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Masabumi Shibuya

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Chemicals & Drugs

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Neovascularization, Pathologic

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Shoji P Ohuchi; Masabumi Shibuya; Yoshikazu Nakamura
The RNA aptamer inhibiting human vesicular endothelial growth factor receptor 1 without affecting cytokine binding.
Saeed Samarghandian; Masabumi Shibuya
Vascular Endothelial Growth Factor Receptor Family in Ascidians, Halocynthia roretzi (Sea Squirt). Its High Expression in Circulatory System-Containing Tissues.
Michiko Murohashi; Takahisa Nakamura; Satoshi Tanaka; T Ichise; Nobuaki Yoshida; Tadashi Yamamoto; Masabumi Shibuya; Joseph Schlessinger; Noriko Gotoh
An FGF4-FRS2alpha-Cdx2 axis in trophoblast stem cells induces Bmp4 to regulate proper growth of early mouse embryos.

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All Publications

2013: Shoji P Ohuchi; Masabumi Shibuya; Yoshikazu Nakamura
The RNA aptamer inhibiting human vesicular endothelial growth factor receptor 1 without affecting cytokine binding.
Biochemistry 2013;52(13):2274-9.
2013: Saeed Samarghandian; Masabumi Shibuya
Vascular Endothelial Growth Factor Receptor Family in Ascidians, Halocynthia roretzi (Sea Squirt). Its High Expression in Circulatory System-Containing Tissues.
International journal of molecular sciences 2013;14(3):4841-53.
2010: Michiko Murohashi; Takahisa Nakamura; Satoshi Tanaka; T Ichise; Nobuaki Yoshida; Tadashi Yamamoto; Masabumi Shibuya; Joseph Schlessinger; Noriko Gotoh
An FGF4-FRS2alpha-Cdx2 axis in trophoblast stem cells induces Bmp4 to regulate proper growth of early mouse embryos.
Stem cells (Dayton, Ohio) 2010;28(1):113-21.
2008: Sachie Hiratsuka; Akira Watanabe; Yoshiko Sakurai; Sachiko Akashi-Takamura; Sachie Ishibashi; Kensuke Miyake; Masabumi Shibuya; Shizuo Akira; Hiroyuki Aburatani; Yoshiro Maru
The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase.
Nature cell biology 2008;10(11):1349-55.
2008: Masato Murakami; Yujuan Zheng; Masanori Hirashima; Toshio Suda; Yohei Morita; Jun Ooehara; Hideo Ema; Guo-Hua Fong; Masabumi Shibuya
VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(4):658-64.
2008: Junko Kami; Kimimasa Muranaka; Yasuo Yanagi; Ryo Obata; Yasuhiro Tamaki; Masabumi Shibuya
Inhibition of choroidal neovascularization by blocking vascular endothelial growth factor receptor tyrosine kinase.
Japanese journal of ophthalmology 2008;52(2):91-8.
2007: Masaki Kunizaki; Ryuji Hamamoto; Fábio Pittella Silva; Kiyoshi Yamaguchi; Takeshi Nagayasu; Masabumi Shibuya; Yusuke Nakamura; Yoichi Furukawa
The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3.
Cancer research 2007;67(22):10759-65.
2007: Mai Yamauchi; Shinobu Imajoh-Ohmi; Masabumi Shibuya
Novel antiangiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle.
Cancer science 2007;98(9):1491-7.
2007: Yujuan Zheng; Makoto Watanabe; Takeshi Kuraishi; Shosaku Hattori; Chieko Kai; Masabumi Shibuya
Chimeric VEGF-ENZ7/PlGF specifically binding to VEGFR-2 accelerates skin wound healing via enhancement of neovascularization.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(3):503-11.
2006: Mari Kiyono; Masabumi Shibuya
Inhibitory Smad transcription factors protect arterial endothelial cells from apoptosis induced by BMP4.
Oncogene 2006;25(54):7131-7.
2006: Hidenobu Ishizaki; Tatsuhiko Tsunoda; Satoshi Wada; Mai Yamauchi; Masabumi Shibuya; Hideaki Tahara
Inhibition of tumor growth with antiangiogenic cancer vaccine using epitope peptides derived from human vascular endothelial growth factor receptor 1.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5841-9.
2006: Hiroyuki Nakamura; Yusuke Sasaki; Masaharu Uno; Tomohiro Yoshikawa; Toru Asano; Hyun Seung Ban; Hidesuke Fukazawa; Masabumi Shibuya; Yoshimasa Uehara
Synthesis and biological evaluation of benzamides and benzamidines as selective inhibitors of VEGFR tyrosine kinases.
Bioorganic & medicinal chemistry letters 2006;16(19):5127-31.
2006: Masabumi Shibuya
Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis.
Journal of biochemistry and molecular biology 2006;39(5):469-78.
2006: Masato Murakami; Shinobu Iwai; Sachie Hiratsuka; Mai Yamauchi; Kazuhide Nakamura; Yoichiro Iwakura; Masabumi Shibuya
Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages.
Blood 2006;108(6):1849-56.
2006: Yujuan Zheng; Masato Murakami; Hiroyuki Takahashi; Mai Yamauchi; Atsushi Kiba; Sachiko Yamaguchi; Naoyuki Yabana; Kari Alitalo; Masabumi Shibuya
Chimeric VEGF-E(NZ7)/PlGF promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(9):2019-26.
2006: Masabumi Shibuya; Lena Claesson-Welsh
Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis.
Experimental cell research 2006;312(5):549-60.
2006: Masabumi Shibuya
Vascular endothelial growth factor (VEGF)-Receptor2: its biological functions, major signaling pathway, and specific ligand VEGF-E.
Endothelium : journal of endothelial cell research 2006;13(2):63-9.
2005: S Yamamoto; I Yoshino; T Shimazaki; M Murohashi; Robert Hevner; Irit Lax; Hideyuki Okano; Masabumi Shibuya; Joseph Schlessinger; Noriko Gotoh
Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15983-8.
2005: Hiroyuki Takahashi; Masabumi Shibuya
The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions.
Clinical science (London, England : 1979) 2005;109(3):227-41.
2005: Moritoshi Sato; Yoshibumi Ueda; Masabumi Shibuya; Yoshio Umezawa
Locating inositol 1,4,5-trisphosphate in the nucleus and neuronal dendrites with genetically encoded fluorescent indicators.
Analytical chemistry 2005;77(15):4751-8.
2005: Satoshi Wada; Tatsuhiko Tsunoda; Toshiyuki Baba; F James Primus; Hiroyuki Kuwano; Masabumi Shibuya; Hideaki Tahara
Rationale for antiangiogenic cancer therapy with vaccination using epitope peptides derived from human vascular endothelial growth factor receptor 2.
Cancer research 2005;65(11):4939-46.
2005: Yoshiko Sakurai; Kaori Ohgimoto; Yuki Kataoka; Nobuaki Yoshida; Masabumi Shibuya
Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(4):1076-81.
2005: Sachie Hiratsuka; Yuki Kataoka; Kazuki Nakao; Kenji Nakamura; Shunichi Morikawa; Satoshi Tanaka; Motoya Katsuki; Yoshiro Maru; Masabumi Shibuya
Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos.
Molecular and cellular biology 2005;25(1):355-63.
2005: Sachie Hiratsuka; Kazuki Nakao; Kenji Nakamura; Motoya Katsuki; Yoshiro Maru; Masabumi Shibuya
Membrane fixation of vascular endothelial growth factor receptor 1 ligand-binding domain is important for vasculogenesis and angiogenesis in mice.
Molecular and cellular biology 2005;25(1):346-54.
2004: Masabumi Shibuya
[Regulation of angiogenesis by VEGF signaling].
Seikagaku. The Journal of Japanese Biochemical Society 2004;76(12):1534-42.
2004: Satsuki Kobayashi; Yoshihisa Nojima; Masabumi Shibuya; Yoshiro Maru
Nox1 regulates apoptosis and potentially stimulates branching morphogenesis in sinusoidal endothelial cells.
Experimental cell research 2004;300(2):455-62.
2004: Hiroyuki Takahashi; Shosaku Hattori; Akihiro Iwamatsu; Hajime Takizawa; Masabumi Shibuya
A novel snake venom vascular endothelial growth factor (VEGF) predominantly induces vascular permeability through preferential signaling via VEGF receptor-1.
The Journal of biological chemistry 2004;279(44):46304-14.
2004: Satsuki Kobayashi; Emi Ito; Reiko Honma; Yoshihisa Nojima; Masabumi Shibuya; Shinya Watanabe; Yoshiro Maru
Dynamic regulation of gene expression by the Flt-1 kinase and Matrigel in endothelial tubulogenesis.
Genomics 2004;84(1):185-92.
2004: Satsuki Kobayashi; Asako Sawano; Yoshihisa Nojima; Masabumi Shibuya; Yoshiro Maru
The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(7):929-31.
2003: Masabumi Shibuya
VEGF-receptor inhibitors for anti-angiogenesis.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122(6):498-503.
2003: Momomi Saito; Maho Hamasaki; Masabumi Shibuya
Induction of tube formation by angiopoietin-1 in endothelial cell/fibroblast co-culture is dependent on endogenous VEGF.
Cancer science 2003;94(9):782-90.
2003: Masabumi Shibuya
Vascular endothelial growth factor receptor-2: its unique signaling and specific ligand, VEGF-E.
Cancer science 2003;94(9):751-6.
2003: Ken Murata; Hidetoshi Kumagai; Toshiyuki Kawashima; Kaori Tamitsu; Mariko Irie; Hideaki Nakajima; Shinya Suzu; Masabumi Shibuya; Shimeru Kamihira; Tetsuya Nosaka; Shigetaka Asano; Toshio Kitamura
Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3).
The Journal of biological chemistry 2003;278(35):32892-8.
2003: Mari Kiyono; Masabumi Shibuya
Bone morphogenetic protein 4 mediates apoptosis of capillary endothelial cells during rat pupillary membrane regression.
Molecular and cellular biology 2003;23(13):4627-36.
2003: Atsushi Kiba; Naoyuki Yabana; Masabumi Shibuya
A set of loop-1 and -3 structures in the novel vascular endothelial growth factor (VEGF) family member, VEGF-ENZ-7, is essential for the activation of VEGFR-2 signaling.
The Journal of biological chemistry 2003;278(15):13453-61.
2003: Atsushi Kiba; Hiroshi Sagara; Takeshi Hara; Masabumi Shibuya
VEGFR-2-specific ligand VEGF-E induces non-edematous hyper-vascularization in mice.
Biochemical and biophysical research communications 2003;301(2):371-7.
2002: Masabumi Shibuya
[Angiogenesis, anti-angiogenesis, and tumor suppression].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2002;120(5):285-94.
2002: Naoyuki Yabana; Masabumi Shibuya
Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.
Oncogene 2002;21(50):7720-9.
2002: Masabumi Shibuya
Vascular endothelial growth factor receptor family genes: when did the three genes phylogenetically segregate?
Biological chemistry 2002;383(10):1573-9.
2002: Sachie Hiratsuka; Kazuhiro Nakamura; Shinobu Iwai; Masato Murakami; Takeshi Itoh; Hiroshi Kijima; J Michael Shipley; Robert M Senior; Masabumi Shibuya
MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis.
Cancer cell 2002;2(4):289-300.
2002: Sachiko Yamaguchi; Kumi Iwata; Masabumi Shibuya
Soluble Flt-1 (soluble VEGFR-1), a potent natural antiangiogenic molecule in mammals, is phylogenetically conserved in avians.
Biochemical and biophysical research communications 2002;291(3):554-9.
2001: Yoshiro Maru; E Bergmann; Frédéric Coin; Jean-Marc Egly; Masabumi Shibuya
TFIIH functions are altered by the P210BCR-ABL oncoprotein produced on the Philadelphia chromosome.
Mutation research 2001;483(1-2):83-8.
2001: Y Onishi-Haraikawa; Masako Funaki; N Gotoh; Masabumi Shibuya; Kouichi Inukai; Hideki Katagiri; Yasushi Fukushima; Motonobu Anai; Toshio Ogihara; Hideyuki Sakoda; Hiraku Ono; Masatoshi Kikuchi; Yoshitaka Oka; Tomoichiro Asano
Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein.
Biochemical and biophysical research communications 2001;288(2):476-82.
2001: Y Kin; G Li; Masabumi Shibuya; Yoshiro Maru
The Dbl homology domain of BCR is not a simple spacer in P210BCR-ABL of the Philadelphia chromosome.
The Journal of biological chemistry 2001;276(42):39462-8.
2001: Y Kin; Masabumi Shibuya; Yoshiro Maru
A suppressive effect of an Epstein-Barr virus-immortalized cell line on leukemic cells.
Clinical biochemistry 2001;34(6):507-10.
2001: Y Kin; Masabumi Shibuya; Yoshiro Maru
Inhibition of protein kinase C delta has negative effect on anchorage-independent growth of BCR-ABL-transformed Rat1 cells.
Leukemia research 2001;25(9):821-5.
2001: Yoshiro Maru; S K Hanks; Masabumi Shibuya
The tubulogenic activity associated with an activated form of Flt-1 kinase is dependent on focal adhesion kinase.
Biochimica et biophysica acta 2001;1540(2):147-53.
2001: Tokiharu Takahashi; Sachiko Yamaguchi; K Chida; Masabumi Shibuya
A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells.
The EMBO journal 2001;20(11):2768-78.
2001: Masabumi Shibuya
Structure and dual function of vascular endothelial growth factor receptor-1 (Flt-1).
The international journal of biochemistry & cell biology 2001;33(4):409-20.
2001: J C Luo; Masabumi Shibuya
A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha).
Oncogene 2001;20(12):1435-44.
2001: Masabumi Shibuya
Structure and function of VEGF/VEGF-receptor system involved in angiogenesis.
Cell structure and function 2001;26(1):25-35.
2001: Sachie Hiratsuka; Yoshiro Maru; A Okada; Motoharu Seiki; Tetsuo Noda; Masabumi Shibuya
Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis.
Cancer research 2001;61(3):1207-13.
2001: Asako Sawano; Shinobu Iwai; Y Sakurai; Mamoru Ito; Kenya Shitara; Tatsutoshi Nakahata; Masabumi Shibuya
Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans.
Blood 2001;97(3):785-91.
2001: Tokiharu Takahashi; Masabumi Shibuya
The overexpression of PKCdelta is involved in vascular endothelial growth factor-resistant apoptosis in cultured primary sinusoidal endothelial cells.
Biochemical and biophysical research communications 2001;280(1):415-20.
2000: Masabumi Shibuya
[Anti-angiogenic reagents].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(6 Suppl):1182-7.
2000: Yoshiro Maru; H Hirosawa; Masabumi Shibuya
An oncogenic form of the Flt-1 kinase has a tubulogenic potential in a sinusoidal endothelial cell line.
European journal of cell biology 2000;79(2):130-43.
1999: K Wakiya; Masabumi Shibuya
Okadaic acid stimulates the expression of vascular endothelial growth factor gene.
Biochemical and biophysical research communications 1999;265(2):584-8.
1999: Yoshiro Maru; Takakazu Kobayashi; Keiichi Tanaka; Masabumi Shibuya
BCR binds to the xeroderma pigmentosum group B protein.
Biochemical and biophysical research communications 1999;260(2):309-12.
1999: Tokiharu Takahashi; Hiroo Ueno; Masabumi Shibuya
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells.
Oncogene 1999;18(13):2221-30.
1999: Masabumi Shibuya
[Angiogenesis--vascular endothelial growth factor and its receptors].
Human cell 1999;12(1):17-24.
1999: Yoshinori Seko; Y Seko; N Takahashi; Masabumi Shibuya; Yoshio Yazaki
Pulsatile stretch stimulates vascular endothelial growth factor (VEGF) secretion by cultured rat cardiac myocytes.
Biochemical and biophysical research communications 1999;254(2):462-5.
1999: N Takeda; Masabumi Shibuya; Yoshiro Maru
The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):203-7.
1999: Masabumi Shibuya; JC Luo; M Toyoda; Sachiko Yamaguchi
Involvement of VEGF and its receptors in ascites tumor formation.
Cancer chemotherapy and pharmacology 1999;43 Suppl():S72-7.
1999: Masabumi Shibuya; N Ito; Lena Claesson-Welsh
Structure and function of vascular endothelial growth factor receptor-1 and -2.
Current topics in microbiology and immunology 1999;237():59-83.
1998: Akeo Shinkai; M Ito; Hideharu Anazawa; Sachiko Yamaguchi; Kenya Shitara; Masabumi Shibuya
Mapping of the sites involved in ligand association and dissociation at the extracellular domain of the kinase insert domain-containing receptor for vascular endothelial growth factor.
The Journal of biological chemistry 1998;273(47):31283-8.
1998: Seishi Ogawa; Akira Oku; Asako Sawano; Sachiko Yamaguchi; Yoshio Yazaki; Masabumi Shibuya
A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain.
The Journal of biological chemistry 1998;273(47):31273-82.
1998: M Toyoda; N Gotoh; H Handa; Masabumi Shibuya
Involvement of MAP kinase-independent protein kinase C signaling pathway in the EGF-induced p21(WAF1/Cip1) expression and growth inhibition of A431 cells.
Biochemical and biophysical research communications 1998;250(2):430-5.
1998: Sachie Hiratsuka; Osamu Minowa; Junko Kuno; Tetsuo Noda; Masabumi Shibuya
Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9349-54.
1998: Yoshiro Maru; Sachiko Yamaguchi; Tokiharu Takahashi; Hiroo Ueno; Masabumi Shibuya
Virally activated Ras cooperates with integrin to induce tubulogenesis in sinusoidal endothelial cell lines.
Journal of cellular physiology 1998;176(2):223-34.
1998: JC Luo; Sachiko Yamaguchi; Akeo Shinkai; Kenya Shitara; Masabumi Shibuya
Significant expression of vascular endothelial growth factor/vascular permeability factor in mouse ascites tumors.
Cancer research 1998;58(12):2652-60.
1998: JC Luo; M Toyoda; Masabumi Shibuya
Differential inhibition of fluid accumulation and tumor growth in two mouse ascites tumors by an antivascular endothelial growth factor/permeability factor neutralizing antibody.
Cancer research 1998;58(12):2594-600.
1998: Yoshiro Maru; Sachiko Yamaguchi; Masabumi Shibuya
Flt-1, a receptor for vascular endothelial growth factor, has transforming and morphogenic potentials.
Oncogene 1998;16(20):2585-95.
1998: K Kondo; Sachie Hiratsuka; E Subbalakshmi; H Matsushime; Masabumi Shibuya
Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors.
Gene 1998;208(2):297-305.
1997: H Miura; T Miyazaki; M Kuroda; T Oka; Rikuo Machinami; Tsunenori Kodama; Masabumi Shibuya; Makuuchi Masatoshi; Yoshio Yazaki; S Ohnishi
Increased expression of vascular endothelial growth factor in human hepatocellular carcinoma.
Journal of hepatology 1997;27(5):854-61.
1997: Asako Sawano; Tokiharu Takahashi; Sachiko Yamaguchi; Masabumi Shibuya
The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma.
Biochemical and biophysical research communications 1997;238(2):487-91.
1997: Keiichi Tanaka; Sachiko Yamaguchi; Asako Sawano; Masabumi Shibuya
Characterization of the extracellular domain in vascular endothelial growth factor receptor-1 (Flt-1 tyrosine kinase).
Japanese journal of cancer research : Gann 1997;88(9):867-76.
1997: Masabumi Shibuya
[Tumor angiogenesis and Flt tyrosine kinase].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(10 Suppl):1470-6.
1997: Tokiharu Takahashi; Masabumi Shibuya
The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts.
Oncogene 1997;14(17):2079-89.
1997: Noriko Gotoh; M Toyoda; Masabumi Shibuya
Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation.
Molecular and cellular biology 1997;17(4):1824-31.