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Shin-Ru Shih

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Shih-Cheng Chang; C-J Chen; Cheng-Hsun Chiu; Y-C Hsieh; K-Y Huang; Yhu-Chering Huang; C-Y Kuo; W-C Li; Shin-Ru Shih; Tzou-Yien Lin
Efficacy of alcohols and alcohol-based hand disinfectants against human enterovirus 71.
Li-Lien Chen; Jim-Tong Horng; Yu-An Kung; Jing-Yi Lin; Kuo-Feng Weng; Shin-Ru Shih
Enterovirus 71 infection cleaves a negative regulator for viral internal ribosomal entry site-driven translation.
Rei-Lin Kuo; Sue-Jane Lin; Li-Ting Kao; Robert Yung-Liang Wang; Shin-Ru Shih
MDA5 Plays a Crucial Role in Enterovirus 71 RNA-Mediated IRF3 Activation.

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2013: Shih-Cheng Chang; C-J Chen; Cheng-Hsun Chiu; Y-C Hsieh; K-Y Huang; Yhu-Chering Huang; C-Y Kuo; W-C Li; Shin-Ru Shih; Tzou-Yien Lin
Efficacy of alcohols and alcohol-based hand disinfectants against human enterovirus 71.
The Journal of hospital infection 2013;83(4):288-93.
2013: Li-Lien Chen; Jim-Tong Horng; Yu-An Kung; Jing-Yi Lin; Kuo-Feng Weng; Shin-Ru Shih
Enterovirus 71 infection cleaves a negative regulator for viral internal ribosomal entry site-driven translation.
Journal of virology 2013;87(7):3828-38.
2013: Rei-Lin Kuo; Sue-Jane Lin; Li-Ting Kao; Robert Yung-Liang Wang; Shin-Ru Shih
MDA5 Plays a Crucial Role in Enterovirus 71 RNA-Mediated IRF3 Activation.
PloS one 2013;8(5):e63431.
2013: Rei-Lin Kuo; Shin-Ru Shih
Strategies to develop antivirals against enterovirus 71.
Virology journal 2013;10():28.
2012: Yu-Nong Gong; Guang-Wu Chen; Shin-Ru Shih
Characterization of subtypes of the influenza A hemagglutinin (HA) gene using profile hidden Markov models.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2012;45(6):404-10.
2012: Kuan-Ru Chen; Lin-Fang Chen; En-Wei Hsing; Ching-Yu Huang; Huan-Yao Lei; Chun-Yang Lin; Wan-Ying Lin; Yin-Chiu Lo; Ai-Li Shiau; Shin-Ru Shih; Tse-Hua Tan; Chia-Yu Yang; Chun-Hung Chang; Pin Ling
TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity.
The Journal of biological chemistry 2012;287(38):32216-21.
2012: Jiann-Yih Yeh; Teng-Kuang Yeh; Yu-Sheng Chao; Mohane Coumar; Ming-Yu Fang; Jim-Tong Horng; John T A Hsu; Yu-Lin Huang; Hui-Chen Hung; Shengkai Ko; Fu-Ming Kuo; Yen-Chun Lee; Ta-Jen Lin; Hui-Yi Shiao; Shin-Ru Shih; Hsing-Pang Hsieh
Anti-influenza drug discovery: identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization.
ChemMedChem 2012;7(9):1546-50.
2012: Shih-Cheng Chang; Guang-Wu Chen; Cheng-Hsun Chiu; Chung-Guei Huang; Yhu-Chering Huang; Chen-Yen Kuo; Wen-Chen Li; Shin-Ru Shih; Kun-Nan Tsai; Kuo-Chien Tsao; Tzou-Yien Lin
Genetic characterization of enterovirus 71 isolated from patients with severe disease by comparative analysis of complete genomes.
Journal of medical virology 2012;84(6):931-9.
2012: Hsing-I Huang; Kuo-Feng Weng; Shin-Ru Shih
Viral and host factors that contribute to pathogenicity of enterovirus 71.
Future microbiology 2012;7(4):467-79.
2012: Yi-Jen Chen; Shih-Cheng Chang; Tzou-Yien Lin; Shin-Ru Shih; Kuo-Chien Tsao; Shu-Li Yang; Yhu-Chering Huang
Comparative genomic analysis of coxsackievirus A6 strains of different clinical disease entities.
PloS one 2012;7(12):e52432.
2012: Guang-Wu Chen; Yu-Nong Gong; Chung-Guei Huang; Yhu-Chering Huang; Tzou-Yien Lin; Yi-Chun Liu; Kuo-Chien Tsao; Hsiao-Han Wu; Shu-Li Yang; Shih-Cheng Chang; Shin-Ru Shih
Amino acids transitioning of 2009 H1N1pdm in Taiwan from 2009 to 2011.
PloS one 2012;7(9):e45946.
2011: Shin-Ru Shih; Victor Stollar; Mei-Ling Li
Host factors in enterovirus 71 replication.
Journal of virology 2011;85(19):9658-66.
2011: Erh-Fang Hsieh; Chih-Heng Huang; Sue-Jane Lin; Chee-Keng Mok; David M Ojcius; Chi-Jene Chen; Guang-Wu Chen; Tzu-Chun Chen; Yeau-Ching Wang; Shin-Ru Shih
Altered pathogenicity for seasonal influenza virus by single reassortment of the RNP genes derived from the 2009 pandemic influenza virus.
The Journal of infectious diseases 2011;204(6):864-72.
2011: Shu-Chuan Chen; Yi-Chun Chen; Shin-Ru Shih; Yi-Wei Wang; Kuo-Feng Weng; Luan-Yin Chang; Hsiu-Ming Shih
Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis.
The Journal of biological chemistry 2011;286(36):31373-84.
2011: Hui-Chen Hung; Hsiang-Ching Wang; Shin-Ru Shih; I-Fang Teng; Ching-Ping Tseng; John T A Hsu
Synergistic inhibition of enterovirus 71 replication by interferon and rupintrivir.
The Journal of infectious diseases 2011;203(12):1784-90.
2011: Tzu-Chun Chen; Shin-Ru Shih
Drug discovery in enteroviral infections.
Infectious disorders drug targets 2011;11(3):337-45.
2011: Nadia Naffakh; Shin-Ru Shih
Confronting influenza virus: a common but ever-changing pathogen.
Microbes and infection / Institut Pasteur 2011;13(5):468-9.
2011: Iou-Jiun Kang; Li-Wen Wang; Tsu-An Hsu; Andrew Yueh; Chung-Chi Lee; Yen-Chun Lee; Ching-Yin Lee; Yu-Sheng Chao; Shin-Ru Shih; Jyh-Haur Chern
Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(7):1948-52.
2011: Daniel Tsung-Ning Huang; Pei-Lan Shao; Kuo-Chin Huang; Chun-Yi Lu; Jen-Ren Wang; Shin-Ru Shih; Hsin Chi; Mei-Ru Lai; Chin-Yun Lee; Luan-Yin Chang; Li-Min Huang
Serologic status for pandemic (H1N1) 2009 virus, Taiwan.
Emerging infectious diseases 2011;17(1):76-8.
2010: Shih-Cheng Chang; Chung-Ming Chang; Yhu-Chering Huang; Cheng-Hsun Chiu; Shin-Ru Shih; Tzou-Yen Lin
Preexisting antibodies against pandemic 2009 influenza A (H1N1) virus in Taiwan.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010;51(12):1465-7.
2010: Chi-Jene Chen; Guang-Wu Chen; Ching-Ho Wang; Chih-Heng Huang; Yeau-Ching Wang; Shin-Ru Shih
Differential localization and function of PB1-F2 derived from different strains of influenza A virus.
Journal of virology 2010;84(19):10051-62.
2010: Chiuan-Chian Chiou; Tai-Long Chen; Kuo-Chien Tsao; Shin-Ru Shih; Chung-Guei Huang; Ya-Ling Huang; Chung-Ming Chang
Detection of pandemic (H1N1) 2009 influenza virus by allele discrimination.
Clinica chimica acta; international journal of clinical chemistry 2010;411(15-16):1080-3.
2010: Wei-Ju Su; Pei-Lan Shao; Ming-Tsan Liu; Ding-Ping Liu; Kuo-Chin Huang; Luan-Yin Chang; Chun-Yi Lu; Jen-Ren Wang; Shin-Ru Shih; Daniel Tsung-Ning Huang; Hsin Chi; Li-Min Huang
Low seroprotection against preseasonal influenza local strains in children might predict the upcoming epidemic influenza strains.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010;51(2):171-6.
2010: Kuo-Feng Weng; Li-Lien Chen; Peng-Nien Huang; Shin-Ru Shih
Neural pathogenesis of enterovirus 71 infection.
Microbes and infection / Institut Pasteur 2010;12(7):505-10.
2010: Kuo-Chien Tsao; Chung-Guei Huang; Ya-Ling Huang; Feng-Chu Chen; Peng-Nien Huang; Yuh-Chering Huang; Tzou-Yen Lin; Shin-Ru Shih; Shih-Cheng Chang
Epidemiologic features and virus isolation of enteroviruses in Northern Taiwan during 2000-2008.
Journal of virological methods 2010;165(2):330-2.
2010: Hui-Chen Hung; Tzu-Chun Chen; Ming-Yu Fang; Kuei-Jung Yen; Shin-Ru Shih; John T A Hsu; Ching-Ping Tseng
Inhibition of enterovirus 71 replication and the viral 3D polymerase by aurintricarboxylic acid.
The Journal of antimicrobial chemotherapy 2010;65(4):676-83.
2010: Chung-Guei Huang; Kuo-Chien Tsao; Tzou-Yien Lin; Yhu-Chering Huang; Li-Ang Lee; Tzu-Hou Chen; Ya-Ling Huang; Shin-Ru Shih
Estimates of individuals exposed to human metapneumovirus in a community-based Taiwanese population in 1999.
Archives of virology 2010;155(3):343-50.
2010: Jiann-Yih Yeh; Mohane Coumar; Jim-Tong Horng; Hui-Yi Shiao; Fu-Ming Kuo; Hui-Ling Lee; In-Chun Chen; Chun-Wei Chang; Wen-Fang Tang; Sung-Nien Tseng; Chi-Jene Chen; Shin-Ru Shih; John T A Hsu; Chun-Chen Liao; Yu-Sheng Chao; Hsing-Pang Hsieh
Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives.
Journal of medicinal chemistry 2010;53(4):1519-33.
2010: Hurng-Yi Wang; Kao-Chien Tsao; Chia-Hung Hsieh; Li-Min Huang; Tzou-Yien Lin; Guang-Wu Chen; Shin-Ru Shih; Luan-Yin Chang
Inferring nonneutral evolution from contrasting patterns of polymorphisms and divergences in different protein coding regions of enterovirus 71 circulating in Taiwan during 1998-2003.
BMC evolutionary biology 2010;10():294.
2010: Shin-Ru Shih; Tzu-Yun Chu; Gadarla Randheer Reddy; Sung-Nain Tseng; Hsiun-Ling Chen; Wen-Fang Tang; Ming-sian Wu; Jiann-Yih Yeh; Yu-Sheng Chao; John Ta Hsu; Hsing-Pang Hsieh; Jim-Tong Horng
Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity.
Journal of biomedical science 2010;17():13.
2010: Shin-Ru Shih; Jim-Tong Horng; Leo L M Poon; Tzu-Chun Chen; Jiann-Yih Yeh; Hsing-Pang Hsieh; Sung-Nain Tseng; Chiayn Chiang; Wan-Ling Li; Yu-Sheng Chao; John T A Hsu
BPR2-D2 targeting viral ribonucleoprotein complex-associated function inhibits oseltamivir-resistant influenza viruses.
The Journal of antimicrobial chemotherapy 2010;65(1):63-71.
2009: Guang-Wu Chen; Shin-Ru Shih
Genomic signatures of influenza A pandemic (H1N1) 2009 virus.
Emerging infectious diseases 2009;15(12):1897-1903.
2009: Kuo-Feng Weng; Mei-Ling Li; Chuan-Tien Hung; Shin-Ru Shih
Enterovirus 71 3C protease cleaves a novel target CstF-64 and inhibits cellular polyadenylation.
PLoS pathogens 2009;5(9):e1000593.
2009: Luan-Yin Chang; Shin-Ru Shih; Pei-Lan Shao; Daniel Tsung-Ning Huang; Li-Min Huang
Novel swine-origin influenza virus A (H1N1): the first pandemic of the 21st century.
Journal of the Formosan Medical Association = Taiwan yi zhi 2009;108(7):526-32.
2009: Tzu-Chun Chen; Hwan-You Chang; Pei-Fen Lin; Jyh-Haur Chern; John Tsu-An Hsu; Chu-Yi Chang; Shin-Ru Shih
Novel antiviral agent DTriP-22 targets RNA-dependent RNA polymerase of enterovirus 71.
Antimicrobial agents and chemotherapy 2009;53(7):2740-7.
2009: Jing-Yi Lin; Shin-Ru Shih; Manjing Pan; Carol Li; Chia-Fang Lue; Victor Stollar; Mei-Ling Li
hnRNP A1 interacts with the 5' untranslated regions of enterovirus 71 and Sindbis virus RNA and is required for viral replication.
Journal of virology 2009;83(12):6106-14.
2009: Kun-Nan Tsai; Shu-Hung Lin; Shin-Ru Shih; Jhih-Siang Lai; Chung-Ming Chen
Genomic splice site prediction algorithm based on nucleotide sequence pattern for RNA viruses.
Computational biology and chemistry 2009;33(2):171-5.
2009: Cheng-Chung Lee; Chih-Jung Kuo; Tzu-Ping Ko; Min-Feng Hsu; Yao-Chen Tsui; Shih-Cheng Chang; Syaulan Yang; Shu-Jen Chen; Hua-Chien Chen; Ming-Chu Hsu; Shin-Ru Shih; Po-Huang Liang; Andrew H-J Wang
Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds.
The Journal of biological chemistry 2009;284(12):7646-55.
2009: Hui-Chen Hung; Ching-Ping Tseng; Jinn-Moon Yang; Yi-Wei Ju; Sung-Nain Tseng; Yen-Fu Chen; Yu-Sheng Chao; Hsing-Pang Hsieh; Shin-Ru Shih; John T-A Hsu
Aurintricarboxylic acid inhibits influenza virus neuraminidase.
Antiviral research 2009;81(2):123-31.
2009: Jing-Yi Lin; Tzu-Chun Chen; Kuo-Feng Weng; Shih-Cheng Chang; Li-Lien Chen; Shin-Ru Shih
Viral and host proteins involved in picornavirus life cycle.
Journal of biomedical science 2009;16():103.
2009: Jing-Yi Lin; Mei-Ling Li; Shin-Ru Shih
Far upstream element binding protein 2 interacts with enterovirus 71 internal ribosomal entry site and negatively regulates viral translation.
Nucleic acids research 2009;37(1):47-59.
2008: Luan-Yin Chang; I-Shou Chang; Wei-Jen Chen; Yhu-Cherng Huang; Guang-Wu Chen; Shin-Ru Shih; Jyh-Lyh Juang; Hsiu-Ming Shih; Chao A Hsiung; Tzou-Yien Lin; Li-Min Huang
HLA-A33 is associated with susceptibility to enterovirus 71 infection.
Pediatrics 2008;122(6):1271-6.
2008: Tzu-Chun Chen; Kuo-Feng Weng; Shih-Cheng Chang; Jing-Yi Lin; Peng-Nien Huang; Shin-Ru Shih
Development of antiviral agents for enteroviruses.
The Journal of antimicrobial chemotherapy 2008;62(6):1169-73.
2008: Ying-ju Chen; Shih-jhan Zeng; John Ta Hsu; Jim-Tong Horng; Hong-ming Yang; Shin-Ru Shih; Yu-ting Chu; Tzong-Yuan Wu
Amantadine as a regulator of internal ribosome entry site.
Acta pharmacologica Sinica 2008;29(11):1327-33.
2008: Chiayn Chiang; Guang-Wu Chen; Shin-Ru Shih
Mutations at alternative 5' splice sites of M1 mRNA negatively affect influenza A virus viability and growth rate.
Journal of virology 2008;82(21):10873-86.
2008: Jing-Yi Lin; Mei-Ling Li; Peng-Nien Huang; Kun-Yi Chien; Jim-Tong Horng; Shin-Ru Shih
Heterogeneous nuclear ribonuclear protein K interacts with the enterovirus 71 5' untranslated region and participates in virus replication.
The Journal of general virology 2008;89(Pt 10):2540-9.
2008: Hung-Yao Ho; Mei-Ling Cheng; Shiue-Fen Weng; Lo Chang; Tsun-Tsun Yeh; Shin-Ru Shih; Daniel Tsun-Yee Chiu
Glucose-6-phosphate dehydrogenase deficiency enhances enterovirus 71 infection.
The Journal of general virology 2008;89(Pt 9):2080-9.
2008: Chih-Jung Kuo; Jiun-Jie Shie; Jim-Min Fang; Guei-Rung Yen; John T A Hsu; Hun-Ge Liu; Sung-Nain Tseng; Shih-Cheng Chang; Ching-Yin Lee; Shin-Ru Shih; Po-Huang Liang
Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents.
Bioorganic & medicinal chemistry 2008;16(15):7388-98.
2008: Wen-Chen Li; Shin-Ru Shih; Yhu-Chering Huang; Guang-Wu Chen; Shih-Cheng Chang; Mei-Jen Hsiao; Kuo-Chien Tsao; Tzou-Yien Lin
Clinical and genetic characterization of severe influenza B-associated diseases during an outbreak in Taiwan.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2008;42(1):45-51.
2008: Tzu-Chun Chen; Shu-Cheng Liu; Peng-Nien Huang; Hwan-You Chang; Jyh-Haur Chern; Shin-Ru Shih
Antiviral activity of pyridyl imidazolidinones against enterovirus 71 variants.
Journal of biomedical science 2008;15(3):291-300.
2008: Jhih-Wei Jian; Guang-Wu Chen; Cheng-Tsung Lai; Li-Ching Hsu; Pei-Jer Chen; Steve Hsu-Sung Kuo; Ho-Sheng Wu; Shin-Ru Shih
Genetic and epidemiological analysis of influenza virus epidemics in Taiwan during 2003 to 2006.
Journal of clinical microbiology 2008;46(4):1426-34.
2008: Jin-Ching Lee; Shin-Ru Shih; Ten-Yuan Chang; Huan-Yi Tseng; Ya-Feng Shih; Kuei-Jung Yen; Wei-Chun Chen; Jiun-Jie Shie; Jim-Min Fang; Po-Huang Liang; Yu-Sheng Chao; John T A Hsu
A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71.
Analytical biochemistry 2008;375(1):115-23.
2008: Yi-Hsuan Wu; Ching-Ping Tseng; Mei-Ling Cheng; Hung-Yao Ho; Shin-Ru Shih; Daniel Tsun-Yee Chiu
Glucose-6-phosphate dehydrogenase deficiency enhances human coronavirus 229E infection.
The Journal of infectious diseases 2008;197(6):812-6.
2008: Shin-Ru Shih; Kuo-Feng Weng; Victor Stollar; Mei-Ling Li
Viral protein synthesis is required for Enterovirus 71 to induce apoptosis in human glioblastoma cells.
Journal of neurovirology 2008;14(1):53-61.
2007: Guang-Wu Chen; Shin-Ru Shih; Mei-Ren Hsiao; Shih-Cheng Chang; Shu-Hung Lin; Chien-Feng Sun; Kuo-Chien Tsao
Multiple genotypes of influenza B viruses cocirculated in Taiwan in 2004 and 2005.
Journal of clinical microbiology 2007;45(5):1515-22.
2007: Chin Li; Hongtao Wang; Shin-Ru Shih; Tzu-Chun Chen; Mei-Ling Li
The efficacy of viral capsid inhibitors in human enterovirus infection and associated diseases.
Current medicinal chemistry 2007;14(8):847-56.
2006: Shih-Cheng Chang; Guang-Wu Chen; Chee-Keng Mok; Kuo-Chien Tsao; Chung-Guei Huang; Ya-Ling Huang; Shin-Ru Shih
Subtyping of influenza A isolates in Taiwan--2003 to 2004.
Journal of the Formosan Medical Association = Taiwan yi zhi 2006;105(11):895-910.
2006: Guang-Wu Chen; Shih-Cheng Chang; Chee-Keng Mok; Yu-Luan Lo; Yu-Nong Kung; Ji-Hung Huang; Yun-Han Shih; Ji-Yi Wang; Chiayn Chiang; Chi-Jene Chen; Shin-Ru Shih
Genomic signatures of human versus avian influenza A viruses.
Emerging infectious diseases 2006;12(9):1353-60.
2006: Tsan-Chi Ceiba Chen; Guang-Wu Chen; Chao A Hsiung; Jyh-Yuan Yang; Shin-Ru Shih; Yiu-Kay Lai; Jyh-Lyh Juang
Combining multiplex reverse transcription-PCR and a diagnostic microarray to detect and differentiate enterovirus 71 and coxsackievirus A16.
Journal of clinical microbiology 2006;44(6):2212-9.
2006: Shih-Cheng Chang; Yi-Ying Cheng; Shin-Ru Shih
Avian influenza virus: the threat of a pandemic.
Chang Gung medical journal 2006;29(2):130-4.
2006: Yao-Chi Chung; Jen-Huang Huang; Chia-Wei Lai; Heng-Chun Sheng; Shin-Ru Shih; Mei-Shang Ho; Yu-Chen Hu
Expression, purification and characterization of enterovirus-71 virus-like particles.
World journal of gastroenterology : WJG 2006;12(6):921-7.
2006: John T A Hsu; Hsiang-Ching Wang; Guang-Wu Chen; Shin-Ru Shih
Antiviral drug discovery targeting to viral proteases.
Current pharmaceutical design 2006;12(11):1301-14.
2005: Guang-Wu Chen; Chao A Hsiung; Jyy-Ling Chyn; Shin-Ru Shih; Chi-Chung Wen; I-Shou Chang
Revealing molecular targets for enterovirus type 71 detection by profile hidden Markov models.
Virus genes 2005;31(3):337-47.
2005: Kuo-Chien Tsao; Guang-Wu Chen; Chung-Guei Huang; Ya-Ling Huang; Jing-Yi Lin; Chee-Keng Mok; Mok-Chee Keng; Chien-Feng Sun; Shin-Ru Shih
False positive antibody results against human T-cell lymphotropic virus in patients with severe acute respiratory syndrome.
Journal of medical virology 2005;77(3):331-6.
2005: Jyh-Haur Chern; Chih-Shiang Chang; Chia-Liang Tai; Yen-Chun Lee; Chung-Chi Lee; Iou-Jiun Kang; Ching-Yin Lee; Shin-Ru Shih
Synthesis and antipicornavirus activity of (R)- and (S)-1-[5-(4'-chlorobiphenyl-4-yloxy)-3-methylpentyl]-3-pyridin-4-yl-imidazolidin-2-one.
Bioorganic & medicinal chemistry letters 2005;15(19):4206-11.
2005: Jin-Ching Lee; Tzong-Yuan Wu; Chien-Fu Huang; Feng-Mine Yang; Shin-Ru Shih; John T A Hsu
High-efficiency protein expression mediated by enterovirus 71 internal ribosome entry site.
Biotechnology and bioengineering 2005;90(5):656-62.
2005: Chih-Shiang Chang; Ying-Ting Lin; Shin-Ru Shih; Chung-Chi Lee; Yen-Chun Lee; Chia-Liang Tai; Sung-Nien Tseng; Jyh-Haur Chern
Design, synthesis, and antipicornavirus activity of 1-[5-(4-arylphenoxy)alkyl]-3-pyridin-4-ylimidazolidin-2-one derivatives.
Journal of medicinal chemistry 2005;48(10):3522-35.
2005: Shin-Ru Shih; Guang-Wu Chen; Ching-Chun Yang; Weng-Zhi Yang; Ding-Ping Liu; Jih-Hui Lin; Shu-Chun Chiu; Haur-Young Chen; Kuo-Chien Tsao; Chung-Guei Huang; Ya-Ling Huang; Chee-Keng Mok; Chi-Jene Chen; Tzou-Yien Lin; Jen-Ren Wang; Chuan-Liang Kao; Kwei-Hsian Lin; Li-Kuang Chen; Hock-Liew Eng; Yung-Ching Liu; Po-Yen Chen; Jen-Shiou Lin; Jen-Hsien Wang; Cheng-Wen Lin; Yu-Jiun Chan; Jang-Jih Lu; Chao A Hsiung; Pei-Jer Chen; Ih-Jen Su
Laboratory-based surveillance and molecular epidemiology of influenza virus in Taiwan.
Journal of clinical microbiology 2005;43(4):1651-61.
2004: Shih-Cheng Chang; Jing-Yi Lin; Lily Yen-cheng Lo; Mei-Ling Li; Shin-Ru Shih
Diverse apoptotic pathways in enterovirus 71-infected cells.
Journal of neurovirology 2004;10(6):338-49.
2004: Jyh-Haur Chern; Chung-Chi Lee; Chih-Shiang Chang; Yen-Chun Lee; Chia-Liang Tai; Ying-Ting Lin; Kak-Shan Shia; Ching-Yin Lee; Shin-Ru Shih
Synthesis and antienteroviral activity of a series of novel, oxime ether-containing pyridyl imidazolidinones.
Bioorganic & medicinal chemistry letters 2004;14(20):5051-6.
2004: Shin-Ru Shih; Victor Stollar; Jing-Yi Lin; Shih-Cheng Chang; Guang-Wu Chen; Mei-Ling Li
Identification of genes involved in the host response to enterovirus 71 infection.
Journal of neurovirology 2004;10(5):293-304.
2004: Shin-Ru Shih; Mun-Chung Tsai; Sung-Nien Tseng; Kuo-Fang Won; Kak-Shan Shia; Wen-Tai Li; Jyh-Haur Chern; Guang-Wu Chen; Chung-Chi Lee; Yen-Chun Lee; Kuan-Chang Peng; Yu-Sheng Chao
Mutation in enterovirus 71 capsid protein VP1 confers resistance to the inhibitory effects of pyridyl imidazolidinone.
Antimicrobial agents and chemotherapy 2004;48(9):3523-9.
2004: Shin-Ru Shih; Shu-Jen Chen; Gholam Hossein Hakimelahi; Hsing-Jang Liu; Chen-Tso Tseng; Kak-Shan Shia
Selective human enterovirus and rhinovirus inhibitors: An overview of capsid-binding and protease-inhibiting molecules.
Medicinal research reviews 2004;24(4):449-74.
2004: Jyh-Haur Chern; Kak-Shan Shia; Tsu-An Hsu; Chia-Liang Tai; Chung-Chi Lee; Yen-Chun Lee; Chih-Shiang Chang; Sung-Nien Tseng; Shin-Ru Shih
Design, synthesis, and structure-activity relationships of pyrazolo[3,4-d]pyrimidines: a novel class of potent enterovirus inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(10):2519-25.
2004: Guang-Wu Chen; Ching-Chun Yang; Kuo-Chien Tsao; Chung-Guei Huang; Li-Ang Lee; Wen-Zhi Yang; Ya-Ling Huang; Tzou-Yien Lin; Shin-Ru Shih
Influenza A virus PB1-F2 gene in recent Taiwanese isolates.
Emerging infectious diseases 2004;10(4):630-6.
2004: Shin-Ru Shih; Chiayn Chiang; Tzu-Chun Chen; Cheng-Nan Wu; John T A Hsu; Jin-Ching Lee; Ming-Jing Hwang; Mei-Ling Li; Guang-Wu Chen; Mei-Shang Ho
Mutations at KFRDI and VGK domains of enterovirus 71 3C protease affect its RNA binding and proteolytic activities.
Journal of biomedical science 2004;11(2):239-48.
2004: Luan-Yin Chang; Kuo-Chien Tsao; Shao-Hsuan Hsia; Shin-Ru Shih; Chung-Guei Huang; Wing-Kai Chan; Kuang-Hung Hsu; Tsui-Yen Fang; Yhu-Chering Huang; Tzou-Yien Lin
Transmission and clinical features of enterovirus 71 infections in household contacts in Taiwan.
JAMA : the journal of the American Medical Association 2004;291(2):222-7.
2003: Shin-Ru Shih; Yih-Weng Wang; Guang-Wu Chen; Luan-Yin Chang; Tzou-Yien Lin; Mei-Chen Tseng; Chiayn Chiang; Kuo-Chien Tsao; Chung-Guei Huang; Mei-Ren Shio; Jui-Hung Tai; Shin-Hwan Wang; Rei-Lin Kuo; Wu-Tse Liu
Serotype-specific detection of enterovirus 71 in clinical specimens by DNA microchip array.
Journal of virological methods 2003;111(1):55-60.
2003: Shin-Ru Shih; Kun-Nan Tsai; Yi-Shuane Li; Chuang-Chun Chueh; Err-Cheng Chan
Inhibition of enterovirus 71-induced apoptosis by allophycocyanin isolated from a blue-green alga Spirulina platensis.
Journal of medical virology 2003;70(1):119-25.
2002: Kuo-Chien Tsao; Err-Cheng Chan; Luan-Yin Chang; Pi-Yueh Chang; Chung-Guei Huang; Yu-Ping Chen; Shih-Cheng Chang; Tzou-Yien Lin; Chien-Feng Sun; Shin-Ru Shih
Responses of IgM for enterovirus 71 infection.
Journal of medical virology 2002;68(4):574-80.
2002: Ya-Ching Lin; Cheng-Nan Wu; Shin-Ru Shih; Mei-Shang Ho
Characterization of a Vero cell-adapted virulent strain of enterovirus 71 suitable for use as a vaccine candidate.
Vaccine 2002;20(19-20):2485-93.
2002: Luan-Yin Chang; Chwan-Chuen King; Kuang-Hung Hsu; Hsiao-Chen Ning; Kuo-Chien Tsao; Chung-Chen Li; Yhu-Chering Huang; Shin-Ru Shih; Shu-Ti Chiou; Po-Yen Chen; Hong-Jen Chang; Tzou-Yien Lin
Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease/herpangina in children during an epidemic in Taiwan.
Pediatrics 2002;109(6):e88.
2002: Tzou-Yien Lin; Luan-Yin Chang; Shao-Hsuan Hsia; Yhu-Chering Huang; Cheng-Hsun Chiu; Chuen Hsueh; Shin-Ru Shih; Ching-Chuan Liu; Mei-Hwan Wu
The 1998 enterovirus 71 outbreak in Taiwan: pathogenesis and management.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2002;34 Suppl 2():S52-7.
2002: Kak-Shan Shia; Wen-Tai Li; Chung-Ming Chang; Ming-Chu Hsu; Jyh-Haur Chern; Max K Leong; Sung-Nien Tseng; Chung-Chi Lee; Yen-Chun Lee; Shu-Jen Chen; Kuan-Chang Peng; Huan-Yi Tseng; Yi-Ling Chang; Chia-Liang Tai; Shin-Ru Shih
Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: a novel class of potent and selective human enterovirus 71 inhibitors.
Journal of medicinal chemistry 2002;45(8):1644-55.
2002: Kuo-Chien Tsao; Pi-Yueh Chang; Hsiao-Chen Ning; Chien-Feng Sun; Tzou-Yien Lin; Luan-Yin Chang; Yhu-Chering Huang; Shin-Ru Shih
Use of molecular assay in diagnosis of hand, foot and mouth disease caused by enterovirus 71 or coxsackievirus A 16.
Journal of virological methods 2002;102(1-2):9-14.
2002: Mei-Ling Li; Tsu-An Hsu; Tzu-Chun Chen; Shih-Cheng Chang; Jin-Ching Lee; Chiann-Chyi Chen; Victor Stollar; Shin-Ru Shih
The 3C protease activity of enterovirus 71 induces human neural cell apoptosis.
Virology 2002;293(2):386-95.
2002: Fung-Jou Lu; Sung-Nien Tseng; M L Li; Shin-Ru Shih
In vitro anti-influenza virus activity of synthetic humate analogues derived from protocatechuic acid.
Archives of virology 2002;147(2):273-84.
2001: Cheng-Nan Wu; Y C Lin; C Fann; Nan-Shih Liao; Shin-Ru Shih; Mei-Shang Ho
Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus.
Vaccine 2001;20(5-6):895-904.
2001: Shin-Ru Shih; C N Lee; H R Tsai; Guang-Wu Chen; Kuo-Chien Tsao
Amantadine-resistant influenza A virus in Taiwan.
Journal of the Formosan Medical Association = Taiwan yi zhi 2001;100(9):608-12.
2000: Chuen Hsueh; Shih-Ming Jung; Shin-Ru Shih; Tseng-tong Kuo; W J Shieh; S Zaki; Tzou-Yien Lin; L Y Chang; H C Ning; D C Yen
Acute encephalomyelitis during an outbreak of enterovirus type 71 infection in Taiwan: report of an autopsy case with pathologic, immunofluorescence, and molecular studies.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2000;13(11):1200-5.
2000: Shin-Ru Shih; Mei-Shang Ho; Kwang-Huei Lin; S L Wu; Y T Chen; Cheng-Nan Wu; Tzou-Yien Lin; Luan-Yin Chang; Kuo-Chien Tsao; Hsiao-Chen Ning; Pi-Yueh Chang; S M Jung; Chuen Hsueh; K S Chang
Genetic analysis of enterovirus 71 isolated from fatal and non-fatal cases of hand, foot and mouth disease during an epidemic in Taiwan, 1998.
Virus research 2000;68(2):127-36.
2000: Shin-Ru Shih; Yi-Shuane Li; Chiuan-Chian Chiou; P C Suen; Tzou-Yien Lin; Luan-Yin Chang; Yhu-Chering Huang; Kuo-Chien Tsao; Hsiao-Chen Ning; T Z Wu; Err-Cheng Chan
Expression of capsid [correction of caspid] protein VP1 for use as antigen for the diagnosis of enterovirus 71 infection.
Journal of medical virology 2000;61(2):228-34.
1999: Luan-Yin Chang; Tzou-Yien Lin; Yhu-Chering Huang; Kuo-Chien Tsao; Shin-Ru Shih; M L Kuo; Hsiao-Chen Ning; P W Chung; C M Kang
Comparison of enterovirus 71 and coxsackie-virus A16 clinical illnesses during the Taiwan enterovirus epidemic, 1998.
The Pediatric infectious disease journal 1999;18(12):1092-6.
1999: Luan-Yin Chang; Tzou-Yien Lin; Kuang-Hung Hsu; Yhu-Chering Huang; Kuang-Lin Lin; Chuen Hsueh; Shin-Ru Shih; Hsiao-Chen Ning; Mao-Sheng Hwang; Huei-Shyong Wang; C Y Lee
Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease.
Lancet 1999;354(9191):1682-6.
1999: Monto Ho; E R Chen; Kuang-Hung Hsu; Shiing-Jer Twu; Kow-Tong Chen; S F Tsai; J R Wang; Shin-Ru Shih
An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group.
The New England journal of medicine 1999;341(13):929-35.
1999: Shin-Ru Shih; Kuo-Chien Tsao; Hsiao-Chen Ning; Yhu-Chering Huang; Tzou-Yien Lin
Diagnosis of respiratory tract viruses in 24 h by immunofluorescent staining of shell vial cultures containing Madin-Darby Canine Kidney (MDCK) cells.
Journal of virological methods 1999;81(1-2):77-81.
1998: Shin-Ru Shih; P C Suen; Y S Chen; S C Chang
A novel spliced transcript of influenza A/WSN/33 virus.
Virus genes 1998;17(2):179-83.