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Hiroyuki Shimizu

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Akiko Katano-Toki; Koshi Hashimoto; Sumiyasu Ishii; Takahiro Ishizuka; Shuichi Okada; Atsushi Ozawa; Tsugumichi Saito; Tetsurou Satoh; Nobuyuki Shibusawa; Hiroyuki Shimizu; Takuya Tomaru; Takafumi Tsuchiya; Masanobu Yamada; Satoshi Yoshino; Masatomo Mori
THRAP3 Interacts with HELZ2 and Plays a Novel Role in Adipocyte Differentiation.
Yuko Tagaya; Masanobu Yamada; Koshi Hashimoto; Atsuko Miura; Kihachi Ohshima; Shuichi Okada; Aya Osaki; Tetsurou Satoh; Hiroyuki Shimizu; Masatomo Mori
Secreted nucleobindin-2 inhibits 3T3-L1 adipocyte differentiation.
Aya Osaki; Hiroyuki Shimizu; Yoko Suzuki; Noriko Ishizuka; Masatomo Mori; Shuji Inoue
Enhanced expression of nesfatin/nucleobindin-2 in white adipose tissue of ventromedial hypothalamus-lesioned rats.

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2013: Akiko Katano-Toki; Koshi Hashimoto; Sumiyasu Ishii; Takahiro Ishizuka; Shuichi Okada; Atsushi Ozawa; Tsugumichi Saito; Tetsurou Satoh; Nobuyuki Shibusawa; Hiroyuki Shimizu; Takuya Tomaru; Takafumi Tsuchiya; Masanobu Yamada; Satoshi Yoshino; Masatomo Mori
THRAP3 Interacts with HELZ2 and Plays a Novel Role in Adipocyte Differentiation.
Molecular endocrinology (Baltimore, Md.) 2013;27(5):769-80.
2012: Yuko Tagaya; Masanobu Yamada; Koshi Hashimoto; Atsuko Miura; Kihachi Ohshima; Shuichi Okada; Aya Osaki; Tetsurou Satoh; Hiroyuki Shimizu; Masatomo Mori
Secreted nucleobindin-2 inhibits 3T3-L1 adipocyte differentiation.
Protein and peptide letters 2012;19(9):997-1004.
2012: Aya Osaki; Hiroyuki Shimizu; Yoko Suzuki; Noriko Ishizuka; Masatomo Mori; Shuji Inoue
Enhanced expression of nesfatin/nucleobindin-2 in white adipose tissue of ventromedial hypothalamus-lesioned rats.
Neuroscience letters 2012;521(1):46-51.
2012: Emi Ishida; Ikuo Kato; Koshi Hashimoto; Shuichi Okada; Tetsurou Satoh; Hiroyuki Shimizu; Masanobu Yamada; Masatomo Mori
Nesfatin-1 induces the phosphorylation levels of cAMP response element-binding protein for intracellular signaling in a neural cell line.
PloS one 2012;7(12):e50918.
2011: Hiroyuki Shimizu; Kenju Shimomura; Takafumi Tsuchiya; Yasuyo Ariyama; Mikiko Kishi; Shinsuke Oh-I; Ken-Ichi Ohtani; Shuichi Okada; Masatomo Mori
Glucagon plays an important role in the modification of insulin secretion by leptin.
Islets 2011;3(4):150-4.
2011: Takafumi Tsuchiya; Shuichi Okada; Hiroyuki Shimizu; Masatomo Mori
Cumulative effects of genetic risk variants on the development of common atherosclerosis.
Expert review of cardiovascular therapy 2011;9(3):295-8.
2010: T Ando; Shuichi Okada; Y Niijima; Koshi Hashimoto; Hiroyuki Shimizu; Takafumi Tsuchiya; Masanobu Yamada; K Ohshima; Masatomo Mori; K Ono
Impaired glucose tolerance, but not impaired fasting glucose, is a risk factor for early-stage atherosclerosis.
Diabetic medicine : a journal of the British Diabetic Association 2010;27(12):1430-5.
2010: Takafumi Tsuchiya; Hiroyuki Shimizu; Masanobu Yamada; Aya Osaki; Shinsuke Oh-I; Yasuyo Ariyama; Hiroki Takahashi; Shuichi Okada; Koshi Hashimoto; Tetsurou Satoh; Masaaki Kojima; Masatomo Mori
Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males.
Clinical endocrinology 2010;73(4):484-90.
2010: Masanobu Yamada; Keishi Horiguchi; Ryohei Umezawa; Koshi Hashimoto; Tetsurou Satoh; Atsushi Ozawa; Nobuyuki Shibusawa; Tsuyoshi Monden; Shuichi Okada; Hiroyuki Shimizu; Masatomo Mori
Troglitazone, a ligand of peroxisome proliferator-activated receptor-{gamma}, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway: isolation and characterization of the human NUCB2 gene.
Endocrinology 2010;151(6):2494-503.
2010: Miki Tuboi; Takafumi Tsuchiya; Ryo Taguchi; Yoshiki Tanaka; Yasuki Iwasaki; Koshi Hashimoto; Satoru Kakizaki; Shuichi Okada; Hiroyuki Shimizu; Masatomo Mori
[Insulin allergy whose local/systemic reactions were reduced by desensitization with long-acting insulin analog, glargine].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2010;99(1):133-5.
2009: Hiroyuki Shimizu; Yutaka Uehara; Aya Ohsaki; Shuichi Okada; Masatomo Mori
Administration time difference of candesartin effect on albuminuria in type 2 diabetic patients.
Hypertension research : official journal of the Japanese Society of Hypertension 2009;32(6):527-8.
2009: Hiroyuki Shimizu; Aya Ohsaki; Shinsuke Oh-I; Shuichi Okada; Masatomo Mori
A new anorexigenic protein, nesfatin-1.
Peptides 2009;30(5):995-8.
2009: Hiroyuki Shimizu; Shinsuke Oh-I; Koshi Hashimoto; M Nakata; S Yamamoto; N Yoshida; H Eguchi; I Kato; Kyoko Inoue; Teturou Satoh; Shuichi Okada; Masanobu Yamada; T Yada; Masatomo Mori
Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism.
Endocrinology 2009;150(2):662-71.
2009: Hiroyuki Shimizu; Shinsuke Oh-I; Shuichi Okada; Masatomo Mori
Nesfatin-1: an overview and future clinical application.
Endocrine journal 2009;56(4):537-43.
2008: Yasuyo Ariyama; Yoshito Tanaka; Hiroyuki Shimizu; Kenju Shimomura; Shuichi Okada; Tsugumichi Saito; Eijiro Yamada; Seiichi Oyadomari; Masatomo Mori; Masatomo Mori
The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis.
Metabolism: clinical and experimental 2008;57(12):1625-35.
2008: Hiroyuki Shimizu; Yutaka Uehara; Shuichi Okada; Masatomo Mori
Contribution of fasting and postprandial hyperglycemia to hemoglobin A1c in insulin-treated Japanese diabetic patients.
Endocrine journal 2008;55(4):753-6.
2008: Takayuki Saitoh; Takafumi Matsushima; Hiroyuki Shimizu; Yohei Osaki; Arito Yamane; Hiroyuki Irisawa; Akihiko Yokohama; Hideki Uchiumi; Hiroshi Handa; Norifumi Tsukamoto; Masamitsu Karasawa; Yoshihisa Nojima; Hirokazu Murakami
[Successful treatment of azole-refractory Candida guilliermondii fungemia with a combination therapy of micafungin and liposomal amphotericin B].
[Rinshō ketsueki] The Japanese journal of clinical hematology 2008;49(2):94-8.
2008: Mitsuhiko Umahara; Shuichi Okada; Eijiro Yamada; Tsugumichi Saito; Kihachi Ohshima; Koshi Hashimoto; Masanobu Yamada; Hiroyuki Shimizu; Jeffrey Pessin; Masatomo Mori
Tyrosine phosphorylation of Munc18c regulates platelet-derived growth factor-stimulated glucose transporter 4 translocation in 3T3L1 adipocytes.
Endocrinology 2008;149(1):40-9.
2007: Yasuyo Ariyama; Hiroyuki Shimizu; Tetsurou Satoh; Takafumi Tsuchiya; Shuichi Okada; Seiichi Oyadomari; Masatomo Mori; Masatomo Mori
Chop-deficient mice showed increased adiposity but no glucose intolerance.
Obesity (Silver Spring, Md.) 2007;15(7):1647-56.
2007: Shuichi Okada; Kihachi Ohshima; Yutaka Uehara; Hiroyuki Shimizu; Koshi Hashimoto; Masanobu Yamada; Masatomo Mori
Synip phosphorylation is required for insulin-stimulated Glut4 translocation.
Biochemical and biophysical research communications 2007;356(1):102-6.
2007: Hiroyuki Shimizu; Kinji Inoue; Masatomo Mori
The leptin-dependent and -independent melanocortin signaling system: regulation of feeding and energy expenditure.
The Journal of endocrinology 2007;193(1):1-9.
2007: Hiroyuki Shimizu; Shinsuke Oh-I; Shuichi Okada; Masatomo Mori
Leptin resistance and obesity.
Endocrine journal 2007;54(1):17-26.
2006: Hiroyuki Shimizu; Shinsuke I Oh; Masatomo Mori
[Brain-adipose axis and leptin resistance].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():110-5.
2006: Shinsuke Oh-I; Hiroyuki Shimizu; Tetsurou Satoh; Shuichi Okada; Sachika Adachi; Kinji Inoue; Hiroshi Eguchi; Masanori Yamamoto; Toshihiro Imaki; Koushi Hashimoto; Takafumi Tsuchiya; Tsuyoshi Monden; Keishi Horiguchi; Masanobu Yamada; Masatomo Mori
Identification of nesfatin-1 as a satiety molecule in the hypothalamus.
Nature 2006;443(7112):709-12.
2006: Hiroyuki Shimizu; Shinsuke Oh-I; Takafumi Tsuchiya; K-I Ohtani; Shuichi Okada; Masatomo Mori
Pioglitazone increases circulating adiponectin levels and subsequently reduces TNF-alpha levels in Type 2 diabetic patients: a randomized study.
Diabetic medicine : a journal of the British Diabetic Association 2006;23(3):253-7.
2005: Hiroyuki Shimizu; Shinsuke Oh-I; Shuichi Okada; Masatomo Mori
Inhibition of appetite by nasal leptin administration in rats.
International journal of obesity (2005) 2005;29(7):858-63.
2005: Shinsuke Oh-I; Hiroyuki Shimizu; Tetsurou Sato; Yutaka Uehara; Shuichi Okada; Masatomo Mori
Molecular mechanisms associated with leptin resistance: n-3 polyunsaturated fatty acids induce alterations in the tight junction of the brain.
Cell metabolism 2005;1(5):331-41.
2005: Eijiro Yamada; Shuichi Okada; Tsugumichi Saito; Kihachi Ohshima; Minoru Sato; Takafumi Tsuchiya; Yutaka Uehara; Hiroyuki Shimizu; Masatomo Mori
Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles.
The Journal of cell biology 2005;168(6):921-8.
2005: Hiroyuki Shimizu; Masatomo Mori
The brain-adipose axis: a review of involvement of molecules.
Nutritional neuroscience 2005;8(1):7-20.
2004: Mayumi Negishi; Hiroyuki Shimizu; Shuichi Okada; Atsushi Kuwabara; Fumikazu Okajima; Masatomo Mori
9HODE stimulates cell proliferation and extracellular matrix synthesis in human mesangial cells via PPARgamma.
Experimental biology and medicine (Maywood, N.J.) 2004;229(10):1053-60.
2004: Kenju Shimomura; Hiroyuki Shimizu; Mizuho Ikeda; Shuichi Okada; Masafumi Kakei; Shigeji Matsumoto; Masatomo Mori
Fenofibrate, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2 close KATP channels and induce insulin secretion.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1273-80.
2004: Tsugumichi Saito; Shuichi Okada; Kihachi Ohshima; Eijiro Yamada; Minoru Sato; Yutaka Uehara; Hiroyuki Shimizu; Jeffrey Pessin; Masatomo Mori
Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF.
Endocrinology 2004;145(9):4232-43.
2003: Ryohei Umezawa; Koshi Hashimoto; Hideo Tsukagoshi; Tatsuya Higuchi; Teturou Satoh; Masanobu Yamada; Hiroyuki Shimizu; Masatomo Mori
[Hypothalamic hypogonadism associated with GRH and CRH deficiencies].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2003;92(12):2420-2.
2003: Miki Koizumi; Hiroyuki Shimizu; Kenju Shimomura; Shinsuke Oh-I; Yasuyo Tomita; Tomohiro Kudo; Ken-Ichi Iizuka; Masatomo Mori
Relationship between hyperinsulinemia and pulse wave velocity in moderately hyperglycemic patients.
Diabetes research and clinical practice 2003;62(1):17-21.
2003: Tsugumichi Saito; Shuichi Okada; Eijiro Yamada; Kihachi Ohshima; Hiroyuki Shimizu; Kenju Shimomura; Minoru Sato; Jeffrey Pessin; Masatomo Mori
Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cell.
The Journal of biological chemistry 2003;278(38):36718-25.
2003: Takahumi Tsuchiya; Hiroyuki Shimizu; Kenju Shimomura; Masatomo Mori
Troglitazone inhibits isolated cell proliferation, and induces apoptosis in isolated rat mesangial cells.
American journal of nephrology 2003;23(4):222-8.
2002: Yoshimi Takahashi; Jun Ninomiya; Jun Horiguchi; Hiroyuki Shimizu; Minoru Sato; Yukio Koibuchi; Takashi Yoshida; Miho Yoshida; Daisuke Takata; Hiroki Odawara; Takao Yokoe; Yuichi Iino; Yasuo Morishita; Masatomo Mori
Primary amenorrhea accompanied by adrenal adenoma: start of menarche soon after tumor resection.
Internal medicine (Tokyo, Japan) 2002;41(11):972-6.
2002: Kenju Shimomura; Hiroyuki Shimizu; Takahumi Tsuchiya; Yumiko Abe; Yutaka Uehara; Masatomo Mori
Is leptin a key factor which develops obesity by ovariectomy?
Endocrine journal 2002;49(4):417-23.
2002: Hiroyuki Shimizu; Kenju Shimomura; Mayumi Negishi; Miki Masunaga; Yutaka Uehara; Noriyuki Sato; Yohnosuke Shimomura; Kikuo Kasai; Masatomo Mori
Circulating concentrations of soluble leptin receptor: influence of menstrual cycle and diet therapy.
Nutrition (Burbank, Los Angeles County, Calif.) 2002;18(4):309-12.
2002: Teturou Satoh; Mitsuo Toyoda; Hideki Hoshino; Tsuyoshi Monden; Masanobu Yamada; Hiroyuki Shimizu; Kaoru Miyamoto; Masatomo Mori; Masanabu Yamada; Matsumoto Mori
Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells.
Oncogene 2002;21(14):2171-80.
2001: H Takahashi; M Oh-Ishi; Hiroyuki Shimizu; Masatomo Mori
Detection and identification of subcutaneous adipose tissue protein related to obesity in New Zealand obese mouse.
Endocrine journal 2001;48(2):205-11.
2001: Hiroyuki Shimizu; Masatomo Mori
[Role of leptin and its receptor in the regulation of appetite and body fat].
Nihon rinsho. Japanese journal of clinical medicine 2001;59(3):421-6.
2000: Hiroyuki Shimizu; K Ohtani; Y Kato; Masatomo Mori
Interleukin-6 increases insulin secretion and preproinsulin mRNA expression via Ca2+-dependent mechanism.
The Journal of endocrinology 2000;166(1):121-6.
2000: Hiroyuki Shimizu; Fumikazu Okajima; Takao Kimura; K Ohtani; Takahumi Tsuchiya; H Takahashi; Atsushi Kuwabara; Hideaki Tomura; Ken Sato; Masatomo Mori
Sphingosine 1-phosphate stimulates insulin secretion in HIT-T 15 cells and mouse islets.
Endocrine journal 2000;47(3):261-9.
2000: Hiroyuki Shimizu; K I Ohtani; T Tsuchiya; N Sato; Y Tanaka; H Takahashi; Y Uehara; T Inukai; Masatomo Mori
Aldose reductase mRNA expression is associated with rapid development of diabetic microangiopathy in Japanese Type 2 diabetic (T2DM) patients.
Diabetes, nutrition & metabolism 2000;13(2):75-9.
1999: Ken Sato; N Sato; Hiroyuki Shimizu; T Tsutiya; H Takahashi; S Kakizaki; H Takayama; H Takagi; Masatomo Mori
Faropenem enhances superoxide anion production by human neutrophils in vitro.
The Journal of antimicrobial chemotherapy 1999;44(3):337-41.
1998: Hiroyuki Shimizu; S Kakizaki; T Tsuchiya; T Nagamine; H Takagi; H Takayama; Isao Kobayashi; Masatomo Mori
An increase of circulating leptin in patients with liver cirrhosis.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1998;22(12):1234-8.
1998: Hiroyuki Shimizu; Takahumi Tsuchiya; N Sato; Y Shimomura; Isao Kobayashi; Masatomo Mori
Troglitazone reduces plasma leptin concentration but increases hunger in NIDDM patients.
Diabetes care 1998;21(9):1470-4.
1998: K Kashima; N Sato; Ken Sato; Hiroyuki Shimizu; Masatomo Mori
Effect of epalrestat, an aldose reductase inhibitor, on the generation of oxygen-derived free radicals in neutrophils from streptozotocin-induced diabetic rats.
Endocrinology 1998;139(8):3404-8.
1998: Y Uehara; Hiroyuki Shimizu; KI Ohtani; N Sato; Masatomo Mori
Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin.
Diabetes 1998;47(6):890-3.
1998: Hiroyuki Shimizu; KI Ohtani; Y Uehara; Y Abe; H Takahashi; T Tsuchiya; N Sato; Y Ibuki; Masatomo Mori
Orchiectomy and response to testosterone in the development of obesity in young Otsuka-Long-Evans-Tokushima Fatty (OLETF) rats.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1998;22(4):318-24.
1998: K Ohtani; Hiroyuki Shimizu; Y Kato; Masatomo Mori
Identification and characterization of a glucose-responsiveness region upstream of human insulin gene in transfected HIT-T 15 cells.
Biochemical and biophysical research communications 1998;242(2):446-51.
1998: N Sato; Hiroyuki Shimizu; Masatomo Mori
[Myeloperoxidase].
Nihon rinsho. Japanese journal of clinical medicine 1998;56 Suppl 3():246-50.
1998: K I Ohtani; Hiroyuki Shimizu; N Sato; Masatomo Mori
Troglitazone (CS-045) inhibits beta-cell proliferation rate following stimulation of insulin secretion in HIT-T 15 cells.
Endocrinology 1998;139(1):172-8.
1997: Hiroyuki Shimizu; Y Shimomura; Y Nakanishi; T Futawatari; K Ohtani; N Sato; Masatomo Mori
Estrogen increases in vivo leptin production in rats and human subjects.
The Journal of endocrinology 1997;154(2):285-92.
1997: Hiroyuki Shimizu; Y Shimomura; R Hayashi; KI Ohtani; N Sato; T Futawatari; Masatomo Mori
Serum leptin concentration is associated with total body fat mass, but not abdominal fat distribution.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1997;21(7):536-41.
1997: N Sato; K Kashima; Y Uehara; K Ohtani; Hiroyuki Shimizu; Masatomo Mori
Epalrestat, an aldose reductase inhibitor, improves an impaired generation of oxygen-derived free radicals by neutrophils from poorly controlled NIDDM patients.
Diabetes care 1997;20(6):995-8.
1997: Hiroyuki Shimizu; K Ohtani; T Tsuchiya; H Takahashi; Y Uehara; N Sato; Masatomo Mori
Leptin stimulates insulin secretion and synthesis in HIT-T 15 cells.
Peptides 1997;18(8):1263-6.
1997: N Sato; K Kashima; Yuji Tanaka; Hiroyuki Shimizu; Masatomo Mori
Effect of granulocyte-colony stimulating factor on generation of oxygen-derived free radicals and myeloperoxidase activity in neutrophils from poorly controlled NIDDM patients.
Diabetes 1997;46(1):133-7.
1996: N Sato; K Kashima; Hiroyuki Shimizu; Yoshiharu Shimomura; Masatomo Mori
Hypertonic glucose impairs glucose-induced increases in cytosol Ca2+ concentration and insulin secretion by HIT-T 15 cells.
Cell calcium 1996;20(3):273-8.
1996: M Negishi; Hiroyuki Shimizu; K Ohtani; Masatomo Mori
Acarbose partially prevents the development of diabetes mellitus by multiple low-dose streptozotocin administration.
Diabetes research and clinical practice 1996;33(1):15-9.
1996: Hiroyuki Shimizu; K Ohtani; Y Kato; Y Tanaka; Masatomo Mori
Withdrawal of [corrected] estrogen increases hypothalamic neuropeptide Y (NPY) mRNA expression in ovariectomized obese rat .
Neuroscience letters 1996;204(1-2):81-4.
1996: A Fukatsu; N Sato; Hiroyuki Shimizu
50-mile walking race suppresses neutrophil bactericidal function by inducing increases in cortisol and ketone bodies.
Life sciences 1996;58(25):2337-43.
1995: Hiroyuki Shimizu; K Ohtani; Y Tanaka; A Fukatsu; Y Uehara; N Sato; Masatomo Mori
Increased plasma thrombin-antithrombin III complex levels in non-insulin dependent diabetic patients with albuminuria are reduced by ethyl icosapentatenoate.
Thrombosis and haemostasis 1995;74(5):1231-4.
1995: Hiroyuki Shimizu; Y Uehara; N Sato; Masatomo Mori; Yoshiharu Shimomura
The pH dependence of interleukin-1 beta effects on insulin secretion in HIT cells.
Journal of endocrinological investigation 1995;18(8):603-7.
1995: Hiroyuki Shimizu
[Role of cytokines in regulation of food intake and appetite].
Nihon rinsho. Japanese journal of clinical medicine 1995;53 Suppl():58-63.
1995: Hiroyuki Shimizu; K Ohtani; Y Tanaka; N Sato; Masatomo Mori; Y Shimomura
Long-term effect of eicosapentaenoic acid ethyl (EPA-E) on albuminuria of non-insulin dependent diabetic patients.
Diabetes research and clinical practice 1995;28(1):35-40.
1995: Y Tanaka; Hiroyuki Shimizu; N Sato; Masatomo Mori; Yoshiharu Shimomura
Involvement of spontaneous nitric oxide production in the diabetogenic action of streptozotocin.
Pharmacology 1995;50(2):69-73.
1995: Hiroyuki Shimizu; Y Tanaka; N Sato; Masatomo Mori
Alpha-melanocyte-stimulating hormone (MSH) inhibits insulin secretion in HIT-T 15 cells.
Peptides 1995;16(4):605-8.
1993: Hiroyuki Shimizu; G A Bray
Effects of castration, estrogen replacement and estrus cycle on monoamine metabolism in the nucleus accumbens, measured by microdialysis.
Brain research 1993;621(2):200-6.
1993: Y Uehara; Hiroyuki Shimizu; N Sato; Y S Mura; Masatomo Mori
The dipeptide Lys-Pro attenuates interleukin-1 beta-induced anorexia.
Peptides 1993;14(2):175-8.
1993: N Sato; Hiroyuki Shimizu
Granulocyte-colony stimulating factor improves an impaired bactericidal function in neutrophils from STZ-induced diabetic rats.
Diabetes 1993;42(3):470-3.
1993: M Oohara; M Negishi; Hiroyuki Shimizu; N Sato; Masatomo Mori
Alpha-melanocyte stimulating hormone (MSH) antagonizes the anorexia by corticotropin releasing factor (CRF).
Life sciences 1993;53(19):1473-7.
1993: N Sato; K Kashima; Hiroyuki Shimizu; Y Uehara; Yoshiharu Shimomura; Masatomo Mori
Hypertonic glucose inhibits the production of oxygen-derived free radicals by rat neutrophils.
Life sciences 1993;52(18):1481-6.
1992: Hiroyuki Shimizu; M Negishi; Y Shimomura; Masatomo Mori
Changes in urinary retinol binding protein excretion and other indices of renal tubular damage in patients with non-insulin dependent diabetes.
Diabetes research and clinical practice 1992;18(3):207-10.
1992: Hiroyuki Shimizu; Y Uehara; N Sato; Yoshiharu Shimomura; Masatomo Mori; Isao Kobayashi
Dexamethasone attenuates altered insulin secretion elicited by interleukin-1 beta in HIT cells.
European journal of pharmacology 1992;222(2-3):279-82.
1992: Hiroyuki Shimizu; S Tanaka; Masatomo Mori
Adrenalectomy enhances the susceptibility of pancreatic islets to interleukin-1 beta: immunohistochemical study.
Endocrinologia japonica 1992;39(5):485-90.
1992: Y Uehara; Hiroyuki Shimizu; N Sato; Y Tanaka; Yoshiharu Shimomura; Masatomo Mori
Carboxyl-terminal tripeptide of alpha-melanocyte-stimulating hormone antagonizes interleukin-1-induced anorexia.
European journal of pharmacology 1992;220(2-3):119-22.
1992: Hiroyuki Shimizu; M Negishi; Y Uehara; Yoshiharu Shimomura; Masatomo Mori; Isao Kobayashi
Interleukin 1 pretreatment reduces the insulin response to glucose in chronic sucrose-fed rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1992;200(4):514-7.
1992: N Sato; Hiroyuki Shimizu; K Suwa; Yoshiharu Shimomura; Isao Kobayashi; Masatomo Mori
MPO activity and generation of active O2 species in leukocytes from poorly controlled diabetic patients.
Diabetes care 1992;15(8):1050-2.
1992: Yoshiharu Shimomura; S Saito; Takeaki Nagamine; Hiroyuki Shimizu; M Takahashi; Y Uehara; N Sato; M Negishi; S Yamada; Isao Kobayashi
Feeding behavior and ambulatory activity in rats with D-galactosamine-induced hepatic failure.
Physiology & behavior 1992;51(5):1029-33.
1992: Hiroyuki Shimizu; Yoshiharu Shimomura; N Sato; Y Uehara; Isao Kobayashi
Colonic temperature was not changed in the development of obesity after ovariectomy.
Experimental and clinical endocrinology 1992;99(2):99-101.
1992: Hiroyuki Shimizu; N Sato; Y Uehara; Yoshiharu Shimomura
Hypothermia in insulin-treated obese rats.
Experimental and clinical endocrinology 1992;99(2):96-8.
1992: Hiroyuki Shimizu; Y Uehara; M Negishi; Yoshiharu Shimomura; M Takahashi; A Fukatsu; S Takahashi; Y Tanaka; K Kashima; Isao Kobayashi
Altered monoamine metabolism in the hypothalamus of the genetically obese yellow (Ay/a) mouse.
Experimental and clinical endocrinology 1992;99(1):45-8.
1992: Hiroyuki Shimizu; Y Uehara; Masatomo Mori
Probucol attenuates a reduction in serum immunoreactive insulin levels by interleukin in adrenalectomized rats.
Pharmacology 1992;44(6):344-8.
1992: Yoshiharu Shimomura; T Inukai; S Kuwabara; Hiroyuki Shimizu; M Takahashi; N Sato; Y Uehara; Y Tanaka; Isao Kobayashi
Both cyclooxygenase and lipoxygenase inhibitor partially restore the anorexia by interleukin-1 beta.
Life sciences 1992;51(18):1419-26.
1992: N Sato; Hiroyuki Shimizu; Yoshiharu Shimomura; Y Uehara; M Takahashi; Isao Kobayashi
Reduced ability of neutrophils to produce active oxygen species in streptozotocin-induced diabetic rats.
Experimental and clinical endocrinology 1992;99(1):31-3.
1992: N Sato; Hiroyuki Shimizu; Yoshiharu Shimomura; K Suwa; Masatomo Mori; Isao Kobayashi
Mechanism of inhibitory action of ketone bodies on the production of reactive oxygen intermediates (ROIS) by polymorphonuclear leukocytes.
Life sciences 1992;51(2):113-8.
1991: Yoshiharu Shimomura; T Inukai; Atsushi Kuwabara; Hiroyuki Shimizu; N Sato; Y Uehara; Isao Kobayashi; S Kobayashi
Enhanced sensitivity to anorexia and consumption of drinking water induced by interleukin-1 beta in obese yellow mice.
European journal of pharmacology 1991;209(1-2):15-8.
1991: Hiroyuki Shimizu
Alteration in hypothalamic monoamine metabolism of freely moving diabetic rat.
Neuroscience letters 1991;131(2):225-7.
1991: Y Uehara; Hiroyuki Shimizu; N Sato; Yoshiharu Shimomura; Masatomo Mori; Isao Kobayashi
Probucol partially prevents development of diabetes in NOD mice.
Diabetes research (Edinburgh, Scotland) 1991;17(3):131-4.
1991: Y Uehara; Hiroyuki Shimizu; Y Shimomura; M Negishi; A Fukatsu; K Kashima; Y Tanaka; Isao Kobayashi
Central administration of Lys-D-Pro-Thr, an interleukin-1 beta 193-195 analogue, stimulates feeding in rats.
Neuropeptides 1991;19(1):9-11.
1991: Hiroyuki Shimizu; Y Uehara; Yoshiharu Shimomura; M Negishi; Isao Kobayashi; S Kobayashi
Involvement of interleukin-1 in the inhibition of in vivo insulin release: possible role of adrenal glands.
Journal of endocrinological investigation 1991;14(5):401-4.
1991: Hiroyuki Shimizu; Y Uehara; Yoshiharu Shimomura; Isao Kobayashi
Central administration of ibuprofen failed to block the anorexia induced by interleukin-1.
European journal of pharmacology 1991;195(2):281-4.
1991: Hiroyuki Shimizu; Yoshiharu Shimomura; M Takahashi; Y Uehara; A Fukatsu; N Sato
Altered ambulatory activity and related brain monoamine metabolism in genetically obese Zucker rats.
Experimental and clinical endocrinology 1991;97(1):39-44.
1991: Hiroyuki Shimizu; Y Uehara; Yoshiharu Shimomura; Y Tanaka; Isao Kobayashi
Probucol attenuated hyperglycemia in multiple low-dose streptozotocin-induced diabetic mice.
Life sciences 1991;49(18):1331-8.
1991: N Sato; Hiroyuki Shimizu; Yoshiharu Shimomura; Y Uehara; M Takahashi; M Negishi
Sucrose feeding at weaning alters the preference for sucrose in adolescence.
Experimental and clinical endocrinology 1991;98(3):201-6.
1990: Hiroyuki Shimizu; Y Uehara; Yoshiharu Shimomura; M Negishi; A Fukatsu
Inhibited insulin secretion by recombinant human interleukin-1 beta in adrenalectomized rats: involvement of prostaglandin.
Biochemical and biophysical research communications 1990;173(3):1280-6.
1990: Yoshiharu Shimomura; Hiroyuki Shimizu; M Takahashi; Y Uehara; M Negishi; Isao Kobayashi; S Kobayashi
Different effects of insulin administration time in streptozotocin-induced diabetic rats.
Experimental and clinical endocrinology 1990;96(3):296-300.
1990: Y Uehara; Hiroyuki Shimizu; Yoshiharu Shimomura; M Negishi; Isao Kobayashi; S Kobayashi
Effects of recombinant human interleukins on food intake of previously food-deprived rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1990;195(2):197-201.
1990: Y Uehara; Hiroyuki Shimizu; Y Shimomura; Isao Kobayashi; S Kobayashi
Rat brain natriuretic peptide (BNP) reduces water intake following dehydration.
Neuropeptides 1990;17(2):107-10.
1990: Hiroyuki Shimizu; Yoshiharu Shimomura; Y Uehara; Isao Kobayashi; S Kobayashi
Involvement of sex hormone in body weight gain by selective D2 receptor antagonist sulpiride.
Experimental and clinical endocrinology 1990;96(1):25-9.
1990: Yoshiharu Shimomura; Hiroyuki Shimizu; M Takahashi; Y Uehara; Isao Kobayashi; S Kobayashi
Corticosterone and ambulatory activity in the (ovariectomy and adrenalectomy) rats.
Experimental and clinical endocrinology 1990;95(3):281-5.
1990: Yoshiharu Shimomura; Hiroyuki Shimizu; M Takahashi; Y Uehara; Isao Kobayashi; S Kobayashi
Ambulatory activity and dopamine turnover in streptozotocin-induced diabetic rats.
Experimental and clinical endocrinology 1990;95(3):385-8.
1990: Yoshiharu Shimomura; Hiroyuki Shimizu; M Takahashi; N Sato; Y Uehara; M Negishi; Isao Kobayashi; S Kobayashi
Ambulatory activity in streptozotocin-induced diabetic rats.
Physiology & behavior 1990;47(6):1153-5.
1990: Yoshiharu Shimomura; M Takahashi; Hiroyuki Shimizu; N Sato; Y Uehara; M Negishi; T Inukai; Isao Kobayashi; S Kobayashi
Abnormal feeding behavior and insulin replacement in STZ-induced diabetic rats.
Physiology & behavior 1990;47(4):731-4.
1990: Hiroyuki Shimizu; Yoshiharu Shimomura; M Takahashi; Isao Kobayashi; S Kobayashi
Dopamine receptor in the streptozotocin-induced diabetic rats.
Experimental and clinical endocrinology 1990;95(2):263-6.
1990: Hiroyuki Shimizu; M Negishi; M Takahashi; Yoshiharu Shimomura; Y Uehara; Isao Kobayashi; S Kobayashi
Dexamethasone suppressible hypergonadotropism in an adolescent patient with Prader-Willi syndrome.
Endocrinologia japonica 1990;37(1):165-9.
1990: Y Shimommura; Hiroyuki Shimizu; M Takahashi; Y Uehara; M Negishi; N Sato; T Inukai; Isao Kobayashi; S Kobayashi
Effects of peripheral administration of recombinant human interleukin-1 beta on feeding behavior of the rat.
Life sciences 1990;47(24):2185-92.
1989: Yoshiharu Shimomura; Hiroyuki Shimizu; Isao Kobayashi; S Kobayashi
Importance of feeding time in pair-fed, ovariectomized rats.
Physiology & behavior 1989;45(6):1197-200.
1989: Hiroyuki Shimizu; Yoshiharu Shimomura; M Negishi; Isao Kobayashi; S Kobayashi
Dynorphin A (1-13), microinjected into the preoptic area, stimulates water intake in rats.
Life sciences 1989;45(1):25-30.
1988: Yoshiharu Shimomura; Hiroyuki Shimizu; M Takahashi; N Sato; Y Uehara; K Suwa; Isao Kobayashi; S Tadokoro; S Kobayashi
Changes in ambulatory activity and dopamine turnover in streptozotocin-induced diabetic rats.
Endocrinology 1988;123(6):2621-5.