Donna Shewach

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O'Konek J J; Boucher P D; Iacco A A; Wilson T E; Shewach D S
MLH1 deficiency enhances tumor cell sensitivity to ganciclovir.
Shewach Donna S; Kuchta Robert D
Introduction to cancer chemotherapeutics.
Flanagan Sheryl A; Krokosky Christina M; Mannava Sudha; Nikiforov Mikhail A; Shewach Donna S
MLH1 deficiency enhances radiosensitization with 5-fluorodeoxyuridine by increasing DNA mismatches.

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2009: O'Konek J J; Boucher P D; Iacco A A; Wilson T E; Shewach D S
MLH1 deficiency enhances tumor cell sensitivity to ganciclovir.
Cancer gene therapy 2009;16(9):683-92.
2009: Shewach Donna S; Kuchta Robert D
Introduction to cancer chemotherapeutics.
Chemical reviews 2009;109(7):2859-61.
2008: Flanagan Sheryl A; Krokosky Christina M; Mannava Sudha; Nikiforov Mikhail A; Shewach Donna S
MLH1 deficiency enhances radiosensitization with 5-fluorodeoxyuridine by increasing DNA mismatches.
Molecular pharmacology 2008;74(3):863-71.
2008: Mannava Sudha; Grachtchouk Vladimir; Wheeler Linda J; Im Michael; Zhuang Dazhong; Slavina Elena G; Mathews Christopher K; Shewach Donna S; Nikiforov Mikhail A
Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.
Cell cycle (Georgetown, Tex.) 2008;7(15):2392-400.
2007: Shewach Donna S; Lawrence Theodore S
Antimetabolite radiosensitizers.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(26):4043-50.
2007: Flanagan Sheryl A; Robinson Blaine W; Krokosky Christina M; Shewach Donna S
Mismatched nucleotides as the lesions responsible for radiosensitization with gemcitabine: a new paradigm for antimetabolite radiosensitizers.
Molecular cancer therapeutics 2007;6(6):1858-68.
2006: Gentry Brian G; Boucher Paul D; Shewach Donna S
Hydroxyurea induces bystander cytotoxicity in cocultures of herpes simplex virus thymidine kinase-expressing and nonexpressing HeLa cells incubated with ganciclovir.
Cancer research 2006;66(7):3845-51.
2006: Boucher Paul D; Im Michael M; Freytag Svend O; Shewach Donna S
A novel mechanism of synergistic cytotoxicity with 5-fluorocytosine and ganciclovir in double suicide gene therapy.
Cancer research 2006;66(6):3230-7.
2005: Boucher Paul D; Shewach Donna S
In vitro and in vivo enhancement of ganciclovir-mediated bystander cytotoxicity with gemcitabine.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(6):1064-71.
2005: Gentry B G; Im M; Boucher P D; Ruch R J; Shewach D S
GCV phosphates are transferred between HeLa cells despite lack of bystander cytotoxicity.
Gene therapy 2005;12(13):1033-41.
2004: Suh W Warren; Schott Anne F; Hayman James A; Schipper Matthew J; Shewach Donna S; Pierce Lori J
A phase I dose escalation trial of gemcitabine with radiotherapy for breast cancer in the treatment of unresectable chest wall recurrences.
The breast journal 2004;10(3):204-10.
2004: Leu Kirsten M; Ostruszka Leo J; Shewach Donna; Zalupski Mark; Sondak Vernon; Biermann J Sybil; Lee Julia Shin-Jung; Couwlier Carol; Palazzolo Krisinda; Baker Laurence H
Laboratory and clinical evidence of synergistic cytotoxicity of sequential treatment with gemcitabine followed by docetaxel in the treatment of sarcoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(9):1706-12.
2004: Robinson Blaine W; Ostruszka Leo; Im Michael M; Shewach Donna S
Promising combination therapies with gemcitabine.
Seminars in oncology 2004;31(2 Suppl 5):2-12.
2003: Robinson Blaine W; Im Michael M; Ljungman Mats; Praz Françoise; Shewach Donna S
Enhanced radiosensitization with gemcitabine in mismatch repair-deficient HCT116 cells.
Cancer research 2003;63(20):6935-41.
2003: Ostruszka Leo J; Shewach Donna S
The role of DNA synthesis inhibition in the cytotoxicity of 2',2'-difluoro-2'-deoxycytidine.
Cancer chemotherapy and pharmacology 2003;52(4):325-32.
2003: Shewach Donna S; Lawrence Theodore S
It's what's inside that counts.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(18):3383-4.
2002: Kanelakis Kimon C; Shewach Donna S; Pratt William B
Nucleotide binding states of hsp70 and hsp90 during sequential steps in the process of glucocorticoid receptor.hsp90 heterocomplex assembly.
The Journal of biological chemistry 2002;277(37):33698-703.
2002: Fernstrom Martha J; Koffler Lucas D; Abou-Rjaily George; Boucher Paul D; Shewach Donna S; Ruch Randall J
Neoplastic reversal of human ovarian carcinoma cells transfected with connexin43.
Experimental and molecular pathology 2002;73(1):54-60.
2002: Boucher P D; Ostruszka L J; Murphy P J M; Shewach D S
Hydroxyurea significantly enhances tumor growth delay in vivo with herpes simplex virus thymidine kinase/ganciclovir gene therapy.
Gene therapy 2002;9(15):1023-30.
2002: Shewach Donna S; Murphy Patrick J; Robinson Blaine W; Vuletich Jennifer; Boucher Paul D; Blobaum Anna L; Zerbe Laura; Secrist John A; Parker William B
Multi-log cytotoxicity of carbocyclic 2'-deoxyguanosine in HSV-TK-expressing human tumor cells.
Human gene therapy 2002;13(4):543-51.
2001: Robinson B W; Shewach D S
Radiosensitization by gemcitabine in p53 wild-type and mutant MCF-7 breast carcinoma cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(8):2581-9.
2001: Eisbruch A; Shewach D S; Bradford C R; Littles J F; Teknos T N; Chepeha D B; Marentette L J; Terrell J E; Hogikyan N D; Dawson L A; Urba S; Wolf G T; Lawrence T S
Radiation concurrent with gemcitabine for locally advanced head and neck cancer: a phase I trial and intracellular drug incorporation study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(3):792-9.
2001: Morishima Y; Kanelakis K C; Murphy P J; Shewach D S; Pratt W B
Evidence for iterative ratcheting of receptor-bound hsp70 between its ATP and ADP conformations during assembly of glucocorticoid receptor.hsp90 heterocomplexes.
Biochemistry 2001;40(4):1109-16.
2000: Parker W B; Shaddix S C; Rose L M; Waud W R; Shewach D S; Tiwari K N; Secrist J A
Metabolism of 4'-thio-beta-D-arabinofuranosylcytosine in CEM cells.
Biochemical pharmacology 2000;60(12):1925-32.
2000: Ostruszka L J; Shewach D S
The role of cell cycle progression in radiosensitization by 2',2'-difluoro-2'-deoxycytidine.
Cancer research 2000;60(21):6080-8.
2000: Boucher P D; Ostruszka L J; Shewach D S
Synergistic enhancement of herpes simplex virus thymidine kinase/ganciclovir-mediated cytoxicity by hydroxyurea.
Cancer research 2000;60(6):1631-6.
1999: Lawrence T S; Eisbruch A; McGinn C J; Fields M T; Shewach D S
Radiosensitization by gemcitabine.
Oncology (Williston Park, N.Y.) 1999;13(10 Suppl 5):55-60.
1999: Parker W B; Shaddix S C; Rose L M; Shewach D S; Hertel L W; Secrist J A; Montgomery J A; Bennett L L
Comparison of the mechanism of cytotoxicity of 2-chloro-9-(2-deoxy-2- fluoro-beta-D-arabinofuranosyl)adenine, 2-chloro-9-(2-deoxy-2-fluoro- beta-D-ribofuranosyl)adenine, and 2-chloro-9-(2-deoxy-2,2-difluoro- beta-D-ribofuranosyl)adenine in CEM cells.
Molecular pharmacology 1999;55(3):515-20.
1999: Rubsam L Z; Boucher P D; Murphy P J; KuKuruga M; Shewach D S
Cytotoxicity and accumulation of ganciclovir triphosphate in bystander cells cocultured with herpes simplex virus type 1 thymidine kinase-expressing human glioblastoma cells.
Cancer research 1999;59(3):669-75.
1998: Rubsam L Z; Davidson B L; Shewach D S
Superior cytotoxicity with ganciclovir compared with acyclovir and 1-beta-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing cells: a novel paradigm for cell killing.
Cancer research 1998;58(17):3873-82.
1998: Bennett L L; Allan P W; Arnett G; Shealy Y F; Shewach D S; Mason W S; Fourel I; Parker W B
Metabolism in human cells of the D and L enantiomers of the carbocyclic analog of 2'-deoxyguanosine: substrate activity with deoxycytidine kinase, mitochondrial deoxyguanosine kinase, and 5'-nucleotidase.
Antimicrobial agents and chemotherapy 1998;42(5):1045-51.
1998: Boucher P D; Ruch R J; Shewach D S
Differential ganciclovir-mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing herpes simplex virus thymidine kinase.
Human gene therapy 1998;9(6):801-14.
1997: Rubsam L Z; Shewach D S
Improved method to prepare RNA-free DNA from mammalian cells.
Journal of chromatography. B, Biomedical sciences and applications 1997;702(1-2):61-8.
1997: Hughes T L; Hahn T M; Reynolds K K; Shewach D S
Kinetic analysis of human deoxycytidine kinase with the true phosphate donor uridine triphosphate.
Biochemistry 1997;36(24):7540-7.
1997: Lawrence T S; Chang E Y; Hahn T M; Shewach D S
Delayed radiosensitization of human colon carcinoma cells after a brief exposure to 2',2'-difluoro-2'-deoxycytidine (Gemcitabine).
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(5):777-82.
1997: Lawrence T S; Eisbruch A; Shewach D S
Gemcitabine-mediated radiosensitization.
Seminars in oncology 1997;24(2 Suppl 7):S7-24-S7-28.
1996: Shewach D S; Lawrence T S
Radiosensitization of human solid tumor cell lines with gemcitabine.
Seminars in oncology 1996;23(5 Suppl 10):65-71.
1996: McGinn C J; Shewach D S; Lawrence T S
Radiosensitizing nucleosides.
Journal of the National Cancer Institute 1996;88(17):1193-203.
1996: Plumb T J; Bosch A; Roessler B J; Shewach D S; Davidson B L
Hypoxanthine-guanine phosphoribosyltransferase (HPRT) expression in the central nervous system of HPRT-deficient mice following adenoviral-mediated gene transfer.
Neuroscience letters 1996;214(2-3):159-62.
1996: Robertson J M; Shewach D S; Lawrence T S
Preclinical studies of chemotherapy and radiation therapy for pancreatic carcinoma.
Cancer 1996;78(3 Suppl):674-9.
1996: Palmer R K; Yule D I; Shewach D S; Williams J A; Fisher S K
Paracrine mediation of calcium signaling in human SK-N-MCIXC neuroepithelioma cells.
The American journal of physiology 1996;271(1 Pt 1):C43-53.
1996: Lawrence T S; Chang E Y; Hahn T M; Hertel L W; Shewach D S
Radiosensitization of pancreatic cancer cells by 2',2'-difluoro-2'-deoxycytidine.
International journal of radiation oncology, biology, physics 1996;34(4):867-72.
1996: Shewach D S; Lawrence T S
Gemcitabine and radiosensitization in human tumor cells.
Investigational new drugs 1996;14(3):257-63.
1995: Shewach D S; Lawrence T S
Radiosensitization of human tumor cells by gemcitabine in vitro.
Seminars in oncology 1995;22(4 Suppl 11):68-71.
1994: Shewach D S; Hahn T M; Chang E; Hertel L W; Lawrence T S
Metabolism of 2',2'-difluoro-2'-deoxycytidine and radiation sensitization of human colon carcinoma cells.
Cancer research 1994;54(12):3218-23.
1994: Shewach D S; Zerbe L K; Hughes T L; Roessler B J; Breakefield X O; Davidson B L
Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells.
Cancer gene therapy 1994;1(2):107-12.
1994: Davidson B L; Doran S E; Shewach D S; Latta J M; Hartman J W; Roessler B J
Expression of Escherichia coli beta-galactosidase and rat HPRT in the CNS of Macaca mulatta following adenoviral mediated gene transfer.
Experimental neurology 1994;125(2):258-67.
1994: Doran S E; Roessler B J; Hartman J W; Hoff J T; Shewach D S; Davidson B L
Adenovirus-mediated in vivo gene transfer into the central nervous system of a nonhuman primate (resident award paper).
Clinical neurosurgery 1994;41():242-57.
1993: Canman C E; Lawrence T S; Shewach D S; Tang H Y; Maybaum J
Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate.
Cancer research 1993;53(21):5219-24.
1993: Chern J W; Lee H Y; Chen C S; Shewach D S; Daddona P E; Townsend L B
Nucleosides. 5. Synthesis of guanine and formycin B derivatives as potential inhibitors of purine nucleoside phosphorylase.
Journal of medicinal chemistry 1993;36(8):1024-31.
1993: Shewach D S; Liotta D C; Schinazi R F
Affinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2'-deoxycytidine kinase.
Biochemical pharmacology 1993;45(7):1540-3.
1992: Shewach D S; Krawczyk S H; Acevedo O L; Townsend L B
Inhibition of adenosine deaminase by azapurine ribonucleosides.
Biochemical pharmacology 1992;44(9):1697-700.
1992: Shewach D S
Quantitation of deoxyribonucleoside 5'-triphosphates by a sequential boronate and anion-exchange high-pressure liquid chromatographic procedure.
Analytical biochemistry 1992;206(1):178-82.
1992: Shewach D S; Reynolds K K; Hertel L
Nucleotide specificity of human deoxycytidine kinase.
Molecular pharmacology 1992;42(3):518-24.
1992: Owens J K; Shewach D S; Ullman B; Mitchell B S
Resistance to 1-beta-D-arabinofuranosylcytosine in human T-lymphoblasts mediated by mutations within the deoxycytidine kinase gene.
Cancer research 1992;52(9):2389-93.
1992: Shewach D S; Ellero J; Mancini W R; Ensminger W D
Decrease in TTP pools mediated by 5-bromo-2'-deoxyuridine exposure in a human glioblastoma cell line.
Biochemical pharmacology 1992;43(7):1579-85.
1992: Nakamura J; Del Monte M A; Shewach D; Lattimer S A; Greene D A
Inhibition of phosphatidylinositol synthase by glucose in human retinal pigment epithelial cells.
The American journal of physiology 1992;262(4 Pt 1):E417-26.
1992: Kemena A; Gandhi V; Shewach D S; Keating M; Plunkett W
Inhibition of fludarabine metabolism by arabinosylcytosine during therapy.
Cancer chemotherapy and pharmacology 1992;31(3):193-9.
1991: Heimburger D K; Shewach D S; Lawrence T S
The effect of fluorodeoxyuridine on sublethal damage repair in human colon cancer cells.
International journal of radiation oncology, biology, physics 1991;21(4):983-7.
1991: Chottiner E G; Shewach D S; Datta N S; Ashcraft E; Gribbin D; Ginsburg D; Fox I H; Mitchell B S
Cloning and expression of human deoxycytidine kinase cDNA.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1531-5.
1991: Lawrence T S; Heimburger D K; Shewach D S
The effects of leucovorin and dipyridamole on fluoropyrimidine-induced radiosensitization.
International journal of radiation oncology, biology, physics 1991;20(2):377-81.
1990: Bruso C E; Shewach D S; Lawrence T S
Fluorodeoxyuridine-induced radiosensitization and inhibition of DNA double strand break repair in human colon cancer cells.
International journal of radiation oncology, biology, physics 1990;19(6):1411-7.
1989: Shewach D S; Mitchell B S
Differential metabolism of 9-beta-D-arabinofuranosylguanine in human leukemic cells.
Cancer research 1989;49(23):6498-502.
1989: Datta N S; Shewach D S; Mitchell B S; Fox I H
Kinetic properties and inhibition of human T lymphoblast deoxycytidine kinase.
The Journal of biological chemistry 1989;264(16):9359-64.
1989: Datta N S; Shewach D S; Hurley M C; Mitchell B S; Fox I H
Human T-lymphoblast deoxycytidine kinase: purification and properties.
Biochemistry 1989;28(1):114-23.
1989: Datta N S; Shewach D S; Hurley M C; Mitchell B S; Fox I H
Properties of highly purified human T lymphoblast (MOLT-4) deoxycytidine kinase.
Advances in experimental medicine and biology 1989;253B():87-92.
1986: Wilson J M; O'Toole T E; Argos P; Shewach D S; Daddona P E; Kelley W N
Human adenine phosphoribosyltransferase. Complete amino acid sequence of the erythrocyte enzyme.
The Journal of biological chemistry 1986;261(29):13677-83.
1986: Shewach D S; Plunkett W
Cellular retention of 9-beta-D-arabinofuranosyladenine 5'-triphosphate and the pattern of recovery of DNA synthesis in Chinese hamster ovary cells.
Cancer research 1986;46(4 Pt 1):1581-4.
1986: Shewach D S; Chern J W; Pillote K E; Townsend L B; Daddona P E
Potentiation of 2'-deoxyguanosine cytotoxicity by a novel inhibitor of purine nucleoside phosphorylase, 8-amino-9-benzylguanine.
Cancer research 1986;46(2):519-23.
1985: Shewach D S; Daddona P E; Ashcraft E; Mitchell B S
Metabolism and selective cytotoxicity of 9-beta-D-arabinofuranosylguanine in human lymphoblasts.
Cancer research 1985;45(3):1008-14.
1985: Daddona P E; Orkin S H; Shewach D S; Kelley W N
cDNA and amino acid sequence of human adenosine deaminase.
Annals of the New York Academy of Sciences 1985;451():238-44.
1984: Daddona P E; Shewach D S; Kelley W N; Argos P; Markham A F; Orkin S H
Human adenosine deaminase. cDNA and complete primary amino acid sequence.
The Journal of biological chemistry 1984;259(19):12101-6.
1983: Orkin S H; Daddona P E; Shewach D S; Markham A F; Bruns G A; Goff S C; Kelley W N
Molecular cloning of human adenosine deaminase gene sequences.
The Journal of biological chemistry 1983;258(21):12753-6.
1982: Shewach D S; Plunkett W
Correlation of cytotoxicity with total intracellular exposure to 9-beta-D-arabinofuranosyladenine 5'-triphosphate.
Cancer research 1982;42(9):3637-41.
1982: Shewach D S; Plunkett W
Effect of 2'-deoxycoformycin on the inhibition of deoxyribonucleic acid synthesis by 9-beta-D-arabinofuranosyladenine 5'-triphosphate.
Biochemical pharmacology 1982;31(11):2103-9.
1979: Shewach D S; Plunkett W
Effect of 2'-deoxycoformycin on the biologic half-life of 9-beta-D-arabinofuranosyladenine 5'-triphosphate in CHO cells.
Biochemical pharmacology 1979;28(15):2401-4.

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