FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Hiroaki Shimokawa

Research Profile

Chemicals & Drugs

Anatomy

Disorders

Living Beings

Physiology

Coronary Circulation

Co-author Network

Publications

TOP 3
Hideaki Suzuki; Yasuyuki Taki; Akira Sumiyoshi; Yoshihiro Fukumoto; Ryuta Kawashima; Yasuharu Matsumoto; Hiroaki Shimokawa
Voxel-based morphometry and histological analysis for evaluating hippocampal damage in a rat model of cardiopulmonary resuscitation.
Masanobu Miura; Satoshi Miyata; Kotaro Nochioka; Yasuhiko Sakata; Nobuyuki Shiba; Tetsuya Hiramoto; Kan-Ichi Inoue; Tsuyoshi Takada; Jun Takahashi; Kenji Tamaki; Hiroaki Shimokawa
Prognostic impact of blood urea nitrogen changes during hospitalization in patients with acute heart failure syndrome.
Akiko Kawana; Norifumi Kubo; Motoyuki Matsui; Shin-ichi Momomura; Yasuhiro Ogata; Hisao Ogawa; Yasuhiko Sakata; Atsushi Seki; Hiroaki Shimokawa; Shozo Sueda; Tetsuya Sumiyoshi; Yusuke Takagi; Jun Takahashi; Yasuhiko Tanabe; Ryusuke Tsunoda; Satoshi Yasuda; Toshikazu Goto
Gender differences in the clinical characteristics and outcomes of patients with vasospastic angina.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Hiroaki Shimokawa (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Hideaki Suzuki; Yasuyuki Taki; Akira Sumiyoshi; Yoshihiro Fukumoto; Ryuta Kawashima; Yasuharu Matsumoto; Hiroaki Shimokawa
Voxel-based morphometry and histological analysis for evaluating hippocampal damage in a rat model of cardiopulmonary resuscitation.
NeuroImage 2013;77():215-21.
2013: Masanobu Miura; Satoshi Miyata; Kotaro Nochioka; Yasuhiko Sakata; Nobuyuki Shiba; Tetsuya Hiramoto; Kan-Ichi Inoue; Tsuyoshi Takada; Jun Takahashi; Kenji Tamaki; Hiroaki Shimokawa
Prognostic impact of blood urea nitrogen changes during hospitalization in patients with acute heart failure syndrome.
Circulation journal : official journal of the Japanese Circulation Society 2013;77(5):1221-8.
2013: Akiko Kawana; Norifumi Kubo; Motoyuki Matsui; Shin-ichi Momomura; Yasuhiro Ogata; Hisao Ogawa; Yasuhiko Sakata; Atsushi Seki; Hiroaki Shimokawa; Shozo Sueda; Tetsuya Sumiyoshi; Yusuke Takagi; Jun Takahashi; Yasuhiko Tanabe; Ryusuke Tsunoda; Satoshi Yasuda; Toshikazu Goto
Gender differences in the clinical characteristics and outcomes of patients with vasospastic angina.
Circulation journal : official journal of the Japanese Circulation Society 2013;77(5):1267-74.
2013: Yasuhiko Sakata; Hiroaki Shimokawa
Saturated fatty acid intake and cardiovascular risk.
European heart journal 2013;34(16):1178-80.
2013: Hideaki Suzuki; Akira Sumiyoshi; Ryuta Kawashima; Hiroaki Shimokawa
Different brain activation under left and right ventricular stimulation: an fMRI study in anesthetized rats.
PloS one 2013;8(2):e56990.
2013: Shunsuke Tatebe; Saori Yamamoto; Nobuhiro Yaoita; Koichiro Sugimura; Tatsuo Aoki; Yoshihiro Fukumoto; Masanobu Miura; Y Miura; Kotaro Nochioka; Kimio Satoh; Hiroaki Shimokawa
Optical coherence tomography is superior to intravascular ultrasound for diagnosis of distal-type chronic thromboembolic pulmonary hypertension.
Circulation journal : official journal of the Japanese Circulation Society 2013;77(4):1081-3.
2013: Tatsuo Aoki; Yoshihiro Fukumoto; Tetsuya Hiramoto; Kanichi Inoue; Kenta Ito; Yoshiaki Katahira; Tatsuya Komaru; Satoshi Miyata; Atsushi Obata; Kazunori Ogata; Tsuyoshi Shinozaki; Hiroyasu Sukegawa; Jun Takahashi; Tetsuo Yagi; Satoshi Yasuda; Hiroaki Shimokawa
Effect of the Great East Japan Earthquake on cardiovascular diseases--report from the 10 hospitals in the disaster area.
Circulation journal : official journal of the Japanese Circulation Society 2013;77(2):490-3.
2013: Kimio Satoh; Toru Shimizu; Koichiro Sugimura; Yusuke Takagi; Jun Takahashi; Morihiko Takeda; Shunsuke Tatebe; Ryuji Tsuburaya; Satoshi Yasuda; Tatsuo Aoki; Yoshihiro Fukumoto; Kenta Ito; Yoshitaka Ito; Yasuharu Matsumoto; Y Miura; Saori Miyamichi-Yamamoto; Masaharu Nakayama; Kotaro Nochioka; Shizuka Osaki; Hiroaki Shimokawa
Plasma cyclophilin A is a novel biomarker for coronary artery disease.
Circulation journal : official journal of the Japanese Circulation Society 2013;77(2):447-55.
2013: Yusuke Takagi; Jun Takahashi; Yasuhiko Tanabe; Ryusuke Tsunoda; Satoshi Yasuda; Toshikazu Goto; Norifumi Kubo; Motoyuki Matsui; Shin-ichi Momomura; Yasuhiro Ogata; Hisao Ogawa; Satoshi Ogawa; Toshiaki Sato; Atsushi Seki; Hiroaki Shimokawa; Shozo Sueda; Tetsuya Sumiyoshi
Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications, and prognostic impact: multicentre registry study of the Japanese Coronary Spasm Association.
European heart journal 2013;34(4):258-67.
2012: Masateru Kondo; Makoto Nakano; Koji Fukuda; Yuhi Hasebe; Yuji Wakayama; Hiroaki Shimokawa
Usefulness of the noncontact mapping system to elucidate the conduction property for the treatment of common atrial flutter.
Pacing and clinical electrophysiology : PACE 2012;35(12):1464-71.
2012: Mohamed Abdel Shafee; Yuji Wakayama; Koji Fukuda; Yuhi Hasebe; Akiko Kawana; Masateru Kondo; Makoto Nakano; Hiroaki Shimokawa
Delayed enhancement on cardiac magnetic resonance imaging is a poor prognostic factor in patients with cardiac sarcoidosis.
Journal of cardiology 2012;60(6):448-53.
2012: Denso Hayashi; Yoshimichi Imai; Keiko Ishii; Kenta Ito; Emi Kanno; Kazuyoshi Kawakami; Ryoko Maruyama; Hiroaki Shimokawa; Hiromasa Tanno; Masahiro Tachi
Low-energy extracorporeal shock wave therapy enhances skin wound healing in diabetic mice: a critical role of endothelial nitric oxide synthase.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2012;20(6):887-95.
2012: Tatsuo Aoki; Yoshihiro Fukumoto; Kenta Ito; Satoshi Miyata; Yasuhiko Sakata; Jun Takahashi; Ichiro Tsuji; Satoshi Yasuda; Hiroaki Shimokawa
The Great East Japan Earthquake Disaster and cardiovascular diseases.
European heart journal 2012;33(22):2796-803.
2012: Zhehao Dai; Yoshihiro Fukumoto; Tatsuo Aoki; Hiroaki Shimokawa
Coronary perivascular fibrosis is associated with impairment of coronary blood flow in patients with non-ischemic heart failure.
Journal of cardiology 2012;60(5):416-21.
2012: Sota Nakajima; Kazuki Noda; Junko Ohashi; Ayuko Sawada; Yoshihiro Fukumoto; Hiroaki Shimokawa
Essential role of bone marrow for microvascular endothelial and metabolic functions in mice.
Circulation research 2012;111(1):87-96.
2012: Masanobu Miura; Kotaro Nochioka; Nobuyuki Shiba; Hiroaki Shimokawa; Tsuyoshi Takada; Jun Takahashi; Haruka Kohno
Urinary albumin excretion in heart failure with preserved ejection fraction: an interim analysis of the CHART 2 study.
European journal of heart failure 2012;14(4):367-76.
2012: Ryuji Tsuburaya; Satoshi Yasuda; Takashi Shiroto; Jun Takahashi; Kentaro Aizawa; Jun Yi Gao; Hatsue Ishibashi-Ueda; Kenta Ito; Yoshitaka Ito; Yoku Kikuchi; Hiroaki Shimokawa
Long-term treatment with nifedipine suppresses coronary hyperconstricting responses and inflammatory changes induced by paclitaxel-eluting stent in pigs in vivo: possible involvement of Rho-kinase pathway.
European heart journal 2012;33(6):791-9.
2012: Taro Nihei; Kiyotaka Hao; Kenta Ito; Yoshitaka Ito; Yoku Kikuchi; Yasuharu Matsumoto; Masaharu Nakayama; Takashi Shiroto; Yusuke Takagi; Jun Takahashi; Ryuji Tsuburaya; Satoshi Yasuda; Hiroaki Shimokawa
Enhanced Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake.
Circulation journal : official journal of the Japanese Circulation Society 2012;76(12):2892-4.
2012: Kazuki Noda; Junko Ohashi; Yoshihiro Fukumoto; Maki Hosoya; Sota Nakajima; Hiroaki Shimokawa
Anti-atherogenic effects of the combination therapy with olmesartan and azelnidipine in diabetic apolipoprotein E-deficient mice.
The Tohoku journal of experimental medicine 2012;228(4):305-15.
2012: Kentaro Aizawa; Kenta Ito; Yoshitaka Ito; Yoku Kikuchi; Masaharu Nakayama; Jun Takahashi; Morihiko Takeda; Toru Takii; Ryuji Tsuburaya; Satoshi Yasuda; Hiroaki Shimokawa
Involvement of rho-kinase activation in the pathogenesis of coronary hyperconstricting responses induced by drug-eluting stents in patients with coronary artery disease.
Circulation journal : official journal of the Japanese Circulation Society 2012;76(11):2552-60.
2012: Yutaka Kagaya; Makoto Nakano; Kimio Satoh; Yasuhide Asaumi; Yoshihiro Fukumoto; Wanting Wang; Morihiko Takeda; Hiroaki Shimokawa
Current perspectives on protective roles of erythropoietin in cardiovascular system: erythropoietin receptor as a novel therapeutic target.
The Tohoku journal of experimental medicine 2012;227(2):83-91.
2012: Kotaro Nochioka; Nobuyuki Shiba; Yoshihiro Fukumoto; Masanobu Miura; Shin-ichi Tanaka; Do E Zhulanqiqige; Hiroaki Shimokawa
Ezetimibe improves endothelial function and inhibits Rho-kinase activity associated with inhibition of cholesterol absorption in humans.
Circulation journal : official journal of the Japanese Circulation Society 2012;76(8):2023-30.
2012: Makoto Nakano; Mohamed Abdel Shafee; Yuji Wakayama; Koji Fukuda; Yuhi Hasebe; Akiko Kawana; Masateru Kondo; Hiroaki Shimokawa
Increased incidence of tachyarrhythmias and heart failure hospitalization in patients with implanted cardiac devices after the great East Japan earthquake disaster.
Circulation journal : official journal of the Japanese Circulation Society 2012;76(5):1283-5.
2012: Junko Ohashi; Ayuko Sawada; Sota Nakajima; Kazuki Noda; Aya Takaki; Hiroaki Shimokawa
Mechanisms for enhanced endothelium-derived hyperpolarizing factor-mediated responses in microvessels in mice.
Circulation journal : official journal of the Japanese Circulation Society 2012;76(7):1768-79.
2012: Fukashi Serizawa; Takuya Shimizu; Hiroaki Shimokawa; Ken Tsuchida; Tetsuo Watanabe; Tsutomu Zukeran; Daijiro Akamatsu; Hitoshi Goto; Yo Hamada; Munetaka Hashimoto; Kenta Ito; Keiichiro Kawamura; Akira Sato; Susumu Satomi
Extracorporeal shock wave therapy improves the walking ability of patients with peripheral artery disease and intermittent claudication.
Circulation journal : official journal of the Japanese Circulation Society 2012;76(6):1486-93.
2012: Kiyotaka Hao; Kenta Ito; Yoshitaka Ito; Masaharu Nakayama; Nobuyuki Shiba; Hiroaki Shimokawa; Jun Takahashi; Toru Takii; Satoshi Yasuda; Yoshihiro Fukumoto
Urbanization, life style changes and the incidence/in-hospital mortality of acute myocardial infarction in Japan: report from the MIYAGI-AMI Registry Study.
Circulation journal : official journal of the Japanese Circulation Society 2012;76(5):1136-44.
2012: Shunsuke Tatebe; Koichiro Sugimura; Tatsuo Aoki; Yoshihiro Fukumoto; Y Miura; Saori Miyamichi-Yamamoto; Kotaro Nochioka; Kimio Satoh; Hiroaki Shimokawa
Clinical significance of reactive post-capillary pulmonary hypertension in patients with left heart disease.
Circulation journal : official journal of the Japanese Circulation Society 2012;76(5):1235-44.
2012: Koichiro Sugimura; Shunsuke Tatebe; Tatsuo Aoki; Yoshihiro Fukumoto; Y Miura; Saori Miyamichi-Yamamoto; Kotaro Nochioka; Kimio Satoh; Hiroaki Shimokawa
Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension.
Circulation journal : official journal of the Japanese Circulation Society 2012;76(2):485-8.
2012: Hideaki Suzuki; Satoshi Watanabe; Koji Fukuda; Shin Fukudo; Masanori Hirose; Hiroaki Shimokawa
Brain responses to cardiac electrical stimulation: a new EEG method for evaluating cardiac sensation.
The Tohoku journal of experimental medicine 2012;226(1):3-10.
2011: Nobuyuki Shiba; Hiroaki Shimokawa
Prospective care of heart failure in Japan: lessons from CHART studies.
The EPMA journal 2011;2(4):425-38.
2011: Kenta Ito; Hiroaki Shimokawa
[Low-energy extracorporeal cardiac shock wave therapy for angina pectoris].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 9():618-22.
2011: Kenta Ito; Yoshihiro Fukumoto; Hiroaki Shimokawa
Extracorporeal shock wave therapy for ischemic cardiovascular disorders.
American journal of cardiovascular drugs : drugs, devices, and other interventions 2011;11(5):295-302.
2011: Yoku Kikuchi; Masaharu Nakayama; Kentaro Aizawa; Kenta Ito; Yoshitaka Ito; Jun Takahashi; Morihiko Takeda; Ryuji Tsuburaya; Satoshi Yasuda; Hiroaki Shimokawa
Enhanced Rho-kinase activity in circulating neutrophils of patients with vasospastic angina: a possible biomarker for diagnosis and disease activity assessment.
Journal of the American College of Cardiology 2011;58(12):1231-7.
2011: Satoshi Yasuda; Hiroaki Shimokawa
[Mechanical characteristic of ischemic myocardium].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 7():131-7.
2011: Kimio Satoh; Bradford C Berk; Hiroaki Shimokawa
Vascular-derived reactive oxygen species for homeostasis and diseases.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2011;25(2):211-5.
2011: Arnold Angelo M Pineda; Hiroaki Shimokawa; Xiaojia Sun; Ryo Yamasaki; Nobutoshi Kawamura; Takuya Matsushita; Motozumi Minohara; Hua Piao; Jun-ichi Kira
Preventive and therapeutic effects of the selective Rho-kinase inhibitor fasudil on experimental autoimmune neuritis.
Journal of the neurological sciences 2011;306(1-2):115-20.
2011: Yusuke Takagi; Yasuhiko Tanabe; Ryusuke Tsunoda; Satoshi Yasuda; Toshikazu Goto; Norifumi Kubo; Motoyuki Matsui; Shin-ichi Momomura; Yasuhiro Ogata; Hisao Ogawa; Satoshi Ogawa; Toshiaki Sato; Atsushi Seki; Hiroaki Shimokawa; Shozo Sueda; Tetsuya Sumiyoshi
Clinical characteristics and long-term prognosis of vasospastic angina patients who survived out-of-hospital cardiac arrest: multicenter registry study of the Japanese Coronary Spasm Association.
Circulation. Arrhythmia and electrophysiology 2011;4(3):295-302.
2011: Wanting Wang; Morihiko Takeda; Yasuhide Asaumi; Shigefumi Fukui; Yutaka Kagaya; Hiroaki Shimokawa
Protective effects of recombinant human erythropoietin against pressure overload-induced left ventricular remodeling and premature death in mice.
The Tohoku journal of experimental medicine 2011;225(2):131-43.
2011: Saori Miyamichi-Yamamoto; Kotaro Nochioka; Kimio Satoh; Tatsuo Aoki; Zhulanqiqige Do E; Yoshihiro Fukumoto; Tomonori Ishii; Y Miura; Koichiro Sugimura; Shunsuke Tatebe; Hiroaki Shimokawa
Intensive immunosuppressive therapy improves pulmonary hemodynamics and long-term prognosis in patients with pulmonary arterial hypertension associated with connective tissue disease.
Circulation journal : official journal of the Japanese Circulation Society 2011;75(11):2668-74.
2011: Koji Fukuda; Masateru Kondo; Koji Kumagai; Masahito Miura; Makoto Nakano; Kunio Shirato; Yuji Wakayama; Jun Watanabe; Takuya Yagi; Hiroaki Shimokawa
A sodium channel blocker, pilsicainide, produces atrial post-repolarization refractoriness through the reduction of sodium channel availability.
The Tohoku journal of experimental medicine 2011;225(1):35-42.
2011: Tatsuo Aoki; Yoshihiro Fukumoto; Makoto Nakano; Masaharu Nakayama; Minako Oikawa; Kimio Satoh; Koichiro Sugimura; Hiroaki Shimokawa
Prognostic impact of myocardial interstitial fibrosis in non-ischemic heart failure. -Comparison between preserved and reduced ejection fraction heart failure.-.
Circulation journal : official journal of the Japanese Circulation Society 2011;75(11):2605-13.
2011: Yoshihiro Fukumoto; Hiroaki Shimokawa
Recent progress in the management of pulmonary hypertension.
Circulation journal : official journal of the Japanese Circulation Society 2011;75(8):1801-10.
2011: Jun Yi Gao; Kiyotaka Hao; Kenta Ito; Yoshitaka Ito; Yoku Kikuchi; Takashi Shiroto; Ryuji Tsuburaya; Satoshi Yasuda; Kentaro Aizawa; Hiroaki Shimokawa
Long-term treatment with eicosapentaenoic acid ameliorates myocardial ischemia-reperfusion injury in pigs in vivo. -Involvement of Rho-kinase pathway inhibition-.
Circulation journal : official journal of the Japanese Circulation Society 2011;75(8):1843-51.
2011: Masahito Miura; Masanori Hirose; Hideaki Endoh; Yuji Wakayama; Yoshinao Sugai; Makoto Nakano; Koji Fukuda; Chiyohiko Shindoh; Kunio Shirato; Hiroaki Shimokawa
Acceleration of Ca2+ waves in monocrotaline-induced right ventricular hypertrophy in the rat.
Circulation journal : official journal of the Japanese Circulation Society 2011;75(6):1343-9.
2011: Nobuyuki Shiba; Kotaro Nochioka; Masanobu Miura; Haruka Kohno; Hiroaki Shimokawa
Trend of westernization of etiology and clinical characteristics of heart failure patients in Japan--first report from the CHART-2 study.
Circulation journal : official journal of the Japanese Circulation Society 2011;75(4):823-33.
2011: Nobuyuki Shiba; Hiroaki Shimokawa
Chronic kidney disease and heart failure--Bidirectional close link and common therapeutic goal.
Journal of cardiology 2011;57(1):8-17.
2010: Makoto Nakano; Yoshihiro Fukumoto; Kimio Satoh; Yoshitaka Ito; Yutaka Kagaya; Naoto Ishii; Kazuo Sugamura; Hiroaki Shimokawa
OX40 ligand plays an important role in the development of atherosclerosis through vasa vasorum neovascularization.
Cardiovascular research 2010;88(3):539-46.
2010: Koichiro Sugimura; Yoshihiro Fukumoto; Jun Nawata; Huan Wang; Noriko Onoue; Tomohiro Tada; Kunio Shirato; Hiroaki Shimokawa
Hypertension promotes phosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 in rats: implication for the pathogenesis of hypertensive vascular disease.
The Tohoku journal of experimental medicine 2010;222(3):201-10.
2010: Kotaro Nochioka; Nobuyuki Shiba; Haruka Kohno; Masanobu Miura; Hiroaki Shimokawa
Both high and low body mass indexes are prognostic risks in Japanese patients with chronic heart failure: implications from the CHART study.
Journal of cardiac failure 2010;16(11):880-7.
2010: Y Miura; Yoshihiro Fukumoto; Nobuyuki Shiba; T Miura; Kazunori Shimada; Yoshitaka Iwama; Atsutoshi Takagi; Hidenori Matsusaka; Takaki Tsutsumi; Akira Yamada; Shintaro Kinugawa; Masanori Asakura; Shuichi Okamatsu; Hiroyuki Tsutsui; Hiroyuki Daida; Masunori Matsuzaki; Hitonobu Tomoike; Hiroaki Shimokawa
Prevalence and clinical implication of metabolic syndrome in chronic heart failure.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(12):2612-21.
2010: Y Miura; Yoshihiro Fukumoto; Koichiro Sugimura; Minako Oikawa; Makoto Nakano; Shunsuke Tatebe; Saori Miyamichi; Kimio Satoh; Hiroaki Shimokawa
Identification of new prognostic factors of pulmonary hypertension.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(9):1965-71.
2010: Yoshitaka Ito; Kenta Ito; Takashi Shiroto; Ryuji Tsuburaya; Gao Jun Yi; Morihiko Takeda; Yoshihiro Fukumoto; Satoshi Yasuda; Hiroaki Shimokawa
Cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia-reperfusion injury in pigs in vivo.
Coronary artery disease 2010;21(5):304-11.
2010: Shunsuke Tatebe; Yoshihiro Fukumoto; Koichiro Sugimura; Makoto Nakano; Saori Miyamichi; Kimio Satoh; Minako Oikawa; Hiroaki Shimokawa
Optical coherence tomography as a novel diagnostic tool for distal type chronic thromboembolic pulmonary hypertension.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(8):1742-4.
2010: Hiroaki Shimokawa; Masato Tsutsui
Nitric oxide synthases in the pathogenesis of cardiovascular disease: lessons from genetically modified mice.
Pflügers Archiv : European journal of physiology 2010;459(6):959-67.
2010: Hiroaki Shimokawa
Hydrogen peroxide as an endothelium-derived hyperpolarizing factor.
Pflügers Archiv : European journal of physiology 2010;459(6):915-22.
2010: Junko Ohashi; Hiroaki Shimokawa
[Novel mechanism of vasodilatation].
Nihon rinsho. Japanese journal of clinical medicine 2010;68(4):631-5.
2010: Maki Hosoya; Junko Ohashi; Ayuko Sawada; Aya Takaki; Hiroaki Shimokawa
Combination therapy with olmesartan and azelnidipine improves EDHF-mediated responses in diabetic apolipoprotein E-deficient mice.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(4):798-806.
2010: Hiroshi Fujita; Yoshihiro Fukumoto; Kenya Saji; Koichiro Sugimura; Jun Demachi; Jun Nawata; Hiroaki Shimokawa
Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension.
Heart and vessels 2010;25(2):144-9.
2010: Yoku Kikuchi; Kenta Ito; Yoshitaka Ito; Takashi Shiroto; Ryuji Tsuburaya; Kentaro Aizawa; Kiyotaka Hao; Yoshihiro Fukumoto; Jun Takahashi; Morihiko Takeda; Masaharu Nakayama; Satoshi Yasuda; Shinichi Kuriyama; Ichiro Tsuji; Hiroaki Shimokawa
Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(3):589-91.
2010: Kenta Ito; Yutaka Kagaya; Hiroaki Shimokawa
Thyroid hormone and chronically unloaded hearts.
Vascular pharmacology 2010;52(3-4):138-41.
2010: Toru Takii; Satoshi Yasuda; Jun Takahashi; Kenta Ito; Nobuyuki Shiba; Kunio Shirato; Hiroaki Shimokawa
Trends in acute myocardial infarction incidence and mortality over 30 years in Japan: report from the MIYAGI-AMI Registry Study.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(1):93-100.
2010: Satoshi Yasuda; Hiroaki Shimokawa
Potential usefulness of fish oil in the primary prevention of acute coronary syndrome.
European heart journal 2010;31(1):15-6.
2009: Takashi Shiroto; Satoshi Yasuda; Ryuji Tsuburaya; Yoshitaka Ito; Jun Takahashi; Kenta Ito; Hatsue Ishibashi-Ueda; Hiroaki Shimokawa
Role of Rho-kinase in the pathogenesis of coronary hyperconstricting responses induced by drug-eluting stents in pigs in vivo.
Journal of the American College of Cardiology 2009;54(24):2321-9.
2009: Satoshi Yasuda; Hiroaki Shimokawa
Acute myocardial infarction: the enduring challenge for cardiac protection and survival.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(11):2000-8.
2009: Kenta Ito; Yoshihiro Fukumoto; Hiroaki Shimokawa
Extracorporeal shock wave therapy as a new and non-invasive angiogenic strategy.
The Tohoku journal of experimental medicine 2009;219(1):1-9.
2009: Zhulanqiqige Do e; Yoshihiro Fukumoto; Aya Takaki; Shunsuke Tawara; Junko Ohashi; Makoto Nakano; Tomohiro Tada; Kenya Saji; Kohichiro Sugimura; Hiroshi Fujita; Yasushi Hoshikawa; Jun Nawata; Takashi Kondo; Hiroaki Shimokawa
Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(9):1731-9.
2009: Akiko Saga; Akihiko Karibe; Jun Otomo; K Iwabuchi; Toshiaki Takahashi; Hiroyuki Kanno; Junichi Kikuchi; M Keitoku; Tsuyoshi Shinozaki; Hiroaki Shimokawa
Lamin A/C gene mutations in familial cardiomyopathy with advanced atrioventricular block and arrhythmia.
The Tohoku journal of experimental medicine 2009;218(4):309-16.
2009: Yoshinao Sugai; Masahito Miura; Masanori Hirose; Yuji Wakayama; Hideaki Endoh; Taichi Nishio; Jun Watanabe; Henk E D J ter Keurs; Kunio Shirato; Hiroaki Shimokawa
Contribution of Na+/Ca2+ exchange current to the formation of delayed afterdepolarizations in intact rat ventricular muscle.
Journal of cardiovascular pharmacology 2009;53(6):517-22.
2009: Shigefumi Fukui; Yoshihiro Fukumoto; Jun Suzuki; Kenya Saji; Jun Nawata; Tsuyoshi Shinozaki; Yutaka Kagaya; Jun Watanabe; Hiroaki Shimokawa
Diabetes mellitus accelerates left ventricular diastolic dysfunction through activation of the renin-angiotensin system in hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2009;32(6):472-80.
2009: Yusuke Takagi; Satoshi Yasuda; Jun Takahashi; Morihiko Takeda; Masaharu Nakayama; Kenta Ito; Masanori Hirose; Yuji Wakayama; Koji Fukuda; Hiroaki Shimokawa
Importance of dual induction tests for coronary vasospasm and ventricular fibrillation in patients surviving out-of-hospital cardiac arrest.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(4):767-9.
2009: Mamunur Rashid; Shunsuke Tawara; Yoshihiro Fukumoto; Minoru Seto; Kazuo Yano; Hiroaki Shimokawa
Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(2):361-70.
2009: Ryoichi Arita; Yasuaki Hata; Shintaro Nakao; Takeshi Kita; Muneki Miura; Shuhei Kawahara; Souska Zandi; Lama Almulki; Faryan Tayyari; Hiroaki Shimokawa; Ali Hafezi-Moghadam; Tatsuro Ishibashi
Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.
Diabetes 2009;58(1):215-26.
2008: Tomohiro Tada; Jun Nawata; Huan Wang; Noriko Onoue; Doe Zhulanqiqige; Kenta Ito; Koichiro Sugimura; Yoshihiro Fukumoto; Hiroaki Shimokawa
Enhanced pulsatile pressure accelerates vascular smooth muscle migration: implications for atherogenesis of hypertension.
Cardiovascular research 2008;80(3):346-53.
2008: Takeshi Kita; Yasuaki Hata; Ryoichi Arita; Shuhei Kawahara; Muneki Miura; Shintaro Nakao; Yasutaka Mochizuki; Hiroshi Enaida; Yoshinobu Goto; Hiroaki Shimokawa; Ali Hafezi-Moghadam; Tatsuro Ishibashi
Role of TGF-beta in proliferative vitreoretinal diseases and ROCK as a therapeutic target.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(45):17504-9.
2008: Yoshihiro Fukumoto; Hiroaki Shimokawa
[The role of Rho-kinase pathway on PAH].
Nihon rinsho. Japanese journal of clinical medicine 2008;66(11):2091-6.
2008: Kenta Ito; Hiroaki Shimokawa
[Extracorporeal cardiac shock wave therapy for angina pectoris].
Nihon rinsho. Japanese journal of clinical medicine 2008;66(10):2019-26.
2008: Hiroaki Shimokawa; Satoshi Yasuda
Myocardial ischemia: current concepts and future perspectives.
Journal of cardiology 2008;52(2):67-78.
2008: Aya Takaki; Keiko Morikawa; Masato Tsutsui; Yoshinori Murayama; Ender Tekes; Hiroto Yamagishi; Junko Ohashi; Toyotaka Yada; Nobuyuki Yanagihara; Hiroaki Shimokawa
Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice.
The Journal of experimental medicine 2008;205(9):2053-63.
2008: Nobuhiro Yamaguchi; Koji Kumagai; Koji Fukuda; Yuji Wakayama; Yoshinao Sugai; Masanori Hirose; Hiroaki Shimokawa
Electrophysiological properties of the right atrial septum in patients with atrial tachyarrhythmias.
The Tohoku journal of experimental medicine 2008;215(1):13-22.
2008: Koji Kumagai; Koji Fukuda; Yuji Wakayama; Yoshinao Sugai; Masanori Hirose; Nobuhiro Yamaguchi; Kei Takase; Yasuteru Yamauchi; Atsushi Takahashi; Kazutaka Aonuma; Hiroaki Shimokawa
Electrocardiographic characteristics of the variants of idiopathic left ventricular outflow tract ventricular tachyarrhythmias.
Journal of cardiovascular electrophysiology 2008;19(5):495-501.
2008: Kenjiro Ikuta; Takeshi Mori; Tatsurhiro Yamamoto; Takuro Niidome; Hiroaki Shimokawa; Yoshiki Katayama
Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction.
Bioorganic & medicinal chemistry 2008;16(6):2811-8.
2008: Shigefumi Fukui; Yoshihiro Fukumoto; Jun Suzuki; Kenya Saji; Jun Nawata; Shunsuke Tawara; Tsuyoshi Shinozaki; Yutaka Kagaya; Hiroaki Shimokawa
Long-term inhibition of Rho-kinase ameliorates diastolic heart failure in hypertensive rats.
Journal of cardiovascular pharmacology 2008;51(3):317-26.
2008: Yoshihiro Fukumoto; Satoshi Yasuda; Akira Ito; Hiroaki Shimokawa
Prognostic effects of benidipine in patients with vasospastic angina: comparison with diltiazem and amlodipine.
Journal of cardiovascular pharmacology 2008;51(3):253-7.
2008: Go Anegawa; Hirofumi Kawanaka; Daisuke Yoshida; Kozo Konishi; Shohei Yamaguchi; Nao Kinjo; Akinobu Taketomi; Makoto Hashizume; Hiroaki Shimokawa; Yoshihiko Maehara
Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2008;47(3):966-77.
2008: Keiji Oi; Yoshihiro Fukumoto; Kenta Ito; Toyokazu Uwatoku; Kohtaro Abe; Takatoshi Hizume; Hiroaki Shimokawa
Extracorporeal shock wave therapy ameliorates hindlimb ischemia in rabbits.
The Tohoku journal of experimental medicine 2008;214(2):151-8.
2008: Nobuyuki Shiba; Mika Matsuki; Jun Takahashi; Tomohiro Tada; Jun Watanabe; Hiroaki Shimokawa
Prognostic importance of chronic kidney disease in Japanese patients with chronic heart failure.
Circulation journal : official journal of the Japanese Circulation Society 2008;72(2):173-8.
2008: Takuya Kishi; Yoshitaka Hirooka; Hiroaki Shimokawa; Akira Takeshita; Kenji Sunagawa
Atorvastatin reduces oxidative stress in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2008;30(1):3-11.
2008: Noriko Onoue; Jun Nawata; Tomohiro Tada; Doe Zhulanqiqige; Huan Wang; Koichiro Sugimura; Yoshihiro Fukumoto; Kunio Shirato; Hiroaki Shimokawa
Increased static pressure promotes migration of vascular smooth muscle cells: involvement of the Rho-kinase pathway.
Journal of cardiovascular pharmacology 2008;51(1):55-61.
2008: Satoshi Yasuda; Kenjiro Ikuta; Toyokazu Uwatoku; Keiji Oi; Kohtaro Abe; Fuminori Hyodo; Kengo Yoshimitsu; Kohtaro Sugimura; Hideo Utsumi; Yoshiki Katayama; Hiroaki Shimokawa
In vivo magnetic resonance imaging of atherosclerotic lesions with a newly developed Evans blue-DTPA-gadolinium contrast medium in apolipoprotein-E-deficient mice.
Journal of vascular research 2008;45(2):123-8.
2007: Satoko Shiotani; M Shimada; A Taketomi; Yuji Soejima; Tomoharu Yoshizumi; K Hashimoto; Hiroaki Shimokawa; Y Maehara
Rho-kinase as a novel gene therapeutic target in treatment of cold ischemia/reperfusion-induced acute lethal liver injury: effect on hepatocellular NADPH oxidase system.
Gene therapy 2007;14(19):1425-33.
2007: Toyokazu Uwatoku; Kenta Ito; Kohtaro Abe; Keiji Oi; Takatoshi Hizume; Kenji Sunagawa; Hiroaki Shimokawa
Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs.
Coronary artery disease 2007;18(5):397-404.
2007: Yoshihiro Fukumoto; Masahiro Mohri; Kosuke Inokuchi; Akira Ito; Yoji Hirakawa; Akihiro Masumoto; Yoshitaka Hirooka; Akira Takeshita; Hiroaki Shimokawa
Anti-ischemic effects of fasudil, a specific Rho-kinase inhibitor, in patients with stable effort angina.
Journal of cardiovascular pharmacology 2007;49(3):117-21.
2007: Bao hua Jiang; Shunsuke Tawara; Kohtaro Abe; Aya Takaki; Yoshihiro Fukumoto; Hiroaki Shimokawa
Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats.
Journal of cardiovascular pharmacology 2007;49(2):85-9.
2007: Takeshi Kita; Yasuaki Hata; Kumiko Kano; Muneki Miura; Shintaro Nakao; Yoshihiro Noda; Hiroaki Shimokawa; Tatsuro Ishibashi
Transforming growth factor-beta2 and connective tissue growth factor in proliferative vitreoretinal diseases: possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitor.
Diabetes 2007;56(1):231-8.
2006: Kohtaro Abe; Shunsuke Tawara; Keiji Oi; Takatoshi Hizume; Toyokazu Uwatoku; Yoshihiro Fukumoto; Kozo Kaibuchi; Hiroaki Shimokawa
Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice.
Journal of cardiovascular pharmacology 2006;48(6):280-5.
2006: Xiaojia Sun; Motozumi Minohara; Hitoshi Kikuchi; Takaaki Ishizu; Masahito Tanaka; Hua Piao; Manabu Osoegawa; Yasumasa Ohyagi; Hiroaki Shimokawa; Jun-ichi Kira
The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 2006;180(1-2):126-34.
2006: Takatoshi Hizume; Keiko Morikawa; Aya Takaki; Kohtaro Abe; Kenji Sunagawa; Mutsuki Amano; Kozo Kaibuchi; Chiharu Kubo; Hiroaki Shimokawa
Sustained elevation of serum cortisol level causes sensitization of coronary vasoconstricting responses in pigs in vivo: a possible link between stress and coronary vasospasm.
Circulation research 2006;99(7):767-75.
2006: Michiko Yamada; Ryuichi Tatsumi; Takashi Kikuiri; Shinpei Okamoto; Shinsuke Nonoshita; Wataru Mizunoya; Yoshihide Ikeuchi; Hiroaki Shimokawa; Kenji Sunagawa; Ronald E Allen
Matrix metalloproteinases are involved in mechanical stretch-induced activation of skeletal muscle satellite cells.
Muscle & nerve 2006;34(3):313-9.
2006: Tadashi Furuyama; Kimihiro Komori; Hiroaki Shimokawa; Yasuharu Matsumoto; Toyokazu Uwatoku; Katsuya Hirano; Yoshihiko Maehara
Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits.
Journal of vascular surgery 2006;43(6):1249-56.
2006: Muneki Miura; Yasuaki Hata; Kumiko Hirayama; Takeshi Kita; Yoshihiro Noda; Kimihiko Fujisawa; Hiroaki Shimokawa; Tatsuro Ishibashi
Critical role of the Rho-kinase pathway in TGF-beta2-dependent collagen gel contraction by retinal pigment epithelial cells.
Experimental eye research 2006;82(5):849-59.
2006: Yoshihiro Fukumoto; Akira Ito; Toyokazu Uwatoku; Tetsuya Matoba; Takuya Kishi; Haruki Tanaka; Akira Takeshita; Kenji Sunagawa; Hiroaki Shimokawa
Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease.
Coronary artery disease 2006;17(1):63-70.
2006: Ryuichi Tatsumi; Michiko Yamada; Yoshitaka Katsuki; Shinpei Okamoto; Junji Ishizaki; Wataru Mizunoya; Yoshihide Ikeuchi; Akihito Hattori; Hiroaki Shimokawa; Ronald E Allen
Low-pH preparation of skeletal muscle satellite cells can be used to study activation in vitro.
The international journal of biochemistry & cell biology 2006;38(10):1678-85.
2005: Hongtao Sun; Yoshihiro Fukumoto; Akira Ito; Hiroaki Shimokawa; Kenji Sunagawa
Coronary microvascular dysfunction in patients with microvascular angina: analysis by TIMI frame count.
Journal of cardiovascular pharmacology 2005;46(5):622-6.
2005: Hiroaki Shimokawa; Keiko Morikawa
Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in animals and humans.
Journal of molecular and cellular cardiology 2005;39(5):725-32.
2005: Hiroaki Shimokawa; Akira Takeshita
Rho-kinase is an important therapeutic target in cardiovascular medicine.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(9):1767-75.
2005: Koji Ito; Yoshitaka Hirooka; Nobuaki Hori; Yoshikuni Kimura; Yoji Sagara; Hiroaki Shimokawa; Akira Takeshita; Kenji Sunagawa
Inhibition of rho-kinase in the nucleus tractus solitarius enhances glutamate sensitivity in rats.
Hypertension 2005;46(2):360-5.
2005: Yasuhiro Eto; Hiroaki Shimokawa; Yoshihiro Fukumoto; Yasuharu Matsumoto; Kunio Morishige; Ikuko Kunihiro; Tadashi Kandabashi; Akira Takeshita
Combination therapy with cerivastatin and nifedipine improves endothelial dysfunction after balloon injury in porcine coronary arteries.
Journal of cardiovascular pharmacology 2005;46(1):1-6.
2005: Takuya Kishi; Yoshitaka Hirooka; Akihiro Masumoto; Koji Ito; Yoshikuni Kimura; Kosuke Inokuchi; Tatsuya Tagawa; Hiroaki Shimokawa; Akira Takeshita; Kenji Sunagawa
Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure.
Circulation 2005;111(21):2741-7.
2005: Keiko Morikawa; Tetsuya Matoba; Hiroshi Kubota; Makoto Hatanaka; Takako Fujiki; Shosuke Takahashi; Akira Takeshita; Hiroaki Shimokawa
Influence of diabetes mellitus, hypercholesterolemia, and their combination on EDHF-mediated responses in mice.
Journal of cardiovascular pharmacology 2005;45(5):485-90.
2005: Yingjun Zhao; Yoshihiro Fukumoto; Masahiro Mohri; Hiroaki Shimokawa; Akira Takeshita
Impact of sex and age on coronary basal tone.
Internal medicine (Tokyo, Japan) 2005;44(4):354-5.
2005: Takako Fujiki; Hiroaki Shimokawa; Keiko Morikawa; Hiroshi Kubota; Makoto Hatanaka; M A Hassan Talukder; Tetsuya Matoba; Akira Takeshita; Kenji Sunagawa
Endothelium-derived hydrogen peroxide accounts for the enhancing effect of an angiotensin-converting enzyme inhibitor on endothelium-derived hyperpolarizing factor-mediated responses in mice.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(4):766-71.
2005: Yoshitaka Hirooka; Hiroaki Shimokawa
[Perspective of sympathetic nervous system inhibitors].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 3():565-72.
2005: Yoshikuni Kimura; Yoshitaka Hirooka; Yoji Sagara; Koji Ito; Takuya Kishi; Hiroaki Shimokawa; Akira Takeshita; Kenji Sunagawa
Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress.
Circulation research 2005;96(2):252-60.
2005: Koji Ito; Yoshitaka Hirooka; Yoshikuni Kimura; Hiroaki Shimokawa; Akira Takeshita
Effects of hydroxyfasudil administered to the nucleus tractus solitarii on blood pressure and heart rate in spontaneously hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2005;27(2-3):269-77.
2005: Kohtaro Abe; Keiko Morikawa; Takatoshi Hizume; Toyokazu Uwatoku; Keiji Oi; Minoru Seto; Ichiro Ikegaki; Toshio Asano; Kozo Kaibuchi; Hiroaki Shimokawa
Prostacyclin does not inhibit rho-kinase: an implication for the treatment of pulmonary hypertension.
Journal of cardiovascular pharmacology 2005;45(2):120-4.
2005: Junko Hiroki; Hiroaki Shimokawa; Yasushi Mukai; Toshihiro Ichiki; Akira Takeshita
Divergent effects of estrogen and nicotine on Rho-kinase expression in human coronary vascular smooth muscle cells.
Biochemical and biophysical research communications 2005;326(1):154-9.
2005: Yoshitaka Hirooka; Hiroaki Shimokawa
Therapeutic potential of rho-kinase inhibitors in cardiovascular diseases.
American journal of cardiovascular drugs : drugs, devices, and other interventions 2005;5(1):31-9.
2004: Takahiro Nishida; Hiroaki Shimokawa; Keiji Oi; hideki tatewaki; Toyokazu Uwatoku; Kohtaro Abe; Yasuharu Matsumoto; Noriyoshi Kajihara; Masataka Eto; Takehisa Matsuda; Hisataka Yasui; Akira Takeshita; Kenji Sunagawa
Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in vivo.
Circulation 2004;110(19):3055-61.
2004: M A Hassan Talukder; Takako Fujiki; Keiko Morikawa; Minako Motoishi; Yoko Matsuo; Makoto Hatanaka; Masato Tsutsui; Akira Takeshita; Hiroaki Shimokawa
Endothelial nitric oxide synthase-independent effects of an ACE inhibitor on coronary flow response to bradykinin in aged mice.
Journal of cardiovascular pharmacology 2004;44(5):557-63.
2004: Keiko Morikawa; Takako Fujiki; Tetsuya Matoba; Hiroshi Kubota; Makoto Hatanaka; Shosuke Takahashi; Hiroaki Shimokawa
Important role of superoxide dismutase in EDHF-mediated responses of human mesenteric arteries.
Journal of cardiovascular pharmacology 2004;44(5):552-6.
2004: Kumiko Hirayama; Yasuaki Hata; Yoshihiro Noda; Muneki Miura; Ichiro Yamanaka; Hiroaki Shimokawa; Tatsuro Ishibashi
The involvement of the rho-kinase pathway and its regulation in cytokine-induced collagen gel contraction by hyalocytes.
Investigative ophthalmology & visual science 2004;45(11):3896-903.
2004: Hiroaki Shimokawa
[Development of next generation of non-invasive medicine].
Fukuoka igaku zasshi = Hukuoka acta medica 2004;95(10):265-8.
2004: Yoshitaka Hirooka; Hiroaki Shimokawa; Akira Takeshita
Rho-kinase, a potential therapeutic target for the treatment of hypertension.
Drug news & perspectives 2004;17(8):523-7.
2004: Junko Hiroki; Yoshihiro Fukumoto; Hiroaki Shimokawa; Yoshitaka Hirooka; Akira Takeshita
[Inhibition of Rho-kinase by fasudil preventing anginal attacks associated with spastic angina: a case report].
Journal of cardiology 2004;44(4):161-4.
2004: Akira Ito; Yoshihiro Fukumoto; Hiroaki Shimokawa
Changing characteristics of patients with vasospastic angina in the era of new calcium channel blockers.
Journal of cardiovascular pharmacology 2004;44(4):480-5.
2004: M A Hassan Talukder; Takako Fujiki; Keiko Morikawa; Minako Motoishi; Hiroshi Kubota; Tsuyoshi Morishita; Masato Tsutsui; Akira Takeshita; Hiroaki Shimokawa
Up-regulated neuronal nitric oxide synthase compensates coronary flow response to bradykinin in endothelial nitric oxide synthase-deficient mice.
Journal of cardiovascular pharmacology 2004;44(4):437-45.
2004: Koji Ito; Yoshitaka Hirooka; Yoji Sagara; Yoshikuni Kimura; Kozo Kaibuchi; Hiroaki Shimokawa; Akira Takeshita; Kenji Sunagawa
Inhibition of Rho-kinase in the brainstem augments baroreflex control of heart rate in rats.
Hypertension 2004;44(4):478-83.
2004: Kosuke Inokuchi; Akira Ito; Yoshihiro Fukumoto; Tetsuya Matoba; Akira Shiose; Takahiro Nishida; Munetaka Masuda; Shigeki Morita; Hiroaki Shimokawa
Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery.
Journal of cardiovascular pharmacology 2004;44(3):275-7.
2004: Satoko Shiotani; Mitsuo Shimada; Taketoshi Suehiro; Yuji Soejima; Tomoharu Yosizumi; Hiroaki Shimokawa; Yoshihiko Maehara
Involvement of Rho-kinase in cold ischemia-reperfusion injury after liver transplantation in rats.
Transplantation 2004;78(3):375-82.
2004: Junko Hiroki; Hiroaki Shimokawa; Midoriko Higashi; Keiko Morikawa; Tadashi Kandabashi; Natsumi Kawamura; Toru Kubota; Toshihiro Ichiki; Mutsuki Amano; Kozo Kaibuchi; Akira Takeshita
Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells.
Journal of molecular and cellular cardiology 2004;37(2):537-46.
2004: Keiji Oi; Hiroaki Shimokawa; Yoji Hirakawa; Hideki Tashiro; Ryuichi Nakaike; Toshiyuki Kozai; Keizaburo Ohzono; Kunihiko Yamamoto; Samon Koyanagi; Shuichi Okamatsu; Tsukasa Tajimi; Yutaka Kikuchi; Akira Takeshita
Postprandial increase in plasma concentrations of remnant-like particles: an independent risk factor for restenosis after percutaneous coronary intervention.
Journal of cardiovascular pharmacology 2004;44(1):66-73.
2004: Tatsuhiro Yamamoto; Kenjiro Ikuta; Keiji Oi; Kohtaro Abe; Toyokazu Uwatoku; Fuminori Hyodo; Masaharu Murata; Noboru Shigetani; Kengo Yoshimitsu; Hiroaki Shimokawa; Hideo Utsumi; Yoshiki Katayama
In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent.
Bioorganic & medicinal chemistry letters 2004;14(11):2787-90.
2004: Hiroaki Shimokawa; Tetsuya Matoba
Hydrogen peroxide as an endothelium-derived hyperpolarizing factor.
Pharmacological research : the official journal of the Italian Pharmacological Society 2004;49(6):543-9.
2004: Takuya Kishi; Yoshitaka Hirooka; Yoshikuni Kimura; Koji Ito; Hiroaki Shimokawa; Akira Takeshita
Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats.
Circulation 2004;109(19):2357-62.
2004: Tsuyoshi Hattori; Hiroaki Shimokawa; Midoriko Higashi; Junko Hiroki; Yasushi Mukai; Hiroyuki Tsutsui; Kozo Kaibuchi; Akira Takeshita
Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.
Circulation 2004;109(18):2234-9.
2004: Keiji Oi; Hiroaki Shimokawa; Junko Hiroki; Toyokazu Uwatoku; Kohtaro Abe; Yasuharu Matsumoto; Yasuhiro Nakajima; Katsuyuki Nakajima; Sanae Takeichi; Akira Takeshita
Remnant lipoproteins from patients with sudden cardiac death enhance coronary vasospastic activity through upregulation of Rho-kinase.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(5):918-22.
2004: Kohtaro Abe; Hiroaki Shimokawa; Keiko Morikawa; Toyokazu Uwatoku; Keiji Oi; Yasuharu Matsumoto; Tsuyoshi Hattori; Yutaka Nakashima; Kozo Kaibuchi; Katsuo Sueishi; Akira Takeshit
Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.
Circulation research 2004;94(3):385-93.
2004: Koji Ito; Yoshitaka Hirooka; Takuya Kishi; Yoshikuni Kimura; Kozo Kaibuchi; Hiroaki Shimokawa; Akira Takeshita
Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition.
Hypertension 2004;43(2):156-62.
2004: Tsuyoshi Hattori; Hiroaki Shimokawa; Midoriko Higashi; Junko Hiroki; Yasushi Mukai; Kozo Kaibuchi; Akira Takeshita
Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice.
Circulation research 2004;94(1):46-52.
2004: Tatsuhiro Yamamoto; Kenjiro Ikuta; Keiji Oi; Kohtaro Abe; Toyokazu Uwatoku; Masaharu Murata; Noboru Shigetani; Kengo Yoshimitsu; Hiroaki Shimokawa; Yoshiki Katayama
First functionalized MRI contrast agent recognizing vascular lesions.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2004;20(1):5-7.
2004: Yasuharu Matsumoto; Toyokazu Uwatoku; Keiji Oi; Kohtaro Abe; Tsuyoshi Hattori; Kunio Morishige; Yasuhiro Eto; Yoshihiro Fukumoto; Kei-ichiro Nakamura; Yosaburo Shibata; Takehisa Matsuda; Akira Takeshita; Hiroaki Shimokawa
Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(1):181-6.
2003: Keiko Morikawa; Hiroaki Shimokawa; Tetsuya Matoba; Hiroshi Kubota; Takaaki Akaike; M A Hassan Talukder; Makoto Hatanaka; Takako Fujiki; Hiroshi Maeda; Shosuke Takahashi; Akira Takeshita
Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization.
The Journal of clinical investigation 2003;112(12):1871-9.
2003: Tadashi Kandabashi; Hiroaki Shimokawa; Kenji Miyata; Ikuko Kunihiro; Yasuhiro Eto; Kunio Morishige; Yasuharu Matsumoto; Kazuo Obara; Koichi Nakayama; Shosuke Takahashi; Akira Takeshita
Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(12):2209-14.
2003: Kosuke Inokuchi; Yoshitaka Hirooka; Hiroaki Shimokawa; Koji Sakai; Takuya Kishi; Koji Ito; Yoshikuni Kimura; Akira Takeshita
Role of endothelium-derived hyperpolarizing factor in human forearm circulation.
Hypertension 2003;42(5):919-24.
2003: Midoriko Higashi; Hiroaki Shimokawa; Tsuyoshi Hattori; Junko Hiroki; Yasushi Mukai; Keiko Morikawa; Toshihiro Ichiki; Shosuke Takahashi; Akira Takeshita
Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system.
Circulation research 2003;93(8):767-75.
2003: Tomotake Tokunou; Rei Shibata; Hisashi Kai; Toshihiro Ichiki; Takashi Morisaki; Kae Fukuyama; Hiroki Ono; Naoko Iino; Satoko Masuda; Hiroaki Shimokawa; Kensuke Egashira; Tsutomu Imaizumi; Akira Takeshita
Apoptosis induced by inhibition of cyclic AMP response element-binding protein in vascular smooth muscle cells.
Circulation 2003;108(10):1246-52.
2003: Yasushi Mukai; Hiroaki Shimokawa; Tetsuya Matoba; Junko Hiroki; Ikuko Kunihiro; Takako Fujiki; Akira Takeshita
Acute vasodilator effects of HMG-CoA reductase inhibitors: involvement of PI3-kinase/Akt pathway and Kv channels.
Journal of cardiovascular pharmacology 2003;42(1):118-24.
2003: Tetsuya Matoba; Hiroaki Shimokawa; Keiko Morikawa; Hiroshi Kubota; Ikuko Kunihiro; Lemmy Urakami-Harasawa; Yasushi Mukai; Yoji Hirakawa; Takaaki Akaike; Akira Takeshita
Electron spin resonance detection of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in porcine coronary microvessels.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(7):1224-30.
2003: Tetsuya Shoji; Yoshikazu Yonemitsu; Kimihiro Komori; Mitsugu Tanii; Hiroyuki Itoh; Shihoko Sata; Hiroaki Shimokawa; Mamoru Hasegawa; Katsuo Sueishi; Yoshihiko Maehara
Intramuscular gene transfer of FGF-2 attenuates endothelial dysfunction and inhibits intimal hyperplasia of vein grafts in poor-runoff limbs of rabbit.
American journal of physiology. Heart and circulatory physiology 2003;285(1):H173-82.
2003: Koji Ito; Yoshitaka Hirooka; Koji Sakai; Takuya Kishi; Kozo Kaibuchi; Hiroaki Shimokawa; Akira Takeshita
Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system: possible involvement in neural mechanisms of hypertension.
Circulation research 2003;92(12):1337-43.
2003: Toshihiko Shirota; Hisataka Yasui; Hiroaki Shimokawa; Takehisa Matsuda
Fabrication of endothelial progenitor cell (EPC)-seeded intravascular stent devices and in vitro endothelialization on hybrid vascular tissue.
Biomaterials 2003;24(13):2295-302.
2003: Tetsuya Matoba; Hiroaki Shimokawa
Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in animals and humans.
Journal of pharmacological sciences 2003;92(1):1-6.
2003: Masahiro Mohri; Hiroaki Shimokawa
[Rho-kinase inhibitors for ischemic heart disease].
Nihon rinsho. Japanese journal of clinical medicine 2003;61 Suppl 5():874-9.
2003: Toyokazu Uwatoku; Hiroaki Shimokawa; Kohtaro Abe; Yasuharu Matsumoto; Tsuyoshi Hattori; Keiji Oi; Takehisa Matsuda; Kazunori Kataoka; Akira Takeshita
Application of nanoparticle technology for the prevention of restenosis after balloon injury in rats.
Circulation research 2003;92(7):e62-9.
2003: Yoshitaka Hirooka; Koji Sakai; Takuya Kishi; Koji Ito; Hiroaki Shimokawa; Akira Takeshita
Enhanced depressor response to endothelial nitric oxide synthase gene transfer into the nucleus tractus solitarii of spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26(4):325-31.
2003: Kae Fukuyama; Toshihiro Ichiki; Kotaro Takeda; Tomotake Tokunou; Naoko Iino; Satoko Masuda; Minako Ishibashi; Kensuke Egashira; Hiroaki Shimokawa; Katsuya Hirano; Hideo Kanaide; Akira Takeshita
Downregulation of vascular angiotensin II type 1 receptor by thyroid hormone.
Hypertension 2003;41(3):598-603.
2003: Hiroaki Shimokawa; Yasuhiro Eto; Kenji Miyata; Kunio Morishige; Tadashi Kandabashi; Kouji Matsushima; Akira Takeshita
Propagermanium suppresses macrophage-mediated formation of coronary arteriosclerotic lesions in pigs in vivo.
Journal of cardiovascular pharmacology 2003;41(3):372-80.
2003: Eriko Tanaka; Hiroaki Shimokawa; Hitoshi Kamiuneten; Yasuhiro Eto; Yasuharu Matsumoto; Kunio Morishige; George Koike; Masaru Yoshinaga; Kensuke Egashira; Osamu Tokunaga; Masashi Shiomi; Akira Takeshita
Disparity of MCP-1 mRNA and protein expressions between the carotid artery and the aorta in WHHL rabbits: one aspect involved in the regional difference in atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(2):244-50.
2003: Takuya Kishi; Yoshitaka Hirooka; Yoshikuni Kimura; Koji Sakai; Koji Ito; Hiroaki Shimokawa; Akira Takeshita
Overexpression of eNOS in RVLM improves impaired baroreflex control of heart rate in SHRSP. Rostral ventrolateral medulla. Stroke-prone spontaneously hypertensive rats.
Hypertension 2003;41(2):255-60.
2003: Takuya Kishi; Yoshitaka Hirooka; Yasushi Mukai; Hiroaki Shimokawa; Akira Takeshita
Atorvastatin causes depressor and sympatho-inhibitory effects with upregulation of nitric oxide synthases in stroke-prone spontaneously hypertensive rats.
Journal of hypertension 2003;21(2):379-86.
2003: Kunio Morishige; Hiroaki Shimokawa; Yasuharu Matsumoto; Yasuhiro Eto; Toyokazu Uwatoku; Kohtaro Abe; Katsuo Sueishi; Akira Takeshita
Overexpression of matrix metalloproteinase-9 promotes intravascular thrombus formation in porcine coronary arteries in vivo.
Cardiovascular research 2003;57(2):572-85.
2003: Yasuhiro Eto; Hiroaki Shimokawa; Eriko Tanaka; Kunio Morishige; Masahiro Fuchigami; Yoshiro Ishiwata; Kouji Matsushima; Akira Takeshita
Long-term treatment with propagermanium suppresses atherosclerosis in WHHL rabbits.
Journal of cardiovascular pharmacology 2003;41(2):171-7.
2003: Yoji Machida; Toru Kubota; Natsumi Kawamura; Hajime Funakoshi; Tomomi Ide; Hideo Utsumi; Yun You Li; Arthur M Feldman; Hiroyuki Tsutsui; Hiroaki Shimokawa; Akira Takeshita
Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium.
American journal of physiology. Heart and circulatory physiology 2003;284(2):H449-55.
2003: Yoshitaka Hirooka; Takuya Kishi; Koji Sakai; Hiroaki Shimokawa; Akira Takeshita
Effect of overproduction of nitric oxide in the brain stem on the cardiovascular response in conscious rats.
Journal of cardiovascular pharmacology 2003;41 Suppl 1():S119-26.
2003: Masahiro Mohri; Hiroaki Shimokawa; Yoji Hirakawa; Akihiro Masumoto; Akira Takeshita
Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm.
Journal of the American College of Cardiology 2003;41(1):15-9.
2002: Tatsuya Tagawa; Yoshitaka Hirooka; Hiroaki Shimokawa; Kiyoshi Hironaga; Koji Sakai; Jun-ichi Oyama; Akira Takeshita
Long-term treatment with eicosapentaenoic acid improves exercise-induced vasodilation in patients with coronary artery disease.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(6):823-9.
2002: Hiroaki Shimokawa; Katsuhiko Hiramori; Hiroyuki Iinuma; Saichi Hosoda; Hiroshi Kishida; Hirofumi Osada; Takashi Katagiri; Kazunobu Yamauchi; Yoshiki Yui; Takazo Minamino; Mitsuyoshi Nakashima; Kazuzo Kato
Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study.
Journal of cardiovascular pharmacology 2002;40(5):751-61.
2002: Kohtaro Abe; Hiroaki Shimokawa; Toru Kubota; Yukifumi Nawa; Akira Takeshita
Myocarditis associated with visceral larva migrans due to Toxocara canis.
Internal medicine (Tokyo, Japan) 2002;41(9):706-8.
2002: Yasushi Mukai; Hiroaki Shimokawa; Midoriko Higashi; Keiko Morikawa; Tetsuya Matoba; Junko Hiroki; Ikuko Kunihiro; Hassan M A Talukder; Akira Takeshita
Inhibition of renin-angiotensin system ameliorates endothelial dysfunction associated with aging in rats.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(9):1445-50.
2002: Yoshihiro Fukumoto; Yoshitoshi Urabe; Toshihiko Kubo; Tohru Kaku; Kensuke Egashira; Hiroaki Shimokawa; Akira Takeshita
Augmented vasodilator response to L-arginine after coronary angioplasty may attenuate restenosis.
Heart and vessels 2002;16(5):171-4.
2002: Hajime Funakoshi; Toru Kubota; Yoji Machida; Natsumi Kawamura; Arthur M Feldman; Hiroyuki Tsutsui; Hiroaki Shimokawa; Akira Takeshita
Involvement of inducible nitric oxide synthase in cardiac dysfunction with tumor necrosis factor-alpha.
American journal of physiology. Heart and circulatory physiology 2002;282(6):H2159-66.
2002: Hajime Funakoshi; Toru Kubota; Natsumi Kawamura; Yoji Machida; Arthur M Feldman; Hiroyuki Tsutsui; Hiroaki Shimokawa; Akira Takeshita
Disruption of inducible nitric oxide synthase improves beta-adrenergic inotropic responsiveness but not the survival of mice with cytokine-induced cardiomyopathy.
Circulation research 2002;90(9):959-65.
2002: Akihiro Masumoto; Masahiro Mohri; Hiroaki Shimokawa; Lemmy Urakami; Makoto Usui; Akira Takeshita
Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina.
Circulation 2002;105(13):1545-7.
2002: Yasuharu Matsumoto; Hiroaki Shimokawa; Kunio Morishige; Yasuhiro Eto; Akira Takeshita
Reduction in neointimal formation with a stent coated with multiple layers of releasable heparin in porcine coronary arteries.
Journal of cardiovascular pharmacology 2002;39(4):513-22.
2002: Mayuko Kubo-Inoue; Kensuke Egashira; Makoto Usui; Masao Takemoto; Kisho Ohtani; Makoto Katoh; Hiroaki Shimokawa; Akira Takeshita
Long-term inhibition of nitric oxide synthesis increases arterial thrombogenecity in rat carotid artery.
American journal of physiology. Heart and circulatory physiology 2002;282(4):H1478-84.
2002: Hongtao Sun; Masahiro Mohri; Hiroaki Shimokawa; Makoto Usui; Lemmy Urakami; Akira Takeshita
Coronary microvascular spasm causes myocardial ischemia in patients with vasospastic angina.
Journal of the American College of Cardiology 2002;39(5):847-51.
2002: Soko Setoguchi; Yoshitaka Hirooka; Kenichi Eshima; Hiroaki Shimokawa; Akira Takeshita
Tetrahydrobiopterin improves impaired endothelium-dependent forearm vasodilation in patients with heart failure.
Journal of cardiovascular pharmacology 2002;39(3):363-8.
2002: Hiroaki Shimokawa
Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases.
Journal of cardiovascular pharmacology 2002;39(3):319-27.
2002: Takuya Kishi; Yoshitaka Hirooka; Koji Ito; Koji Sakai; Hiroaki Shimokawa; Akira Takeshita
Cardiovascular effects of overexpression of endothelial nitric oxide synthase in the rostral ventrolateral medulla in stroke-prone spontaneously hypertensive rats.
Hypertension 2002;39(2):264-8.
2002: Chu Kataoka; Kensuke Egashira; Shujiro Inoue; Masao Takemoto; Weihua Ni; Masamichi Koyanagi; Shiro Kitamoto; Makoto Usui; Kozo Kaibuchi; Hiroaki Shimokawa; Akira Takeshita
Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats.
Hypertension 2002;39(2):245-50.
2002: Tadashi Kandabashi; Hiroaki Shimokawa; Yasushi Mukai; Tetsuya Matoba; Ikuko Kunihiro; Keiko Morikawa; Masaaki Ito; Shosuke Takahashi; Kozo Kaibuchi; Akira Takeshita
Involvement of rho-kinase in agonists-induced contractions of arteriosclerotic human arteries.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(2):243-8.
2002: Tetsuya Matoba; Hiroaki Shimokawa; Hiroshi Kubota; Keiko Morikawa; Takako Fujiki; Ikuko Kunihiro; Yasushi Mukai; Yoji Hirakawa; Akira Takeshita
Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries.
Biochemical and biophysical research communications 2002;290(3):909-13.
2001: Kunio Morishige; Hiroaki Shimokawa; Yasuhiro Eto; M Hoshijima; Kozo Kaibuchi; Akira Takeshita
In vivo gene transfer of dominant-negative rho-kinase induces regression of coronary arteriosclerosis in pigs.
Annals of the New York Academy of Sciences 2001;947():407-11.
2001: Akihiro Masumoto; Yoshitaka Hirooka; Hiroaki Shimokawa; Kiyoshi Hironaga; Soko Setoguchi; Akira Takeshita
Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans.
Hypertension 2001;38(6):1307-10.
2001: Toshihiro Ichiki; Kiyoshi Takeda; Tomotake Tokunou; Naoko Iino; Kensuke Egashira; Hiroaki Shimokawa; Katsuya Hirano; Hideo Kanaide; Akira Takeshita
Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(12):1896-901.
2001: Ryo Nakamura; Kensuke Egashira; K Arimura; Yoji Machida; Tomomi Ide; Hiroyuki Tsutsui; Hiroaki Shimokawa; Akira Takeshita
Increased inactivation of nitric oxide is involved in impaired coronary flow reserve in heart failure.
American journal of physiology. Heart and circulatory physiology 2001;281(6):H2619-25.
2001: Jun-ichi Oyama; Hiroaki Shimokawa; S Morita; H Yasui; Akira Takeshita
Elevated interleukin-1beta in pericardial fluid of patients with ischemic heart disease.
Coronary artery disease 2001;12(7):567-71.
2001: Tomotake Tokunou; Toshihiro Ichiki; Kiyoshi Takeda; Yuko Funakoshi; Naoko Iino; Hiroaki Shimokawa; Kensuke Egashira; Akira Takeshita
Thrombin induces interleukin-6 expression through the cAMP response element in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(11):1759-63.
2001: Takuya Kishi; Yoshitaka Hirooka; Koji Sakai; Hideaki Shigematsu; Hiroaki Shimokawa; Akira Takeshita
Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release.
Hypertension 2001;38(4):896-901.
2001: Keizo Ohnaka; Seiko Shimoda; Hajime Nawata; Hiroaki Shimokawa; Kozo Kaibuchi; Y Iwamoto; Ryoichi Takayanagi
Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts.
Biochemical and biophysical research communications 2001;287(2):337-42.
2001: H Tada; Kensuke Egashira; M Yamamoto; M Usui; Y Arai; Y Katsuda; Hiroaki Shimokawa; Akira Takeshita
Role of nitric oxide in regulation of coronary blood flow in response to increased metabolic demand in dogs with pacing-induced heart failure.
Japanese circulation journal 2001;65(9):827-33.
2001: Soko Setoguchi; Masahiro Mohri; Hiroaki Shimokawa; Akira Takeshita
Tetrahydrobiopterin improves endothelial dysfunction in coronary microcirculation in patients without epicardial coronary artery disease.
Journal of the American College of Cardiology 2001;38(2):493-8.
2001: Yuko Funakoshi; Toshihiro Ichiki; Hiroaki Shimokawa; Kensuke Egashira; Kiyoshi Takeda; Kozo Kaibuchi; M Takeya; T Yoshimura; Akira Takeshita
Rho-kinase mediates angiotensin II-induced monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells.
Hypertension 2001;38(1):100-4.
2001: Hiroaki Shimokawa; Kunio Morishige; Kenji Miyata; Tadashi Kandabashi; Yasuhiro Eto; Ichiro Ikegaki; Toshio Asano; Kozo Kaibuchi; Akira Takeshita
Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo.
Cardiovascular research 2001;51(1):169-77.
2001: Kiyoshi Takeda; Toshihiro Ichiki; Tomotake Tokunou; Naoko Iino; S Fujii; A Kitabatake; Hiroaki Shimokawa; Akira Takeshita
Critical role of Rho-kinase and MEK/ERK pathways for angiotensin II-induced plasminogen activator inhibitor type-1 gene expression.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(5):868-73.
2001: Kunio Morishige; Hiroaki Shimokawa; Yasuhiro Eto; Tadashi Kandabashi; Kenji Miyata; Yasuharu Matsumoto; M Hoshijima; Kozo Kaibuchi; Akira Takeshita
Adenovirus-mediated transfer of dominant-negative rho-kinase induces a regression of coronary arteriosclerosis in pigs in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(4):548-54.
2001: Yasushi Mukai; Hiroaki Shimokawa; Tetsuya Matoba; Tadashi Kandabashi; S Satoh; Junko Hiroki; Kozo Kaibuchi; Akira Takeshita
Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(6):1062-4.
2001: Hiroaki Shimokawa
Beneficial effects of eicosapentaenoic acid on endothelial vasodilator functions in animals and humans.
World review of nutrition and dietetics 2001;88():100-8.
2001: K Arimura; Kensuke Egashira; Ryo Nakamura; Tomomi Ide; Hiroyuki Tsutsui; Hiroaki Shimokawa; Akira Takeshita
Increased inactivation of nitric oxide is involved in coronary endothelial dysfunction in heart failure.
American journal of physiology. Heart and circulatory physiology 2001;280(1):H68-75.
2000: Tetsuya Matoba; Hiroaki Shimokawa; Mikio Nakashima; Yoji Hirakawa; Yasushi Mukai; Katsuya Hirano; Hideo Kanaide; Akira Takeshita
Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice.
The Journal of clinical investigation 2000;106(12):1521-30.
2000: Koji Sakai; Yoshitaka Hirooka; I Matsuo; Kenichi Eshima; Hideaki Shigematsu; Hiroaki Shimokawa; Akira Takeshita
Overexpression of eNOS in NTS causes hypotension and bradycardia in vivo.
Hypertension 2000;36(6):1023-8.
2000: K Yogo; Hiroaki Shimokawa; Hajime Funakoshi; Tadashi Kandabashi; Kenji Miyata; S Okamoto; Kensuke Egashira; P Huang; Takaaki Akaike; Akira Takeshita
Different vasculoprotective roles of NO synthase isoforms in vascular lesion formation in mice.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(11):E96-E100.
2000: Kenji Miyata; Hiroaki Shimokawa; Tadashi Kandabashi; T Higo; Kunio Morishige; Yasuhiro Eto; Kensuke Egashira; Kozo Kaibuchi; Akira Takeshita
Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(11):2351-8.
2000: Masamichi Koyanagi; Kensuke Egashira; Shiro Kitamoto; Weihua Ni; Hiroaki Shimokawa; Motohiro Takeya; T Yoshimura; Akira Takeshita
Role of monocyte chemoattractant protein-1 in cardiovascular remodeling induced by chronic blockade of nitric oxide synthesis.
Circulation 2000;102(18):2243-8.
2000: M Yamamoto; Kensuke Egashira; K Arimura; H Tada; Hiroaki Shimokawa; Akira Takeshita
Coronary vascular K+ATP channels contribute to the maintenance of myocardial perfusion in dogs with pacing-induced heart failure.
Japanese circulation journal 2000;64(9):701-7.
2000: Shiro Kitamoto; Kensuke Egashira; Chu Kataoka; Masamichi Koyanagi; Makoto Katoh; Hiroaki Shimokawa; Ryuichi Morishita; Y Kaneda; Katsuo Sueishi; Akira Takeshita
Increased activity of nuclear factor-kappaB participates in cardiovascular remodeling induced by chronic inhibition of nitric oxide synthesis in rats.
Circulation 2000;102(7):806-12.
2000: Yasuhiro Eto; Hiroaki Shimokawa; Junko Hiroki; Kunio Morishige; Tadashi Kandabashi; Yasuharu Matsumoto; Mutsuki Amano; M Hoshijima; Kozo Kaibuchi; Akira Takeshita
Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs.
American journal of physiology. Heart and circulatory physiology 2000;278(6):H1744-50.
2000: T Kuga; Hiroaki Shimokawa; Yoji Hirakawa; Y Kadokami; Y Arai; Yoshihiro Fukumoto; Koichi Kuwata; Toshiyuki Kozai; Kensuke Egashira; Akira Takeshita
Increased expression of L-type calcium channels in vascular smooth muscle cells at spastic site in a porcine model of coronary artery spasm.
Journal of cardiovascular pharmacology 2000;35(5):822-8.
2000: Tadashi Kandabashi; Hiroaki Shimokawa; Kenji Miyata; Ikuko Kunihiro; Y Kawano; Y Fukata; T Higo; Kensuke Egashira; Shosuke Takahashi; Kozo Kaibuchi; Akira Takeshita
Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta.
Circulation 2000;101(11):1319-23.
2000: Kunio Morishige; Hiroaki Shimokawa; Tohru Yamawaki; Kenji Miyata; Yasuhiro Eto; Tadashi Kandabashi; K Yogo; T Higo; Kensuke Egashira; Hikaru Ueno; Akira Takeshita
Local adenovirus-mediated transfer of C-type natriuretic peptide suppresses vascular remodeling in porcine coronary arteries in vivo.
Journal of the American College of Cardiology 2000;35(4):1040-7.
2000: Kenji Miyata; Hiroaki Shimokawa; T Higo; Tohru Yamawaki; N Katsumata; Tadashi Kandabashi; Eriko Tanaka; Y Takamura; K Yogo; Kensuke Egashira; Akira Takeshita
Sarpogrelate, a selective 5-HT2A serotonergic receptor antagonist, inhibits serotonin-induced coronary artery spasm in a porcine model.
Journal of cardiovascular pharmacology 2000;35(2):294-301.
2000: Makoto Usui; Kensuke Egashira; H Tomita; Masamichi Koyanagi; Makoto Katoh; Hiroaki Shimokawa; Motohiro Takeya; T Yoshimura; K Matsushima; Akira Takeshita
Important role of local angiotensin II activity mediated via type 1 receptor in the pathogenesis of cardiovascular inflammatory changes induced by chronic blockade of nitric oxide synthesis in rats.
Circulation 2000;101(3):305-10.
2000: Hiroaki Shimokawa
Cellular and molecular mechanisms of coronary artery spasm: lessons from animal models.
Japanese circulation journal 2000;64(1):1-12.
2000: Masamichi Koyanagi; Kensuke Egashira; Mayuko Kubo-Inoue; Makoto Usui; Shiro Kitamoto; H Tomita; Hiroaki Shimokawa; Akira Takeshita
Role of transforming growth factor-beta1 in cardiovascular inflammatory changes induced by chronic inhibition of nitric oxide synthesis.
Hypertension 2000;35(1 Pt 1):86-90.
1999: Makoto Usui; Kensuke Egashira; Shiro Kitamoto; Masamichi Koyanagi; Makoto Katoh; Chu Kataoka; Hiroaki Shimokawa; Akira Takeshita
Pathogenic role of oxidative stress in vascular angiotensin-converting enzyme activation in long-term blockade of nitric oxide synthesis in rats.
Hypertension 1999;34(4 Pt 1):546-51.
1999: Kenji Miyata; Hiroaki Shimokawa; Tohru Yamawaki; Ikuko Kunihiro; X Zhou; T Higo; Eriko Tanaka; N Katsumata; Kensuke Egashira; Akira Takeshita
Endothelial vasodilator function is preserved at the spastic/inflammatory coronary lesions in pigs.
Circulation 1999;100(13):1432-7.
1999: Hiroaki Shimokawa; Minoru Seto; N Katsumata; Mutsuki Amano; Toshiyuki Kozai; Tohru Yamawaki; Koichi Kuwata; Tadashi Kandabashi; Kensuke Egashira; Ichiro Ikegaki; Toshio Asano; Kozo Kaibuchi; Akira Takeshita
Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm.
Cardiovascular research 1999;43(4):1029-39.
1999: Y Takamura; Hiroaki Shimokawa; H Zhao; H Igarashi; Kensuke Egashira; Akira Takeshita
Important role of endothelium-derived hyperpolarizing factor in shear stress--induced endothelium-dependent relaxations in the rat mesenteric artery.
Journal of cardiovascular pharmacology 1999;34(3):381-7.
1999: X S Cheng; Hiroaki Shimokawa; H Momii; Jun-ichi Oyama; N Fukuyama; Kensuke Egashira; H Nakazawa; Akira Takeshita
Role of superoxide anion in the pathogenesis of cytokine-induced myocardial dysfunction in dogs in vivo.
Cardiovascular research 1999;42(3):651-9.
1999: H Tagawa; Hiroaki Shimokawa; Tatsuya Tagawa; M Kuroiwa-Matsumoto; Yoshitaka Hirooka; Akira Takeshita
Long-term treatment with eicosapentaenoic acid augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilatation in patients with coronary artery disease.
Journal of cardiovascular pharmacology 1999;33(4):633-40.
1999: H Zhao; Hiroaki Shimokawa; L Uragami-Harasawa; H Igarashi; Akira Takeshita
Long-term vascular effects of Nomega-nitro-L-arginine methyl ester are not soley mediated by inhibition of endothelial nitric oxide synthesis in the rat mesenteric artery.
Journal of cardiovascular pharmacology 1999;33(4):554-66.
1999: Hiroaki Shimokawa
Primary endothelial dysfunction: atherosclerosis.
Journal of molecular and cellular cardiology 1999;31(1):23-37.
1998: H Momii; Hiroaki Shimokawa; Jun-ichi Oyama; X S Cheng; R Nakamura; Kensuke Egashira; H Nakazawa; Akira Takeshita
Inhibition of adhesion molecules markedly ameliorates cytokine-induced sustained myocardial dysfunction in dogs in vivo.
Journal of molecular and cellular cardiology 1998;30(12):2637-50.
1998: Hiroaki Shimokawa; M Kuroiwa-Matsumoto; Akira Takeshita
Cytokine generation capacities of monocytes are reduced in patients with severe heart failure.
American heart journal 1998;136(6):991-1002.
1998: Makoto Katoh; Kensuke Egashira; Makoto Usui; Toshihiro Ichiki; H Tomita; Hiroaki Shimokawa; H Rakugi; Akira Takeshita
Cardiac angiotensin II receptors are upregulated by long-term inhibition of nitric oxide synthesis in rats.
Circulation research 1998;83(7):743-51.
1998: H Tomita; Kensuke Egashira; Mayuko Kubo-Inoue; Makoto Usui; Masamichi Koyanagi; Hiroaki Shimokawa; Motohiro Takeya; T Yoshimura; Akira Takeshita
Inhibition of NO synthesis induces inflammatory changes and monocyte chemoattractant protein-1 expression in rat hearts and vessels.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(9):1456-64.
1998: Tohru Yamawaki; Hiroaki Shimokawa; Toshiyuki Kozai; Kenji Miyata; T Higo; Eriko Tanaka; Kensuke Egashira; T Shiraishi; H Tamai; K Igaki; Akira Takeshita
Intramural delivery of a specific tyrosine kinase inhibitor with biodegradable stent suppresses the restenotic changes of the coronary artery in pigs in vivo.
Journal of the American College of Cardiology 1998;32(3):780-6.
1998: H Tomita; Kensuke Egashira; Y Ohara; Masao Takemoto; Masamichi Koyanagi; Makoto Katoh; H Yamamoto; K Tamaki; Hiroaki Shimokawa; Akira Takeshita
Early induction of transforming growth factor-beta via angiotensin II type 1 receptors contributes to cardiac fibrosis induced by long-term blockade of nitric oxide synthesis in rats.
Hypertension 1998;32(2):273-9.
1998: Jun-ichi Oyama; Hiroaki Shimokawa; H Momii; X Cheng; N Fukuyama; Y Arai; Kensuke Egashira; H Nakazawa; Akira Takeshita
Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo.
The Journal of clinical investigation 1998;101(10):2207-14.
1998: Masahiro Mohri; M Koyanagi; Kensuke Egashira; H Tagawa; T Ichiki; Hiroaki Shimokawa; Akira Takeshita
Angina pectoris caused by coronary microvascular spasm.
Lancet 1998;351(9110):1165-9.
1997: N Katsumata; Hiroaki Shimokawa; Minoru Seto; Toshiyuki Kozai; Tohru Yamawaki; Koichi Kuwata; Kensuke Egashira; Ichiro Ikegaki; Toshio Asano; Y Sasaki; Akira Takeshita
Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta.
Circulation 1997;96(12):4357-63.
1997: Masahiro Mohri; Kensuke Egashira; T Kuga; Hiroaki Shimokawa; Akira Takeshita
Correlations between recruitable coronary collateral flow velocities, distal occlusion pressure, and electrocardiographic changes in patients undergoing angioplasty.
Japanese circulation journal 1997;61(12):971-8.
1997: Masao Takemoto; Kensuke Egashira; H Tomita; Makoto Usui; H Okamoto; A Kitabatake; Hiroaki Shimokawa; K Sueishi; Akira Takeshita
Chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade: effects on cardiovascular remodeling in rats induced by the long-term blockade of nitric oxide synthesis.
Hypertension 1997;30(6):1621-7.
1997: L Urakami-Harasawa; Hiroaki Shimokawa; Mikio Nakashima; Kensuke Egashira; Akira Takeshita
Importance of endothelium-derived hyperpolarizing factor in human arteries.
The Journal of clinical investigation 1997;100(11):2793-9.
1997: M Alpaslan; Hiroaki Shimokawa; M Kuroiwa-Matsumoto; Yasuhiko Harasawa; Akira Takeshita
Short-term estrogen administration ameliorates dobutamine-induced myocardial ischemia in postmenopausal women with coronary artery disease.
Journal of the American College of Cardiology 1997;30(6):1466-71.
1997: Yoshihiro Fukumoto; Hiroaki Shimokawa; Toshiyuki Kozai; Toshiaki Kadokami; Koichi Kuwata; Yoshikazu Yonemitsu; T Kuga; Kensuke Egashira; Katsuo Sueishi; Akira Takeshita
Vasculoprotective role of inducible nitric oxide synthase at inflammatory coronary lesions induced by chronic treatment with interleukin-1beta in pigs in vivo.
Circulation 1997;96(9):3104-11.
1997: H Tagawa; Hiroaki Shimokawa; Tatsuya Tagawa; M Kuroiwa-Matsumoto; Yoshitaka Hirooka; Akira Takeshita
Short-term estrogen augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilation in postmenopausal women.
Journal of cardiovascular pharmacology 1997;30(4):481-8.
1997: H Tada; Kensuke Egashira; M Yamamoto; H Ueno; M Takemoto; Hiroaki Shimokawa; Akira Takeshita
Glibenclamide, a specific inhibitor of ATP-sensitive K+ channels, inhibits coronary vasodilation induced by angiotensin II-receptor antagonists.
Journal of cardiovascular pharmacology 1997;30(3):313-9.
1997: Toshiyuki Kozai; Hiroaki Shimokawa; Tohru Yamawaki; Yoshihiro Fukumoto; Toshiaki Kadokami; Koichi Kuwata; N Katsumata; Kensuke Egashira; Akira Takeshita
Platelet activating factor causes hyperconstriction at the inflammatory coronary lesions in pigs in vivo.
Coronary artery disease 1997;8(7):423-32.
1997: Masahiro Mohri; Kensuke Egashira; Tatsuya Tagawa; T Kuga; H Tagawa; Yasuhiko Harasawa; Hiroaki Shimokawa; Akira Takeshita
Basal release of nitric oxide is decreased in the coronary circulation in patients with heart failure.
Hypertension 1997;30(1 Pt 1):50-6.
1997: T Kuga; Masahiro Mohri; Kensuke Egashira; Yoji Hirakawa; Tatsuya Tagawa; Hiroaki Shimokawa; Akira Takeshita
Bradykinin-induced vasodilation of human coronary arteries in vivo: role of nitric oxide and angiotensin-converting enzyme.
Journal of the American College of Cardiology 1997;30(1):108-12.
1997: Tatsuya Tagawa; Masahiro Mohri; H Tagawa; Kensuke Egashira; Hiroaki Shimokawa; T Kuga; Yoshitaka Hirooka; Akira Takeshita
Role of nitric oxide in substance P-induced vasodilation differs between the coronary and forearm circulation in humans.
Journal of cardiovascular pharmacology 1997;29(4):546-53.
1997: Toshiyuki Kozai; Hiroaki Shimokawa; Yoshihiro Fukumoto; S Kobayashi; M K Owada; Toshiaki Kadokami; Akira Ito; Koichi Kuwata; Kensuke Egashira; T Shiraishi; H Kanaide; Akira Takeshita
Tyrosine kinase inhibitor markedly suppresses the development of coronary lesions induced by long-term treatment with platelet-derived growth factor in pigs in vivo.
Journal of cardiovascular pharmacology 1997;29(4):536-45.
1997: T Kuga; Toshiaki Kadokami; Koichi Kuwata; H Hata; Y Ohara; Kensuke Egashira; Hiroaki Shimokawa; Akira Takeshita
Central role of vascular smooth muscle hyperreactivity in coronary hyperconstriction after balloon injury in miniature pigs.
Coronary artery disease 1997;8(2):69-75.
1997: Yoshihiro Fukumoto; Hiroaki Shimokawa; Akira Ito; Toshiaki Kadokami; Yoshikazu Yonemitsu; M Aikawa; M K Owada; Kensuke Egashira; Katsuo Sueishi; R Nagai; Y Yazaki; Akira Takeshita
Inflammatory cytokines cause coronary arteriosclerosis-like changes and alterations in the smooth-muscle phenotypes in pigs.
Journal of cardiovascular pharmacology 1997;29(2):222-31.
1997: M Takemoto; Kensuke Egashira; M Usui; K Numaguchi; H Tomita; H Tsutsui; Hiroaki Shimokawa; K Sueishi; Akira Takeshita
Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats.
The Journal of clinical investigation 1997;99(2):278-87.
1996: Yoshihiro Fukumoto; Hiroaki Shimokawa; Toshiyuki Kozai; Toshiaki Kadokami; Koichi Kuwata; M K Owada; T Shiraishi; T Kuga; Kensuke Egashira; Akira Takeshita
Tyrosine kinase inhibitor suppresses the (re) stenotic changes of the coronary artery after balloon injury in pigs.
Cardiovascular research 1996;32(6):1131-40.
1996: Y Fukumoto; Yoshitoshi Urabe; Hiroaki Shimokawa; A Chishaki-Suyama; Akira Takeshita
Slowing of ventricular rate quickly improved ventricular dysfunction and exercise intolerance in patients with chronic atrial tachycardia.
Fukuoka igaku zasshi = Hukuoka acta medica 1996;87(12):274-7.
1996: Hiroaki Shimokawa; H Yasutake; Koji Fujii; M K Owada; R Nakaike; Yoshihiro Fukumoto; T Takayanagi; Taku Nagao; Kensuke Egashira; Masatoshi Fujishima; Akira Takeshita
The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation.
Journal of cardiovascular pharmacology 1996;28(5):703-11.
1996: Akira Ito; Hiroaki Shimokawa; Yoshihiro Fukumoto; Toshiaki Kadokami; R Nakaike; T Takayanagi; Kensuke Egashira; Katsuo Sueishi; Akira Takeshita
The role of fibroblast growth factor-2 in the vascular effects of interleukin-1 beta in porcine coronary arteries in vivo.
Cardiovascular research 1996;32(3):570-9.
1996: Toshiaki Kadokami; Hiroaki Shimokawa; Akira Ito; Masahiro Mohri; Akira Takeshita
Disappearance of coronary artery-ventricular fistulas after a radical operation for tetralogy of Fallot.
Japanese circulation journal 1996;60(8):624-7.
1996: Toshiaki Kadokami; Hiroaki Shimokawa; Yoshihiro Fukumoto; Akira Ito; T Takayanagi; Kensuke Egashira; Akira Takeshita
Coronary artery spasm does not depend on the intracellular calcium store but is substantially mediated by the protein kinase C-mediated pathway in a swine model with interleukin-1 beta in vivo.
Circulation 1996;94(2):190-6.
1996: Toshiaki Kadokami; Kensuke Egashira; Koichi Kuwata; Yoshihiro Fukumoto; Toshiyuki Kozai; H Yasutake; T Kuga; Hiroaki Shimokawa; Katsuo Sueishi; Akira Takeshita
Altered serotonin receptor subtypes mediate coronary microvascular hyperreactivity in pigs with chronic inhibition of nitric oxide synthesis.
Circulation 1996;94(2):182-9.
1996: R Nakaike; Hiroaki Shimokawa; M K Owada; O Tokunaga; H Yasutake; T Kishimoto; C Imada; T Shiraishi; Kensuke Egashira; Akira Takeshita
Vanadate causes synthesis of endothelium-derived NO via pertussis toxin-sensitive G protein in pigs.
The American journal of physiology 1996;271(1 Pt 2):H296-302.
1996: Y Katsuda; Kensuke Egashira; Hikaru Ueno; Y Arai; Y Akatsuka; T Kuga; Hiroaki Shimokawa; Akira Takeshita
ATP-sensitive K+ channel opener pinacidil augments beta 1-adrenoceptor-induced coronary vasodilation in dogs.
The American journal of physiology 1996;270(6 Pt 2):H2210-5.
1996: K Numaguchi; Hiroaki Shimokawa; R Nakaike; Kensuke Egashira; Akira Takeshita
PKC inhibitors prevent endothelial dysfunction after myocardial ischemia-reperfusion in rats.
The American journal of physiology 1996;270(5 Pt 2):H1634-9.
1996: Kensuke Egashira; Y Katsuda; Masahiro Mohri; T Kuga; Tatsuya Tagawa; Hiroaki Shimokawa; Akira Takeshita
Basal release of endothelium-derived nitric oxide at site of spasm in patients with variant angina.
Journal of the American College of Cardiology 1996;27(6):1444-9.
1996: M Tsutsui; Hiroaki Shimokawa; S Higuchi; S Yoshihara; K Hayashida; A Sobashima; T Kuga; T Matsuguchi; S Okamatsu
Effect of cilostazol, a novel anti-platelet drug, on restenosis after percutaneous transluminal coronary angioplasty.
Japanese circulation journal 1996;60(4):207-15.
1996: R Nakaike; Yoshitoshi Urabe; Hiroaki Shimokawa; M Kinjoh; Akira Takeshita
Recurrent myocardial infarction provoked by multiple giant coronary aneurysms. A case report.
Angiology 1996;47(3):311-4.
1996: K Numaguchi; Kensuke Egashira; M Sakata; Hiroaki Shimokawa; Akira Takeshita
Coronary vascular ATP-sensitive potassium channels are activated to a greater extent in spontaneously hypertensive rats than in Wistar-Kyoto rats.
Journal of hypertension 1996;14(2):183-9.
1996: Hiroaki Shimokawa; M Tsutsui; T Mizuki; K Hase; I Kuwaoka; N Nogami; S Okamatsu; K Nakanishi
Endothelial Gi protein expression is markedly low in human coronary microvessels.
Journal of cardiovascular pharmacology 1996;27(2):297-302.
1996: Hiroaki Shimokawa; Akira Ito; Yoshihiro Fukumoto; Toshiaki Kadokami; R Nakaike; M Sakata; T Takayanagi; Kensuke Egashira; Akira Takeshita
Chronic treatment with interleukin-1 beta induces coronary intimal lesions and vasospastic responses in pigs in vivo. The role of platelet-derived growth factor.
The Journal of clinical investigation 1996;97(3):769-76.
1996: M Tsutsui; Hiroaki Shimokawa; S Tanaka; S Yoshihara; S Higuchi; T Matsuguchi; S Okamatsu
Granulocyte activation in restenosis after percutaneous transluminal coronary angioplasty.
Japanese circulation journal 1996;60(1):27-34.
1995: K Numaguchi; Kensuke Egashira; Masao Takemoto; Toshiaki Kadokami; Hiroaki Shimokawa; Katsuo Sueishi; Akira Takeshita
Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats.
Hypertension 1995;26(6 Pt 1):957-62.
1995: Akira Ito; Kensuke Egashira; Toshiaki Kadokami; Yoshihiro Fukumoto; T Takayanagi; R Nakaike; T Kuga; Katsuo Sueishi; Hiroaki Shimokawa; Akira Takeshita
Chronic inhibition of endothelium-derived nitric oxide synthesis causes coronary microvascular structural changes and hyperreactivity to serotonin in pigs.
Circulation 1995;92(9):2636-44.
1995: Hiroaki Shimokawa; Akira Takeshita
Endothelium-dependent regulation of the cardiovascular system.
Internal medicine (Tokyo, Japan) 1995;34(10):939-46.
1995: Y Katsuda; Kensuke Egashira; Y Akatsuka; T Narishige; Hiroaki Shimokawa; Akira Takeshita
Endothelium-derived nitric oxide does not modulate metabolic coronary vasodilation induced by tachycardia in dogs.
Journal of cardiovascular pharmacology 1995;26(3):437-44.
1995: Akira Ito; Hiroaki Shimokawa; Toshiaki Kadokami; Yoshihiro Fukumoto; M K Owada; T Shiraishi; R Nakaike; T Takayanagi; Kensuke Egashira; Akira Takeshita
Tyrosine kinase inhibitor suppresses coronary arteriosclerotic changes and vasospastic responses induced by chronic treatment with interleukin-1 beta in pigs in vivo.
The Journal of clinical investigation 1995;96(3):1288-94.
1995: Y Katsuda; Kensuke Egashira; Hikaru Ueno; Y Akatsuka; T Narishige; Y Arai; T Takayanagi; Hiroaki Shimokawa; Akira Takeshita
Glibenclamide, a selective inhibitor of ATP-sensitive K+ channels, attenuates metabolic coronary vasodilatation induced by pacing tachycardia in dogs.
Circulation 1995;92(3):511-7.
1995: Tohru Fukai; Kensuke Egashira; K Numaguchi; H Hata; T Takahashi; H Kasuya; M Sakata; Hiroaki Shimokawa; Akira Takeshita
Endothelin-1 is not involved in serotonin-induced coronary spasm in a swine model.
Cardiovascular research 1995;30(2):193-9.
1995: T Kuga; Kensuke Egashira; Masahiro Mohri; Hiroyuki Tsutsui; Yasuhiko Harasawa; Yoshitoshi Urabe; S Ando; Hiroaki Shimokawa; Akira Takeshita
Bradykinin-induced vasodilation is impaired at the atherosclerotic site but is preserved at the spastic site of human coronary arteries in vivo.
Circulation 1995;92(2):183-9.
1995: R Nakaike; Hiroaki Shimokawa; H Yasutake; H Sumimoto; Akira Ito; K Numaguchi; Kensuke Egashira; K Takeshige; Akira Takeshita
Effects of L-arginine analogues on vasomotion of isolated porcine coronary arteries.
The American journal of physiology 1995;268(5 Pt 2):H1966-72.
1995: T Kuga; Y Ohara; Hiroaki Shimokawa; S Ibayashi; H Tomoike; Akira Takeshita
Inhibitory effects of aspirin on coronary hyperreactivity to autacoids after arterial balloon injury in miniature pigs.
Journal of cardiovascular pharmacology 1995;25(2):273-81.
1995: Hiroaki Shimokawa; R Nakaike; Akira Takeshita
Significance of defective endothelial signal transduction in impaired endothelium-dependent relaxation in atherosclerosis.
Gerontology 1995;41 Suppl 1():28-33.
1994: Akira Ito; Hiroaki Shimokawa; R Nakaike; Tohru Fukai; M Sakata; T Takayanagi; Kensuke Egashira; Akira Takeshita
Role of protein kinase C-mediated pathway in the pathogenesis of coronary artery spasm in a swine model.
Circulation 1994;90(5):2425-31.
1994: Y Onoyama; Hiroaki Shimokawa; K Sakai; N Honda; Hitoo Nakano
Angiogenic activity of human villi and decidua in the first trimester of pregnancy.
Fukuoka igaku zasshi = Hukuoka acta medica 1994;85(10):287-93.
1994: M Tsutsui; Hiroaki Shimokawa; S Tanaka; I Kuwaoka; K Hase; N Nogami; K Nakanishi; S Okamatsu
Endothelial Gi protein in human coronary arteries.
European heart journal 1994;15(9):1261-6.
1994: Y Akatsuka; Kensuke Egashira; Y Katsuda; T Narishige; Hikaru Ueno; Hiroaki Shimokawa; Akira Takeshita
ATP sensitive potassium channels are involved in adenosine A2 receptor mediated coronary vasodilatation in the dog.
Cardiovascular research 1994;28(6):906-11.
1993: H Tagawa; H Tomoike; W Mitsuoka; S Satoh; T Kuga; Hiroaki Shimokawa; M Nakamura; Akira Takeshita
Hyperreactivity of aortic smooth muscle to serotonin is related to the presence of atheroma in Watanabe heritable hyperlipidaemic rabbits.
Cardiovascular research 1993;27(12):2164-9.
1993: M Tsutsui; Hiroaki Shimokawa; S Yoshihara; A Sobashima; K Hayashida; S Higuchi; K Yamamoto; T Matsuguchi; S Okamatsu
Intracellular magnesium deficiency in acute myocardial infarction.
Japanese heart journal 1993;34(4):391-401.
1993: H Tashiro; Hiroaki Shimokawa; S Koyanagi; Akira Takeshita
Clinical characteristics of patients with spontaneous remission of variant angina.
Japanese circulation journal 1993;57(2):117-22.
1993: Hiroaki Shimokawa
[Endothelial repair process and endothelium-dependent relaxation--endothelial signal transduction system and its abnormality].
Japanese circulation journal 1993;57 Suppl 4():1189-92.
1992: M Tsutsui; T Matsuguchi; H Tsutsui; T Yoshida; S Yoshihara; K Yamamoto; R Hisanou; Hiroaki Shimokawa; S Okamatsu
Alcohol-induced sinus bradycardia and hypotension in patients with syncope.
Japanese heart journal 1992;33(6):875-9.
1990: H Maeda; Hiroaki Shimokawa; S Satoh; Y Yamaguchi; S Hisanaga; T Koyanagi; Hitoo Nakano
Safety of cordocentesis under ultrasound guidance for fetal blood sampling.
Nihon Sanka Fujinka Gakkai zasshi 1990;42(2):199-202.
1989: Y Kashiwabara; Y Onoyama; Hiroaki Shimokawa; S Hisanaga; Hitoo Nakano
A new method for measurement of surfactant specific apoprotein in amniotic fluid.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1989;29(2):147-52.
1989: H Maeda; Hiroaki Shimokawa; Y Yamaguchi; K Sueishi; Hitoo Nakano
The influence of pleural effusion on pulmonary growth in the human fetus.
Journal of perinatal medicine 1989;17(3):231-6.
1989: S Miyamoto; Hiroaki Shimokawa; H Sumioki; Hitoo Nakano
Physiologic role of endogenous human atrial natriuretic peptide in preeclamptic pregnancies.
American journal of obstetrics and gynecology 1989;160(1):155-9.
1988: S Miyamoto; Hiroaki Shimokawa; A Touno; T Kurokawa; Hitoo Nakano
Characteristics of changes in blood circulation induced by cold stimulation in pre-eclamptic women.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1988;27(2):159-64.
1988: H Maeda; Hiroaki Shimokawa; S Satoh; Hitoo Nakano; T Nunoue
Nonimmunologic hydrops fetalis resulting from intrauterine human parvovirus B-19 infection: report of two cases.
Obstetrics and gynecology 1988;72(3 Pt 2):482-5.
1988: Hiroaki Shimokawa; K Hara; A Fukuda; Hitoo Nakano
Idiopathic hydrops fetalis successfully treated in utero.
Obstetrics and gynecology 1988;71(6 Pt 2):984-6.
1988: S Miyamoto; Hiroaki Shimokawa; T Kurokawa; Hitoo Nakano
How does pre-eclampsia influence thermal conductivity of the skin?
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1988;26(3):361-5.
1988: Hiroaki Shimokawa; K Nagasawa; T Irie; S Egashira; Kensuke Egashira; T Sagara; Y Kikuchi; M Nakamura
Clinical characteristics and long-term prognosis of patients with variant angina. A comparative study between western and Japanese populations.
International journal of cardiology 1988;18(3):331-49.
1988: S Miyamoto; Hiroaki Shimokawa; H Sumioki; A Touno; Hitoo Nakano
Circadian rhythm of plasma atrial natriuretic peptide, aldosterone, and blood pressure during the third trimester in normal and preeclamptic pregnancies.
American journal of obstetrics and gynecology 1988;158(2):393-9.
1988: T Kurokawa; S Miyamoto; Y Uchiumi; J Higashihara; Hiroaki Shimokawa; Hitoo Nakano
[The influence of gestational edema on maternal and perinatal outcome].
Nihon Sanka Fujinka Gakkai zasshi 1988;40(1):9-13.
1988: H Maeda; Hiroaki Shimokawa; Hitoo Nakano
Effects of intrauterine treatment on nonimmunologic hydrops fetalis.
Fetal therapy 1988;3(4):198-209.
1988: S Kubota; T Koyanagi; E Hori; K Hara; Hiroaki Shimokawa; Hitoo Nakano
Homeothermal adjustment in the immediate postdelivered infant monitored by continuous and simultaneous measurement of core and peripheral body temperatures.
Biology of the neonate 1988;54(2):79-85.
1988: Hiroaki Shimokawa; K Hara; H Maeda; S Miyamoto; T Koyanagi; Hitoo Nakano
Intrauterine treatment of idiopathic hydrops fetalis.
Journal of perinatal medicine 1988;16(2):133-8.
1988: Hiroaki Shimokawa; H Sumioki; S Miyamoto; H Maeda; Y Yamaguchi; Hitoo Nakano
Is human atrial natriuretic peptide in fetal blood useful as a parameter to detect the decompensate state of the fetal heart?
Journal of perinatal medicine 1988;16(5-6):485-6.
1987: Hitoo Nakano; Hiroaki Shimokawa
[Medical care system for mother, fetus and newborn--what should be in mind for systematization].
Nihon Sanka Fujinka Gakkai zasshi 1987;39(11):2081-5.
1987: H Nakahara; T Koyanagi; H Teraoka; Hiroaki Shimokawa; K Hara; Hitoo Nakano
Microcomputer-based local area network system for controlling information on perinatal medicine.
International journal of bio-medical computing 1987;21(2):83-93.
1987: S Nabeyama; H Tomoike; K Hisano; Hiroaki Shimokawa; T Inoue; H Yamamoto; M Nakamura
Collateral function modified by glyceryl trinitrate and dipyridamole during coronary occlusion in conscious dogs.
Cardiovascular research 1987;21(3):177-87.
1987: Y Yamaguchi; Hiroaki Shimokawa; E Hori; N Matsumoto; Hitoo Nakano; Sachiyo Suita; J Kukita
Measurement of the fetal urine production rate using real-time ultrasound in fetuses with bilateral hydronephrosis.
Fetal therapy 1987;2(4):197-202.
1986: Y Kashiwabara; H Maeda; Y Yamaguchi; Hiroaki Shimokawa; S Hisanaga; Hitoo Nakano
[Studies on surface tension of amniotic fluid with special emphasis on evaluating fetal lung maturity].
Nihon Sanka Fujinka Gakkai zasshi 1986;38(3):346-54.
1985: Hiroaki Shimokawa; S Hisanaga; S Maesato; Y Kashiwabara; H Maeda; S Oki; Hitoo Nakano
Correlation between amniotic fluid lecithin-sphingomyelin (L/S) ratio and optical density measured after centrifugation at varying forces.
Asia-Oceania journal of obstetrics and gynaecology / AOFOG 1985;11(2):265-70.
1985: T Umezu; S Hisanaga; Hiroaki Shimokawa; Y Kashiwabara; S Maesato
Origin of lysozyme in amniotic fluid.
Nihon Sanka Fujinka Gakkai zasshi 1985;37(2):301-3.
1984: S Hisanaga; Hiroaki Shimokawa; Y Kashiwabara; S Maesato; Hitoo Nakano
Unexpectedly low lecithin/sphingomyelin ratio associated with fetal diaphragmatic hernia.
American journal of obstetrics and gynecology 1984;149(8):905-6.
1984: Y Kashiwabara; Hiroaki Shimokawa; S Maesato; S Hisanaga; Hitoo Nakano
[Origin of low molecular weight protein in amniotic fluid].
Nihon Sanka Fujinka Gakkai zasshi 1984;36(5):705-9.
1983: S Hisanaga; Hiroaki Shimokawa; T Kurokawa; S Maesato; Hitoo Nakano
Relation of the site of congenital upper gastrointestinal obstruction to amniotic fluid bilirubin concentration.
Asia-Oceania journal of obstetrics and gynaecology / AOFOG 1983;9(4):435-8.
1983: S Hisanaga; Hiroaki Shimokawa; T Matsuo; T Umezu; S Maesato; Y Kashiwabara; Hitoo Nakano
Evaluation of amniocentesis guided by real-time ultrasonic tomography.
Nihon Sanka Fujinka Gakkai zasshi 1983;35(7):981-4.
1982: S Hisanaga; T Umezu; Hiroaki Shimokawa; S Maesato
Amniotic fluid lysozyme content in normal and abnormal pregnancy.
Nihon Sanka Fujinka Gakkai zasshi 1982;34(4):541-4.
1981: S Maesato; Hiroaki Shimokawa; S Hisanaga
[Changes of the amniotic fluid proteins on the basis of molecular weight (author's transl)].
Nihon Sanka Fujinka Gakkai zasshi 1981;33(12):2047-54.