Takao Shimizu

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Ikeda Kazutaka; Oike Yuichi; Shimizu Takao; Taguchi Ryo
Global analysis of triacylglycerols including oxidized molecular species by reverse-phase high resolution LC/ESI-QTOF MS/MS.
Shindou Hideo; Eto Miki; Morimoto Ryo; Shimizu Takao
Identification of membrane O-acyltransferase family motifs.
Yasuda Daisuke; Okuno Toshiaki; Yokomizo Takehiko; Hori Tetsuya; Hirota Nobuaki; Hashidate Tomomi; Miyano Masashi; Shimizu Takao; Nakamura Motonao
Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum.

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All Publications

2009: Ikeda Kazutaka; Oike Yuichi; Shimizu Takao; Taguchi Ryo
Global analysis of triacylglycerols including oxidized molecular species by reverse-phase high resolution LC/ESI-QTOF MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(25):2639-47.
2009: Shindou Hideo; Eto Miki; Morimoto Ryo; Shimizu Takao
Identification of membrane O-acyltransferase family motifs.
Biochemical and biophysical research communications 2009;383(3):320-5.
2009: Yasuda Daisuke; Okuno Toshiaki; Yokomizo Takehiko; Hori Tetsuya; Hirota Nobuaki; Hashidate Tomomi; Miyano Masashi; Shimizu Takao; Nakamura Motonao
Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(5):1470-81.
2009: Yuki Koichi; Shindou Hideo; Hishikawa Daisuke; Shimizu Takao
Characterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual functions in the testis.
Journal of lipid research 2009;50(5):860-9.
2009: Nakanishi Hiroki; Iida Yasuhiro; Shimizu Takao; Taguchi Ryo
Analysis of oxidized phosphatidylcholines as markers for oxidative stress, using multiple reaction monitoring with theoretically expanded data sets with reversed-phase liquid chromatography/tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(13):1366-74.
2009: Shindou Hideo; Hishikawa Daisuke; Harayama Takeshi; Yuki Koichi; Shimizu Takao
Recent progress on acyl CoA: lysophospholipid acyltransferase research.
Journal of lipid research 2009;50 Suppl():S46-51.
2009: Shindou Hideo; Shimizu Takao
Acyl-CoA:lysophospholipid acyltransferases.
The Journal of biological chemistry 2009;284(1):1-5.
2009: Shimizu Takao
Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation.
Annual review of pharmacology and toxicology 2009;49():123-50.
2008: Li Yuehong; Yamada Hideomi; Kita Yoshihiro; Suzuki Masashi; Endo Yoko; Horita Shoko; Yamazaki Osamu; Shimizu Takao; Seki George; Fujita Toshiro
Arachidonic acid metabolites inhibit the stimulatory effect of angiotensin II in renal proximal tubules.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(12):2155-64.
2008: Ikeda Kazutaka; Shimizu Takao; Taguchi Ryo
Targeted analysis of ganglioside and sulfatide molecular species by LC/ESI-MS/MS with theoretically expanded multiple reaction monitoring.
Journal of lipid research 2008;49(12):2678-89.
2008: Kihara Yasuyuki; Yanagida Keisuke; Masago Kayo; Kita Yoshihiro; Hishikawa Daisuke; Shindou Hideo; Ishii Satoshi; Shimizu Takao
Platelet-activating factor production in the spinal cord of experimental allergic encephalomyelitis mice via the group IVA cytosolic phospholipase A2-lyso-PAFAT axis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):5008-14.
2008: Uozumi Naonori; Kita Yoshihiro; Shimizu Takao
Modulation of lipid and protein mediators of inflammation by cytosolic phospholipase A2alpha during experimental sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):3558-66.
2008: Hase Momoko; Yokomizo Takehiko; Shimizu Takao; Nakamura Motonao
Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins.
The Journal of biological chemistry 2008;283(19):12747-55.
2008: Okuno Toshiaki; Iizuka Yoshiko; Okazaki Hiroshi; Yokomizo Takehiko; Taguchi Ryo; Shimizu Takao
12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2.
The Journal of experimental medicine 2008;205(4):759-66.
2008: Tsujimura Yusuke; Obata Kazushige; Mukai Kaori; Shindou Hideo; Yoshida Masayuki; Nishikado Hideto; Kawano Yohei; Minegishi Yoshiyuki; Shimizu Takao; Karasuyama Hajime
Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis.
Immunity 2008;28(4):581-9.
2008: Harayama Takeshi; Shindou Hideo; Ogasawara Rie; Suwabe Akira; Shimizu Takao
Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor.
The Journal of biological chemistry 2008;283(17):11097-106.
2008: Hikiji Hisako; Takato Tsuyoshi; Shimizu Takao; Ishii Satoshi
The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease.
Progress in lipid research 2008;47(2):107-26.
2008: Hishikawa Daisuke; Shindou Hideo; Kobayashi Saori; Nakanishi Hiroki; Taguchi Ryo; Shimizu Takao
Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):2830-5.
2008: Li Yuehong; Yamada Hideomi; Kita Yoshihiro; Kunimi Motoei; Horita Shoko; Suzuki Masashi; Endo Yoko; Shimizu Takao; Seki George; Fujita Toshiro
Roles of ERK and cPLA2 in the angiotensin II-mediated biphasic regulation of Na+-HCO3(-) transport.
Journal of the American Society of Nephrology : JASN 2008;19(2):252-9.
2007: Kimura Masafumi; Taniguchi Masahiko; Mikami Yoshinori; Masuda Tomoyuki; Yoshida Tomoyuki; Mishina Masayoshi; Shimizu Takao
Identification and characterization of zebrafish semaphorin 6D.
Biochemical and biophysical research communications 2007;363(3):762-8.
2007: Shindou Hideo; Hishikawa Daisuke; Nakanishi Hiroki; Harayama Takeshi; Ishii Satoshi; Taguchi Ryo; Shimizu Takao
A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase.
The Journal of biological chemistry 2007;282(9):6532-9.
2007: Yanagida Keisuke; Ishii Satoshi; Hamano Fumie; Noguchi Kyoko; Shimizu Takao
LPA4/p2y9/GPR23 mediates rho-dependent morphological changes in a rat neuronal cell line.
The Journal of biological chemistry 2007;282(8):5814-24.
2007: Kuniyeda Kanako; Okuno Toshiaki; Terawaki Kan; Miyano Masashi; Yokomizo Takehiko; Shimizu Takao
Identification of the intracellular region of the leukotriene B4 receptor type 1 that is specifically involved in Gi activation.
The Journal of biological chemistry 2007;282(6):3998-4006.
2007: Taguchi Ryo; Nishijima Mashahiro; Shimizu Takao
Basic analytical systems for lipidomics by mass spectrometry in Japan.
Methods in enzymology 2007;432():185-211.
2006: Kita Yoshihiro; Ohto Takayo; Uozumi Naonori; Shimizu Takao
Biochemical properties and pathophysiological roles of cytosolic phospholipase A2s.
Biochimica et biophysica acta 2006;1761(11):1317-22.
2006: Hori Tetsuya; Ishijima Jun; Yokomizo Takehiko; Ago Hideo; Shimizu Takao; Miyano Masashi
Crystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex reveals the structural basis of broad spectrum indomethacin efficacy.
Journal of biochemistry 2006;140(3):457-66.
2006: Nakanishi Hiroki; Shindou Hideo; Hishikawa Daisuke; Harayama Takeshi; Ogasawara Rie; Suwabe Akira; Taguchi Ryo; Shimizu Takao
Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production.
The Journal of biological chemistry 2006;281(29):20140-7.
2006: Shimizu Takao; Ohto Takayo; Kita Yoshihiro
Cytosolic phospholipase A2: biochemical properties and physiological roles.
IUBMB life 2006;58(5-6):328-33.
2006: Doi Kent; Okamoto Koji; Negishi Kousuke; Suzuki Yoshifumi; Nakao Akihide; Fujita Toshiro; Toda Akiko; Yokomizo Takehiko; Kita Yoshihiro; Kihara Yasuyuki; Ishii Satoshi; Shimizu Takao; Noiri Eisei
Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice.
The American journal of pathology 2006;168(5):1413-24.
2006: Yoshikawa Keisuke; Kita Yoshihiro; Kishimoto Koji; Shimizu Takao
Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure: dual phase regulation and differential involvement of COX-1 and COX-2.
The Journal of biological chemistry 2006;281(21):14663-9.
2005: Terawaki Kan; Yokomizo Takehiko; Nagase Takahide; Toda Akiko; Taniguchi Masahiko; Hashizume Kohei; Yagi Takeshi; Shimizu Takao
Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2-type immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4217-25.
2005: Kihara Yasuyuki; Ishii Satoshi; Kita Yoshihiro; Toda Akiko; Shimada Atsuyoshi; Shimizu Takao
Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor.
The Journal of experimental medicine 2005;202(6):853-63.
2005: Okuno Toshiaki; Yokomizo Takehiko; Hori Tetsuya; Miyano Masashi; Shimizu Takao
Leukotriene B4 receptor and the function of its helix 8.
The Journal of biological chemistry 2005;280(37):32049-52.
2005: Taniguchi Masahiko; Masuda Tomoyuki; Fukaya Masahiro; Kataoka Hirotaka; Mishina Masayoshi; Yaginuma Hiroyuki; Watanabe Masahiko; Shimizu Takao
Identification and characterization of a novel member of murine semaphorin family.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(8):785-92.
2005: Taguchi Ryo; Houjou Toshiaki; Nakanishi Hiroki; Yamazaki Toshiyuki; Ishida Mayuko; Imagawa Masayoshi; Shimizu Takao
Focused lipidomics by tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;823(1):26-36.
2005: Shindou Hideo; Ishii Satoshi; Yamamoto Masahiro; Takeda Kiyoshi; Akira Shizuo; Shimizu Takao
Priming effect of lipopolysaccharide on acetyl-coenzyme A:lyso-platelet-activating factor acetyltransferase is MyD88 and TRIF independent.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):1177-83.
2005: Kita Yoshihiro; Takahashi Toshie; Uozumi Naonori; Shimizu Takao
A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry.
Analytical biochemistry 2005;342(1):134-43.
2005: Iizuka Yoshiko; Yokomizo Takehiko; Terawaki Kan; Komine Mayumi; Tamaki Kunihiko; Shimizu Takao
Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes.
The Journal of biological chemistry 2005;280(26):24816-23.
2005: Ohto Takayo; Uozumi Naonori; Hirabayashi Tetsuya; Shimizu Takao
Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}.
The Journal of biological chemistry 2005;280(26):24576-83.
2005: Kita Yoshihiro; Takahashi Toshie; Uozumi Naonori; Nallan Laxman; Gelb Michael H; Shimizu Takao
Pathway-oriented profiling of lipid mediators in macrophages.
Biochemical and biophysical research communications 2005;330(3):898-906.
2005: Ishii Satoshi; Kihara Yasuyuki; Shimizu Takao
Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor.
The Journal of biological chemistry 2005;280(10):9083-7.
2005: Houjou Toshiaki; Yamatani Kotoko; Imagawa Masayoshi; Shimizu Takao; Taguchi Ryo
A shotgun tandem mass spectrometric analysis of phospholipids with normal-phase and/or reverse-phase liquid chromatography/electrospray ionization mass spectrometry.
Rapid communications in mass spectrometry : RCM 2005;19(5):654-66.
2004: Murakami Naoka; Yokomizo Takehiko; Okuno Toshiaki; Shimizu Takao
G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine.
The Journal of biological chemistry 2004;279(41):42484-91.
2004: Hikiji Hisako; Ishii Satoshi; Shindou Hideo; Takato Tsuyoshi; Shimizu Takao
Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy.
The Journal of clinical investigation 2004;114(1):85-93.
2004: Ishikawa Shumpei; Uozumi Naonori; Shiibashi Takashi; Izumi Takashi; Fukayama Masashi; Shimizu Takao; Watanabe Junichi; Nogami Sadao
Short report: Lethal malaria in cytosolic phospholipase A2- and phospholipase A2IIA-deficient mice.
The American journal of tropical medicine and hygiene 2004;70(6):645-50.
2004: Ishii Satoshi; Nagase Takahide; Shindou Hideo; Takizawa Hajime; Ouchi Yasuyoshi; Shimizu Takao
Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):7095-102.
2004: Hori Tetsuya; Yokomizo Takehiko; Ago Hideo; Sugahara Mitsuaki; Ueno Go; Yamamoto Masaki; Kumasaka Takashi; Shimizu Takao; Miyano Masashi
Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-Oxo-prostaglandin 13-reductase catalytic mechanism and a possible Src homology 3 domain binding loop.
The Journal of biological chemistry 2004;279(21):22615-23.
2004: Taniguchi Masahiko; Shimizu Takao
Characterization of a novel member of murine semaphorin family.
Biochemical and biophysical research communications 2004;314(1):242-8.
2004: Houjou Toshiaki; Yamatani Kotoko; Nakanishi Hiroki; Imagawa Masayoshi; Shimizu Takao; Taguchi Ryo
Rapid and selective identification of molecular species in phosphatidylcholine and sphingomyelin by conditional neutral loss scanning and MS3.
Rapid communications in mass spectrometry : RCM 2004;18(24):3123-30.
2003: Okuno Toshiaki; Ago Hideo; Terawaki Kan; Miyano Masashi; Shimizu Takao; Yokomizo Takehiko
Helix 8 of the leukotriene B4 receptor is required for the conformational change to the low affinity state after G-protein activation.
The Journal of biological chemistry 2003;278(42):41500-9.
2003: Tokuoka Suzumi M; Ishii Satoshi; Kawamura Noriko; Satoh Mamoru; Shimada Atsuyoshi; Sasaki Shinji; Hirotsune Shinji; Wynshaw-Boris Anthony; Shimizu Takao
Involvement of platelet-activating factor and LIS1 in neuronal migration.
The European journal of neuroscience 2003;18(3):563-70.
2003: Noguchi Kyoko; Ishii Satoshi; Shimizu Takao
Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.
The Journal of biological chemistry 2003;278(28):25600-6.
2003: Masuda Kazuyuki; Itoh Hiroshi; Sakihama Toshiko; Akiyama Chiyuki; Takahashi Kazuaki; Fukuda Rie; Yokomizo Takehiko; Shimizu Takao; Kodama Tatsuhiko; Hamakubo Takao
A combinatorial G protein-coupled receptor reconstitution system on budded baculovirus. Evidence for Galpha and Galphao coupling to a human leukotriene B4 receptor.
The Journal of biological chemistry 2003;278(27):24552-62.
2003: Yamauchi Toshimasa; Kamon Junji; Ito Yusuke; Tsuchida Atsushi; Yokomizo Takehiko; Kita Shunbun; Sugiyama Takuya; Miyagishi Makoto; Hara Kazuo; Tsunoda Masaki; Murakami Koji; Ohteki Toshiaki; Uchida Shoko; Takekawa Sato; Waki Hironori; Tsuno Nelson H; Shibata Yoichi; Terauchi Yasuo; Froguel Philippe; Tobe Kazuyuki; Koyasu Shigeo; Taira Kazunari; Kitamura Toshio; Shimizu Takao; Nagai Ryozo; Kadowaki Takashi
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.
Nature 2003;423(6941):762-9.
2003: Miyaura Chisato; Inada Masaki; Matsumoto Chiho; Ohshiba Tomoyasu; Uozumi Naonori; Shimizu Takao; Ito Akira
An essential role of cytosolic phospholipase A2alpha in prostaglandin E2-mediated bone resorption associated with inflammation.
The Journal of experimental medicine 2003;197(10):1303-10.
2003: Hegen Martin; Sun Linhong; Uozumi Naonori; Kume Kazuhiko; Goad Mary E; Nickerson-Nutter Cheryl L; Shimizu Takao; Clark James D
Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis.
The Journal of experimental medicine 2003;197(10):1297-302.
2003: Nagase Takahide; Uozumi Naonori; Aoki-Nagase Tomoko; Terawaki Kan; Ishii Satoshi; Tomita Tetsuji; Yamamoto Hiroshi; Hashizume Kohei; Ouchi Yasuyoshi; Shimizu Takao
A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice.
American journal of physiology. Lung cellular and molecular physiology 2003;284(5):L720-6.
2003: Asai Kenji; Hirabayashi Tetsuya; Houjou Toshiaki; Uozumi Naonori; Taguchi Ryo; Shimizu Takao
Human group IVC phospholipase A2 (cPLA2gamma). Roles in the membrane remodeling and activation induced by oxidative stress.
The Journal of biological chemistry 2003;278(10):8809-14.
2003: Taniguchi Masahiko; Nagao Hiroshi; Takahashi Yuji K; Yamaguchi Masahiro; Mitsui Sachiko; Yagi Takeshi; Mori Kensaku; Shimizu Takao
Distorted odor maps in the olfactory bulb of semaphorin 3A-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(4):1390-7.
2003: Usui Hiroshi; Taniguchi Masahiko; Yokomizo Takehiko; Shimizu Takao
Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains.
Biochemical and biophysical research communications 2003;300(4):927-31.
2002: Ito Nobuko; Yokomizo Takehiko; Sasaki Takehiko; Kurosu Hiroshi; Penninger Josef; Kanaho Yasunori; Katada Toshiaki; Hanaoka Kazuo; Shimizu Takao
Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release.
The Journal of biological chemistry 2002;277(47):44898-904.
2002: Ishii Satoshi; Nagase Takahide; Shimizu Takao
Platelet-activating factor receptor.
Prostaglandins & other lipid mediators 2002;68-69():599-609.
2002: Toda Akiko; Yokomizo Takehiko; Shimizu Takao
Leukotriene B4 receptors.
Prostaglandins & other lipid mediators 2002;68-69():575-85.
2002: Uozumi Naonori; Shimizu Takao
Roles for cytosolic phospholipase A2alpha as revealed by gene-targeted mice.
Prostaglandins & other lipid mediators 2002;68-69():59-69.
2002: Wong Dennis A; Kita Yoshihiro; Uozumi Naonori; Shimizu Takao
Discrete role for cytosolic phospholipase A(2)alpha in platelets: studies using single and double mutant mice of cytosolic and group IIA secretory phospholipase A(2).
The Journal of experimental medicine 2002;196(3):349-57.
2002: Honda Zen-ichiro; Ishii Satoshi; Shimizu Takao
Platelet-activating factor receptor.
Journal of biochemistry 2002;131(6):773-9.
2002: Nagase Takahide; Uozumi Naonori; Ishii Satoshi; Kita Yoshihiro; Yamamoto Hiroshi; Ohga Eijiro; Ouchi Yasuyoshi; Shimizu Takao
A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis.
Nature medicine 2002;8(5):480-4.
2002: Ogasawara Hideaki; Ishii Satoshi; Yokomizo Takehiko; Kakinuma Takashi; Komine Mayumi; Tamaki Kunihiko; Shimizu Takao; Izumi Takashi
Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2: differential pharmacological properties and tissue distribution.
The Journal of biological chemistry 2002;277(21):18763-8.
2002: Ohshima Noriyasu; Ishii Satoshi; Izumi Takashi; Shimizu Takao
Receptor-dependent metabolism of platelet-activating factor in murine macrophages.
The Journal of biological chemistry 2002;277(12):9722-7.
2002: Nagase Takahide; Ishii Satishi; Shindou Hideo; Ouchi Yasuyoshi; Shimizu Takao
Airway hyperresponsiveness in transgenic mice overexpressing platelet activating factor receptor is mediated by an atropine-sensitive pathway.
American journal of respiratory and critical care medicine 2002;165(2):200-5.
2002: Yokomizo Takehiko; Noiri Eisei; Izumi Takashi; Shimizu Takao
In vivo chemotaxis using CHO cells expressing human leukotriene B4 receptor.
Advances in experimental medicine and biology 2002;507():357-61.
2001: Takahashi T; Sugishita Y; Kinugawa K; Shimizu T; Yao A; Harada K; Matsui H; Nagai R
Ets-1 is involved in transcriptional regulation of the chick inducible nitric oxide synthase gene in embryonic ventricular myocytes.
Molecular and cellular biochemistry 2001;226(1-2):57-65.
2001: Harada K; Shimizu T; Sugishita Y; Yao A; Suzuki J; Takenaka K; Hirata Y; Nagai R; Takahashi T
Hypertrophic cardiomyopathy with midventricular obstruction and apical aneurysm: a case report.
Japanese circulation journal 2001;65(10):915-9.
2001: Harada K; Sugishita Y; Shimizu T; Yao A; Matsui H; Kohmoto O; Serizawa T; Nagai R; Takahashi T
Left ventricular relaxation abnormality is detectable by analysis of the relaxation time constant in patients with atrial fibrillation.
Japanese circulation journal 2001;65(7):610-6.
2001: Yokomizo T; Izumi T; Shimizu T
Co-expression of two LTB4 receptors in human mononuclear cells.
Life sciences 2001;68(19-20):2207-12.
2001: Yokomizo T; Kato K; Hagiya H; Izumi T; Shimizu T
Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2.
The Journal of biological chemistry 2001;276(15):12454-9.
2001: Takahashi T; Sugishita Y; Nojiri T; Shimizu T; Yao A; Kinugawa K; Harada K; Nagai R
Cloning of hypoxia-inducible factor 1alpha cDNA from chick embryonic ventricular myocytes.
Biochemical and biophysical research communications 2001;281(4):1057-62.
2001: Yokomizo T; Izumi T; Shimizu T
Leukotriene B4: metabolism and signal transduction.
Archives of biochemistry and biophysics 2001;385(2):231-41.
2000: Nakatani N; Uozumi N; Kume K; Murakami M; Kudo I; Shimizu T
Role of cytosolic phospholipase A2 in the production of lipid mediators and histamine release in mouse bone-marrow-derived mast cells.
The Biochemical journal 2000;352 Pt 2():311-7.
2000: Takaku K; Sonoshita M; Sasaki N; Uozumi N; Doi Y; Shimizu T; Taketo M M
Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene.
The Journal of biological chemistry 2000;275(44):34013-6.
2000: Hirabayashi T; Shimizu T
Localization and regulation of cytosolic phospholipase A(2).
Biochimica et biophysica acta 2000;1488(1-2):124-38.
2000: Kawasawa Y; Kume K; Izumi T; Shimizu T
Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems.
Biochemical and biophysical research communications 2000;276(3):957-64.
2000: Kawasawa Y; Kume K; Nakade S; Haga H; Izumi T; Shimizu T
Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45.
Biochemical and biophysical research communications 2000;276(3):952-6.
2000: Yokomizo T; Kato K; Terawaki K; Izumi T; Shimizu T
A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.
The Journal of experimental medicine 2000;192(3):421-32.
2000: Kato K; Yokomizo T; Izumi T; Shimizu T
Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene.
The Journal of experimental medicine 2000;192(3):413-20.
2000: Sugishita Y; Takahashi T; Shimizu T; Yao A; Kinugawa K; Sugishita K; Harada K; Matsui H; Nagai R
Expression of genes encoding vascular endothelial growth factor and its Flk-1 receptor in the chick embryonic heart.
Journal of molecular and cellular cardiology 2000;32(6):1039-51.
2000: Aihara M; Ishii S; Kume K; Shimizu T
Interaction between neurone and microglia mediated by platelet-activating factor.
Genes to cells : devoted to molecular & cellular mechanisms 2000;5(5):397-406.
2000: Shindou H; Ishii S; Uozumi N; Shimizu T
Roles of cytosolic phospholipase A(2) and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF.
Biochemical and biophysical research communications 2000;271(3):812-7.
2000: Sugishita Y; Shimizu T; Yao A; Kinugawa K i; Nojiri T; Harada K; Matsui H; Nagai R; Takahashi T
Lipopolysaccharide augments expression and secretion of vascular endothelial growth factor in rat ventricular myocytes.
Biochemical and biophysical research communications 2000;268(2):657-62.
2000: Yokomizo T; Masuda K; Kato K; Toda A; Izumi T; Shimizu T
Leukotriene B4 receptor. Cloning and intracellular signaling.
American journal of respiratory and critical care medicine 2000;161(2 Pt 2):S51-5.
2000: Ishii S; Shimizu T
Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice.
Progress in lipid research 2000;39(1):41-82.
2000: Noiri E; Yokomizo T; Nakao A; Izumi T; Fujita T; Kimura S; Shimizu T
An in vivo approach showing the chemotactic activity of leukotriene B(4) in acute renal ischemic-reperfusion injury.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):823-8.
2000: Shimizu T; Yokomizo T; Izumi T
Leukotriene-B4 receptor and signal transduction.
Ernst Schering Research Foundation workshop 2000;(31):125-41.
1999: Ishizaka N; Nakao A; Ohishi N; Suzuki M; Aizawa T; Taguchi J; Nagai R; Shimizu T; Ohno M
Increased leukotriene A(4) hydrolase expression in the heart of angiotensin II-induced hypertensive rat.
FEBS letters 1999;463(1-2):155-9.
1999: Sato S; Kume K; Ito C; Ishii S; Shimizu T
Accelerated proliferation of epidermal keratinocytes by the transgenic expression of the platelet-activating factor receptor.
Archives of dermatological research 1999;291(11):614-21.
1999: Nagase T; Ishii S; Kume K; Uozumi N; Izumi T; Ouchi Y; Shimizu T
Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice.
The Journal of clinical investigation 1999;104(8):1071-6.
1999: Boie Y; Stocco R; Sawyer N; Greig G M; Kargman S; Slipetz D M; O'Neill G P; Shimizu T; Yokomizo T; Metters K M; Abramovitz M
Characterization of the cloned guinea pig leukotriene B4 receptor: comparison to its human orthologue.
European journal of pharmacology 1999;380(2-3):203-13.
1999: Toda A; Yokomizo T; Masuda K; Nakao A; Izumi T; Shimizu T
Cloning and characterization of rat leukotriene B(4) receptor.
Biochemical and biophysical research communications 1999;262(3):806-12.
1999: Masuda K; Yokomizo T; Izumi T; Shimizu T
cDNA cloning and characterization of guinea-pig leukotriene B4 receptor.
The Biochemical journal 1999;342 ( Pt 1)():79-85.
1999: Sugishita K; Kinugawa K; Shimizu T; Harada K; Matsui H; Takahashi T; Serizawa T; Kohmoto O
Cellular basis for the acute inhibitory effects of IL-6 and TNF- alpha on excitation-contraction coupling.
Journal of molecular and cellular cardiology 1999;31(8):1457-67.
1999: Sugishita Y; Tajima S; Shimizu T; Sugishita K; Harada K; Matsui H; Inoue M; Murakawa Y; Suzuki J; Takenaka K; Omata M; Takahashi T
An adult case with an abnormal right ventricular structure causing intraventricular pressure gradient and a history of aphthous stomatitis and thrombophlebitis.
Japanese heart journal 1999;40(4):517-25.
1999: Ishii S; Shimizu T
[Platelet-activating factor (PAF) receptor-related pathophysiology]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(8 Suppl):1068-74.
1999: Kobayashi K; Ishii S; Kume K; Takahashi T; Shimizu T; Manabe T
Platelet-activating factor receptor is not required for long-term potentiation in the hippocampal CA1 region.
The European journal of neuroscience 1999;11(4):1313-6.
1999: Shimizu T; Kinugawa K; Yao A; Sugishita Y; Sugishita K; Harada K; Matsui H; Kohmoto O; Serizawa T; Takahashi T
Platelet-derived growth factor induces cellular growth in cultured chick ventricular myocytes.
Cardiovascular research 1999;41(3):641-53.
1999: Hirabayashi T; Kume K; Hirose K; Yokomizo T; Iino M; Itoh H; Shimizu T
Critical duration of intracellular Ca2+ response required for continuous translocation and activation of cytosolic phospholipase A2.
The Journal of biological chemistry 1999;274(8):5163-9.
1999: Igarashi T; Yokomizo T; Tsutsumi O; Taketani Y; Shimizu T; Izumi T
Characterization of the leukotriene B4 receptor in porcine leukocytes. Separation and reconstitution with heterotrimeric GTP-binding proteins.
European journal of biochemistry / FEBS 1999;259(1-2):419-25.
1999: Nakao A; Watanabe T; Ohishi N; Toda A; Asano K; Taniguchi S; Nosaka K; Noiri E; Suzuki T; Sakai T; Kurokawa K; Shimizu T; Kimura S
Ubiquitous localization of leukotriene A4 hydrolase in the rat nephron.
Kidney international 1999;55(1):100-8.
1999: Izumi T; Yokomizo T; Igarashi T; Shimizu T
Molecular cloning and characterization of leukotriene B4 receptor.
Advances in experimental medicine and biology 1999;469():237-44.
1998: Kinoshita S; Suzuki H; Ito K; Kume K; Shimizu T; Sugiyama Y
Transfected rat cMOAT is functionally expressed on the apical membrane in Madin-Darby canine kidney (MDCK) cells.
Pharmaceutical research 1998;15(12):1851-6.
1998: Hirabayashi T; Kume K; Shimizu T
Conditional expression of the dual-specificity phosphatase PYST1/MKP-3 inhibits phosphorylation of cytosolic phospholipase A2 in Chinese hamster ovary cells.
Biochemical and biophysical research communications 1998;253(2):485-8.
1998: Suzuki Y; Tanokura M; Shimizu T
Evidence for existence of multiple conformations of kinesin and ncd motor domains in solution revealed by 31P-NMR of the tightly bound ADP.
European journal of biochemistry / FEBS 1998;257(2):466-71.
1998: Ishii S; Kuwaki T; Nagase T; Maki K; Tashiro F; Sunaga S; Cao W H; Kume K; Fukuchi Y; Ikuta K; Miyazaki J; Kumada M; Shimizu T
Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor.
The Journal of experimental medicine 1998;187(11):1779-88.
1998: Shimizu T; Kinugawa K; Sugishita Y; Sugishita K; Harada K; Matsui H; Kohmoto O; Serizawa T; Takahashi T
Molecular cloning and expression of inducible nitric oxide synthase in chick embryonic ventricular myocytes.
Cardiovascular research 1998;38(2):405-13.
1998: Ishii I; Saito E; Izumi T; Ui M; Shimizu T
Agonist-induced sequestration, recycling, and resensitization of platelet-activating factor receptor. Role of cytoplasmic tail phosphorylation in each process.
The Journal of biological chemistry 1998;273(16):9878-85.
1998: Hoshino M; Izumi T; Shimizu T
Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells.
The Journal of biological chemistry 1998;273(9):4878-82.
1998: Nagoshi H; Uehara Y; Kanai F; Maeda S; Ogura T; Goto A; Toyo-oka T; Esumi H; Shimizu T; Omata M
Prostaglandin D2 inhibits inducible nitric oxide synthase expression in rat vascular smooth muscle cells.
Circulation research 1998;82(2):204-9.
1998: Ito K; Suzuki H; Hirohashi T; Kume K; Shimizu T; Sugiyama Y
Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver.
The Journal of biological chemistry 1998;273(3):1684-8.
1997: Shimizu T; Fukagawa M; Kuroda T; Hata S; Iwasaki Y; Nemoto M; Shirai K; Yamauchi S; Margolin S B; Shimizu F; Kurokawa K
Pirfenidone prevents collagen accumulation in the remnant kidney in rats with partial nephrectomy.
Kidney international. Supplement 1997;63():S239-43.
1997: Nakao A; Nosaka K; Ohishi N; Noiri E; Suzuki T; Taniguchi S; Seki G; Watanabe T; Kurokawa K; Shimizu T; Kimura S
Long-term effects of LTB4 antagonist on lipid induced renal injury.
Kidney international. Supplement 1997;63():S236-8.
1997: Uozumi N; Kume K; Nagase T; Nakatani N; Ishii S; Tashiro F; Komagata Y; Maki K; Ikuta K; Ouchi Y; Miyazaki J; Shimizu T
Role of cytosolic phospholipase A2 in allergic response and parturition.
Nature 1997;390(6660):618-22.
1997: Kinugawa K; Shimizu T; Yao A; Kohmoto O; Serizawa T; Takahashi T
Transcriptional regulation of inducible nitric oxide synthase in cultured neonatal rat cardiac myocytes.
Circulation research 1997;81(6):911-21.
1997: Tabuchi S; Kume K; Aihara M; Ishii S; Mishina M; Shimizu T
Lipid mediators modulate NMDA receptor currents in a Xenopus oocyte expression system.
Neuroscience letters 1997;237(1):13-6.
1997: Mori M; Aihara M; Shimizu T
Localization of platelet-activating factor receptor messenger RNA in the rat eye.
Investigative ophthalmology & visual science 1997;38(12):2672-8.
1997: Nagase T; Ishii S; Katayama H; Fukuchi Y; Ouchi Y; Shimizu T
Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes.
American journal of respiratory and critical care medicine 1997;156(5):1621-7.
1997: Honda Z i; Suzuki T; Hirose N; Aihara M; Shimizu T; Nada S; Okada M; Ra C; Morita Y; Ito K
Roles of C-terminal Src kinase in the initiation and the termination of the high affinity IgE receptor-mediated signaling.
The Journal of biological chemistry 1997;272(41):25753-60.
1997: Nakao A; Watanabe T; Bitoh H; Imaki H; Suzuki T; Asano K; Taniguchi S; Nosaka K; Shimizu T; Kurokawa K
cAMP mediates homologous downregulation of PAF receptor mRNA expression in mesangial cells.
The American journal of physiology 1997;273(3 Pt 2):F445-50.
1997: Kume K; Shimizu T
Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor.
The Journal of biological chemistry 1997;272(36):22898-904.
1997: Kume K; Shimizu T
cDNA cloning and expression of murine 1-acyl-sn-glycerol-3-phosphate acyltransferase.
Biochemical and biophysical research communications 1997;237(3):663-6.
1997: Sugishita K; Shimizu T; Kinugawa K; Harada K; Ikenouchi H; Matsui H; Kohmoto O; Takahashi T; Omata M
Chronic total occlusion of the left main coronary artery.
Internal medicine (Tokyo, Japan) 1997;36(7):471-8.
1997: Suzuki Y; Shimizu T; Morii H; Tanokura M
Hydrolysis of AMPPNP by the motor domain of ncd, a kinesin-related protein.
FEBS letters 1997;409(1):29-32.
1997: Yokomizo T; Izumi T; Chang K; Takuwa Y; Shimizu T
A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis.
Nature 1997;387(6633):620-4.
1997: Ishii I; Izumi T; Tsukamoto H; Umeyama H; Ui M; Shimizu T
Alanine exchanges of polar amino acids in the transmembrane domains of a platelet-activating factor receptor generate both constitutively active and inactive mutants.
The Journal of biological chemistry 1997;272(12):7846-54.
1997: Kume K; Waga I; Shimizu T
Microplate chromatography assay for acetyl-CoA: lysoplatelet-activating factor acetyltransferase.
Analytical biochemistry 1997;246(1):118-22.
1997: Mori M; Aihara M; Shimizu T
Differential expression of somatostatin receptors in the rat eye: SSTR4 is intensely expressed in the iris/ciliary body.
Neuroscience letters 1997;223(3):185-8.
1997: Kohmoto O; Shimizu T; Sugishita K; Kinugawa K; Takahashi T; Serizawa T
Selectivity of felodipine for depolarized ventricular myocytes: a study at the single-cell level.
European journal of pharmacology 1997;319(2-3):355-63.
1997: Ogita T; Tanaka Y; Nakaoka T; Matsuoka R; Kira Y; Nakamura M; Shimizu T; Fujita T
Lysophosphatidylcholine transduces Ca2+ signaling via the platelet-activating factor receptor in macrophages.
The American journal of physiology 1997;272(1 Pt 2):H17-24.
1997: Ito K; Suzuki H; Hirohashi T; Kume K; Shimizu T; Sugiyama Y
Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR.
The American journal of physiology 1997;272(1 Pt 1):G16-22.
1997: Ishii S; Nagase T; Tashiro F; Ikuta K; Sato S; Waga I; Kume K; Miyazaki J; Shimizu T
Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor.
The EMBO journal 1997;16(1):133-42.
1997: Ishii I; Izumi T; Ui M; Shimizu T
High and low affinity mutants of platelet-activating factor receptor.
Advances in experimental medicine and biology 1997;433():249-53.
1997: Bito H; Shimizu T
Molecular characterization and physiological functions of PAF receptors.
Advances in experimental medicine and biology 1997;400A():215-21.
1997: Mori M; Aihara M; Kume K; Hamanoue M; Kohsaka S; Shimizu T
Localization of platelet-activating factor receptor in the rat brain.
Advances in experimental medicine and biology 1997;407():357-63.
1997: Ishii S; Nakamura M; Waga I; Kume K; Izumi T; Shimizu T
Cloning and characterization of a murine platelet-activating factor receptor gene.
Advances in experimental medicine and biology 1997;407():347-55.
1997: Shimizu T; Mutoh H
Structure and regulation of platelet activating factor receptor gene.
Advances in experimental medicine and biology 1997;407():197-204.
1997: Yokomizo T; Ogawa Y; Uozumi N; Kume K; Izumi T; Shimizu T
cDNA cloning and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase.
Advances in experimental medicine and biology 1997;407():151-6.

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