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Yosef Shiloh

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Baranes Koby; Raz-Prag Dorit; Nitzan Anat; Galron Ronit; Ashery-Padan Ruth; Rotenstreich Ygal; Assaf Yaniv; Shiloh Yosef; Wang Zhao-Qi; Barzilai Ari; Solomon Arieh S
Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system.
Kirshner Michal; Rathavs Moran; Nizan Anat; Essers Jeroen; Kanaar Roland; Shiloh Yosef; Barzilai Ari
Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair.
Winter Dominic; Seidler Joerg; Ziv Yael; Shiloh Yosef; Lehmann Wolf D
Citrate boosts the performance of phosphopeptide analysis by UPLC-ESI-MS/MS.

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All Publications

2009: Baranes Koby; Raz-Prag Dorit; Nitzan Anat; Galron Ronit; Ashery-Padan Ruth; Rotenstreich Ygal; Assaf Yaniv; Shiloh Yosef; Wang Zhao-Qi; Barzilai Ari; Solomon Arieh S
Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system.
Experimental neurology 2009;218(1):24-32.
2009: Kirshner Michal; Rathavs Moran; Nizan Anat; Essers Jeroen; Kanaar Roland; Shiloh Yosef; Barzilai Ari
Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair.
DNA repair 2009;8(2):253-61.
2009: Winter Dominic; Seidler Joerg; Ziv Yael; Shiloh Yosef; Lehmann Wolf D
Citrate boosts the performance of phosphopeptide analysis by UPLC-ESI-MS/MS.
Journal of proteome research 2009;8(1):418-24.
2009: Shiloh Yosef
FBXO31: a new player in the ever-expanding DNA damage response orchestra.
Science signaling 2009;2(96):pe73.
2008: Shema Efrat; Tirosh Itay; Aylon Yael; Huang Jing; Ye Chaoyang; Moskovits Neta; Raver-Shapira Nina; Minsky Neri; Pirngruber Judith; Tarcic Gabi; Hublarova Pavla; Moyal Lilach; Gana-Weisz Mali; Shiloh Yosef; Yarden Yossef; Johnsen Steven A; Vojtesek Borivoj; Berger Shelley L; Oren Moshe
The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.
Genes & development 2008;22(19):2664-76.
2008: Cheng Wen-Hsing; Muftic Diana; Muftuoglu Meltem; Dawut Lale; Morris Christa; Helleday Thomas; Shiloh Yosef; Bohr Vilhelm A
WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks.
Molecular biology of the cell 2008;19(9):3923-33.
2008: Goodarzi Aaron A; Noon Angela T; Deckbar Dorothee; Ziv Yael; Shiloh Yosef; Löbrich Markus; Jeggo Penny A
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.
Molecular cell 2008;31(2):167-77.
2008: Barzilai Ari; Biton Sharon; Shiloh Yosef
The role of the DNA damage response in neuronal development, organization and maintenance.
DNA repair 2008;7(7):1010-27.
2008: Biton Sharon; Barzilai Ari; Shiloh Yosef
The neurological phenotype of ataxia-telangiectasia: solving a persistent puzzle.
DNA repair 2008;7(7):1028-38.
2008: Assaf Yaniv; Galron Ronit; Shapira Itai; Nitzan Anat; Blumenfeld-Katzir Tamar; Solomon Arieh S; Holdengreber Vered; Wang Zhao-Qi; Shiloh Yosef; Barzilai Ari
MRI evidence of white matter damage in a mouse model of Nijmegen breakage syndrome.
Experimental neurology 2008;209(1):181-91.
2008: Elkon Ran; Vesterman Rita; Amit Nira; Ulitsky Igor; Zohar Idan; Weisz Mali; Mass Gilad; Orlev Nir; Sternberg Giora; Blekhman Ran; Assa Jackie; Shiloh Yosef; Shamir Ron
SPIKE--a database, visualization and analysis tool of cellular signaling pathways.
BMC bioinformatics 2008;9():110.
2007: Alterman Neora; Fattal-Valevski Aviva; Moyal Lilach; Crawford Thomas O; Lederman Howard M; Ziv Yael; Shiloh Yosef
Ataxia-telangiectasia: mild neurological presentation despite null ATM mutation and severe cellular phenotype.
American journal of medical genetics. Part A 2007;143A(16):1827-34.
2007: Matsuoka Shuhei; Ballif Bryan A; Smogorzewska Agata; McDonald E Robert; Hurov Kristen E; Luo Ji; Bakalarski Corey E; Zhao Zhenming; Solimini Nicole; Lerenthal Yaniv; Shiloh Yosef; Gygi Steven P; Elledge Stephen J
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Science (New York, N.Y.) 2007;316(5828):1160-6.
2007: Blank Michael; Shiloh Yosef
Programs for cell death: apoptosis is only one way to go.
Cell cycle (Georgetown, Tex.) 2007;6(6):686-95.
2007: Chen Benjamin P C; Uematsu Naoya; Kobayashi Junya; Lerenthal Yaniv; Krempler Andrea; Yajima Hirohiko; Löbrich Markus; Shiloh Yosef; Chen David J
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.
The Journal of biological chemistry 2007;282(9):6582-7.
2007: Biton Sharon; Gropp Michal; Itsykson Pavel; Pereg Yaron; Mittelman Leonid; Johe Karl; Reubinoff Benjamin; Shiloh Yosef
ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells.
DNA repair 2007;6(1):128-34.
2007: Elkon Ran; Linhart Chaim; Halperin Yonit; Shiloh Yosef; Shamir Ron
Functional genomic delineation of TLR-induced transcriptional networks.
BMC genomics 2007;8():394.
2006: Pereg Yaron; Lam Suzanne; Teunisse Amina; Biton Sharon; Meulmeester Erik; Mittelman Leonid; Buscemi Giacomo; Okamoto Koji; Taya Yoichi; Shiloh Yosef; Jochemsen Aart G
Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.
Molecular and cellular biology 2006;26(18):6819-31.
2006: Ziv Yael; Bielopolski Dana; Galanty Yaron; Lukas Claudia; Taya Yoichi; Schultz David C; Lukas Jiri; Bekker-Jensen Simon; Bartek Jiri; Shiloh Yosef
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.
Nature cell biology 2006;8(8):870-6.
2006: Dar Inbal; Biton Sharon; Shiloh Yosef; Barzilai Ari
Analysis of the ataxia telangiectasia mutated-mediated DNA damage response in murine cerebellar neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(29):7767-74.
2006: Blank Michael; Lerenthal Yaniv; Mittelman Leonid; Shiloh Yosef
Condensin I recruitment and uneven chromatin condensation precede mitotic cell death in response to DNA damage.
The Journal of cell biology 2006;174(2):195-206.
2006: Shiloh Yosef
The ATM-mediated DNA-damage response: taking shape.
Trends in biochemical sciences 2006;31(7):402-10.
2006: Biton Sharon; Dar Inbal; Mittelman Leonid; Pereg Yaron; Barzilai Ari; Shiloh Yosef
Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells.
The Journal of biological chemistry 2006;281(25):17482-91.
2006: Rashi-Elkeles S; Elkon R; Weizman N; Linhart C; Amariglio N; Sternberg G; Rechavi G; Barzilai A; Shamir R; Shiloh Y
Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue.
Oncogene 2006;25(10):1584-92.
2005: Linhart Chaim; Elkon Ran; Shiloh Yosef; Shamir Ron
Deciphering transcriptional regulatory elements that encode specific cell cycle phasing by comparative genomics analysis.
Cell cycle (Georgetown, Tex.) 2005;4(12):1788-97.
2005: Okamoto Koji; Kashima Kenji; Pereg Yaron; Ishida Michiko; Yamazaki Satomi; Nota Ayumi; Teunisse Amina; Migliorini Domenico; Kitabayashi Issay; Marine Jean-Christophe; Prives Carol; Shiloh Yosef; Jochemsen Aart G; Taya Yoichi
DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.
Molecular and cellular biology 2005;25(21):9608-20.
2005: Ziv Shelly; Brenner Ori; Amariglio Ninette; Smorodinsky Nechama I; Galron Ronit; Carrion Danaise V; Zhang Weijia; Sharma Girdhar G; Pandita Raj K; Agarwal Manjula; Elkon Ran; Katzin Nirit; Bar-Am Irit; Pandita Tej K; Kucherlapati Raju; Rechavi Gideon; Shiloh Yosef; Barzilai Ari
Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.
Human molecular genetics 2005;14(19):2929-43.
2005: Meulmeester Erik; Pereg Yaron; Shiloh Yosef; Jochemsen Aart G
ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation.
Cell cycle (Georgetown, Tex.) 2005;4(9):1166-70.
2005: Pereg Yaron; Shkedy Dganit; de Graaf Petra; Meulmeester Erik; Edelson-Averbukh Marina; Salek Mogjiborahman; Biton Sharon; Teunisse Amina F A S; Lehmann Wolf D; Jochemsen Aart G; Shiloh Yosef
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(14):5056-61.
2005: Shamir Ron; Maron-Katz Adi; Tanay Amos; Linhart Chaim; Steinfeld Israel; Sharan Roded; Shiloh Yosef; Elkon Ran
EXPANDER--an integrative program suite for microarray data analysis.
BMC bioinformatics 2005;6():232.
2005: Elkon Ran; Rashi-Elkeles Sharon; Lerenthal Yaniv; Linhart Chaim; Tenne Tamar; Amariglio Ninette; Rechavi Gideon; Shamir Ron; Shiloh Yosef
Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis.
Genome biology 2005;6(5):R43.
2004: Shiloh Yosef; Lehmann Alan R
Maintaining integrity.
Nature cell biology 2004;6(10):923-8.
2004: Shiloh Yosef; Andegeko Yair; Tsarfaty Ilan
In search of drug treatment for genetic defects in the DNA damage response: the example of ataxia-telangiectasia.
Seminars in cancer biology 2004;14(4):295-305.
2004: Orlev Nir; Shamir Ron; Shiloh Yosef
PIVOT: protein interacions visualizatiOn tool.
Bioinformatics (Oxford, England) 2004;20(3):424-5.
2004: Elkon Ran; Zeller Karen I; Linhart Chaim; Dang Chi V; Shamir Ron; Shiloh Yosef
In silico identification of transcriptional regulators associated with c-Myc.
Nucleic acids research 2004;32(17):4955-61.
2003: Uziel Tamar; Lerenthal Yaniv; Moyal Lilach; Andegeko Yair; Mittelman Leonid; Shiloh Yosef
Requirement of the MRN complex for ATM activation by DNA damage.
The EMBO journal 2003;22(20):5612-21.
2003: Elkon Ran; Linhart Chaim; Sharan Roded; Shamir Ron; Shiloh Yosef
Genome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells.
Genome research 2003;13(5):773-80.
2003: Shiloh Yosef
ATM: ready, set, go.
Cell cycle (Georgetown, Tex.) 2003;2(2):116-7.
2003: Shiloh Yosef
ATM and related protein kinases: safeguarding genome integrity.
Nature reviews. Cancer 2003;3(3):155-68.
2003: Weizman Nir; Shiloh Yosef; Barzilai Ari
Contribution of the Atm protein to maintaining cellular homeostasis evidenced by continuous activation of the AP-1 pathway in Atm-deficient brains.
The Journal of biological chemistry 2003;278(9):6741-7.
2002: Taylor Allen; Shang Fu; Nowell Thomas; Galanty Yaron; Shiloh Yosef
Ubiquitination capabilities in response to neocarzinostatin and H(2)O(2) stress in cell lines from patients with ataxia-telangiectasia.
Oncogene 2002;21(28):4363-73.
2002: Barzilai Ari; Rotman Galit; Shiloh Yosef
ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage.
DNA repair 2002;1(1):3-25.
2002: Bar-Shira Anat; Rashi-Elkeles Sharon; Zlochover Liat; Moyal Lilach; Smorodinsky Nechama I; Seger Rony; Shiloh Yosef
ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damage.
Oncogene 2002;21(5):849-55.
2002: Stern Nora; Hochman Ayala; Zemach Naty; Weizman Nir; Hammel Ilan; Shiloh Yosef; Rotman Galit; Barzilai Ari
Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice.
The Journal of biological chemistry 2002;277(1):602-8.
2001: Andegeko Y; Moyal L; Mittelman L; Tsarfaty I; Shiloh Y; Rotman G
Nuclear retention of ATM at sites of DNA double strand breaks.
The Journal of biological chemistry 2001;276(41):38224-30.
2001: Macaulay V M; Salisbury A J; Bohula E A; Playford M P; Smorodinsky N I; Shiloh Y
Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase.
Oncogene 2001;20(30):4029-40.
2001: Spring K; Cross S; Li C; Watters D; Ben-Senior L; Waring P; Ahangari F; Lu S L; Chen P; Misko I; Paterson C; Kay G; Smorodinsky N I; Shiloh Y; Lavin M F
Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype.
Cancer research 2001;61(11):4561-8.
2001: Maya R; Balass M; Kim S T; Shkedy D; Leal J F; Shifman O; Moas M; Buschmann T; Ronai Z; Shiloh Y; Kastan M B; Katzir E; Oren M
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
Genes & development 2001;15(9):1067-77.
2001: Peter Y; Rotman G; Lotem J; Elson A; Shiloh Y; Groner Y
Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice.
The EMBO journal 2001;20(7):1538-46.
2001: Buschmann T; Potapova O; Bar-Shira A; Ivanov V N; Fuchs S Y; Henderson S; Fried V A; Minamoto T; Alarcon-Vargas D; Pincus M R; Gaarde W A; Holbrook N J; Shiloh Y; Ronai Z
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.
Molecular and cellular biology 2001;21(8):2743-54.
2001: Kamsler A; Daily D; Hochman A; Stern N; Shiloh Y; Rotman G; Barzilai A
Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice.
Cancer research 2001;61(5):1849-54.
2001: Li N; Banin S; Ouyang H; Li G C; Courtois G; Shiloh Y; Karin M; Rotman G
ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks.
The Journal of biological chemistry 2001;276(12):8898-903.
2001: Gatei M; Shkedy D; Khanna K K; Uziel T; Shiloh Y; Pandita T K; Lavin M F; Rotman G
Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid.
Oncogene 2001;20(3):289-94.
2001: Shiloh Y; Kastan M B
ATM: genome stability, neuronal development, and cancer cross paths.
Advances in cancer research 2001;83():209-54.
2000: Matsuoka S; Rotman G; Ogawa A; Shiloh Y; Tamai K; Elledge S J
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10389-94.
2000: Shiloh Y
ATM: sounding the double-strand break alarm.
Cold Spring Harbor symposia on quantitative biology 2000;65():527-33.
2000: Ziv Y; Banin S; Lim D S; Canman C E; Kastan M B; Shiloh Y
Expression and assay of recombinant ATM.
Methods in molecular biology (Clifton, N.J.) 2000;99():99-108.
1999: Khosravi R; Maya R; Gottlieb T; Oren M; Shiloh Y; Shkedy D
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):14973-7.
1999: Rotman G; Shiloh Y
ATM: a mediator of multiple responses to genotoxic stress.
Oncogene 1999;18(45):6135-44.
1999: Hassin-Baer S; Bar-Shira A; Gilad S; Galanty Y; Khosravi R; Lossos A; Giladi N; Weitz R; Ben-Zeev B; Goldhammer Y; Shiloh Y
Absence of mutations in ATM, the gene responsible for ataxia telangiectasia in patients with cerebellar ataxia.
Journal of neurology 1999;246(8):716-9.
1999: Sandoval N; Platzer M; Rosenthal A; Dörk T; Bendix R; Skawran B; Stuhrmann M; Wegner R D; Sperling K; Banin S; Shiloh Y; Baumer A; Bernthaler U; Sennefelder H; Brohm M; Weber B H; Schindler D
Characterization of ATM gene mutations in 66 ataxia telangiectasia families.
Human molecular genetics 1999;8(1):69-79.
1998: Rhodes N; D'Souza T; Foster C D; Ziv Y; Kirsch D G; Shiloh Y; Kastan M B; Reinhart P H; Gilmer T M
Defective potassium currents in ataxia telangiectasia fibroblasts.
Genes & development 1998;12(23):3686-92.
1998: Shiloh Y
Ataxia-telangiectasia, ATM and genomic stability: maintaining a delicate balance. Two international workshops on ataxia-telangiectasia, related disorders and the ATM protein.
Biochimica et biophysica acta 1998;1378(2):R11-8.
1998: Eilam R; Peter Y; Elson A; Rotman G; Shiloh Y; Groner Y; Segal M
Selective loss of dopaminergic nigro-striatal neurons in brains of Atm-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12653-6.
1998: Banin S; Moyal L; Shieh S; Taya Y; Anderson C W; Chessa L; Smorodinsky N I; Prives C; Reiss Y; Shiloh Y; Ziv Y
Enhanced phosphorylation of p53 by ATM in response to DNA damage.
Science (New York, N.Y.) 1998;281(5383):1674-7.
1998: Lim D S; Kirsch D G; Canman C E; Ahn J H; Ziv Y; Newman L S; Darnell R B; Shiloh Y; Kastan M B
ATM binds to beta-adaptin in cytoplasmic vesicles.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10146-51.
1998: Gilad S; Chessa L; Khosravi R; Russell P; Galanty Y; Piane M; Gatti R A; Jorgensen T J; Shiloh Y; Bar-Shira A
Genotype-phenotype relationships in ataxia-telangiectasia and variants.
American journal of human genetics 1998;62(3):551-61.
1998: Fukao T; Song X Q; Yoshida T; Tashita H; Kaneko H; Teramoto T; Inoue R; Katamura K; Mayumi M; Hiratani M; Taniguchi N; Arai J; Wakiguchi H; Bar-Shira A; Shiloh Y; Kondo N
Ataxia-telangiectasia in the Japanese population: identification of R1917X, W2491R, R2909G, IVS33+2T-->A, and 7883del5, the latter two being relatively common mutations.
Human mutation 1998;12(5):338-43.
1998: Rotman G; Shiloh Y
ATM: from gene to function.
Human molecular genetics 1998;7(10):1555-63.
1998: Shiloh Y; Bar-Shira A; Galanty Y; Ziv Y
Cloning and expression of large mammalian cDNAs: lessons from ATM.
Genetic engineering 1998;20():239-48.
1998: Fukao T; Tashita H; Teramoto T; Inoue R; Kaneko H; Komiyama K; Bar-Shira A; Gilad S; Shiloh Y; Nishimura M; Kondo N
Novel exonic mutation (5319 G to A) resulting in two aberrantly spliced transcripts of the ATM gene in a Japanese patient with ataxia-telangiectasia.
Human mutation 1998;Suppl 1():S223-5.
1998: Gilad S; Khosravi R; Harnik R; Ziv Y; Shkedy D; Galanty Y; Frydman M; Levi J; Sanal O; Chessa L; Smeets D; Shiloh Y; Bar-Shira A
Identification of ATM mutations using extended RT-PCR and restriction endonuclease fingerprinting, and elucidation of the repertoire of A-T mutations in Israel.
Human mutation 1998;11(1):69-75.
1997: Rotman G; Shiloh Y
Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress?
BioEssays : news and reviews in molecular, cellular and developmental biology 1997;19(10):911-7.
1997: Ziv Y; Bar-Shira A; Pecker I; Russell P; Jorgensen T J; Tsarfati I; Shiloh Y
Recombinant ATM protein complements the cellular A-T phenotype.
Oncogene 1997;15(2):159-67.
1997: Platzer M; Rotman G; Bauer D; Uziel T; Savitsky K; Bar-Shira A; Gilad S; Shiloh Y; Rosenthal A
Ataxia-telangiectasia locus: sequence analysis of 184 kb of human genomic DNA containing the entire ATM gene.
Genome research 1997;7(6):592-605.
1997: Shafman T; Khanna K K; Kedar P; Spring K; Kozlov S; Yen T; Hobson K; Gatei M; Zhang N; Watters D; Egerton M; Shiloh Y; Kharbanda S; Kufe D; Lavin M F
Interaction between ATM protein and c-Abl in response to DNA damage.
Nature 1997;387(6632):520-3.
1997: Savitsky K; Platzer M; Uziel T; Gilad S; Sartiel A; Rosenthal A; Elroy-Stein O; Shiloh Y; Rotman G
Ataxia-telangiectasia: structural diversity of untranslated sequences suggests complex post-transcriptional regulation of ATM gene expression.
Nucleic acids research 1997;25(9):1678-84.
1997: Khanna K K; Yan J; Watters D; Hobson K; Beamish H; Spring K; Shiloh Y; Gatti R A; Lavin M F
Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cells.
The Journal of biological chemistry 1997;272(14):9489-95.
1997: Brown K D; Ziv Y; Sadanandan S N; Chessa L; Collins F S; Shiloh Y; Tagle D A
The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1840-5.
1997: Shiloh Y
Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart.
Annual review of genetics 1997;31():635-62.
1997: Rotman G; Shiloh Y
The ATM gene and protein: possible roles in genome surveillance, checkpoint controls and cellular defence against oxidative stress.
Cancer surveys 1997;29():285-304.
1997: Lavin M F; Shiloh Y
The genetic defect in ataxia-telangiectasia.
Annual review of immunology 1997;15():177-202.
1996: Gilad S; Bar-Shira A; Harnik R; Shkedy D; Ziv Y; Khosravi R; Brown K; Vanagaite L; Xu G; Frydman M; Lavin M F; Hill D; Tagle D A; Shiloh Y
Ataxia-telangiectasia: founder effect among north African Jews.
Human molecular genetics 1996;5(12):2033-7.
1996: Shiloh Y; Rotman G
Ataxia-telangiectasia and the ATM gene: linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpoints.
Journal of clinical immunology 1996;16(5):254-60.
1996: Beamish H; Williams R; Chen P; Khanna K K; Hobson K; Watters D; Shiloh Y; Lavin M
Rapamycin resistance in ataxia-telangiectasia.
Oncogene 1996;13(5):963-70.
1996: Barlow C; Hirotsune S; Paylor R; Liyanage M; Eckhaus M; Collins F; Shiloh Y; Crawley J N; Ried T; Tagle D; Wynshaw-Boris A
Atm-deficient mice: a paradigm of ataxia telangiectasia.
Cell 1996;86(1):159-71.
1996: Pecker I; Avraham K B; Gilbert D J; Savitsky K; Rotman G; Harnik R; Fukao T; Schröck E; Hirotsune S; Tagle D A; Collins F S; Wynshaw-Boris A; Ried T; Copeland N G; Jenkins N A; Shiloh Y; Ziv Y
Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene.
Genomics 1996;35(1):39-45.
1996: Telatar M; Wang Z; Udar N; Liang T; Bernatowska-Matuszkiewicz E; Lavin M; Shiloh Y; Concannon P; Good R A; Gatti R A
Ataxia-telangiectasia: mutations in ATM cDNA detected by protein-truncation screening.
American journal of human genetics 1996;59(1):40-4.
1996: Gilad S; Khosravi R; Shkedy D; Uziel T; Ziv Y; Savitsky K; Rotman G; Smith S; Chessa L; Jorgensen T J; Harnik R; Frydman M; Sanal O; Portnoi S; Goldwicz Z; Jaspers N G; Gatti R A; Lenoir G; Lavin M F; Tatsumi K; Wegner R D; Shiloh Y; Bar-Shira A
Predominance of null mutations in ataxia-telangiectasia.
Human molecular genetics 1996;5(4):433-9.
1996: Uziel T; Savitsky K; Platzer M; Ziv Y; Helbitz T; Nehls M; Boehm T; Rosenthal A; Shiloh Y; Rotman G
Genomic Organization of the ATM gene.
Genomics 1996;33(2):317-20.
1996: Savitsky K; Ziv Y; Bar-Shira A; Gilad S; Tagle D A; Smith S; Uziel T; Sfez S; Nahmias J; Sartiel A; Eddy R L; Shows T B; Collins F S; Shiloh Y; Rotman G
A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.
Genomics 1996;33(2):199-206.
1995: Savitsky K; Sfez S; Tagle D A; Ziv Y; Sartiel A; Collins F S; Shiloh Y; Rotman G
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species.
Human molecular genetics 1995;4(11):2025-32.
1995: Lavin M F; Khanna K K; Beamish H; Spring K; Watters D; Shiloh Y
Relationship of the ataxia-telangiectasia protein ATM to phosphoinositide 3-kinase.
Trends in biochemical sciences 1995;20(10):382-3.
1995: Savitsky K; Bar-Shira A; Gilad S; Rotman G; Ziv Y; Vanagaite L; Tagle D A; Smith S; Uziel T; Sfez S; Ashkenazi M; Pecker I; Frydman M; Harnik R; Patanjali S R; Simmons A; Clines G A; Sartiel A; Gatti R A; Chessa L; Sanal O; Lavin M F; Jaspers N G; Taylor A M; Arlett C F; Miki T; Weissman S M; Lovett M; Collins F S; Shiloh Y
A single ataxia telangiectasia gene with a product similar to PI-3 kinase.
Science (New York, N.Y.) 1995;268(5218):1749-53.
1995: Vanagaite L; James M R; Rotman G; Savitsky K; Bar-Shira A; Gilad S; Ziv Y; Uchenik V; Sartiel A; Collins F S; Sheffield V C; Richard C W; Weissenbach J; Shiloh Y
A high-density microsatellite map of the ataxia-telangiectasia locus.
Human genetics 1995;95(4):451-4.
1995: Rotman G; Vanagaite L; Collins F S; Shiloh Y
Rapid identification of polymorphic CA-repeats in YAC clones.
Molecular biotechnology 1995;3(2):85-92.
1995: Ziv Y; Bar-Shira A; Jorgensen T J; Russell P S; Sartiel A; Shows T B; Eddy R L; Buchwald M; Legerski R; Schimke R T; Shiloh Y
Human cDNA clones that modify radiomimetic sensitivity of ataxia-telangiectasia (group A) cells.
Somatic cell and molecular genetics 1995;21(2):99-111.
1995: Shiloh Y
Ataxia-telangiectasia: closer to unraveling the mystery.
European journal of human genetics : EJHG 1995;3(2):116-38.
1994: Rotman G; Savitski K; Vanagaite L; Bar-Shira A; Ziv Y; Gilad S; Uchenik V; Smith S; Shiloh Y
Physical and genetic mapping at the ATA/ATC locus on chromosome 11q22-23.
International journal of radiation biology 1994;66(6 Suppl):S63-6.
1994: Gatti R A; Lange E; Rotman G; Chen X; Uhrhammer N; Liang T; Chiplunkar S; Yang L; Udar N; Dandekar S; Sheikhavandi S; Wang Z; Yang H M; Polikow J; Elashoff M; Teletar M; Sanal O; Chessa L; McConville C; Taylor M; Shiloh Y; Porras O; Borresen A L; Wegner R D; Curry C; Gerken S; Lange K; Concannon P
Genetic haplotyping of ataxia-telangiectasia families localizes the major gene to an approximately 850 kb region on chromosome 11q23.1.
International journal of radiation biology 1994;66(6 Suppl):S57-62.
1994: Taylor A M; McConville C M; Rotman G; Shiloh Y; Byrd P J
A haplotype common to intermediate radiosensitivity variants of ataxia-telangiectasia in the UK.
International journal of radiation biology 1994;66(6 Suppl):S35-41.
1994: Rotman G; Vanagaite L; Collins F S; Shiloh Y
Three dinucleotide repeat polymorphisms at the ataxia-telangiectasia locus.
Human molecular genetics 1994;3(11):2079.
1994: Rotman G; Savitsky K; Ziv Y; Cole C G; Higgins M J; Bar-Am I; Dunham I; Bar-Shira A; Vanagaite L; Qin S; Zhang J; Nowak N J; Chandrasekharappa S C; Lehrach H; Avivi L; Shows T B; Collins F S; Bentley D R; Shiloh Y
A YAC contig spanning the ataxia-telangiectasia locus (groups A and C) at 11q22-q23.
Genomics 1994;24(2):234-42.
1994: Vanagaite L; Savitsky K; Rotman G; Ziv Y; Gerken S C; White R; Weissenbach J; Gillett G; Benham F J; Richard C W; James M R; Collins F S; Shiloh Y
Physical localization of microsatellite markers at the ataxia-telangiectasia locus at 11q22-q23.
Genomics 1994;22(1):231-3.
1994: Ambrose H J; Byrd P J; McConville C M; Cooper P R; Stankovic T; Riley J H; Shiloh Y; McNamara J O; Fukao T; Taylor A M
A physical map across chromosome 11q22-q23 containing the major locus for ataxia telangiectasia.
Genomics 1994;21(3):612-9.
1994: Kleiman S; Avigad S; Vanagaite L; Shmuelevitz A; David M; Eisensmith R C; Brand N; Schwartz G; Rey F; Munnich A; Woo S L; Shiloh Y
Origins of hyperphenylalaninemia in Israel.
European journal of human genetics : EJHG 1994;2(1):24-34.
1993: McConville C M; Byrd P J; Ambrose H J; Stankovic T; Ziv Y; Bar-Shira A; Vanagaite L; Rotman G; Shiloh Y; Gillett G T
Paired STSs amplified from radiation hybrids, and from associated YACs, identify highly polymorphic loci flanking the ataxia telangiectasia locus on chromosome 11q22-23.
Human molecular genetics 1993;2(7):969-74.
1993: Kleiman S; Li J; Schwartz G; Eisensmith R C; Woo S L; Shiloh Y
Inactivation of phenylalanine hydroxylase by a missense mutation, R270S, in a Palestinian kinship with phenylketonuria.
Human molecular genetics 1993;2(5):605-6.
1993: Kleiman S; Vanagaite L; Bernstein J; Schwartz G; Brand N; Elitzur A; Woo S L; Shiloh Y
Phenylketonuria: variable phenotypic outcomes of the R261Q mutation and maternal PKU in the offspring of a healthy homozygote.
Journal of medical genetics 1993;30(4):284-8.
1993: Mor O; Ranzani G N; Ravia Y; Rotman G; Gutman M; Manor A; Amadori D; Houldsworth J; Hollstein M; Schwab M; Shiloh Y
DNA amplification in human gastric carcinomas.
Cancer genetics and cytogenetics 1993;65(2):111-4.
1993: Weinstein M; Eisensmith R C; Abadie V; Avigad S; Lyonnet S; Schwartz G; Munnich A; Woo S L; Shiloh Y
A missense mutation, S349P, completely inactivates phenylalanine hydroxylase in north African Jews with phenylketonuria.
Human genetics 1993;90(6):645-9.
1992: Bar-Am I; Mor O; Yeger H; Shiloh Y; Avivi L
Detection of amplified DNA sequences in human tumor cell lines by fluorescence in situ hybridization.
Genes, chromosomes & cancer 1992;4(4):314-20.
1992: Shiloh Y; Mor O; Manor A; Bar-Am I; Rotman G; Eubanks J; Gutman M; Ranzani G N; Houldsworth J; Evans G
DNA sequences amplified in cancer cells: an interface between tumor biology and human genome analysis.
Mutation research 1992;276(3):329-37.
1992: Ziv Y; Frydman M; Lange E; Zelnik N; Rotman G; Julier C; Jaspers N G; Dagan Y; Abeliovicz D; Dar H; Borochowitz Z; Lathrop M; Gatti R A; Shiloh Y
Ataxia-telangiectasia: linkage analysis in highly inbred Arab and Druze families and differentiation from an ataxia-microcephaly-cataract syndrome.
Human genetics 1992;88(6):619-26.
1992: Kleiman S; Schwartz G; Woo S L; Shiloh Y
A 22-bp deletion in the phenylalanine hydroxylase gene causing phenylketonuria in an Arab family.
Human mutation 1992;1(4):344-6.
1992: Kleiman S; Bernstein J; Schwartz G; Eisensmith R C; Woo S L; Shiloh Y
A defective splice site at the phenylalanine hydroxylase gene in phenylketonuria and benign hyperphenylalaninemia among Palestinian Arabs.
Human mutation 1992;1(4):340-3.
1991: Foroud T; Wei S; Ziv Y; Sobel E; Lange E; Chao A; Goradia T; Huo Y; Tolun A; Chessa L; Charmley P; Sanal O; Salman N; Julier C; Concannon P; McConville C; Taylor A M; Shiloh Y; Lange S K; Gatti R A
Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: linkage analysis of 111 families by an international consortium.
American journal of human genetics 1991;49(6):1263-79.
1991: Avigad S; Kleiman S; Weinstein M; Cohen B E; Schwartz G; Woo S L; Shiloh Y
Compound heterozygosity in nonphenylketonuria hyperphenylalanemia: the contribution of mutations for classical phenylketonuria.
American journal of human genetics 1991;49(2):393-9.
1991: Ziv Y; Rotman G; Frydman M; Dagan J; Cohen T; Foroud T; Gatti R A; Shiloh Y
The ATC (ataxia-telangiectasia complementation group C) locus localizes to 11q22-q23.
Genomics 1991;9(2):373-5.
1991: Mor O; Messinger Y; Rotman G; Bar-Am I; Ravia Y; Eddy R L; Shows T B; Park J G; Gazdar A F; Shiloh Y
Novel DNA sequences at chromosome 10q26 are amplified in human gastric carcinoma cell lines: molecular cloning by competitive DNA reassociation.
Nucleic acids research 1991;19(1):117-23.
1990: Shiloh Y; Litvak G; Ziv Y; Lehner T; Sandkuyl L; Hildesheimer M; Buchris V; Cremers F P; Szabo P; White B N
Genetic mapping of X-linked albinism-deafness syndrome (ADFN) to Xq26.3-q27.I.
American journal of human genetics 1990;47(1):20-7.
1990: Yeger H; Mor O; Pawlin G; Kaplinsky C; Shiloh Y
Importance of phenotypic and molecular characterization for identification of a neuroepithelioma tumor cell line, NUB-20.
Cancer research 1990;50(9):2794-802.
1990: Avigad S; Cohen B E; Bauer S; Schwartz G; Frydman M; Woo S L; Niny Y; Shiloh Y
A single origin of phenylketonuria in Yemenite Jews.
Nature 1990;344(6262):168-70.
1989: Shiloh Y; Parshad R; Frydman M; Sanford K K; Portnoi S; Ziv Y; Jones G M
G2 chromosomal radiosensitivity in families with ataxia-telangiectasia.
Human genetics 1989;84(1):15-8.
1989: Ziv Y; Jaspers N G; Etkin S; Danieli T; Trakhtenbrot L; Amiel A; Ravia Y; Shiloh Y
Cellular and molecular characteristics of an immortalized ataxia-telangiectasia (group AB) cell line.
Cancer research 1989;49(9):2495-501.
1989: Ziv Y; Amiel A; Jaspers N G; Berkel A I; Shiloh Y
Ataxia-telangiectasia: a variant with altered in vitro phenotype of fibroblast cells.
Mutation research 1989;210(2):211-9.

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