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Kazuya Shimizu

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Yoshikazu Tsukasaki; Kazuo Kitamura; Kazuya Shimizu; Atsuko Hikikoshi Iwane; Yoshimi Takai; Toshio Yanagida
Role of multiple bonds between the single cell adhesion molecules, nectin and cadherin, revealed by high sensitive force measurements.
Tomomi Kawakatsu; Hisakazu Ogita; Tatsuro Fukuhara; Taihei Fukuyama; Yukiko Minami; Kazuya Shimizu; Yoshimi Takai
Vav2 as a Rac-GDP/GTP exchange factor responsible for the nectin-induced, c-Src- and Cdc42-mediated activation of Rac.
Taihei Fukuyama; Hisakazu Ogita; Tomomi Kawakatsu; Tatsuro Fukuhara; Tomohiro Yamada; Tatsuhiro Sato; Kazuya Shimizu; Takeshi Nakamura; Michiyuki Matsuda; Yoshimi Takai
Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions.

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All Publications

2007: Yoshikazu Tsukasaki; Kazuo Kitamura; Kazuya Shimizu; Atsuko Hikikoshi Iwane; Yoshimi Takai; Toshio Yanagida
Role of multiple bonds between the single cell adhesion molecules, nectin and cadherin, revealed by high sensitive force measurements.
Journal of molecular biology 2007;367(4):996-1006.
2005: Tomomi Kawakatsu; Hisakazu Ogita; Tatsuro Fukuhara; Taihei Fukuyama; Yukiko Minami; Kazuya Shimizu; Yoshimi Takai
Vav2 as a Rac-GDP/GTP exchange factor responsible for the nectin-induced, c-Src- and Cdc42-mediated activation of Rac.
The Journal of biological chemistry 2005;280(6):4940-7.
2005: Taihei Fukuyama; Hisakazu Ogita; Tomomi Kawakatsu; Tatsuro Fukuhara; Tomohiro Yamada; Tatsuhiro Sato; Kazuya Shimizu; Takeshi Nakamura; Michiyuki Matsuda; Yoshimi Takai
Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions.
The Journal of biological chemistry 2005;280(1):815-25.
2004: Kenji Irie; Kazuya Shimizu; Toshiaki Sakisaka; Wataru Ikeda; Yoshimi Takai
Roles and modes of action of nectins in cell-cell adhesion.
Seminars in cell & developmental biology 2004;15(6):643-56.
2004: Noriko Okabe; Kazuya Shimizu; Kumi Ozaki-Kuroda; Hiroyuki Nakanishi; Koji Morimoto; Masakazu Takeuchi; Hironobu Katsumaru; Fujio Murakami; Yoshimi Takai
Contacts between the commissural axons and the floor plate cells are mediated by nectins.
Developmental biology 2004;273(2):244-56.
2004: Tatsuro Fukuhara; Kazuya Shimizu; Tomomi Kawakatsu; Taihei Fukuyama; Yukiko Minami; Tomoyuki Honda; Takashi Hoshino; Tomohiro Yamada; Hisakazu Ogita; Masato Okada; Yoshimi Takai
Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG.
The Journal of cell biology 2004;166(3):393-405.
2004: Noriko Okabe; Kumi Ozaki-Kuroda; Hiroyuki Nakanishi; Kazuya Shimizu; Yoshimi Takai
Expression patterns of nectins and afadin during epithelial remodeling in the mouse embryo.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;230(1):174-86.
2004: Takashi Hoshino; Kazuya Shimizu; Tomoyuki Honda; Tomomi Kawakatsu; Taihei Fukuyama; Takeshi Nakamura; Michiyuki Matsuda; Yoshimi Takai
A novel role of nectins in inhibition of the E-cadherin-induced activation of Rac and formation of cell-cell adherens junctions.
Molecular biology of the cell 2004;15(3):1077-88.
2004: Kenji Irie; Kazuya Shimizu; Toshiaki Sakisaka; Wataru Ikeda; Yoshimi Takai
Roles of nectins in cell adhesion, signaling and polarization.
Handbook of experimental pharmacology 2004;(165):343-72.
2003: Atsunori Fukuhara; Kazuya Shimizu; Tomomi Kawakatsu; Tatsuro Fukuhara; Yoshimi Takai
Involvement of nectin-activated Cdc42 small G protein in organization of adherens and tight junctions in Madin-Darby canine kidney cells.
The Journal of biological chemistry 2003;278(51):51885-93.
2003: Kazuya Shimizu; Yoshimi Takai
Roles of the intercellular adhesion molecule nectin in intracellular signaling.
Journal of biochemistry 2003;134(5):631-6.
2003: Yoshimi Takai; Kazuya Shimizu; Toshihisa Ohtsuka
The roles of cadherins and nectins in interneuronal synapse formation.
Current opinion in neurobiology 2003;13(5):520-6.
2003: Yoshimi Takai; Kenji Irie; Kazuya Shimizu; Toshiaki Sakisaka; Wataru Ikeda
Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization.
Cancer science 2003;94(8):655-67.
2003: Tomoyuki Honda; Kazuya Shimizu; Atsunori Fukuhara; Kenji Irie; Yoshimi Takai
Regulation by nectin of the velocity of the formation of adherens junctions and tight junctions.
Biochemical and biophysical research communications 2003;306(1):104-9.
2003: Tomoyuki Honda; Kazuya Shimizu; Tomomi Kawakatsu; Atsunori Fukuhara; Kenji Irie; Takeshi Nakamura; Michiyuki Matsuda; Yoshimi Takai
Cdc42 and Rac small G proteins activated by trans-interactions of nectins are involved in activation of c-Jun N-terminal kinase, but not in association of nectins and cadherin to form adherens junctions, in fibroblasts.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(5):481-91.
2003: Tatsuo Katata; Kenji Irie; Atsunori Fukuhara; Tomomi Kawakatsu; Akio Yamada; Kazuya Shimizu; Yoshimi Takai
Involvement of nectin in the localization of IQGAP1 at the cell-cell adhesion sites through the actin cytoskeleton in Madin-Darby canine kidney cells.
Oncogene 2003;22(14):2097-109.
2003: Yoshinari Tanaka; Hiroyuki Nakanishi; Shigeki Kakunaga; Noriko Okabe; Tomomi Kawakatsu; Kazuya Shimizu; Yoshimi Takai
Role of nectin in formation of E-cadherin-based adherens junctions in keratinocytes: analysis with the N-cadherin dominant negative mutant.
Molecular biology of the cell 2003;14(4):1597-609.
2003: Masato Yasumi; Kazuya Shimizu; Tomoyuki Honda; Masakazu Takeuchi; Yoshimi Takai
Role of each immunoglobulin-like loop of nectin for its cell-cell adhesion activity.
Biochemical and biophysical research communications 2003;302(1):61-6.
2003: Tomoyuki Honda; Kazuya Shimizu; Tomomi Kawakatsu; Masato Yasumi; Tatsushi Shingai; Atsunori Fukuhara; Kumi Ozaki-Kuroda; Kenji Irie; Hiroyuki Nakanishi; Yoshimi Takai
Antagonistic and agonistic effects of an extracellular fragment of nectin on formation of E-cadherin-based cell-cell adhesion.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(1):51-63.
2002: Tomomi Kawakatsu; Kazuya Shimizu; Tomoyuki Honda; Tatsuro Fukuhara; Takashi Hoshino; Yoshimi Takai
Trans-interactions of nectins induce formation of filopodia and Lamellipodia through the respective activation of Cdc42 and Rac small G proteins.
The Journal of biological chemistry 2002;277(52):50749-55.
2002: Atsunori Fukuhara; Kenji Irie; Hiroyuki Nakanishi; Kyoji Takekuni; Tomomi Kawakatsu; Wataru Ikeda; Akio Yamada; Tatsuo Katata; Tomoyuki Honda; Tatsuhiro Sato; Kazuya Shimizu; Harunobu Ozaki; Hisanori Horiuchi; Toru Kita; Yoshimi Takai
Involvement of nectin in the localization of junctional adhesion molecule at tight junctions.
Oncogene 2002;21(50):7642-55.
2002: Atsunori Fukuhara; Kenji Irie; Akio Yamada; Tatsuo Katata; Tomoyuki Honda; Kazuya Shimizu; Hiroyuki Nakanishi; Yoshimi Takai
Role of nectin in organization of tight junctions in epithelial cells.
Genes to cells : devoted to molecular & cellular mechanisms 2002;7(10):1059-72.
2002: Yumiko Momose; Tomoyuki Honda; Maiko Inagaki; Kazuya Shimizu; Kenji Irie; Hiroyuki Nakanishi; Yoshimi Takai
Role of the second immunoglobulin-like loop of nectin in cell-cell adhesion.
Biochemical and biophysical research communications 2002;293(1):45-9.
1998: Tatsuji Fujiwara; Keiichi Tanaka; Akihisa Mino; M Kikyo; Kiyohisa Takahashi; Kazuya Shimizu; Yoshimi Takai
Rho1p-Bni1p-Spa2p interactions: implication in localization of Bni1p at the bud site and regulation of the actin cytoskeleton in Saccharomyces cerevisiae.
Molecular biology of the cell 1998;9(5):1221-33.
1998: M Umikawa; Keiichi Tanaka; T Kamei; Kazuya Shimizu; H Imamura; Takuya Sasaki; Yoshimi Takai
Interaction of Rho1p target Bni1p with F-actin-binding elongation factor 1alpha: implication in Rho1p-regulated reorganization of the actin cytoskeleton in Saccharomyces cerevisiae.
Oncogene 1998;16(15):2011-6.
1998: Kazuya Shimizu; H Shirataki; Takeshi Honda; S Minami; Yoshimi Takai
Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide.
The Journal of biological chemistry 1998;273(12):6591-4.
1997: Y Ihara; Yoshihiro Sakamoto; M Mihara; Kazuya Shimizu; Naoyuki Taniguchi
Overexpression of N-acetylglucosaminyltransferase III disrupts the tyrosine phosphorylation of Trk with resultant signaling dysfunction in PC12 cells treated with nerve growth factor.
The Journal of biological chemistry 1997;272(15):9629-34.
1996: Kazuya Shimizu; H Kawabe; S Minami; Takeshi Honda; K Takaishi; H Shirataki; Yoshimi Takai
SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase.
The Journal of biological chemistry 1996;271(43):27013-7.
1996: Shun'ichi Kuroda; T Ohtsuka; B Yamamori; Kenji Fukui; Kazuya Shimizu; Yoshimi Takai
Different effects of various phospholipids on Ki-Ras-, Ha-Ras-, and Rap1B-induced B-Raf activation.
The Journal of biological chemistry 1996;271(25):14680-3.
1996: T Ohtsuka; Kazuya Shimizu; B Yamamori; Shun'ichi Kuroda; Yoshimi Takai
Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein.
The Journal of biological chemistry 1996;271(3):1258-61.
1995: B Yamamori; Shun'ichi Kuroda; Kazuya Shimizu; Kenji Fukui; T Ohtsuka; Yoshimi Takai
Purification of a Ras-dependent mitogen-activated protein kinase kinase kinase from bovine brain cytosol and its identification as a complex of B-Raf and 14-3-3 proteins.
The Journal of biological chemistry 1995;270(20):11723-6.
1995: Shun'ichi Kuroda; Kazuya Shimizu; B Yamamori; S Matsuda; K Imazumi; Kozo Kaibuchi; Yoshimi Takai
Purification and characterization of REKS from Xenopus eggs. Identification of REKS as a Ras-dependent mitogen-activated protein kinase kinase kinase.
The Journal of biological chemistry 1995;270(6):2460-5.
1995: Shun'ichi Kuroda; Kazuya Shimizu; B Yamamori; Yoshimi Takai
Cell-free assay system for Ras-dependent MEK activation.
Methods in enzymology 1995;255():257-65.
1994: Kazuya Shimizu; Shun'ichi Kuroda; B Yamamori; S Matsuda; Kozo Kaibuchi; T Yamauchi; T Isobe; K Irie; K Matsumoto; Yoshimi Takai
Synergistic activation by Ras and 14-3-3 protein of a mitogen-activated protein kinase kinase kinase named Ras-dependent extracellular signal-regulated kinase kinase stimulator.
The Journal of biological chemistry 1994;269(37):22917-20.