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Kenji Shimizu

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Satoru Itani; Sachio Ito; Toshiyuki Kunisada; Yuki Morimoto; Mamoru Ouchida; Tsuyoshi Sasaki; Kenji Shimizu; Shinsuke Sugihara; Aki Yoshida; Toshifumi Ozaki
MicroRNA-21 correlates with tumorigenesis in malignant peripheral nerve sheath tumor (MPNST) via programmed cell death protein 4 (PDCD4).
Takeshi Tomoda; Kazuhide Yamamoto; Sayo Kobayashi; Koji Miyahara; Shinichiro Nakamura; Kazuhiro Nouso; Hideki Onishi; Mamoru Ouchida; Akiko Sakai; Kenji Shimizu
Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study.
Mamoru Ouchida; Seiji Tamaru; Hiroko Hanafusa; Sachio Ito; Yoshimi Jitsumori; Hirotaka Kanzaki; Kenji Shimizu
Novel direct targets of miR-19a identified in breast cancer cells by a quantitative proteomic approach.

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All Publications

2012: Satoru Itani; Sachio Ito; Toshiyuki Kunisada; Yuki Morimoto; Mamoru Ouchida; Tsuyoshi Sasaki; Kenji Shimizu; Shinsuke Sugihara; Aki Yoshida; Toshifumi Ozaki
MicroRNA-21 correlates with tumorigenesis in malignant peripheral nerve sheath tumor (MPNST) via programmed cell death protein 4 (PDCD4).
Journal of cancer research and clinical oncology 2012;138(9):1501-9.
2012: Takeshi Tomoda; Kazuhide Yamamoto; Sayo Kobayashi; Koji Miyahara; Shinichiro Nakamura; Kazuhiro Nouso; Hideki Onishi; Mamoru Ouchida; Akiko Sakai; Kenji Shimizu
Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study.
Journal of gastroenterology and hepatology 2012;27(4):797-804.
2012: Mamoru Ouchida; Seiji Tamaru; Hiroko Hanafusa; Sachio Ito; Yoshimi Jitsumori; Hirotaka Kanzaki; Kenji Shimizu
Novel direct targets of miR-19a identified in breast cancer cells by a quantitative proteomic approach.
PloS one 2012;7(8):e44095.
2011: Hirotaka Kanzaki; Hiroko Hanafusa; Sachio Ito; Yoshimi Jitsumori; Kenji Shimizu; Seiji Tamaru; Mamoru Ouchida
Identification of direct targets for the miR-17-92 cluster by proteomic analysis.
Proteomics 2011;11(17):3531-9.
2011: Teruhisa Sonoyama; Akiko Sakai; Yuichiro Mita; Yukiko Yasuda; Hirofumi Kawamoto; Takahito Yagi; Masao Yoshioka; Tetsushige Mimura; Kei Nakachi; Mamoru Ouchida; Kazuhide Yamamoto; Kenji Shimizu
TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers.
Molecular medicine reports 2011;4(3):489-95.
2011: Masamichi Tanaka; Kazufumi Nakamura; Kengo Fukushima Kusano; Hiroshi Morita; Keiko Ohta-Ogo; Daiji Miura; Aya Miura; Koji Nakagawa; Takeshi Tada; Masato Murakami; Nobuhiro Nishii; Satoshi Nagase; Yoshiki Hata; Kunihisa Kohno; Mamoru Ouchida; Kenji Shimizu; Chikao Yutani; Tohru Ohe; Hiroshi Ito
Elevated oxidative stress is associated with ventricular fibrillation episodes in patients with Brugada-type electrocardiogram without SCN5A mutation.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2011;20(1):e37-42.
2010: Beyhan Cengiz; Esra Gunduz; Mehmet Gunduz; Levent Beder; Ryo Tamamura; Cahit Bagci; Noboru Yamanaka; Kenji Shimizu; Hitoshi Nagatsuka
Tumor-specific mutation and downregulation of ING5 detected in oral squamous cell carcinoma.
International journal of cancer. Journal international du cancer 2010;127(9):2088-94.
2010: Mahmoud A L Sheikh Ali; Mehmet Gunduz; Esra Gunduz; Ryo Tamamura; Levent Beder; Naoki Katase; Omer Faruk Hatipoglu; Kunihiro Fukushima; Noboru Yamanaka; Kenji Shimizu; Hitoshi Nagatsuka
Expression and mutation analysis of her2 in head and neck squamous cell carcinoma.
Cancer investigation 2010;28(5):495-500.
2010: Yuichiro Mita; Yukiko Yasuda; Akiko Sakai; Hiromasa Yamamoto; Shinichi Toyooka; Mehmet Gunduz; Shunsuke Tanabe; Yoshio Naomoto; Mamoru Ouchida; Kenji Shimizu
Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers.
Journal of cancer research and clinical oncology 2010;136(2):249-59.
2010: Hiaki Sato; Takashi Oka; Yoko Shinnou; Takami Kondo; Kana Washio; Masayuki Takano; Katsuyoshi Takata; Toshiaki Morito; Xingang Huang; Maiko Tamura; Yuta Kitamura; Nobuya Ohara; Mamoru Ouchida; Koichi Ohshima; Kenji Shimizu; Mitsune Tanimoto; Kiyoshi Takahashi; Masao Matsuoka; Atae Utsunomiya; Tadashi Yoshino
Multi-step aberrant CpG island hyper-methylation is associated with the progression of adult T-cell leukemia/lymphoma.
The American journal of pathology 2010;176(1):402-15.
2010: Naoki Katase; Mehmet Gunduz; Levent Beder; Esra Gunduz; Mahmoud Al Sheikh Ali; Ryo Tamamura; Kursat Oguz Yaykasli; Noboru Yamanaka; Kenji Shimizu; Hitoshi Nagatsuka
Frequent allelic loss of Dkk-1 locus (10q11.2) is related with low distant metastasis and better prognosis in head and neck squamous cell carcinomas.
Cancer investigation 2010;28(1):103-10.
2009: Jie Chen; Masami Watanabe; Peng Huang; Masakiyo Sakaguchi; Kazuhiko Ochiai; Yasutomo Nasu; Mamoru Ouchida; Nam-ho Huh; Kenji Shimizu; Yuji Kashiwakura; Haruki Kaku; Hiromi Kumon
REIC/Dkk-3 stable transfection reduces the malignant phenotype of mouse prostate cancer RM9 cells.
International journal of molecular medicine 2009;24(6):789-94.
2009: Takami Kondo; Takashi Oka; Hiaki Sato; Yoko Shinnou; Kana Washio; Masayuki Takano; Toshiaki Morito; Katsuyoshi Takata; Nobuya Ohara; Mamoru Ouchida; Kenji Shimizu; Tadashi Yoshino
Accumulation of aberrant CpG hypermethylation by Helicobacter pylori infection promotes development and progression of gastric MALT lymphoma.
International journal of oncology 2009;35(3):547-57.
2009: Kadir Demircan; Esra Gunduz; Mehmet Gunduz; Levent Beder; Satoshi Hirohata; Hitoshi Nagatsuka; Beyhan Cengiz; Mehmet Cilek; Noboru Yamanaka; Kenji Shimizu; Yoshifumi Ninomiya
Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer.
Head & neck 2009;31(6):793-801.
2009: Silvia Susana Borkosky; Mehmet Gunduz; Hitoshi Nagatsuka; Levent Beder; Esra Gunduz; Mahmoud A L Sheikh Ali; Andrea P Rodriguez; Mehmet Cilek; Susumu Tominaga; Noboru Yamanaka; Kenji Shimizu; Noriyuki Nagai
Frequent deletion of ING2 locus at 4q35.1 associates with advanced tumor stage in head and neck squamous cell carcinoma.
Journal of cancer research and clinical oncology 2009;135(5):703-13.
2009: Takafumi Kubo; Hiromasa Yamamoto; William W Lockwood; Ilse Valencia; Junichi Soh; Michael Peyton; Masaru Jida; Hiroki Otani; Tetsuya Fujii; Mamoru Ouchida; Nagio Takigawa; Katsuyuki Kiura; Kenji Shimizu; Hiroshi Date; John D Minna; Marileila Varella-Garcia; Wan L Lam; Adi F Gazdar; Shinichi Toyooka
MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors.
International journal of cancer. Journal international du cancer 2009;124(8):1778-84.
2009: Esra Gunduz; Mehmet Gunduz; Levent Beder; Hitoshi Nagatsuka; Kunihiro Fukushima; Recep Sutcu; Namik Delibas; Noboru Yamanaka; Kenji Shimizu; Noriyuki Nagai
Downregulation of TESTIN and its association with cancer history and a tendency toward poor survival in head and neck squamous cell carcinoma.
Archives of otolaryngology--head & neck surgery 2009;135(3):254-60.
2009: Mathieu Lefeuvre; Mehmet Gunduz; Hitoshi Nagatsuka; Esra Gunduz; Mahmoud Al Sheikh Ali; Levent Beder; Kunihiro Fukushima; Noboru Yamanaka; Kenji Shimizu; Noriyuki Nagai
Fine deletion analysis of 1p36 chromosomal region in oral squamous cell carcinomas.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2009;38(1):94-8.
2008: Davut Pehlivan; Esra Gunduz; Mehmet Gunduz; Hitoshi Nagatsuka; Levent Beder; Beyhan Cengiz; Rosario S Rivera; Kunihiro Fukushima; Sukru Palanduz; Sukru Ozturk; Noboru Yamanaka; Kenji Shimizu
Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas.
Journal of cancer research and clinical oncology 2008;134(12):1267-76.
2008: Kei Nanba; Shinichi Toyooka; Junichi Soh; Kazunori Tsukuda; Hiromasa Yamamoto; Akiko Sakai; Mamoru Ouchida; Naruyuki Kobayashi; Keitaro Matsuo; Norio Koide; Katsuyasu Kusaka; Kenji Shimizu; Hiroshi Date
The allelic distribution of a single nucleotide polymorphism in the PDCD5 gene locus of Japanese non-small cell lung cancer patients.
Molecular medicine reports 2008;1(5):667-71.
2008: Mahmoud A L Sheikh Ali; Mehmet Gunduz; Hitoshi Nagatsuka; Esra Gunduz; Beyhan Cengiz; Kunihiro Fukushima; Levent Beder; Kadir Demircan; Masae Fujii; Noboru Yamanaka; Kenji Shimizu; Reidar Grenman; Noriyuki Nagai
Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma.
Cancer science 2008;99(8):1589-94.
2008: Rosario Santos Rivera; Mehmet Gunduz; Hitoshi Nagatsuka; Esra Gunduz; Beyhan Cengiz; Kunihiro Fukushima; Levent Bekir Beder; Davut Pehlivan; Noboru Yamanaka; Kenji Shimizu; Noriyuki Nagai
Involvement of EphA2 in head and neck squamous cell carcinoma: mRNA expression, loss of heterozygosity and immunohistochemical studies.
Oncology reports 2008;19(5):1079-84.
2008: Mehmet Gunduz; Levent Beder; Esra Gunduz; Hitoshi Nagatsuka; Kunihiro Fukushima; Davut Pehlivan; Eren Cetin; Noboru Yamanaka; Kazunori Nishizaki; Kenji Shimizu; Noriyuki Nagai
Downregulation of ING3 mRNA expression predicts poor prognosis in head and neck cancer.
Cancer science 2008;99(3):531-8.
2008: Iori Ohmori; Mamoru Ouchida; Katsuhiro Kobayashi; Yoshimi Jitsumori; Takushi Inoue; Kenji Shimizu; Hideki Matsui; Yoko Ohtsuka; Yoshihiro Maegaki
Rasmussen encephalitis associated with SCN 1 A mutation.
Epilepsia 2008;49(3):521-6.
2008: Hirotaka Kanzaki; Mamoru Ouchida; Hiroko Hanafusa; Hiromasa Yamamoto; Hiromitsu Suzuki; Masaaki Yano; Motoi Aoe; Kazue Imai; Hiroshi Date; Kei Nakachi; Kenji Shimizu
The association between RAD18 Arg302Gln polymorphism and the risk of human non-small-cell lung cancer.
Journal of cancer research and clinical oncology 2008;134(2):211-7.
2008: Naoki Katase; Mehmet Gunduz; Levent Beder; Esra Gunduz; Mathieu Lefeuvre; Omer Faruk Hatipoglu; Silvia Susana Borkosky; Ryo Tamamura; Susumu Tominaga; Noboru Yamanaka; Kenji Shimizu; Noriyuki Nagai; Hitoshi Nagatsuka
Deletion at Dickkopf (dkk)-3 locus (11p15.2) is related with lower lymph node metastasis and better prognosis in head and neck squamous cell carcinomas.
Oncology research 2008;17(6):273-82.
2008: M Al Sheikh Ali; Mehmet Gunduz; Esra Gunduz; Ryo Tamamura; Levent Beder; S Tominaga; T Onoda; N Yamanaka; R Grenman; Kenji Shimizu; Noriyuki Nagai; Hitoshi Nagatsuka
Lack of B-RAF mutations in head and neck squamous cell carcinoma.
Folia biologica 2008;54(5):157-61.
2008: Hiromitsu Suzuki; Mamoru Ouchida; Hiromasa Yamamoto; Masaaki Yano; Shinichi Toyooka; Motoi Aoe; Nobuyoshi Shimizu; Hiroshi Date; Kenji Shimizu
Decreased expression of the SIN3A gene, a candidate tumor suppressor located at the prevalent allelic loss region 15q23 in non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2008;59(1):24-31.
2007: Hirotaka Kanzaki; Mamoru Ouchida; Hiroko Hanafusa; Akiko Sakai; Hiromasa Yamamoto; Hiromitsu Suzuki; Masaaki Yano; Motoi Aoe; Kazue Imai; Hiroshi Date; Kei Nakachi; Kenji Shimizu
Single nucleotide polymorphism in the RAD18 gene and risk of colorectal cancer in the Japanese population.
Oncology reports 2007;18(5):1171-5.
2007: Yusuke Matsumoto; Takeshi Nagasaka; Takeshi Kambara; Naoko Hoshizima; Jun Murakami; Hiromi Sasamoto; Masao Hosokawa; Yoshio Naomoto; Hiroshi Isozaki; Kenji Shimizu; Noriaki Tanaka; Nagahide Matsubara
Microsatellite instability and clinicopathological features in esophageal squamous cell cancer.
Oncology reports 2007;18(5):1123-7.
2007: Noriyasu Honjo; Mehmet Gunduz; Kunihiro Fukushima; Beyhan Cengiz; Levent Beder; Esra Gunduz; Hitoshi Nagatsuka; Jing Xiao; Kenji Shimizu; Kazunori Nishizaki
Comprehensive loss of heterozygosity analysis and identification of a novel hotspot at 3p21 in salivary gland neoplasms.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2007;137(1):119-25.
2007: Shuji Ichihara; Shinichi Toyooka; Yoshiro Fujiwara; Katsuyuki Hotta; Hisayuki Shigematsu; Masaki Tokumo; Junichi Soh; Hiroaki Asano; Kouichi Ichimura; Keisuke Aoe; Motoi Aoe; Katsuyuki Kiura; Kenji Shimizu; Hiroshi Date; Nobuyoshi Shimizu
The impact of epidermal growth factor receptor gene status on gefitinib-treated Japanese patients with non-small-cell lung cancer.
International journal of cancer. Journal international du cancer 2007;120(6):1239-47.
2007: Beyhan Cengiz; Mehmet Gunduz; Hitoshi Nagatsuka; Levent Beder; Esra Gunduz; Ryo Tamamura; Naila Mahmut; Kunihiro Fukushima; Mahmoud Al Sheikh Ali; Yoshio Naomoto; Kenji Shimizu; Noriyuki Nagai
Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer.
Oral oncology 2007;43(3):241-7.
2007: Kozo Masuda; Akio Hiraki; Nobuharu Fujii; Toshiyuki Watanabe; Motoyuki Tanaka; Kosei Matsue; Yoichiro Ogama; Mamoru Ouchida; Kenji Shimizu; Kazuma Ikeda; Mitsune Tanimoto
Loss or down-regulation of HLA class I expression at the allelic level in freshly isolated leukemic blasts.
Cancer science 2007;98(1):102-8.
2007: T Ishii; Jun Murakami; Kenji Notohara; Harry M Cullings; Hiromi Sasamoto; Takeshi Kambara; Y Shirakawa; Yoshio Naomoto; M Ouchida; Kenji Shimizu; Noriaki Tanaka; Jeremy R Jass; Nagahide Matsubara
Oesophageal squamous cell carcinoma may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa.
Gut 2007;56(1):13-9.
2006: Norihide Ohata; Sachio Ito; Aki Yoshida; Toshiyuki Kunisada; Kunihiko Numoto; Yoshimi Jitsumori; Hirotaka Kanzaki; Toshifumi Ozaki; Kenji Shimizu; Mamoru Ouchida
Highly frequent allelic loss of chromosome 6q16-23 in osteosarcoma: involvement of cyclin C in osteosarcoma.
International journal of molecular medicine 2006;18(6):1153-8.
2006: Yasuhiro Shiote; Mamoru Ouchida; Yoshimi Jitsumori; Yoichiro Ogama; Yoshinobu Matsuo; Fumihiko Ishimaru; Mitsune Tanimoto; Kenji Shimizu
Multiple splicing variants of Naf1/ABIN-1 transcripts and their alterations in hematopoietic tumors.
International journal of molecular medicine 2006;18(5):917-23.
2006: Hirotaka Kanzaki; Mamoru Ouchida; Hiroko Hanafusa; Masaaki Yano; Hiromitsu Suzuki; Motoi Aoe; Kazue Imai; Nobuyoshi Shimizu; Kei Nakachi; Kenji Shimizu
Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population.
International journal of molecular medicine 2006;18(2):279-84.
2006: Hirotaka Kanzaki; Hiroko Hanafusa; Hiromasa Yamamoto; Yukiko Yasuda; Kazue Imai; Masaaki Yano; Motoi Aoe; Nobuyoshi Shimizu; Kei Nakachi; Mamoru Ouchida; Kenji Shimizu
Single nucleotide polymorphism at codon 133 of the RASSF1 gene is preferentially associated with human lung adenocarcinoma risk.
Cancer letters 2006;238(1):128-34.
2006: Levent Beder; Mehmet Gunduz; Mamoru Ouchida; Esra Gunduz; Akiko Sakai; Kunihiro Fukushima; Hitoshi Nagatsuka; Sachio Ito; Noriyasu Honjo; Kazunori Nishizaki; Kenji Shimizu
Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer.
Journal of cancer research and clinical oncology 2006;132(1):19-27.
2005: Mehmet Gunduz; Hitoshi Nagatsuka; Kadir Demircan; Esra Gunduz; Beyhan Cengiz; Mamoru Ouchida; Hidetsugu Tsujigiwa; Eiki Yamachika; Kunihiro Fukushima; Levent Beder; Satoshi Hirohata; Yoshifumi Ninomiya; Kazunori Nishizaki; Kenji Shimizu; Noriyuki Nagai
Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas.
Gene 2005;356():109-17.
2005: Yasuo Shinno; Esra Gunduz; Mehmet Gunduz; Hitoshi Nagatsuka; Hidetsugu Tsujigiwa; Beyhan Cengiz; You-Jin Lee; Ryo Tamamura; Mamoru Ouchida; Kunihiro Fukushima; Kenji Shimizu; Noriyuki Nagai
Fine deletional mapping of chromosome 4q22-35 region in oral cancer.
International journal of molecular medicine 2005;16(1):93-8.
2005: Tatsuo Ito; Mamoru Ouchida; Yuki Morimoto; Aki Yoshida; Yoshimi Jitsumori; Toshifumi Ozaki; Hiroshi Sonobe; Hajime Inoue; Kenji Shimizu
Significant growth suppression of synovial sarcomas by the histone deacetylase inhibitor FK228 in vitro and in vivo.
Cancer letters 2005;224(2):311-9.
2005: Hiromasa Yamamoto; Hiroko Hanafusa; Mamoru Ouchida; Masaaki Yano; Hiromitsu Suzuki; Masakazu Murakami; Motoi Aoe; Nobuyoshi Shimizu; Kei Nakachi; Kenji Shimizu
Single nucleotide polymorphisms in the EXO1 gene and risk of colorectal cancer in a Japanese population.
Carcinogenesis 2005;26(2):411-6.
2005: Esra Gunduz; Mehmet Gunduz; Mamoru Ouchida; Hitoshi Nagatsuka; Levent Beder; Hidetsugu Tsujigiwa; Kunihiro Fukushima; Kazunori Nishizaki; Kenji Shimizu; Noriyuki Nagai
Genetic and epigenetic alterations of BRG1 promote oral cancer development.
International journal of oncology 2005;26(1):201-10.
2004: Tatsuo Ito; Mamoru Ouchida; Sachio Ito; Yoshimi Jitsumori; Yuki Morimoto; Toshifumi Ozaki; Akira Kawai; Hajime Inoue; Kenji Shimizu
SYT, a partner of SYT-SSX oncoprotein in synovial sarcomas, interacts with mSin3A, a component of histone deacetylase complex.
Laboratory investigation; a journal of technical methods and pathology 2004;84(11):1484-90.
2004: Masaaki Yano; Mamoru Ouchida; Hisayuki Shigematsu; Noriyoshi Tanaka; Koichi Ichimura; Kazuyasu Kobayashi; Yasuhiko Inaki; Shinichi Toyooka; Kazunori Tsukuda; Nobuyoshi Shimizu; Kenji Shimizu
Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer.
International journal of cancer. Journal international du cancer 2004;112(1):8-13.
2004: Yoichiro Ogama; Mamoru Ouchida; Tadashi Yoshino; Sachio Ito; Hidetaka Takimoto; Yasuhiro Shiote; Fumihiko Ishimaru; Mine Harada; Mitsune Tanimoto; Kenji Shimizu
Prevalent hyper-methylation of the CDH13 gene promoter in malignant B cell lymphomas.
International journal of oncology 2004;25(3):685-91.
2004: Haruki Kaku; Sachio Ito; Shin Ebara; Mamoru Ouchida; Yasutomo Nasu; Tomoyasu Tsushima; Hiromi Kumon; Kenji Shimizu
Positive correlation between allelic loss at chromosome 14q24-31 and poor prognosis of patients with renal cell carcinoma.
Urology 2004;64(1):176-81.
2003: Yuki Morimoto; Toshifumi Ozaki; Mamoru Ouchida; Norifumi Umehara; Norihide Ohata; Aki Yoshida; Kenji Shimizu; Hajime Inoue
Single nucleotide polymorphism in fibroblast growth factor receptor 4 at codon 388 is associated with prognosis in high-grade soft tissue sarcoma.
Cancer 2003;98(10):2245-50.
2003: Yuki Morimoto; Mamoru Ouchida; Toshifumi Ozaki; Akira Kawai; Tatsuo Ito; Aki Yoshida; Hajime Inoue; Kenji Shimizu
Splicing isoform of SYT-SSX fusion protein accelerates transcriptional activity and cell proliferation.
Cancer letters 2003;199(1):35-43.
2003: Shinichi Toyooka; Kazunori Tsukuda; Mamoru Ouchida; Motohiko Tanino; Yasuhiko Inaki; Kazuyasu Kobayashi; Masaaki Yano; Junichi Soh; Takuya Kobatake; Nobuyoshi Shimizu; Kenji Shimizu
Detection of codon 61 point mutations of the K-ras gene in lung and colorectal cancers by enriched PCR.
Oncology reports 2003;10(5):1455-9.
2003: Levent Beder; Mehmet Gunduz; Mamoru Ouchida; Kunihiro Fukushima; Esra Gunduz; Sachio Ito; Akiko Sakai; Noriyuki Nagai; Kazunori Nishizaki; Kenji Shimizu
Genome-wide analyses on loss of heterozygosity in head and neck squamous cell carcinomas.
Laboratory investigation; a journal of technical methods and pathology 2003;83(1):99-105.
2002: Takashi Oka; Mamoru Ouchida; Maho Koyama; Yoichiro Ogama; Shinichi Takada; Yoko Nakatani; Takehiro Tanaka; Tadashi Yoshino; Kazuhiko Hayashi; Nobuya Ohara; Eisaku Kondo; Kiyoshi Takahashi; Junjiro Tsuchiyama; Mitsune Tanimoto; Kenji Shimizu; Tadaatsu Akagi
Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas.
Cancer research 2002;62(22):6390-4.
2002: H Moriyama; Nagahide Matsubara; T Kanbara; M Mori; J Matsuoka; T Yoshino; N Takakura; Kenji Shimizu; N Takaka
Allelic imbalance and microsatellite instability in plasma DNA released from polyclonal pancreatic adenocarcinoma.
International journal of oncology 2002;21(5):949-56.
2002: Mehmet Gunduz; Mamoru Ouchida; Kunihiro Fukushima; Sachio Ito; Yoshimi Jitsumori; Tomoko Nakashima; Noriyuki Nagai; Kazunori Nishizaki; Kenji Shimizu
Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers.
Oncogene 2002;21(28):4462-70.
2002: Nagahide Matsubara; T Yoshitaka; H Hanafusa; Noriaki Tanaka; Kenji Shimizu
Genetic alterations of the ornithine decarboxylase gene in human colorectal cancers.
Journal of experimental & clinical cancer research : CR 2002;21(2):191-5.
2002: H Moriyama; Hiromi Sasamoto; Takeshi Kambara; Nagahide Matsubara; M Ikeda; S Baba; Meltzer Stephen J.; H T Lynch; Kenji Shimizu; Noriaki Tanaka
E2F-4 mutation in hereditary non-polyposis colorectal cancer.
Journal of experimental & clinical cancer research : CR 2002;21(2):185-9.
2002: Kazuyasu Kobayashi; Mamoru Ouchida; Toshiya Tsuji; Hiroko Hanafusa; Masahiro Miyazaki; Masayoshi Namba; Nobuyoshi Shimizu; Kenji Shimizu
Reduced expression of the REIC/Dkk-3 gene by promoter-hypermethylation in human tumor cells.
Gene 2002;282(1-2):151-8.
2001: H Takashima; Y Matsumoto; Nagahide Matsubara; Y Shirakawa; R Kawashima; Motohiko Tanino; S Ito; H Isozaki; Mamoru Ouchida; Meltzer Stephen J.; Kenji Shimizu; Noriaki Tanaka
Effect of naturally occurring E2F-4 alterations on transcriptional activation and proliferation in transfected cells.
Laboratory investigation; a journal of technical methods and pathology 2001;81(11):1565-73.
2001: Takeshi Kambara; Nagahide Matsubara; H Nakagawa; Kenji Notohara; Takeshi Nagasaka; T Yoshino; Hiroshi Isozaki; Gerald B Sharp; Kenji Shimizu; J Jass; Noriaki Tanaka
High frequency of low-level microsatellite instability in early colorectal cancer.
Cancer research 2001;61(21):7743-6.
2000: S Toyooka; Mamoru Ouchida; Yoshimi Jitsumori; K Tsukuda; A Sakai; A Nakamura; N Shimizu; Kenji Shimizu
HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3.
Biochemical and biophysical research communications 2000;278(3):671-8.
2000: Kazunori Tsukuda; Motohiko Tanino; H Soga; Nobuyoshi Shimizu; Kenji Shimizu
A novel activating mutation of the K-ras gene in human primary colon adenocarcinoma.
Biochemical and biophysical research communications 2000;278(3):653-8.
2000: M Gunduz; Mamoru Ouchida; K Fukushima; Hiroko Hanafusa; T Etani; S Nishioka; K Nishizaki; Kenji Shimizu
Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.
Cancer research 2000;60(12):3143-6.
1999: Motohiko Tanino; M Matsuo; A Uenaka; Kazunori Tsukuda; Mamoru Ouchida; E Nakayama; Kenji Shimizu
Transforming activity of the RL-akt gene, a c-akt gene activated by long terminal repeat insertion in murine leukemia RL(male symbol)1 cells.
Molecular carcinogenesis 1999;26(4):286-97.