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Ali Shilatifard

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Chemicals & Drugs

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Methylation

Physiology

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TOP 3
Marc Alard Morgan; Ali Shilatifard
Medicine. (Poly)combing the pediatric cancer genome for answers.
Marc Alard Morgan; Ali Shilatifard
Drosophila SETs its sights on cancer: Trr/MLL3/4 COMPASS-like complexes in development and disease.
Lama Tarayrah; Hans-Martin Herz; Ali Shilatifard; Xin Chen
Histone demethylase dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche.

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All Publications

2013: Marc Alard Morgan; Ali Shilatifard
Medicine. (Poly)combing the pediatric cancer genome for answers.
Science (New York, N.Y.) 2013;340(6134):823-4.
2013: Marc Alard Morgan; Ali Shilatifard
Drosophila SETs its sights on cancer: Trr/MLL3/4 COMPASS-like complexes in development and disease.
Molecular and cellular biology 2013;33(9):1698-701.
2013: Lama Tarayrah; Hans-Martin Herz; Ali Shilatifard; Xin Chen
Histone demethylase dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche.
Development (Cambridge, England) 2013;140(5):1014-23.
2013: Chengqi Lin; Zhuojuan Luo; Alexander S Garruss; Fengli Guo; Ali Shilatifard
The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation.
Cell 2013;152(1-2):144-56.
2012: Hans-Martin Herz; Kaiwei Liang; Kristen Mickey; Man Mohan; Yoh-hei Takahashi; C Peter Verrijzer; Olaf Voets; Alexander S Garruss; Ali Shilatifard
Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4.
Genes & development 2012;26(23):2604-20.
2012: Zhuojuan Luo; Chengqi Lin; Ali Shilatifard
The super elongation complex (SEC) family in transcriptional control.
Nature reviews. Molecular cell biology 2012;13(9):543-7.
2012: Zhuojuan Luo; Stacy Marshall; Nima Mohaghegh; Laurence Florens; Alexander S Garrett; Erin Guest; Chengqi Lin; Selene Swanson; Michael P Washburn; Ali Shilatifard
The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output.
Molecular and cellular biology 2012;32(13):2608-17.
2012: Jung-Shin Lee; B Franklin Pugh; Christopher Seidel; Alexander S Garrett; Deqing Hu; Jessica Jackson; Yoh-hei Takahashi; Kuangyu Yen; Ali Shilatifard
Codependency of H2B monoubiquitination and nucleosome reassembly on Chd1.
Genes & development 2012;26(9):914-9.
2012: Hans-Martin Herz; Caitlynn Miller; Man Mohan; Christopher Seidel; Ramin Shiekhattar; David Casto; Laurence Florens; Alexander S Garrett; Jeffrey S Haug; Michael P Washburn; Masamitsu Yamaguchi; Ying Zhang; Ali Shilatifard
Polycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila.
Molecular and cellular biology 2012;32(9):1683-93.
2012: Man Mohan; Hans-Martin Herz; Ali Shilatifard
SnapShot: Histone lysine methylase complexes.
Cell 2012;149(2):498-498.e1.
2012: Ali Shilatifard
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.
Annual review of biochemistry 2012;81():65-95.
2011: Julia M Schulze; Ali Shilatifard; Shima Nakanishi; Eldon Emberly; Arvind Gupta; Thomas Hentrich; Michael S Kobor
Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123.
Genes & development 2011;25(21):2242-7.
2011: Man Mohan; Edwin R Smith; Michael P Washburn; Ying Zhang; Joel C Eissenberg; Laurence Florens; Hans-Martin Herz; Jessica Jackson; Ali Shilatifard
The COMPASS family of H3K4 methylases in Drosophila.
Molecular and cellular biology 2011;31(21):4310-8.
2011: Steven Henikoff; Ali Shilatifard
Histone modification: cause or cog?
Trends in genetics : TIG 2011;27(10):389-96.
2011: Chengqi Lin; Christopher Seidel; Edwin R Smith; Bony De Kumar; Alexander S Garrett; Madelaine Gogol; Robb Krumlauf; Ali Shilatifard
Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC).
Genes & development 2011;25(14):1486-98.
2011: Hidehisa Takahashi; Chieri Tomomori-Sato; Michael Washburn; Charles A S Banks; Ronald C Conaway; Laurence Florens; Stephanie E Kong; Chengqi Lin; Skylar A Martin-Brown; Tari J Parmely; Shigeo Sato; Chris W Seidel; Ali Shilatifard; Edwin R Smith; Selene K Swanson; Henrietta Szutorisz; Joan Weliky Conaway
Human mediator subunit MED26 functions as a docking site for transcription elongation factors.
Cell 2011;146(1):92-104.
2011: Yao Yu; Madhusudhan Srinivasan; Shima Nakanishi; Janet Leatherwood; Ali Shilatifard; Rolf Sternglanz
A conserved patch near the C terminus of histone H4 is required for genome stability in budding yeast.
Molecular and cellular biology 2011;31(11):2311-25.
2011: Yoh-hei Takahashi; Julia M Schulze; Jessica Jackson; Thomas Hentrich; Chris Seidel; Sue L Jaspersen; Michael S Kobor; Ali Shilatifard
Dot1 and histone H3K79 methylation in natural telomeric and HM silencing.
Molecular cell 2011;42(1):118-26.
2011: Edwin Smith; Chengqi Lin; Ali Shilatifard
The super elongation complex (SEC) and MLL in development and disease.
Genes & development 2011;25(7):661-72.
2011: Ali Shilatifard; Peter Verrijzer
Chromosomes and gene expression mechanisms: peeling away the many layers of transcriptional control.
Current opinion in genetics & development 2011;21(2):121-3.
2010: Edwin Smith; Ali Shilatifard
The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes.
Molecular cell 2010;40(5):689-701.
2010: Man Mohan; Chengqi Lin; Erin Guest; Ali Shilatifard
Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis.
Nature reviews. Cancer 2010;10(10):721-8.
2010: Jung-Shin Lee; Edwin Smith; Ali Shilatifard
The language of histone crosstalk.
Cell 2010;142(5):682-5.
2010: Hans-Martin Herz; Ali Shilatifard
The JARID2-PRC2 duality.
Genes & development 2010;24(9):857-61.
2010: Hans-Martin Herz; Laurence D Madden; Zhihong Chen; Clare Bolduc; Eugene Buff; Ravi Gupta; Ramana V Davuluri; Ali Shilatifard; Iswar K Hariharan; Andreas Bergmann
The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila.
Molecular and cellular biology 2010;30(10):2485-97.
2010: Man Mohan; Hans-Martin Herz; Yoh-hei Takahashi; Chengqi Lin; Ka Chun Lai; Ying Zhang; Michael P Washburn; Laurence Florens; Ali Shilatifard
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom).
Genes & development 2010;24(6):574-89.
2010: Joel C Eissenberg; Ali Shilatifard
Histone H3 lysine 4 (H3K4) methylation in development and differentiation.
Developmental biology 2010;339(2):240-9.
2010: Chengqi Lin; Edwin R Smith; Hidehisa Takahashi; Ka Chun Lai; Skylar Martin-Brown; Laurence Florens; Michael P Washburn; Joan W Conaway; Ronald C Conaway; Ali Shilatifard
AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.
Molecular cell 2010;37(3):429-37.
2010: Yoh-hei Takahashi; Ali Shilatifard
Structural basis for H3K4 trimethylation by yeast Set1/COMPASS.
Advances in enzyme regulation 2010;50(1):104-10.
2009: Pengfei Wang; Chengqi Lin; Edwin R Smith; Hong Guo; Brian W Sanderson; Min Wu; Madelaine Gogol; Tara Alexander; Christopher Seidel; Leanne M Wiedemann; Kai Ge; Robb Krumlauf; Ali Shilatifard
Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.
Molecular and cellular biology 2009;29(22):6074-85.
2009: Raymond Camahort; Manjunatha Shivaraju; Mark Mattingly; Bing Li; Shima Nakanishi; Dongxiao Zhu; Ali Shilatifard; Jerry L Workman; Jennifer L Gerton
Cse4 is part of an octameric nucleosome in budding yeast.
Molecular cell 2009;35(6):794-805.
2009: Julia M Schulze; Jessica Jackson; Shima Nakanishi; Jennifer M Gardner; Thomas Hentrich; Jeff Haug; Mark Johnston; Sue L Jaspersen; Michael S Kobor; Ali Shilatifard
Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation.
Molecular cell 2009;35(5):626-41.
2009: Hans-Martin Herz; Shima Nakanishi; Ali Shilatifard
The curious case of bivalent marks.
Developmental cell 2009;17(3):301-3.
2009: Shima Nakanishi; Jung-Shin Lee; Kathryn E Gardner; Jennifer M Gardner; Yoh-hei Takahashi; Mahesh B Chandrasekharan; Zu-Wen Sun; Mary Ann Osley; Brian D Strahl; Sue L Jaspersen; Ali Shilatifard
Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1.
The Journal of cell biology 2009;186(3):371-7.
2009: Raymond C Trievel; Ali Shilatifard
WDR5, a complexed protein.
Nature structural & molecular biology 2009;16(7):678-80.
2009: Yoh-hei Takahashi; Jung-Shin Lee; Selene K Swanson; Anita Saraf; Laurence Florens; Michael Washburn; Raymond C Trievel; Ali Shilatifard
Regulation of H3K4 trimethylation via Cps40 (Spp1) of COMPASS is monoubiquitination independent: implication for a Phe/Tyr switch by the catalytic domain of Set1.
Molecular and cellular biology 2009;29(13):3478-86.
2009: Weiwei Dang; Kristan K Steffen; Rocco Perry; Jean A Dorsey; F Brad Johnson; Ali Shilatifard; Matt Kaeberlein; Brian K Kennedy; Shelley L Berger
Histone H4 lysine 16 acetylation regulates cellular lifespan.
Nature 2009;459(7248):802-7.
2009: Jaehoon Kim; Mohamed Guermah; Robert K McGinty; Jung-Shin Lee; Zhanyun Tang; Thomas A Milne; Ali Shilatifard; Tom W Muir; Robert G Roeder
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.
Cell 2009;137(3):459-71.
2009: Shelley L Berger; Tony Kouzarides; Ramin Shiekhattar; Ali Shilatifard
An operational definition of epigenetics.
Genes & development 2009;23(7):781-3.
2009: Bing Li; Jessica Jackson; Matthew D Simon; Brian Fleharty; Madelaine Gogol; Chris Seidel; Jerry L Workman; Ali Shilatifard
Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription.
The Journal of biological chemistry 2009;284(12):7970-6.
2009: Edwin Smith; Ali Shilatifard
Developmental biology. Histone cross-talk in stem cells.
Science (New York, N.Y.) 2009;323(5911):221-2.
2009: Jessica Jackson; Ali Shilatifard
Global proteomic analysis of Saccharomyces cerevisiae identifies molecular pathways of histone modifications.
Methods in molecular biology (Clifton, N.J.) 2009;548():175-86.
2008: Min Wu; Peng Fei Wang; Jung-Shin Lee; Skylar Martin-Brown; Laurence Florens; Michael Washburn; Ali Shilatifard
Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.
Molecular and cellular biology 2008;28(24):7337-44.
2008: Shima Nakanishi; Brian W Sanderson; Kym M Delventhal; William D Bradford; Karen Staehling-Hampton; Ali Shilatifard
A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation.
Nature structural & molecular biology 2008;15(8):881-8.
2008: Edwin R Smith; Benjamin Winter; Joel C Eissenberg; Ali Shilatifard
Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(25):8575-9.
2008: Ali Shilatifard
Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation.
Current opinion in cell biology 2008;20(3):341-8.
2008: Pengfei Wang; Michael R Bowl; Stephanie Bender; Jun Peng; Leslie Farber; Jindong Chen; Asif Ali; Zhongfa Zhang; ARTHUR S ALBERTS; Rajesh V Thakker; Ali Shilatifard; Bart Williams; Bin Tean Teh
Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice.
Molecular and cellular biology 2008;28(9):2930-40.
2008: Edwin R Smith; Min Gyu Lee; Benjamin Winter; Nathan M Droz; Joel C Eissenberg; Ramin Shiekhattar; Ali Shilatifard
Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II.
Molecular and cellular biology 2008;28(3):1041-6.
2007: Jung-Shin Lee; Abhijit Shukla; Jessica Schneider; Selene K Swanson; Michael Washburn; Laurence Florens; Sukesh R Bhaumik; Ali Shilatifard
Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS.
Cell 2007;131(6):1084-96.
2007: C David Allis; Shelley L Berger; Jacques Cote; Sharon Dent; Thomas Jenuwien; Tony Kouzarides; Lorraine Pillus; Danny Reinberg; Yang Shi; Ramin Shiekhattar; Ali Shilatifard; Jerry Workman; Yi Zhang
New nomenclature for chromatin-modifying enzymes.
Cell 2007;131(4):633-6.
2007: Sukesh R Bhaumik; Edwin Smith; Ali Shilatifard
Covalent modifications of histones during development and disease pathogenesis.
Nature structural & molecular biology 2007;14(11):1008-16.
2007: Kristin Ingvarsdottir; Chris Edwards; Min Gyu Lee; Jung-Shin Lee; David C Schultz; Ali Shilatifard; Ramin Shiekhattar; Shelley L Berger
Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae.
Molecular and cellular biology 2007;27(22):7856-64.
2007: Edwin Smith; Ali Shilatifard
The A, B, Gs of silencing.
Genes & development 2007;21(10):1141-4.
2007: Jung-Shin Lee; Ali Shilatifard
A site to remember: H3K36 methylation a mark for histone deacetylation.
Mutation research 2007;618(1-2):130-4.
2007: Joel C Eissenberg; Min Gyu Lee; Jessica Schneider; Anne Ilvarsonn; Ramin Shiekhattar; Ali Shilatifard
The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase.
Nature structural & molecular biology 2007;14(4):344-6.
2007: Min Gyu Lee; Jessica Norman; Ali Shilatifard; Ramin Shiekhattar
Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein.
Cell 2007;128(5):877-87.
2007: Joel C Eissenberg; Ali Shilatifard; Nikolay Dorokhov; Dorian E Michener
Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment.
Molecular genetics and genomics : MGG 2007;277(2):101-14.
2007: Adam Wood; Abhijit Shukla; Jessica Schneider; Jung-Shin Lee; Julie D Stanton; Tiffany Dzuiba; Selene K Swanson; Laurence Florens; Michael Washburn; John J Wyrick; Sukesh R Bhaumik; Ali Shilatifard
Ctk complex-mediated regulation of histone methylation by COMPASS.
Molecular and cellular biology 2007;27(2):709-20.
2006: Jessica Schneider; Pratibha Bajwa; Farley C Johnson; Sukesh R Bhaumik; Ali Shilatifard
Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II.
The Journal of biological chemistry 2006;281(49):37270-4.
2006: Kristy D Wendt; Ali Shilatifard
Packing for the germy: the role of histone H4 Ser1 phosphorylation in chromatin compaction and germ cell development.
Genes & development 2006;20(18):2487-91.
2006: Melissa M Steward; Jung-Shin Lee; Aisling O'Donovan; Matt Wyatt; Bradley E Bernstein; Ali Shilatifard
Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes.
Nature structural & molecular biology 2006;13(9):852-4.
2006: Kristen Tenney; Mark Gerber; Anne Ilvarsonn; Jessica Schneider; Maria Gause; Dale Dorsett; Joel C Eissenberg; Ali Shilatifard
Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):11970-4.
2006: Rushad Pavri; Bing Zhu; Guohong Li; Patrick Trojer; Subhrangsu Mandal; Ali Shilatifard; Danny Reinberg
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.
Cell 2006;125(4):703-17.
2006: Adam Wood; Ali Shilatifard
Bur1/Bur2 and the Ctk complex in yeast: the split personality of mammalian P-TEFb.
Cell cycle (Georgetown, Tex.) 2006;5(10):1066-8.
2006: Joel C Eissenberg; Ali Shilatifard
Leaving a mark: the many footprints of the elongating RNA polymerase II.
Current opinion in genetics & development 2006;16(2):184-90.
2006: Nevan J Krogan; Gerard Cagney; Haiyuan Yu; Gouqing Zhong; Xinghua Guo; Alexandr Ignatchenko; Joyce Li; Shuye Pu; Nira Datta; Aaron P Tikuisis; Thanuja Punna; José M Peregrín-Alvarez; Michael Shales; Xin Zhang; Michael Davey; Mark D Robinson; Alberto Paccanaro; James E Bray; Anthony Sheung; Bryan Beattie; Dawn P Richards; Veronica Canadien; Atanas Lalev; Frank Mena; Peter Wong; Andrei Starostine; Myra M Canete; James Vlasblom; Samuel Wu; Chris Orsi; Sean R Collins; Shamanta Chandran; Robin Haw; Jennifer J Rilstone; Kiran Gandi; Natalie J Thompson; Gabe Musso; Peter St Onge; Shaun Ghanny; Mandy H Y Lam; Gareth Butland; Amin M Altaf-Ul; Shigehiko Kanaya; Ali Shilatifard; Erin O'Shea; Jonathan S Weissman; C James Ingles; Timothy R Hughes; John Parkinson; Mark Gerstein; Shoshana J Wodak; Andrew Emili; Jack F Greenblatt
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
Nature 2006;440(7084):637-43.
2006: Jessica Schneider; Ali Shilatifard
Histone demethylation by hydroxylation: chemistry in action.
ACS chemical biology 2006;1(2):75-81.
2006: Adam Wood; Ali Shilatifard
Transcriptional blackjack with p21.
Genes & development 2006;20(6):643-7.
2006: Ali Shilatifard
Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression.
Annual review of biochemistry 2006;75():243-69.
2005: Adam Wood; Jessica Schneider; Jim Dover; Mark Johnston; Ali Shilatifard
The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS.
Molecular cell 2005;20(4):589-99.
2005: Christopher Wynder; Mohamed-Ali Hakimi; Jonathan A Epstein; Ali Shilatifard; Ramin Shiekhattar
Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation.
Nature cell biology 2005;7(11):1113-7.
2005: David Baillat; Mohamed-Ali Hakimi; Anders M Näär; Ali Shilatifard; Neil Cooch; Ramin Shiekhattar
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.
Cell 2005;123(2):265-76.
2005: Adam Wood; Ali Shilatifard
Guided by COMPASS on a journey through chromosome segregation.
Nature structural & molecular biology 2005;12(10):839-40.
2005: Jessica Schneider; Adam Wood; Jung-Shin Lee; Rebecca Schuster; Jeff Dueker; Courtney Maguire; Selene K Swanson; Laurence Florens; Michael Washburn; Ali Shilatifard
Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression.
Molecular cell 2005;19(6):849-56.
2005: Mark A Gerber; Ali Shilatifard; Joel C Eissenberg
Mutational analysis of an RNA polymerase II elongation factor in Drosophila melanogaster.
Molecular and cellular biology 2005;25(17):7803-11.
2005: Adam Wood; Jessica Schneider; Ali Shilatifard
Cross-talking histones: implications for the regulation of gene expression and DNA repair.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2005;83(4):460-7.
2005: Stephanie E Kong; Charles A S Banks; Ali Shilatifard; Joan Weliky Conaway; Ronald C Conaway
ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10094-8.
2005: Dmitri Wiederschain; Hidehiko Kawai; Ali Shilatifard; Zhi-Min Yuan
Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage.
The Journal of biological chemistry 2005;280(26):24315-21.
2005: Kristen Tenney; Ali Shilatifard
A COMPASS in the voyage of defining the role of trithorax/MLL-containing complexes: linking leukemogensis to covalent modifications of chromatin.
Journal of cellular biochemistry 2005;95(3):429-36.
2005: N C Tolga Emre; Kristin Ingvarsdottir; Anastasia Wyce; Adam Wood; Nevan J Krogan; Karl W Henry; Keqin Li; Ronen Marmorstein; Jack F Greenblatt; Ali Shilatifard; Shelley L Berger
Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing.
Molecular cell 2005;17(4):585-94.
2005: Mark Gerber; Kristen Tenney; Joan Weliky Conaway; Ronald C Conaway; Joel C Eissenberg; Ali Shilatifard
Regulation of heat shock gene expression by RNA polymerase II elongation factor, Elongin A.
The Journal of biological chemistry 2005;280(6):4017-20.
2004: Mark Gerber; Joel C Eissenberg; Stephanie Kong; Kristen Tenney; Joan Weliky Conaway; Ronald C Conaway; Ali Shilatifard
In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development.
Molecular and cellular biology 2004;24(22):9911-9.
2004: Ali Shilatifard
Transcriptional elongation control by RNA polymerase II: a new frontier.
Biochimica et biophysica acta 2004;1677(1-3):79-86.
2004: Jessica Schneider; Jim Dover; Mark Johnston; Ali Shilatifard
Global proteomic analysis of S. cerevisiae (GPS) to identify proteins required for histone modifications.
Methods in enzymology 2004;377():227-34.
2004: Adam Wood; Ali Shilatifard
Posttranslational modifications of histones by methylation.
Advances in protein chemistry 2004;67():201-22.
2003: Karl W Henry; Anastasia Wyce; Wan-Sheng Lo; Laura J Duggan; N C Tolga Emre; Cheng-Fu Kao; Lorraine Pillus; Ali Shilatifard; Mary Ann Osley; Shelley L Berger
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.
Genes & development 2003;17(21):2648-63.
2003: Adam Wood; Jessica Schneider; Jim Dover; Mark Johnston; Ali Shilatifard
The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p.
The Journal of biological chemistry 2003;278(37):34739-42.
2003: Mark Gerber; Ali Shilatifard
Transcriptional elongation by RNA polymerase II and histone methylation.
The Journal of biological chemistry 2003;278(29):26303-6.
2003: Dmitri Wiederschain; Hidehiko Kawai; JiJie Gu; Ali Shilatifard; Zhi-Min Yuan
Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL.
Molecular and cellular biology 2003;23(12):4230-46.
2003: Nevan J Krogan; Minkyu Kim; Amy Tong; Ashkan Golshani; Gerard Cagney; Veronica Canadien; Dawn P Richards; Bryan K Beattie; Andrew Emili; Charles Boone; Ali Shilatifard; Stephen Buratowski; Jack Greenblatt
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II.
Molecular and cellular biology 2003;23(12):4207-18.
2003: Nevan J Krogan; Jim Dover; Adam Wood; Jessica Schneider; Jonathan Heidt; Marry Ann Boateng; Kimberly Dean; Owen W Ryan; Ashkan Golshani; Mark Johnston; Jack F Greenblatt; Ali Shilatifard
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.
Molecular cell 2003;11(3):721-9.
2003: Stephanie E Kong; Ali Shilatifard; Ronald C Conaway; Joan Weliky Conaway
Preparation and assay of RNA polymerase II elongation factors elongin and ELL.
Methods in enzymology 2003;371():276-83.
2003: Ali Shilatifard; Ronald C Conaway; Joan Weliky Conaway
The RNA polymerase II elongation complex.
Annual review of biochemistry 2003;72():693-715.
2003: Adam Wood; Nevan J Krogan; Jim Dover; Jessica Schneider; Jonathan Heidt; Marry Ann Boateng; Kimberly Dean; Ashkan Golshani; Yi Zhang; Jack F Greenblatt; Mark Johnston; Ali Shilatifard
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.
Molecular cell 2003;11(1):267-74.
2002: Nevan J Krogan; Minkyu Kim; Seong Hoon Ahn; Guoqing Zhong; Michael S Kobor; Gerard Cagney; Andrew Emili; Ali Shilatifard; Stephen Buratowski; Jack F Greenblatt
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach.
Molecular and cellular biology 2002;22(20):6979-92.
2002: Jim Dover; Jessica Schneider; Mary Anne Tawiah-Boateng; Adam Wood; Kimberly Dean; Mark Johnston; Ali Shilatifard
Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.
The Journal of biological chemistry 2002;277(32):28368-71.
2002: Joel C Eissenberg; Jiyan Ma; Mark A Gerber; Alan Christensen; James A Kennison; Ali Shilatifard
dELL is an essential RNA polymerase II elongation factor with a general role in development.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):9894-9.
2002: Nevan J Krogan; Jim Dover; Shahram Khorrami; Jack F Greenblatt; Jessica Schneider; Mark Johnston; Ali Shilatifard
COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression.
The Journal of biological chemistry 2002;277(13):10753-5.
2001: T Miller; Nevan J Krogan; J Dover; H Erdjument-Bromage; Paul Tempst; M Johnston; Jack F Greenblatt; Ali Shilatifard
COMPASS: a complex of proteins associated with a trithorax-related SET domain protein.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):12902-7.
2001: M Gerber; J Ma; K Dean; Joel C Eissenberg; Ali Shilatifard
Drosophila ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites in vivo.
The EMBO journal 2001;20(21):6104-14.
2001: Takumi Kamura; D Burian; Qin Yan; SL Schmidt; William Stratton Lane; E Querido; Philip E Branton; Ali Shilatifard; Ronald C Conaway; Joan Weliky Conaway
Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.
The Journal of biological chemistry 2001;276(32):29748-53.
2001: B J Elmendorf; Ali Shilatifard; Qin Yan; Joan Weliky Conaway; Ronald C Conaway
Transcription factors TFIIF, ELL, and Elongin negatively regulate SII-induced nascent transcript cleavage by non-arrested RNA polymerase II elongation intermediates.
The Journal of biological chemistry 2001;276(25):23109-14.
2001: Takumi Kamura; D Burian; H Khalili; SL Schmidt; Sanai Sato; W J Liu; Michael N Conrad; Ronald C Conaway; Joan Weliky Conaway; Ali Shilatifard
Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose.
The Journal of biological chemistry 2001;276(19):16528-33.
2001: Ricky Johnstone; M Gerber; T Landewe; Ann E Tollefson; William S M Wold; Ali Shilatifard
Functional analysis of the leukemia protein ELL: evidence for a role in the regulation of cell growth and survival.
Molecular and cellular biology 2001;21(5):1672-81.
2000: Jorge F DiMartino; T Miller; Paul M Ayton; T Landewe; Jay L Hess; Michael L Cleary; Ali Shilatifard
A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL.
Blood 2000;96(12):3887-93.
2000: T Miller; K Williams; Ricky Johnstone; Ali Shilatifard
Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3.
The Journal of biological chemistry 2000;275(41):32052-6.
2000: Joan Weliky Conaway; Ali Shilatifard; Arik Dvir; Ronald C Conaway
Control of elongation by RNA polymerase II.
Trends in biochemical sciences 2000;25(8):375-80.
2000: Corrado Caslini; Ali Shilatifard; L Yang; Jay L Hess
The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2797-802.
2000: Luis M Schang; G J Hwang; Brian David Dynlacht; David W Speicher; Andrew Bantly; Priscilla A Schaffer; Ali Shilatifard; H Ge; Ramin Shiekhattar
Human PC4 is a substrate-specific inhibitor of RNA polymerase II phosphorylation.
The Journal of biological chemistry 2000;275(9):6071-4.
1999: Amy E Schmidt; T Miller; SL Schmidt; Ramin Shiekhattar; Ali Shilatifard
Cloning and characterization of the EAP30 subunit of the ELL complex that confers derepression of transcription by RNA polymerase II.
The Journal of biological chemistry 1999;274(31):21981-5.
1999: Christopher S Brower; Ali Shilatifard; T Mather; Takumi Kamura; Y Takagi; D Haque; A Treharne; SI Foundling; Joan Weliky Conaway; Ronald C Conaway
The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C.
The Journal of biological chemistry 1999;274(19):13629-36.
1999: Daniel Bochar; Z Q Pan; R Knights; Robert P Fisher; Ali Shilatifard; Ramin Shiekhattar
Inhibition of transcription by the trimeric cyclin-dependent kinase 7 complex.
The Journal of biological chemistry 1999;274(19):13162-6.
1998: Ali Shilatifard
Factors regulating the transcriptional elongation activity of RNA polymerase II.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(14):1437-46.
1998: Ali Shilatifard
Identification and purification of the Holo-ELL complex. Evidence for the presence of ELL-associated proteins that suppress the transcriptional inhibitory activity of ELL.
The Journal of biological chemistry 1998;273(18):11212-7.
1998: Ali Shilatifard
The RNA polymerase II general elongation complex.
Biological chemistry 1998;379(1):27-31.
1997: Ali Shilatifard; D Haque; Ronald C Conaway; Joan Weliky Conaway
Structure and function of RNA polymerase II elongation factor ELL. Identification of two overlapping ELL functional domains that govern its interaction with polymerase and the ternary elongation complex.
The Journal of biological chemistry 1997;272(35):22355-63.
1997: Ali Shilatifard; DR Duan; D Haque; C Florence; W H Schubach; Joan Weliky Conaway; Ronald C Conaway
ELL2, a new member of an ELL family of RNA polymerase II elongation factors.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3639-43.
1997: Ali Shilatifard; Joan Weliky Conaway; Ronald C Conaway
Mechanism and regulation of transcriptional elongation and termination by RNA polymerase II.
Current opinion in genetics & development 1997;7(2):199-204.
1997: P A Prieto; R D Larsen; Moonjae Cho; H N Rivera; Ali Shilatifard; J B Lowe; Richard D Cummings; David Smith
Expression of human H-type alpha1,2-fucosyltransferase encoding for blood group H(O) antigen in Chinese hamster ovary cells. Evidence for preferential fucosylation and truncation of polylactosamine sequences.
The Journal of biological chemistry 1997;272(4):2089-97.
1996: T Aso; Ali Shilatifard; Joan Weliky Conaway; Ronald C Conaway
Transcription syndromes and the role of RNA polymerase II general transcription factors in human disease.
The Journal of clinical investigation 1996;97(7):1561-9.
1996: Ali Shilatifard; William Stratton Lane; K W Jackson; Ronald C Conaway; Joan Weliky Conaway
An RNA polymerase II elongation factor encoded by the human ELL gene.
Science (New York, N.Y.) 1996;271(5257):1873-6.
1995: Ali Shilatifard; Richard D Cummings
Sulphate release from keratan sulphate and heparan sulphate by bovine N-acetylglucosamine-6-sulphate sulphatase.
Glycobiology 1995;5(3):291-7.
1994: Ali Shilatifard; Richard D Cummings
Purification and characterization of N-acetylglucosamine-6-sulfate sulfatase from bovine kidney: evidence for the presence of a novel endosulfatase activity.
Biochemistry 1994;33(14):4273-82.
1993: Ali Shilatifard; R K Merkle; D E Helland; J L Welles; W A Haseltine; Richard D Cummings
Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine.
Journal of virology 1993;67(2):943-52.
1991: R K Merkle; D E Helland; J L Welles; Ali Shilatifard; W A Haseltine; Richard D Cummings
gp160 of HIV-I synthesized by persistently infected Molt-3 cells is terminally glycosylated: evidence that cleavage of gp160 occurs subsequent to oligosaccharide processing.
Archives of biochemistry and biophysics 1991;290(1):248-57.