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Nobuyuki Shima

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Chemicals & Drugs

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Mouse

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Tatsuo Suda; Nobuyuki Shima; Kanji Higashio
[Merger of bone biology and immunology].
J M Quinn; Kanami Itoh; Nobuyuki Udagawa; K Hausler; Hisataka Yasuda; Nobuyuki Shima; Atsuko Mizuno; Kanji Higashio; Naoyuki Takahashi; Toshio Suda; TJ Martin; MT Gillespie
Transforming growth factor beta affects osteoclast differentiation via direct and indirect actions.
S H Oh; Masahiro Miyazaki; H Kouchi; Y Inoue; M Sakaguchi; T Tsuji; Nobuyuki Shima; Kanji Higashio; Masayoshi Namba
Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro.

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All Publications

2002: Tatsuo Suda; Nobuyuki Shima; Kanji Higashio
[Merger of bone biology and immunology].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2002;47(13):1837-43.
2001: J M Quinn; Kanami Itoh; Nobuyuki Udagawa; K Hausler; Hisataka Yasuda; Nobuyuki Shima; Atsuko Mizuno; Kanji Higashio; Naoyuki Takahashi; Toshio Suda; TJ Martin; MT Gillespie
Transforming growth factor beta affects osteoclast differentiation via direct and indirect actions.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(10):1787-94.
2000: S H Oh; Masahiro Miyazaki; H Kouchi; Y Inoue; M Sakaguchi; T Tsuji; Nobuyuki Shima; Kanji Higashio; Masayoshi Namba
Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro.
Biochemical and biophysical research communications 2000;279(2):500-4.
2000: Kazuo Kobayashi; Naoyuki Takahashi; E Jimi; Nobuyuki Udagawa; Masamichi Takami; S Kotake; N Nakagawa; Masahiko Kinosaki; Kyoji Yamaguchi; Nobuyuki Shima; Hisataka Yasuda; T Morinaga; Kanji Higashio; TJ Martin; Toshio Suda
Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction.
The Journal of experimental medicine 2000;191(2):275-86.
1999: N Nakagawa; Hisataka Yasuda; Kazuki Yano; S i Mochizuki; N Kobayashi; H Fujimoto; Nobuyuki Shima; T Morinaga; D Chikazu; H Kawaguchi; Kanji Higashio
Basic fibroblast growth factor induces osteoclast formation by reciprocally regulating the production of osteoclast differentiation factor and osteoclastogenesis inhibitory factor in mouse osteoblastic cells.
Biochemical and biophysical research communications 1999;265(1):158-63.
1999: N Nakagawa; Hisataka Yasuda; Kazuki Yano; S i Mochizuki; N Kobayashi; H Fujimoto; Kyoji Yamaguchi; Nobuyuki Shima; T Morinaga; Kanji Higashio
Basic fibroblast growth factor inhibits osteoclast formation induced by 1alpha,25-dihydroxyvitamin D(3) through suppressing the production of osteoclast differentiation factor.
Biochemical and biophysical research communications 1999;265(1):45-50.
1999: Hisataka Yasuda; Nobuyuki Shima; N Nakagawa; Kyoji Yamaguchi; Masahiko Kinosaki; Masaaki Goto; S i Mochizuki; Eisuke Tsuda; T Morinaga; Nobuyuki Udagawa; Naoyuki Takahashi; Toshio Suda; Kanji Higashio
A novel molecular mechanism modulating osteoclast differentiation and function.
Bone 1999;25(1):109-13.
1999: Kunihiko Kodaira; K Kodaira; Atsuko Mizuno; Hisataka Yasuda; Nobuyuki Shima; Akihiko Murakami; M Ueda; Kanji Higashio
Cloning and characterization of the gene encoding mouse osteoclast differentiation factor.
Gene 1999;230(1):121-7.
1998: N Nakagawa; Masahiko Kinosaki; Kyoji Yamaguchi; Nobuyuki Shima; Hisataka Yasuda; Kazuki Yano; T Morinaga; Kanji Higashio
RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis.
Biochemical and biophysical research communications 1998;253(2):395-400.
1998: Nobuyuki Shima; D B Stolz; Masahiro Miyazaki; EIICHI GOHDA; Kanji Higashio; G K Michalopoulos
Possible involvement of p21/waf1 in the growth inhibition of HepG2 cells induced by hepatocyte growth factor.
Journal of cellular physiology 1998;177(1):130-6.
1998: Atsuko Mizuno; N Amizuka; K Irie; Akihiko Murakami; Nobuaki Fujise; T Kanno; Y Sato; N Nakagawa; Hisataka Yasuda; S i Mochizuki; T Gomibuchi; Kazuki Yano; Nobuyuki Shima; Naohiro Washida; Eisuke Tsuda; T Morinaga; Kanji Higashio; H Ozawa
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin.
Biochemical and biophysical research communications 1998;247(3):610-5.
1998: K Tsukii; Nobuyuki Shima; S i Mochizuki; Kyoji Yamaguchi; Masahiko Kinosaki; Kazuki Yano; Osamu Shibata; Nobuyuki Udagawa; Hisataka Yasuda; Toshio Suda; Kanji Higashio
Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha,25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of bone.
Biochemical and biophysical research communications 1998;246(2):337-41.
1998: K Matsuzaki; Nobuyuki Udagawa; Naoyuki Takahashi; Kyoji Yamaguchi; Hisataka Yasuda; Nobuyuki Shima; T Morinaga; Yoshiaki Toyama; Y Yabe; Kanji Higashio; Toshio Suda
Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures.
Biochemical and biophysical research communications 1998;246(1):199-204.
1998: Hisataka Yasuda; Nobuyuki Shima; N Nakagawa; Kyoji Yamaguchi; Masahiko Kinosaki; S i Mochizuki; Akihiro Tomoyasu; Kazuki Yano; Masaaki Goto; Akihiko Murakami; Eisuke Tsuda; T Morinaga; Kanji Higashio; Nobuyuki Udagawa; Naoyuki Takahashi; Toshio Suda
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3597-602.
1998: Hisataka Yasuda; Nobuyuki Shima; N Nakagawa; S i Mochizuki; Kazuki Yano; Nobuaki Fujise; Y Sato; Masaaki Goto; Kyoji Yamaguchi; M Kuriyama; T Kanno; Akihiko Murakami; Eisuke Tsuda; T Morinaga; Kanji Higashio
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro.
Endocrinology 1998;139(3):1329-37.
1994: Nobuyuki Shima; Eisuke Tsuda; Masaaki Goto; Kazuki Yano; H Hayasaka; M Ueda; Kanji Higashio
Hepatocyte growth factor and its variant with a deletion of five amino acids are distinguishable in their biological activity and tertiary structure.
Biochemical and biophysical research communications 1994;200(2):808-15.
1993: Kanji Higashio; Nobuyuki Shima
Tumor cytotoxic activity of HGF-SF.
EXS 1993;65():351-68.
1992: Nobuyuki Shima; Kanji Higashio
[Structure and biological property of fibroblast-derived tumor cytotoxic factor (F-TCF)].
Nihon rinsho. Japanese journal of clinical medicine 1992;50(8):1962-6.
1991: Nobuyuki Shima; M Nagao; F Ogaki; Eisuke Tsuda; A Murakami; Kanji Higashio
Tumor cytotoxic factor/hepatocyte growth factor from human fibroblasts: cloning of its cDNA, purification and characterization of recombinant protein.
Biochemical and biophysical research communications 1991;180(2):1151-8.
1991: A Morimoto; K Okamura; R Hamanaka; Y Sato; Nobuyuki Shima; Kanji Higashio; Michihiko Kuwano
Hepatocyte growth factor modulates migration and proliferation of human microvascular endothelial cells in culture.
Biochemical and biophysical research communications 1991;179(2):1042-9.
1991: Nobuyuki Shima; Kanji Higashio; H Ogaki; K Okabe
ELISA for F-TCF (human hepatocyte growth factor/hHGF)/fibroblast-derived tumor cytotoxic factor antigen employing monoclonal antibodies and its application to patients with liver diseases.
Gastroenterologia Japonica 1991;26(4):477-82.
1991: Nobuyuki Shima; Y Itagaki; M Nagao; H Yasuda; T Morinaga; Kanji Higashio
A fibroblast-derived tumor cytotoxic factor/F-TCF (hepatocyte growth factor/HGF) has multiple functions in vitro.
Cell biology international reports 1991;15(5):397-408.
1991: A Suzuki; Y Itagaki; Nobuyuki Shima; S Mitsuda; Kanji Higashio; G Kawanishi
Role of Ca2+ in t-PA production by human embryonic lung diploid fibroblast, IMR-90 cells, stimulated by proteose peptone.
Cellular signalling 1991;3(2):99-105.
1990: Kanji Higashio; Nobuyuki Shima; Masaaki Goto; Y Itagaki; M Nagao; H Yasuda; T Morinaga
Identity of a tumor cytotoxic factor from human fibroblasts and hepatocyte growth factor.
Biochemical and biophysical research communications 1990;170(1):397-404.