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Xu Shi-wen

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Mats Dreifaldt; Andrzej Loesch; John R Muddle; Xu Shi-wen; Domingos Souza; Lennart Bodin; Audrey Dooley; Michael R Dashwood
The vasa vasorum and associated endothelial nitric oxide synthase is more important for saphenous vein than arterial bypass grafts.
Xu Shi-wen; Katherine Thompson; Murray Baron; Christopher P Denton; Korsa Khan; Andrew Leask; Shangxi Liu; Hannah Murphy-Marshman; David J Abraham
Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts.
Nora M Thoua; Emma C Derrett-Smith; Audrey Dooley; Korsa Khan; Xu Shi-wen; Christopher P Denton
Gut fibrosis with altered colonic contractility in a mouse model of scleroderma.

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2013: Mats Dreifaldt; Andrzej Loesch; John R Muddle; Xu Shi-wen; Domingos Souza; Lennart Bodin; Audrey Dooley; Michael R Dashwood
The vasa vasorum and associated endothelial nitric oxide synthase is more important for saphenous vein than arterial bypass grafts.
Angiology 2013;64(4):293-9.
2012: Xu Shi-wen; Katherine Thompson; Murray Baron; Christopher P Denton; Korsa Khan; Andrew Leask; Shangxi Liu; Hannah Murphy-Marshman; David J Abraham
Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts.
Rheumatology (Oxford, England) 2012;51(12):2146-54.
2012: Nora M Thoua; Emma C Derrett-Smith; Audrey Dooley; Korsa Khan; Xu Shi-wen; Christopher P Denton
Gut fibrosis with altered colonic contractility in a mouse model of scleroderma.
Rheumatology (Oxford, England) 2012;51(11):1989-98.
2012: David Lagares; Santiago Lamas; Andrew Leask; Shangxi Liu; David Abraham; Oscar Busnadiego; Patricia Carreira; David E Carter; Benjamin A Fontaine; Rosa Ana García-Fernández; Mohit Kapoor; Barry S Shea; Xu Shi-wen; Andrew M Tager; Fernando Rodríguez-Pascual
Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation.
Arthritis and rheumatism 2012;64(5):1653-64.
2012: Jonathan P Knowles; David J Abraham; Ashish Bhalla; Michael R Dashwood; Samer-ul Haque; Xu Shi-wen; Irving Taylor; Marc C Winslet; Shi-Yu Yang; Marilena Loizidou
Endothelin-1 stimulates colon cancer adjacent fibroblasts.
International journal of cancer. Journal international du cancer 2012;130(6):1264-72.
2012: Gareth Williams; David Abraham; Daryll M Baker; Sadasivam Selvakumar; Xu Shi-wen; Janice C S Tsui
Nitric oxide manipulation: a therapeutic target for peripheral arterial disease?
Cardiology research and practice 2012;2012():656247.
2012: Hemanshu Patel; Sidney G Shaw; Xu Shi-wen; David Abraham; Daryll M Baker; Janice C S Tsui
Toll-like receptors in ischaemia and its potential role in the pathophysiology of muscle damage in critical limb ischaemia.
Cardiology research and practice 2012;2012():121237.
2011: Sunil K Parapuram; Xu Shi-wen; Ian D Welch; David J Abraham; Murray Baron; Christopher P Denton; Christopher Elliott; Helen Jones; Andrew Leask
Loss of PTEN expression by dermal fibroblasts causes skin fibrosis.
The Journal of investigative dermatology 2011;131(10):1996-2003.
2011: Michael R Dashwood; Ann Crump; Xu Shi-wen; Andrzej Loesch
Identification of neuronal nitric oxide synthase (nNOS) in human penis: a potential role of reduced neuronally-derived nitric oxide in erectile dysfunction.
Current pharmaceutical biotechnology 2011;12(9):1316-21.
2011: Alan M Holmes; Markella Ponticos; Xu Shi-wen; Christopher P Denton; David J Abraham
Elevated CCN2 expression in scleroderma: a putative role for the TGFβ accessory receptors TGFβRIII and endoglin.
Journal of cell communication and signaling 2011;5(3):173-7.
2011: Janice C Tsui; Xu Shi-wen
Endothelin-1 in peripheral arterial disease: a potential role in muscle damage.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;63(6):473-6.
2011: Michael R Dashwood; Audrey Dooley; Xu Shi-wen; David J Abraham; Mats Dreifaldt; Domingos S R Souza
Perivascular fat-derived leptin: a potential role in improved vein graft performance in coronary artery bypass surgery.
Interactive cardiovascular and thoracic surgery 2011;12(2):170-3.
2011: Yunliang Chen; Andrew Leask; David J Abraham; Laura Kennedy; Xu Shi-wen; Christopher P Denton; Carol M Black; Liaquat S Verjee; Mark Eastwood
Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism.
Fibrogenesis & tissue repair 2011;4(1):9.
2011: Matthew McCann; Roxana Monemdjou; Sunil K Parapuram; Gemma Perez; Xu Shi-wen; David J Abraham; Leslie J Crofford; Christopher P Denton; Hassan Fahmi; Parisa Ghassemi-Kakroodi; Fumiaki Kojima; Andrew Leask; Shangxi Liu; Johanne Martel-Pelletier; Mohit Kapoor
mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis.
Arthritis research & therapy 2011;13(1):R6.
2011: Shangxi Liu; Xu Shi-wen; David J Abraham; Andrew Leask
CCN2 is required for bleomycin-induced skin fibrosis in mice.
Arthritis and rheumatism 2011;63(1):239-46.
2010: Audrey Dooley; Xu Shi-wen; Nima Aden; Thomas Tranah; Nirupa Desai; Christopher P Denton; David J Abraham; Richard Bruckdorfer
Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate.
Rheumatology (Oxford, England) 2010;49(11):2024-36.
2010: Sonali Sonnylal; Xu Shi-wen; Patricia Leoni; Katherine Naff; Carolyn S Van Pelt; Hiroyuki Nakamura; Andrew Leask; David Abraham; George Bou-Gharios; Benoit de Crombrugghe
Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.
Arthritis and rheumatism 2010;62(5):1523-32.
2010: Xu Shi-wen; Mark Eastwood; Richard J Stratton; Christopher P Denton; Andrew Leask; David J Abraham
Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts.
Rheumatology (Oxford, England) 2010;49(2):259-63.
2010: Emma C Derrett-Smith; Audrey Dooley; Korsa Khan; Xu Shi-wen; David Abraham; Christopher P Denton
Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma.
Arthritis research & therapy 2010;12(2):R69.
2009: Markella Ponticos; holmes alan; Xu Shi-wen; Patricia Leoni; Korsa Khan; Vineeth S Rajkumar; Rachel K Hoyles; George Bou-Gharios; Carol M Black; Christopher P Denton; David J Abraham; Andrew Leask; Gisela E Lindahl
Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.
Arthritis and rheumatism 2009;60(7):2142-55.
2009: Andrew Leask; Sunil K Parapuram; Xu Shi-wen; David J Abraham
Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?
Journal of cell communication and signaling 2009;3(2):89-94.
2009: Xu Shi-wen; Sunil K Parapuram; Daphne Pala; Yunliang Chen; David E Carter; Mark Eastwood; Christopher P Denton; David J Abraham; Andrew Leask
Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts.
Arthritis and rheumatism 2009;60(1):234-41.
2008: Andrew Leask; Xu Shi-wen; Korsa Khan; Yunliang Chen; holmes alan; Mark Eastwood; Christopher P Denton; Carol M Black; David J Abraham
Loss of protein kinase Cepsilon results in impaired cutaneous wound closure and myofibroblast function.
Journal of cell science 2008;121(Pt 20):3459-67.
2008: Mohit Kapoor; Shangxi Liu; Xu Shi-wen; Kun Huh; Matthew McCann; Christopher P Denton; James R Woodgett; David J Abraham; Andrew Leask
GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism.
The Journal of clinical investigation 2008;118(10):3279-90.
2008: Shangxi Liu; Mohit Kapoor; Xu Shi-wen; Laura Kennedy; Christopher P Denton; Glogauer Michael; David J Abraham; Andrew Leask
Role of Rac1 in a bleomycin-induced scleroderma model using fibroblast-specific Rac1-knockout mice.
Arthritis and rheumatism 2008;58(7):2189-95.
2008: Laura Kennedy; Xu Shi-wen; David E Carter; David J Abraham; Andrew Leask
Fibroblast adhesion results in the induction of a matrix remodeling gene expression program.
Matrix biology : journal of the International Society for Matrix Biology 2008;27(4):274-81.
2008: Xu Shi-wen; Andrew Leask; David Abraham
Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis.
Cytokine & growth factor reviews 2008;19(2):133-44.
2008: Janice C S Tsui; Daryll M Baker; Sidney G Shaw; Xu Shi-wen; Michael R Dashwood
Nitric oxide synthase in critically ischaemic muscle and alterations in isoform expression during revascularization surgery.
The British journal of surgery 2008;95(1):72-9.
2007: Xu Shi-wen; Laura Kennedy; Elisabetta A Renzoni; George Bou-Gharios; Roland M Du Bois; Carol M Black; Christopher P Denton; David J Abraham; Andrew Leask
Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.
Arthritis and rheumatism 2007;56(12):4189-94.
2007: Xu Shi-wen; Elisabetta A Renzoni; Laura Kennedy; Sarah Howat; Yunliang Chen; Jeremy Pearson; George Bou-Gharios; Michael R Dashwood; Roland M Du Bois; Carol M Black; Christopher P Denton; David J Abraham; Andrew Leask
Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.
Matrix biology : journal of the International Society for Matrix Biology 2007;26(8):625-32.
2007: Carmen Fonseca; Gisela E Lindahl; Markella Ponticos; Piersante Sestini; Elisabetta A Renzoni; holmes alan; Paolo Spagnolo; P Pantelidis; Patricia Leoni; Neil McHugh; Carmel J Stock; Xu Shi-wen; Christopher P Denton; Carol M Black; Kenneth I Welsh; Roland M Du Bois; David J Abraham
A polymorphism in the CTGF promoter region associated with systemic sclerosis.
The New England journal of medicine 2007;357(12):1210-20.
2007: Audrey Dooley; Beirong Gao; Xu Shi-wen; David J Abraham; Carol M Black; Michael Jacobs; K Richard Bruckdorfer
Effect of nitric oxide and peroxynitrite on type I collagen synthesis in normal and scleroderma dermal fibroblasts.
Free radical biology & medicine 2007;43(2):253-64.
2007: Laura Kennedy; Shangxi Liu; Xu Shi-wen; Yunliang Chen; Mark Eastwood; Mojhgan Sabetkar; David E Carter; Karen M Lyons; Carol M Black; David J Abraham; Andrew Leask
CCN2 is necessary for the function of mouse embryonic fibroblasts.
Experimental cell research 2007;313(5):952-64.
2007: Michael R Dashwood; Audrey Dooley; Xu Shi-wen; David J Abraham; Domingos S R Souza
Does periadventitial fat-derived nitric oxide play a role in improved saphenous vein graft patency in patients undergoing coronary artery bypass surgery?
Journal of vascular research 2007;44(3):175-81.
2006: Xu Shi-wen; Fernando Rodríguez-Pascual; Santiago Lamas; holmes alan; Sarah Howat; Jeremy Pearson; Michael R Dashwood; Roland M Du Bois; Christopher P Denton; Carol M Black; David J Abraham; Andrew Leask
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors.
Molecular and cellular biology 2006;26(14):5518-27.
2006: Rajesh P Menon; Malini R Menon; Xu Shi-wen; Elisabetta A Renzoni; George Bou-Gharios; Carol M Black; David J Abraham
Hammerhead ribozyme-mediated silencing of the mutant fibrillin-1 of tight skin mouse: insight into the functional role of mutant fibrillin-1.
Experimental cell research 2006;312(9):1463-74.
2006: Xu Shi-wen; Lee-Anne Stanton; Laura Kennedy; Daphne Pala; Yunliang Chen; Sarah Howat; Elisabetta A Renzoni; David E Carter; George Bou-Gharios; Richard J Stratton; Jeremy Pearson; Frank Beier; Karen M Lyons; Carol M Black; David J Abraham; Andrew Leask
CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.
The Journal of biological chemistry 2006;281(16):10715-26.
2006: Yunliang Chen; Xu Shi-wen; Mark Eastwood; Carol M Black; Christopher P Denton; Andrew Leask; David J Abraham
Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts.
Arthritis and rheumatism 2006;54(4):1309-16.
2006: Charlotte E Waters; Xu Shi-wen; Christopher P Denton; David J Abraham; Jeremy Pearson
Signaling pathways regulating intercellular adhesion molecule 1 expression by endothelin 1: comparison with interleukin-1beta in normal and scleroderma dermal fibroblasts.
Arthritis and rheumatism 2006;54(2):649-60.
2005: Yunliang Chen; Xu Shi-wen; Jonathan van Beek; Laura Kennedy; Marilyn McLeod; Elisabetta A Renzoni; George Bou-Gharios; Sarah Wilcox-Adelman; Paul F Goetinck; Mark Eastwood; Carol M Black; David J Abraham; Andrew Leask
Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.
The American journal of pathology 2005;167(6):1699-711.
2005: Michael R Dashwood; Kay Savage; Audrey Dooley; Xu Shi-wen; David J Abraham; Domingos S R Souza
Effect of vein graft harvesting on endothelial nitric oxide synthase and nitric oxide production.
The Annals of thoracic surgery 2005;80(3):939-44.
2004: Yunliang Chen; David J Abraham; Xu Shi-wen; Jeremy Pearson; Carol M Black; Karen M Lyons; Andrew Leask
CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin.
Molecular biology of the cell 2004;15(12):5635-46.
2004: Xu Shi-wen; Yunliang Chen; Christopher P Denton; Mark Eastwood; Elisabetta A Renzoni; George Bou-Gharios; Jeremy Pearson; Michael R Dashwood; Roland M Du Bois; Carol M Black; Andrew Leask; David J Abraham
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.
Molecular biology of the cell 2004;15(6):2707-19.
2004: Elisabetta A Renzoni; David J Abraham; Sarah Howat; Xu Shi-wen; Piersante Sestini; George Bou-Gharios; Athol U Wells; Srihari Veeraraghavan; Andrew G Nicholson; Christopher P Denton; Andrew Leask; Jeremy Pearson; Carol M Black; Kenneth I Welsh; Roland M Du Bois
Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.
Respiratory research 2004;5():24.
2003: holmes alan; David J Abraham; Youjun Chen; Christopher P Denton; Xu Shi-wen; Carol M Black; Andrew Leask
Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1.
The Journal of biological chemistry 2003;278(43):41728-33.
2003: Christopher P Denton; Bing Zheng; Lowri A Evans; Xu Shi-wen; Voon H Ong; Ivan B Fisher; Konstantinos Lazaridis; David J Abraham; Carol M Black; Benoit de Crombrugghe
Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice.
The Journal of biological chemistry 2003;278(27):25109-19.
2002: Andrew Leask; David J Abraham; D R Finlay; holmes alan; D Pennington; Xu Shi-wen; Y Chen; K Venstrom; X Dou; Markella Ponticos; C Black; C Bernabeu; J K Jackman; P R Findell; M Kari Connolly
Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts.
Arthritis and rheumatism 2002;46(7):1857-65.
2001: Xu Shi-wen; Christopher P Denton; Michael R Dashwood; holmes alan; George Bou-Gharios; Jeremy Pearson; Carol M Black; David J Abraham
Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.
The Journal of investigative dermatology 2001;116(3):417-25.
2000: Xu Shi-wen; D Pennington; holmes alan; Andrew Leask; D Bradham; J R Beauchamp; Carmen Fonseca; Roland M Du Bois; G R Martin; Carol M Black; David J Abraham
Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis.
Experimental cell research 2000;259(1):213-24.
1999: Carol M Black; A J Silman; Ariane Herrick; Christopher P Denton; H Wilson; J Newman; L Pompon; Xu Shi-wen
Interferon-alpha does not improve outcome at one year in patients with diffuse cutaneous scleroderma: results of a randomized, double-blind, placebo-controlled trial.
Arthritis and rheumatism 1999;42(2):299-305.
1998: C P Denton; Xu Shi-wen; A Sutton; D J Abraham; Carol M Black; Jeremy Pearson
Scleroderma fibroblasts promote migration of mononuclear leucocytes across endothelial cell monolayers.
Clinical and experimental immunology 1998;114(2):293-300.
1998: Christopher Bunn; C P Denton; Xu Shi-wen; C Knight; Carol M Black
Anti-RNA polymerases and other autoantibody specificities in systemic sclerosis.
British journal of rheumatology 1998;37(1):15-20.
1997: Xu Shi-wen; Christopher P Denton; A McWhirter; George Bou-Gharios; David J Abraham; Roland M Du Bois; Carol M Black
Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis.
Arthritis and rheumatism 1997;40(7):1237-44.
1994: Xu Shi-wen; M Panesar; R Vancheeswaran; J Mason; D Haskard; C Black; I Olsen; D Abraham
Expression and shedding of intercellular adhesion molecule 1 and lymphocyte function-associated antigen 3 by normal and scleroderma fibroblasts. Effects of interferon-gamma, tumor necrosis factor alpha, and estrogen.
Arthritis and rheumatism 1994;37(11):1689-97.