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Isao Shimokawa

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Takuya Chiba; Ryoichi Mori; Tomoshi Tsuchiya; Isao Shimokawa
Protein reporter bioassay systems for the phenotypic screening of candidate drugs: a mouse platform for anti-aging drug screening.
Hideki Hayashi; Ichiro Katayama; Tohru Kimura; Tomoko Kohno; Yoshinao Kubo; Yuhua Ma; Tak Wah Mak; Hiroyuki Murota; Tomoki Nakashima; Isao Shimokawa; Takashi Suematsu; Kazuo Yamamoto; Kiyoshi Yasui; Shizuo Akira; Koon Jiew Chua; Gordon S Duncan; Toshifumi Matsuyama
Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription.
Ryoichi Mori; Momoko Okamoto; Isao Shimokawa; Takuya Chiba; Kazuya Ikematsu; Sang E Kim; Tetsuya Kitaguchi; Atsushi Miyawaki; Takashi Tsuboi
Release of TNF-α from macrophages is mediated by small GTPase Rab37.

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2012: Takuya Chiba; Ryoichi Mori; Tomoshi Tsuchiya; Isao Shimokawa
Protein reporter bioassay systems for the phenotypic screening of candidate drugs: a mouse platform for anti-aging drug screening.
Sensors (Basel, Switzerland) 2012;12(2):1648-56.
2011: Hideki Hayashi; Ichiro Katayama; Tohru Kimura; Tomoko Kohno; Yoshinao Kubo; Yuhua Ma; Tak Wah Mak; Hiroyuki Murota; Tomoki Nakashima; Isao Shimokawa; Takashi Suematsu; Kazuo Yamamoto; Kiyoshi Yasui; Shizuo Akira; Koon Jiew Chua; Gordon S Duncan; Toshifumi Matsuyama
Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(46):18766-71.
2011: Ryoichi Mori; Momoko Okamoto; Isao Shimokawa; Takuya Chiba; Kazuya Ikematsu; Sang E Kim; Tetsuya Kitaguchi; Atsushi Miyawaki; Takashi Tsuboi
Release of TNF-α from macrophages is mediated by small GTPase Rab37.
European journal of immunology 2011;41(11):3230-9.
2011: Takahiro Hayashida; Yasuko Henmi; Ae Ra Kim; Toshimitsu Komatsu; Takuya Chiba; Hae Young Chung; Shinji Goto; Kurumi Yanagihara-Ota; Isao Shimokawa
Modest inhibition of the growth hormone axis does not affect mitochondrial reactive oxygen species generation or redox state, unlike calorie restriction.
Geriatrics & gerontology international 2011;11(4):496-503.
2011: Susumu Eguchi; Mitsuhisa Takatsuki; Masaaki Hidaka; Akihiko Soyama; Izumi Muraoka; Tetsuo Tomonaga; Isao Shimokawa; Takashi Kanematsu
Lack of grafted liver rejuvenation in adult-to-pediatric liver transplantation.
Digestive diseases and sciences 2011;56(5):1542-7.
2011: Toshimitsu Komatsu; Lucas S Trindade; Takuya Chiba; Hiroko Hayashi; Tomoko Henmi; Yoko Ushiroda; Ryoichi Mori; Isao Shimokawa
Acute stress response modified by modest inhibition of growth hormone axis: a potential machinery of the anti-aging effect of calorie restriction.
Mechanisms of ageing and development 2011;132(3):103-9.
2011: Sayaka Kuba; Hiroshi Ohtani; Junzo Yamaguchi; Hiroko Hayashi; Tatsuya Uga; Takashi Kanematsu; Isao Shimokawa
Incomplete inside-out growth pattern in invasive breast carcinoma: association with lymph vessel invasion and recurrence-free survival.
Virchows Archiv : an international journal of pathology 2011;458(2):159-69.
2010: Takuya Chiba; Tomoshi Tsuchiya; Toshimitsu Komatsu; Ryoichi Mori; Hiroko Hayashi; Isao Shimokawa
Development of calorie restriction mimetics as therapeutics for obesity, diabetes, inflammatory and neurodegenerative diseases.
Current genomics 2010;11(8):562-7.
2010: Takuya Chiba; Tomoshi Tsuchiya; Toshimitsu Komatsu; Ryoichi Mori; Hiroko Hayashi; Hitoshi Shimano; Stephen R Spindler; Isao Shimokawa
Development of a bioassay to screen for chemicals mimicking the anti-aging effects of calorie restriction.
Biochemical and biophysical research communications 2010;401(2):213-8.
2010: Isao Shimokawa; Lucas S Trindade
Dietary restriction and aging in rodents: a current view on its molecular mechanisms.
Aging and disease 2010;1(2):89-107.
2010: Haruyoshi Yamaza; Toshimitsu Komatsu; Saori Wakita; Carole Kijogi; Seongjoon Park; Hiroko Hayashi; Takuya Chiba; Ryoichi Mori; Tatsuo Furuyama; Nozomu Mori; Isao Shimokawa
FoxO1 is involved in the antineoplastic effect of calorie restriction.
Aging cell 2010;9(3):372-82.
2009: Takuya Chiba; Toshimitsu Komatsu; Masahiko Nakayama; Toshiyuki Adachi; Yukari Tamashiro; Hiroko Hayashi; Haruyoshi Yamaza; Yoshikazu Higami; Isao Shimokawa
Similar metabolic responses to calorie restriction in lean and obese Zucker rats.
Molecular and cellular endocrinology 2009;309(1-2):17-25.
2009: Seongjoon Park; Toshimitsu Komatsu; Hiroko Hayashi; Lucas Siqueira Trindade; Haruyoshi Yamaza; Takuya Chiba; Isao Shimokawa
Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling.
Experimental gerontology 2009;44(10):646-52.
2009: Isao Shimokawa
[Mechanisms underlying the aging process and the anti-aging strategy].
Nihon rinsho. Japanese journal of clinical medicine 2009;67(7):1265-70.
2009: Isao Shimokawa; Sang Chul Park; Susumu Mori; Eun Seong Hwang
Japan-Korea joint seminar: Asian aging core for longevity 2008 in Nagasaki - toward the establishment of an Asian aging research and education center - September 4th to 6th, 2008 at Huis ten Bosch, Nagasaki, Japan.
Mechanisms of ageing and development 2009;130(3):198-201.
2009: Takuya Chiba; Daisuke Inoue; Aya Mizuno; Toshimitsu Komatsu; Satoshi Fujita; Haruaki Kubota; Maria Luisa Tagliaro; Seongjoon Park; Lucas Siqueira Trindade; Takahiro Hayashida; Hiroko Hayashi; Haruyoshi Yamaza; Yoshikazu Higami; Isao Shimokawa
Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain: implications for longevity.
Neurobiology of aging 2009;30(3):474-82.
2008: Seongjoon Park; Toshimitsu Komatsu; Hiroko Hayashi; Haruyoshi Yamaza; Takuya Chiba; Yoshikazu Higami; Kazunao Kuramoto; Isao Shimokawa
Calorie restriction initiated at a young age activates the Akt/PKC zeta/lambda-Glut4 pathway in rat white adipose tissue in an insulin-independent manner.
Age (Dordrecht, Netherlands) 2008;30(4):293-302.
2008: Isao Shimokawa; Takuya Chiba; Haruyoshi Yamaza; Toshimitsu Komatsu
Longevity genes: insights from calorie restriction and genetic longevity models.
Molecules and cells 2008;26(5):427-35.
2008: Tomoko Kohno; Tsutomu Daa; Hiroshi Otani; Isao Shimokawa; Shigeo Yokoyama; Toshifumi Matsuyama
Aberrant expression of BAFF receptor, a member of the tumor necrosis factor receptor family, in malignant cells of nonhematopoietic origins.
Genes to cells : devoted to molecular & cellular mechanisms 2008;13(10):1061-73.
2008: Hiroko Hayashi; Haruyoshi Yamaza; Toshimitsu Komatsu; Seongjoon Park; Takuya Chiba; Yoshikazu Higami; Takeshi Nagayasu; Isao Shimokawa
Calorie restriction minimizes activation of insulin signaling in response to glucose: potential involvement of the growth hormone-insulin-like growth factor 1 axis.
Experimental gerontology 2008;43(9):827-32.
2008: Takuya Chiba; Haruyoshi Yamaza; Toshimitsu Komatsu; Masahiko Nakayama; Satoshi Fujita; Hiroko Hayashi; Yoshikazu Higami; Isao Shimokawa
Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness: relationship with caloric restriction.
Experimental gerontology 2008;43(6):595-600.
2008: Toshimitsu Komatsu; Takuya Chiba; Haruyoshi Yamaza; Kimihiro Yamashita; Atsuyoshi Shimada; Yasuyo Hoshiyama; Tomoko Henmi; Hiroshi Ohtani; Yoshikazu Higami; Rafael de Cabo; Donald Ingram; Isao Shimokawa
Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8.
Experimental gerontology 2008;43(4):339-46.
2008: Hiroshi Ohtani; Hiroko Hayashi; Yoshikazu Higami; Kazuhiko Takuma; Kenjiro Minami; Yasuhiro Minami; Isao Shimokawa
Acute gastritis associated with invading Helicobacter heilmannii organisms from a previously homeless cat.
Journal of clinical gastroenterology 2008;42(2):216-7.
2008: Yan Zha; Takashi Taguchi; Arifa Nazneen; Isao Shimokawa; Yoshikazu Higami; Mohammed S Razzaque
Genetic suppression of GH-IGF-1 activity, combined with lifelong caloric restriction, prevents age-related renal damage and prolongs the life span in rats.
American journal of nephrology 2008;28(5):755-64.
2007: Takuya Chiba; Haruyoshi Yamaza; Isao Shimokawa
Role of insulin and growth hormone/insulin-like growth factor-I signaling in lifespan extension: rodent longevity models for studying aging and calorie restriction.
Current genomics 2007;8(7):423-8.
2007: Takuya Chiba; Satoshi Fujita; Haruaki Kubota; Daisuke Inoue; Aya Mizuno; Toshimitsu Komatsu; Haruyoshi Yamaza; Yoshikazu Higami; Isao Shimokawa
Identification of fasting-induced genes in the rat hypothalamus: relationship with neuroprotection.
Annals of the New York Academy of Sciences 2007;1119():216-26.
2007: Kazuo To; Haruyoshi Yamaza; Toshimitsu Komatsu; Takahiro Hayashida; Hiroko Hayashi; Hiroaki Toyama; Takuya Chiba; Yoshikazu Higami; Isao Shimokawa
Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver.
Experimental gerontology 2007;42(11):1063-71.
2007: Takuya Chiba; Junjie Yao; Yoshikazu Higami; Isao Shimokawa; Masanori Hosokawa; Keiichi Higuchi
Identification of differentially expressed genes in senescence-accelerated mouse testes by suppression subtractive hybridization analysis.
Mammalian genome : official journal of the International Mammalian Genome Society 2007;18(2):105-12.
2007: Haruyoshi Yamaza; Toshimitsu Komatsu; Kazuo To; Hiroaki Toyama; Takuya Chiba; Yoshikazu Higami; Isao Shimokawa
Involvement of insulin-like growth factor-1 in the effect of caloric restriction: regulation of plasma adiponectin and leptin.
The journals of gerontology. Series A, Biological sciences and medical sciences 2007;62(1):27-33.
2006: Yan Zha; Viet Thang Le; Yoshikazu Higami; Isao Shimokawa; Takashi Taguchi; Mohammed S Razzaque
Life-long suppression of growth hormone-insulin-like growth factor I activity in genetically altered rats could prevent age-related renal damage.
Endocrinology 2006;147(12):5690-8.
2006: Yoshikazu Higami; Tomoshi Tsuchiya; Takuya Chiba; Haruyoshi Yamaza; Izumi Muraoka; Megumi Hirose; Toshimitsu Komatsu; Isao Shimokawa
Hepatic gene expression profile of lipid metabolism in rats: Impact of caloric restriction and growth hormone/insulin-like growth factor-1 suppression.
The journals of gerontology. Series A, Biological sciences and medical sciences 2006;61(11):1099-110.
2006: Hiroko Hayashi; Hiroshi Ohtani; Takashi Ueda; Junzo Yamaguchi; Kunihide Izawa; Takahiro Hayashida; Yoshikazu Higami; Isao Shimokawa
Primary hepatic lymphoma with spindle cell components: a case report.
Virchows Archiv : an international journal of pathology 2006;449(5):591-6.
2006: Toshimitsu Komatsu; Takuya Chiba; Haruyoshi Yamaza; Kazuo To; Hiroaki Toyama; Yoshikazu Higami; Isao Shimokawa
Effect of leptin on hypothalamic gene expression in calorie-restricted rats.
The journals of gerontology. Series A, Biological sciences and medical sciences 2006;61(9):890-8.
2006: Seongjoon Park; Toshimitsu Komatsu; Hiroko Hayashi; Haruyoshi Yamaza; Takuya Chiba; Yoshikazu Higami; Kazunao Kuramoto; Isao Shimokawa
Calorie restriction initiated at middle age improved glucose tolerance without affecting age-related impairments of insulin signaling in rat skeletal muscle.
Experimental gerontology 2006;41(9):837-45.
2006: Tomoshi Tsuchiya; Hiroshi Ohtani; Hikaru Fujioka; Akihiko Mizoe; Yoshikazu Higami; Isao Shimokawa
Fatal Alcaligenes xylosoxidans infection of the liver: presenting as a liver mass after cholecystectomy.
Journal of gastroenterology and hepatology 2006;21(6):1081-2.
2005: Tomoshi Tsuchiya; Yoshikazu Higami; Toshimitsu Komatsu; Kenji Tanaka; Sumihisa Honda; Haruyoshi Yamaza; Takuya Chiba; Hiroyoshi Ayabe; Isao Shimokawa
Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation.
Mechanisms of ageing and development 2005;126(5):568-79.
2005: Hiroaki Kawano; Takahiro Hayashida; Hiroshi Ohtani; Munetake Kanda; Yuji Koide; Takeshi Baba; Genji Toda; Isao Shimokawa; Katsusuke Yano; Ryozo Okada
Histopathological findings of the no-reflow phenomenon following coronary intervention for acute coronary syndrome.
International heart journal 2005;46(2):327-32.
2005: Yoshikazu Higami; Haruyoshi Yamaza; Isao Shimokawa
Laboratory findings of caloric restriction in rodents and primates.
Advances in clinical chemistry 2005;39():211-37.
2004: Yoshikazu Higami; Tomoshi Tsuchiya; Kazuo To; Takuya Chiba; Haruyoshi Yamaza; Daisuke Shiokawa; Sei-ichi Tanuma; Isao Shimokawa
Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes.
Cell and tissue research 2004;316(3):403-7.
2004: Haruyoshi Yamaza; Toshimitsu Komatsu; Takuya Chiba; Hiroaki Toyama; Kazuo To; Yoshikazu Higami; Isao Shimokawa
A transgenic dwarf rat model as a tool for the study of calorie restriction and aging.
Experimental gerontology 2004;39(2):269-72.
2004: Kenji Tanaka; Yoshikazu Higami; Tomoshi Tsuchiya; Daisuke Shiokawa; Sei-ichi Tanuma; Hiroyoshi Ayabe; Isao Shimokawa
Aging increases DNase gamma, an apoptosis-related endonuclease, in rat liver nuclei: effect of dietary restriction.
Experimental gerontology 2004;39(2):195-202.
2004: Fumio Kitaoka; Toshiaki Shiogama; Akimasa Mizutani; Yasutaka Tsurunaga; Hiroshi Fukui; Yoshikazu Higami; Isao Shimokawa; Takashi Taguchi; Takashi Kanematsu
A solitary Peutz-Jeghers-type hamartomatous polyp in the duodenum. A case report including results of mutation analysis.
Digestion 2004;69(2):79-82.
2003: Yoshikazu Higami; Kazuo To; Hiroshi Ohtani; Kenta Masui; Keisuke Iwasaki; Daisuke Shiokawa; Sei-ichi Tanuma; Isao Shimokawa
Involvement of DNase gamma in apoptotic DNA fragmentation in histiocytic necrotizing lymphadenitis.
Virchows Archiv : an international journal of pathology 2003;443(2):170-4.
2003: Manabu Matsuo; Shigehiko Koga; Hiroshi Kanetake; Hiroshi Ohtani; Yoshikazu Higami; Isao Shimokawa; Jun-ichi Watanabe
EPO-producing gastric carcinoma in a hemodialysis patient.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2003;42(1):E3-4.
2003: Isao Shimokawa; Yoshikazu Higami; Tomoshi Tsuchiya; Hiroshi Otani; Toshimitsu Komatsu; Takuya Chiba; Haruyoshi Yamaza
Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1108-9.
2003: Isao Shimokawa; Tamaki Fukuyama; Kurumi Yanagihara-Outa; Masato Tomita; Toshimitsu Komatsu; Yoshikazu Higami; Tomoshi Tuchiya; Takuya Chiba; Yoshiharu Yamaza
Effects of caloric restriction on gene expression in the arcuate nucleus.
Neurobiology of aging 2003;24(1):117-23.
2002: Tatsuo Furuyama; Hitoshi Yamashita; Kazuko Kitayama; Yoshikazu Higami; Isao Shimokawa; Nozomu Mori
Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles.
Microscopy research and technique 2002;59(4):331-4.
2002: Haruyoshi Yamaza; Takuya Chiba; Yoshikazu Higami; Isao Shimokawa
Lifespan extension by caloric restriction: an aspect of energy metabolism.
Microscopy research and technique 2002;59(4):325-30.
2002: Takuya Chiba; Haruyoshi Yamaza; Yoshikazu Higami; Isao Shimokawa
Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling.
Microscopy research and technique 2002;59(4):317-24.
2002: Toshio Kawahara; Isao Shimokawa; Masato Tomita; Toru Hirano; Hiroyuki Shindo
Effects of caloric restriction on development of the proximal growth plate and metaphysis of the caput femoris in spontaneously hypertensive rats: microscopic and computer-assisted image analyses.
Microscopy research and technique 2002;59(4):306-12.
2002: Kohei Ando; Yoshikazu Higami; Tomoshi Tsuchiya; Takashi Kanematsu; Isao Shimokawa
Impact of aging and life-long calorie restriction on expression of apoptosis-related genes in male F344 rat liver.
Microscopy research and technique 2002;59(4):293-300.
2002: Shu Inuzuka; Shigehiko Koga; Masaharu Nishikido; Yasuyoshi Miyata; Shigeru Kanda; Isao Shimokawa; Mitsuko Tanaka; Yutaka Saito; Hiroshi Kanetake
Donor-specific blood transfusion prolongs cardiac allograft survival in rats by low nitric oxide production and elevated serum levels of prostaglandin E(2).
Immunology letters 2002;83(2):119-24.
2002: Isao Shimokawa; Yoshikazu Higami; Masanori Utsuyama; Tomoshi Tuchiya; Toshimitsu Komatsu; Takuya Chiba; Haruyoshi Yamaza
Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model.
The American journal of pathology 2002;160(6):2259-65.
2001: T Tsuchiya; Isao Shimokawa; Yoshikazu Higami; H Ohtani; Y Shigeoka; K Ohshima; K Tanaka; H Ayabe
Primary low-grade MALT lymphoma of the gallbladder.
Pathology international 2001;51(12):965-9.
2001: Isao Shimokawa; Yoshikazu Higami
Leptin signaling and aging: insight from caloric restriction.
Mechanisms of ageing and development 2001;122(14):1511-9.
2001: M Tomita; Isao Shimokawa; Yoshikazu Higami; K Yanagihara-Outa; T Kawahara; K Tanaka; T Ikeda; H Shindo
Modulation by dietary restriction in gene expression related to insulin-like growth factor-1 in rat muscle.
Aging (Milan, Italy) 2001;13(4):273-81.
2001: Isao Shimokawa; Yoshikazu Higami
Leptin and anti-aging action of caloric restriction.
The journal of nutrition, health & aging 2001;5(1):43-8.
2000: Yoshikazu Higami; K Tanaka; T Tsuchiya; Isao Shimokawa
Intravenous injection of cycloheximide induces apoptosis and up-regulates p53 and Fas receptor expression in the rat liver in vivo.
Mutation research 2000;457(1-2):105-11.
2000: Yoshikazu Higami; Isao Shimokawa
Apoptosis in the aging process.
Cell and tissue research 2000;301(1):125-32.
2000: Isao Shimokawa; K Yanagihara; Yoshikazu Higami; T Okimoto; M Tomita; T Ikeda; S Lee
Effects of aging and dietary restriction on mRNA levels of receptors for growth hormone-releasing hormone and somatostatin in the rat pituitary.
The journals of gerontology. Series A, Biological sciences and medical sciences 2000;55(6):B274-9.
2000: Yoshikazu Higami; Isao Shimokawa; K Ando; K Tanaka; T Tsuchiya
Dietary restriction reduces hepatocyte proliferation and enhances p53 expression but does not increase apoptosis in normal rats during development.
Cell and tissue research 2000;299(3):363-9.
1999: Isao Shimokawa; Yoshikazu Higami
A role for leptin in the antiaging action of dietary restriction: a hypothesis.
Aging (Milan, Italy) 1999;11(6):380-2.
1999: Mohammed S Razzaque; Isao Shimokawa; T Koji; Yoshikazu Higami; T Taguchi
Life-long caloric restriction suppresses age-associated Fas expression in the Fischer 344 rat kidney.
Molecular cell biology research communications : MCBRC 1999;1(1):82-5.
1999: M Tomita; Isao Shimokawa; H Maeda; Yoshikazu Higami; T Kawahara; T Ikeda; T Hirano
Dietary restriction reduces the prevalence of osteonecrosis of the caput femoris in spontaneously hypertensive rats.
Calcified tissue international 1999;64(3):259-62.
1999: Mohammed S Razzaque; Isao Shimokawa; Arifa Nazneen; Diange Liu; Takashi Naito; Yoshikazu Higami; Takashi Taguchi
Life-long dietary restriction modulates the expression of collagens and collagen-binding heat shock protein 47 in aged Fischer 344 rat kidney.
The Histochemical journal 1999;31(2):123-32.
1998: Mohammed S Razzaque; Isao Shimokawa; Arifa Nazneen; Yoshikazu Higami; Takashi Taguchi
Age-related nephropathy in the Fischer 344 rat is associated with overexpression of collagens and collagen-binding heat shock protein 47.
Cell and tissue research 1998;293(3):471-8.
1998: Yoshikazu Higami; Isao Shimokawa; M Kishikawa; T Okimoto; H Ohtani; M Tomita; A Tsujino; T Ikeda
Malignant peripheral nerve sheath tumors developing multifocally in the central nervous system in a patient with neurofibromatosis type 2.
Clinical neuropathology 1998;17(2):115-20.
1998: Isao Shimokawa; Yoshikazu Higami; S Horiuchi; M Iwasaki; T Ikeda
Advanced glycosylation end products in adrenal lipofuscin.
The journals of gerontology. Series A, Biological sciences and medical sciences 1998;53(1):B49-51.
1997: Yoshikazu Higami; Isao Shimokawa; M Tomita; T Okimoto; T Koji; N Kobayashi; T Ikeda
Aging accelerates but life-long dietary restriction suppresses apoptosis-related Fas expression on hepatocytes.
The American journal of pathology 1997;151(3):659-63.
1997: K Murata; M Fujita; Yasuaki Yamada; Yoshikazu Higami; Isao Shimokawa; Kunihiro Tsukasaki; Y Tanaka; M Maeda; K Furukawa; T Yoshiki; H Shiku; Masao Tomonaga
In vivo retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for adult T cell leukemia in a rat model.
Japanese journal of cancer research : Gann 1997;88(5):492-500.
1997: Isao Shimokawa; Yoshikazu Higami; T Okimoto; M Tomita; T Ikeda
Effect of somatostatin-28 on growth hormone response to growth hormone-releasing hormone--impact of aging and lifelong dietary restriction.
Neuroendocrinology 1997;65(5):369-76.
1997: Yoshikazu Higami; Isao Shimokawa; T Okimoto; M Tomita; T Yuo; T Ikeda
Effect of aging and dietary restriction on hepatocyte proliferation and death in male F344 rats.
Cell and tissue research 1997;288(1):69-77.
1997: Roger McCarter; Isao Shimokawa; Yuji Ikeno; Yoshikazu Higami; Gene B Hubbard; Byung Pal Yu; C Alex McMahan
Physical activity as a factor in the action of dietary restriction on aging: effects in Fischer 344 rats.
Aging (Milan, Italy) 1997;9(1-2):73-9.
1997: T Okimoto; Isao Shimokawa; Yoshikazu Higami; T Ikeda
VEGF and bFGF mRNA are expressed in ethylnitrosourea-induced experimental rat gliomas.
Cellular and molecular neurobiology 1997;17(1):141-50.
1996: Isao Shimokawa; Yoshikazu Higami; T Okimoto; M Tomita; T Ikeda
Effects of lifelong dietary restriction on somatotropes: immunohistochemical and functional aspects.
The journals of gerontology. Series A, Biological sciences and medical sciences 1996;51(6):B396-402.
1996: Yoshikazu Higami; Isao Shimokawa; T Okimoto; M Tomita; T Yuo; T Ikeda
Susceptibility of hepatocytes to cell death induced by single administration of cycloheximide in young and old F344 rats. Effect of dietary restriction.
Mutation research 1996;357(1-2):225-30.
1996: M Tomita; Isao Shimokawa; T Ikeda; K Iwasaki; Yoshikazu Higami; H Ohtani; T Matsushita; J Fukui; Masahiro Shikuwa
Spontaneous rupture of non-aneurysmal ascending aorta.
Pathology international 1996;46(9):667-72.
1996: Isao Shimokawa; Yoshikazu Higami; B P Yu; E J Masoro; T Ikeda
Influence of dietary components on occurrence of and mortality due to neoplasms in male F344 rats.
Aging (Milan, Italy) 1996;8(4):254-62.
1996: Isao Shimokawa; B P Yu; Yoshikazu Higami; T Ikeda
Morphometric analysis of somatotrophs: effects of age and dietary restriction.
Neurobiology of aging 1996;17(1):79-86.
1995: Yoshikazu Higami; Isao Shimokawa; T Okimoto; H Otani; M Kishikawa; T Zinnouchi; T Hiura; S Nishimura; T Ikeda
Minigemistocytic astrocytoma with frequent apoptoses: analysis of tumor growth.
Pathology international 1995;45(8):610-5.
1995: Yoshikazu Higami; B P Yu; Isao Shimokawa; H Bertrand; G B Hubbard; E J Masoro
Anti-tumor action of dietary restriction is lesion-dependent in male Fischer 344 rats.
The journals of gerontology. Series A, Biological sciences and medical sciences 1995;50(2):B72-7.
1995: Edward J Masoro; Isao Shimokawa; Yoshikazu Higami; C A McMahan; B P Yu
Temporal pattern of food intake not a factor in the retardation of aging processes by dietary restriction.
The journals of gerontology. Series A, Biological sciences and medical sciences 1995;50A(1):B48-53.
1994: Isao Shimokawa; Yoshikazu Higami; T Okimoto; T Ikeda
The growth hormone-releasing hormone-cyclic adenosine-3',5'-monophosphate signal pathway in somatotropes is practically intact during aging.
Neuroendocrinology 1994;60(6):575-80.
1994: Yoshikazu Higami; Isao Shimokawa; T Okimoto; T Ikeda
Vulnerability to oxygen radicals is more important than impaired repair in hepatocytic deoxyribonucleic acid damage in aging.
Laboratory investigation; a journal of technical methods and pathology 1994;71(5):650-6.
1994: Yoshikazu Higami; B P Yu; Isao Shimokawa; E J Masoro; T Ikeda
Duration of dietary restriction: an important determinant for the incidence and age of onset of leukemia in male F344 rats.
Journal of gerontology 1994;49(5):B239-44.
1994: Edward J Masoro; C A McMahan; Isao Shimokawa; Yoshikazu Higami; Byung Pal Yu
Longitudinal study of the hematocrit of ad libitum fed and dietary restricted male F344 rats.
Aging (Milan, Italy) 1994;6(4):287-92.
1994: Yoshikazu Higami; Isao Shimokawa; T Okimoto; T Ikeda
An age-related increase in the basal level of DNA damage and DNA vulnerability to oxygen radicals in the individual hepatocytes of male F344 rats.
Mutation research 1994;316(2):59-67.
1993: Yuji Ikeno; Isao Shimokawa; Yoshikazu Higami; T Ikeda
GFAP expression in the subcutaneous tumors of immature glial cell line (HITS glioma) derived from ENU-induced rat glioma.
Journal of neuro-oncology 1993;17(3):191-204.
1993: Isao Shimokawa; N Ushijima; R Moriuchi; T Okimoto; T Ikeda; K Iwasaki; T Matsuo
A case of angiocentric immunoproliferative lesions (angiocentric lymphoma) associated with human T-cell lymphotropic virus type 1.
Human pathology 1993;24(8):921-3.
1993: Isao Shimokawa; B P Yu; Yoshikazu Higami; T Ikeda; E J Masoro
Dietary restriction retards onset but not progression of leukemia in male F344 rats.
Journal of gerontology 1993;48(2):B68-73.
1993: Yuji Ikeno; Sadahiro Asai; H Mashimoto; Isao Shimokawa; K Iwasaki; T Matsuo; T Ikeda; H Minami
[A case of pulmonary asbestosis with slightly increased serum IgE concentration and histopathological changes resembling DIP].
Nihon Kyōbu Shikkan Gakkai zasshi 1993;31(2):219-24.
1993: Isao Shimokawa; Yoshikazu Higami; G B Hubbard; C A McMahan; Edward J Masoro; Byung Pal Yu
Diet and the suitability of the male Fischer 344 rat as a model for aging research.
Journal of gerontology 1993;48(1):B27-32.
1992: Fuminao Takeshima; K Iwasaki; Isao Shimokawa; T Ikeda; T Matsuo
Immunohistochemical localization of gangliosides in ENU-induced rat glioma.
Acta pathologica japonica 1992;42(8):558-65.
1991: Isao Shimokawa; B P Yu; E J Masoro
Influence of diet on fatal neoplastic disease in male Fischer 344 rats.
Journal of gerontology 1991;46(6):B228-32.
1991: Isao Shimokawa; Yoshikazu Higami; H Sakai; Y Moriuchi; K Murase; T Ikeda
Intravascular malignant lymphomatosis: a case of T-cell lymphoma probably associated with human T-cell lymphotropic virus.
Human pathology 1991;22(2):200-2.
1991: Edward J Masoro; Isao Shimokawa; Byung Pal Yu
Retardation of the aging processes in rats by food restriction.
Annals of the New York Academy of Sciences 1991;621():337-52.
1989: T Ikeda; H Mashimoto; K Iwasaki; Isao Shimokawa; T Matsuo
A sequential ultrastructural and histoautoradiographic study of early neoplastic lesions in ethylnitrosourea-induced rat glioma.
Acta pathologica japonica 1989;39(8):487-95.
1988: Yoshikazu Higami; T Matsuo; Isao Shimokawa; K Iwasaki; T Ikeda; M Kawatomi
[An autopsy case of pulmonary diffuse alveolar septal amyloidosis secondary to miliary tuberculosis].
Nihon Kyōbu Shikkan Gakkai zasshi 1988;26(9):995-9.
1988: K Iwasaki; H Maeda; Isao Shimokawa; M Hayashida; B P Yu; E J Masoro; T Ikeda
An electron microscopic examination of age-related changes in the rat liver. The influence of diet.
Acta pathologica japonica 1988;38(9):1119-30.
1987: Isao Shimokawa; H Maeda; S Tokunaga; H Mashimoto; T Matsuo; T Ikeda
[The nature of immunohistochemically defined astrocytic cells in rat gliomas].
Nō to shinkei = Brain and nerve 1987;39(9):861-8.
1987: H Maeda; T Matsuo; Isao Shimokawa; H Mashimoto; T Ikeda; T Ohshima; T Koteda
[Two cases of mediastinal germ cell tumor with high serum alpha-fetoprotein--with special reference to 33 cases of yolk sac tumor].
Nihon Kyōbu Shikkan Gakkai zasshi 1987;25(9):1032-8.