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Hiroshi Shibuya

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Toshiyasu Goto; Shun-Ichiro Iemura; Tohru Natsume; Atsushi Sato; Kiyotoshi Satoh; Shungo Adachi; Masahiro Shimizu; Hiroshi Shibuya
IQGAP1 Functions as a Modulator of Dishevelled Nuclear Localization in Wnt Signaling.
Atsushi Sato; Hiroshi Shibuya
WNK signaling is involved in neural development via Lhx8/Awh expression.
Toshiyasu Goto; Akimasa Fukui; Hiroshi Shibuya; Ray Keller; Makoto Asashima
Xenopus furry contributes to release of microRNA gene silencing.

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All Publications

2013: Toshiyasu Goto; Shun-Ichiro Iemura; Tohru Natsume; Atsushi Sato; Kiyotoshi Satoh; Shungo Adachi; Masahiro Shimizu; Hiroshi Shibuya
IQGAP1 Functions as a Modulator of Dishevelled Nuclear Localization in Wnt Signaling.
PloS one 2013;8(4):e60865.
2013: Atsushi Sato; Hiroshi Shibuya
WNK signaling is involved in neural development via Lhx8/Awh expression.
PloS one 2013;8(1):e55301.
2010: Toshiyasu Goto; Akimasa Fukui; Hiroshi Shibuya; Ray Keller; Makoto Asashima
Xenopus furry contributes to release of microRNA gene silencing.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(45):19344-9.
2010: Takeshi Maruyama; Hisae Kadowaki; Noriaki Okamoto; Atsushi Nagai; Isao Naguro; Atsushi Matsuzawa; Hiroshi Shibuya; Keiji Tanaka; Shigeo Murata; Kohsuke Takeda; Hideki Nishitoh; Hidenori Ichijo
CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.
The EMBO journal 2010;29(15):2501-14.
2010: Eriko Ohnishi; Toshiyasu Goto; Atsushi Sato; Mi-Sun Kim; Shun-ichiro Iemura; Tohru Ishitani; Tohru Natsume; Junji Ohnishi; Hiroshi Shibuya
Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase.
Molecular and cellular biology 2010;30(3):675-83.
2008: Hidemitsu Tsutsui; Jitsuo Usuda; Mitsuhiro Kubota; Masae Yamada; Akihiko Suzuki; Hiroshi Shibuya; Kuniharu Miyajima; Koichi Tanaka; Kiminori Sugino; Koichi Ito; Harubumi Kato
Endoscopic tumor ablation for laryngotracheal intraluminal invasion secondary to advanced thyroid cancer.
Acta oto-laryngologica 2008;128(7):799-807.
2008: Naoki Hisamoto; Tetsuo Moriguchi; Seiichi Urushiyama; Shohei Mitani; Hiroshi Shibuya; Kunihiro Matsumoto
Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.
EMBO reports 2008;9(1):70-5.
2007: Kiyotoshi Satoh; Junji Ohnishi; Atsushi Sato; Michio Takeyama; Shun-ichiro Iemura; Tohru Natsume; Hiroshi Shibuya
Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development.
Molecular and cellular biology 2007;27(21):7623-30.
2007: Yosuke Matsubara; Ichiro Kawasaki; Seiichi Urushiyama; Tomoharu Yasuda; Masaki Shirakata; Yuichi Iino; Hiroshi Shibuya; Yuji Yamanashi
The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(3):407-20.
2006: Misato Yamada; Junji Ohnishi; Bisei Ohkawara; Shun-ichiro Iemura; Kiyotoshi Satoh; Junko Hyodo-Miura; Kaoru Kawachi; Tohru Natsume; Hiroshi Shibuya
NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF).
The Journal of biological chemistry 2006;281(30):20749-60.
2006: Miyuki Honma; Osamu Higuchi; Masaki Shirakata; Tomoharu Yasuda; Hiroshi Shibuya; Shun-ichiro Iemura; Tohru Natsume; Yuji Yamanashi
Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases.
Genes to cells : devoted to molecular & cellular mechanisms 2006;11(2):143-51.
2005: Tetsuo Moriguchi; Seiichi Urushiyama; Naoki Hisamoto; Shun-ichiro Iemura; Shinichi Uchida; Tohru Natsume; Kunihiro Matsumoto; Hiroshi Shibuya
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.
The Journal of biological chemistry 2005;280(52):42685-93.
2005: Junji Ohnishi; Eriko Ohnishi; Hiroshi Shibuya; Takayuki Takahashi
Functions for proteinases in the ovulatory process.
Biochimica et biophysica acta 2005;1751(1):95-109.
2004: Shungo Adachi; Takafumi Jigami; Toshio Yasui; Tetsuhiro Nakano; Susumu Ohwada; Yoshihiro Omori; Sumio Sugano; Bisei Ohkawara; Hiroshi Shibuya; Tsutomu Nakamura; Tetsu Akiyama
Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling.
Cancer research 2004;64(23):8496-501.
2004: Yukako Aoyama; Seiichi Urushiyama; Misato Yamada; Chikako Kato; Hiroko Ide; Satoshi Higuchi; Tetsu Akiyama; Hiroshi Shibuya
MFB-1, an F-box-type ubiquitin ligase, regulates TGF-beta signalling.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(11):1093-101.
2004: Michiko Muraki; Bisei Ohkawara; Takamitsu Hosoya; Hiroshi Onogi; Jun Koizumi; Tomonobu Koizumi; Koichi Sumi; Jun-ichiro Yomoda; Michael V Murray; Hiroshi Kimura; Kiyoshi Furuichi; Hiroshi Shibuya; Adrian R Krainer; Masaaki Suzuki; Masatoshi Hagiwara
Manipulation of alternative splicing by a newly developed inhibitor of Clks.
The Journal of biological chemistry 2004;279(23):24246-54.
2004: Bisei Ohkawara; Kyoko Shirakabe; Junko Hyodo-Miura; Ritsuko Matsuo; Naoto Ueno; Kunihiro Matsumoto; Hiroshi Shibuya
Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction.
Genes & development 2004;18(4):381-6.
2003: Tohru Ishitani; Giichi Takaesu; Jun Ninomiya-Tsuji; Hiroshi Shibuya; Richard B Gaynor; Kunihiro Matsumoto
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.
The EMBO journal 2003;22(23):6277-88.
2003: Misato Yamada; Bisei Ohkawara; Naoya Ichimura; Junko Hyodo-Miura; Seiichi Urushiyama; Kyoko Shirakabe; Hiroshi Shibuya
Negative regulation of Wnt signalling by HMG2L1, a novel NLK-binding protein.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(8):677-84.
2003: Isao Oishi; Hiroaki Suzuki; Nobuyuki Onishi; Ritsuko Takada; Shuichi Kani; Bisei Ohkawara; Ikue Koshida; Kentaro Suzuki; General Yamada; Georg C Schwabe; Stefan Mundlos; Hiroshi Shibuya; Shinji Takada; Yasuhiro Minami
The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(7):645-54.
2003: Tohru Ishitani; Satoshi Kishida; Junko Hyodo-Miura; Naoto Ueno; Jun Yasuda; Marian Waterman; Hiroshi Shibuya; Randall T Moon; Jun Ninomiya-Tsuji; Kunihiro Matsumoto
The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling.
Molecular and cellular biology 2003;23(1):131-9.
2002: Junko Hyodo-Miura; Seiichi Urushiyama; Shin-ichi Nagai; Michiru Nishita; Naoto Ueno; Hiroshi Shibuya
Involvement of NLK and Sox11 in neural induction in Xenopus development.
Genes to cells : devoted to molecular & cellular mechanisms 2002;7(5):487-96.
2001: K Shirakabe; Kazuya Terasawa; K Miyama; Hiroshi Shibuya; Eisuke Nishida
Regulation of the activity of the transcription factor Runx2 by two homeobox proteins, Msx2 and Dlx5.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(10):851-6.
2001: K Sugawara; K Morita; Naoto Ueno; Hiroshi Shibuya
BIP, a BRAM-interacting protein involved in TGF-beta signalling, regulates body length in Caenorhabditis elegans.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(7):599-606.
2000: K Tago; Tsutomu Nakamura; M Nishita; J Hyodo; S Nagai; Y Murata; S Adachi; Susumu Ohwada; Yasuyuki Morishita; Hiroshi Shibuya; Tetsu Akiyama
Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein.
Genes & development 2000;14(14):1741-9.
2000: Hiroshi Hanafusa; Norihisa Masuyama; Morioh Kusakabe; Hiroshi Shibuya; Eisuke Nishida
The TGF-beta family member derrière is involved in regulation of the establishment of left-right asymmetry.
EMBO reports 2000;1(1):32-9.
2000: N Kimura; R Matsuo; Hiroshi Shibuya; K Nakashima; Tetsuya Taga
BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6.
The Journal of biological chemistry 2000;275(23):17647-52.
2000: Y Takatsu; M Nakamura; M Stapleton; M C Danos; K Matsumoto; M B O'Connor; Hiroshi Shibuya; Naoto Ueno
TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development.
Molecular and cellular biology 2000;20(9):3015-26.
2000: Giichi Takaesu; Satoshi Kishida; A Hiyama; K Yamaguchi; Hiroshi Shibuya; Kenji Irie; Jun Ninomiya-Tsuji; Kunihiro Matsumoto
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.
Molecular cell 2000;5(4):649-58.
1999: M Nishita; Naoto Ueno; Hiroshi Shibuya
Smad8B, a Smad8 splice variant lacking the SSXS site that inhibits Smad8-mediated signalling.
Genes to cells : devoted to molecular & cellular mechanisms 1999;4(10):583-91.
1999: Hiroshi Hanafusa; Jun Ninomiya-Tsuji; Norihisa Masuyama; M Nishita; J Fujisawa; Hiroshi Shibuya; Kunihiro Matsumoto; Eisuke Nishida
Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression.
The Journal of biological chemistry 1999;274(38):27161-7.
1999: Tohru Ishitani; Jun Ninomiya-Tsuji; S Nagai; M Nishita; MD Meneghini; Nick Barker; M Waterman; Bruce Bowerman; H Clevers; Hiroshi Shibuya; Kunihiro Matsumoto
The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.
Nature 1999;399(6738):798-802.
1999: Norihisa Masuyama; Hiroshi Hanafusa; Morioh Kusakabe; Hiroshi Shibuya; Eisuke Nishida
Identification of two Smad4 proteins in Xenopus. Their common and distinct properties.
The Journal of biological chemistry 1999;274(17):12163-70.
1999: K Yamaguchi; S Nagai; Jun Ninomiya-Tsuji; M Nishita; Katsuyuki Tamai; Kenji Irie; Naoto Ueno; Eisuke Nishida; Hiroshi Shibuya; Kunihiro Matsumoto
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway.
The EMBO journal 1999;18(1):179-87.
1998: Hiroshi Shibuya; H Iwata; N Masuyama; Y Gotoh; K Yamaguchi; K Irie; K Matsumoto; E Nishida; Naoto Ueno
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development.
The EMBO journal 1998;17(4):1019-28.
1997: K Shirakabe; K Yamaguchi; Hiroshi Shibuya; Kazuhiro Irie; S Matsuda; Tetsuo Moriguchi; Y Gotoh; Kunihiro Matsumoto; Eisuke Nishida
TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase.
The Journal of biological chemistry 1997;272(13):8141-4.
1996: Tetsuo Moriguchi; N Kuroyanagi; K Yamaguchi; Y Gotoh; K Irie; T Kano; K Shirakabe; Y Muro; Hiroshi Shibuya; K Matsumoto; Eisuke Nishida; M Hagiwara
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3.
The Journal of biological chemistry 1996;271(23):13675-9.
1995: K Yamaguchi; K Shirakabe; Hiroshi Shibuya; Kenji Irie; I Oishi; N Ueno; T Taniguchi; Eisuke Nishida; K Matsumoto
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction.
Science (New York, N.Y.) 1995;270(5244):2008-11.