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Shunichi Shimasaki

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Kirsten J McTavish; David Nonis; Yvonne D Hoang; Shunichi Shimasaki
Granulosa cell tumor mutant FOXL2(C134W) suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cells.
David Nonis; Kirsten J McTavish; Shunichi Shimasaki
Essential but differential role of FOXL2(wt) and FOXL2(C134W) in GDF-9 stimulation of follistatin transcription in co-operation with Smad3 in the human granulosa cell line COV434.
Kenichi Inagaki; Shunichi Shimasaki
Impaired production of BMP-15 and GDF-9 mature proteins derived from proproteins WITH mutations in the proregion.

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2013: Kirsten J McTavish; David Nonis; Yvonne D Hoang; Shunichi Shimasaki
Granulosa cell tumor mutant FOXL2(C134W) suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cells.
Molecular and cellular endocrinology 2013;372(1-2):57-64.
2013: David Nonis; Kirsten J McTavish; Shunichi Shimasaki
Essential but differential role of FOXL2(wt) and FOXL2(C134W) in GDF-9 stimulation of follistatin transcription in co-operation with Smad3 in the human granulosa cell line COV434.
Molecular and cellular endocrinology 2013;372(1-2):42-8.
2010: Kenichi Inagaki; Shunichi Shimasaki
Impaired production of BMP-15 and GDF-9 mature proteins derived from proproteins WITH mutations in the proregion.
Molecular and cellular endocrinology 2010;328(1-2):1-7.
2008: Heather E McMahon; Osamu Hashimoto; Pamela L Mellon; Shunichi Shimasaki
Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice.
Endocrinology 2008;149(6):2807-15.
2008: Deborah S Wachs; Mickey S Coffler; Pamela J Malcom; Shunichi Shimasaki; Jeffrey Chang
Increased androgen response to follicle-stimulating hormone administration in women with polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 2008;93(5):1827-33.
2008: Seiji Saito; Keiichi Yano; Shweta Sharma; Heather E McMahon; Shunichi Shimasaki
Characterization of the post-translational modification of recombinant human BMP-15 mature protein.
Protein science : a publication of the Protein Society 2008;17(2):362-70.
2008: Heather E McMahon; Shweta Sharma; Shunichi Shimasaki
Phosphorylation of bone morphogenetic protein-15 and growth and differentiation factor-9 plays a critical role in determining agonistic or antagonistic functions.
Endocrinology 2008;149(2):812-7.
2006: Osamu Yoshino; Heather E McMahon; Shweta Sharma; Shunichi Shimasaki
A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouse.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10678-83.
2005: Fumio Otsuka; R Kelly Moore; Xia Wang; Shweta Sharma; Tomoko Miyoshi; Shunichi Shimasaki
Essential role of the oocyte in estrogen amplification of follicle-stimulating hormone signaling in granulosa cells.
Endocrinology 2005;146(8):3362-7.
2005: R Kelly Moore; Shunichi Shimasaki
Molecular biology and physiological role of the oocyte factor, BMP-15.
Molecular and cellular endocrinology 2005;234(1-2):67-73.
2005: Osamu Hashimoto; R Kelly Moore; Shunichi Shimasaki
Posttranslational processing of mouse and human BMP-15: potential implication in the determination of ovulation quota.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(15):5426-31.
2004: R Kelly Moore; Gregory F Erickson; Shunichi Shimasaki
Are BMP-15 and GDF-9 primary determinants of ovulation quota in mammals?
Trends in endocrinology and metabolism: TEM 2004;15(8):356-61.
2004: G F Erickson; L Fuqua; Shunichi Shimasaki
Analysis of spatial and temporal expression patterns of bone morphogenetic protein family members in the rat uterus over the estrous cycle.
The Journal of endocrinology 2004;182(2):203-17.
2004: Motozumi Matsui; Barbara Sonntag; Seong Soo Hwang; Tara Byerly; Ariel Hourvitz; Eli Y Adashi; Shunichi Shimasaki; Gregory F Erickson
Pregnancy-associated plasma protein-a production in rat granulosa cells: stimulation by follicle-stimulating hormone and inhibition by the oocyte-derived bone morphogenetic protein-15.
Endocrinology 2004;145(8):3686-95.
2004: Wu Xiang Liao; R Kelly Moore; Shunichi Shimasaki
Functional and molecular characterization of naturally occurring mutations in the oocyte-secreted factors bone morphogenetic protein-15 and growth and differentiation factor-9.
The Journal of biological chemistry 2004;279(17):17391-6.
2004: Shunichi Shimasaki; R Kelly Moore; Fumio Otsuka; Gregory F Erickson
The bone morphogenetic protein system in mammalian reproduction.
Endocrine reviews 2004;25(1):72-101.
2003: Wu Xiang Liao; R Kelly Moore; Fumio Otsuka; Shunichi Shimasaki
Effect of intracellular interactions on the processing and secretion of bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9. Implication of the aberrant ovarian phenotype of BMP-15 mutant sheep.
The Journal of biological chemistry 2003;278(6):3713-9.
2003: Gregory F Erickson; Shunichi Shimasaki
The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle.
Reproductive biology and endocrinology : RB&E 2003;1():9.
2003: R Kelly Moore; Fumio Otsuka; Shunichi Shimasaki
Molecular basis of bone morphogenetic protein-15 signaling in granulosa cells.
The Journal of biological chemistry 2003;278(1):304-10.
2003: Shunichi Shimasaki; R Kelly Moore; Gregory F Erickson; Fumio Otsuka
The role of bone morphogenetic proteins in ovarian function.
Reproduction (Cambridge, England) Supplement 2003;61():323-37.
2002: Fumio Otsuka; Shunichi Shimasaki
A novel function of bone morphogenetic protein-15 in the pituitary: selective synthesis and secretion of FSH by gonadotropes.
Endocrinology 2002;143(12):4938-41.
2002: Fumio Otsuka; Shunichi Shimasaki
A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: its role in regulating granulosa cell mitosis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8060-5.
2002: Masashi Nakatani; Norio Yamakawa; Toshiya Matsuzaki; Shunichi Shimasaki; Hiromu Sugino; Kunihiro Tsuchida
Genomic organization and promoter analysis of mouse follistatin-related gene (FLRG).
Molecular and cellular endocrinology 2002;189(1-2):117-23.
2002: Fabio Lopes Teixeira Filho; Edmund C Baracat; Taek Hoo Lee; Chang Suk Suh; Motozumi Matsui; Jeffrey Chang; Shunichi Shimasaki; Gregory F Erickson
Aberrant expression of growth differentiation factor-9 in oocytes of women with polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 2002;87(3):1337-44.
2001: Fumio Otsuka; R Kelly Moore; Shun-ichiro Iemura; N Ueno; Shunichi Shimasaki
Follistatin inhibits the function of the oocyte-derived factor BMP-15.
Biochemical and biophysical research communications 2001;289(5):961-6.
2001: R Kelly Moore; Fumio Otsuka; Shunichi Shimasaki
Role of ERK1/2 in the differential synthesis of progesterone and estradiol by granulosa cells.
Biochemical and biophysical research communications 2001;289(4):796-800.
2001: Gregory F Erickson; Shunichi Shimasaki
The physiology of folliculogenesis: the role of novel growth factors.
Fertility and sterility 2001;76(5):943-9.
2001: W S Lee; Fumio Otsuka; R Kelly Moore; Shunichi Shimasaki
Effect of bone morphogenetic protein-7 on folliculogenesis and ovulation in the rat.
Biology of reproduction 2001;65(4):994-9.
2001: Fumio Otsuka; R Kelly Moore; Shunichi Shimasaki
Biological function and cellular mechanism of bone morphogenetic protein-6 in the ovary.
The Journal of biological chemistry 2001;276(35):32889-95.
2001: Fumio Otsuka; S Yamamoto; Gregory F Erickson; Shunichi Shimasaki
Bone morphogenetic protein-15 inhibits follicle-stimulating hormone (FSH) action by suppressing FSH receptor expression.
The Journal of biological chemistry 2001;276(14):11387-92.
2000: Fumio Otsuka; Z Yao; T Lee; S Yamamoto; Gregory F Erickson; Shunichi Shimasaki
Bone morphogenetic protein-15. Identification of target cells and biological functions.
The Journal of biological chemistry 2000;275(50):39523-8.
2000: Osamu Hashimoto; Nana Kawasaki; Kunihiro Tsuchida; Shunichi Shimasaki; Takao Hayakawa; Hiromu Sugino
Difference between follistatin isoforms in the inhibition of activin signalling: activin neutralizing activity of follistatin isoforms is dependent on their affinity for activin.
Cellular signalling 2000;12(8):565-71.
2000: Gregory F Erickson; Shunichi Shimasaki
The role of the oocyte in folliculogenesis.
Trends in endocrinology and metabolism: TEM 2000;11(5):193-8.
2000: Takamasa S Yamamoto; Shun-ichiro Iemura; C Takagi; Shunichi Shimasaki; Naoto Ueno
Characterization of follistatin isoforms in early Xenopus embryogenesis.
The International journal of developmental biology 2000;44(4):341-8.
1999: Shunichi Shimasaki; R J Zachow; D Li; H Kim; Shun-ichiro Iemura; N Ueno; K Sampath; Jeffrey Chang; Gregory F Erickson
A functional bone morphogenetic protein system in the ovary.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(13):7282-7.
1998: Shun-ichiro Iemura; Takamasa S Yamamoto; C Takagi; H Uchiyama; Tohru Natsume; Shunichi Shimasaki; H Sugino; Naoto Ueno
Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9337-42.
1998: T Kubo; Shunichi Shimasaki; H Kim; D Li; Gregory F Erickson
Activin-induced inhibin alpha-subunit production by rat granulosa cells requires endogenous insulin-like growth factor-I.
Biology of reproduction 1998;58(3):712-8.
1998: D Li; T Kubo; H Kim; Shunichi Shimasaki; Gregory F Erickson
Endogenous insulin-like growth factor-I is obligatory for stimulation of rat inhibin alpha-subunit expression by follicle-stimulating hormone.
Biology of reproduction 1998;58(1):219-25.
1997: F Piferrer; D Li; Shunichi Shimasaki; Gregory F Erickson
Transforming growth factor-alpha stimulates insulin-like growth factor binding protein-4 (IGFBP-4) expression and blocks follicle-stimulating hormone regulation of IGFBP-4 production in rat granulosa cells.
Molecular and cellular endocrinology 1997;133(1):9-17.
1997: Osamu Hashimoto; Tetsuya Nakamura; H Shoji; Shunichi Shimasaki; Y Hayashi; Hiromu Sugino
A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells. Endocytotic degradation of activin and its acceleration by follistatin associated with cell-surface heparan sulfate.
The Journal of biological chemistry 1997;272(21):13835-42.
1995: Gregory F Erickson; M R Girvigian; A R Sadighian; A Nakatani; N Ling; Shunichi Shimasaki
Tissue specific and cyclic expression of insulin-like growth factor binding proteins-1,-2,-3,-4,-5,-6 in the rat oviduct.
Endocrine 1995;3(9):667-76.
1995: Gregory F Erickson; D G Chung; A Sit; L V DePaolo; Shunichi Shimasaki; N Ling
Follistatin concentrations in follicular fluid of normal and polycystic ovaries.
Human reproduction (Oxford, England) 1995;10(8):2120-4.
1995: Gregory F Erickson; D Li; Shunichi Shimasaki; N Ling; S R Weitsman; D A Magoffin
Insulin-like growth factor-1 (IGF-1) stimulates the IGF binding protein system in rat theca interstitial cells.
Endocrine 1995;3(7):525-31.
1995: N Onoda; D Li; G Mickey; G Erickson; Shunichi Shimasaki
Gonadotropin-releasing hormone overcomes follicle-stimulating hormone's inhibition of insulin-like growth factor-5 synthesis and promotion of its degradation in rat granulosa cells.
Molecular and cellular endocrinology 1995;110(1-2):17-25.
1995: S Sumitomo; S Inouye; X J Liu; N Ling; Shunichi Shimasaki
The heparin binding site of follistatin is involved in its interaction with activin.
Biochemical and biophysical research communications 1995;208(1):1-9.
1994: M R Girvigian; A Nakatani; N Ling; Shunichi Shimasaki; Gregory F Erickson
Insulin-like growth factor binding proteins show distinct patterns of expression in the rat uterus.
Biology of reproduction 1994;51(2):296-302.
1994: Gregory F Erickson; D Li; R Sadrkhanloo; X J Liu; Shunichi Shimasaki; N Ling
Extrapituitary actions of gonadotropin-releasing hormone: stimulation of insulin-like growth factor-binding protein-4 and atresia.
Endocrinology 1994;134(3):1365-72.
1993: Gregory F Erickson; A Nakatani; N Ling; Shunichi Shimasaki
Insulin-like growth factor binding protein-3 gene expression is restricted to involuting corpora lutea in rat ovaries.
Endocrinology 1993;133(3):1147-57.
1993: K Miyanaga; Gregory F Erickson; L V DePaolo; N Ling; Shunichi Shimasaki
Differential control of activin, inhibin and follistatin proteins in cultured rat granulosa cells.
Biochemical and biophysical research communications 1993;194(1):253-8.
1993: M Mercado; Shunichi Shimasaki; N Ling; L DePaolo
Effects of estrous cycle stage and pregnancy on follistatin gene expression and immunoreactivity in rat reproductive tissues: progesterone is implicated in regulating uterine gene expression.
Endocrinology 1993;132(4):1774-81.
1993: X Zhu; N Ling; Shunichi Shimasaki
Structural characterization of the rat insulin-like growth factor binding protein-6 gene.
Biochemical and biophysical research communications 1993;191(3):1237-43.
1993: K Miyanaga; Shunichi Shimasaki
Structural and functional characterization of the rat follistatin (activin-binding protein) gene promoter.
Molecular and cellular endocrinology 1993;92(1):99-109.
1993: N C Ling; X J Liu; M Malkowski; Y L Guo; Gregory F Erickson; Shunichi Shimasaki
Structural and functional studies of insulin-like growth factor binding proteins in the ovary.
Growth regulation 1993;3(1):70-4.
1993: X J Liu; M Malkowski; Y Guo; Gregory F Erickson; Shunichi Shimasaki; N Ling
Development of specific antibodies to rat insulin-like growth factor-binding proteins (IGFBP-2 to -6): analysis of IGFBP production by rat granulosa cells.
Endocrinology 1993;132(3):1176-83.
1993: L Gao; N Ling; Shunichi Shimasaki
Structure of the rat insulin-like growth factor binding protein-4 gene.
Biochemical and biophysical research communications 1993;190(3):1053-9.
1993: X Zhu; N Ling; Shunichi Shimasaki
Cloning of the rat insulin- like growth factor binding protein-5 gene and DNA sequence analysis of its promoter region.
Biochemical and biophysical research communications 1993;190(3):1045-52.
1992: S Inouye; N Ling; Shunichi Shimasaki
Localization of the heparin binding site of follistatin.
Molecular and cellular endocrinology 1992;90(1):1-6.
1992: Gregory F Erickson; A Nakatani; N Ling; Shunichi Shimasaki
Localization of insulin-like growth factor-binding protein-5 messenger ribonucleic acid in rat ovaries during the estrous cycle.
Endocrinology 1992;130(4):1867-78.
1992: Gregory F Erickson; A Nakatani; N Ling; Shunichi Shimasaki
Cyclic changes in insulin-like growth factor-binding protein-4 messenger ribonucleic acid in the rat ovary.
Endocrinology 1992;130(2):625-36.
1991: L V DePaolo; T A Bicsak; Gregory F Erickson; Shunichi Shimasaki; N Ling
Follistatin and activin: a potential intrinsic regulatory system within diverse tissues.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1991;198(1):500-12.
1991: A Nakatani; Shunichi Shimasaki; Gregory F Erickson; N Ling
Tissue-specific expression of four insulin-like growth factor-binding proteins (1, 2, 3, and 4) in the rat ovary.
Endocrinology 1991;129(3):1521-9.
1991: S Inouye; Y Guo; N Ling; Shunichi Shimasaki
Site-specific mutagenesis of human follistatin.
Biochemical and biophysical research communications 1991;179(1):352-8.
1991: S Inouye; Y Guo; L DePaolo; M Shimonaka; N Ling; Shunichi Shimasaki
Recombinant expression of human follistatin with 315 and 288 amino acids: chemical and biological comparison with native porcine follistatin.
Endocrinology 1991;129(2):815-22.
1991: A Nakatani; Shunichi Shimasaki; L V Depaolo; Gregory F Erickson; N Ling
Cyclic changes in follistatin messenger ribonucleic acid and its protein in the rat ovary during the estrous cycle.
Endocrinology 1991;129(2):603-11.
1991: Shunichi Shimasaki; L Gao; M Shimonaka; N Ling
Isolation and molecular cloning of insulin-like growth factor-binding protein-6.
Molecular endocrinology (Baltimore, Md.) 1991;5(7):938-48.
1991: Shunichi Shimasaki; M Shimonaka; H P Zhang; N Ling
Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human.
The Journal of biological chemistry 1991;266(16):10646-53.
1991: M Shimonaka; S Inouye; Shunichi Shimasaki; N Ling
Follistatin binds to both activin and inhibin through the common subunit.
Endocrinology 1991;128(6):3313-5.
1991: Shunichi Shimasaki; N Ling
Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6).
Progress in growth factor research 1991;3(4):243-66.
1990: Shunichi Shimasaki; F Uchiyama; M Shimonaka; N Ling
Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human.
Molecular endocrinology (Baltimore, Md.) 1990;4(10):1451-8.
1990: N Ling; L V DePaolo; T A Bicsak; Shunichi Shimasaki
Novel ovarian regulatory peptides: inhibin, activin, and follistatin.
Clinical obstetrics and gynecology 1990;33(3):690-702.
1990: Shunichi Shimasaki; M Shimonaka; M Ui; S Inouye; F Shibata; N Ling
Structural characterization of a follicle-stimulating hormone action inhibitor in porcine ovarian follicular fluid. Its identification as the insulin-like growth factor-binding protein.
The Journal of biological chemistry 1990;265(4):2198-202.
1989: Shunichi Shimasaki; A Koba; M Mercado; M Shimonaka; N Ling
Complementary DNA structure of the high molecular weight rat insulin-like growth factor binding protein (IGF-BP3) and tissue distribution of its mRNA.
Biochemical and biophysical research communications 1989;165(2):907-12.
1989: M Shimonaka; R Schroeder; Shunichi Shimasaki; N Ling
Identification of a novel binding protein for insulin-like growth factors in adult rat serum.
Biochemical and biophysical research communications 1989;165(1):189-95.
1989: M Ui; M Shimonaka; Shunichi Shimasaki; N Ling
An insulin-like growth factor-binding protein in ovarian follicular fluid blocks follicle-stimulating hormone-stimulated steroid production by ovarian granulosa cells.
Endocrinology 1989;125(2):912-6.
1989: Shunichi Shimasaki; M Koga; M L Buscaglia; Donna M Simmons; T A Bicsak; N Ling
Follistatin gene expression in the ovary and extragonadal tissues.
Molecular endocrinology (Baltimore, Md.) 1989;3(4):651-9.
1988: Shunichi Shimasaki; N Emoto; A Koba; M Mercado; F Shibata; K Cooksey; Andrew Baird; N Ling
Complementary DNA cloning and sequencing of rat ovarian basic fibroblast growth factor and tissue distribution study of its mRNA.
Biochemical and biophysical research communications 1988;157(1):256-63.
1988: Shunichi Shimasaki; M Koga; F Esch; K Cooksey; M Mercado; A Koba; N Ueno; S Y Ying; N Ling; Roger Guillemin
Primary structure of the human follistatin precursor and its genomic organization.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4218-22.
1988: Shunichi Shimasaki; M Koga; F Esch; M Mercado; K Cooksey; A Koba; N Ling
Porcine follistatin gene structure supports two forms of mature follistatin produced by alternative splicing.
Biochemical and biophysical research communications 1988;152(2):717-23.
1987: F S Esch; Shunichi Shimasaki; M Mercado; K Cooksey; N Ling; S Ying; N Ueno; Roger Guillemin
Structural characterization of follistatin: a novel follicle-stimulating hormone release-inhibiting polypeptide from the gonad.
Molecular endocrinology (Baltimore, Md.) 1987;1(11):849-55.
1987: Larry W Fisher; Pamela Robey; N Tuross; A S Otsuka; D A Tepen; F S Esch; Shunichi Shimasaki; J D Termine
The Mr 24,000 phosphoprotein from developing bone is the NH2-terminal propeptide of the alpha 1 chain of type I collagen.
The Journal of biological chemistry 1987;262(28):13457-63.
1987: F S Esch; Shunichi Shimasaki; K Cooksey; M Mercado; A J Mason; S Y Ying; N Ueno; N Ling
Complementary deoxyribonucleic acid (cDNA) cloning and DNA sequence analysis of rat ovarian inhibins.
Molecular endocrinology (Baltimore, Md.) 1987;1(5):388-96.
1986: F S Esch; A J Mason; K Cooksey; M Mercado; Shunichi Shimasaki
Cloning and DNA sequence analysis of the cDNA for the precursor of the beta chain of bovine follicle stimulating hormone.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(17):6618-21.