FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Yosef Shiloh

Research Profile

Disorders

Chemicals & Drugs

Living Beings

Mouse

Physiology

Phenomena

Phosphorylation

Anatomy

Concepts & Ideas

Molecular Sequence Data

Co-author Network

Publications

TOP 3
Yosef Shiloh; Yael Ziv
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.
Yosef Shiloh; Yael Ziv
The ATM protein: the importance of being active.
Michal Kirshner; Gil Mandelbaum; Yosef Shiloh; Zhao-Qi Wang; Dan Frenkel; Ronit Galron; Ari Barzilai
Malfunctioning DNA damage response (DDR) leads to the degeneration of nigro-striatal pathway in mouse brain.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Yosef Shiloh (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Yosef Shiloh; Yael Ziv
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.
Nature reviews. Molecular cell biology 2013;14(4):197-210.
2012: Yosef Shiloh; Yael Ziv
The ATM protein: the importance of being active.
The Journal of cell biology 2012;198(3):273-5.
2012: Michal Kirshner; Gil Mandelbaum; Yosef Shiloh; Zhao-Qi Wang; Dan Frenkel; Ronit Galron; Ari Barzilai
Malfunctioning DNA damage response (DDR) leads to the degeneration of nigro-striatal pathway in mouse brain.
Journal of molecular neuroscience : MN 2012;46(3):554-68.
2011: Adva Levy-Barda; Zhengping Shao; Nicole van Vliet; Yael Ziv; David J Chen; Young Min Chung; Anthony J Davis; Jeroen Essers; Mickey C-T Hu; Roland Kanaar; Yaniv lerenthal; Yosef Shiloh
Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks.
Cell cycle (Georgetown, Tex.) 2011;10(24):4300-10.
2011: Ronit Galron; Ralph Gruber; Michal Kirshner; Veronica Lifshitz; Haizhen Lu; Yosef Shiloh; Zhao-Qi Wang; Natali Ziv; Ari Barzilai; Dan Frenkel
Astrocyte dysfunction associated with cerebellar attrition in a Nijmegen breakage syndrome animal model.
Journal of molecular neuroscience : MN 2011;45(2):202-11.
2011: Yosef Shiloh; Efrat Shema; Lilach Moyal; Moshe Oren
RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response.
FEBS letters 2011;585(18):2795-802.
2011: Dorit Raz-Prag; Niva Segev-Amzaleg; Yosef Shiloh; Arieh S Solomon; Ari Barzilai; Ronit Galron; Dan Frenkel
A role for vascular deficiency in retinal pathology in a mouse model of ataxia-telangiectasia.
The American journal of pathology 2011;179(3):1533-41.
2011: Sharon Rashi-Elkeles; Gideon Rechavi; Ron Shamir; Seagull Shavit; Ninette Amariglio; Ran Elkon; Ana Kupershtein; Yaniv lerenthal; Chaim Linhart; Yosef Shiloh
Transcriptional modulation induced by ionizing radiation: p53 remains a central player.
Molecular oncology 2011;5(4):336-48.
2011: Hava Segal-Raz; Cecilia E Ström; Shih-Ya Wang; Shelly Ziv-Lehrman; Keren Baranes-Bachar; David J Chen; Young Min Chung; Thomas Helleday; Mickey C-T Hu; Yaniv lerenthal; Gilad Mass; Yosef Shiloh
ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair.
EMBO reports 2011;12(7):713-9.
2011: Inbal Dar; Galit Yosha; Ronen Elfassy; Ronit Galron; Zhao-Qi Wang; Yosef Shiloh; Ari Barzilai
Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum.
The Journal of biological chemistry 2011;286(17):15361-76.
2011: Lilach Moyal; Yaniv lerenthal; Mali Gana-Weisz; Gilad Mass; Sairei So; Shih-Ya Wang; Berina Eppink; Young Min Chung; Gil Shalev; Efrat Shema; Dganit Shkedy; Nechama I Smorodinsky; Nicole van Vliet; Bernhard Kuster; Matthias Mann; Aaron Ciechanover; Jochen Dahm-Daphi; Roland Kanaar; Mickey C-T Hu; David J Chen; Moshe Oren; Yosef Shiloh
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks.
Molecular cell 2011;41(5):529-42.
2011: Maayan Salton; Marie-Laure Yaspo; Tatiana Borodina; Aleksey Davydov; Ran Elkon; Eran Halperin; Yosef Shiloh
Matrin 3 binds and stabilizes mRNA.
PloS one 2011;6(8):e23882.
2011: Arnon Paz; Zippora Brownstein; Yaara Ber; Shani Bialik; Eyal David; Dorit Sagir; Igor Ulitsky; Ran Elkon; Adi Kimchi; Karen B Avraham; Yosef Shiloh; Ron Shamir
SPIKE: a database of highly curated human signaling pathways.
Nucleic acids research 2011;39(Database issue):D793-9.
2010: Maayan Salton; Yaniv lerenthal; Shih-Ya Wang; David J Chen; Yosef Shiloh
Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response.
Cell cycle (Georgetown, Tex.) 2010;9(8):1568-76.
2010: Aart G Jochemsen; Yosef Shiloh
USP10: friend and foe.
Cell 2010;140(3):308-10.
2010: Igor Ulitsky; Adi Maron-Katz; Seagull Shavit; Dorit Sagir; Chaim Linhart; Ran Elkon; Amos Tanay; Roded Sharan; Yosef Shiloh; Ron Shamir
Expander: from expression microarrays to networks and functions.
Nature protocols 2010;5(2):303-22.
2010: Ariel Bensimon; Alexander Schmidt; Yael Ziv; Ran Elkon; Shih-Ya Wang; David J Chen; Ruedi Aebersold; Yosef Shiloh
ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage.
Science signaling 2010;3(151):rs3.
2009: Dominic Winter; Joerg Seidler; Shelly Ziv-Lehrman; Yosef Shiloh; Wolf D Lehmann
Simultaneous identification and quantification of proteins by differential (16)O/(18)O labeling and UPLC-MS/MS applied to mouse cerebellar phosphoproteome following irradiation.
Anticancer research 2009;29(12):4949-58.
2009: Koby Baranes; Dorit Raz-Prag; Anat Nitzan; Ronit Galron; Ruth Ashery-Padan; Ygal Rotenstreich; Yaniv Assaf; Yosef Shiloh; Zhao-Qi Wang; Ari Barzilai; Arieh S Solomon
Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system.
Experimental neurology 2009;218(1):24-32.
2009: Michal Kirshner; Moran Rathavs; Anat Nizan; Jeroen Essers; Roland Kanaar; Yosef Shiloh; Ari Barzilai
Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair.
DNA repair 2009;8(2):253-61.
2009: Yosef Shiloh
FBXO31: a new player in the ever-expanding DNA damage response orchestra.
Science signaling 2009;2(96):pe73.
2009: Dominic Winter; Joerg Seidler; Yael Ziv; Yosef Shiloh; Wolf D Lehmann
Citrate boosts the performance of phosphopeptide analysis by UPLC-ESI-MS/MS.
Journal of proteome research 2009;8(1):418-24.
2008: Efrat Shema; Itay Tirosh; Yael Aylon; Jing Huang; Chaoyang Ye; Neta Moskovits; Nina Raver-Shapira; Neri Minsky; Judith Pirngruber; Gabi Tarcic; Pavla Hublarova; Lilach Moyal; Mali Gana-Weisz; Yosef Shiloh; Yosef Yarden; Steven A Johnsen; Borivoj Vojtesek; Shelley L Berger; Moshe Oren
The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.
Genes & development 2008;22(19):2664-76.
2008: Wen-Hsing Cheng; Diana Muftic; Meltem Muftuoglu; Lale Dawut; Christa Morris; Thomas Helleday; Yosef Shiloh; Vilhelm A Bohr
WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks.
Molecular biology of the cell 2008;19(9):3923-33.
2008: ALI GOODARZI; Angela T Noon; Dorothee Deckbar; Yael Ziv; Yosef Shiloh; Markus Löbrich; Penny A Jeggo
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.
Molecular cell 2008;31(2):167-77.
2008: Ari Barzilai; Sharon Biton; Yosef Shiloh
The role of the DNA damage response in neuronal development, organization and maintenance.
DNA repair 2008;7(7):1010-27.
2008: Sharon Biton; Ari Barzilai; Yosef Shiloh
The neurological phenotype of ataxia-telangiectasia: solving a persistent puzzle.
DNA repair 2008;7(7):1028-38.
2008: Ran Elkon; Rita Vesterman; Nira Amit; Igor Ulitsky; Idan Zohar; Mali Weisz; Gilad Mass; Nir Orlev; Giora Sternberg; Ran Blekhman; Jackie Assa; Yosef Shiloh; Ron Shamir
SPIKE--a database, visualization and analysis tool of cellular signaling pathways.
BMC bioinformatics 2008;9():110.
2008: Yaniv Assaf; Ronit Galron; Itai Shapira; Anat Nitzan; Tamar Blumenfeld-Katzir; Arieh S Solomon; Vered Holdengreber; Zhao-Qi Wang; Yosef Shiloh; Ari Barzilai
MRI evidence of white matter damage in a mouse model of Nijmegen breakage syndrome.
Experimental neurology 2008;209(1):181-91.
2007: Neora Alterman; Aviva Fattal-Valevski; Lilach Moyal; Thomas O Crawford; Howard M Lederman; Yehiel Ziv; Yosef Shiloh
Ataxia-telangiectasia: mild neurological presentation despite null ATM mutation and severe cellular phenotype.
American journal of medical genetics. Part A 2007;143A(16):1827-34.
2007: Shuhei Matsuoka; Bryan A Ballif; Agata Smogorzewska; E Robert McDonald; Kristen E Hurov; Ji Luo; Corey E Bakalarski; Zhenming Zhao; Nicole Solimini; Yaniv lerenthal; Yosef Shiloh; Steven P Gygi; Stephen J Elledge
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Science (New York, N.Y.) 2007;316(5828):1160-6.
2007: Michael Blank; Yosef Shiloh
Programs for cell death: apoptosis is only one way to go.
Cell cycle (Georgetown, Tex.) 2007;6(6):686-95.
2007: Benjamin P C Chen; Naoya Uematsu; Junya Kobayashi; Yaniv lerenthal; Andrea Krempler; Hirohiko Yajima; Markus Löbrich; Yosef Shiloh; David J Chen
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.
The Journal of biological chemistry 2007;282(9):6582-7.
2007: Sharon Biton; Michal Gropp; Pavel Itsykson; Yaron Pereg; Leonid Mittelman; Karl Johe; Benjamin E Reubinoff; Yosef Shiloh
ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells.
DNA repair 2007;6(1):128-34.
2007: Ran Elkon; Chaim Linhart; Yonit Halperin; Yosef Shiloh; Ron Shamir
Functional genomic delineation of TLR-induced transcriptional networks.
BMC genomics 2007;8():394.
2006: Yaron Pereg; Suzanne Lam; Amina Teunisse; Sharon Biton; Erik Meulmeester; Leonid Mittelman; Giacomo Buscemi; Koji Okamoto; Yoichi Taya; Yosef Shiloh; Aart G Jochemsen
Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.
Molecular and cellular biology 2006;26(18):6819-31.
2006: Yehiel Ziv; Dana Bielopolski; Yaron Galanty; Claudia Lukas; Yoichi Taya; David C Schultz; Jiri Lukas; Simon Bekker-Jensen; Jiri Bartek; Yosef Shiloh
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.
Nature cell biology 2006;8(8):870-6.
2006: Inbal Dar; Sharon Biton; Yosef Shiloh; Ari Barzilai
Analysis of the ataxia telangiectasia mutated-mediated DNA damage response in murine cerebellar neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(29):7767-74.
2006: Michael Blank; Yaniv lerenthal; Leonid Mittelman; Yosef Shiloh
Condensin I recruitment and uneven chromatin condensation precede mitotic cell death in response to DNA damage.
The Journal of cell biology 2006;174(2):195-206.
2006: Yosef Shiloh
The ATM-mediated DNA-damage response: taking shape.
Trends in biochemical sciences 2006;31(7):402-10.
2006: Sharon Biton; Inbal Dar; Leonid Mittelman; Yaron Pereg; Ari Barzilai; Yosef Shiloh
Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells.
The Journal of biological chemistry 2006;281(25):17482-91.
2006: Sharon Rashi-Elkeles; Ran Elkon; Nir Weizman; Chaim Linhart; Ninette Amariglio; G Sternberg; Gideon Rechavi; Ari Barzilai; Ron Shamir; Yosef Shiloh
Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue.
Oncogene 2006;25(10):1584-92.
2005: Chaim Linhart; Ran Elkon; Yosef Shiloh; Ron Shamir
Deciphering transcriptional regulatory elements that encode specific cell cycle phasing by comparative genomics analysis.
Cell cycle (Georgetown, Tex.) 2005;4(12):1788-97.
2005: Koji Okamoto; Kenji Kashima; Yaron Pereg; Michiko Ishida; Satomi Yamazaki; Ayumi Nota; Amina Teunisse; Domenico Migliorini; Issay Kitabayashi; Jean-Christophe Marine; Carol Prives; Yosef Shiloh; Aart G Jochemsen; Yoichi Taya
DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.
Molecular and cellular biology 2005;25(21):9608-20.
2005: Shelly Ziv; Ori Brenner; Ninette Amariglio; Nechama I Smorodinsky; Ronit Galron; Danaise V Carrion; Weijia Zhang; Girdhar G Sharma; Raj K Pandita; Manjula Agarwal; Ran Elkon; Nirit Katzin; Irit Bar-Am; Tej K Pandita; Raju Kucherlapati; Gideon Rechavi; Yosef Shiloh; Ari Barzilai
Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.
Human molecular genetics 2005;14(19):2929-43.
2005: Erik Meulmeester; Yaron Pereg; Yosef Shiloh; Aart G Jochemsen
ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation.
Cell cycle (Georgetown, Tex.) 2005;4(9):1166-70.
2005: Yaron Pereg; Dganit Shkedy; Petra de Graaf; Erik Meulmeester; Marina Edelson-Averbukh; Mogjiborahman Salek; Sharon Biton; Amina Teunisse; Wolf D Lehmann; Aart G Jochemsen; Yosef Shiloh
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(14):5056-61.
2005: Ron Shamir; Adi Maron-Katz; Amos Tanay; Chaim Linhart; Israel Steinfeld; Roded Sharan; Yosef Shiloh; Ran Elkon
EXPANDER--an integrative program suite for microarray data analysis.
BMC bioinformatics 2005;6():232.
2005: Ran Elkon; Sharon Rashi-Elkeles; Yaniv lerenthal; Chaim Linhart; Tamar Tenne; Ninette Amariglio; Gideon Rechavi; Ron Shamir; Yosef Shiloh
Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis.
Genome biology 2005;6(5):R43.
2004: Yosef Shiloh; Alan Lehmann
Maintaining integrity.
Nature cell biology 2004;6(10):923-8.
2004: Yosef Shiloh; Yair Andegeko; Ilan Tsarfaty
In search of drug treatment for genetic defects in the DNA damage response: the example of ataxia-telangiectasia.
Seminars in cancer biology 2004;14(4):295-305.
2004: Nir Orlev; Ron Shamir; Yosef Shiloh
PIVOT: protein interacions visualizatiOn tool.
Bioinformatics (Oxford, England) 2004;20(3):424-5.
2004: Ran Elkon; Karen I Zeller; Chaim Linhart; Chi Dang; Ron Shamir; Yosef Shiloh
In silico identification of transcriptional regulators associated with c-Myc.
Nucleic acids research 2004;32(17):4955-61.
2003: Tamar Uziel; Yaniv lerenthal; Lilach Moyal; Yair Andegeko; Leonid Mittelman; Yosef Shiloh
Requirement of the MRN complex for ATM activation by DNA damage.
The EMBO journal 2003;22(20):5612-21.
2003: Ran Elkon; Chaim Linhart; Roded Sharan; Ron Shamir; Yosef Shiloh
Genome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells.
Genome research 2003;13(5):773-80.
2003: Yosef Shiloh
ATM: ready, set, go.
Cell cycle (Georgetown, Tex.) 2003;2(2):116-7.
2003: Yosef Shiloh
ATM and related protein kinases: safeguarding genome integrity.
Nature reviews. Cancer 2003;3(3):155-68.
2003: Nir Weizman; Yosef Shiloh; Ari Barzilai
Contribution of the Atm protein to maintaining cellular homeostasis evidenced by continuous activation of the AP-1 pathway in Atm-deficient brains.
The Journal of biological chemistry 2003;278(9):6741-7.
2002: Allen Taylor; Fu Shang; Thomas Nowell; Yaron Galanty; Yosef Shiloh
Ubiquitination capabilities in response to neocarzinostatin and H(2)O(2) stress in cell lines from patients with ataxia-telangiectasia.
Oncogene 2002;21(28):4363-73.
2002: Anat Bar-Shira; Sharon Rashi-Elkeles; Liat Zlochover; Lilach Moyal; Nechama I Smorodinsky; Rony Seger; Yosef Shiloh
ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damage.
Oncogene 2002;21(5):849-55.
2002: Ari Barzilai; Galit Rotman; Yosef Shiloh
ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage.
DNA repair 2002;1(1):3-25.
2002: Naftali Stern; Ayala Hochman; Naty Zemach; Nir Weizman; Ilan Hammel; Yosef Shiloh; Galit Rotman; Ari Barzilai
Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice.
The Journal of biological chemistry 2002;277(1):602-8.
2001: Yair Andegeko; Lilach Moyal; Leonid Mittelman; Ilan Tsarfaty; Yosef Shiloh; Galit Rotman
Nuclear retention of ATM at sites of DNA double strand breaks.
The Journal of biological chemistry 2001;276(41):38224-30.
2001: Valentine M Macaulay; Amanda J Salisbury; Erin A Bohula; Martin P Playford; Nechama I Smorodinsky; Yosef Shiloh
Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase.
Oncogene 2001;20(30):4029-40.
2001: Kevin Spring; S Cross; C Li; Dianne Watters; L Ben-Senior; P Waring; F Ahangari; S L Lu; Philip Chen; Ihor Misko; C Paterson; G Kay; Nechama I Smorodinsky; Yosef Shiloh; Martin F Lavin
Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype.
Cancer research 2001;61(11):4561-8.
2001: Ruth Maya; Moshe Balass; S T Kim; Dganit Shkedy; Juan Fernando Martinez Leal; Ohad Shifman; Miri Moas; T Buschmann; Ze'ev Ronai; Yosef Shiloh; M B Kastan; E Katzir; Moshe Oren
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
Genes & development 2001;15(9):1067-77.
2001: Yakov Peter; Galit Rotman; Joseph Lotem; Ari Elson; Yosef Shiloh; Yoram Groner
Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice.
The EMBO journal 2001;20(7):1538-46.
2001: T Buschmann; Olga Potapova; Anat Bar-Shira; Vladimir N Ivanov; Serge Y Fuchs; Scott Henderson; VA Fried; T Minamoto; Dania Alarcon-Vargas; Matthew R Pincus; William A Gaarde; Nikki J Holbrook; Yosef Shiloh; Ze'ev Ronai
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.
Molecular and cellular biology 2001;21(8):2743-54.
2001: N Li; S Banin; H Ouyang; Gloria C Li; G Courtois; Yosef Shiloh; Michael Karin; Galit Rotman
ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks.
The Journal of biological chemistry 2001;276(12):8898-903.
2001: A Kamsler; Dorah Daily; Ayala Hochman; Naftali Stern; Yosef Shiloh; Galit Rotman; Ari Barzilai
Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice.
Cancer research 2001;61(5):1849-54.
2001: Magtouf Gatei; Dganit Shkedy; Kum Kum Khanna; Tamar Uziel; Yosef Shiloh; Tej K Pandita; Martin F Lavin; Galit Rotman
Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid.
Oncogene 2001;20(3):289-94.
2001: Yosef Shiloh; Michael B Kastan
ATM: genome stability, neuronal development, and cancer cross paths.
Advances in cancer research 2001;83():209-54.
2000: S Matsuoka; Galit Rotman; A Ogawa; Yosef Shiloh; Katsuyuki Tamai; Stephen J Elledge
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10389-94.
2000: Yosef Shiloh
ATM: sounding the double-strand break alarm.
Cold Spring Harbor symposia on quantitative biology 2000;65():527-33.
2000: Yehiel Ziv; S Banin; D S Lim; Shilpy Sharma; Michael B Kastan; Yosef Shiloh
Expression and assay of recombinant ATM.
Methods in molecular biology (Clifton, N.J.) 2000;99():99-108.
1999: R Khosravi; Ruth Maya; Tanya Gottlieb; Moshe Oren; Yosef Shiloh; Dganit Shkedy
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):14973-7.
1999: Galit Rotman; Yosef Shiloh
ATM: a mediator of multiple responses to genotoxic stress.
Oncogene 1999;18(45):6135-44.
1999: Sharon Hassin-Baer; Anat Bar-Shira; Susan Gilad; Yaron Galanty; R Khosravi; Alexander Lossos; Nir Giladi; R Weitz; Bruria Ben-Zeev; Y Goldhammer; Yosef Shiloh
Absence of mutations in ATM, the gene responsible for ataxia telangiectasia in patients with cerebellar ataxia.
Journal of neurology 1999;246(8):716-9.
1999: N Sandoval; Matthias Platzer; André Rosenthal; Thilo Dörk; Regina Bendix; Britta Skawran; Manfred Stuhrmann; Rolf-Dieter Wegner; Karl Sperling; S Banin; Yosef Shiloh; A Baumer; U Bernthaler; H Sennefelder; M Brohm; Bernhard H F Weber; Detlev Schindler
Characterization of ATM gene mutations in 66 ataxia telangiectasia families.
Human molecular genetics 1999;8(1):69-79.
1998: Nelson Rhodes; T D'Souza; C D Foster; Yehiel Ziv; D G Kirsch; Yosef Shiloh; Michael B Kastan; Peter H Reinhart; Tona M Gilmer
Defective potassium currents in ataxia telangiectasia fibroblasts.
Genes & development 1998;12(23):3686-92.
1998: Yosef Shiloh
Ataxia-telangiectasia, ATM and genomic stability: maintaining a delicate balance. Two international workshops on ataxia-telangiectasia, related disorders and the ATM protein.
Biochimica et biophysica acta 1998;1378(2):R11-8.
1998: Raya Eilam; Yakov Peter; Ari Elson; Galit Rotman; Yosef Shiloh; Yoram Groner; Menahem Segal
Selective loss of dopaminergic nigro-striatal neurons in brains of Atm-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12653-6.
1998: S Banin; Lilach Moyal; S Shieh; Yoichi Taya; C W Anderson; Luciana Chessa; Nechama I Smorodinsky; C Prives; Yuval Reiss; Yosef Shiloh; Yehiel Ziv
Enhanced phosphorylation of p53 by ATM in response to DNA damage.
Science (New York, N.Y.) 1998;281(5383):1674-7.
1998: Dae-Sik Lim; D G Kirsch; Shilpy Sharma; JIN HYUN AHN; Yehiel Ziv; L S Newman; R B Darnell; Yosef Shiloh; Michael B Kastan
ATM binds to beta-adaptin in cytoplasmic vesicles.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10146-51.
1998: Susan Gilad; Luciana Chessa; R Khosravi; P Russell; Yaron Galanty; Maria Piane; R A Gatti; Timothy Jorgensen; Yosef Shiloh; Anat Bar-Shira
Genotype-phenotype relationships in ataxia-telangiectasia and variants.
American journal of human genetics 1998;62(3):551-61.
1998: Toshiyuki Fukao; XQ Song; T Yoshida; H Tashita; Hideo Kaneko; Takahide Teramoto; Ryosuke Inoue; K Katamura; M Mayumi; M Hiratani; N Taniguchi; J Arai; H Wakiguchi; Anat Bar-Shira; Yosef Shiloh; Naomi Kondo
Ataxia-telangiectasia in the Japanese population: identification of R1917X, W2491R, R2909G, IVS33+2T-->A, and 7883del5, the latter two being relatively common mutations.
Human mutation 1998;12(5):338-43.
1998: Galit Rotman; Yosef Shiloh
ATM: from gene to function.
Human molecular genetics 1998;7(10):1555-63.
1998: Yosef Shiloh; Anat Bar-Shira; Yaron Galanty; Yehiel Ziv
Cloning and expression of large mammalian cDNAs: lessons from ATM.
Genetic engineering 1998;20():239-48.
1998: Toshiyuki Fukao; H Tashita; Takahide Teramoto; Ryosuke Inoue; Hideo Kaneko; K Komiyama; Anat Bar-Shira; Susan Gilad; Yosef Shiloh; M Nishimura; Naomi Kondo
Novel exonic mutation (5319 G to A) resulting in two aberrantly spliced transcripts of the ATM gene in a Japanese patient with ataxia-telangiectasia.
Human mutation 1998;Suppl 1():S223-5.
1998: Susan Gilad; R Khosravi; R Harnik; Yehiel Ziv; Dganit Shkedy; Yaron Galanty; Moshe Frydman; J Levi; Ozden Sanal; Luciana Chessa; D Smeets; Yosef Shiloh; Anat Bar-Shira
Identification of ATM mutations using extended RT-PCR and restriction endonuclease fingerprinting, and elucidation of the repertoire of A-T mutations in Israel.
Human mutation 1998;11(1):69-75.
1997: Galit Rotman; Yosef Shiloh
Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress?
BioEssays : news and reviews in molecular, cellular and developmental biology 1997;19(10):911-7.
1997: Yehiel Ziv; Anat Bar-Shira; I Pecker; P Russell; Timothy Jorgensen; Ilan Tsarfaty; Yosef Shiloh
Recombinant ATM protein complements the cellular A-T phenotype.
Oncogene 1997;15(2):159-67.
1997: Matthias Platzer; Galit Rotman; D Bauer; Tamar Uziel; Kinneret Savitsky; Anat Bar-Shira; Susan Gilad; Yosef Shiloh; André Rosenthal
Ataxia-telangiectasia locus: sequence analysis of 184 kb of human genomic DNA containing the entire ATM gene.
Genome research 1997;7(6):592-605.
1997: T Shafman; Kum Kum Khanna; Padmini Kedar; Kevin Spring; Sergei Kozlov; T Yen; Karen Hobson; Magtouf Gatei; N Zhang; Dianne Watters; M Egerton; Yosef Shiloh; S Kharbanda; Donald Kufe; Martin F Lavin
Interaction between ATM protein and c-Abl in response to DNA damage.
Nature 1997;387(6632):520-3.
1997: Kinneret Savitsky; Matthias Platzer; Tamar Uziel; Susan Gilad; A Sartiel; André Rosenthal; Orna Elroy-Stein; Yosef Shiloh; Galit Rotman
Ataxia-telangiectasia: structural diversity of untranslated sequences suggests complex post-transcriptional regulation of ATM gene expression.
Nucleic acids research 1997;25(9):1678-84.
1997: Kum Kum Khanna; J Yan; Dianne Watters; Karen Hobson; Heather Beamish; Kevin Spring; Yosef Shiloh; Richard A Gatti; Martin F Lavin
Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cells.
The Journal of biological chemistry 1997;272(14):9489-95.
1997: KD Brown; Yehiel Ziv; S N Sadanandan; Luciana Chessa; Francis S Collins; Yosef Shiloh; Danilo A Tagle
The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1840-5.
1997: Yosef Shiloh
Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart.
Annual review of genetics 1997;31():635-62.
1997: Galit Rotman; Yosef Shiloh
The ATM gene and protein: possible roles in genome surveillance, checkpoint controls and cellular defence against oxidative stress.
Cancer surveys 1997;29():285-304.
1997: Martin F Lavin; Yosef Shiloh
The genetic defect in ataxia-telangiectasia.
Annual review of immunology 1997;15():177-202.
1996: Susan Gilad; Anat Bar-Shira; R Harnik; Dganit Shkedy; Yehiel Ziv; R Khosravi; K Brown; L Vanagaite; G Xu; Moshe Frydman; M F Lavin; D Hill; Danilo A Tagle; Yosef Shiloh
Ataxia-telangiectasia: founder effect among north African Jews.
Human molecular genetics 1996;5(12):2033-7.
1996: H Beamish; Richard Williams; Philip Chen; Kum Kum Khanna; Karen Hobson; Dianne Watters; Yosef Shiloh; Martin Lavin
Rapamycin resistance in ataxia-telangiectasia.
Oncogene 1996;13(5):963-70.
1996: Yosef Shiloh; Galit Rotman
Ataxia-telangiectasia and the ATM gene: linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpoints.
Journal of clinical immunology 1996;16(5):254-60.
1996: Carrolee Barlow; Shinji Hirotsune; Richard Paylor; Marek Liyanage; Michael Eckhaus; Francis S Collins; Yosef Shiloh; Jacqueline N Crawley; Thomas Ried; Danilo A Tagle; Anthony Wynshaw-Boris
Atm-deficient mice: a paradigm of ataxia telangiectasia.
Cell 1996;86(1):159-71.
1996: I Pecker; Karen B Avraham; D J Gilbert; Kinneret Savitsky; Galit Rotman; R Harnik; T Fukao; E Schröck; Shinji Hirotsune; Danilo A Tagle; Francis S Collins; Anthony Wynshaw-Boris; Thomas Ried; N G Copeland; N A Jenkins; Yosef Shiloh; Yehiel Ziv
Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene.
Genomics 1996;35(1):39-45.
1996: Milhan Telatar; Zhijun Wang; Nitin Udar; T Liang; E Bernatowska-Matuszkiewicz; M Lavin; Yosef Shiloh; Patrick Concannon; R A Good; Richard A Gatti
Ataxia-telangiectasia: mutations in ATM cDNA detected by protein-truncation screening.
American journal of human genetics 1996;59(1):40-4.
1996: Tamar Uziel; Kinneret Savitsky; Matthias Platzer; Yehiel Ziv; T Helbitz; M Nehls; Thomas Boehm; André Rosenthal; Yosef Shiloh; Galit Rotman
Genomic Organization of the ATM gene.
Genomics 1996;33(2):317-20.
1996: Kinneret Savitsky; Yehiel Ziv; Anat Bar-Shira; Susan Gilad; Danilo A Tagle; S Smith; Tamar Uziel; S Sfez; J Nahmias; A Sartiel; R L Eddy; T B Shows; Francis S Collins; Yosef Shiloh; Galit Rotman
A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.
Genomics 1996;33(2):199-206.
1996: Susan Gilad; R Khosravi; Dganit Shkedy; Tamar Uziel; Yehiel Ziv; Kinneret Savitsky; Galit Rotman; S Smith; Luciana Chessa; Timothy Jorgensen; R Harnik; Moshe Frydman; Ozden Sanal; S Portnoi; Z Goldwicz; Nicolaas G J Jaspers; Richard A Gatti; G Lenoir; M F Lavin; K Tatsumi; Rolf-Dieter Wegner; Yosef Shiloh; Anat Bar-Shira
Predominance of null mutations in ataxia-telangiectasia.
Human molecular genetics 1996;5(4):433-9.
1995: Kinneret Savitsky; S Sfez; Danilo A Tagle; Yehiel Ziv; A Sartiel; Francis S Collins; Yosef Shiloh; Galit Rotman
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species.
Human molecular genetics 1995;4(11):2025-32.
1995: Martin F Lavin; Kum Kum Khanna; H Beamish; Kevin Spring; Dianne Watters; Yosef Shiloh
Relationship of the ataxia-telangiectasia protein ATM to phosphoinositide 3-kinase.
Trends in biochemical sciences 1995;20(10):382-3.
1995: Kinneret Savitsky; Anat Bar-Shira; Susan Gilad; Galit Rotman; Yehiel Ziv; L Vanagaite; Danilo A Tagle; S Smith; Tamar Uziel; S Sfez; Malka Ashkenazi; I Pecker; Moshe Frydman; R Harnik; S R Patanjali; A Simmons; GA Clines; A Sartiel; Richard A Gatti; Luciana Chessa; Ozden Sanal; M F Lavin; Nicolaas G J Jaspers; A M Taylor; C F Arlett; T Miki; S M Weissman; Michael Lovett; Francis S Collins; Yosef Shiloh
A single ataxia telangiectasia gene with a product similar to PI-3 kinase.
Science (New York, N.Y.) 1995;268(5218):1749-53.
1995: L Vanagaite; MR James; Galit Rotman; Kinneret Savitsky; Anat Bar-Shira; Susan Gilad; Yehiel Ziv; V Uchenik; A Sartiel; Francis S Collins; Val C Sheffield; C W Richard; J Weissenbach; Yosef Shiloh
A high-density microsatellite map of the ataxia-telangiectasia locus.
Human genetics 1995;95(4):451-4.
1995: Galit Rotman; L Vanagaite; Francis S Collins; Yosef Shiloh
Rapid identification of polymorphic CA-repeats in YAC clones.
Molecular biotechnology 1995;3(2):85-92.
1995: Yehiel Ziv; Anat Bar-Shira; Timothy Jorgensen; P S Russell; A Sartiel; T B Shows; R L Eddy; M Buchwald; R Legerski; R T Schimke; Yosef Shiloh
Human cDNA clones that modify radiomimetic sensitivity of ataxia-telangiectasia (group A) cells.
Somatic cell and molecular genetics 1995;21(2):99-111.
1995: Yosef Shiloh
Ataxia-telangiectasia: closer to unraveling the mystery.
European journal of human genetics : EJHG 1995;3(2):116-38.
1994: Galit Rotman; K Savitski; L Vanagaite; Anat Bar-Shira; Yehiel Ziv; Susan Gilad; V Uchenik; S Smith; Yosef Shiloh
Physical and genetic mapping at the ATA/ATC locus on chromosome 11q22-23.
International journal of radiation biology 1994;66(6 Suppl):S63-6.
1994: Richard A Gatti; Ethan M Lange; Galit Rotman; X Chen; Nancy Uhrhammer; T Liang; S Chiplunkar; L Yang; Nitin Udar; S Dandekar; S Sheikhavandi; Zhijun Wang; H M Yang; J Polikow; M Elashoff; M Teletar; Ozden Sanal; Luciana Chessa; Carmel M McConville; M Taylor; Yosef Shiloh; Oscar Porras; A L Borresen; Rolf-Dieter Wegner; C Curry; S Gerken; K Lange; Patrick Concannon
Genetic haplotyping of ataxia-telangiectasia families localizes the major gene to an approximately 850 kb region on chromosome 11q23.1.
International journal of radiation biology 1994;66(6 Suppl):S57-62.
1994: A Malcolm R Taylor; Carmel M McConville; Galit Rotman; Yosef Shiloh; Philip J Byrd
A haplotype common to intermediate radiosensitivity variants of ataxia-telangiectasia in the UK.
International journal of radiation biology 1994;66(6 Suppl):S35-41.
1994: Galit Rotman; Kinneret Savitsky; Yehiel Ziv; C G Cole; Michael J Higgins; I Bar-Am; Carl Bruder; Anat Bar-Shira; L Vanagaite; S Qin; J Zhang; N J Nowak; Settara C Chandrasekharappa; H Lehrach; Lydia Avivi; T B Shows; Francis S Collins; David R Bentley; Yosef Shiloh
A YAC contig spanning the ataxia-telangiectasia locus (groups A and C) at 11q22-q23.
Genomics 1994;24(2):234-42.
1994: Galit Rotman; L Vanagaite; Francis S Collins; Yosef Shiloh
Three dinucleotide repeat polymorphisms at the ataxia-telangiectasia locus.
Human molecular genetics 1994;3(11):2079.
1994: L Vanagaite; Kinneret Savitsky; Galit Rotman; Yehiel Ziv; S C Gerken; Raymond White; J Weissenbach; G Gillett; F J Benham; C W Richard; MR James; Francis S Collins; Yosef Shiloh
Physical localization of microsatellite markers at the ataxia-telangiectasia locus at 11q22-q23.
Genomics 1994;22(1):231-3.
1994: H J Ambrose; Philip J Byrd; Carmel M McConville; Paul Roy Cooper; Tatjana Stankovic; J H Riley; Yosef Shiloh; J O McNamara; T Fukao; A Malcolm R Taylor
A physical map across chromosome 11q22-q23 containing the major locus for ataxia telangiectasia.
Genomics 1994;21(3):612-9.
1994: S Kleiman; Smadar Avigad; L Vanagaite; A Shmuelevitz; Michael David; R C Eisensmith; N Brand; G Schwartz; F Rey; A Munnich; S L Woo; Yosef Shiloh
Origins of hyperphenylalaninemia in Israel.
European journal of human genetics : EJHG 1994;2(1):24-34.
1993: Carmel M McConville; Philip J Byrd; H J Ambrose; Tatjana Stankovic; Yehiel Ziv; Anat Bar-Shira; L Vanagaite; Galit Rotman; Yosef Shiloh; G T Gillett
Paired STSs amplified from radiation hybrids, and from associated YACs, identify highly polymorphic loci flanking the ataxia telangiectasia locus on chromosome 11q22-23.
Human molecular genetics 1993;2(7):969-74.
1993: S Kleiman; J Li; G Schwartz; R C Eisensmith; S L Woo; Yosef Shiloh
Inactivation of phenylalanine hydroxylase by a missense mutation, R270S, in a Palestinian kinship with phenylketonuria.
Human molecular genetics 1993;2(5):605-6.
1993: S Kleiman; L Vanagaite; J Bernstein; G Schwartz; N Brand; A Elitzur; S L Woo; Yosef Shiloh
Phenylketonuria: variable phenotypic outcomes of the R261Q mutation and maternal PKU in the offspring of a healthy homozygote.
Journal of medical genetics 1993;30(4):284-8.
1993: O Mor; G N Ranzani; Y Ravia; Galit Rotman; M Gutman; A Manor; D Amadori; J Houldsworth; M Hollstein; M Schwab; Yosef Shiloh
DNA amplification in human gastric carcinomas.
Cancer genetics and cytogenetics 1993;65(2):111-4.
1993: M Weinstein; R C Eisensmith; V Abadie; Smadar Avigad; S Lyonnet; G Schwartz; A Munnich; S L Woo; Yosef Shiloh
A missense mutation, S349P, completely inactivates phenylalanine hydroxylase in north African Jews with phenylketonuria.
Human genetics 1993;90(6):645-9.
1992: I Bar-Am; O Mor; Herman Yeger; Yosef Shiloh; Lydia Avivi
Detection of amplified DNA sequences in human tumor cell lines by fluorescence in situ hybridization.
Genes, chromosomes & cancer 1992;4(4):314-20.
1992: Yosef Shiloh; O Mor; A Manor; I Bar-Am; Galit Rotman; J Eubanks; M Gutman; G N Ranzani; J Houldsworth; G Evans
DNA sequences amplified in cancer cells: an interface between tumor biology and human genome analysis.
Mutation research 1992;276(3):329-37.
1992: Yehiel Ziv; Moshe Frydman; Ethan M Lange; N Zelnik; Galit Rotman; C Julier; Nicolaas G J Jaspers; Yaron Dagan; D Abeliovicz; H Dar; Z Borochowitz; M Lathrop; Richard A Gatti; Yosef Shiloh
Ataxia-telangiectasia: linkage analysis in highly inbred Arab and Druze families and differentiation from an ataxia-microcephaly-cataract syndrome.
Human genetics 1992;88(6):619-26.
1992: S Kleiman; G Schwartz; S L Woo; Yosef Shiloh
A 22-bp deletion in the phenylalanine hydroxylase gene causing phenylketonuria in an Arab family.
Human mutation 1992;1(4):344-6.
1992: S Kleiman; J Bernstein; G Schwartz; R C Eisensmith; S L Woo; Yosef Shiloh
A defective splice site at the phenylalanine hydroxylase gene in phenylketonuria and benign hyperphenylalaninemia among Palestinian Arabs.
Human mutation 1992;1(4):340-3.
1991: T Foroud; S Wei; Yehiel Ziv; E Sobel; Ethan M Lange; A Chao; T Goradia; Y Huo; A Tolun; Luciana Chessa; P Charmley; Ozden Sanal; N Salman; C Julier; Patrick Concannon; Carmel M McConville; A Malcolm R Taylor; Yosef Shiloh; S K Lange; Richard A Gatti
Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: linkage analysis of 111 families by an international consortium.
American journal of human genetics 1991;49(6):1263-79.
1991: Smadar Avigad; S Kleiman; M Weinstein; B E Cohen; G Schwartz; S L Woo; Yosef Shiloh
Compound heterozygosity in nonphenylketonuria hyperphenylalanemia: the contribution of mutations for classical phenylketonuria.
American journal of human genetics 1991;49(2):393-9.
1991: Yehiel Ziv; Galit Rotman; Moshe Frydman; J Dagan; T Cohen; T Foroud; Richard A Gatti; Yosef Shiloh
The ATC (ataxia-telangiectasia complementation group C) locus localizes to 11q22-q23.
Genomics 1991;9(2):373-5.
1991: O Mor; Y Messinger; Galit Rotman; I Bar-Am; Y Ravia; R L Eddy; T B Shows; J G Park; A F Gazdar; Yosef Shiloh
Novel DNA sequences at chromosome 10q26 are amplified in human gastric carcinoma cell lines: molecular cloning by competitive DNA reassociation.
Nucleic acids research 1991;19(1):117-23.
1990: Yosef Shiloh; G Litvak; Yehiel Ziv; T Lehner; L Sandkuyl; Minka Hildesheimer; V Buchris; F P Cremers; P Szabo; B N White
Genetic mapping of X-linked albinism-deafness syndrome (ADFN) to Xq26.3-q27.I.
American journal of human genetics 1990;47(1):20-7.
1990: Herman Yeger; O Mor; G Pawlin; C Kaplinsky; Yosef Shiloh
Importance of phenotypic and molecular characterization for identification of a neuroepithelioma tumor cell line, NUB-20.
Cancer research 1990;50(9):2794-802.
1990: Smadar Avigad; B E Cohen; S Bauer; G Schwartz; Moshe Frydman; S L Woo; Y Niny; Yosef Shiloh
A single origin of phenylketonuria in Yemenite Jews.
Nature 1990;344(6262):168-70.
1989: Yosef Shiloh; R Parshad; Moshe Frydman; K K Sanford; S Portnoi; Yehiel Ziv; G M Jones
G2 chromosomal radiosensitivity in families with ataxia-telangiectasia.
Human genetics 1989;84(1):15-8.
1989: Yehiel Ziv; Nicolaas G J Jaspers; S Etkin; tsafi danieli; L Trakhtenbrot; Aliza Amiel; Y Ravia; Yosef Shiloh
Cellular and molecular characteristics of an immortalized ataxia-telangiectasia (group AB) cell line.
Cancer research 1989;49(9):2495-501.
1989: Yehiel Ziv; Aliza Amiel; Nicolaas G J Jaspers; A I Berkel; Yosef Shiloh
Ataxia-telangiectasia: a variant with altered in vitro phenotype of fibroblast cells.
Mutation research 1989;210(2):211-9.