(7):2307-14.
1992: D Eilat; G E Kikuchi; John E Coligan; Ethan M Shevach
Secretion of a soluble, chimeric gamma delta T-cell receptor-immunoglobulin heterodimer.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(15):6871-5.
1992: L Ding; Ethan M Shevach
IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(10):3133-9.
1992: Ethan M Shevach
Overview of the structure and function of the gamma delta T cell receptor.
Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology 1992;25(2):124-8.
1992: D B Wilde; K Roberts; K Sturmhöfel; G Kikuchi; John E Coligan; Ethan M Shevach
Mouse autoreactive gamma/delta T cells. I. Functional properties of autoreactive T cell hybridomas.
European journal of immunology 1992;22(2):483-9.
1992: Ethan M Shevach
Integrins, gamma delta T cells, and autoimmunity.
Advances in experimental medicine and biology 1992;323():49-55.
1991: K Roberts; Ethan M Shevach
Immunoregulatory role of gamma delta T cells.
Annals of the New York Academy of Sciences 1991;636():1-8.
1991: P E Korty; C Brando; Ethan M Shevach
CD59 functions as a signal-transducing molecule for human T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(12):4092-8.
1991: J B Classen; Ethan M Shevach
Evidence that cyclosporine treatment during pregnancy predisposes offspring to develop autoantibodies.
Transplantation 1991;51(5):1052-7.
1991: K Roberts; W M Yokoyama; P J Kehn; Ethan M Shevach
The vitronectin receptor serves as an accessory molecule for the activation of a subset of gamma/delta T cells.
The Journal of experimental medicine 1991;173(1):231-40.
1990: W M Yokoyama; P J Kehn; D I Cohen; Ethan M Shevach
Chromosomal location of the Ly-49 (A1, YE1/48) multigene family. Genetic association with the NK 1.1 antigen.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(7):2353-8.
1990: Geraldo Pereira; J F Miller; Ethan M Shevach
Mechanism of action of cyclosporine A in vivo. II. T cell priming in vivo to alloantigen can be mediated by an IL-2-independent cyclosporine A-resistant pathway.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(6):2109-16.
1990: D H Presky; M G Low; Ethan M Shevach
Role of phosphatidylinositol-anchored proteins in T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(3):860-8.
1989: W M Yokoyama; L B Jacobs; O Kanagawa; Ethan M Shevach; D I Cohen
A murine T lymphocyte antigen belongs to a supergene family of type II integral membrane proteins.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(4):1379-86.
1989: G D Chazen; Geraldo Pereira; Graham Le Gros; S Gillis; Ethan M Shevach
Interleukin 7 is a T-cell growth factor.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5923-7.
1989: W M Yokoyama; S R Maxfield; Ethan M Shevach
Very early (VEA) and very late (VLA) activation antigens have distinct functions in T lymphocyte activation.
Immunological reviews 1989;109():153-76.
1989: G Trenn; R Taffs; R Hohman; R Kincaid; Ethan M Shevach; Michail V Sitkovsky
Biochemical characterization of the inhibitory effect of CsA on cytolytic T lymphocyte effector functions.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(11):3796-802.
1989: S R Maxfield; K Moulder; F Koning; A Elbe; Georg Stingl; John E Coligan; Ethan M Shevach; W M Yokoyama
Murine T cells express a cell surface receptor for multiple extracellular matrix proteins. Identification and characterization with monoclonal antibodies.
The Journal of experimental medicine 1989;169(6):2173-90.
1989: Ethan M Shevach
Alternative pathways for T lymphocyte activation.
Progress in clinical and biological research 1989;288():127-40.
1989: W M Yokoyama; Ethan M Shevach
T cell activation via cell-surface antigens other than the CD3/T cell receptor complex.
The Year in immunology 1989;4():110-46.
1988: P E Korty; D I Cohen; Ethan M Shevach
A single cDNA encodes multiple Ly-6 antigenic specificities.
European journal of immunology 1988;18(10):1631-4.
1988: G Steiner; F Koning; A Elbe; Erwin Tschachler; W M Yokoyama; Ethan M Shevach; Georg Stingl; John E Coligan
Characterization of T cell receptors on resident murine dendritic epidermal T cells.
European journal of immunology 1988;18(9):1323-8.
1988: W M Yokoyama; F Koning; P J Kehn; Geraldo Pereira; Georg Stingl; John E Coligan; Ethan M Shevach
Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(2):369-76.
1988: J J Sussman; T Saito; Ethan M Shevach; R N Germain; Jonathan D Ashwell
Thy-1- and Ly-6-mediated lymphokine production and growth inhibition of a T cell hybridoma require co-expression of the T cell antigen receptor complex.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(8):2520-6.
1988: K C Gunter; Ronald N Germain; O Leo; C Chan; Ethan M Shevach
Mitogenic activation of EL-4 cells does not require surface Thy-1 expression.
Cellular immunology 1988;112(1):135-46.
1988: C D Black; R A Kroczek; J Barbet; John N Weinstein; Ethan M Shevach
Induction of IL-2 receptor expression in vivo: response to concanavalin A.
Cellular immunology 1988;111(2):420-32.
1987: R A Kroczek; C D Black; J Barbet; Ethan M Shevach
Mechanism of action of cyclosporin A in vivo. I. Cyclosporin A fails to inhibit T lymphocyte activation in response to alloantigens.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(11):3597-603.
1987: R A Kroczek; C D Black; J Barbet; L J Edison; Ethan M Shevach
Induction of IL-2 receptor expression in vivo. Response to allogeneic cells.
Transplantation 1987;44(4):547-53.