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Barry Bloom

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Rosane M B Teles; Dennis Montoya; Stephen J Popper; Thomas H Rea; David A Relman; Euzenir N Sarno; Mirjam Schenk; Steffen Stenger; John S Adams; Barry R Bloom; Genhong Cheng; Rene Chun; Thomas G Graeber; Martin Hewison; Shankar S Iyer; Kindra Kelly-Scumpia; Evangelia Komisopoulou; Stephan R Krutzik; Delphine J Lee; Robert L Modlin
Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses.
Mario Fabri; Martin Hewison; Bruce W Hollis; Shankar S Iyer; Eun-Kyeong Jo; Stephan R Krutzik; Hye-Mi Lee; David M Lewinsohn; Philip T Liu; Dennis Montoya; Susan Realegeno; Mirjam Schenk; Dong-Min Shin; Peter Allan Sieling; Andreas Steinmeyer; Steffen Stenger; Rosane M B Teles; Jae-Min Yuk; Ulrich Zügel; John S Adams; Barry R Bloom; Heiko Bruns; Genhong Cheng; Robert L Modlin
Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages.
Samantha L Sampson; Barry R Bloom; Angela Carville; Elizabeth W Howerth; D Mitchell Magee; Keith G Mansfield; Teresa Quitugua; Mary K Hondalus
Extended safety and efficacy studies of a live attenuated double leucine and pantothenate auxotroph of Mycobacterium tuberculosis as a vaccine candidate.

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2013: Rosane M B Teles; Dennis Montoya; Stephen J Popper; Thomas H Rea; David A Relman; Euzenir N Sarno; Mirjam Schenk; Steffen Stenger; John S Adams; Barry R Bloom; Genhong Cheng; Rene Chun; Thomas G Graeber; Martin Hewison; Shankar S Iyer; Kindra Kelly-Scumpia; Evangelia Komisopoulou; Stephan R Krutzik; Delphine J Lee; Robert L Modlin
Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses.
Science (New York, N.Y.) 2013;339(6126):1448-53.
2011: Mario Fabri; Martin Hewison; Bruce W Hollis; Shankar S Iyer; Eun-Kyeong Jo; Stephan R Krutzik; Hye-Mi Lee; David M Lewinsohn; Philip T Liu; Dennis Montoya; Susan Realegeno; Mirjam Schenk; Dong-Min Shin; Peter Allan Sieling; Andreas Steinmeyer; Steffen Stenger; Rosane M B Teles; Jae-Min Yuk; Ulrich Zügel; John S Adams; Barry R Bloom; Heiko Bruns; Genhong Cheng; Robert L Modlin
Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages.
Science translational medicine 2011;3(104):104ra102.
2011: Samantha L Sampson; Barry R Bloom; Angela Carville; Elizabeth W Howerth; D Mitchell Magee; Keith G Mansfield; Teresa Quitugua; Mary K Hondalus
Extended safety and efficacy studies of a live attenuated double leucine and pantothenate auxotroph of Mycobacterium tuberculosis as a vaccine candidate.
Vaccine 2011;29(29-30):4839-47.
2011: Barry R Bloom
WHO needs change.
Nature 2011;473(7346):143-5.
2008: Karin B Michels; Barry R Bloom; Paul Riccardi; Bernard A Rosner; Walter C Willett
A study of the importance of education and cost incentives on individual food choices at the Harvard School of Public Health cafeteria.
Journal of the American College of Nutrition 2008;27(1):6-11.
2008: Jyothi RENGARAJAN; Elissa Murphy; Arnold Park; Cassandra L Krone; Erik C Hett; Barry R Bloom; Laurie H Glimcher; Eric J Rubin
Mycobacterium tuberculosis Rv2224c modulates innate immune responses.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(1):264-9.
2007: Sangeeta Khare; Mary K Hondalus; Jairo Nunes; Barry R Bloom; L Garry Adams
Mycobacterium bovis DeltaleuD auxotroph-induced protective immunity against tissue colonization, burden and distribution in cattle intranasally challenged with Mycobacterium bovis Ravenel S.
Vaccine 2007;25(10):1743-55.
2006: Belinda H Tan; Christoph Meinken; Max Bastian; Heiko Bruns; Annaliza J Legaspi; Maria Teresa Ochoa; Stephan R Krutzik; Barry R Bloom; Tomas Ganz; Robert L Modlin; Steffen Stenger
Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1864-71.
2006: Philip T Liu; Steffen Stenger; Huiying Li; Linda Wenzel; Belinda H Tan; Stephan R Krutzik; Maria Teresa Ochoa; Jürgen Schauber; Kent Wu; Christoph Meinken; Diane L Kamen; Manfred Wagner; Robert Bals; Andreas Steinmeyer; Ulrich Zügel; Richard L Gallo; David Eisenberg; Martin Hewison; Bruce W Hollis; John S Adams; Barry R Bloom; Robert L Modlin
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.
Science (New York, N.Y.) 2006;311(5768):1770-3.
2005: Sarah Fortune; A Jaeger; David A Sarracino; M R Chase; Christopher M Sassetti; emily glenn; Barry R Bloom; Eric J Rubin
Mutually dependent secretion of proteins required for mycobacterial virulence.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10676-81.
2005: Jyothi RENGARAJAN; Barry R Bloom; Eric J Rubin
Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(23):8327-32.
2005: Stephan R Krutzik; Belinda Tan; Huiying Li; Maria Teresa Ochoa; Philip T Liu; Sarah E Sharfstein; Thomas G Graeber; Peter Allan Sieling; Yong-Jun Liu; Thomas H Rea; Barry R Bloom; Robert L Modlin
TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells.
Nature medicine 2005;11(6):653-60.
2005: Hui Pan; Bo-Shiun Yan; Mauricio Rojas; Yuriy V Shebzukhov; Hongwei Zhou; Lester Kobzik; Darren E Higgins; Mark J Daly; Barry R Bloom; Igor Kramnik
Ipr1 gene mediates innate immunity to tuberculosis.
Nature 2005;434(7034):767-72.
2004: Jyothi RENGARAJAN; Christopher M Sassetti; Vera Naroditskaya; Alexander Sloutsky; Barry R Bloom; Eric J Rubin
The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria.
Molecular microbiology 2004;53(1):275-82.
2004: Sarah Fortune; Alejandra Solache; Alejandra Jaeger; Preston J Hill; John Belisle; Barry R Bloom; Eric J Rubin; Joel D Ernst
Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6272-80.
2004: Samantha L Sampson; Christopher Dascher; Vasan K Sambandamurthy; Robert G Russell; William R. Jacobs Jr.; Barry R Bloom; Mary K Hondalus
Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs.
Infection and immunity 2004;72(5):3031-7.
2003: Shruti Jain; Barry R Bloom; Mary K Hondalus
Deletion of vapA encoding Virulence Associated Protein A attenuates the intracellular actinomycete Rhodococcus equi.
Molecular microbiology 2003;50(1):115-28.
2003: Joshua R Bleharski; Huiying Li; Christoph Meinken; Thomas G Graeber; Maria Teresa Ochoa; Masahiro Yamamura; Anne E Burdick; Euzenir N Sarno; Manfred Wagner; Martin Röllinghoff; Thomas H Rea; Marco COLONna; Steffen Stenger; Barry R Bloom; David Eisenberg; Robert L Modlin
Use of genetic profiling in leprosy to discriminate clinical forms of the disease.
Science (New York, N.Y.) 2003;301(5639):1527-30.
2003: Adrie J C Steyn; Joan Joseph; Barry R Bloom
Interaction of the sensor module of Mycobacterium tuberculosis H37Rv KdpD with members of the Lpr family.
Molecular microbiology 2003;47(4):1075-89.
2002: J Reid Schwebach; Bing Chen; Aharona Glatman-Freedman; Arturo Casadevall; John D McKinney; John L Harb; Patrick J McGuire; W Emmett Barkley; Barry R Bloom; William R. Jacobs Jr.
Infection of mice with aerosolized Mycobacterium tuberculosis: use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility.
Applied and environmental microbiology 2002;68(9):4646-9.
2002: Barry R Bloom
Tuberculosis--the global view.
The New England journal of medicine 2002;346(19):1434-5.
2002: Adrie J C Steyn; Desmond M Collins; Mary K Hondalus; William R. Jacobs Jr.; R Pamela Kawakami; Barry R Bloom
Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3147-52.
2001: Robert L Modlin; Barry R Bloom
Immunology. Chip shots--will functional genomics get functional?
Science (New York, N.Y.) 2001;294(5543):799-801.
2001: S Thoma-Uszynski; Steffen Stenger; O Takeuchi; Maria Teresa Ochoa; Matthias Engele; Peter Allan Sieling; PF Barnes; M Rollinghoff; P L Bolcskei; Manfred Wagner; Shizuo Akira; Michael V Norgard; John Belisle; Paul J Godowski; Barry R Bloom; Robert L Modlin
Induction of direct antimicrobial activity through mammalian toll-like receptors.
Science (New York, N.Y.) 2001;291(5508):1544-7.
2000: W A Ernst; S Thoma-Uszynski; R Teitelbaum; C Ko; DA Hanson; Carol Clayberger; Alan Krensky; M Leippe; Barry R Bloom; Tomas Ganz; Robert L Modlin
Granulysin, a T cell product, kills bacteria by altering membrane permeability.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7102-8.
2000: S Cho; V Mehra; S Thoma-Uszynski; Steffen Stenger; NV Serbina; RJ Mazzaccaro; J L Flynn; P F Barnes; Scott Southwood; E Celis; Barry R Bloom; Robert L Modlin; A Sette
Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12210-5.
2000: Barry R Bloom
On the particularity of pathogens.
Nature 2000;406(6797):760-1.
2000: Igor Kramnik; William F Dietrich; P Demant; Barry R Bloom
Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8560-5.
2000: Mary K Hondalus; Svetoslav Bardarov; R Russell; John Chan; William R. Jacobs Jr.; Barry R Bloom
Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis.
Infection and immunity 2000;68(5):2888-98.
2000: Alexandra O Sousa; RJ Mazzaccaro; Robert G Russell; Francis K Lee; O C Turner; S Hong; Luc Van Kaer; Barry R Bloom
Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4204-8.
1999: R Teitelbaum; M Cammer; M L Maitland; Nancy E Freitag; John Condeelis; Barry R Bloom
Mycobacterial infection of macrophages results in membrane-permeable phagosomes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15190-5.
1999: Barry R Bloom
The future of public health.
Nature 1999;402(6761 Suppl):C63-4.
1999: Steffen Stenger; Jean-Pierre Rosat; Barry R Bloom; Alan Krensky; Robert L Modlin
Granulysin: a lethal weapon of cytolytic T cells.
Immunology today 1999;20(9):390-4.
1999: Barry R Bloom; J D McKinney
The death and resurrection of tuberculosis.
Nature medicine 1999;5(8):872-4.
1999: Hans D Brightbill; D H Libraty; Stephan R Krutzik; RB Yang; John Belisle; Joshua R Bleharski; M Maitland; Michael V Norgard; Scott Plevy; S T Smale; Patrick J Brennan; Barry R Bloom; Paul J Godowski; Robert L Modlin
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
Science (New York, N.Y.) 1999;285(5428):732-6.
1999: R Teitelbaum; William Schubert; L Gunther; Y Kress; Frank Macaluso; Jeffrey W Pollard; D N McMurray; Barry R Bloom
The M cell as a portal of entry to the lung for the bacterial pathogen Mycobacterium tuberculosis.
Immunity 1999;10(6):641-50.
1999: A M Caruso; NV Serbina; E Klein; K Triebold; Barry R Bloom; JoAnne L Flynn
Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(9):5407-16.
1998: R Teitelbaum; Aharona Glatman-Freedman; Bing Chen; John B Robbins; E Unanue; Arturo Casadevall; Barry R Bloom
A mAb recognizing a surface antigen of Mycobacterium tuberculosis enhances host survival.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15688-93.
1998: David Alland; Igor Kramnik; Torin R Weisbrod; L Otsubo; R Cerny; L P Miller; William R. Jacobs Jr.; Barry R Bloom
Identification of differentially expressed mRNA in prokaryotic organisms by customized amplification libraries (DECAL): the effect of isoniazid on gene expression in Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13227-32.
1998: Steffen Stenger; DA Hanson; R Teitelbaum; P Dewan; Kayvan R Niazi; C J Froelich; Tomas Ganz; S Thoma-Uszynski; A Melián; C Bogdan; Steven A Porcelli; Barry R Bloom; Alan Krensky; Robert L Modlin
An antimicrobial activity of cytolytic T cells mediated by granulysin.
Science (New York, N.Y.) 1998;282(5386):121-5.
1998: Marika Falcone; AJ Rajan; Barry R Bloom; Celia F Brosnan
A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4822-30.
1998: Barry R Bloom; R Widdus
Vaccine visions and their global impact.
Nature medicine 1998;4(5 Suppl):480-4.
1998: Barry R Bloom
The highest attainable standard: ethical issues in AIDS vaccines.
Science (New York, N.Y.) 1998;279(5348):186-8.
1998: RJ Mazzaccaro; Steffen Stenger; K L Rock; Steven A Porcelli; Michael B Brenner; Robert L Modlin; Barry R Bloom
Cytotoxic T lymphocytes in resistance to tuberculosis.
Advances in experimental medicine and biology 1998;452():85-101.
1997: Paul F Riska; William R. Jacobs Jr.; Barry R Bloom; John McKitrick; John Chan
Specific identification of Mycobacterium tuberculosis with the luciferase reporter mycobacteriophage: use of p-nitro-alpha-acetylamino-beta-hydroxy propiophenone.
Journal of clinical microbiology 1997;35(12):3225-31.
1997: Alexandra O Sousa; J I Salem; Francis K Lee; M C Verçosa; P Cruaud; Barry R Bloom; Philippe H Lagrange; H L David
An epidemic of tuberculosis with a high rate of tuberculin anergy among a population previously unexposed to tuberculosis, the Yanomami Indians of the Brazilian Amazon.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13227-32.
1997: Svetoslav Bardarov; Jordan Kriakov; C Carriere; S Yu; C Vaamonde; Ruth A McAdam; Barry R Bloom; Graham F Hatfull; William R. Jacobs Jr.
Conditionally replicating mycobacteriophages: a system for transposon delivery to Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10961-6.
1997: VE García; Peter Allan Sieling; J Gong; P F Barnes; K Uyemura; Y Tanaka; Barry R Bloom; Craig Morita; Robert L Modlin
Single-cell cytokine analysis of gamma delta T cell responses to nonpeptide mycobacterial antigens.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1328-35.
1997: J Kim; Alessandro Sette; S Rodda; Scott Southwood; Peter Allan Sieling; V Mehra; J D Ohmen; J Oliveros; Ettore Appella; Y Higashimoto; Thomas H Rea; Barry R Bloom; Robert L Modlin
Determinants of T cell reactivity to the Mycobacterium leprae GroES homologue.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):335-43.
1997: Steffen Stenger; RJ Mazzaccaro; K Uyemura; S Cho; PF Barnes; Jean-Pierre Rosat; A Sette; Michael B Brenner; Steven A Porcelli; Barry R Bloom; Robert L Modlin
Differential effects of cytolytic T cell subsets on intracellular infection.
Science (New York, N.Y.) 1997;276(5319):1684-7.
1997: Marika Falcone; Barry R Bloom
A T helper cell 2 (Th2) immune response against non-self antigens modifies the cytokine profile of autoimmune T cells and protects against experimental allergic encephalomyelitis.
The Journal of experimental medicine 1997;185(5):901-7.
1997: CD D'Souza; Andrea M Cooper; Anthony A Frank; RJ Mazzaccaro; Barry R Bloom; Ian M Orme
An anti-inflammatory role for gamma delta T lymphocytes in acquired immunity to Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1217-21.
1996: John Chan; Y Tian; Kathryn Tanaka; M S Tsang; K Yu; P Salgame; D Carroll; Yvonne Kress; R Teitelbaum; Barry R Bloom
Effects of protein calorie malnutrition on tuberculosis in mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14857-61.
1996: JoAnne L Flynn; Barry R Bloom
Role of T1 and T2 cytokines in the response to Mycobacterium tuberculosis.
Annals of the New York Academy of Sciences 1996;795():137-46.
1996: RJ Mazzaccaro; M Gedde; E R Jensen; H M van Santen; H L Ploegh; K L Rock; Barry R Bloom
Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11786-91.
1996: V Mehra; J H Gong; D Iyer; Y Lin; C T Boylen; Barry R Bloom; Peter F Barnes
Immune response to recombinant mycobacterial proteins in patients with tuberculosis infection and disease.
The Journal of infectious diseases 1996;174(2):431-4.
1996: Barry R Bloom
A perspective on AIDS vaccines.
Science (New York, N.Y.) 1996;272(5270):1888-90.
1996: Craig Morita; Y Tanaka; Barry R Bloom; Michael B Brenner
Direct presentation of non-peptide prenyl pyrophosphate antigens to human gamma delta T cells.
Research in immunology 1996;147(5):347-53.
1996: W J Philipp; S Poulet; Karin Eiglmeier; L Pascopella; V Balasubramanian; B Heym; S Bergh; Barry R Bloom; William R. Jacobs Jr.; Stewart T Cole
An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):3132-7.
1996: I Guleria; R Teitelbaum; R A McAdam; Ganjam V Kalpana; William R. Jacobs Jr.; Barry R Bloom
Auxotrophic vaccines for tuberculosis.
Nature medicine 1996;2(3):334-7.
1996: H E Takiff; M Cimino; M C Musso; Torin R Weisbrod; R Martinez; M B Delgado; L Salazar; Barry R Bloom; William R. Jacobs Jr.
Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):362-6.
1996: V Balasubramanian; M S Pavelka; Svetoslav Bardarov; J Martin; Torin R Weisbrod; R A McAdam; Barry R Bloom; William R. Jacobs Jr.
Allelic exchange in Mycobacterium tuberculosis with long linear recombination substrates.
Journal of bacteriology 1996;178(1):273-9.
1995: Craig Morita; E M Beckman; Jack F Bukowski; Y Tanaka; Hamid Band; Barry R Bloom; D E Golan; Michael B Brenner
Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells.
Immunity 1995;3(4):495-507.
1995: JoAnne L Flynn; M M Goldstein; K J Triebold; Joe Sypek; S Wolf; Barry R Bloom
IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(5):2515-24.
1995: Desmond M Collins; R P Kawakami; Geoffrey W de Lisle; L Pascopella; Barry R Bloom; William R. Jacobs Jr.
Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):8036-40.
1995: Peter Allan Sieling; D Chatterjee; Steven A Porcelli; T I Prigozy; RJ Mazzaccaro; T Soriano; Barry R Bloom; Michael B Brenner; Mitchell Kronenberg; P J Brennan
CD1-restricted T cell recognition of microbial lipoglycan antigens.
Science (New York, N.Y.) 1995;269(5221):227-30.
1995: JoAnne L Flynn; M M Goldstein; John Chan; K J Triebold; K Pfeffer; Charles J Lowenstein; R Schreiber; T W Mak; Barry R Bloom
Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice.
Immunity 1995;2(6):561-72.
1995: Barry R Bloom
A perspective on issues relating to future vaccines.
Annals of the New York Academy of Sciences 1995;754():388-95.
1995: Y Tanaka; Craig Morita; Y Tanaka; Edward Nieves; M B Brenner; Barry R Bloom
Natural and synthetic non-peptide antigens recognized by human gamma delta T cells.
Nature 1995;375(6527):155-8.
1995: Jeffrey D Cirillo; C Kendall Stover; Barry R Bloom; William R. Jacobs Jr.; Raúl G Barletta
Bacterial vaccine vectors and bacillus Calmette-Guérin.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1995;20(4):1001-9.
1995: R A McAdam; Torin R Weisbrod; J Martin; J D Scuderi; AMANDA BROWN; Jeffrey D Cirillo; Barry R Bloom; William R. Jacobs Jr.
In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis.
Infection and immunity 1995;63(3):1004-12.
1995: Arye Rubinstein; Harris Goldstein; M Pettoello-Mantovani; Y Mizrachi; Barry R Bloom; E Furer; B Althaus; John U Que; T Hasler; Stanley J Cryz
Safety and immunogenicity of a V3 loop synthetic peptide conjugated to purified protein derivative in HIV-seronegative volunteers.
AIDS (London, England) 1995;9(3):243-51.
1995: Jack F Bukowski; Craig Morita; Y Tanaka; Barry R Bloom; Michael B Brenner; Hamid Band
V gamma 2V delta 2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(3):998-1006.
1994: Barry R Bloom; J Flynn; K McDonough; Y Kress; John Chan
Experimental approaches to mechanisms of protection and pathogenesis in M. tuberculosis infection.
Immunobiology 1994;191(4-5):526-36.
1994: Barry R Bloom
The United States needs a national vaccine authority.
Science (New York, N.Y.) 1994;265(5177):1378-80.
1994: Y Tanaka; S Sano; Edward Nieves; G De Libero; D Rosa; Robert L Modlin; M B Brenner; Barry R Bloom; Craig Morita
Nonpeptide ligands for human gamma delta T cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):8175-9.
1994: Jeffrey D Cirillo; Torin R Weisbrod; A Banerjee; Barry R Bloom; William R. Jacobs Jr.
Genetic determination of the meso-diaminopimelate biosynthetic pathway of mycobacteria.
Journal of bacteriology 1994;176(14):4424-9.
1994: David Alland; Gary Kalkut; Andrew R Moss; R A McAdam; Judith Hahn; W Bosworth; Ernest Drucker; Barry R Bloom
Transmission of tuberculosis in New York City. An analysis by DNA fingerprinting and conventional epidemiologic methods.
The New England journal of medicine 1994;330(24):1710-6.
1994: L Pascopella; F M Collins; J M Martin; M H Lee; G F Hatfull; C Kendall Stover; Barry R Bloom; William R. Jacobs Jr.
Use of in vivo complementation in Mycobacterium tuberculosis to identify a genomic fragment associated with virulence.
Infection and immunity 1994;62(4):1313-9.
1994: J D Ohmen; Peter F Barnes; C L Grisso; Barry R Bloom; Robert L Modlin
Evidence for a superantigen in human tuberculosis.
Immunity 1994;1(1):35-43.
1994: Jeffrey D Cirillo; Torin R Weisbrod; L Pascopella; Barry R Bloom; William R. Jacobs Jr.
Isolation and characterization of the aspartokinase and aspartate semialdehyde dehydrogenase operon from mycobacteria.
Molecular microbiology 1994;11(4):629-39.
1993: Nancy Connell; E Medina-Acosta; W Robert McMaster; Barry R Bloom; D G Russell
Effective immunization against cutaneous leishmaniasis with recombinant bacille Calmette-Guérin expressing the Leishmania surface proteinase gp63.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11473-7.
1993: JoAnne L Flynn; John Chan; K J Triebold; Dyana Dalton; Timothy A Stewart; Barry R Bloom
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
The Journal of experimental medicine 1993;178(6):2249-54.
1993: Robert L Modlin; Barry R Bloom
Immune regulation: learning from leprosy.
Hospital practice (Office ed.) 1993;28(11):71-4, 77-80, 83-4.
1993: E M Schwarz; P Salgame; Barry R Bloom
Molecular regulation of human interleukin 2 and T-cell function by interleukin 4.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7734-8.
1993: L Pascopella; F M Collins; J M Martin; William R. Jacobs Jr.; Barry R Bloom
Identification of a genomic fragment of Mycobacterium tuberculosis responsible for in vivo growth advantage.
Infectious agents and disease 1993;2(4):282-4.
1993: JoAnne L Flynn; M M Goldstein; K J Triebold; Barry R Bloom
Major histocompatibility complex class I-restricted T cells are necessary for protection against M. tuberculosis in mice.
Infectious agents and disease 1993;2(4):259-62.
1993: K A McDonough; Y Kress; Barry R Bloom
The interaction of Mycobacterium tuberculosis with macrophages: a study of phagolysosome fusion.
Infectious agents and disease 1993;2(4):232-5.
1993: K A McDonough; Y Kress; Barry R Bloom
Pathogenesis of tuberculosis: interaction of Mycobacterium tuberculosis with macrophages.
Infection and immunity 1993;61(7):2763-73.
1993: Peter Allan Sieling; J S Abrams; M Yamamura; P Salgame; Barry R Bloom; Thomas H Rea; Robert L Modlin
Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(12):5501-10.
1993: William R. Jacobs Jr.; R G Barletta; R Udani; John Chan; Gary Kalkut; Gabriel Sosne; T Kieser; G J Sarkis; Graham F Hatfull; Barry R Bloom
Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages.
Science (New York, N.Y.) 1993;260(5109):819-22.
1992: JoAnne L Flynn; M M Goldstein; K J Triebold; B Koller; Barry R Bloom
Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):12013-7.
1992: Barry R Bloom; C J Murray
Tuberculosis: commentary on a reemergent killer.
Science (New York, N.Y.) 1992;257(5073):1055-64.
1992: M Yamamura; X H Wang; J D Ohmen; K Uyemura; Thomas H Rea; Barry R Bloom; Robert L Modlin
Cytokine patterns of immunologically mediated tissue damage.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(4):1470-5.
1992: John Chan; Y Xing; Richard Magliozzo; Barry R Bloom
Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages.
The Journal of experimental medicine 1992;175(4):1111-22.
1992: Barry R Bloom; P Salgame; Betty Diamond
Revisiting and revising suppressor T cells.
Immunology today 1992;13(4):131-6.
1992: Peter F Barnes; V Mehra; B Rivoire; S J Fong; Patrick J Brennan; M S Voegtline; P Minden; R A Houghten; Barry R Bloom; Robert L Modlin
Immunoreactivity of a 10-kDa antigen of Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(6):1835-40.
1992: V Mehra; Barry R Bloom; A C Bajardi; C L Grisso; Peter Allan Sieling; DAvid Alland; Jacinto Convit; X D Fan; S W Hunter; Patrick J Brennan
A major T cell antigen of Mycobacterium leprae is a 10-kD heat-shock cognate protein.
The Journal of experimental medicine 1992;175(1):275-84.
1992: Raúl G Barletta; D D Kim; S B Snapper; Barry R Bloom; William R. Jacobs Jr.
Identification of expression signals of the mycobacteriophages Bxb1, L1 and TM4 using the Escherichia-Mycobacterium shuttle plasmids pYUB75 and pYUB76 designed to create translational fusions to the lacZ gene.
Journal of general microbiology 1992;138(1):23-30.
1992: Barry R Bloom; Robert L Modlin; P Salgame
Stigma variations: observations on suppressor T cells and leprosy.
Annual review of immunology 1992;10():453-88.
1992: P Salgame; M Yamamura; Barry R Bloom; Robert L Modlin
Evidence for functional subsets of CD4+ and CD8+ T cells in human disease: lymphokine patterns in leprosy.
Chemical immunology 1992;54():44-59.
1991: Jeffrey D Cirillo; Raúl G Barletta; Barry R Bloom; William R. Jacobs Jr.
A novel transposon trap for mycobacteria: isolation and characterization of IS1096.
Journal of bacteriology 1991;173(24):7772-80.
1991: L Sullivan; S Sano; C Pirmez; P Salgame; Christoph Mueller; Florence M Hofman; K Uyemura; Thomas H Rea; Barry R Bloom; Robert L Modlin
Expression of adhesion molecules in leprosy lesions.
Infection and immunity 1991;59(11):4154-60.
1991: M Yamamura; K Uyemura; R J Deans; K Weinberg; Thomas H Rea; Barry R Bloom; Robert L Modlin
Defining protective responses to pathogens: cytokine profiles in leprosy lesions.
Science (New York, N.Y.) 1991;254(5029):277-9.
1991: P Salgame; J S Abrams; C Clayberger; Harris Goldstein; Jacinto Convit; Robert L Modlin; Barry R Bloom
Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones.
Science (New York, N.Y.) 1991;254(5029):279-82.
1991: Ganjam V Kalpana; Barry R Bloom; William R. Jacobs Jr.
Insertional mutagenesis and illegitimate recombination in mycobacteria.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5433-7.
1991: John Chan; X D Fan; S W Hunter; Patrick J Brennan; Barry R Bloom
Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages.
Infection and immunity 1991;59(5):1755-61.
1991: P Salgame; Jacinto Convit; Barry R Bloom
Immunological suppression by human CD8+ T cells is receptor dependent and HLA-DQ restricted.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(6):2598-602.
1991: William R. Jacobs Jr.; Ganjam V Kalpana; Jeffrey D Cirillo; L Pascopella; S B Snapper; R A Udani; W Jones; Raúl G Barletta; Barry R Bloom
Genetic systems for mycobacteria.
Methods in enzymology 1991;204():537-55.
1990: Raúl G Barletta; B Snapper; Jeffrey D Cirillo; Nancy Connell; D D Kim; William R. Jacobs Jr.; Barry R Bloom
Recombinant BCG as a candidate oral vaccine vector.
Research in microbiology 1990;141(7-8):931-9.
1990: S W Hunter; B Rivoire; V Mehra; Barry R Bloom; Patrick J Brennan
The major native proteins of the leprosy bacillus.
The Journal of biological chemistry 1990;265(24):14065-8.
1990: Barry R Bloom
An ordinary mortal's guide to the molecular biology of mycobacteria.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 1990;58(2):365-75.
1990: William R. Jacobs Jr.; S B Snapper; L Lugosi; Barry R Bloom
Development of BCG as a recombinant vaccine vehicle.
Current topics in microbiology and immunology 1990;155():153-60.
1989: Barry R Bloom
Vaccines for the Third World.
Nature 1989;342(6246):115-20.
1989: L Lugosi; William R. Jacobs Jr.; Barry R Bloom
Genetic transformation of BCG.
Tubercle 1989;70(3):159-70.
1989: Robert L Modlin; C Pirmez; Florence M Hofman; V Torigian; K Uyemura; Thomas H Rea; Barry R Bloom; M B Brenner
Lymphocytes bearing antigen-specific gamma delta T-cell receptors accumulate in human infectious disease lesions.
Nature 1989;339(6225):544-8.
1989: C M Grosskinsky; William R. Jacobs Jr.; J E Clark-Curtiss; Barry R Bloom
Genetic relationships among Mycobacterium leprae, Mycobacterium tuberculosis, and candidate leprosy vaccine strains determined by DNA hybridization: identification of an M. leprae-specific repetitive sequence.
Infection and immunity 1989;57(5):1535-41.
1989: C L Cooper; Christoph Mueller; T A Sinchaisri; C Pirmez; John Chan; G Kaplan; S M Young; I L Weissman; Barry R Bloom; Thomas H Rea
Analysis of naturally occurring delayed-type hypersensitivity reactions in leprosy by in situ hybridization.
The Journal of experimental medicine 1989;169(5):1565-81.
1989: X D Fan; G R Stark; Barry R Bloom
Molecular cloning of a gene selectively induced by gamma interferon from human macrophage cell line U937.
Molecular and cellular biology 1989;9(5):1922-8.
1989: V Mehra; Barry R Bloom; V K Torigian; D Mandich; M Reichel; S M Young; P Salgame; Jacinto Convit; S W Hunter; Michael McNeil
Characterization of Mycobacterium leprae cell wall-associated proteins with the use of T lymphocyte clones.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(8):2873-8.
1989: S W Hunter; Michael McNeil; Robert L Modlin; V Mehra; Barry R Bloom; Patrick J Brennan
Isolation and characterization of the highly immunogenic cell wall-associated protein of Mycobacterium leprae.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(8):2864-72.
1989: William R. Jacobs Jr.; S B Snapper; M Tuckman; Barry R Bloom
Mycobacteriophage vector systems.
Reviews of infectious diseases 1989;11 Suppl 2():S404-10.
1989: Barry R Bloom
New approaches to vaccine development.
Reviews of infectious diseases 1989;11 Suppl 2():S460-6.
1989: Barry R Bloom; P Salgame; V Mehra; H Kato; Robert L Modlin; T Rea; P Brennan; Jacinto Convit; L Lugozi; S Snapper
Vaccine development. On relating immunology to the Third World: some studies on leprosy.
Immunology. Supplement 1989;2():87-9; discussion 91-2.
1989: P Salgame; Robert L Modlin; Barry R Bloom
On the mechanism of human T cell suppression.
International immunology 1989;1(2):121-9.
1989: Barry R Bloom; William R. Jacobs Jr.
New strategies for leprosy and tuberculosis and for development of bacillus Calmette-Guérin into a multivaccine vehicle.
Annals of the New York Academy of Sciences 1989;569():155-73.
1989: L Lugosi; William R. Jacobs Jr.; Barry R Bloom
Transformation of BCG with plasmid DNA.
Acta leprologica 1989;7 Suppl 1():256-7.
1989: William R. Jacobs Jr.; S B Snapper; L Lugosi; A Jekkel; R E Melton; T Kieser; Barry R Bloom
Development of genetic systems for the mycobacteria.
Acta leprologica 1989;7 Suppl 1():203-7.
1988: S B Snapper; L Lugosi; A Jekkel; R E Melton; T Kieser; Barry R Bloom; William R. Jacobs Jr.
Lysogeny and transformation in mycobacteria: stable expression of foreign genes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6987-91.
1988: X D Fan; M Goldberg; Barry R Bloom
Interferon-gamma-induced transcriptional activation is mediated by protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(14):5122-5.
1988: J Melancon-Kaplan; S W Hunter; Michael McNeil; C Stewart; Robert L Modlin; Thomas H Rea; Jacinto Convit; P Salgame; V Mehra; Barry R Bloom
Immunological significance of Mycobacterium leprae cell walls.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(6):1917-21.
1988: Robert L Modlin; J Melancon-Kaplan; S M Young; C Pirmez; H Kino; Jacinto Convit; Thomas H Rea; Barry R Bloom
Learning from lesions: patterns of tissue inflammation in leprosy.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(4):1213-7.
1988: Barry R Bloom; V Mehra; J Melancon-Kaplan; M Castes; Jacinto Convit; Patrick J Brennan; Thomas H Rea; Robert L Modlin
Mechanisms of immunological unresponsiveness in the spectra of leprosy and leishmaniasis.
Advances in experimental medicine and biology 1988;239():263-78.
1987: Robert L Modlin; M B Brenner; M S Krangel; A D Duby; Barry R Bloom
T-cell receptors of human suppressor cells.
Nature 1987;329(6139):541-5.
1986: Robert L Modlin; G M Gersuk; E E Nelson; Paul K Pattengale; J R Gunter; L Chen; C L Cooper; Barry R Bloom; Thomas H Rea
T-lymphocyte clones from leprosy skin lesions.
Leprosy review 1986;57 Suppl 2():143-7.
1986: Robert L Modlin; V Mehra; L Wong; Yoshiaki Fujimiya; W C Chang; D A Horwitz; Barry R Bloom; Thomas H Rea; Paul K Pattengale
Suppressor T lymphocytes from lepromatous leprosy skin lesions.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(9):2831-4.
1986: Robert L Modlin; H Kato; V Mehra; E E Nelson; X D Fan; Thomas H Rea; Paul K Pattengale; Barry R Bloom
Genetically restricted suppressor T-cell clones derived from lepromatous leprosy lesions.
Nature 1986;322(6078):459-61.
1985: Robert L Modlin; F J Tapia; Barry R Bloom; M E Gallinoto; M Castes; A J Rondon; Thomas H Rea; Jacinto Convit
In situ characterization of the cellular immune response in American cutaneous leishmaniasis.
Clinical and experimental immunology 1985;60(2):241-8.
1984: V Mehra; Patrick J Brennan; Elsa Rada; Jacinto Convit; Barry R Bloom
Lymphocyte suppression in leprosy induced by unique M. leprae glycolipid.
Nature 1984;308(5955):194-6.
1982: V Mehra; Jacinto Convit; Arye Rubinstein; Barry R Bloom
Activated suppressor T cells in leprosy.
Journal of immunology (Baltimore, Md. : 1950) 1982;129(5):1946-51.