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Shun Shimohama

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Syuuichirou Suzuki; Kazuyuki Takata; Shin Hisahara; Jun Kawamata; William Kem; Yoshihisa Kitamura; Akihiro Matsumura; Takashi Matsushita; Shun Shimohama
3-[(2,4-Dimethoxy)benzylidene]-anabaseine dihydrochloride protects against 6-hydroxydopamine-induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats.
Akihiro Matsumura; Masaki Saito; Shin Hisahara; Tomihiro Imai; Shun Shimohama
[Treatment outcome of patients with cranial base lesions of unknown etiology: focusing on infectious cases with multiple cranial nerve disorders].
Masatoshi Inden; Yoshihisa Kitamura; Kaneyasu Nishimura; Hiroyoshi Ariga; Eishi Ashihara; Osamu Honmou; Kazuyuki Takata; Kanji Yoshimoto; Shun Shimohama
Therapeutic effects of human mesenchymal and hematopoietic stem cells on rotenone-treated parkinsonian mice.

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2013: Syuuichirou Suzuki; Kazuyuki Takata; Shin Hisahara; Jun Kawamata; William Kem; Yoshihisa Kitamura; Akihiro Matsumura; Takashi Matsushita; Shun Shimohama
3-[(2,4-Dimethoxy)benzylidene]-anabaseine dihydrochloride protects against 6-hydroxydopamine-induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats.
Journal of neuroscience research 2013;91(3):462-71.
2013: Akihiro Matsumura; Masaki Saito; Shin Hisahara; Tomihiro Imai; Shun Shimohama
[Treatment outcome of patients with cranial base lesions of unknown etiology: focusing on infectious cases with multiple cranial nerve disorders].
Rinshō shinkeigaku = Clinical neurology 2013;53(1):9-18.
2013: Masatoshi Inden; Yoshihisa Kitamura; Kaneyasu Nishimura; Hiroyoshi Ariga; Eishi Ashihara; Osamu Honmou; Kazuyuki Takata; Kanji Yoshimoto; Shun Shimohama
Therapeutic effects of human mesenchymal and hematopoietic stem cells on rotenone-treated parkinsonian mice.
Journal of neuroscience research 2013;91(1):62-72.
2012: Haruki Koike; Shigeru Koyano; Shigehisa Mitake; Takayuki Momoo; Yoshiharu Nakae; Shun Shimohama; Rina Hashimoto; Mana Higashihara; Shin Hisahara; Masahiro Iijima; Ken Johkura; Kenichi Kaida; Yuichi Kawagashira; Minoru Tomita; Steven Vernino; Daisuke Yamamoto; Hiroyuki Yuasa; Gen Sobue
The spectrum of clinicopathological features in pure autonomic neuropathy.
Journal of neurology 2012;259(10):2067-75.
2012: Tomihiro Imai; Jun Kawamata; Masakatsu Motomura; Masaki Saitoh; Shin Hisahara; Takayoshi Hozuki; Emiko Tsuda; Rika Yamauchi; Hiroaki Yoshikawa; Shun Shimohama
Early effect of tacrolimus in improving excitation-contraction coupling in myasthenia gravis.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2012;123(9):1886-90.
2012: Shun Shimohama
[Anti-dementia drugs].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 6():291-6.
2012: Masato Maesako; Kazuki Sasaki; Shun Shimohama; Ryosuke Takahashi; Kengo Uemura; Maiko Uemura; Kiwamu Watanabe; Megumi Asada-Utsugi; Naoko Hayashida; Takeshi Kihara; Masakazu Kubota; Akira Kuzuya; Ayae Kinoshita
Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice.
The Journal of biological chemistry 2012;287(27):23024-33.
2012: Masato Maesako; Kazuki Sasaki; Shun Shimohama; Ryosuke Takahashi; Kengo Uemura; Kiwamu Watanabe; Haruhiko Akiyama; Koichi Ando; Megumi Asada; Takeshi Kihara; Masakazu Kubota; Akira Kuzuya; Ayae Kinoshita
Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling.
Journal of neurochemistry 2012;121(6):964-73.
2012: Tomihiro Imai; Jun Kawamata; Masakatsu Motomura; Masaki Saitoh; Shin Hisahara; Takayoshi Hozuki; Emiko Tsuda; Rika Yamauchi; Hiroaki Yoshikawa; Shun Shimohama
Contribution of anti-ryanodine receptor antibody to impairment of excitation-contraction coupling in myasthenia gravis.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2012;123(6):1242-7.
2012: Jun Kawamata; Syuuichirou Suzuki; Shun Shimohama
α7 nicotinic acetylcholine receptor mediated neuroprotection in Parkinson's disease.
Current drug targets 2012;13(5):623-30.
2012: Masato Maesako; Kazuki Sasaki; Shun Shimohama; Kengo Uemura; Kiwamu Watanabe; Megumi Asada; Naoko Hayashida; Masafumi Ihara; Hidefumi Ito; Takeshi Kihara; Masakazu Kubota; Akira Kuzuya; Ayae Kinoshita
Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice.
Neurobiology of aging 2012;33(5):1011.e11-23.
2012: Kazuyuki Takata; Manami Tawa; Hidekazu Tomimoto; Tetsuya Takada; Mayo Asai; Eishi Ashihara; Aina Ito; Yoshihisa Kitamura; Yuki Saito; Shun Shimohama
Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease.
International journal of Alzheimer's disease 2012;2012():685739.
2011: Shun Shimohama
[Galantamine].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 10(Pt 2):31-5.
2011: Takashi Matsushita; Shun Shimohama
[Nucleus basalis of Meynert and cholinergic neurotransmission].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 8():210-3.
2011: Megumi Asada-Utsugi; Oksana Berezovska; Takeshi Kihara; Koichi Ando; Masakazu Kubota; Akira Kuzuya; Masato Maesako; Yasuha Noda; Shun Shimohama; Makio Takahashi; Ryosuke Takahashi; Kengo Uemura; Kiwamu Watanabe; Ayae Kinoshita
N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production.
Journal of neurochemistry 2011;119(2):354-63.
2011: Takashi Matsushita; Masabumi Minami; Syuuichirou Suzuki; Yuuki Yamashita; Osamu Honmou; Takahiro Katayama; Jun Kawamata; Tatsuya Kibayashi; Shun Shimohama
Mesenchymal stem cells transmigrate across brain microvascular endothelial cell monolayers through transiently formed inter-endothelial gaps.
Neuroscience letters 2011;502(1):41-5.
2011: Shun Shimohama
[Dementia: progress in diagnosis and treatment; Topics, I. Basic knowledge of dementia and pathophysiology; 1. The concept and pathophysiology of dementia of Alzheimer-type].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2011;100(8):2092-8.
2011: Meng Han; Takashi Hayashi; Shin Hisahara; Takayoshi Hozuki; Tomihiro Imai; Michio Nonaka; Hirofumi Ohnishi; Masaki Saitoh; Shun Shimohama; Rika Yamauchi; Mitsuru Mori
Relationship between dysphagia and depressive states in patients with Parkinson's disease.
Parkinsonism & related disorders 2011;17(6):437-9.
2011: Jun Kawamata; Syuuichirou Suzuki; Shun Shimohama
Enhancement of nicotinic receptors alleviates cytotoxicity in neurological disease models.
Therapeutic advances in chronic disease 2011;2(3):197-208.
2011: Koichi Ando; Kengo Uemura; Akira Kuzuya; Masato Maesako; Megumi Asada-Utsugi; Masakazu Kubota; Nobuhisa Aoyagi; Katsuji Yoshioka; Katsuya Okawa; Haruhisa Inoue; Jun Kawamata; Shun Shimohama; Tetsuaki Arai; Ryosuke Takahashi; Ayae Kinoshita
N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease.
The Journal of biological chemistry 2011;286(9):7619-28.
2011: Tomihiro Imai; Emiko Tsuda; Takanobu Toyoshima; Hiroaki Yoshikawa; Masakatsu Motomura; Shun Shimohama
Anti-ryanodine receptor-positive acetylcholine receptor-negative myasthenia gravis: evidence of impaired excitation-contraction coupling.
Muscle & nerve 2011;43(2):294-5.
2011: Yoko Okamoto; Miki Oono; Shun Shimohama; Yoshitomo Shirakashi; Asao Hirano; Masafumi Ihara; Hidefumi Ito; Shinsuke Kato; Yasuhiro Kawamoto; Hidekazu Tomimoto; Makoto Urushitani; Hirofumi Yamashita; Ryosuke Takahashi
Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model.
PloS one 2011;6(5):e20427.
2011: Jun Kawamata; Shun Shimohama
Stimulating nicotinic receptors trigger multiple pathways attenuating cytotoxicity in models of Alzheimer's and Parkinson's diseases.
Journal of Alzheimer's disease : JAD 2011;24 Suppl 2():95-109.
2010: Kazuyuki Takata; Yoshihisa Kitamura; Mana Saeki; Maki Terada; Sachiko Kagitani; Risa Kitamura; Yasuhiro Fujikawa; Alfred Maelicke; Hidekazu Tomimoto; Takashi Taniguchi; Shun Shimohama
Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors.
The Journal of biological chemistry 2010;285(51):40180-91.
2010: H Shen; Takeshi Kihara; H Hongo; X Wu; W R Kem; Shun Shimohama; Akinori Akaike; Takuro Niidome; Hachiro Sugimoto
Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors.
British journal of pharmacology 2010;161(1):127-39.
2010: Emiko Tsuda; Tomihiro Imai; Takayoshi Hozuki; Rika Yamauchi; Masaki Saitoh; Shin Hisahara; Hiroaki Yoshikawa; Masakatsu Motomura; Shun Shimohama
Correlation of bite force with excitation-contraction coupling time of the masseter in myasthenia gravis.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2010;121(7):1051-8.
2010: Akihiko Nunomura; Toshio Tamaoki; Koich Tanaka; Nobutaka Motohashi; Masao Nakamura; Takaaki Hayashi; Haruyasu Yamaguchi; Shun Shimohama; Hyoung-gon Lee; Xiongwei Zhu; Mark A. Smith; George Perry
Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease.
Neurobiology of disease 2010;37(3):731-7.
2010: Nobuhisa Aoyagi; Kengo Uemura; Akira Kuzuya; Takeshi Kihara; Jun Kawamata; Shun Shimohama; Ayae Kinoshita; Ryosuke Takahashi
PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity.
Biochemical and biophysical research communications 2010;391(2):1240-5.
2010: Shin Hisahara; Shun Shimohama
Toxin-induced and genetic animal models of Parkinson's disease.
Parkinson's disease 2010;2011():951709.
2010: Takayoshi Hozuki; Tomihiro Imai; Emiko Tsuda; Akihiro Matsumura; Daisuke Yamamoto; Takanobu Toyoshima; Syuuichiro Suzuki; Rika Yamauchi; Takashi Hayashi; Shin Hisahara; Shun Shimohama
Response of serum carboxylated and undercarboxylated osteocalcin to risedronate monotherapy and combined therapy with vitamin K(2) in corticosteroid-treated patients: a pilot study.
Internal medicine (Tokyo, Japan) 2010;49(5):371-6.
2010: Kentaro Yamakawa; Yasuhiko Izumi; Hiroki Takeuchi; Noriyuki Yamamoto; Toshiaki Kume; Akinori Akaike; Ryosuke Takahashi; Shun Shimohama; Hideyuki Sawada
Dopamine facilitates alpha-synuclein oligomerization in human neuroblastoma SH-SY5Y cells.
Biochemical and biophysical research communications 2010;391(1):129-34.
2009: Kazuyuki Takata; Yoshihisa Kitamura; Yukinori Nakata; Yasuji Matsuoka; Hidekazu Tomimoto; Takashi Taniguchi; Shun Shimohama
Involvement of WAVE accumulation in Abeta/APP pathology-dependent tangle modification in Alzheimer's disease.
The American journal of pathology 2009;175(1):17-24.
2009: Shun Shimohama
Nicotinic receptor-mediated neuroprotection in neurodegenerative disease models.
Biological & pharmaceutical bulletin 2009;32(3):332-6.
2009: Hiroki Takeuchi; Takashi Yanagida; Masatoshi Inden; Kazuyuki Takata; Yoshihisa Kitamura; Kentaro Yamakawa; Hideyuki Sawada; Yasuhiko Izumi; Noriyuki Yamamoto; Takeshi Kihara; Kengo Uemura; Haruhisa Inoue; Takashi Taniguchi; Akinori Akaike; Ryosuke Takahashi; Shun Shimohama
Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models.
Journal of neuroscience research 2009;87(2):576-85.
2009: Emiko Tsuda; Tomihiro Imai; Takayoshi Hozuki; Daisuke Yamamoto; Kuniaki Harada; Shun Shimohama
Transient oculomotor palsy correlated with nerve enhancement on MRI in chronic inflammatory demyelinating polyneuropathy.
Internal medicine (Tokyo, Japan) 2009;48(22):1985-7.
2008: Takashi Yanagida; Hiroki Takeuchi; Yoshihisa Kitamura; Kazuyuki Takata; Hideaki Minamino; Tomonori Shibaike; Jun Tsushima; Koji Kishimoto; Hiroyuki Yasui; Takashi Taniguchi; Shun Shimohama
Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model.
Neuroscience research 2008;62(4):254-61.
2008: A Matsumura; M Oda; T Hozuki; Tomihiro Imai; Shun Shimohama
Dural arteriovenous fistula in a case of dementia with bithalamic MR lesions.
Neurology 2008;71(19):1553.
2008: Shin Hisahara; Susumu Chiba; Hiroyuki Matsumoto; Masaya Tanno; Hideshi Yagi; Shun Shimohama; Makoto Sato; Yoshiyuki Horio
Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15599-604.
2008: Shun Shimohama
[Treatment of Alzheimer's disease: status quo and future considerations].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2008;131(5):351-6.
2008: Emiko Tsuda; Tomihiro Imai; Akihiro Matsumura; Shin Hisahara; Michio Nonaka; Hirokazu Shiraishi; Masakatsu Motomura; Shun Shimohama
Thyrotoxic myopathy mimicking myasthenic syndrome associated with thymic hyperplasia.
Internal medicine (Tokyo, Japan) 2008;47(5):445-7.
2007: Shun Shimohama
[Parkinsonism].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2007;44(5):564-7.
2007: Hirofumi Yamashita; Jun Kawamata; Katsuya Okawa; Rie Kanki; Tomoki Nakamizo; Takumi Hatayama; Koji Yamanaka; Ryosuke Takahashi; Shun Shimohama
Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase: clues to a possible strategy for treating ALS.
Journal of neurochemistry 2007;102(5):1497-505.
2007: Kaneyasu Nishimura; Yoshihisa Kitamura; Takeshi Inoue; Yoshihiko Umesono; Shozo Sano; Kanji Yoshimoto; Masatoshi Inden; Kazuyuki Takata; Takashi Taniguchi; Shun Shimohama; Kiyokazu Agata
Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates.
Developmental neurobiology 2007;67(8):1059-78.
2007: Masatoshi Inden; Yoshihisa Kitamura; Hiroki Takeuchi; Takashi Yanagida; Kazuyuki Takata; Yuka Kobayashi; Takashi Taniguchi; Kanji Yoshimoto; Masahiko Kaneko; Yasunobu Okuma; Takahiro Taira; Hiroyoshi Ariga; Shun Shimohama
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.
Journal of neurochemistry 2007;101(6):1491-1504.
2007: Kengo Uemura; Akira Kuzuya; Yoshiharu Shimozono; Nobuhisa Aoyagi; Koichi Ando; Shun Shimohama; Ayae Kinoshita
GSK3beta activity modifies the localization and function of presenilin 1.
The Journal of biological chemistry 2007;282(21):15823-32.
2007: Kengo Uemura; Akira Kuzuya; Nobuhisa Aoyagi; Koichi Ando; Y Shimozono; Haruaki Ninomiya; Shun Shimohama; Ayae Kinoshita
Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor.
Neuroscience 2007;145(1):5-10.
2007: Yasuhiko Izumi; Hideyuki Sawada; Noriyuki Yamamoto; Toshiaki Kume; Hiroshi Katsuki; Shun Shimohama; Akinori Akaike
Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity.
European journal of pharmacology 2007;557(2-3):132-40.
2007: Noriyuki Yamamoto; Hideyuki Sawada; Yasuhiko Izumi; Toshiaki Kume; Hiroshi Katsuki; Shun Shimohama; Akinori Akaike
Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease.
The Journal of biological chemistry 2007;282(7):4364-72.
2007: Kazuyuki Takata; Yoshihisa Kitamura; Daijiro Yanagisawa; Shigehiro Morikawa; Masahito Morita; Toshiro Inubushi; Daiju Tsuchiya; Saori Chishiro; Mana Saeki; Takashi Taniguchi; Shun Shimohama; Ikuo Tooyama
Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats.
FEBS letters 2007;581(3):475-8.
2007: Akira Kuzuya; Kengo Uemura; Naoyuki Kitagawa; Nobuhisa Aoyagi; Takeshi Kihara; Haruaki Ninomiya; Shoichi Ishiura; Ryosuke Takahashi; Shun Shimohama
Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
Journal of neuroscience research 2007;85(1):153-65.
2006: Daiju Tsuchiya; Yoshihisa Kitamura; Kazuyuki Takata; Tatsuhiko Sugisaki; Takashi Taniguchi; Kengo Uemura; Hiroaki Miki; Tadaomi Takenawa; Shun Shimohama
Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus.
Neuroscience research 2006;56(4):459-69.
2006: Hideyuki Sawada; Kentarou Yamakawa; Shun Shimohama; Ryosuke Takahashi; Akinori Akaike; Yoshihisa Kitamura; Takashi Taniguchi
[Lewy bodies: neuroprotective?].
Rinshō shinkeigaku = Clinical neurology 2006;46(11):893.
2006: Takeshi Kihara; Shun Shimohama
Occipital neuralgia evoked by facial herpes zoster infection.
Headache 2006;46(10):1590-1.
2006: Daiju Tsuchiya; Yoshihisa Kitamura; Kazuyuki Takata; Takashi Taniguchi; Kengo Uemura; Hiroaki Miki; Tadaomi Takenawa; Shun Shimohama
Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells.
Journal of pharmacological sciences 2006;102(3):354-8.
2006: Daijiro Yanagisawa; Meirigeng Qi; Do-hoon Kim; Yoshihisa Kitamura; Masatoshi Inden; Daiju Tsuchiya; Kazuyuki Takata; Takashi Taniguchi; Kanji Yoshimoto; Shun Shimohama; Akinori Akaike; Shoichiro Sumi; Kazutomo Inoue
Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells.
Neuroscience letters 2006;407(1):74-9.
2006: Masatoshi Inden; Takahiro Taira; Yoshihisa Kitamura; Takashi Yanagida; Daiju Tsuchiya; Kazuyuki Takata; Daijiro Yanagisawa; Kaneyasu Nishimura; Takashi Taniguchi; Yoshiaki Kiso; Kanji Yoshimoto; Tomohiro Agatsuma; Shizuyo Koide-Yoshida; Sanae M M Iguchi-Ariga; Shun Shimohama; Hiroyoshi Ariga
PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model.
Neurobiology of disease 2006;24(1):144-58.
2006: Takahiro Mitsueda-Ono; Akio Ikeda; Eri Noguchi; Shigetoshi Takaya; Hidenao Fukuyama; Shun Shimohama; Ryosuke Takahashi
Epileptic polyopia with right temporal lobe epilepsy as studied by FDG-PET and MRI: a case report.
Journal of the neurological sciences 2006;247(1):109-11.
2006: Kengo Uemura; Takeshi Kihara; Akira Kuzuya; Katsuya Okawa; Takaaki Nishimoto; Haruaki Ninomiya; Hachiro Sugimoto; Ayae Kinoshita; Shun Shimohama
Characterization of sequential N-cadherin cleavage by ADAM10 and PS1.
Neuroscience letters 2006;402(3):278-83.
2006: Kengo Uemura; Takeshi Kihara; Akira Kuzuya; Katsuya Okawa; Takaaki Nishimoto; Haruhiko Bito; Haruaki Ninomiya; Hachiro Sugimoto; Ayae Kinoshita; Shun Shimohama
Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin.
Biochemical and biophysical research communications 2006;345(3):951-8.
2006: Hiroki Takeuchi; Akio Ikeda; Yoshinobu Otsuka; Eiji Saiki; Shun Shimohama; Ryosuke Takahashi
[A case with temporal lobe epilepsy associated with hypocalcemia due to primary hypoparathyroidism].
Rinshō shinkeigaku = Clinical neurology 2006;46(7):510-2.
2006: Kazuki Nagasawa; Junya Akagi; Mineto Koma; Taichi Kakuda; Katsuhito Nagai; Shun Shimohama; Sadaki Fujimoto
Transport and toxic mechanism for aluminum citrate in human neuroblastoma SH-SY5Y cells.
Life sciences 2006;79(1):89-97.
2006: Yasuko Nakagawa; Riki Matsumoto; Akio Ikeda; Nobuhiro Mikuni; Masao Matsuhashi; Takashi Hanakawa; Hidenao Fukuyama; Shun Shimohama
[Focal cortical dysplasia at the primary somatosensory cortex could manifest both intractable partial epilepsy and cortical reflex myoclonus].
Rinshō shinkeigaku = Clinical neurology 2006;46(5):335-8.
2006: Akio Ikeda; Masaru Matsui; Yoshiki Hase; Takehumi Hitomi; Yukitoshi Takahashi; Hiroshi Shibasaki; Shun Shimohama
"Burst and slow complexes" in nonconvulsive epileptic status.
Epileptic disorders : international epilepsy journal with videotape 2006;8(1):61-4.
2006: Hiroyasu Akatsu; Hidehisa Yamagata; Jun Kawamata; Kouzin Kamino; Masatoshi Takeda; Takayuki Yamamoto; Tetsuro Miki; Ikuo Tooyama; Shun Shimohama; Kenji Kosaka
Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan.
Dementia and geriatric cognitive disorders 2006;22(3):216-22.
2006: Tahamina Begum; Akio Ikeda; Jun Takahashi; Hidekazu Tomimoto; Shun Shimohama; Satow Takeshi; Takashi Nagamine; Hidenao Fukuyama; Hiroshi Shibasaki
Clinical outcome of patients with SREDA (subclinical rhythmic EEG discharge of adults).
Internal medicine (Tokyo, Japan) 2006;45(3):141-4.
2006: Masafumi Ihara; Fumi Makino; Hideyuki Sawada; Takahiro Mezaki; Kotaro Mizutani; Hiroshi Nakase; Makoto Matsui; Hidekazu Tomimoto; Shun Shimohama
Gluten sensitivity in Japanese patients with adult-onset cerebellar ataxia.
Internal medicine (Tokyo, Japan) 2006;45(3):135-40.
2005: Riki Matsumoto; Akio Ikeda; Takefumi Hitomi; T Aoki; Takashi Hanakawa; Yukio Miki; Hidekazu Tomimoto; Shun Shimohama; Hiroshi Shibasaki
Ictal monoparesis associated with lesions in the primary somatosensory area.
Neurology 2005;65(9):1476-8.
2005: Masatoshi Inden; Yoshihisa Kitamura; Jun-Ichi Kondo; Kousuke Hayashi; Takashi Yanagida; Kazuyuki Takata; Daiju Tsuchiya; Daijiro Yanagisawa; Kaneyasu Nishimura; Takashi Taniguchi; Shun Shimohama; Hachiro Sugimoto; Akinori Akaike
Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats.
Journal of neurochemistry 2005;95(4):950-61.
2005: Masatoshi Inden; Do-hoon Kim; Meirigeng Qi; Yoshihisa Kitamura; Daijiro Yanagisawa; Kaneyasu Nishimura; Daiju Tsuchiya; Kazuyuki Takata; Kousuke Hayashi; Takashi Taniguchi; Kanji Yoshimoto; Shun Shimohama; Shoichiro Sumi; Kazutomo Inoue
Transplantation of mouse embryonic stem cell-derived neurons into the striatum, subthalamic nucleus and substantia nigra, and behavioral recovery in hemiparkinsonian rats.
Neuroscience letters 2005;387(3):151-6.
2005: Takefumi Hitomi; Takahiro Mezaki; Hidekazu Tomimoto; Akio Ikeda; Shun Shimohama; Toshirou Okazaki; Taku Uchiyama; Hiroshi Shibasaki
Long-term effect of bone marrow transplantation in adult-onset adrenoleukodystrophy.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2005;12(10):807-10.
2005: Yasuhiko Izumi; Hideyuki Sawada; Noriyuki Yamamoto; Toshiaki Kume; Hiroshi Katsuki; Shun Shimohama; Akinori Akaike
Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells.
Journal of neuroscience research 2005;82(1):126-37.
2005: Kenji Yamamoto; Yu Sakagami; Shigeki Sugiura; Kaoru Inokuchi; Shun Shimohama; Nobuo Kato
Homer 1a enhances spike-induced calcium influx via L-type calcium channels in neocortex pyramidal cells.
The European journal of neuroscience 2005;22(6):1338-48.
2005: Toshiaki Kume; Yuko Kawai; Kohei Yoshida; Tomoki Nakamizo; Rie Kanki; Hideyuki Sawada; Hiroshi Katsuki; Shun Shimohama; Hachiro Sugimoto; Akinori Akaike
Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons.
Neuroscience letters 2005;383(3):199-202.
2005: Kayoko Nakaji; Akio Ikeda; Yasunori Oka; Hidekazu Tomimoto; Shun Shimohama; Takashi Kanbayashi; Hiroshi Shibasaki
Hypersomnia caused by isolated angiitis of the CNS.
Internal medicine (Tokyo, Japan) 2005;44(8):883-5.
2005: Kazuhiro Honda; Mark A. Smith; Xiongwei Zhu; Diane Baus; William C Merrick; Alan M Tartakoff; Thomas Hattier; Peggy L R Harris; Sandra L Siedlak; Hisashi Fujioka; Quan Liu; Paula I Moreira; Frank P Miller; Akihiko Nunomura; Shun Shimohama; George Perry
Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron.
The Journal of biological chemistry 2005;280(22):20978-86.
2005: Tomoki Nakamizo; Jun Kawamata; Hirofumi Yamashita; Rie Kanki; Takeshi Kihara; Hideyuki Sawada; Akinori Akaike; Shun Shimohama
Stimulation of nicotinic acetylcholine receptors protects motor neurons.
Biochemical and biophysical research communications 2005;330(4):1285-9.
2005: Quan Liu; Mark A. Smith; Jesús Avila; John DeBernardis; Mayank M Kansal; Atsushi Takeda; Xiongwei Zhu; Akihiko Nunomura; Kazuhiro Honda; Paula I Moreira; Catarina R Oliveira; Maria S Santos; Shun Shimohama; Gjumrakch Aliev; Jack C. de la Torre; Hossein A Ghanbari; Sandra L Siedlak; Peggy L R Harris; Lawrence M Sayre; George Perry
Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations.
Free radical biology & medicine 2005;38(6):746-54.
2005: Yasuhiko Izumi; Hideyuki Sawada; Noriko Sakka; Noriyuki Yamamoto; Toshiaki Kume; Hiroshi Katsuki; Shun Shimohama; Akinori Akaike
p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly.
Journal of neuroscience research 2005;79(6):849-60.
2005: Hideyuki Sawada; Kentarou Yamakawa; Hodaka Yamakado; Ryohei Hosokawa; Muneo Ohba; Kazuaki Miyamoto; Takashi Kawamura; Shun Shimohama
Cocaine and phenylephrine eye drop test for Parkinson disease.
JAMA : the journal of the American Medical Association 2005;293(8):932-4.
2005: Masatoshi Inden; Jun-Ichi Kondo; Yoshihisa Kitamura; Kazuyuki Takata; Kaneyasu Nishimura; Takashi Taniguchi; Hideyuki Sawada; Shun Shimohama
Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats.
Journal of pharmacological sciences 2005;97(2):203-11.
2005: Yoshihisa Kitamura; Daijiro Yanagisawa; Masatoshi Inden; Kazuyuki Takata; Daiju Tsuchiya; Toshiyuki Kawasaki; Takashi Taniguchi; Shun Shimohama
Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia.
Journal of pharmacological sciences 2005;97(2):289-93.
2004: Takeshi Kihara; Hideyuki Sawada; Tomoki Nakamizo; Rie Kanki; Hirofumi Yamashita; Alfred Maelicke; Shun Shimohama
Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity.
Biochemical and biophysical research communications 2004;325(3):976-82.
2004: Kazuyuki Takata; Yoshihisa Kitamura; Daiju Tsuchiya; Toshiyuki Kawasaki; Takashi Taniguchi; Shun Shimohama
High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity.
Journal of neuroscience research 2004;78(6):880-91.
2004: Hiroshi Shibasaki; Takefumi Hitomi; Takahiro Mezaki; Takeshi Kihara; Hidekazu Tomimoto; Akio Ikeda; Shun Shimohama; Masatoshi Ito; Nobuyuki Oka
A new form of congenital proprioceptive sensory neuropathy associated with arthrogryposis multiplex.
Journal of neurology 2004;251(11):1340-4.
2004: Kazuki Nagasawa; Kentaro Nishida; Katsuhito Nagai; Shun Shimohama; Sadaki Fujimoto
Differential expression profiles of PLC-beta1 and -delta1 in primary cultured rat cortical neurons treated with N-methyl-D-aspartate and peroxynitrite.
Neuroscience letters 2004;367(2):246-9.
2004: Masatoshi Inden; Dohoon Kim; Yuanjin Gu; Yoshihisa Kitamura; Jun-Ichi Kondo; Daiju Tsuchiya; Takashi Taniguchi; Shun Shimohama; Akinori Akaike; Shoichiro Sumi; Kazutomo Inoue
Pharmacological characteristics of rotational behavior in hemiparkinsonian rats transplanted with mouse embryonic stem cell-derived neurons.
Journal of pharmacological sciences 2004;96(1):53-64.
2004: Rie Kanki; Tomoki Nakamizo; Hirofumi Yamashita; Takeshi Kihara; Hideyuki Sawada; Kengo Uemura; Jun Kawamata; Hiroshi Shibasaki; Akinori Akaike; Shun Shimohama
Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons.
Brain research 2004;1015(1-2):73-81.
2004: Kazuki Nagasawa; Hiromitsu Aoki; Eri Yasuda; Katsuhito Nagai; Shun Shimohama; Sadaki Fujimoto
Possible involvement of group I mGluRs in neuroprotective effect of theanine.
Biochemical and biophysical research communications 2004;320(1):116-22.
2004: Aiko Shiozaki; Teruyuki Tsuji; Ryuichi Kohno; Jun Kawamata; Kengo Uemura; Hiroshi Teraoka; Shun Shimohama
Proteome analysis of brain proteins in Alzheimer's disease: subproteomics following sequentially extracted protein preparation.
Journal of Alzheimer's disease : JAD 2004;6(3):257-68.
2004: Xiongwei Zhu; Yang Wang; Osamu Ogawa; Hyoung-gon Lee; Arun K Raina; Sandra L Siedlak; Peggy L R Harris; Hisashi Fujioka; Shun Shimohama; Massimo Tabaton; Craig S Atwood; Robert B Petersen; George Perry; Mark A. Smith
Neuroprotective properties of Bcl-w in Alzheimer disease.
Journal of neurochemistry 2004;89(5):1233-40.
2004: Ryuichi Kohno; Hideyuki Sawada; Yasuhiro Kawamoto; Kengo Uemura; Hiroshi Shibasaki; Shun Shimohama
BDNF is induced by wild-type alpha-synuclein but not by the two mutants, A30P or A53T, in glioma cell line.
Biochemical and biophysical research communications 2004;318(1):113-8.
2004: Hideyuki Sawada; Ryuichi Kohno; Takeshi Kihara; Yasuhiko Izumi; Noriko Sakka; Masakazu Ibi; Miki Nakanishi; Tomoki Nakamizo; Kentarou Yamakawa; Hiroshi Shibasaki; Noriyuki Yamamoto; Akinori Akaike; Masatoshi Inden; Yoshihisa Kitamura; Takashi Taniguchi; Shun Shimohama
Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions.
The Journal of biological chemistry 2004;279(11):10710-9.
2004: Kengo Uemura; Akira Kuzuya; Shun Shimohama
Protein trafficking and Alzheimer's disease.
Current Alzheimer research 2004;1(1):1-10.
2004: Takeshi Kihara; Shun Shimohama
Alzheimer's disease and acetylcholine receptors.
Acta neurobiologiae experimentalis 2004;64(1):99-105.
2003: Noriko Sakka; Hideyuki Sawada; Yasuhiko Izumi; Toshiaki Kume; Hiroshi Katsuki; Shuji Kaneko; Shun Shimohama; Akinori Akaike
Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone.
Neuroreport 2003;14(18):2425-8.
2003: Kengo Uemura; Naoyuki Kitagawa; Ryuichi Kohno; Akira Kuzuya; Takashi Kageyama; Kazuhisa Chonabayashi; Hiroshi Shibasaki; Shun Shimohama
Presenilin 1 is involved in maturation and trafficking of N-cadherin to the plasma membrane.
Journal of neuroscience research 2003;74(2):184-91.
2003: Yoshihisa Kitamura; Daiju Tsuchiya; Kazuyuki Takata; Keiichi Shibagaki; Takashi Taniguchi; Mark A. Smith; George Perry; Hiroaki Miki; Tadaomi Takenawa; Shun Shimohama
Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease.
Neuroscience letters 2003;346(3):149-52.
2003: Shun Shimohama; Hideyuki Sawada; Yoshihisa Kitamura; Takashi Taniguchi
Disease model: Parkinson's disease.
Trends in molecular medicine 2003;9(8):360-5.
2003: Kazuki Nagasawa; Hiroko Tanino; Shun Shimohama; Sadaki Fujimoto
Effects of hyperoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heart and brain.
Life sciences 2003;73(11):1453-62.
2003: Kengo Uemura; Naoyuki Kitagawa; Ryuichi Kohno; Akira Kuzuya; Takashi Kageyama; Hiroshi Shibasaki; Shun Shimohama
Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling.
Journal of neuroscience research 2003;73(2):166-75.
2003: Yoshihisa Kitamura; Takashi Taniguchi; Shun Shimohama; Akinori Akaike; Yasuyuki Nomura
Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists.
Neurochemical research 2003;28(7):1035-40.
2003: Kazuyuki Takata; Yoshihisa Kitamura; Daiju Tsuchiya; Toshiyuki Kawasaki; Takashi Taniguchi; Shun Shimohama
Heat shock protein-90-induced microglial clearance of exogenous amyloid-beta1-42 in rat hippocampus in vivo.
Neuroscience letters 2003;344(2):87-90.
2003: Yoshihisa Kitamura; Masatoshi Inden; Hisakazu Sanada; Kazuyuki Takata; Takashi Taniguchi; Shun Shimohama; Hidefumi Orii; Makoto Mochii; Kiyokazu Agata; Kenji Watanabe
Inhibitory effects of antiparkinsonian drugs and caspase inhibitors in a parkinsonian flatworm model.
Journal of pharmacological sciences 2003;92(2):137-42.
2003: Yoshihisa Kitamura; Keiichi Shibagaki; Kazuyuki Takata; Daiju Tsuchiya; Takashi Taniguchi; Peter J Gebicke-Haerter; Hiroaki Miki; Tadaomi Takenawa; Shun Shimohama
Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia.
Journal of pharmacological sciences 2003;92(2):115-23.
2003: Hideyuki Sawada; Shun Shimohama
Estrogens and Parkinson disease: novel approach for neuroprotection.
Endocrine 2003;21(1):77-9.
2003: Naoyuki Kitagawa; Shun Shimohama; Tomoko Oeda; Kengo Uemura; Ryuichi Kohno; Akira Kuzuya; Hiroshi Shibasaki; Naoaki Ishii
The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities.
The Journal of biological chemistry 2003;278(14):12130-4.
2003: Kazuyuki Takata; Yoshihisa Kitamura; Masaaki Umeki; Daiju Tsuchiya; Jun-ichi Kakimura; Takashi Taniguchi; Peter J Gebicke-Haerter; Shun Shimohama
Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta 12,14 prostaglandin J2-sensitive microglial activation.
Journal of pharmacological sciences 2003;91(4):330-3.
2003: Arun K Raina; Ayala Hochman; Harold Ickes; Xiongwei Zhu; Osamu Ogawa; Adam D Cash; Shun Shimohama; George Perry; Mark A. Smith
Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out?
Progress in neuro-psychopharmacology & biological psychiatry 2003;27(2):251-4.
2003: Takefumi Hitomi; Takahiro Mezaki; T Tsujii; Masako Kinoshita; Hidekazu Tomimoto; Akio Ikeda; Shun Shimohama; Toshirou Okazaki; Taku Uchiyama; Hiroshi Shibasaki
Improvement of central motor conduction after bone marrow transplantation in adrenoleukodystrophy.
Journal of neurology, neurosurgery, and psychiatry 2003;74(3):373-5.
2003: Yoshihisa Kitamura; Yuji Ishida; Kazuyuki Takata; Hiroto Mizutani; Jun-ichi Kakimura; Masatoshi Inden; Junko Nakata; Takashi Taniguchi; Tetsuya Tsukahara; Akinori Akaike; Shun Shimohama
Hyperbilirubinemia protects against focal ischemia in rats.
Journal of neuroscience research 2003;71(4):544-50.
2003: Tomoki Nakamizo; Jun Kawamata; Kohei Yoshida; Yuko Kawai; Rie Kanki; Hideyuki Sawada; Takeshi Kihara; Hirofumi Yamashita; Hiroshi Shibasaki; Akinori Akaike; Shun Shimohama
Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons.
Journal of neuroscience research 2003;71(4):485-95.
2003: Kazuyuki Takata; Yoshihisa Kitamura; Jun-ichi Kakimura; Keiichi Shibagaki; Daiju Tsuchiya; Takashi Taniguchi; Mark A. Smith; George Perry; Shun Shimohama
Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis.
Biochemical and biophysical research communications 2003;301(3):699-703.
2003: Arun K Raina; Xiongwei Zhu; Shun Shimohama; George Perry; Mark A. Smith
Tipping the apoptotic balance in Alzheimer's disease: the abortosis concept.
Cell biochemistry and biophysics 2003;39(3):249-55.
2002: George Perry; Marta A Taddeo; Akihiko Nunomura; Xiongwei Zhu; Tania Zenteno-Savin; Kelly L Drew; Shun Shimohama; Jesús Avila; Rudy J Castellani; Mark A. Smith
Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2002;133(4):507-13.
2002: Yoshihisa Kitamura; Masatoshi Inden; Atsushi Miyamura; Jun-ichi Kakimura; Takashi Taniguchi; Shun Shimohama
Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells.
Neuroscience letters 2002;333(1):25-8.
2002: Kazuyuki Takata; Yoshihisa Kitamura; Jun-ichi Kakimura; Keiichi Shibagaki; Tadatsugu Taniguchi; Peter J Gebicke-Haerter; Mark A. Smith; George Perry; Shun Shimohama
Possible protective mechanisms of heme oxygenase-1 in the brain.
Annals of the New York Academy of Sciences 2002;977():501-6.
2002: Jun-ichi Kakimura; Yoshihisa Kitamura; Kazuyuki Takata; Daiju Tsuchiya; Tadatsugu Taniguchi; Peter J Gebicke-Haerter; Mark A. Smith; George Perry; Shun Shimohama
Possible involvement of ER chaperone Grp78 on reduced formation of amyloid-beta deposits.
Annals of the New York Academy of Sciences 2002;977():327-32.
2002: Takeshi Kihara; Shun Shimohama; Hideyuki Sawada; Kazuhiro Honda; Tomoki Nakamizo; Rie Kanki; Hiroshi Yamashita; Akinori Akaike
Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade.
Journal of neuroscience research 2002;70(3):274-82.
2002: Teruyuki Tsuji; A Shiozaki; Ryuichi Kohno; Katsutoshi Yoshizato; Shun Shimohama
Proteomic profiling and neurodegeneration in Alzheimer's disease.
Neurochemical research 2002;27(10):1245-53.
2002: Hideyuki Sawada; Masakazu Ibi; Takeshi Kihara; Kazuhiro Honda; Tomoki Nakamizo; Rie Kanki; Miki Nakanishi; Noriko Sakka; Akinori Akaike; Shun Shimohama
Estradiol protects dopaminergic neurons in a MPP+Parkinson's disease model.
Neuropharmacology 2002;42(8):1056-64.
2002: Jun Kawamata; Shun Shimohama
Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2002;4(2):71-6.
2002: Jun-ichi Kakimura; Yoshihisa Kitamura; Kazuyuki Takata; Masaaki Umeki; Sanae Suzuki; Keiichi Shibagaki; Takashi Taniguchi; Yasuyuki Nomura; Peter J Gebicke-Haerter; Mark A. Smith; George Perry; Shun Shimohama
Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(6):601-3.
2002: Toshiaki Kume; Naoki Asai; Hiroyuki Nishikawa; Nariyasu Mano; Taro Terauchi; Ryota Taguchi; Hisashi Shirakawa; Fumitaka Osakada; Hiroki Mori; Naoki Asakawa; Masahiro Yonaga; Yukio Nishizawa; Hachiro Sugimoto; Shun Shimohama; Hiroshi Katsuki; Shuji Kaneko; Akinori Akaike
Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3288-93.
2002: Takafumi Wataya; Akihiko Nunomura; Mark A. Smith; Sandra L Siedlak; Peggy L R Harris; Shun Shimohama; Luke I Szweda; Matthew A Kaminski; Jesús Avila; Donald L Price; Don W Cleveland; Lawrence M Sayre; George Perry
High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal.
The Journal of biological chemistry 2002;277(7):4644-8.
2002: Rudy J Castellani; George Perry; Sandra L Siedlak; Akihiko Nunomura; Shun Shimohama; Jing Zhang; Thomas J Montine; Lawrence M Sayre; Mark A. Smith
Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans.
Neuroscience letters 2002;319(1):25-8.
2002: George Perry; Akihiko Nunomura; Adam D Cash; Marta A Taddeo; Keisuke Hirai; Gjumrakch Aliev; Jesús Avila; Takafumi Wataya; Shun Shimohama; Craig S Atwood; Mark A. Smith
Reactive oxygen: its sources and significance in Alzheimer disease.
Journal of neural transmission. Supplementum 2002;(62):69-75.
2002: Kenji Yamamoto; M Nakano; K Hashimoto; Shun Shimohama; Nobuo Kato
Emergence of a functional coupling between inositol-1,4,5-trisphosphate receptors and calcium channels in developing neocortical neurons.
Neuroscience 2002;109(4):677-85.
2002: Kenji Yamamoto; K Hashimoto; M Nakano; Shun Shimohama; Nobuo Kato
A distinct form of calcium release down-regulates membrane excitability in neocortical pyramidal cells.
Neuroscience 2002;109(4):665-76.
2002: Teruyuki Tsuji; Shun Shimohama
Protein degradation in Alzheimer's disease and aging of the brain.
Progress in molecular and subcellular biology 2002;29():43-60.
2001: Shun Shimohama; Hiroko Tanino; Shimpei Fujimoto
Differential expression of rat brain caspase family proteins during development and aging.
Biochemical and biophysical research communications 2001;289(5):1063-6.
2001: Shun Shimohama; Hiroko Tanino; Shimpei Fujimoto
Differential subcellular localization of caspase family proteins in the adult rat brain.
Neuroscience letters 2001;315(3):125-8.
2001: Hiroko Tanino; T Kusuda; Kazuki Nagasawa; Shun Shimohama; Shimpei Fujimoto
Alterations of phospholipase C isozymes in rat cerebral cortex through hyperoxia.
Biological & pharmaceutical bulletin 2001;24(11):1241-5.
2001: Xiongwei Zhu; Catherine A Rottkamp; Anthony W Hartzler; Zheng Sun; Atsushi Takeda; H Boux; Shun Shimohama; George Perry; Mark A. Smith
Activation of MKK6, an upstream activator of p38, in Alzheimer's disease.
Journal of neurochemistry 2001;79(2):311-8.
2001: Tomoko Oeda; Shun Shimohama; Naoyuki Kitagawa; Ryuichi Kohno; T Imura; Hiroshi Shibasaki; N Ishii
Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans.
Human molecular genetics 2001;10(19):2013-23.
2001: Akihiko Nunomura; George Perry; Gjumrakch Aliev; Keisuke Hirai; Atsushi Takeda; Elizabeth Balraj; Paul K Jones; Hossein A Ghanbari; Takafumi Wataya; Shun Shimohama; S Chiba; Craig S Atwood; Robert B Petersen; Mark A. Smith
Oxidative damage is the earliest event in Alzheimer disease.
Journal of neuropathology and experimental neurology 2001;60(8):759-67.
2001: M Urushitani; Shun Shimohama
The role of nitric oxide in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 2001;2(2):71-81.
2001: T Kageyama; Shun Shimohama; J Kawamata
Coexistence of 2 different type I repeats.
Archives of neurology 2001;58(6):1022.
2001: Kazuhiro Honda; Shun Shimohama; Hideyuki Sawada; Takeshi Kihara; Tomoki Nakamizo; Hiroshi Shibasaki; Akinori Akaike
Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons.
Journal of neuroscience research 2001;64(5):466-75.
2001: Masakazu Ibi; Hideyuki Sawada; Miki Nakanishi; Toshiaki Kume; Hiroshi Katsuki; Shuji Kaneko; Shun Shimohama; Akinori Akaike
Protective effects of 1 alpha,25-(OH)(2)D(3) against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture.
Neuropharmacology 2001;40(6):761-71.
2001: Keisuke Hirai; Gjumrakch Aliev; Akihiko Nunomura; Hisashi Fujioka; RL Russell; Craig S Atwood; A B Johnson; Y Kress; Harry V Vinters; Massimo Tabaton; Shun Shimohama; Adam D Cash; Sandra L Siedlak; Peggy L R Harris; Paul K Jones; Robert B Petersen; George Perry; Mark A. Smith
Mitochondrial abnormalities in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(9):3017-23.
2001: Takeshi Kihara; Shun Shimohama; Hideyuki Sawada; Kazuhiro Honda; Tomoki Nakamizo; Hiroshi Shibasaki; Toshiaki Kume; Akinori Akaike
alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity.
The Journal of biological chemistry 2001;276(17):13541-6.
2001: Yoshihisa Kitamura; Y Ishida; Kazuyuki Takata; Jun-ichi Kakimura; H Mizutani; Shun Shimohama; Akinori Akaike; Tadatsugu Taniguchi
Alpha-synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal ischemia.
Brain research 2001;898(1):181-5.
2001: Shun Shimohama
[Aberrant phosphoinositide metabolism in Alzheimer's disease].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 3():818-22.
2001: M Urushitani; Tomoki Nakamizo; R Inoue; Hideyuki Sawada; Takeshi Kihara; Kazuhiro Honda; Akinori Akaike; Shun Shimohama
N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx.
Journal of neuroscience research 2001;63(5):377-87.
2001: Jun-ichi Kakimura; Yoshihisa Kitamura; Tadatsugu Taniguchi; Shun Shimohama; Peter J Gebicke-Haerter
Bip/GRP78-induced production of cytokines and uptake of amyloid-beta(1-42) peptide in microglia.
Biochemical and biophysical research communications 2001;281(1):6-10.
2001: Shun Shimohama; T Kihara
Nicotinic receptor-mediated protection against beta-amyloid neurotoxicity.
Biological psychiatry 2001;49(3):233-9.
2001: Teruyuki Tsuji; Shun Shimohama
Analysis of the proteomic profiling of brain tissue in Alzheimer's disease.
Disease markers 2001;17(4):247-57.
2000: T Kageyama; T Imura; Akinori Matsuo; Nagahiro Minato; Shun Shimohama
Distribution of the 4F2 light chain, LAT1, in the mouse brain.
Neuroreport 2000;11(17):3663-6.
2000: T Imura; Shun Shimohama
Opposing effects of adenosine on the survival of glial cells exposed to chemical ischemia.
Journal of neuroscience research 2000;62(4):539-46.
2000: Tomoki Nakamizo; M Urushitani; R Inoue; A Shinohara; Hideyuki Sawada; Kazuhiro Honda; Takeshi Kihara; Akinori Akaike; Shun Shimohama
Protection of cultured spinal motor neurons by estradiol.
Neuroreport 2000;11(16):3493-7.
2000: Yoshihisa Kitamura; Shun Shimohama; Akinori Akaike; Tadatsugu Taniguchi
The parkinsonian models: invertebrates to mammals.
Japanese journal of pharmacology 2000;84(3):237-43.
2000: T Kageyama; M Nakamura; Akinori Matsuo; Y Yamasaki; Y Takakura; M Hashida; Y Kanai; M Naito; Takashi Tsuruo; Nagahiro Minato; Shun Shimohama
The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.
Brain research 2000;879(1-2):115-21.
2000: M Urushitani; R Inoue; Tomoki Nakamizo; Hideyuki Sawada; Hiroshi Shibasaki; Shun Shimohama
Neuroprotective effect of cyclic GMP against radical-induced toxicity in cultured spinal motor neurons.
Journal of neuroscience research 2000;61(4):443-8.
2000: Shun Shimohama; Hiroko Tanino; N Kawakami; N Okamura; H Kodama; T Yamaguchi; Takao Hayakawa; Akihiko Nunomura; S Chiba; George Perry; Mark A. Smith; Shimpei Fujimoto
Activation of NADPH oxidase in Alzheimer's disease brains.
Biochemical and biophysical research communications 2000;273(1):5-9.
2000: Hideyuki Sawada; Masakazu Ibi; Takeshi Kihara; M Urushitani; Kazuhiro Honda; Miki Nakanishi; Akinori Akaike; Shun Shimohama
Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(9):1202-14.
2000: Hiroko Tanino; Shun Shimohama; Y Sasaki; Yoshio Sumida; Shimpei Fujimoto
Increase in phospholipase C-delta1 protein levels in aluminum-treated rat brains.
Biochemical and biophysical research communications 2000;271(3):620-5.
2000: Kazuhiro Honda; Hideyuki Sawada; Takeshi Kihara; M Urushitani; Tomoki Nakamizo; Akinori Akaike; Shun Shimohama
Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons.
Journal of neuroscience research 2000;60(3):321-7.
2000: Hideyuki Sawada; Masakazu Ibi; Takeshi Kihara; M Urushitani; Miki Nakanishi; Akinori Akaike; Shun Shimohama
Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons.
Journal of neurochemistry 2000;74(3):1175-84.
2000: Kenji Yamamoto; K Hashimoto; Yoshikazu Isomura; Shun Shimohama; Nobuo Kato
An IP3-assisted form of Ca2+-induced Ca2+ release in neocortical neurons.
Neuroreport 2000;11(3):535-9.
2000: Shun Shimohama
Apoptosis in Alzheimer's disease--an update.
Apoptosis : an international journal on programmed cell death 2000;5(1):9-16.
2000: Shun Shimohama
[Changes in apoptosis-regulating proteins in Alzheimer's disease: comparison with development and aging].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(3 Suppl):532-6.
2000: T Kageyama; Tomoko Oeda; T Imura; Jun Kawamata; S Suzuki; Hidekazu Tomimoto; Shun Shimohama
Coexistence of expanded CAG repeats in the MJD1a and DRPLA genes.
Neurology 2000;54(1):265-6.
2000: Toshiaki Kume; H Nishikawa; H Tomioka; Hiroshi Katsuki; Akinori Akaike; Shuji Kaneko; T Maeda; Takeshi Kihara; Shun Shimohama
p75-mediated neuroprotection by NGF against glutamate cytotoxicity in cortical cultures.
Brain research 2000;852(2):279-89.
2000: H T Kim; RL Russell; Arun K Raina; Peggy L R Harris; Sandra L Siedlak; Xiongwei Zhu; Robert B Petersen; Shun Shimohama; Mark A. Smith; George Perry
Protein disulfide isomerase in Alzheimer disease.
Antioxidants & redox signaling 2000;2(3):485-9.
2000: H Sawada; Shun Shimohama
Neuroprotective effects of estradiol in mesencephalic dopaminergic neurons.
Neuroscience and biobehavioral reviews 2000;24(1):143-7.
1999: H Sawada; Shun Shimohama
MPP(+) and glutamate in the degeneration of nigral dopaminergic neurons.
Parkinsonism & related disorders 1999;5(4):209-15.
1999: T Imura; Shun Shimohama; Masaaki Sato; H Nishikawa; K Madono; Akinori Akaike; J Kimura
Differential expression of small heat shock proteins in reactive astrocytes after focal ischemia: possible role of beta-adrenergic receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(22):9768-79.
1999: T Imura; Shun Shimohama; T Kageyama; J Kimura
Selective induction of glial glutamate transporter GLT-1 by hypertonic stress in C6 glioma cells.
Biochemical and biophysical research communications 1999;265(1):240-5.
1999: N Kawakami; T Hayakawa; Shun Shimohama; Shimpei Fujimoto
The hydroxyl radical formation system in polymorphonuclear leukocytes.
Biological & pharmaceutical bulletin 1999;22(10):1034-7.
1999: Masakazu Ibi; Hideyuki Sawada; Toshiaki Kume; Hiroshi Katsuki; Shuji Kaneko; Shun Shimohama; Akinori Akaike
Depletion of intracellular glutathione increases susceptibility to nitric oxide in mesencephalic dopaminergic neurons.
Journal of neurochemistry 1999;73(4):1696-703.
1999: Hiroko Tanino; J Yoshida; R Yamamoto; Y Kobayashi; Shun Shimohama; Shimpei Fujimoto
Abundance of low molecular weight phosphotyrosine protein phosphatase in the nerve-ending fraction in the brain.
Biological & pharmaceutical bulletin 1999;22(8):794-8.
1999: T Tsuji; Shun Shimohama; S Kamiya; T Sazuka; O Ohara
Analysis of brain proteins in Alzheimer's disease using high-resolution two-dimensional gel electrophoresis.
Journal of the neurological sciences 1999;166(2):100-6.
1999: N Kawakami; Hiroaki Takemasa; N Okamura; T Hayakawa; Shun Shimohama; Shimpei Fujimoto
Participation of cytosolic protein phosphatase in regulation of NADPH oxidase in polymorphonuclear leukocytes.
Biological & pharmaceutical bulletin 1999;22(6):556-60.
1999: Shun Shimohama; S Kamiya; T Taniguchi; Y Sumida; S Fujimoto
Differential involvement of small G proteins in Alzheimer's disease.
International journal of molecular medicine 1999;3(6):597-600.
1999: Hiroaki Kawasaki; H Fujii; Y Gotoh; T Morooka; Shun Shimohama; Eisuke Nishida; Tomoo Hirano
Requirement for mitogen-activated protein kinase in cerebellar long term depression.
The Journal of biological chemistry 1999;274(19):13498-502.
1999: Shun Shimohama; Hiroko Tanino; Shimpei Fujimoto
Changes in caspase expression in Alzheimer's disease: comparison with development and aging.
Biochemical and biophysical research communications 1999;256(2):381-4.
1999: Takeshi Kihara; Shun Shimohama; Akinori Akaike
Effects of nicotinic receptor agonists on beta-amyloid beta-sheet formation.
Japanese journal of pharmacology 1999;79(3):393-6.
1999: Yoshihisa Kitamura; Shun Shimohama; H Koike; Jun-ichi Kakimura; Yasuji Matsuoka; Yasuyuki Nomura; Peter J Gebicke-Haerter; Tadatsugu Taniguchi
Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains.
Biochemical and biophysical research communications 1999;254(3):582-6.
1999: Yoshihisa Kitamura; T Ota; Yasuji Matsuoka; I Tooyama; H Kimura; Shun Shimohama; Yasuyuki Nomura; Peter J Gebicke-Haerter; Tadatsugu Taniguchi
Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells.
Glia 1999;25(2):154-64.
1999: Shun Shimohama; Hideyuki Sawada; Takeshi Kihara; M Urushitani
[Neuronal cell death in neurodegenerative disorders and oxidative stress].
Rinshō shinkeigaku = Clinical neurology 1999;39(1):4-6.
1999: Yoshihisa Kitamura; Tadatsugu Taniguchi; Shun Shimohama
Apoptotic cell death in neurons and glial cells: implications for Alzheimer's disease.
Japanese journal of pharmacology 1999;79(1):1-5.
1998: Shun Shimohama; S Kamiya; T Taniguchi; J Kimura
Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in Alzheimer disease.
Alzheimer disease and associated disorders 1998;12(4):384-6.
1998: Hideyuki Sawada; Masakazu Ibi; Takeshi Kihara; M Urushitani; Akinori Akaike; Shun Shimohama
Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death.
Journal of neuroscience research 1998;54(5):707-19.
1998: Shun Shimohama; Shimpei Fujimoto; Yoshio Sumida; Hiroko Tanino
Differential expression of rat brain bcl-2 family proteins in development and aging.
Biochemical and biophysical research communications 1998;252(1):92-6.
1998: J Tsuda; T Kimura; Hiroko Tanino; Shun Shimohama; Shimpei Fujimoto
Characterization of high- and low-molecular weight zinc-dependent acid phosphatases in bovine liver.
Biological & pharmaceutical bulletin 1998;21(11):1218-21.
1998: M Urushitani; Shun Shimohama; Takeshi Kihara; Hideyuki Sawada; Akinori Akaike; Masakazu Ibi; R Inoue; Yoshihisa Kitamura; Takashi Taniguchi; Jun Kimura
Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron protection.
Annals of neurology 1998;44(5):796-807.
1998: Yoshihisa Kitamura; T Ota; Yasuji Matsuoka; M Okazaki; Jun-ichi Kakimura; I Tooyama; H Kimura; Shun Shimohama; Peter J Gebicke-Haerter; Yasuyuki Nomura; Tadatsugu Taniguchi
Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouse.
Neuroscience letters 1998;255(1):57-60.
1998: Shun Shimohama; Shimpei Fujimoto; Yoshio Sumida; K Akagawa; T Shirao; Yasuji Matsuoka; Tadatsugu Taniguchi
Differential expression of rat brain synaptic proteins in development and aging.
Biochemical and biophysical research communications 1998;251(1):394-8.
1998: Naoki Hattori; Kaori Kitagawa; T Higashida; Kyoko Yagyu; Shun Shimohama; T Wataya; George Perry; Mark A. Smith; Chiyoko Inagaki
CI-ATPase and Na+/K(+)-ATPase activities in Alzheimer's disease brains.
Neuroscience letters 1998;254(3):141-4.
1998: Shimpei Fujimoto; J Tsuda; N Kawakami; Hiroko Tanino; Shun Shimohama
myo-Inositol monophosphatase in the brain has zinc ion-dependent tyrosine phosphatase activity.
General pharmacology 1998;31(3):469-75.
1998: Hideyuki Sawada; Masakazu Ibi; Takeshi Kihara; M Urushitani; Akinori Akaike; Jun Kimura; Shun Shimohama
Dopamine D2-type agonists protect mesencephalic neurons from glutamate neurotoxicity: mechanisms of neuroprotective treatment against oxidative stress.
Annals of neurology 1998;44(1):110-9.
1998: Teruyuki Tsuji; Shun Shimohama; Jun Kimura; K Shimizu
m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains.
Neuroscience letters 1998;248(2):109-12.
1998: H Hasegawa; K Hiki; Tatsuya Sawamura; T Aoyama; Y Okamoto; Soichi Miwa; Shun Shimohama; J Kimura; Tomoh Masaki
Purification of a novel endothelin-converting enzyme specific for big endothelin-3.
FEBS letters 1998;428(3):304-8.
1998: Takeshi Kihara; Shun Shimohama; M Urushitani; Hideyuki Sawada; Jun Kimura; Toshiaki Kume; T Maeda; Akinori Akaike
Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity.
Brain research 1998;792(2):331-4.
1998: Shun Shimohama; S Kamiya; M Fujii; T Ogawa; M Kanamori; Jun Kawamata; T Imura; Tadatsugu Taniguchi; H Yagisawa
Mutation in the pleckstrin homology domain of the human phospholipase C-delta 1 gene is associated with loss of function.
Biochemical and biophysical research communications 1998;245(3):722-8.
1998: Shun Shimohama; Hiroko Tanino; Yoshio Sumida; J Tsuda; Shimpei Fujimoto
Alteration of myo-inositol monophosphatase in Alzheimer's disease brains.
Neuroscience letters 1998;245(3):159-62.
1998: S Tanaka; Jun Kawamata; Shun Shimohama; H Akaki; I Akiguchi; J Kimura; K Ueda
Inferior temporal lobe atrophy and APOE genotypes in Alzheimer's disease. X-ray computed tomography, magnetic resonance imaging and Xe-133 SPECT studies.
Dementia and geriatric cognitive disorders 1998;9(2):90-8.
1998: Shun Shimohama; Yoshio Sumida; Shimpei Fujimoto; Yasuji Matsuoka; Tadatsugu Taniguchi; Tadaomi Takenawa; J Kimura
Differential expression of rat brain phospholipase C isozymes in development and aging.
Biochemical and biophysical research communications 1998;243(1):210-6.
1998: T Imura; Shun Shimohama; Jun Kawamata; J Kimura
Genetic variation in the ciliary neurotrophic factor receptor alpha gene and familial amyotrophic lateral sclerosis.
Annals of neurology 1998;43(2):275.
1998: Shun Shimohama; Y Sasaki; Shimpei Fujimoto; S Kamiya; Tadatsugu Taniguchi; T Takenawa; J Kimura
Phospholipase C isozymes in the human brain and their changes in Alzheimer's disease.
Neuroscience 1998;82(4):999-1007.
1998: Shun Shimohama; T Saitoh
Differential expression of protein kinase C -alpha and -betaII in rat septum and changes following fimbria-fornix lesion.
Brain research 1998;781(1-2):343-7.
1998: Yoshihisa Kitamura; Shun Shimohama; W Kamoshima; T Ota; Yasuji Matsuoka; Yasuyuki Nomura; Mark A. Smith; George Perry; Peter J Whitehouse; Tadatsugu Taniguchi
Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease.
Brain research 1998;780(2):260-9.
1998: H Matsushima; Shun Shimohama; Jun Kawamata; S Fujimoto; T Takenawa; J Kimura
Reduction of platelet phospholipase C-delta1 activity in Alzheimer's disease associated with a specific apolipoprotein E genotype (epsilon3/epsilon3).
International journal of molecular medicine 1998;1(1):91-3.
1998: Shun Shimohama; D L Greenwald; D H Shafron; A Akaika; T Maeda; Shuji Kaneko; Jun Kimura; CE Simpkins; Arthur L Day; Edwin M Meyer
Nicotinic alpha 7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage.
Brain research 1998;779(1-2):359-63.
1998: Yoshihisa Kitamura; W Kamoshima; Shun Shimohama; Yasuyuki Nomura; Tadatsugu Taniguchi
Nitric oxide donor-induced p53-sensitive cell death is enhanced by Bcl-2 reduction in human neuroblastoma cells.
Neurochemistry international 1998;32(1):93-102.
1998: N Kawakami; Hiroaki Takemasa; T Yamaguchi; T Hayakawa; Shun Shimohama; Shimpei Fujimoto
Indication of a protein kinase C-independent pathway for NADPH oxidase activation in human neutrophils.
Archives of biochemistry and biophysics 1998;349(1):89-94.
1997: Yoshihisa Kitamura; Shun Shimohama; T Ota; Yasuji Matsuoka; Yasuyuki Nomura; Tadatsugu Taniguchi
Alteration of transcription factors NF-kappaB and STAT1 in Alzheimer's disease brains.
Neuroscience letters 1997;237(1):17-20.
1997: Yoshihisa Kitamura; T Kosaka; Shun Shimohama; Yasuyuki Nomura; Tadatsugu Taniguchi
Possible involvement of rapamycin-sensitive pathway in Bcl-2 expression in human neuroblastoma SH-SY5Y cells.
Japanese journal of pharmacology 1997;75(2):195-8.
1997: Shuji Kaneko; T Maeda; Toshiaki Kume; H Kochiyama; Akinori Akaike; Shun Shimohama; Jun Kimura
Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via alpha7-neuronal receptors and neuronal CNS receptors.
Brain research 1997;765(1):135-40.
1997: Takeshi Kihara; Shun Shimohama; Hideyuki Sawada; Jun Kimura; Toshiaki Kume; H Kochiyama; T Maeda; Akinori Akaike
Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity.
Annals of neurology 1997;42(2):159-63.
1997: Hiroaki Kawasaki; T Morooka; Shun Shimohama; Jun Kimura; Tomoo Hirano; Y Gotoh; Eisuke Nishida
Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells.
The Journal of biological chemistry 1997;272(30):18518-21.
1997: Shun Shimohama; S Kamiya; Tadatsugu Taniguchi; K Akagawa; J Kimura
Differential involvement of synaptic vesicle and presynaptic plasma membrane proteins in Alzheimer's disease.
Biochemical and biophysical research communications 1997;236(2):239-42.
1997: Yasuji Matsuoka; Yoshihisa Kitamura; R Fukunaga; Shun Shimohama; T Nabeshima; I Tooyama; H Kimura; Tadatsugu Taniguchi
In vivo hypoxia-induced neuronal damage in dentate gyrus of rat hippocampus: changes in NMDA receptors and the effect of MK-801.
Neurochemistry international 1997;30(6):533-42.
1997: Toshiaki Kume; H Kouchiyama; S Kaneko; T Maeda; Shuji Kaneko; Akinori Akaike; Shun Shimohama; Takeshi Kihara; Jun Kimura; K Wada; Shinichi Koizumi
BDNF prevents NO mediated glutamate cytotoxicity in cultured cortical neurons.
Brain research 1997;756(1-2):200-4.
1997: Yoshihisa Kitamura; Shun Shimohama; W Kamoshima; Yasuji Matsuoka; Yasuyuki Nomura; Tadatsugu Taniguchi
Changes of p53 in the brains of patients with Alzheimer's disease.
Biochemical and biophysical research communications 1997;232(2):418-21.
1997: Jun Kawamata; Shun Shimohama; S Takano; K Harada; K Ueda; J Kimura
Novel G16S (GGC-AGC) mutation in the SOD-1 gene in a patient with apparently sporadic young-onset amyotrophic lateral sclerosis.
Human mutation 1997;9(4):356-8.
1996: Hideyuki Sawada; Shun Shimohama; T Kawamura; Akinori Akaike; Y Kitamura; Tadatsugu Taniguchi; J Kimura
Mechanism of resistance to NO-induced neurotoxicity in cultured rat dopaminergic neurons.
Journal of neuroscience research 1996;46(4):509-18.
1996: N Kawakami; Shun Shimohama; T Hayakawa; Y Sumida; Shimpei Fujimoto
Tyrosine phosphorylation and translocation of phospholipase C-gamma 2 in polymorphonuclear leukocytes treated with pervanadate.
Biochimica et biophysica acta 1996;1314(1-2):167-74.
1996: Hiroshi Kawasaki; Tetsuo Moriguchi; S Matsuda; H Z Li; S Nakamura; Shun Shimohama; J Kimura; Y Gotoh; Eisuke Nishida
Ras-dependent and Ras-independent activation pathways for the stress-activated-protein-kinase cascade.
European journal of biochemistry / FEBS 1996;241(2):315-21.
1996: H Matsushima; Shun Shimohama; M Chachin; Tadatsugu Taniguchi; J Kimura
Ca2+-dependent and Ca2+-independent protein kinase C changes in the brain of patients with Alzheimer's disease.
Journal of neurochemistry 1996;67(1):317-23.
1996: M Chachin; Shun Shimohama; Y U Kunugi; Tadatsugu Taniguchi
Assessment of protein kinase C mRNA levels in Alzheimer's disease brains.
Japanese journal of pharmacology 1996;71(2):175-7.
1996: Shimpei Fujimoto; I Okano; Y Tanaka; Y Sumida; J Tsuda; N Kawakami; Shun Shimohama
Zinc-ion-dependent acid phosphatase exhibits magnesium-ion-dependent myo-inositol-1-phosphatase activity.
Biological & pharmaceutical bulletin 1996;19(6):882-5.
1996: Shun Shimohama; M Chachin; Tadatsugu Taniguchi; H Hidaka; J Kimura
Changes of neurocalcin, a calcium-binding protein, in the brain of patients with Alzheimer's disease.
Brain research 1996;716(1-2):233-6.
1996: Shun Shimohama
[Apolipoprotein E polymorphism in Alzheimer's disease].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1996;33(3):173-7.
1996: Hideyuki Sawada; T Kawamura; Shun Shimohama; Akinori Akaike; J Kimura
Different mechanisms of glutamate-induced neuronal death between dopaminergic and non-dopaminergic neurons in rat mesencephalic culture.
Journal of neuroscience research 1996;43(4):503-10.
1996: Shun Shimohama; A Akaike; J Kimura
Nicotine-induced protection against glutamate cytotoxicity. Nicotinic cholinergic receptor-mediated inhibition of nitric oxide formation.
Annals of the New York Academy of Sciences 1996;777():356-61.
1996: Hideyuki Sawada; Shun Shimohama; Y Tamura; T Kawamura; Akinori Akaike; J Kimura
Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon.
Journal of neuroscience research 1996;43(1):55-62.
1995: Shun Shimohama; Shimpei Fujimoto; M Chachin; Tadatsugu Taniguchi; George Perry; Peter J Whitehouse; J Kimura
Alterations of low molecular weight acid phosphatase protein level in Alzheimer's disease.
Brain research 1995;699(1):125-9.
1995: H Matsushima; Shun Shimohama; S Fujimoto; T Takenawa; J Kimura
Changes in platelet phospholipase C protein level and activity in Alzheimer's disease.
Neurobiology of aging 1995;16(6):895-900.
1995: T Tsukahara; M Takeda; Shun Shimohama; O Ohara; Nobuo Hashimoto
Effects of brain-derived neurotrophic factor on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in monkeys.
Neurosurgery 1995;37(4):733-9; discussion 739-41.
1995: T Maeda; Y Shimoshige; K Mizukami; Shun Shimohama; Shuji Kaneko; Akinori Akaike; Masamichi Satoh
Patch sensor detection of glutamate release evoked by a single electrical shock.
Neuron 1995;15(2):253-7.
1995: Shun Shimohama; Akinori Akaike; Y Tamura; H Matsushima; T Kume; S Fujimoto; T Takenawa; J Kimura
Glutamate-induced antigenic changes of phospholipase C-delta in cultured cortical neurons.
Journal of neuroscience research 1995;41(3):418-26.
1995: Shun Shimohama; Shimpei Fujimoto; H Matsushima; T Takenawa; Tadatsugu Taniguchi; George Perry; Peter J Whitehouse; J Kimura
Alteration of phospholipase C-delta protein level and specific activity in Alzheimer's disease.
Journal of neurochemistry 1995;64(6):2629-34.
1995: H Matsushima; Shun Shimohama
[Protein kinase C].
Nihon rinsho. Japanese journal of clinical medicine 1995;53(5):1282-6.
1995: Shun Shimohama; George Perry; P Richey; D Praprotnik; T Takenawa; K Fukami; Peter J Whitehouse; J Kimura
Characterization of the association of phospholipase C-delta with Alzheimer neurofibrillary tangles.
Brain research 1995;669(2):217-24.
1995: H Matsushima; Shun Shimohama; S Fujimoto; T Takenawa; J Kimura
Reduction of platelet phospholipase C activity in patients with Alzheimer disease.
Alzheimer disease and associated disorders 1995;9(4):213-7.
1995: Shun Shimohama; H Matsushima; Shimpei Fujimoto; T Takenawa; Tadatsugu Taniguchi; M Kameyama; J Kimura
Differential involvement of phospholipase C isozymes in Alzheimer's disease.
Gerontology 1995;41 Suppl 1():13-9.
1995: Shun Shimohama; H Matsushima
Signal transduction mechanisms in Alzheimer disease.
Alzheimer disease and associated disorders 1995;9 Suppl 2():15-22.
1994: Jun Kawamata; S Tanaka; Shun Shimohama; K Ueda; J Kimura
Apolipoprotein E polymorphism in Japanese patients with Alzheimer's disease or vascular dementia.
Journal of neurology, neurosurgery, and psychiatry 1994;57(11):1414-6.
1994: H Matsushima; Shun Shimohama; S Tanaka; T Taniguchi; M Hagiwara; H Hidaka; J Kimura
Platelet protein kinase C levels in Alzheimer's disease.
Neurobiology of aging 1994;15(6):671-4.
1994: Shun Shimohama; Shimpei Fujimoto; Tadatsugu Taniguchi; J Kimura
The endogenous substrate of low molecular weight acid phosphatase in the brain is an epidermal growth factor receptor.
Brain research 1994;662(1-2):185-8.
1994: Y Uehara-Kunugi; Shun Shimohama; H Kobayakawa; H Tamura; Tadatsugu Taniguchi
Different modulation of protein kinase C isozymes in dibutyryl cyclic AMP-differentiated PC12h cells.
Journal of neurochemistry 1994;63(1):125-32.
1994: J Kawamata; H Hasegawa; Shun Shimohama; J Kimura; S Tanaka; K Ueda
Leu106-->Val (CTC-->GTC) mutation of superoxide dismutase-1 gene in patient with familial amyotrophic lateral sclerosis in Japan.
Lancet 1994;343(8911):1501.
1994: Akinori Akaike; Y Tamura; T Yokota; Shun Shimohama; J Kimura
Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity.
Brain research 1994;644(2):181-7.
1993: Shun Shimohama; N Ogawa; Y Tamura; Akinori Akaike; T Tsukahara; H Iwata; J Kimura
Protective effect of nerve growth factor against glutamate-induced neurotoxicity in cultured cortical neurons.
Brain research 1993;632(1-2):296-302.
1993: Shun Shimohama; Y Tamura; Akinori Akaike; T Tsukahara; O Ohara; S Watanabe; J Kimura
Brain-derived neurotrophic factor pretreatment exerts a partially protective effect against glutamate-induced neurotoxicity in cultured rat cortical neurons.
Neuroscience letters 1993;164(1-2):55-8.
1993: Shun Shimohama; George Perry; P Richey; T Takenawa; Peter J Whitehouse; K Miyoshi; Toshihiko Suenaga; S Matsumoto; M Nishimura; J Kimura
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.
Neuroscience letters 1993;162(1-2):183-6.
1993: Shun Shimohama; Shimpei Fujimoto; N Tresser; P Richey; George Perry; Peter J Whitehouse; Y Homma; T Takenawa; Tadatsugu Taniguchi; Toshihiko Suenaga
Aberrant phosphoinositide metabolism in Alzheimer's disease.
Annals of the New York Academy of Sciences 1993;695():46-9.
1993: Y Yamaoka; Shun Shimohama; J Kimura; R Fukunaga; Tadatsugu Taniguchi
Neuronal damage in the rat hippocampus induced by in vivo hypoxia.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1993;45(4):205-9.
1993: Shun Shimohama; M Narita; H Matsushima; J Kimura; M Kameyama; M Hagiwara; H Hidaka; T Taniguchi
Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer's disease.
Neurology 1993;43(7):1407-13.
1993: Shun Shimohama; Shimpei Fujimoto; Tadatsugu Taniguchi; M Kameyama; J Kimura
Reduction of low-molecular-weight acid phosphatase activity in Alzheimer brains.
Annals of neurology 1993;33(6):616-21.
1993: H Matsushima; Shun Shimohama; Y Yamaoka; J Kimura; Tadatsugu Taniguchi; M Hagiwara; H Hidaka
Alteration of human platelet protein kinase C with normal aging.
Mechanisms of ageing and development 1993;69(1-2):129-36.
1993: Y Yamaoka; Shun Shimohama; J Kimura; R Fukunaga; Tadatsugu Taniguchi
Changes in protein kinase C isozymes in the rat hippocampus following transient hypoxia.
Neuroscience letters 1993;154(1-2):20-2.
1993: Shun Shimohama; T Saitoh; Fred H Gage
Changes in protein kinase C isozymes in the rat hippocampal formation following hippocampal lesion.
Hippocampus 1993;3(1):43-55.
1993: Shun Shimohama; Lisa J Fisher; F H Gage
Intracerebral grafting of genetically modified cells. Applications to a rat model of Parkinson's disease.
Advances in neurology 1993;60():744-8.
1992: Yasuhiro Nagahama; Shun Shimohama; Ryuji Kaji; Ichiro Akiguchi; J Kimura
[An adult case of transverse myelitis with erythema infectiosum].
Rinshō shinkeigaku = Clinical neurology 1992;32(9):1035-7.
1992: Shun Shimohama; Shimpei Fujimoto; Tadatsugu Taniguchi; J Kimura
Phosphatidylinositol-specific phospholipase C activity in the postmortem human brain: no alteration in Alzheimer's disease.
Brain research 1992;579(2):347-9.
1992: S Nakano; Shun Shimohama; T Saitoh; Ichiro Akiguchi; J Kimura
Localization of protein kinase C in human skeletal muscle.
Muscle & nerve 1992;15(4):496-9.
1991: W Araki; N Kitaguchi; Y Tokushima; K Ishii; H Aratake; Shun Shimohama; Shigenobu Nakamura; J Kimura
Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture.
Biochemical and biophysical research communications 1991;181(1):265-71.
1991: Shun Shimohama; Y Homma; Toshihiko Suenaga; S Fujimoto; T Taniguchi; W Araki; Y Yamaoka; T Takenawa; J Kimura
Aberrant accumulation of phospholipase C-delta in Alzheimer brains.
The American journal of pathology 1991;139(4):737-42.
1991: Shun Shimohama; Toshihiko Suenaga; W Araki; Y Yamaoaka; K Shimizu; J Kimura
Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease.
Brain research 1991;558(1):105-8.
1991: Shun Shimohama; Y Uehara-Kunugi; K Terai; Tadatsugu Taniguchi; J Kimura; T Saitoh
Expression of protein kinase C isozymes in primary neuronal cultures of the rat cerebellum.
Journal of neuroscience research 1991;29(2):261-70.
1991: Eliezer Masliah; K Yoshida; Shun Shimohama; Fred H Gage; T Saitoh
Differential expression of protein kinase C isozymes in rat glial cell cultures.
Brain research 1991;549(1):106-11.
1991: R Fukunaga; H Ninomiya; Shun Shimohama; J Kimura; M Kameyama; Tadatsugu Taniguchi
Reassessment of [3H]glutamate binding to human brain membrane preparations.
Japanese journal of pharmacology 1991;55(2):191-6.
1990: Shun Shimohama; T Saitoh; F H Gage
Differential expression of protein kinase C isozymes in rat cerebellum.
Journal of chemical neuroanatomy 1990;3(5):367-75.
1990: Eliezer Masliah; Gregory M. Cole; Shun Shimohama; Lawrence A Hansen; R DeTeresa; R D Terry; T Saitoh
Differential involvement of protein kinase C isozymes in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(7):2113-24.
1990: Haruaki Ninomiya; R Fukunaga; Tadatsugu Taniguchi; M Fujiwara; Shun Shimohama; M Kameyama
[3H]N-[1-(2-thienyl)cyclohexyl]-3,4-piperidine ([3H]TCP) binding in human frontal cortex: decreases in Alzheimer-type dementia.
Journal of neurochemistry 1990;54(2):526-32.
1990: Shun Shimohama; Haruaki Ninomiya; T Saitoh; R D Terry; R Fukunaga; Tadatsugu Taniguchi; M Fujiwara; J Kimura; M Kameyama
Changes in signal transduction in Alzheimer's disease.
Journal of neural transmission. Supplementum 1990;30():69-78.
1989: J A Wolff; Lisa J Fisher; L Xu; Hyder A Jinnah; P J Langlais; P M Iuvone; Karen L O'Malley; M B Rosenberg; Shun Shimohama; Theodore Friedmann
Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):9011-4.
1989: Shun Shimohama; M B Rosenberg; A M Fagan; J A Wolff; M P Short; X O Breakefield; Theodore Friedmann; Fred H Gage
Grafting genetically modified cells into the rat brain: characteristics of E. coli beta-galactosidase as a reporter gene.
Brain research. Molecular brain research 1989;5(4):271-8.
1989: Haruaki Ninomiya; Tadatsugu Taniguchi; M Fujiwara; Shun Shimohama; M Kameyama
Effect of in vivo exposure to hypoxia on muscarinic cholinergic receptor-coupled phosphoinositide turnover in the rat brain.
Brain research 1989;482(1):109-21.
1988: Shun Shimohama; Tadatsugu Taniguchi; M Fujiwara; M Kameyama
Changes in benzodiazepine receptors in Alzheimer-type dementia.
Annals of neurology 1988;23(4):404-6.
1988: T Tsukahara; T Taniguchi; S Miwa; Shun Shimohama; M Fujiwara; M Nishikawa; H Handa
Presynaptic and postsynaptic alpha 2-adrenergic receptors in human cerebral arteries and their alteration after subarachnoid hemorrhage.
Stroke; a journal of cerebral circulation 1988;19(1):80-3.
1987: Shun Shimohama; T Taniguchi; M Fujiwara; M Kameyama
Changes in beta-adrenergic receptor subtypes in Alzheimer-type dementia.
Journal of neurochemistry 1987;48(4):1215-21.
1986: Shun Shimohama; M Kameyama
[Alterations in cholinergic and adrenergic receptors in senile dementia of the Alzheimer's-type].
Rinshō shinkeigaku = Clinical neurology 1986;26(12):1294-7.
1986: T Tsukahara; T Taniguchi; H Usui; S Miwa; Shun Shimohama; M Fujiwara; H Handa
Sympathetic denervation and alpha adrenoceptors in dog cerebral arteries.
Naunyn-Schmiedeberg's archives of pharmacology 1986;334(4):436-43.
1986: Shun Shimohama; T Taniguchi; M Fujiwara; M Kameyama
Biochemical characterization of alpha-adrenergic receptors in human brain and changes in Alzheimer-type dementia.
Journal of neurochemistry 1986;47(4):1295-301.
1986: T Tsukahara; H Usui; T Taniguchi; Shun Shimohama; M Fujiwara; H Handa
Characterization of muscarinic cholinergic receptors in human and dog cerebral arteries.
Stroke; a journal of cerebral circulation 1986;17(2):300-5.
1986: T Tsukahara; T Taniguchi; Shun Shimohama; M Fujiwara; H Handa
Characterization of beta adrenergic receptors in human cerebral arteries and alteration of the receptors after subarachnoid hemorrhage.
Stroke; a journal of cerebral circulation 1986;17(2):202-7.
1986: Shun Shimohama; T Taniguchi; M Fujiwara; M Kameyama
Changes in nicotinic and muscarinic cholinergic receptors in Alzheimer-type dementia.
Journal of neurochemistry 1986;46(1):288-93.
1985: Shun Shimohama; T Tsukahara; T Taniguchi; M Fujiwara
The binding of 3H-acetylcholine to cholinergic receptors in bovine cerebral arteries.
Life sciences 1985;37(20):1887-93.
1985: Shun Shimohama; T Taniguchi; M Fujiwara; M Kameyama
Biochemical characterization of the nicotinic cholinergic receptors in human brain: binding of (-)-[3H]nicotine.
Journal of neurochemistry 1985;45(2):604-10.
1984: Shun Shimohama; H Suga; M Kameyama; J Shikata; T Yamamuro
[A case of ankylosing spondylitis with spinal arachnoid diverticula].
Rinshō shinkeigaku = Clinical neurology 1984;24(2):131-6.
1983: Shun Shimohama; H Kamo; I Akiguchi; A Murai; M Kameyama
[A case of secondary hemochromatosis with polyneuropathy].
Rinshō shinkeigaku = Clinical neurology 1983;23(1):63-9.