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T Shimizu

Research Profile

Physiology

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Co-Publications
Name
13
Ikuko Sagami
9
Simon Daff
3
H Sato
1
Paul R. Ortiz de Montellano

Publications

TOP 3
T Noguchi; Ikuko Sagami; Simon Daff; T Shimizu
Important role of tetrahydrobiopterin in no complex formation and interdomain electron transfer in neuronal nitric-oxide synthase.
Y Sato; Ikuko Sagami; T Matsui; T Shimizu
Unusual role of Tyr588 of neuronal nitric oxide synthase in controlling substrate specificity and electron transfer.
T Yumoto; Ikuko Sagami; Simon Daff; T Shimizu
Roles of the heme proximal side residues tryptophan409 and tryptophan421 of neuronal nitric oxide synthase in the electron transfer reaction.

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All Publications

2001: T Noguchi; Ikuko Sagami; Simon Daff; T Shimizu
Important role of tetrahydrobiopterin in no complex formation and interdomain electron transfer in neuronal nitric-oxide synthase.
Biochemical and biophysical research communications 2001;282(5):1092-7.
2001: Y Sato; Ikuko Sagami; T Matsui; T Shimizu
Unusual role of Tyr588 of neuronal nitric oxide synthase in controlling substrate specificity and electron transfer.
Biochemical and biophysical research communications 2001;281(3):621-6.
2000: T Yumoto; Ikuko Sagami; Simon Daff; T Shimizu
Roles of the heme proximal side residues tryptophan409 and tryptophan421 of neuronal nitric oxide synthase in the electron transfer reaction.
Journal of inorganic biochemistry 2000;82(1-4):163-70.
2000: Ikuko Sagami; Y Sato; Simon Daff; T Shimizu
Aromatic residues and neighboring Arg414 in the (6R)-5,6,7, 8-tetrahydro-L-biopterin binding site of full-length neuronal nitric-oxide synthase are crucial in catalysis and heme reduction with NADPH.
The Journal of biological chemistry 2000;275(34):26150-7.
1999: Simon Daff; Ikuko Sagami; T Shimizu
The 42-amino acid insert in the FMN domain of neuronal nitric-oxide synthase exerts control over Ca(2+)/calmodulin-dependent electron transfer.
The Journal of biological chemistry 1999;274(43):30589-95.
1999: T Shimanuki; H Sato; Simon Daff; Ikuko Sagami; T Shimizu
Crucial role of Lys(423) in the electron transfer of neuronal nitric-oxide synthase.
The Journal of biological chemistry 1999;274(38):26956-61.
1998: H Sato; Ikuko Sagami; Simon Daff; T Shimizu
Autoxidation rates of neuronal nitric oxide synthase: effects of the substrates, inhibitors, and modulators.
Biochemical and biophysical research communications 1998;253(3):845-9.
1998: K Yanagita; Ikuko Sagami; Simon Daff; T Shimizu
Marked enhancement in the reductive dehalogenation of hexachloroethane by a Thr319Ala mutation of cytochrome P450 1A2.
Biochemical and biophysical research communications 1998;249(3):678-82.
1998: K Nakano; Ikuko Sagami; Simon Daff; T Shimizu
Chiral recognition at the heme active site of nitric oxide synthase is markedly enhanced by L-arginine and 5,6,7,8-tetrahydrobiopterin.
Biochemical and biophysical research communications 1998;248(3):767-72.
1998: H Sato; S Nomura; Ikuko Sagami; O Ito; Simon Daff; T Shimizu
CO binding studies of nitric oxide synthase: effects of the substrate, inhibitors and tetrahydrobiopterin.
FEBS letters 1998;430(3):377-80.
1998: Ikuko Sagami; T Shimizu
The crucial roles of Asp-314 and Thr-315 in the catalytic activation of molecular oxygen by neuronal nitric-oxide synthase. A site-directed mutagenesis study.
The Journal of biological chemistry 1998;273(4):2105-8.
1997: Y Shibata; H Sato; Ikuko Sagami; T Shimizu
Interaction of Angeli's salt with cytochrome P450 1A2 distal mutants: an optical absorption spectral study.
Biochimica et biophysica acta 1997;1343(1):67-75.
1997: K Yanagita; Ikuko Sagami; T Shimizu
Distal site and surface mutations of cytochrome P450 1A2 markedly enhance dehalogenation of chlorinated hydrocarbons.
Archives of biochemistry and biophysics 1997;346(2):269-76.
1996: R Nakano; H Sato; A Watanabe; O Ito; T Shimizu
Conserved Glu318 at the cytochrome P450 1A2 distal site is crucial in the nitric oxide complex stability.
The Journal of biological chemistry 1996;271(15):8570-4.
1996: R Nakano; H Sato; T Shimizu
Tris(2,2'-bipyridyl)ruthenium(II)-mediated photoinduced electron transfer of engineered cytochrome P450 1A2.
Journal of photochemistry and photobiology. B, Biology 1996;32(3):171-6.
1995: R Nakano; H Konami; H Sato; O Ito; T Shimizu
Marked detergents effects on safranine T-mediated photo-induced electron transfer in cytochrome P-450 1A2.
Biochimica et biophysica acta 1995;1252(2):245-50.
1995: H Sato; T Shimizu
Marked effects of alcohols and imidazoles on the cumyl hydroperoxide reaction with the wild-type cytochrome P450 1A2.
Archives of biochemistry and biophysics 1995;322(1):277-83.
1994: T Shimizu; Y Murakami; M Hatano
Glu318 and Thr319 mutations of cytochrome P450 1A2 remarkably enhance homolytic O-O cleavage of alkyl hydroperoxides. An optical absorption spectral study.
The Journal of biological chemistry 1994;269(18):13296-304.
1994: H Mayuzumi; T Shimizu; C Sambongi; K Hiroya; M Hatano
Essential role of His163 of cytochrome P450 1A2 in catalytic functions associated with cytochrome b5.
Archives of biochemistry and biophysics 1994;310(2):367-72.
1994: K Hiroya; Y Murakami; T Shimizu; M Hatano; Paul R. Ortiz de Montellano
Differential roles of Glu318 and Thr319 in cytochrome P450 1A2 catalysis supported by NADPH-cytochrome P450 reductase and tert-butyl hydroperoxide.
Archives of biochemistry and biophysics 1994;310(2):397-401.
1993: H Mayuzumi; C Sambongi; K Hiroya; T Shimizu; T Tateishi; M Hatano
Effect of mutations of ionic amino acids of cytochrome P450 1A2 on catalytic activities toward 7-ethoxycoumarin and methanol.
Biochemistry 1993;32(21):5622-8.
1993: A G Krainev; T Shimizu; M Ishigooka; K Hiroya; M Hatano
Chiral recognition at cytochrome P450 1A2 active site: effects of mutations at the putative distal site on the bindings of asymmetrical axial ligands.
Biochemistry 1993;32(8):1951-7.
1992: A G Krainev; T Shimizu; K Hiroya; M Hatano
Effect of mutations at Lys250, Arg251, and Lys253 of cytochrome P450 1A2 on the catalytic activities and the bindings of bifunctional axial ligands.
Archives of biochemistry and biophysics 1992;298(1):198-203.
1992: M Ishigooka; T Shimizu; K Hiroya; M Hatano
Role of Glu318 at the putative distal site in the catalytic function of cytochrome P450d.
Biochemistry 1992;31(5):1528-31.
1992: K Hiroya; M Ishigooka; T Shimizu; M Hatano
Role of Glu318 and Thr319 in the catalytic function of cytochrome P450d (P4501A2): effects of mutations on the methanol hydroxylation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(2):749-51.
1991: A G Krainev; T Shimizu; M Ishigooka; K Hiroya; M Hatano; Y Fujii-Kuriyama
Absorption spectral study of cytochrome P450d-phenyl isocyanide complexes: effects of mutations at the putative distal site on the conformational stability.
Biochemistry 1991;30(47):11206-11.