Hiroaki Shimokawa

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Coronary Circulation

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Yasuda Satoshi; Shimokawa Hiroaki
Acute myocardial infarction: the enduring challenge for cardiac protection and survival.
Ito Kenta; Fukumoto Yoshihiro; Shimokawa Hiroaki
Extracorporeal shock wave therapy as a new and non-invasive angiogenic strategy.
Do e Zhulanqiqige; Fukumoto Yoshihiro; Takaki Aya; Tawara Shunsuke; Ohashi Junko; Nakano Makoto; Tada Tomohiro; Saji Kenya; Sugimura Kohichiro; Fujita Hiroshi; Hoshikawa Yasushi; Nawata Jun; Kondo Takashi; Shimokawa Hiroaki
Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension.

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All Publications

2009: Yasuda Satoshi; Shimokawa Hiroaki
Acute myocardial infarction: the enduring challenge for cardiac protection and survival.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(11):2000-8.
2009: Ito Kenta; Fukumoto Yoshihiro; Shimokawa Hiroaki
Extracorporeal shock wave therapy as a new and non-invasive angiogenic strategy.
The Tohoku journal of experimental medicine 2009;219(1):1-9.
2009: Do e Zhulanqiqige; Fukumoto Yoshihiro; Takaki Aya; Tawara Shunsuke; Ohashi Junko; Nakano Makoto; Tada Tomohiro; Saji Kenya; Sugimura Kohichiro; Fujita Hiroshi; Hoshikawa Yasushi; Nawata Jun; Kondo Takashi; Shimokawa Hiroaki
Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(9):1731-9.
2009: Saga Akiko; Karibe Akihiko; Otomo Jun; Iwabuchi Kaoru; Takahashi Toshiaki; Kanno Hiroyuki; Kikuchi Junichi; Keitoku Mitsumasa; Shinozaki Tsuyoshi; Shimokawa Hiroaki
Lamin A/C gene mutations in familial cardiomyopathy with advanced atrioventricular block and arrhythmia.
The Tohoku journal of experimental medicine 2009;218(4):309-16.
2009: Sugai Yoshinao; Miura Masahito; Hirose Masanori; Wakayama Yuji; Endoh Hideaki; Nishio Taichi; Watanabe Jun; ter Keurs Henk E D J; Shirato Kunio; Shimokawa Hiroaki
Contribution of Na+/Ca2+ exchange current to the formation of delayed afterdepolarizations in intact rat ventricular muscle.
Journal of cardiovascular pharmacology 2009;53(6):517-22.
2009: Fukui Shigefumi; Fukumoto Yoshihiro; Suzuki Jun; Saji Kenya; Nawata Jun; Shinozaki Tsuyoshi; Kagaya Yutaka; Watanabe Jun; Shimokawa Hiroaki
Diabetes mellitus accelerates left ventricular diastolic dysfunction through activation of the renin-angiotensin system in hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2009;32(6):472-80.
2009: Takagi Yusuke; Yasuda Satoshi; Takahashi Jun; Takeda Morihiko; Nakayama Masaharu; Ito Kenta; Hirose Masanori; Wakayama Yuji; Fukuda Koji; Shimokawa Hiroaki
Importance of dual induction tests for coronary vasospasm and ventricular fibrillation in patients surviving out-of-hospital cardiac arrest.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(4):767-9.
2009: Rashid Mamunur; Tawara Shunsuke; Fukumoto Yoshihiro; Seto Minoru; Yano Kazuo; Shimokawa Hiroaki
Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.
Circulation journal : official journal of the Japanese Circulation Society 2009;73(2):361-70.
2009: Arita Ryoichi; Hata Yasuaki; Nakao Shintaro; Kita Takeshi; Miura Muneki; Kawahara Shuhei; Zandi Souska; Almulki Lama; Tayyari Faryan; Shimokawa Hiroaki; Hafezi-Moghadam Ali; Ishibashi Tatsuro
Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.
Diabetes 2009;58(1):215-26.
2008: Tada Tomohiro; Nawata Jun; Wang Huan; Onoue Noriko; Zhulanqiqige Doe; Ito Kenta; Sugimura Koichiro; Fukumoto Yoshihiro; Shimokawa Hiroaki
Enhanced pulsatile pressure accelerates vascular smooth muscle migration: implications for atherogenesis of hypertension.
Cardiovascular research 2008;80(3):346-53.
2008: Fukumoto Yoshihiro; Shimokawa Hiroaki
[The role of Rho-kinase pathway on PAH]
Nippon rinsho. Japanese journal of clinical medicine 2008;66(11):2091-6.
2008: Kita Takeshi; Hata Yasuaki; Arita Ryoichi; Kawahara Shuhei; Miura Muneki; Nakao Shintaro; Mochizuki Yasutaka; Enaida Hiroshi; Goto Yoshinobu; Shimokawa Hiroaki; Hafezi-Moghadam Ali; Ishibashi Tatsuro
Role of TGF-beta in proliferative vitreoretinal diseases and ROCK as a therapeutic target.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(45):17504-9.
2008: Ito Kenta; Shimokawa Hiroaki
[Extracorporeal cardiac shock wave therapy for angina pectoris]
Nippon rinsho. Japanese journal of clinical medicine 2008;66(10):2019-26.
2008: Shimokawa Hiroaki; Yasuda Satoshi
Myocardial ischemia: Current concepts and future perspectives.
Journal of cardiology 2008;52(2):67-78.
2008: Takaki Aya; Morikawa Keiko; Tsutsui Masato; Murayama Yoshinori; Tekes Ender; Yamagishi Hiroto; Ohashi Junko; Yada Toyotaka; Yanagihara Nobuyuki; Shimokawa Hiroaki
Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice.
The Journal of experimental medicine 2008;205(9):2053-63.
2008: Yamaguchi Nobuhiro; Kumagai Koji; Fukuda Koji; Wakayama Yuji; Sugai Yoshinao; Hirose Masanori; Shimokawa Hiroaki
Electrophysiological properties of the right atrial septum in patients with atrial tachyarrhythmias.
The Tohoku journal of experimental medicine 2008;215(1):13-22.
2008: Kumagai Koji; Fukuda Koji; Wakayama Yuji; Sugai Yoshinao; Hirose Masanori; Yamaguchi Nobuhiro; Takase Kei; Yamauchi Yasuteru; Takahashi Atsushi; Aonuma Kazutaka; Shimokawa Hiroaki
Electrocardiographic characteristics of the variants of idiopathic left ventricular outflow tract ventricular tachyarrhythmias.
Journal of cardiovascular electrophysiology 2008;19(5):495-501.
2008: Fukui Shigefumi; Fukumoto Yoshihiro; Suzuki Jun; Saji Kenya; Nawata Jun; Tawara Shunsuke; Shinozaki Tsuyoshi; Kagaya Yutaka; Shimokawa Hiroaki
Long-term inhibition of Rho-kinase ameliorates diastolic heart failure in hypertensive rats.
Journal of cardiovascular pharmacology 2008;51(3):317-26.
2008: Fukumoto Yoshihiro; Yasuda Satoshi; Ito Akira; Shimokawa Hiroaki
Prognostic effects of benidipine in patients with vasospastic angina: comparison with diltiazem and amlodipine.
Journal of cardiovascular pharmacology 2008;51(3):253-7.
2008: Ikuta Kenjiro; Mori Takeshi; Yamamoto Tatsurhiro; Niidome Takuro; Shimokawa Hiroaki; Katayama Yoshiki
Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction.
Bioorganic & medicinal chemistry 2008;16(6):2811-8.
2008: Anegawa Go; Kawanaka Hirofumi; Yoshida Daisuke; Konishi Kozo; Yamaguchi Shohei; Kinjo Nao; Taketomi Akinobu; Hashizume Makoto; Shimokawa Hiroaki; Maehara Yoshihiko
Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2008;47(3):966-77.
2008: Oi Keiji; Fukumoto Yoshihiro; Ito Kenta; Uwatoku Toyokazu; Abe Kohtaro; Hizume Takatoshi; Shimokawa Hiroaki
Extracorporeal shock wave therapy ameliorates hindlimb ischemia in rabbits.
The Tohoku journal of experimental medicine 2008;214(2):151-8.
2008: Shiba Nobuyuki; Matsuki Mika; Takahashi Jun; Tada Tomohiro; Watanabe Jun; Shimokawa Hiroaki
Prognostic importance of chronic kidney disease in Japanese patients with chronic heart failure.
Circulation journal : official journal of the Japanese Circulation Society 2008;72(2):173-8.
2008: Kishi Takuya; Hirooka Yoshitaka; Shimokawa Hiroaki; Takeshita Akira; Sunagawa Kenji
Atorvastatin reduces oxidative stress in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2008;30(1):3-11.
2008: Onoue Noriko; Nawata Jun; Tada Tomohiro; Zhulanqiqige Doe; Wang Huan; Sugimura Koichiro; Fukumoto Yoshihiro; Shirato Kunio; Shimokawa Hiroaki
Increased static pressure promotes migration of vascular smooth muscle cells: involvement of the Rho-kinase pathway.
Journal of cardiovascular pharmacology 2008;51(1):55-61.
2008: Yasuda Satoshi; Ikuta Kenjiro; Uwatoku Toyokazu; Oi Keiji; Abe Kohtaro; Hyodo Fuminori; Yoshimitsu Kengo; Sugimura Kohtaro; Utsumi Hideo; Katayama Yoshiki; Shimokawa Hiroaki
In vivo magnetic resonance imaging of atherosclerotic lesions with a newly developed Evans blue-DTPA-gadolinium contrast medium in apolipoprotein-E-deficient mice.
Journal of vascular research 2008;45(2):123-8.
2007: Shiotani S; Shimada M; Taketomi A; Soejima Y; Yoshizumi T; Hashimoto K; Shimokawa H; Maehara Y
Rho-kinase as a novel gene therapeutic target in treatment of cold ischemia/reperfusion-induced acute lethal liver injury: effect on hepatocellular NADPH oxidase system.
Gene therapy 2007;14(19):1425-33.
2007: Uwatoku Toyokazu; Ito Kenta; Abe Kohtaro; Oi Keiji; Hizume Takatoshi; Sunagawa Kenji; Shimokawa Hiroaki
Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs.
Coronary artery disease 2007;18(5):397-404.
2007: Fukumoto Yoshihiro; Mohri Masahiro; Inokuchi Kosuke; Ito Akira; Hirakawa Yoji; Masumoto Akihiro; Hirooka Yoshitaka; Takeshita Akira; Shimokawa Hiroaki
Anti-ischemic effects of fasudil, a specific Rho-kinase inhibitor, in patients with stable effort angina.
Journal of cardiovascular pharmacology 2007;49(3):117-21.
2007: Jiang Bao Hua; Tawara Shunsuke; Abe Kohtaro; Takaki Aya; Fukumoto Yoshihiro; Shimokawa Hiroaki
Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats.
Journal of cardiovascular pharmacology 2007;49(2):85-9.
2007: Kita Takeshi; Hata Yasuaki; Kano Kumiko; Miura Muneki; Nakao Shintaro; Noda Yoshihiro; Shimokawa Hiroaki; Ishibashi Tatsuro
Transforming growth factor-beta2 and connective tissue growth factor in proliferative vitreoretinal diseases: possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitor.
Diabetes 2007;56(1):231-8.
2006: Abe Kohtaro; Tawara Shunsuke; Oi Keiji; Hizume Takatoshi; Uwatoku Toyokazu; Fukumoto Yoshihiro; Kaibuchi Kozo; Shimokawa Hiroaki
Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice.
Journal of cardiovascular pharmacology 2006;48(6):280-5.
2006: Sun Xiaojia; Minohara Motozumi; Kikuchi Hitoshi; Ishizu Takaaki; Tanaka Masahito; Piao Hua; Osoegawa Manabu; Ohyagi Yasumasa; Shimokawa Hiroaki; Kira Jun-Ichi
The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 2006;180(1-2):126-34.
2006: Hizume Takatoshi; Morikawa Keiko; Takaki Aya; Abe Kohtaro; Sunagawa Kenji; Amano Mutsuki; Kaibuchi Kozo; Kubo Chiharu; Shimokawa Hiroaki
Sustained elevation of serum cortisol level causes sensitization of coronary vasoconstricting responses in pigs in vivo: a possible link between stress and coronary vasospasm.
Circulation research 2006;99(7):767-75.
2006: Yamada Michiko; Tatsumi Ryuichi; Kikuiri Takashi; Okamoto Shinpei; Nonoshita Shinsuke; Mizunoya Wataru; Ikeuchi Yoshihide; Shimokawa Hiroaki; Sunagawa Kenji; Allen Ronald E
Matrix metalloproteinases are involved in mechanical stretch-induced activation of skeletal muscle satellite cells.
Muscle & nerve 2006;34(3):313-9.
2006: Furuyama Tadashi; Komori Kimihiro; Shimokawa Hiroaki; Matsumoto Yasuharu; Uwatoku Toyokazu; Hirano Katsuya; Maehara Yoshihiko
Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits.
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 2006;43(6):1249-56.
2006: Miura Muneki; Hata Yasuaki; Hirayama Kumiko; Kita Takeshi; Noda Yoshihiro; Fujisawa Kimihiko; Shimokawa Hiroaki; Ishibashi Tatsuro
Critical role of the Rho-kinase pathway in TGF-beta2-dependent collagen gel contraction by retinal pigment epithelial cells.
Experimental eye research 2006;82(5):849-59.
2006: Fukumoto Yoshihiro; Ito Akira; Uwatoku Toyokazu; Matoba Tetsuya; Kishi Takuya; Tanaka Haruki; Takeshita Akira; Sunagawa Kenji; Shimokawa Hiroaki
Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease.
Coronary artery disease 2006;17(1):63-70.
2006: Tatsumi Ryuichi; Yamada Michiko; Katsuki Yoshitaka; Okamoto Shinpei; Ishizaki Junji; Mizunoya Wataru; Ikeuchi Yoshihide; Hattori Akihito; Shimokawa Hiroaki; Allen Ronald E
Low-pH preparation of skeletal muscle satellite cells can be used to study activation in vitro.
The international journal of biochemistry & cell biology 2006;38(10):1678-85.
2005: Sun Hongtao; Fukumoto Yoshihiro; Ito Akira; Shimokawa Hiroaki; Sunagawa Kenji
Coronary microvascular dysfunction in patients with microvascular angina: analysis by TIMI frame count.
Journal of cardiovascular pharmacology 2005;46(5):622-6.
2005: Shimokawa Hiroaki; Morikawa Keiko
Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in animals and humans.
Journal of molecular and cellular cardiology 2005;39(5):725-32.
2005: Shimokawa Hiroaki; Takeshita Akira
Rho-kinase is an important therapeutic target in cardiovascular medicine.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(9):1767-75.
2005: Ito Koji; Hirooka Yoshitaka; Hori Nobuaki; Kimura Yoshikuni; Sagara Yoji; Shimokawa Hiroaki; Takeshita Akira; Sunagawa Kenji
Inhibition of rho-kinase in the nucleus tractus solitarius enhances glutamate sensitivity in rats.
Hypertension 2005;46(2):360-5.
2005: Eto Yasuhiro; Shimokawa Hiroaki; Fukumoto Yoshihiro; Matsumoto Yasuharu; Morishige Kunio; Kunihiro Ikuko; Kandabashi Tadashi; Takeshita Akira
Combination therapy with cerivastatin and nifedipine improves endothelial dysfunction after balloon injury in porcine coronary arteries.
Journal of cardiovascular pharmacology 2005;46(1):1-6.
2005: Kishi Takuya; Hirooka Yoshitaka; Masumoto Akihiro; Ito Koji; Kimura Yoshikuni; Inokuchi Kosuke; Tagawa Tatsuya; Shimokawa Hiroaki; Takeshita Akira; Sunagawa Kenji
Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure.
Circulation 2005;111(21):2741-7.
2005: Morikawa Keiko; Matoba Tetsuya; Kubota Hiroshi; Hatanaka Makoto; Fujiki Takako; Takahashi Shosuke; Takeshita Akira; Shimokawa Hiroaki
Influence of diabetes mellitus, hypercholesterolemia, and their combination on EDHF-mediated responses in mice.
Journal of cardiovascular pharmacology 2005;45(5):485-90.
2005: Zhao Yingjun; Fukumoto Yoshihiro; Mohri Masahiro; Shimokawa Hiroaki; Takeshita Akira
Impact of sex and age on coronary basal tone.
Internal medicine (Tokyo, Japan) 2005;44(4):354-5.
2005: Fujiki Takako; Shimokawa Hiroaki; Morikawa Keiko; Kubota Hiroshi; Hatanaka Makoto; Talukder M A Hassan; Matoba Tetsuya; Takeshita Akira; Sunagawa Kenji
Endothelium-derived hydrogen peroxide accounts for the enhancing effect of an angiotensin-converting enzyme inhibitor on endothelium-derived hyperpolarizing factor-mediated responses in mice.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(4):766-71.
2005: Hirooka Yoshitaka; Shimokawa Hiroaki
[Perspective of sympathetic nervous system inhibitors]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 3():565-72.
2005: Ito Koji; Hirooka Yoshitaka; Kimura Yoshikuni; Shimokawa Hiroaki; Takeshita Akira
Effects of hydroxyfasudil administered to the nucleus tractus solitarii on blood pressure and heart rate in spontaneously hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2005;27(2-3):269-77.
2005: Abe Kohtaro; Morikawa Keiko; Hizume Takatoshi; Uwatoku Toyokazu; Oi Keiji; Seto Minoru; Ikegaki Ichiro; Asano Toshio; Kaibuchi Kozo; Shimokawa Hiroaki
Prostacyclin does not inhibit rho-kinase: an implication for the treatment of pulmonary hypertension.
Journal of cardiovascular pharmacology 2005;45(2):120-4.
2005: Kimura Yoshikuni; Hirooka Yoshitaka; Sagara Yoji; Ito Koji; Kishi Takuya; Shimokawa Hiroaki; Takeshita Akira; Sunagawa Kenji
Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress.
Circulation research 2005;96(2):252-60.
2005: Hiroki Junko; Shimokawa Hiroaki; Mukai Yasushi; Ichiki Toshihiro; Takeshita Akira
Divergent effects of estrogen and nicotine on Rho-kinase expression in human coronary vascular smooth muscle cells.
Biochemical and biophysical research communications 2005;326(1):154-9.
2005: Hirooka Yoshitaka; Shimokawa Hiroaki
Therapeutic potential of rho-kinase inhibitors in cardiovascular diseases.
American journal of cardiovascular drugs : drugs, devices, and other interventions 2005;5(1):31-9.
2004: Nishida Takahiro; Shimokawa Hiroaki; Oi Keiji; Tatewaki Hideki; Uwatoku Toyokazu; Abe Kohtaro; Matsumoto Yasuharu; Kajihara Noriyoshi; Eto Masataka; Matsuda Takehisa; Yasui Hisataka; Takeshita Akira; Sunagawa Kenji
Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in vivo.
Circulation 2004;110(19):3055-61.
2004: Talukder M A Hassan; Fujiki Takako; Morikawa Keiko; Motoishi Minako; Matsuo Yoko; Hatanaka Makoto; Tsutsui Masato; Takeshita Akira; Shimokawa Hiroaki
Endothelial nitric oxide synthase-independent effects of an ACE inhibitor on coronary flow response to bradykinin in aged mice.
Journal of cardiovascular pharmacology 2004;44(5):557-63.
2004: Morikawa Keiko; Fujiki Takako; Matoba Tetsuya; Kubota Hiroshi; Hatanaka Makoto; Takahashi Shosuke; Shimokawa Hiroaki
Important role of superoxide dismutase in EDHF-mediated responses of human mesenteric arteries.
Journal of cardiovascular pharmacology 2004;44(5):552-6.
2004: Hirayama Kumiko; Hata Yasuaki; Noda Yoshihiro; Miura Muneki; Yamanaka Ichiro; Shimokawa Hiroaki; Ishibashi Tatsuro
The involvement of the rho-kinase pathway and its regulation in cytokine-induced collagen gel contraction by hyalocytes.
Investigative ophthalmology & visual science 2004;45(11):3896-903.
2004: Shimokawa Hiroaki
[Development of next generation of non-invasive medicine]
Fukuoka igaku zasshi = Hukuoka acta medica 2004;95(10):265-8.
2004: Hirooka Yoshitaka; Shimokawa Hiroaki; Takeshita Akira
Rho-kinase, a potential therapeutic target for the treatment of hypertension.
Drug news & perspectives 2004;17(8):523-7.
2004: Hiroki Junko; Fukumoto Yoshihiro; Shimokawa Hiroaki; Hirooka Yoshitaka; Takeshita Akira
[Inhibition of Rho-kinase by fasudil preventing anginal attacks associated with spastic angina: a case report]
Journal of cardiology 2004;44(4):161-4.
2004: Ito Akira; Fukumoto Yoshihiro; Shimokawa Hiroaki
Changing characteristics of patients with vasospastic angina in the era of new calcium channel blockers.
Journal of cardiovascular pharmacology 2004;44(4):480-5.
2004: Talukder M A Hassan; Fujiki Takako; Morikawa Keiko; Motoishi Minako; Kubota Hiroshi; Morishita Tsuyoshi; Tsutsui Masato; Takeshita Akira; Shimokawa Hiroaki
Up-regulated neuronal nitric oxide synthase compensates coronary flow response to bradykinin in endothelial nitric oxide synthase-deficient mice.
Journal of cardiovascular pharmacology 2004;44(4):437-45.
2004: Ito Koji; Hirooka Yoshitaka; Sagara Yoji; Kimura Yoshikuni; Kaibuchi Kozo; Shimokawa Hiroaki; Takeshita Akira; Sunagawa Kenji
Inhibition of Rho-kinase in the brainstem augments baroreflex control of heart rate in rats.
Hypertension 2004;44(4):478-83.
2004: Inokuchi Kousuke; Ito Akira; Fukumoto Yoshihiro; Matoba Tetsuya; Shiose Akira; Nishida Takahiro; Masuda Munetaka; Morita Shigeki; Shimokawa Hiroaki
Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery.
Journal of cardiovascular pharmacology 2004;44(3):275-7.
2004: Shiotani Satoko; Shimada Mitsuo; Suehiro Taketoshi; Soejima Yuji; Yosizumi Tomoharu; Shimokawa Hiroaki; Maehara Yoshihiko
Involvement of Rho-kinase in cold ischemia-reperfusion injury after liver transplantation in rats.
Transplantation 2004;78(3):375-82.
2004: Hiroki Junko; Shimokawa Hiroaki; Higashi Midoriko; Morikawa Keiko; Kandabashi Tadashi; Kawamura Natsumi; Kubota Toru; Ichiki Toshihiro; Amano Mutsuki; Kaibuchi Kozo; Takeshita Akira
Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells.
Journal of molecular and cellular cardiology 2004;37(2):537-46.
2004: Oi Keiji; Shimokawa Hiroaki; Hirakawa Yoji; Tashiro Hideki; Nakaike Ryuichi; Kozai Toshiyuki; Ohzono Keizaburo; Yamamoto Kunihiko; Koyanagi Samon; Okamatsu Shuichi; Tajimi Tsukasa; Kikuchi Yutaka; Takeshita Akira
Postprandial increase in plasma concentrations of remnant-like particles: an independent risk factor for restenosis after percutaneous coronary intervention.
Journal of cardiovascular pharmacology 2004;44(1):66-73.
2004: Yamamoto Tatsuhiro; Ikuta Kenjiro; Oi Keiji; Abe Kohtaro; Uwatoku Toyokazu; Hyodo Fuminori; Murata Masaharu; Shigetani Noboru; Yoshimitsu Kengo; Shimokawa Hiroaki; Utsumi Hideo; Katayama Yoshiki
In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent.
Bioorganic & medicinal chemistry letters 2004;14(11):2787-90.
2004: Shimokawa Hiroaki; Matoba Tetsuya
Hydrogen peroxide as an endothelium-derived hyperpolarizing factor.
Pharmacological research : the official journal of the Italian Pharmacological Society 2004;49(6):543-9.
2004: Kishi Takuya; Hirooka Yoshitaka; Kimura Yoshikuni; Ito Koji; Shimokawa Hiroaki; Takeshita Akira
Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats.
Circulation 2004;109(19):2357-62.
2004: Hattori Tsuyoshi; Shimokawa Hiroaki; Higashi Midoriko; Hiroki Junko; Mukai Yasushi; Tsutsui Hiroyuki; Kaibuchi Kozo; Takeshita Akira
Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice.
Circulation 2004;109(18):2234-9.
2004: Oi Keiji; Shimokawa Hiroaki; Hiroki Junko; Uwatoku Toyokazu; Abe Kohtaro; Matsumoto Yasuharu; Nakajima Yasuhiro; Nakajima Katsuyuki; Takeichi Sanae; Takeshita Akira
Remnant lipoproteins from patients with sudden cardiac death enhance coronary vasospastic activity through upregulation of Rho-kinase.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(5):918-22.
2004: Ito Koji; Hirooka Yoshitaka; Kishi Takuya; Kimura Yoshikuni; Kaibuchi Kozo; Shimokawa Hiroaki; Takeshita Akira
Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition.
Hypertension 2004;43(2):156-62.
2004: Abe Kohtaro; Shimokawa Hiroaki; Morikawa Keiko; Uwatoku Toyokazu; Oi Keiji; Matsumoto Yasuharu; Hattori Tsuyoshi; Nakashima Yutaka; Kaibuchi Kozo; Sueishi Katsuo; Takeshit Akira
Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.
Circulation research 2004;94(3):385-93.
2004: Yamamoto Tatsuhiro; Ikuta Kenjiro; Oi Keiji; Abe Kohtaro; Uwatoku Toyokazu; Murata Masaharu; Shigetani Noboru; Yoshimitsu Kengo; Shimokawa Hiroaki; Katayama Yoshiki
First functionalized MRI contrast agent recognizing vascular lesions.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2004;20(1):5-7.
2004: Hattori Tsuyoshi; Shimokawa Hiroaki; Higashi Midoriko; Hiroki Junko; Mukai Yasushi; Kaibuchi Kozo; Takeshita Akira
Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice.
Circulation research 2004;94(1):46-52.
2004: Matsumoto Yasuharu; Uwatoku Toyokazu; Oi Keiji; Abe Kohtaro; Hattori Tsuyoshi; Morishige Kunio; Eto Yasuhiro; Fukumoto Yoshihiro; Nakamura Kei-ichiro; Shibata Yosaburo; Matsuda Takehisa; Takeshita Akira; Shimokawa Hiroaki
Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(1):181-6.
2003: Morikawa Keiko; Shimokawa Hiroaki; Matoba Tetsuya; Kubota Hiroshi; Akaike Takaaki; Talukder M A Hassan; Hatanaka Makoto; Fujiki Takako; Maeda Hiroshi; Takahashi Shosuke; Takeshita Akira
Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization.
The Journal of clinical investigation 2003;112(12):1871-9.
2003: Kandabashi Tadashi; Shimokawa Hiroaki; Miyata Kenji; Kunihiro Ikuko; Eto Yasuhiro; Morishige Kunio; Matsumoto Yasuharu; Obara Kazuo; Nakayama Koichi; Takahashi Shosuke; Takeshita Akira
Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(12):2209-14.
2003: Inokuchi Kosuke; Hirooka Yoshitaka; Shimokawa Hiroaki; Sakai Koji; Kishi Takuya; Ito Koji; Kimura Yoshikuni; Takeshita Akira
Role of endothelium-derived hyperpolarizing factor in human forearm circulation.
Hypertension 2003;42(5):919-24.
2003: Higashi Midoriko; Shimokawa Hiroaki; Hattori Tsuyoshi; Hiroki Junko; Mukai Yasushi; Morikawa Keiko; Ichiki Toshihiro; Takahashi Shosuke; Takeshita Akira
Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system.
Circulation research 2003;93(8):767-75.
2003: Tokunou Tomotake; Shibata Rei; Kai Hisashi; Ichiki Toshihiro; Morisaki Takashi; Fukuyama Kae; Ono Hiroki; Iino Naoko; Masuda Satoko; Shimokawa Hiroaki; Egashira Kensuke; Imaizumi Tsutomu; Takeshita Akira
Apoptosis induced by inhibition of cyclic AMP response element-binding protein in vascular smooth muscle cells.
Circulation 2003;108(10):1246-52.
2003: Mukai Yasushi; Shimokawa Hiroaki; Matoba Tetsuya; Hiroki Junko; Kunihiro Ikuko; Fujiki Takako; Takeshita Akira
Acute vasodilator effects of HMG-CoA reductase inhibitors: involvement of PI3-kinase/Akt pathway and Kv channels.
Journal of cardiovascular pharmacology 2003;42(1):118-24.
2003: Matoba Tetsuya; Shimokawa Hiroaki; Morikawa Keiko; Kubota Hiroshi; Kunihiro Ikuko; Urakami-Harasawa Lemmy; Mukai Yasushi; Hirakawa Yoji; Akaike Takaaki; Takeshita Akira
Electron spin resonance detection of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in porcine coronary microvessels.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(7):1224-30.
2003: Shoji Tetsuya; Yonemitsu Yoshikazu; Komori Kimihiro; Tanii Mitsugu; Itoh Hiroyuki; Sata Shihoko; Shimokawa Hiroaki; Hasegawa Mamoru; Sueishi Katsuo; Maehara Yoshihiko
Intramuscular gene transfer of FGF-2 attenuates endothelial dysfunction and inhibits intimal hyperplasia of vein grafts in poor-runoff limbs of rabbit.
American journal of physiology. Heart and circulatory physiology 2003;285(1):H173-82.
2003: Ito Koji; Hirooka Yoshitaka; Sakai Koji; Kishi Takuya; Kaibuchi Kozo; Shimokawa Hiroaki; Takeshita Akira
Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system: possible involvement in neural mechanisms of hypertension.
Circulation research 2003;92(12):1337-43.
2003: Shirota Toshihiko; Yasui Hisataka; Shimokawa Hiroaki; Matsuda Takehisa
Fabrication of endothelial progenitor cell (EPC)-seeded intravascular stent devices and in vitro endothelialization on hybrid vascular tissue.
Biomaterials 2003;24(13):2295-302.
2003: Matoba Tetsuya; Shimokawa Hiroaki
Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in animals and humans.
Journal of pharmacological sciences 2003;92(1):1-6.
2003: Mohri Masahiro; Shimokawa Hiroaki
[Rho-kinase inhibitors for ischemic heart disease]
Nippon rinsho. Japanese journal of clinical medicine 2003;61 Suppl 5():874-9.
2003: Hirooka Yoshitaka; Sakai Koji; Kishi Takuya; Ito Koji; Shimokawa Hiroaki; Takeshita Akira
Enhanced depressor response to endothelial nitric oxide synthase gene transfer into the nucleus tractus solitarii of spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26(4):325-31.
2003: Uwatoku Toyokazu; Shimokawa Hiroaki; Abe Kohtaro; Matsumoto Yasuharu; Hattori Tsuyoshi; Oi Keiji; Matsuda Takehisa; Kataoka Kazunori; Takeshita Akira
Application of nanoparticle technology for the prevention of restenosis after balloon injury in rats.
Circulation research 2003;92(7):e62-9.
2003: Fukuyama Kae; Ichiki Toshihiro; Takeda Kotaro; Tokunou Tomotake; Iino Naoko; Masuda Satoko; Ishibashi Minako; Egashira Kensuke; Shimokawa Hiroaki; Hirano Katsuya; Kanaide Hideo; Takeshita Akira
Downregulation of vascular angiotensin II type 1 receptor by thyroid hormone.
Hypertension 2003;41(3):598-603.
2003: Shimokawa Hiroaki; Eto Yasuhiro; Miyata Kenji; Morishige Kunio; Kandabashi Tadashi; Matsushima Kouji; Takeshita Akira
Propagermanium suppresses macrophage-mediated formation of coronary arteriosclerotic lesions in pigs in vivo.
Journal of cardiovascular pharmacology 2003;41(3):372-80.
2003: Tanaka Eriko; Shimokawa Hiroaki; Kamiuneten Hitoshi; Eto Yasuhiro; Matsumoto Yasuharu; Morishige Kunio; Koike George; Yoshinaga Masaru; Egashira Kensuke; Tokunaga Osamu; Shiomi Masashi; Takeshita Akira
Disparity of MCP-1 mRNA and protein expressions between the carotid artery and the aorta in WHHL rabbits: one aspect involved in the regional difference in atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(2):244-50.
2003: Kishi Takuya; Hirooka Yoshitaka; Kimura Yoshikuni; Sakai Koji; Ito Koji; Shimokawa Hiroaki; Takeshita Akira
Overexpression of eNOS in RVLM improves impaired baroreflex control of heart rate in SHRSP. Rostral ventrolateral medulla. Stroke-prone spontaneously hypertensive rats.
Hypertension 2003;41(2):255-60.
2003: Kishi Takuya; Hirooka Yoshitaka; Mukai Yasushi; Shimokawa Hiroaki; Takeshita Akira
Atorvastatin causes depressor and sympatho-inhibitory effects with upregulation of nitric oxide synthases in stroke-prone spontaneously hypertensive rats.
Journal of hypertension 2003;21(2):379-86.
2003: Morishige Kunio; Shimokawa Hiroaki; Matsumoto Yasuharu; Eto Yasuhiro; Uwatoku Toyokazu; Abe Kohtaro; Sueishi Katsuo; Takeshita Akira
Overexpression of matrix metalloproteinase-9 promotes intravascular thrombus formation in porcine coronary arteries in vivo.
Cardiovascular research 2003;57(2):572-85.
2003: Eto Yasuhiro; Shimokawa Hiroaki; Tanaka Eriko; Morishige Kunio; Fuchigami Masahiro; Ishiwata Yoshiro; Matsushima Kouji; Takeshita Akira
Long-term treatment with propagermanium suppresses atherosclerosis in WHHL rabbits.
Journal of cardiovascular pharmacology 2003;41(2):171-7.
2003: Machida Yoji; Kubota Toru; Kawamura Natsumi; Funakoshi Hajime; Ide Tomomi; Utsumi Hideo; Li Yun You; Feldman Arthur M; Tsutsui Hiroyuki; Shimokawa Hiroaki; Takeshita Akira
Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium.
American journal of physiology. Heart and circulatory physiology 2003;284(2):H449-55.
2003: Hirooka Yoshitaka; Kishi Takuya; Sakai Koji; Shimokawa Hiroaki; Takeshita Akira
Effect of overproduction of nitric oxide in the brain stem on the cardiovascular response in conscious rats.
Journal of cardiovascular pharmacology 2003;41 Suppl 1():S119-26.
2003: Mohri Masahiro; Shimokawa Hiroaki; Hirakawa Yoji; Masumoto Akihiro; Takeshita Akira
Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm.
Journal of the American College of Cardiology 2003;41(1):15-9.
2002: Tagawa Tatsuya; Hirooka Yoshitaka; Shimokawa Hiroaki; Hironaga Kiyoshi; Sakai Koji; Oyama Jun-ichi; Takeshita Akira
Long-term treatment with eicosapentaenoic acid improves exercise-induced vasodilation in patients with coronary artery disease.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(6):823-9.
2002: Shimokawa Hiroaki; Hiramori Katsuhiko; Iinuma Hiroyuki; Hosoda Saichi; Kishida Hiroshi; Osada Hirofumi; Katagiri Takashi; Yamauchi Kazunobu; Yui Yoshiki; Minamino Takazo; Nakashima Mitsuyoshi; Kato Kazuzo
Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study.
Journal of cardiovascular pharmacology 2002;40(5):751-61.
2002: Abe Kohtaro; Shimokawa Hiroaki; Kubota Toru; Nawa Yukifumi; Takeshita Akira
Myocarditis associated with visceral larva migrans due to Toxocara canis.
Internal medicine (Tokyo, Japan) 2002;41(9):706-8.
2002: Mukai Yasushi; Shimokawa Hiroaki; Higashi Midoriko; Morikawa Keiko; Matoba Tetsuya; Hiroki Junko; Kunihiro Ikuko; Talukder Hassan M A; Takeshita Akira
Inhibition of renin-angiotensin system ameliorates endothelial dysfunction associated with aging in rats.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(9):1445-50.
2002: Fukumoto Yoshihiro; Urabe Yoshitoshi; Kubo Toshihiko; Kaku Tohru; Egashira Kensuke; Shimokawa Hiroaki; Takeshita Akira
Augmented vasodilator response to L-arginine after coronary angioplasty may attenuate restenosis.
Heart and vessels 2002;16(5):171-4.
2002: Funakoshi Hajime; Kubota Toru; Machida Yoji; Kawamura Natsumi; Feldman Arthur M; Tsutsui Hiroyuki; Shimokawa Hiroaki; Takeshita Akira
Involvement of inducible nitric oxide synthase in cardiac dysfunction with tumor necrosis factor-alpha.
American journal of physiology. Heart and circulatory physiology 2002;282(6):H2159-66.
2002: Funakoshi Hajime; Kubota Toru; Kawamura Natsumi; Machida Yoji; Feldman Arthur M; Tsutsui Hiroyuki; Shimokawa Hiroaki; Takeshita Akira
Disruption of inducible nitric oxide synthase improves beta-adrenergic inotropic responsiveness but not the survival of mice with cytokine-induced cardiomyopathy.
Circulation research 2002;90(9):959-65.
2002: Masumoto Akihiro; Mohri Masahiro; Shimokawa Hiroaki; Urakami Lemmy; Usui Makoto; Takeshita Akira
Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina.
Circulation 2002;105(13):1545-7.
2002: Matsumoto Yasuharu; Shimokawa Hiroaki; Morishige Kunio; Eto Yasuhiro; Takeshita Akira
Reduction in neointimal formation with a stent coated with multiple layers of releasable heparin in porcine coronary arteries.
Journal of cardiovascular pharmacology 2002;39(4):513-22.
2002: Kubo-Inoue Mayuko; Egashira Kensuke; Usui Makoto; Takemoto Masao; Ohtani Kisho; Katoh Makoto; Shimokawa Hiroaki; Takeshita Akira
Long-term inhibition of nitric oxide synthesis increases arterial thrombogenecity in rat carotid artery.
American journal of physiology. Heart and circulatory physiology 2002;282(4):H1478-84.
2002: Sun Hongtao; Mohri Masahiro; Shimokawa Hiroaki; Usui Makoto; Urakami Lemmy; Takeshita Akira
Coronary microvascular spasm causes myocardial ischemia in patients with vasospastic angina.
Journal of the American College of Cardiology 2002;39(5):847-51.
2002: Setoguchi Soko; Hirooka Yoshitaka; Eshima Kenichi; Shimokawa Hiroaki; Takeshita Akira
Tetrahydrobiopterin improves impaired endothelium-dependent forearm vasodilation in patients with heart failure.
Journal of cardiovascular pharmacology 2002;39(3):363-8.
2002: Shimokawa Hiroaki
Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases.
Journal of cardiovascular pharmacology 2002;39(3):319-27.
2002: Kishi Takuya; Hirooka Yoshitaka; Ito Koji; Sakai Koji; Shimokawa Hiroaki; Takeshita Akira
Cardiovascular effects of overexpression of endothelial nitric oxide synthase in the rostral ventrolateral medulla in stroke-prone spontaneously hypertensive rats.
Hypertension 2002;39(2):264-8.
2002: Kataoka Chu; Egashira Kensuke; Inoue Shujiro; Takemoto Masao; Ni Weihua; Koyanagi Masamichi; Kitamoto Shiro; Usui Makoto; Kaibuchi Kozo; Shimokawa Hiroaki; Takeshita Akira
Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats.
Hypertension 2002;39(2):245-50.
2002: Kandabashi Tadashi; Shimokawa Hiroaki; Mukai Yasushi; Matoba Tetsuya; Kunihiro Ikuko; Morikawa Keiko; Ito Masaaki; Takahashi Shosuke; Kaibuchi Kozo; Takeshita Akira
Involvement of rho-kinase in agonists-induced contractions of arteriosclerotic human arteries.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(2):243-8.
2002: Matoba Tetsuya; Shimokawa Hiroaki; Kubota Hiroshi; Morikawa Keiko; Fujiki Takako; Kunihiro Ikuko; Mukai Yasushi; Hirakawa Yoji; Takeshita Akira
Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries.
Biochemical and biophysical research communications 2002;290(3):909-13.
2001: Morishige K; Shimokawa H; Eto Y; Hoshijima M; Kaibuchi K; Takeshita A
In vivo gene transfer of dominant-negative rho-kinase induces regression of coronary arteriosclerosis in pigs.
Annals of the New York Academy of Sciences 2001;947():407-11.
2001: Masumoto A; Hirooka Y; Shimokawa H; Hironaga K; Setoguchi S; Takeshita A
Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans.
Hypertension 2001;38(6):1307-10.
2001: Ichiki T; Takeda K; Tokunou T; Iino N; Egashira K; Shimokawa H; Hirano K; Kanaide H; Takeshita A
Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(12):1896-901.
2001: Nakamura R; Egashira K; Arimura K; Machida Y; Ide T; Tsutsui H; Shimokawa H; Takeshita A
Increased inactivation of nitric oxide is involved in impaired coronary flow reserve in heart failure.
American journal of physiology. Heart and circulatory physiology 2001;281(6):H2619-25.
2001: Oyama J; Shimokawa H; Morita S; Yasui H; Takeshita A
Elevated interleukin-1beta in pericardial fluid of patients with ischemic heart disease.
Coronary artery disease 2001;12(7):567-71.
2001: Tokunou T; Ichiki T; Takeda K; Funakoshi Y; Iino N; Shimokawa H; Egashira K; Takeshita A
Thrombin induces interleukin-6 expression through the cAMP response element in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(11):1759-63.
2001: Kishi T; Hirooka Y; Sakai K; Shigematsu H; Shimokawa H; Takeshita A
Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release.
Hypertension 2001;38(4):896-901.
2001: Ohnaka K; Shimoda S; Nawata H; Shimokawa H; Kaibuchi K; Iwamoto Y; Takayanagi R
Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts.
Biochemical and biophysical research communications 2001;287(2):337-42.
2001: Tada H; Egashira K; Yamamoto M; Usui M; Arai Y; Katsuda Y; Shimokawa H; Takeshita A
Role of nitric oxide in regulation of coronary blood flow in response to increased metabolic demand in dogs with pacing-induced heart failure.
Japanese circulation journal 2001;65(9):827-33.
2001: Setoguchi S; Mohri M; Shimokawa H; Takeshita A
Tetrahydrobiopterin improves endothelial dysfunction in coronary microcirculation in patients without epicardial coronary artery disease.
Journal of the American College of Cardiology 2001;38(2):493-8.
2001: Funakoshi Y; Ichiki T; Shimokawa H; Egashira K; Takeda K; Kaibuchi K; Takeya M; Yoshimura T; Takeshita A
Rho-kinase mediates angiotensin II-induced monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells.
Hypertension 2001;38(1):100-4.
2001: Shimokawa H; Morishige K; Miyata K; Kandabashi T; Eto Y; Ikegaki I; Asano T; Kaibuchi K; Takeshita A
Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo.
Cardiovascular research 2001;51(1):169-77.
2001: Takeda K; Ichiki T; Tokunou T; Iino N; Fujii S; Kitabatake A; Shimokawa H; Takeshita A
Critical role of Rho-kinase and MEK/ERK pathways for angiotensin II-induced plasminogen activator inhibitor type-1 gene expression.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(5):868-73.
2001: Morishige K; Shimokawa H; Eto Y; Kandabashi T; Miyata K; Matsumoto Y; Hoshijima M; Kaibuchi K; Takeshita A
Adenovirus-mediated transfer of dominant-negative rho-kinase induces a regression of coronary arteriosclerosis in pigs in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(4):548-54.
2001: Mukai Y; Shimokawa H; Matoba T; Kandabashi T; Satoh S; Hiroki J; Kaibuchi K; Takeshita A
Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(6):1062-4.
2001: Arimura K; Egashira K; Nakamura R; Ide T; Tsutsui H; Shimokawa H; Takeshita A
Increased inactivation of nitric oxide is involved in coronary endothelial dysfunction in heart failure.
American journal of physiology. Heart and circulatory physiology 2001;280(1):H68-75.
2001: Shimokawa H
Beneficial effects of eicosapentaenoic acid on endothelial vasodilator functions in animals and humans.
World review of nutrition and dietetics 2001;88():100-8.
2000: Matoba T; Shimokawa H; Nakashima M; Hirakawa Y; Mukai Y; Hirano K; Kanaide H; Takeshita A
Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice.
The Journal of clinical investigation 2000;106(12):1521-30.
2000: Sakai K; Hirooka Y; Matsuo I; Eshima K; Shigematsu H; Shimokawa H; Takeshita A
Overexpression of eNOS in NTS causes hypotension and bradycardia in vivo.
Hypertension 2000;36(6):1023-8.
2000: Yogo K; Shimokawa H; Funakoshi H; Kandabashi T; Miyata K; Okamoto S; Egashira K; Huang P; Akaike T; Takeshita A
Different vasculoprotective roles of NO synthase isoforms in vascular lesion formation in mice.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(11):E96-E100.
2000: Miyata K; Shimokawa H; Kandabashi T; Higo T; Morishige K; Eto Y; Egashira K; Kaibuchi K; Takeshita A
Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(11):2351-8.
2000: Koyanagi M; Egashira K; Kitamoto S; Ni W; Shimokawa H; Takeya M; Yoshimura T; Takeshita A
Role of monocyte chemoattractant protein-1 in cardiovascular remodeling induced by chronic blockade of nitric oxide synthesis.
Circulation 2000;102(18):2243-8.
2000: Yamamoto M; Egashira K; Arimura K; Tada H; Shimokawa H; Takeshita A
Coronary vascular K+ATP channels contribute to the maintenance of myocardial perfusion in dogs with pacing-induced heart failure.
Japanese circulation journal 2000;64(9):701-7.
2000: Kitamoto S; Egashira K; Kataoka C; Koyanagi M; Katoh M; Shimokawa H; Morishita R; Kaneda Y; Sueishi K; Takeshita A
Increased activity of nuclear factor-kappaB participates in cardiovascular remodeling induced by chronic inhibition of nitric oxide synthesis in rats.
Circulation 2000;102(7):806-12.
2000: Eto Y; Shimokawa H; Hiroki J; Morishige K; Kandabashi T; Matsumoto Y; Amano M; Hoshijima M; Kaibuchi K; Takeshita A
Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs.
American journal of physiology. Heart and circulatory physiology 2000;278(6):H1744-50.
2000: Kuga T; Shimokawa H; Hirakawa Y; Kadokami Y; Arai Y; Fukumoto Y; Kuwata K; Kozai T; Egashira K; Takeshita A
Increased expression of L-type calcium channels in vascular smooth muscle cells at spastic site in a porcine model of coronary artery spasm.
Journal of cardiovascular pharmacology 2000;35(5):822-8.
2000: Morishige K; Shimokawa H; Yamawaki T; Miyata K; Eto Y; Kandabashi T; Yogo K; Higo T; Egashira K; Ueno H; Takeshita A
Local adenovirus-mediated transfer of C-type natriuretic peptide suppresses vascular remodeling in porcine coronary arteries in vivo.
Journal of the American College of Cardiology 2000;35(4):1040-7.
2000: Kandabashi T; Shimokawa H; Miyata K; Kunihiro I; Kawano Y; Fukata Y; Higo T; Egashira K; Takahashi S; Kaibuchi K; Takeshita A
Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta.
Circulation 2000;101(11):1319-23.
2000: Miyata K; Shimokawa H; Higo T; Yamawaki T; Katsumata N; Kandabashi T; Tanaka E; Takamura Y; Yogo K; Egashira K; Takeshita A
Sarpogrelate, a selective 5-HT2A serotonergic receptor antagonist, inhibits serotonin-induced coronary artery spasm in a porcine model.
Journal of cardiovascular pharmacology 2000;35(2):294-301.
2000: Shimokawa H
Cellular and molecular mechanisms of coronary artery spasm: lessons from animal models.
Japanese circulation journal 2000;64(1):1-12.
2000: Usui M; Egashira K; Tomita H; Koyanagi M; Katoh M; Shimokawa H; Takeya M; Yoshimura T; Matsushima K; Takeshita A
Important role of local angiotensin II activity mediated via type 1 receptor in the pathogenesis of cardiovascular inflammatory changes induced by chronic blockade of nitric oxide synthesis in rats.
Circulation 2000;101(3):305-10.
2000: Koyanagi M; Egashira K; Kubo-Inoue M; Usui M; Kitamoto S; Tomita H; Shimokawa H; Takeshita A
Role of transforming growth factor-beta1 in cardiovascular inflammatory changes induced by chronic inhibition of nitric oxide synthesis.
Hypertension 2000;35(1 Pt 1):86-90.
1999: Usui M; Egashira K; Kitamoto S; Koyanagi M; Katoh M; Kataoka C; Shimokawa H; Takeshita A
Pathogenic role of oxidative stress in vascular angiotensin-converting enzyme activation in long-term blockade of nitric oxide synthesis in rats.
Hypertension 1999;34(4 Pt 1):546-51.
1999: Shimokawa H; Seto M; Katsumata N; Amano M; Kozai T; Yamawaki T; Kuwata K; Kandabashi T; Egashira K; Ikegaki I; Asano T; Kaibuchi K; Takeshita A
Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm.
Cardiovascular research 1999;43(4):1029-39.
1999: Miyata K; Shimokawa H; Yamawaki T; Kunihiro I; Zhou X; Higo T; Tanaka E; Katsumata N; Egashira K; Takeshita A
Endothelial vasodilator function is preserved at the spastic/inflammatory coronary lesions in pigs.
Circulation 1999;100(13):1432-7.
1999: Takamura Y; Shimokawa H; Zhao H; Igarashi H; Egashira K; Takeshita A
Important role of endothelium-derived hyperpolarizing factor in shear stress--induced endothelium-dependent relaxations in the rat mesenteric artery.
Journal of cardiovascular pharmacology 1999;34(3):381-7.
1999: Cheng X S; Shimokawa H; Momii H; Oyama J; Fukuyama N; Egashira K; Nakazawa H; Takeshita A
Role of superoxide anion in the pathogenesis of cytokine-induced myocardial dysfunction in dogs in vivo.
Cardiovascular research 1999;42(3):651-9.
1999: Tagawa H; Shimokawa H; Tagawa T; Kuroiwa-Matsumoto M; Hirooka Y; Takeshita A
Long-term treatment with eicosapentaenoic acid augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilatation in patients with coronary artery disease.
Journal of cardiovascular pharmacology 1999;33(4):633-40.
1999: Zhao H; Shimokawa H; Uragami-Harasawa L; Igarashi H; Takeshita A
Long-term vascular effects of Nomega-nitro-L-arginine methyl ester are not soley mediated by inhibition of endothelial nitric oxide synthesis in the rat mesenteric artery.
Journal of cardiovascular pharmacology 1999;33(4):554-66.
1999: Shimokawa H
Primary endothelial dysfunction: atherosclerosis.
Journal of molecular and cellular cardiology 1999;31(1):23-37.
1998: Momii H; Shimokawa H; Oyama J; Cheng X S; Nakamura R; Egashira K; Nakazawa H; Takeshita A
Inhibition of adhesion molecules markedly ameliorates cytokine-induced sustained myocardial dysfunction in dogs in vivo.
Journal of molecular and cellular cardiology 1998;30(12):2637-50.
1998: Shimokawa H; Kuroiwa-Matsumoto M; Takeshita A
Cytokine generation capacities of monocytes are reduced in patients with severe heart failure.
American heart journal 1998;136(6):991-1002.
1998: Katoh M; Egashira K; Usui M; Ichiki T; Tomita H; Shimokawa H; Rakugi H; Takeshita A
Cardiac angiotensin II receptors are upregulated by long-term inhibition of nitric oxide synthesis in rats.
Circulation research 1998;83(7):743-51.
1998: Tomita H; Egashira K; Kubo-Inoue M; Usui M; Koyanagi M; Shimokawa H; Takeya M; Yoshimura T; Takeshita A
Inhibition of NO synthesis induces inflammatory changes and monocyte chemoattractant protein-1 expression in rat hearts and vessels.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(9):1456-64.
1998: Yamawaki T; Shimokawa H; Kozai T; Miyata K; Higo T; Tanaka E; Egashira K; Shiraishi T; Tamai H; Igaki K; Takeshita A
Intramural delivery of a specific tyrosine kinase inhibitor with biodegradable stent suppresses the restenotic changes of the coronary artery in pigs in vivo.
Journal of the American College of Cardiology 1998;32(3):780-6.
1998: Tomita H; Egashira K; Ohara Y; Takemoto M; Koyanagi M; Katoh M; Yamamoto H; Tamaki K; Shimokawa H; Takeshita A
Early induction of transforming growth factor-beta via angiotensin II type 1 receptors contributes to cardiac fibrosis induced by long-term blockade of nitric oxide synthesis in rats.
Hypertension 1998;32(2):273-9.
1998: Oyama J i; Shimokawa H; Momii H; Cheng X; Fukuyama N; Arai Y; Egashira K; Nakazawa H; Takeshita A
Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo.
The Journal of clinical investigation 1998;101(10):2207-14.
1998: Mohri M; Koyanagi M; Egashira K; Tagawa H; Ichiki T; Shimokawa H; Takeshita A
Angina pectoris caused by coronary microvascular spasm.
Lancet 1998;351(9110):1165-9.
1997: Katsumata N; Shimokawa H; Seto M; Kozai T; Yamawaki T; Kuwata K; Egashira K; Ikegaki I; Asano T; Sasaki Y; Takeshita A
Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta.
Circulation 1997;96(12):4357-63.
1997: Mohri M; Egashira K; Kuga T; Shimokawa H; Takeshita A
Correlations between recruitable coronary collateral flow velocities, distal occlusion pressure, and electrocardiographic changes in patients undergoing angioplasty.
Japanese circulation journal 1997;61(12):971-8.
1997: Takemoto M; Egashira K; Tomita H; Usui M; Okamoto H; Kitabatake A; Shimokawa H; Sueishi K; Takeshita A
Chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade: effects on cardiovascular remodeling in rats induced by the long-term blockade of nitric oxide synthesis.
Hypertension 1997;30(6):1621-7.
1997: Urakami-Harasawa L; Shimokawa H; Nakashima M; Egashira K; Takeshita A
Importance of endothelium-derived hyperpolarizing factor in human arteries.
The Journal of clinical investigation 1997;100(11):2793-9.
1997: Fukumoto Y; Shimokawa H; Kozai T; Kadokami T; Kuwata K; Yonemitsu Y; Kuga T; Egashira K; Sueishi K; Takeshita A
Vasculoprotective role of inducible nitric oxide synthase at inflammatory coronary lesions induced by chronic treatment with interleukin-1beta in pigs in vivo.
Circulation 1997;96(9):3104-11.
1997: Alpaslan M; Shimokawa H; Kuroiwa-Matsumoto M; Harasawa Y; Takeshita A
Short-term estrogen administration ameliorates dobutamine-induced myocardial ischemia in postmenopausal women with coronary artery disease.
Journal of the American College of Cardiology 1997;30(6):1466-71.
1997: Tagawa H; Shimokawa H; Tagawa T; Kuroiwa-Matsumoto M; Hirooka Y; Takeshita A
Short-term estrogen augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilation in postmenopausal women.
Journal of cardiovascular pharmacology 1997;30(4):481-8.
1997: Tada H; Egashira K; Yamamoto M; Ueno H; Takemoto M; Shimokawa H; Takeshita A
Glibenclamide, a specific inhibitor of ATP-sensitive K+ channels, inhibits coronary vasodilation induced by angiotensin II-receptor antagonists.
Journal of cardiovascular pharmacology 1997;30(3):313-9.
1997: Kozai T; Shimokawa H; Yamawaki T; Fukumoto Y; Kadokami T; Kuwata K; Katsumata N; Egashira K; Takeshita A
Platelet activating factor causes hyperconstriction at the inflammatory coronary lesions in pigs in vivo.
Coronary artery disease 1997;8(7):423-32.
1997: Mohri M; Egashira K; Tagawa T; Kuga T; Tagawa H; Harasawa Y; Shimokawa H; Takeshita A
Basal release of nitric oxide is decreased in the coronary circulation in patients with heart failure.
Hypertension 1997;30(1 Pt 1):50-6.
1997: Kuga T; Mohri M; Egashira K; Hirakawa Y; Tagawa T; Shimokawa H; Takeshita A
Bradykinin-induced vasodilation of human coronary arteries in vivo: role of nitric oxide and angiotensin-converting enzyme.
Journal of the American College of Cardiology 1997;30(1):108-12.
1997: Tagawa T; Mohri M; Tagawa H; Egashira K; Shimokawa H; Kuga T; Hirooka Y; Takeshita A
Role of nitric oxide in substance P-induced vasodilation differs between the coronary and forearm circulation in humans.
Journal of cardiovascular pharmacology 1997;29(4):546-53.
1997: Kozai T; Shimokawa H; Fukumoto Y; Kobayashi S; Owada M K; Kadokami T; Ito A; Kuwata K; Egashira K; Shiraishi T; Kanaide H; Takeshita A
Tyrosine kinase inhibitor markedly suppresses the development of coronary lesions induced by long-term treatment with platelet-derived growth factor in pigs in vivo.
Journal of cardiovascular pharmacology 1997;29(4):536-45.
1997: Kuga T; Kadokami T; Kuwata K; Hata H; Ohara Y; Egashira K; Shimokawa H; Takeshita A
Central role of vascular smooth muscle hyperreactivity in coronary hyperconstriction after balloon injury in miniature pigs.
Coronary artery disease 1997;8(2):69-75.
1997: Fukumoto Y; Shimokawa H; Ito A; Kadokami T; Yonemitsu Y; Aikawa M; Owada M K; Egashira K; Sueishi K; Nagai R; Yazaki Y; Takeshita A
Inflammatory cytokines cause coronary arteriosclerosis-like changes and alterations in the smooth-muscle phenotypes in pigs.
Journal of cardiovascular pharmacology 1997;29(2):222-31.
1997: Takemoto M; Egashira K; Usui M; Numaguchi K; Tomita H; Tsutsui H; Shimokawa H; Sueishi K; Takeshita A
Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats.
The Journal of clinical investigation 1997;99(2):278-87.
1996: Fukumoto Y; Shimokawa H; Kozai T; Kadokami T; Kuwata K; Owada M K; Shiraishi T; Kuga T; Egashira K; Takeshita A
Tyrosine kinase inhibitor suppresses the (re) stenotic changes of the coronary artery after balloon injury in pigs.
Cardiovascular research 1996;32(6):1131-40.
1996: Fukumoto Y; Urabe Y; Shimokawa H; Chishaki-Suyama A; Takeshita A
Slowing of ventricular rate quickly improved ventricular dysfunction and exercise intolerance in patients with chronic atrial tachycardia.
Fukuoka igaku zasshi = Hukuoka acta medica 1996;87(12):274-7.
1996: Shimokawa H; Yasutake H; Fujii K; Owada M K; Nakaike R; Fukumoto Y; Takayanagi T; Nagao T; Egashira K; Fujishima M; Takeshita A
The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation.
Journal of cardiovascular pharmacology 1996;28(5):703-11.
1996: Ito A; Shimokawa H; Fukumoto Y; Kadokami T; Nakaike R; Takayanagi T; Egashira K; Sueishi K; Takeshita A
The role of fibroblast growth factor-2 in the vascular effects of interleukin-1 beta in porcine coronary arteries in vivo.
Cardiovascular research 1996;32(3):570-9.
1996: Kadokami T; Shimokawa H; Ito A; Mohri M; Takeshita A
Disappearance of coronary artery-ventricular fistulas after a radical operation for tetralogy of Fallot.
Japanese circulation journal 1996;60(8):624-7.
1996: Nakaike R; Shimokawa H; Owada M K; Tokunaga O; Yasutake H; Kishimoto T; Imada C; Shiraishi T; Egashira K; Takeshita A
Vanadate causes synthesis of endothelium-derived NO via pertussis toxin-sensitive G protein in pigs.
The American journal of physiology 1996;271(1 Pt 2):H296-302.
1996: Kadokami T; Shimokawa H; Fukumoto Y; Ito A; Takayanagi T; Egashira K; Takeshita A
Coronary artery spasm does not depend on the intracellular calcium store but is substantially mediated by the protein kinase C-mediated pathway in a swine model with interleukin-1 beta in vivo.
Circulation 1996;94(2):190-6.
1996: Kadokami T; Egashira K; Kuwata K; Fukumoto Y; Kozai T; Yasutake H; Kuga T; Shimokawa H; Sueishi K; Takeshita A
Altered serotonin receptor subtypes mediate coronary microvascular hyperreactivity in pigs with chronic inhibition of nitric oxide synthesis.
Circulation 1996;94(2):182-9.
1996: Katsuda Y; Egashira K; Ueno H; Arai Y; Akatsuka Y; Kuga T; Shimokawa H; Takeshita A
ATP-sensitive K+ channel opener pinacidil augments beta 1-adrenoceptor-induced coronary vasodilation in dogs.
The American journal of physiology 1996;270(6 Pt 2):H2210-5.
1996: Numaguchi K; Shimokawa H; Nakaike R; Egashira K; Takeshita A
PKC inhibitors prevent endothelial dysfunction after myocardial ischemia-reperfusion in rats.
The American journal of physiology 1996;270(5 Pt 2):H1634-9.
1996: Egashira K; Katsuda Y; Mohri M; Kuga T; Tagawa T; Shimokawa H; Takeshita A
Basal release of endothelium-derived nitric oxide at site of spasm in patients with variant angina.
Journal of the American College of Cardiology 1996;27(6):1444-9.
1996: Tsutsui M; Shimokawa H; Higuchi S; Yoshihara S; Hayashida K; Sobashima A; Kuga T; Matsuguchi T; Okamatsu S
Effect of cilostazol, a novel anti-platelet drug, on restenosis after percutaneous transluminal coronary angioplasty.
Japanese circulation journal 1996;60(4):207-15.
1996: Nakaike R; Urabe Y; Shimokawa H; Kinjoh M; Takeshita A
Recurrent myocardial infarction provoked by multiple giant coronary aneurysms. A case report.
Angiology 1996;47(3):311-4.
1996: Numaguchi K; Egashira K; Sakata M; Shimokawa H; Takeshita A
Coronary vascular ATP-sensitive potassium channels are activated to a greater extent in spontaneously hypertensive rats than in Wistar-Kyoto rats.
Journal of hypertension 1996;14(2):183-9.
1996: Shimokawa H; Tsutsui M; Mizuki T; Hase K; Kuwaoka I; Nogami N; Okamatsu S; Nakanishi K
Endothelial Gi protein expression is markedly low in human coronary microvessels.
Journal of cardiovascular pharmacology 1996;27(2):297-302.
1996: Shimokawa H; Ito A; Fukumoto Y; Kadokami T; Nakaike R; Sakata M; Takayanagi T; Egashira K; Takeshita A
Chronic treatment with interleukin-1 beta induces coronary intimal lesions and vasospastic responses in pigs in vivo. The role of platelet-derived growth factor.
The Journal of clinical investigation 1996;97(3):769-76.
1996: Tsutsui M; Shimokawa H; Tanaka S; Yoshihara S; Higuchi S; Matsuguchi T; Okamatsu S
Granulocyte activation in restenosis after percutaneous transluminal coronary angioplasty.
Japanese circulation journal 1996;60(1):27-34.
1995: Numaguchi K; Egashira K; Takemoto M; Kadokami T; Shimokawa H; Sueishi K; Takeshita A
Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats.
Hypertension 1995;26(6 Pt 1):957-62.
1995: Ito A; Egashira K; Kadokami T; Fukumoto Y; Takayanagi T; Nakaike R; Kuga T; Sueishi K; Shimokawa H; Takeshita A
Chronic inhibition of endothelium-derived nitric oxide synthesis causes coronary microvascular structural changes and hyperreactivity to serotonin in pigs.
Circulation 1995;92(9):2636-44.
1995: Shimokawa H; Takeshita A
Endothelium-dependent regulation of the cardiovascular system.
Internal medicine (Tokyo, Japan) 1995;34(10):939-46.
1995: Katsuda Y; Egashira K; Akatsuka Y; Narishige T; Shimokawa H; Takeshita A
Endothelium-derived nitric oxide does not modulate metabolic coronary vasodilation induced by tachycardia in dogs.
Journal of cardiovascular pharmacology 1995;26(3):437-44.
1995: Ito A; Shimokawa H; Kadokami T; Fukumoto Y; Owada M K; Shiraishi T; Nakaike R; Takayanagi T; Egashira K; Takeshita A
Tyrosine kinase inhibitor suppresses coronary arteriosclerotic changes and vasospastic responses induced by chronic treatment with interleukin-1 beta in pigs in vivo.
The Journal of clinical investigation 1995;96(3):1288-94.
1995: Katsuda Y; Egashira K; Ueno H; Akatsuka Y; Narishige T; Arai Y; Takayanagi T; Shimokawa H; Takeshita A
Glibenclamide, a selective inhibitor of ATP-sensitive K+ channels, attenuates metabolic coronary vasodilatation induced by pacing tachycardia in dogs.
Circulation 1995;92(3):511-7.
1995: Fukai T; Egashira K; Numaguchi K; Hata H; Takahashi T; Kasuya H; Sakata M; Shimokawa H; Takeshita A
Endothelin-1 is not involved in serotonin-induced coronary spasm in a swine model.
Cardiovascular research 1995;30(2):193-9.
1995: Kuga T; Egashira K; Mohri M; Tsutsui H; Harasawa Y; Urabe Y; Ando S; Shimokawa H; Takeshita A
Bradykinin-induced vasodilation is impaired at the atherosclerotic site but is preserved at the spastic site of human coronary arteries in vivo.
Circulation 1995;92(2):183-9.
1995: Nakaike R; Shimokawa H; Yasutake H; Sumimoto H; Ito A; Numaguchi K; Egashira K; Takeshige K; Takeshita A
Effects of L-arginine analogues on vasomotion of isolated porcine coronary arteries.
The American journal of physiology 1995;268(5 Pt 2):H1966-72.
1995: Kuga T; Ohara Y; Shimokawa H; Ibayashi S; Tomoike H; Takeshita A
Inhibitory effects of aspirin on coronary hyperreactivity to autacoids after arterial balloon injury in miniature pigs.
Journal of cardiovascular pharmacology 1995;25(2):273-81.
1995: Shimokawa H; Nakaike R; Takeshita A
Significance of defective endothelial signal transduction in impaired endothelium-dependent relaxation in atherosclerosis.
Gerontology 1995;41 Suppl 1():28-33.
1994: Ito A; Shimokawa H; Nakaike R; Fukai T; Sakata M; Takayanagi T; Egashira K; Takeshita A
Role of protein kinase C-mediated pathway in the pathogenesis of coronary artery spasm in a swine model.
Circulation 1994;90(5):2425-31.
1994: Onoyama Y; Shimokawa H; Sakai K; Honda N; Nakano H
Angiogenic activity of human villi and decidua in the first trimester of pregnancy.
Fukuoka igaku zasshi = Hukuoka acta medica 1994;85(10):287-93.
1994: Tsutsui M; Shimokawa H; Tanaka S; Kuwaoka I; Hase K; Nogami N; Nakanishi K; Okamatsu S
Endothelial Gi protein in human coronary arteries.
European heart journal 1994;15(9):1261-6.
1994: Akatsuka Y; Egashira K; Katsuda Y; Narishige T; Ueno H; Shimokawa H; Takeshita A
ATP sensitive potassium channels are involved in adenosine A2 receptor mediated coronary vasodilatation in the dog.
Cardiovascular research 1994;28(6):906-11.
1993: Tagawa H; Tomoike H; Mitsuoka W; Satoh S; Kuga T; Shimokawa H; Nakamura M; Takeshita A
Hyperreactivity of aortic smooth muscle to serotonin is related to the presence of atheroma in Watanabe heritable hyperlipidaemic rabbits.
Cardiovascular research 1993;27(12):2164-9.
1993: Tsutsui M; Shimokawa H; Yoshihara S; Sobashima A; Hayashida K; Higuchi S; Yamamoto K; Matsuguchi T; Okamatsu S
Intracellular magnesium deficiency in acute myocardial infarction.
Japanese heart journal 1993;34(4):391-401.
1993: Tashiro H; Shimokawa H; Koyanagi S; Takeshita A
Clinical characteristics of patients with spontaneous remission of variant angina.
Japanese circulation journal 1993;57(2):117-22.
1993: Shimokawa H
[Endothelial repair process and endothelium-dependent relaxation--endothelial signal transduction system and its abnormality]
Japanese circulation journal 1993;57 Suppl 4():1189-92.
1992: Tsutsui M; Matsuguchi T; Tsutsui H; Yoshida T; Yoshihara S; Yamamoto K; Hisanou R; Shimokawa H; Okamatsu S
Alcohol-induced sinus bradycardia and hypotension in patients with syncope.
Japanese heart journal 1992;33(6):875-9.
1990: Maeda H; Shimokawa H; Satoh S; Yamaguchi Y; Hisanaga S; Koyanagi T; Nakano H
Safety of cordocentesis under ultrasound guidance for fetal blood sampling.
Nippon Sanka Fujinka Gakkai zasshi 1990;42(2):199-202.
1989: Kashiwabara Y; Onoyama Y; Shimokawa H; Hisanaga S; Nakano H
A new method for measurement of surfactant specific apoprotein in amniotic fluid.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1989;29(2):147-52.
1989: Miyamoto S; Shimokawa H; Sumioki H; Nakano H
Physiologic role of endogenous human atrial natriuretic peptide in preeclamptic pregnancies.
American journal of obstetrics and gynecology 1989;160(1):155-9.
1989: Maeda H; Shimokawa H; Yamaguchi Y; Sueishi K; Nakano H
The influence of pleural effusion on pulmonary growth in the human fetus.
Journal of perinatal medicine 1989;17(3):231-6.
1988: Miyamoto S; Shimokawa H; Touno A; Kurokawa T; Nakano H
Characteristics of changes in blood circulation induced by cold stimulation in pre-eclamptic women.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1988;27(2):159-64.
1988: Maeda H; Shimokawa H; Satoh S; Nakano H; Nunoue T
Nonimmunologic hydrops fetalis resulting from intrauterine human parvovirus B-19 infection: report of two cases.
Obstetrics and gynecology 1988;72(3 Pt 2):482-5.
1988: Shimokawa H; Hara K; Fukuda A; Nakano H
Idiopathic hydrops fetalis successfully treated in utero.
Obstetrics and gynecology 1988;71(6 Pt 2):984-6.
1988: Miyamoto S; Shimokawa H; Kurokawa T; Nakano H
How does pre-eclampsia influence thermal conductivity of the skin?
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1988;26(3):361-5.
1988: Shimokawa H; Nagasawa K; Irie T; Egashira S; Egashira K; Sagara T; Kikuchi Y; Nakamura M
Clinical characteristics and long-term prognosis of patients with variant angina. A comparative study between western and Japanese populations.
International journal of cardiology 1988;18(3):331-49.
1988: Miyamoto S; Shimokawa H; Sumioki H; Touno A; Nakano H
Circadian rhythm of plasma atrial natriuretic peptide, aldosterone, and blood pressure during the third trimester in normal and preeclamptic pregnancies.
American journal of obstetrics and gynecology 1988;158(2):393-9.
1988: Kurokawa T; Miyamoto S; Uchiumi Y; Higashihara J; Shimokawa H; Nakano H
[The influence of gestational edema on maternal and perinatal outcome]
Nippon Sanka Fujinka Gakkai zasshi 1988;40(1):9-13.
1988: Maeda H; Shimokawa H; Nakano H
Effects of intrauterine treatment on nonimmunologic hydrops fetalis.
Fetal therapy 1988;3(4):198-209.
1988: Kubota S; Koyanagi T; Hori E; Hara K; Shimokawa H; Nakano H
Homeothermal adjustment in the immediate postdelivered infant monitored by continuous and simultaneous measurement of core and peripheral body temperatures.
Biology of the neonate 1988;54(2):79-85.
1988: Shimokawa H; Hara K; Maeda H; Miyamoto S; Koyanagi T; Nakano H
Intrauterine treatment of idiopathic hydrops fetalis.
Journal of perinatal medicine 1988;16(2):133-8.
1988: Shimokawa H; Sumioki H; Miyamoto S; Maeda H; Yamaguchi Y; Nakano H
Is human atrial natriuretic peptide in fetal blood useful as a parameter to detect the decompensate state of the fetal heart?
Journal of perinatal medicine 1988;16(5-6):485-6.
1987: Nakano H; Shimokawa H
[Medical care system for mother, fetus and newborn--what should be in mind for systematization]
Nippon Sanka Fujinka Gakkai zasshi 1987;39(11):2081-5.
1987: Nakahara H; Koyanagi T; Teraoka H; Shimokawa H; Hara K; Nakano H
Microcomputer-based local area network system for controlling information on perinatal medicine.
International journal of bio-medical computing 1987;21(2):83-93.
1987: Nabeyama S; Tomoike H; Hisano K; Shimokawa H; Inoue T; Yamamoto H; Nakamura M
Collateral function modified by glyceryl trinitrate and dipyridamole during coronary occlusion in conscious dogs.
Cardiovascular research 1987;21(3):177-87.
1987: Yamaguchi Y; Shimokawa H; Hori E; Matsumoto N; Nakano H; Suita S; Kukita J
Measurement of the fetal urine production rate using real-time ultrasound in fetuses with bilateral hydronephrosis.
Fetal therapy 1987;2(4):197-202.
1986: Kashiwabara Y; Maeda H; Yamaguchi Y; Shimokawa H; Hisanaga S; Nakano H
[Studies on surface tension of amniotic fluid with special emphasis on evaluating fetal lung maturity]
Nippon Sanka Fujinka Gakkai zasshi 1986;38(3):346-54.
1985: Shimokawa H; Hisanaga S; Maesato S; Kashiwabara Y; Maeda H; Oki S; Nakano H
Correlation between amniotic fluid lecithin-sphingomyelin (L/S) ratio and optical density measured after centrifugation at varying forces.
Asia-Oceania journal of obstetrics and gynaecology / AOFOG 1985;11(2):265-70.
1985: Umezu T; Hisanaga S; Shimokawa H; Kashiwabara Y; Maesato S
Origin of lysozyme in amniotic fluid.
Nippon Sanka Fujinka Gakkai zasshi 1985;37(2):301-3.
1984: Hisanaga S; Shimokawa H; Kashiwabara Y; Maesato S; Nakano H
Unexpectedly low lecithin/sphingomyelin ratio associated with fetal diaphragmatic hernia.
American journal of obstetrics and gynecology 1984;149(8):905-6.
1984: Kashiwabara Y; Shimokawa H; Maesato S; Hisanaga S; Nakano H
[Origin of low molecular weight protein in amniotic fluid]
Nippon Sanka Fujinka Gakkai zasshi 1984;36(5):705-9.
1983: Hisanaga S; Shimokawa H; Kurokawa T; Maesato S; Nakano H
Relation of the site of congenital upper gastrointestinal obstruction to amniotic fluid bilirubin concentration.
Asia-Oceania journal of obstetrics and gynaecology / AOFOG 1983;9(4):435-8.
1983: Hisanaga S; Shimokawa H; Matsuo T; Umezu T; Maesato S; Kashiwabara Y; Nakano H
Evaluation of amniocentesis guided by real-time ultrasonic tomography.
Nippon Sanka Fujinka Gakkai zasshi 1983;35(7):981-4.
1982: Hisanaga S; Umezu T; Shimokawa H; Maesato S
Amniotic fluid lysozyme content in normal and abnormal pregnancy.
Nippon Sanka Fujinka Gakkai zasshi 1982;34(4):541-4.
1981: Maesato S; Shimokawa H; Hisanaga S
[Changes of the amniotic fluid proteins on the basis of molecular weight (author's transl)]
Nippon Sanka Fujinka Gakkai zasshi 1981;33(12):2047-54.

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