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Wuxian Shi

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TOP 3
Annette N Ratcliff; Wuxian Shi; Eric J Arts
HIV-1 resistance to maraviroc conferred by a CD4 binding site mutation in the envelope glycoprotein gp120.
Philip D Kiser; Mark R Chance; Erik R Farquhar; Wuxian Shi; Xuewu Sui; Krzysztof Palczewski
Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.
Wuxian Shi; Marco Punta; Jen Bohon; J Michael Sauder; Rhijuta D'Mello; Mike Sullivan; John Toomey; Don Abel; Marco Lippi; Andrea Passerini; Paolo Frasconi; Stephen K Burley; Burkhard Rost; Mark R Chance
Characterization of metalloproteins by high-throughput X-ray absorption spectroscopy.

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All Publications

2013: Annette N Ratcliff; Wuxian Shi; Eric J Arts
HIV-1 resistance to maraviroc conferred by a CD4 binding site mutation in the envelope glycoprotein gp120.
Journal of virology 2013;87(2):923-34.
2012: Philip D Kiser; Mark R Chance; Erik R Farquhar; Wuxian Shi; Xuewu Sui; Krzysztof Palczewski
Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(41):E2747-56.
2011: Wuxian Shi; Marco Punta; Jen Bohon; J Michael Sauder; Rhijuta D'Mello; Mike Sullivan; John Toomey; Don Abel; Marco Lippi; Andrea Passerini; Paolo Frasconi; Stephen K Burley; Burkhard Rost; Mark R Chance
Characterization of metalloproteins by high-throughput X-ray absorption spectroscopy.
Genome research 2011;21(6):898-907.
2011: Wuxian Shi; Mark R Chance
Metalloproteomics: forward and reverse approaches in metalloprotein structural and functional characterization.
Current opinion in chemical biology 2011;15(1):144-8.
2010: Liwen Wang; Yali Qin; Serguei Ilchenko; Jen Bohon; Wuxian Shi; Michael W Cho; Keiji Takamoto; Mark R Chance
Structural analysis of a highly glycosylated and unliganded gp120-based antigen using mass spectrometry.
Biochemistry 2010;49(42):9032-45.
2010: Wuxian Shi; Jen Bohon; Dong P Han; Habtom Habte; Yali Qin; Michael W Cho; Mark R Chance
Structural characterization of HIV gp41 with the membrane-proximal external region.
The Journal of biological chemistry 2010;285(31):24290-8.
2010: Meng-Chiao Ho; Wuxian Shi; Agnes Rinaldo-Matthis; Peter C Tyler; Gary B Evans; Keith Clinch; Steven C Almo; Vern L Schramm
Four generations of transition-state analogues for human purine nucleoside phosphorylase.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):4805-12.
2009: John Jeff Alvarado; Anjana-Devi Nemkal; J Michael Sauder; Marijane Russell; Donna E Akiyoshi; Wuxian Shi; Steven C Almo; Louis M Weiss
Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470.
Molecular and biochemical parasitology 2009;168(2):158-67.
2008: Wuxian Shi; Mark R Chance
Metallomics and metalloproteomics.
Cellular and molecular life sciences : CMLS 2008;65(19):3040-8.
2007: Andrew S Murkin; Matthew R Birck; Agnes Rinaldo-Matthis; Wuxian Shi; Erika Taylor; Steven C Almo; Vern L Schramm
Neighboring group participation in the transition state of human purine nucleoside phosphorylase.
Biochemistry 2007;46(17):5038-49.
2007: Babu A Manjasetty; Wuxian Shi; Chenyang Zhan; András Fiser; Mark R Chance
A high-throughput approach to protein structure analysis.
Genetic engineering 2007;28():105-28.
2006: Vipender Singh; Wuxian Shi; Steven C Almo; Gary B Evans; Richard H Furneaux; Peter C Tyler; Gavin F Painter; Dirk H Lenz; Simon P H Mee; Renjian Zheng; Vern L Schramm
Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae.
Biochemistry 2006;45(43):12929-41.
2006: Wuxian Shi; Howard Robinson; Michael Sullivan; Don Abel; John Toomey; Lonny E Berman; Don Lynch; Gerd Rosenbaum; George Rakowsky; Larry Rock; Bill Nolan; Grace Shea-McCarthy; Dieter Schneider; Erik Johnson; Robert M Sweet; Mark R Chance
Beamline X29: a novel undulator source for X-ray crystallography.
Journal of synchrotron radiation 2006;13(Pt 5):365-72.
2005: Chenyang Zhan; Elena V Fedorov; Wuxian Shi; Udupi A Ramagopal; R Thirumuruhan; Babu A Manjasetty; Steven C Almo; András Fiser; Mark R Chance; Alexander A Fedorov
The ybeY protein from Escherichia coli is a metalloprotein.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 11):959-63.
2005: Wuxian Shi; Chenyang Zhan; Alexander Ignatov; Babu A Manjasetty; Nebojsa Marinkovic; Michael Sullivan; Raymond Huang; Mark R Chance
Metalloproteomics: high-throughput structural and functional annotation of proteins in structural genomics.
Structure (London, England : 1993) 2005;13(10):1473-86.
2005: Li-Min Ting; Wuxian Shi; Andrzej Lewandowicz; Vipender Singh; Agnes Mwakingwe; Matthew R Birck; Erika Taylor; Graham Bench; Dennis C Madrid; Peter C Tyler; Gary B Evans; Richard H Furneaux; Vern L Schramm; Kami Kim
Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins.
The Journal of biological chemistry 2005;280(10):9547-54.
2004: Michael G Klein; Wuxian Shi; Udupi A Ramagopal; Yiider Tseng; Denis Wirtz; David R Kovar; Christopher J Staiger; Steven C Almo
Structure of the actin crosslinking core of fimbrin.
Structure (London, England : 1993) 2004;12(6):999-1013.
2004: Wuxian Shi; Li-Min Ting; Gregory A Kicska; Andrzej Lewandowicz; Peter C Tyler; Gary B Evans; Richard H Furneaux; Kami Kim; Steven C Almo; Vern L Schramm
Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function.
The Journal of biological chemistry 2004;279(18):18103-6.
2004: Vipender Singh; Wuxian Shi; Gary B Evans; Peter C Tyler; Richard H Furneaux; Steven C Almo; Vern L Schramm
Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A.
Biochemistry 2004;43(1):9-18.
2003: Andrzej Lewandowicz; Wuxian Shi; Gary B Evans; Peter C Tyler; Richard H Furneaux; Luiz A Basso; Diogenes Santos; Steven C Almo; Vern L Schramm
Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase.
Biochemistry 2003;42(20):6057-66.
2002: Gregory A Kicska; Peter C Tyler; Gary B Evans; Richard H Furneaux; Wuxian Shi; Alexander A Fedorov; Andrzej Lewandowicz; Sean M Cahill; Steven C Almo; Vern L Schramm
Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase.
Biochemistry 2002;41(49):14489-98.
2002: Wuxian Shi; Anne E Sarver; Ching C Wang; Kelly S E Tanaka; Steven C Almo; Vern L Schramm
Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration.
The Journal of biological chemistry 2002;277(42):39981-8.
2002: David A Ostrov; Matthew M Roden; Wuxian Shi; Edith Palmieri; Gregory J Christianson; Lisa Mendoza; Gilbert Villaflor; Darcie Tilley; Nilabh Shastri; Howard Grey; Steven C Almo; Derry C Roopenian; Stanley G Nathenson
How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):283-9.
2001: Vern L Schramm; Wuxian Shi
Atomic motion in enzymatic reaction coordinates.
Current opinion in structural biology 2001;11(6):657-65.
2001: Wuxian Shi; Kelly S E Tanaka; TR Crother; Milton Taylor; Steven C Almo; Vern L Schramm
Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae.
Biochemistry 2001;40(36):10800-9.
2001: Wuxian Shi; Luiz A Basso; Diogenes Santos; Peter C Tyler; Richard H Furneaux; John S Blanchard; Steven C Almo; Vern L Schramm
Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces.
Biochemistry 2001;40(28):8204-15.
2001: Luiz A Basso; Diogenes Santos; Wuxian Shi; Richard H Furneaux; Peter C Tyler; Vern L Schramm; John S Blanchard
Purine nucleoside phosphorylase from Mycobacterium tuberculosis. Analysis of inhibition by a transition-state analogue and dissection by parts.
Biochemistry 2001;40(28):8196-203.
2001: Alexander A Fedorov; Wuxian Shi; Gregory A Kicska; Elena V Fedorov; Peter C Tyler; Richard H Furneaux; J C Hanson; Graeme J Gainsford; John Larese; Vern L Schramm; Steven C Almo
Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis.
Biochemistry 2001;40(4):853-60.
2000: David A Ostrov; Wuxian Shi; Jean-Claude D Schwartz; Steven C Almo; Stanley G Nathenson
Structure of murine CTLA-4 and its role in modulating T cell responsiveness.
Science (New York, N.Y.) 2000;290(5492):816-9.
2000: Wuxian Shi; N R Munagala; Ching C Wang; CM Li; Peter C Tyler; Richard H Furneaux; Charles Grubmeyer; Vern L Schramm; Steven C Almo
Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,).
Biochemistry 2000;39(23):6781-90.
1999: Wuxian Shi; CM Li; Peter C Tyler; Richard H Furneaux; Charles Grubmeyer; Vern L Schramm; Steven C Almo
The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor.
Nature structural biology 1999;6(6):588-93.