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Shigeomi Shimizu

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Ikuhiko Nakase; Shinya Okumura; Sílvia Pujals; Shigeomi Shimizu; Hirofumi Yamaguchi; Satoko Arakawa; Hisaaki Hirose; Sayaka Katayama; Shiroh Futaki
Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine.
Shigeomi Shimizu
[Drugs that activates apoptosis].
Yuichiro Miyaoka; Shigeomi Shimizu; Satoko Arakawa; Kazuki Ebato; Hidenori Kato; Atsushi Miyajima
Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration.

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2012: Ikuhiko Nakase; Shinya Okumura; Sílvia Pujals; Shigeomi Shimizu; Hirofumi Yamaguchi; Satoko Arakawa; Hisaaki Hirose; Sayaka Katayama; Shiroh Futaki
Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine.
Chemical communications (Cambridge, England) 2012;48(90):11097-9.
2012: Shigeomi Shimizu
[Drugs that activates apoptosis].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 8():125-9.
2012: Yuichiro Miyaoka; Shigeomi Shimizu; Satoko Arakawa; Kazuki Ebato; Hidenori Kato; Atsushi Miyajima
Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration.
Current biology : CB 2012;22(13):1166-75.
2012: Yasuhiko Yoshioka; Shigeomi Shimizu; Masahiko Taniguchi; Toshinori Ito; Toshirou Nishida; Masaya Nomura; Yoshiki Sawa
p53 inhibits vascular endothelial growth factor expression in solid tumor.
The Journal of surgical research 2012;174(2):291-7.
2012: Akimitsu Konishi; Satoko Arakawa; Zhenyu Yue; Shigeomi Shimizu
Involvement of Beclin 1 in engulfment of apoptotic cells.
The Journal of biological chemistry 2012;287(17):13919-29.
2012: Makoto Fukumatsu; Minsoo Kim; Hitomi Mimuro; Kazuhisa Nakayama; Michinaga Ogawa; Shigeomi Shimizu; Masato Suzuki; Satoko Arakawa; Chihiro Sasakawa
Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cells.
Cell host & microbe 2012;11(4):325-36.
2011: Shigeomi Shimizu
[Apoptosis and non-apoptotic cell death].
[Rinshō ketsueki] The Japanese journal of clinical hematology 2011;52(10):1669-76.
2011: Hayato Hikita; Naoki Hiramatsu; Atsushi Hosui; Hisashi Ishida; Tatsuya Kanto; Takahiro Kodama; Wei Li; Takuya Miyagi; Minoru Shigekawa; Shigeomi Shimizu; S Shimizu; Tetsuo Takehara; Tomohide Tatsumi; Yoshihide Tsujimoto; Norio Hayashi
Delayed-onset caspase-dependent massive hepatocyte apoptosis upon Fas activation in Bak/Bax-deficient mice.
Hepatology (Baltimore, Md.) 2011;54(1):240-51.
2011: Masako Narita; Andrew R J Young; Satoko Arakawa; shamith samarajiwa; Takayuki Nakashima; Sei Yoshida; Sungki Hong; Lorraine S Berry; Stefanie Reichelt; Manuela Ferreira; Simon Tavaré; Ken Inoki; Shigeomi Shimizu; Masashi Narita
Spatial coupling of mTOR and autophagy augments secretory phenotypes.
Science (New York, N.Y.) 2011;332(6032):966-70.
2010: Koki Kamiya; Kanta Tsumoto; Satoko Arakawa; Shigeomi Shimizu; Ikuo Morita; Tetsuro Yoshimura; Kazunari Akiyoshi
Preparation of connexin43-integrated giant Liposomes by a baculovirus expression-liposome fusion method.
Biotechnology and bioengineering 2010;107(5):836-43.
2010: Tatsushi Yoshida; Takeshi Mizuta; Shigeomi Shimizu
Neurodegeneration in mnd2 mutant mice is not prevented by parkin transgene.
Biochemical and biophysical research communications 2010;402(4):676-9.
2010: Shigeomi Shimizu; Akio Konishi; Y Nishida; T Mizuta; H Nishina; A Yamamoto; Yoshihide Tsujimoto
Involvement of JNK in the regulation of autophagic cell death.
Oncogene 2010;29(14):2070-82.
2010: Ami Nabeyama; Ai Kurita; Kenichi Asano; Yasunobu Miyake; Takuwa Yasuda; Ikuo Miura; Gen Nishitai; Satoko Arakawa; Shigeomi Shimizu; Shigeharu Wakana; Hisahiro Yoshida; Masato Tanaka
xCT deficiency accelerates chemically induced tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(14):6436-41.
2010: Kan Ideguchi; Shigeomi Shimizu; Meinoshin Okumura; Yoshihide Tsujimoto
Cyclophilin D-dependent mitochondrial permeability transition is not involved in neurodegeneration in mnd2 mutant mice.
Biochemical and biophysical research communications 2010;393(2):264-7.
2010: Shigeomi Shimizu; Satoko Arakawa; Yuya Nishida
Autophagy takes an alternative pathway.
Autophagy 2010;6(2):290-1.
2010: Akihiro Mouri; Yukihiro Noda; Shigeomi Shimizu; Yoshihide Tsujimoto; Toshitaka Nabeshima
The role of cyclophilin D in learning and memory.
Hippocampus 2010;20(2):293-304.
2009: Shin-ichiro Hayashi; Akitsugu Yamamoto; Fukka You; Kentaro Yamashita; Yuka Ikegame; Masahiro Tawada; Tamotsu Yoshimori; Shigeomi Shimizu; Shigeru Nakashima
The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy.
The American journal of pathology 2009;175(5):2226-34.
2009: Hiroki Shimada; Kei-Ichi Hirai; Eriko Simamura; Toshihisa Hatta; Hiroki Iwakiri; Keiji Mizuki; Taizo Hatta; Tatsuya Sawasaki; Satoko Matsunaga; Yaeta Endo; Shigeomi Shimizu
Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependent oxidoreductase.
The Journal of biological chemistry 2009;284(42):28642-9.
2009: Hidehisa Yamagata; Shigeomi Shimizu; Y Nishida; Y Watanabe; W J Craigen; Yoshihide Tsujimoto
Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax.
Oncogene 2009;28(40):3563-72.
2009: Yuya Nishida; Satoko Arakawa; Kenji Fujitani; Hirofumi Yamaguchi; Takeshi Mizuta; Toku Kanaseki; Masaaki Komatsu; Kinya Otsu; Yoshihide Tsujimoto; Shigeomi Shimizu
Discovery of Atg5/Atg7-independent alternative macroautophagy.
Nature 2009;461(7264):654-8.
2009: Masashi Kato; Masaharu Akao; Madoka Matsumoto-Ida; Takeru Makiyama; Moritake Iguchi; Toshihiro Takeda; Shigeomi Shimizu; Toru Kita
The targeting of cyclophilin D by RNAi as a novel cardioprotective therapy: evidence from two-photon imaging.
Cardiovascular research 2009;83(2):335-44.
2009: Andrew R J Young; Masako Narita; Manuela Ferreira; Kristina Kirschner; Mahito Sadaie; Jeremy F J Darot; Simon Tavaré; Satoko Arakawa; Shigeomi Shimizu; Fiona M Watt; Masashi Narita
Autophagy mediates the mitotic senescence transition.
Genes & development 2009;23(7):798-803.
2009: Yoshitaka Isaka; C Suzuki; T Abe; Masayoshi Okumi; Naotsugu Ichimaru; Ryoichi Imamura; Y Kakuta; I Matsui; Yoshitsugu Takabatake; H Rakugi; Shigeomi Shimizu; Shiro Takahara
Bcl-2 protects tubular epithelial cells from ischemia/reperfusion injury by dual mechanisms.
Transplantation proceedings 2009;41(1):52-4.
2008: Reina Inagaki; Kazuhiko Tagawa; Mei-Ling Qi; Yasushi Enokido; Hikaru Ito; Takuya Tamura; Shigeomi Shimizu; Kiyomitsu Oyanagi; Nobutaka Arai; Ichiro Kanazawa; Erich E Wanker; hitoshi okazawa
Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease.
The European journal of neuroscience 2008;28(1):30-40.
2008: Kenji Kajitani; Masahiro Fujihashi; Yukiko Kobayashi; Shigeomi Shimizu; Yoshihide Tsujimoto; Kunio Miki
Crystal structure of human cyclophilin D in complex with its inhibitor, cyclosporin A at 0.96-A resolution.
Proteins 2008;70(4):1635-9.
2008: Chigure Suzuki; Yoshitaka Isaka; Shigeomi Shimizu; Yoshihide Tsujimoto; Yoshitsugu Takabatake; Takahito Ito; Shiro Takahara; Enyu Imai
Bcl-2 protects tubular epithelial cells from ischemia reperfusion injury by inhibiting apoptosis.
Cell transplantation 2008;17(1-2):223-9.
2007: Takeshi Mizuta; Shigeomi Shimizu; Yousuke Matsuoka; Takashi Nakagawa; Yoshihide Tsujimoto
A Bax/Bak-independent mechanism of cytochrome c release.
The Journal of biological chemistry 2007;282(22):16623-30.
2007: Yoshihide Tsujimoto; Shigeomi Shimizu
Role of the mitochondrial membrane permeability transition in cell death.
Apoptosis : an international journal on programmed cell death 2007;12(5):835-40.
2006: Eriko Simamura; Kei-Ichi Hirai; Hiroki Shimada; Junko Koyama; Yukie Niwa; Shigeomi Shimizu
Furanonaphthoquinones cause apoptosis of cancer cells by inducing the production of reactive oxygen species by the mitochondrial voltage-dependent anion channel.
Cancer biology & therapy 2006;5(11):1523-9.
2006: Shigeomi Shimizu
[Molecular mechanisms of DNA damage-induced apoptosis].
Seikagaku. The Journal of Japanese Biochemical Society 2006;78(9):891-4.
2006: Yoshihide Tsujimoto; Takashi Nakagawa; Shigeomi Shimizu
Mitochondrial membrane permeability transition and cell death.
Biochimica et biophysica acta 2006;1757(9-10):1297-300.
2006: Ken Ito; Yusuke Oji; Naoya Tatsumi; Shigeomi Shimizu; Y Kanai; Tsutomu Nakazawa; Momotaro Asada; Tanyarat Jomgeow; S Aoyagi; Yoko Nakano; Hiroya Tamaki; Nao Sakaguchi; Toshiaki Shirakata; Sumiyuki Nishida; Manabu Kawakami; Akihiro Tsuboi; Yoshihiro Oka; Yoshihide Tsujimoto; Haruo Sugiyama
Antiapoptotic function of 17AA(+)WT1 (Wilms' tumor gene) isoforms on the intrinsic apoptosis pathway.
Oncogene 2006;25(30):4217-29.
2005: Yoshihide Tsujimoto; Shigeomi Shimizu
Another way to die: autophagic programmed cell death.
Cell death and differentiation 2005;12 Suppl 2():1528-34.
2005: Naoko Takahashi; Shinya Kobayashi; Shinichi Kajino; Kenichi Imai; Keisuke Tomoda; Shigeomi Shimizu; Takashi Okamoto
Inhibition of the 53BP2S-mediated apoptosis by nuclear factor kappaB and Bcl-2 family proteins.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(8):803-11.
2005: Chen Chen; Shigeomi Shimizu; Yoshihide Tsujimoto; Noboru Motoyama
Chk2 regulates transcription-independent p53-mediated apoptosis in response to DNA damage.
Biochemical and biophysical research communications 2005;333(2):427-31.
2005: Lilin Zhang; Shigeomi Shimizu; Yoshihide Tsujimoto
Two distinct Fas-activated signaling pathways revealed by an antitumor drug D609.
Oncogene 2005;24(18):2954-62.
2005: Takashi Nakagawa; Shigeomi Shimizu; Tetsuya Watanabe; Osamu Yamaguchi; Kinya Otsu; Hirotaka Yamagata; Hidenori Inohara; Takeshi Kubo; Yoshihide Tsujimoto
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death.
Nature 2005;434(7033):652-8.
2005: Masamichi Ono; Yoshiki Sawa; Masahiro Ryugo; Alexey N. Aleshin; Shigeomi Shimizu; Rie Sugioka; Yoshihide Tsujimoto; Hikaru Matsuda
BH4 peptide derivative from Bcl-xL attenuates ischemia/reperfusion injury thorough anti-apoptotic mechanism in rat hearts.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2005;27(1):117-21.
2004: Rie Sugioka; Shigeomi Shimizu; Yoshihide Tsujimoto
Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis.
The Journal of biological chemistry 2004;279(50):52726-34.
2004: Shigeomi Shimizu; Toku Kanaseki; Noboru Mizushima; Takeshi Mizuta; Satoko Arakawa-Kobayashi; Craig Thompson; Yoshihide Tsujimoto
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes.
Nature cell biology 2004;6(12):1221-8.
2004: Lilin Zhang; Shigeomi Shimizu; Kazuhiro Sakamaki; Shin Yonehara; Yoshihide Tsujimoto
A caspase-8-independent signaling pathway activated by Fas ligation leads to exposure of the Bak N terminus.
The Journal of biological chemistry 2004;279(32):33865-74.
2004: Fuminori Tsuruta; Jun Sunayama; Yasunori Mori; Seisuke Hattori; Shigeomi Shimizu; Yoshihide Tsujimoto; Katsuji Yoshioka; Norihisa Masuyama; Yukiko Gotoh
JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins.
The EMBO journal 2004;23(8):1889-99.
2004: Shigeomi Shimizu; Akimitsu Konishi; Yoshihide Tujimoto
[X-ray-induced DNA damage and apoptosis].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2004;49(5):601-7.
2003: Rie Sugioka; Shigeomi Shimizu; Toshihiro Funatsu; Hiroshi Tamagawa; Yoshiki Sawa; Toru Kawakami; Yoshihide Tsujimoto
BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo.
Oncogene 2003;22(52):8432-40.
2003: Akio Konishi; Shigeomi Shimizu; Junko Hirota; Toshifumi Takao; Yuhong Fan; Yosuke Matsuoka; Lilin Zhang; Yoshihiro Yoneda; Yoshitaka Fujii; Arthur I Skoultchi; Yoshihide Tsujimoto
Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks.
Cell 2003;114(6):673-88.
2003: Masaya Nomura; Shigeomi Shimizu; Tomoyasu Sugiyama; Masashi Narita; Toshinori Ito; Hikaru Matsuda; Yoshihide Tsujimoto
14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax.
The Journal of biological chemistry 2003;278(3):2058-65.
2003: Hiroshi Hosoda; Masayasu Kojima; Tsunekazu Mizushima; Shigeomi Shimizu; Kenji Kangawa
Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing.
The Journal of biological chemistry 2003;278(1):64-70.
2002: Yasuo Shinohara; Mohamad Radwan Almofti; Takenori Yamamoto; Taro Ishida; Fumiyo Kita; Hideki Kanzaki; Masakatsu Ohnishi; Kikuji Yamashita; Shigeomi Shimizu; Hiroshi Terada
Permeability transition-independent release of mitochondrial cytochrome c induced by valinomycin.
European journal of biochemistry / FEBS 2002;269(21):5224-30.
2002: Yukihiro Akao; Wakako Maruyama; Shigeomi Shimizu; Hong Yi; Yoshihito Nakagawa; Masayo Shamoto-Nagai; Moussa B H Youdim; Yoshihide Tsujimoto; Makoto Naoi
Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan.
Journal of neurochemistry 2002;82(4):913-23.
2002: Tomoyasu Sugiyama; Shigeomi Shimizu; Yosuke Matsuoka; Yoshihiro Yoneda; Yoshihide Tsujimoto
Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim.
Oncogene 2002;21(32):4944-56.
2002: Yoshihide Tsujimoto; Shigeomi Shimizu
The voltage-dependent anion channel: an essential player in apoptosis.
Biochimie 2002;84(2-3):187-93.
2001: Ichiro Hanamura; Shinsuke Iida; Y Akano; Yoshihito Hayami; Miyuki Kato; Kazuhisa Miura; Shinsuke Harada; Shogo Banno; Atsushi Wakita; H Kiyoi; T Naoe; Shigeomi Shimizu; Shin-ichi Sonta; Masakazu Nitta; Masafumi Taniwaki; Ryuzo Ueda
Ectopic expression of MAFB gene in human myeloma cells carrying (14;20)(q32;q11) chromosomal translocations.
Japanese journal of cancer research : Gann 2001;92(6):638-44.
2001: Shigeomi Shimizu; Yosuke Matsuoka; Y Shinohara; Yoshihiro Yoneda; Yoshihide Tsujimoto
Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells.
The Journal of cell biology 2001;152(2):237-50.
2000: Yoshihide Tsujimoto; Shigeomi Shimizu
VDAC regulation by the Bcl-2 family of proteins.
Cell death and differentiation 2000;7(12):1174-81.
2000: H Kusano; Shigeomi Shimizu; Richard C Koya; Hisakazu Fujita; Sayo Kamada; Noboru Kuzumaki; Yoshihide Tsujimoto
Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC.
Oncogene 2000;19(42):4807-14.
2000: Shigeomi Shimizu; Y Shinohara; Yoshihide Tsujimoto
Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator.
Oncogene 2000;19(38):4309-18.
2000: Richard C Koya; Hisakazu Fujita; Shigeomi Shimizu; Makoto Ohtsu; Masato Takimoto; Yoshihide Tsujimoto; Noboru Kuzumaki
Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release.
The Journal of biological chemistry 2000;275(20):15343-9.
2000: Shigeomi Shimizu; T Ide; T Yanagida; Yoshihide Tsujimoto
Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c.
The Journal of biological chemistry 2000;275(16):12321-5.
2000: Shigeomi Shimizu; Akio Konishi; T Kodama; Yoshihide Tsujimoto
BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3100-5.
2000: Yoshihide Tsujimoto; Shigeomi Shimizu
Bcl-2 family: life-or-death switch.
FEBS letters 2000;466(1):6-10.
2000: Shigeomi Shimizu; Yoshihide Tsujimoto
Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):577-82.
1999: K Yamabe; Shigeomi Shimizu; Takashi Ito; Yasuo Yoshioka; M Nomura; M Narita; I Saito; Y Kanegae; Hikaru Matsuda
Cancer gene therapy using a pro-apoptotic gene, caspase-3.
Gene therapy 1999;6(12):1952-9.
1999: Shonen Yoshida; N Nakazawa; Shinsuke Iida; Yoshihito Hayami; S Sato; Atsushi Wakita; Shigeomi Shimizu; Masafumi Taniwaki; Ryuzo Ueda
Detection of MUM1/IRF4-IgH fusion in multiple myeloma.
Leukemia 1999;13(11):1812-6.
1999: Tomonari Imazu; Shigeomi Shimizu; Shinji Tagami; M Matsushima; Yusuke Nakamura; Tsuneharu Miki; Akihiko Okuyama; Yoshihide Tsujimoto
Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability.
Oncogene 1999;18(32):4523-9.
1999: Shigeomi Shimizu; M Narita; Yoshihide Tsujimoto
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC.
Nature 1999;399(6735):483-7.
1998: S Okuno; Shigeomi Shimizu; Takashi Ito; Masaya Nomura; E Hamada; Yoshihide Tsujimoto; Hikaru Matsuda
Bcl-2 prevents caspase-independent cell death.
The Journal of biological chemistry 1998;273(51):34272-7.
1998: M Narita; Shigeomi Shimizu; Takashi Ito; Thomas Chittenden; Robert J Lutz; H Matsuda; Yoshihide Tsujimoto
Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14681-6.
1998: H Tanabe; Y Eguchi; Shigeomi Shimizu; J C Martinou; Yoshihide Tsujimoto
Death-signalling cascade in mouse cerebellar granule neurons.
The European journal of neuroscience 1998;10(4):1403-11.
1998: Shigeomi Shimizu; Y Eguchi; Wataru Kamiike; Y Funahashi; A Mignon; V Lacronique; H Matsuda; Yoshihide Tsujimoto
Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1455-9.
1998: K Yamabe; Shigeomi Shimizu; Wataru Kamiike; Satoshi Waguri; Y Eguchi; J Hasegawa; S Okuno; Yasuo Yoshioka; Takashi Ito; Yoshiki Sawa; Yasuo Uchiyama; Yoshihide Tsujimoto; Hikaru Matsuda
Prevention of hypoxic liver cell necrosis by in vivo human bcl-2 gene transfection.
Biochemical and biophysical research communications 1998;243(1):217-23.
1998: Shigeomi Shimizu; Yoshihide Tsujimoto
[Molecular mechanism of apoptosis].
Seikagaku. The Journal of Japanese Biochemical Society 1998;70(1):14-21.
1997: Makoto Ohtsu; N Sakai; Hisakazu Fujita; M Kashiwagi; S Gasa; Shigeomi Shimizu; Y Eguchi; Yoshihide Tsujimoto; Y Sakiyama; K Kobayashi; Noboru Kuzumaki
Inhibition of apoptosis by the actin-regulatory protein gelsolin.
The EMBO journal 1997;16(15):4650-6.
1997: Y Eguchi; Shigeomi Shimizu; Yoshihide Tsujimoto
[Molecular biology of apoptosis].
Rinsho byori. The Japanese journal of clinical pathology 1997;45(5):470-6.
1997: Yoshihide Tsujimoto; Shigeomi Shimizu; Y Eguchi; Wataru Kamiike; Hikaru Matsuda
Bcl-2 and Bcl-xL block apoptosis as well as necrosis: possible involvement of common mediators in apoptotic and necrotic signal transduction pathways.
Leukemia 1997;11 Suppl 3():380-2.
1997: K Yamabe; Wataru Kamiike; Shigeomi Shimizu; Satoshi Waguri; J Hasegawa; S Okuno; Yasuo Yoshioka; Yoshiki Sawa; Yasuo Uchiyama; Hikaru Matsuda
Prevention of hypoxic liver injury by in vivo transfection of the human bcl-2 gene.
Transplantation proceedings 1997;29(1-2):384-5.
1996: Shigeomi Shimizu; Y Eguchi; Wataru Kamiike; Y Akao; H Kosaka; J Hasegawa; H Matsuda; Yoshihide Tsujimoto
Involvement of ICE family proteases in apoptosis induced by reoxygenation of hypoxic hepatocytes.
The American journal of physiology 1996;271(6 Pt 1):G949-58.
1996: Y Morimoto; Wataru Kamiike; Toshirou Nishida; N Hatanaka; Shigeomi Shimizu; T P Huang; E Hamada; Yasuo Uchiyama; Y Yoshida; E Furuya; H Matsuda
Improvement of rat liver graft function by insulin administration to donor.
Gastroenterology 1996;111(4):1071-80.
1996: Shigeomi Shimizu; Y Eguchi; Wataru Kamiike; Satoshi Waguri; Yasuo Uchiyama; H Matsuda; Yoshihide Tsujimoto
Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors.
Oncogene 1996;13(1):21-9.
1996: Shigeomi Shimizu; Y Eguchi; Wataru Kamiike; H Matsuda; Yoshihide Tsujimoto
Bcl-2 expression prevents activation of the ICE protease cascade.
Oncogene 1996;12(11):2251-7.
1996: Shigeomi Shimizu; Y Eguchi; Wataru Kamiike; Satoshi Waguri; Yasuo Uchiyama; H Matsuda; Yoshihide Tsujimoto
Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible involvement of common mediators in apoptotic and necrotic signal transductions.
Oncogene 1996;12(10):2045-50.
1996: Shigeomi Shimizu; Y Eguchi; Wataru Kamiike; Y Itoh; J Hasegawa; K Yamabe; Y Otsuki; H Matsuda; Yoshihide Tsujimoto
Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL.
Cancer research 1996;56(9):2161-6.
1996: J Hasegawa; Sayo Kamada; Wataru Kamiike; Shigeomi Shimizu; Tomonari Imazu; H Matsuda; Yoshihide Tsujimoto
Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis.
Cancer research 1996;56(8):1713-8.
1996: Wataru Kamiike; Shigeomi Shimizu; Y Eguchi; J Hasegawa; K Yamabe; S Okuno; Yoshihide Tsujimoto; H Matsuda
Involvement of ICE-like proteases in hypoxic cell death.
Transplantation proceedings 1996;28(2):1106-7.
1995: N Hatanaka; W Kamike; Shigeomi Shimizu; M Miyata; T Inoue; Y Yoshida; K Tagawa; H Matsuda
Ca2+ release from mitochondria induces cytosolic enzyme leakage in anoxic liver.
The Journal of surgical research 1995;58(5):485-90.
1995: Shigeomi Shimizu; Y Eguchi; H Kosaka; Wataru Kamiike; H Matsuda; Yoshihide Tsujimoto
Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL.
Nature 1995;374(6525):811-3.
1995: Y Morimoto; Wataru Kamiike; N Hatanaka; Toshirou Nishida; Shigeomi Shimizu; Y Yoshida; H Matsuda
Enhancement of glycolysis in preserved rat liver: correlation between insulin procurement and phosphofructo-1-kinase activity.
Transplantation proceedings 1995;27(1):745-6.
1995: Wataru Kamiike; Shigeomi Shimizu; N Hatanaka; Y Morimoto; Toshirou Nishida; M Miyata; Y Yoshida; H Matsuda
Effect of intracellular pH on reoxygenation-induced mitochondrial damage.
Transplantation proceedings 1995;27(1):531-2.
1994: M Fujikawa; Wataru Kamiike; N Hatanaka; Shigeomi Shimizu; A Akashi; M Miyata; K Kurosawa; Y Yoshida; K Tagawa; H Matsuda
Changes in biliary glutathione level during ischemia-reperfusion of rat liver.
The Journal of surgical research 1994;57(5):569-73.
1994: N Hatanaka; Wataru Kamiike; Y Morimoto; Shigeomi Shimizu; M Miyata; Y Yoshida; H Matsuda
Protective effects of feeding and of fructose against hypoxic damage in the perfused liver.
Transplantation proceedings 1994;26(2):916-7.
1994: Wataru Kamiike; Shigeomi Shimizu; N Hatanaka; Y Morimoto; M Miyata; Y Yoshida; H Matsuda
Hypoxia-reoxygenation causes DNA damage in hepatocytes.
Transplantation proceedings 1994;26(2):907-9.
1993: Ryota Shirakura; Wataru Kamiike; A Matsumura; Shuji Miyagawa; Norihide Fukushima; N Hatanaka; J C Chang; Shigeomi Shimizu; H Sueki; A Amemiya
Multiorgan procurement from non-heart-beating donors by use of Osaka University cocktail, Osaka rinse solution, and the portable cardiopulmonary bypass machine.
Transplantation proceedings 1993;25(6):3093-4.
1992: N Hatanaka; Wataru Kamiike; Shigeomi Shimizu; M Miyata; T Inoue; K Tagawa; H Matsuda
Ischemic liver injury induced by calcium released from mitochondria.
Transplantation proceedings 1992;24(4):1620-2.