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Hisayuki Shigematsu

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Makoto Suzuki; Hironobu Wada; Mitsuru Yoshino; Lei Tian; Hisayuki Shigematsu; Hidemi Suzuki; Mahmoud Alaa; Hajime Tamura; Taiki Fujiwara; Kaoru Nagato; Shinichiro Motohashi; Yasumitsu Moriya; Hidehisa Hoshino; Shigetoshi Yoshida; Kiyoshi Shibuya; Kenzo Hiroshima; Yukio Nakatani; Ichiro Yoshino
Molecular characterization of chronic obstructive pulmonary disease-related non-small cell lung cancer through aberrant methylation and alterations of EGFR signaling.
Junichi Soh; Naoki Okumura; William W Lockwood; Hiromasa Yamamoto; Hisayuki Shigematsu; Wei Zhang; Raj Chari; David S Shames; Ximing Tang; Calum MacAulay; Marileila Varella-Garcia; Tõnu Vooder; Ignacio I Wistuba; Stephen Lam; Rolf Brekken; Shinichi Toyooka; John D Minna; Wan L Lam; Adi F Gazdar
Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.
Jeet Gandhi; Jianling Zhang; Yang Xie; Junichi Soh; Hisayuki Shigematsu; Wei Zhang; Hiromasa Yamamoto; Michael Peyton; Luc Girard; William W Lockwood; Wan L Lam; Marileila Varella-Garcia; John D Minna; Adi F Gazdar
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.

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All Publications

2010: Makoto Suzuki; Hironobu Wada; Mitsuru Yoshino; Lei Tian; Hisayuki Shigematsu; Hidemi Suzuki; Mahmoud Alaa; Hajime Tamura; Taiki Fujiwara; Kaoru Nagato; Shinichiro Motohashi; Yasumitsu Moriya; Hidehisa Hoshino; Shigetoshi Yoshida; Kiyoshi Shibuya; Kenzo Hiroshima; Yukio Nakatani; Ichiro Yoshino
Molecular characterization of chronic obstructive pulmonary disease-related non-small cell lung cancer through aberrant methylation and alterations of EGFR signaling.
Annals of surgical oncology 2010;17(3):878-88.
2009: Junichi Soh; Naoki Okumura; William W Lockwood; Hiromasa Yamamoto; Hisayuki Shigematsu; Wei Zhang; Raj Chari; David S Shames; Ximing Tang; Calum MacAulay; Marileila Varella-Garcia; Tõnu Vooder; Ignacio I Wistuba; Stephen Lam; Rolf Brekken; Shinichi Toyooka; John D Minna; Wan L Lam; Adi F Gazdar
Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.
PloS one 2009;4(10):e7464.
2009: Jeet Gandhi; Jianling Zhang; Yang Xie; Junichi Soh; Hisayuki Shigematsu; Wei Zhang; Hiromasa Yamamoto; Michael Peyton; Luc Girard; William W Lockwood; Wan L Lam; Marileila Varella-Garcia; John D Minna; Adi F Gazdar
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.
PloS one 2009;4(2):e4576.
2008: Hiromasa Yamamoto; Hisayuki Shigematsu; Masaharu Nomura; William W Lockwood; Mitsuo Sato; Naoki Okumura; Junichi Soh; Makoto Suzuki; Ignacio I Wistuba; Kwun M Fong; Huei Lee; Shinichi Toyooka; Hiroshi Date; Wan L Lam; John D Minna; Adi F Gazdar
PIK3CA mutations and copy number gains in human lung cancers.
Cancer research 2008;68(17):6913-21.
2008: Shawna L Bull Phelps; John O Schorge; Michael J Peyton; Hisayuki Shigematsu; Li-Lin Xiang; David S Miller; Jayanthi S Lea
Implications of EGFR inhibition in ovarian cancer cell proliferation.
Gynecologic oncology 2008;109(3):411-7.
2007: Makoto Suzuki; Hisayuki Shigematsu; Takahiro Nakajima; Rieko Kubo; Shinichiro Motohashi; Yasuo Sekine; Kiyoshi Shibuya; Toshihiko Iizasa; Kenzo Hiroshima; Yukio Nakatani; Adi F Gazdar; Takehiko Fujisawa
Synchronous alterations of Wnt and epidermal growth factor receptor signaling pathways through aberrant methylation and mutation in non small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(20):6087-92.
2007: Masaharu Nomura; Hisayuki Shigematsu; Lin Li; Makoto Suzuki; Takao Takahashi; Pila Estess; Mark Siegelman; Ziding Feng; Harubumi Kato; Antonio Marchetti; Jerry W Shay; Margaret R Spitz; Ignacio I Wistuba; John D Minna; Adi F Gazdar
Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers.
PLoS medicine 2007;4(4):e125.
2007: Makoto Suzuki; Hisayuki Shigematsu; David Shames; noriaki sunaga; Takao Takahashi; Narayan Shivapurkar; Toshihiko Iizasa; John D Minna; Takehiko Fujisawa; Adi F Gazdar
Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers.
Annals of surgical oncology 2007;14(4):1397-404.
2006: Makoto Suzuki; Hisayuki Shigematsu; Narayan Shivapurkar; Jyotsna Reddy; Kuniharu Miyajima; Takao Takahashi; Adi F Gazdar; Eugene P Frenkel
Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer.
Cancer letters 2006;242(2):222-30.
2006: Makoto Suzuki; Hisayuki Shigematsu; Toshihiko Iizasa; Kenzo Hiroshima; Yukio Nakatani; John D Minna; Adi F Gazdar; Takehiko Fujisawa
Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer.
Cancer 2006;106(10):2200-7.
2006: Takao Takahashi; Hisayuki Shigematsu; Narayan Shivapurkar; Jyotsna Reddy; Yingye Zheng; Ziding Feng; Makoto Suzuki; Masaharu Nomura; Meena Augustus; Jing Yin; Meltzer Stephen J.; Adi F Gazdar
Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers.
International journal of cancer. Journal international du cancer 2006;118(4):924-31.
2006: Hisayuki Shigematsu; Adi F Gazdar
Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers.
International journal of cancer. Journal international du cancer 2006;118(2):257-62.
2005: Makoto Suzuki; Hong Chen; Hisayuki Shigematsu; Soichiro Ando; Tomohiko Iida; Takahiro Nakajima; Takehiko Fujisawa; Hideki Kimura
Aberrant methylation: common in thymic carcinomas, rare in thymomas.
Oncology reports 2005;14(6):1621-4.
2005: Makoto Suzuki; Hisayuki Shigematsu; David Shames; noriaki sunaga; T Takahashi; Narayan Shivapurkar; Toshihiko Iizasa; Eugene P Frenkel; John D Minna; Takehiko Fujisawa; Adi F Gazdar
DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers.
British journal of cancer 2005;93(9):1029-37.
2005: Makoto Suzuki; Hisayuki Shigematsu; Kenzo Hiroshima; Toshihiko Iizasa; Yukio Nakatani; John D Minna; Adi F Gazdar; Takehiko Fujisawa
Epidermal growth factor receptor expression status in lung cancer correlates with its mutation.
Human pathology 2005;36(10):1127-34.
2005: Takao Takahashi; Makoto Suzuki; Hisayuki Shigematsu; Narayan Shivapurkar; Chinyere Echebiri; Masaharu Nomura; Victor Stastny; Meena Augustus; Cheng-Wen Wu; Ignacio I Wistuba; Meltzer Stephen J.; Adi F Gazdar
Aberrant methylation of Reprimo in human malignancies.
International journal of cancer. Journal international du cancer 2005;115(4):503-10.
2005: Makoto Suzuki; C Hao; T Takahashi; Hisayuki Shigematsu; Narayan Shivapurkar; Ubaradka G Sathyanarayana; Toshihiko Iizasa; Takehiko Fujisawa; K Hiroshima; Adi F Gazdar
Aberrant methylation of SPARC in human lung cancers.
British journal of cancer 2005;92(5):942-8.
2005: Hisayuki Shigematsu; Li Lin; Takao Takahashi; Masaharu Nomura; Makoto Suzuki; Ignacio I Wistuba; Kwun M Fong; Huei Lee; Shinichi Toyooka; Nobuyoshi Shimizu; Takehiko Fujisawa; Ziding Feng; Jack A Roth; Joachim Herz; John D Minna; Adi F Gazdar
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.
Journal of the National Cancer Institute 2005;97(5):339-46.
2005: Hisayuki Shigematsu; Takao Takahashi; Masaharu Nomura; Kuntal Majmudar; Makoto Suzuki; Huei Lee; Ignacio I Wistuba; Kwun M Fong; Shinichi Toyooka; Nobuyoshi Shimizu; Takehiko Fujisawa; John D Minna; Adi F Gazdar
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas.
Cancer research 2005;65(5):1642-6.
2005: Makoto Suzuki; Hisayuki Shigematsu; Takao Takahashi; Narayan Shivapurkar; Ubaradka G Sathyanarayana; Toshihiko Iizasa; Takehiko Fujisawa; Adi F Gazdar
Aberrant methylation of Reprimo in lung cancer.
Lung cancer (Amsterdam, Netherlands) 2005;47(3):309-14.
2005: Makoto Suzuki; Shinichi Toyooka; Narayan Shivapurkar; Hisayuki Shigematsu; Kuniharu Miyajima; Takao Takahashi; Victor Stastny; Andrea L Zern; Takehiko Fujisawa; Harvey I Pass; Michele Carbone; Adi F Gazdar
Aberrant methylation profile of human malignant mesotheliomas and its relationship to SV40 infection.
Oncogene 2005;24(7):1302-8.
2005: Hisayuki Shigematsu; Makoto Suzuki; Takao Takahashi; Kuniharu Miyajima; Shinichi Toyooka; Narayan Shivapurkar; Gail Tomlinson; Domenico Mastrangelo; Harvey I Pass; Elizabeth Brambilla; Ubaradka G Sathyanarayana; Bogdan Czerniak; Takehiko Fujisawa; Nobuyoshi Shimizu; Adi F Gazdar
Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies.
International journal of cancer. Journal international du cancer 2005;113(4):600-4.
2004: Hisayuki Shigematsu; Adi F Gazdar
Mutations of EGFR in lung cancers and their implications for targeted therapy.
Discovery medicine 2004;4(24):444-7.
2004: Takao Takahashi; Narayan Shivapurkar; Erick Riquelme; Hisayuki Shigematsu; Jyotsna Reddy; Makoto Suzuki; Kuniharu Miyajima; Xian Zhou; B Nebiyou Bekele; Adi F Gazdar; Ignacio I Wistuba
Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(18 Pt 1):6126-33.
2004: Adi F Gazdar; Kuniharu Miyajima; Jyotsna Reddy; Ubaradka G Sathyanarayana; Hisayuki Shigematsu; Makoto Suzuki; Takao Takahashi; Narayan Shivapurkar
Molecular targets for cancer therapy and prevention.
Chest 2004;125(5 Suppl):97S-101S.
2004: Takao Takahashi; Narayan Shivapurkar; Jyotsna Reddy; Hisayuki Shigematsu; Kuniharu Miyajima; Makoto Suzuki; Shinichi Toyooka; Sabine Zöchbauer-Müller; Johannes Drach; Gunjan Parikh; Yingye Zheng; Ziding Feng; Steven H Kroft; Charles F Timmons; Robert W McKenna; Adi F Gazdar
DNA methylation profiles of lymphoid and hematopoietic malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):2928-35.
2004: Narayan Shivapurkar; Shinichi Toyooka; Kiyomi O Toyooka; Jyotsna Reddy; Kuniharu Miyajima; Makoto Suzuki; Hisayuki Shigematsu; Takao Takahashi; Gunjan Parikh; Harvey I Pass; Preet M Chaudhary; Adi F Gazdar
Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types.
International journal of cancer. Journal international du cancer 2004;109(5):786-92.
2003: Ubaradka G Sathyanarayana; Asha Padar; Makoto Suzuki; Riichiroh Maruyama; Hisayuki Shigematsu; Jer-Tsong Hsieh; Eugene P Frenkel; Adi F Gazdar
Aberrant promoter methylation of laminin-5-encoding genes in prostate cancers and its relationship to clinicopathological features.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6395-400.
2003: Ubaradka G Sathyanarayana; Asha Padar; Chun Xian Huang; Makoto Suzuki; Hisayuki Shigematsu; B Nebiyou Bekele; Adi F Gazdar
Aberrant promoter methylation and silencing of laminin-5-encoding genes in breast carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6389-94.