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Iichiro Shimomura
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75
Funahashi, Tohru
56
Kihara, Shinji
55
Matsuzawa, Yuji
49
Matsuda, Morihiro
35
Nakamura, Tadashi
30
Maeda, Norikazu
25
Nishizawa, Hitoshi
24
Fukuhara, Atsunori
20
Nishida, Makoto
20
Yamagata, Kazuya
18
Yamashita, Shizuya
18
Kishida, Ken
17
Kuriyama, Hiroshi
17
Miyagawa, Jun-ichiro
16
Komuro, Ryutaro
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Geonetwork of Iichiro Shimomura (preview)
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All Publications
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2009: Saisho Kenji; Fukuhara Atsunori; Yasuda Tomoko; Sato Yoshifumi; Fukui Kenji; Iwahashi Hiromi; Imagawa Akihisa; Hatta Mitsutoki; Shimomura Iichiro; Yamagata Kazuya
Glucose enhances collectrin protein expression in insulin-producing MIN6 beta cells.
Biochemical and biophysical research communications 2009;389(1):133-7.
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2009: Kamada Yoshihiro; Nakamura Tadashi; Funahashi Tohru; Ryo Miwa; Nishizawa Hitoshi; Okauchi Yukiyoshi; Fukushima Juichi; Yoshida Yuichi; Kiso Shinichi; Shimomura Iichiro; Hayashi Norio
Visceral obesity and hypoadiponectinemia are significant determinants of hepatic dysfunction: An epidemiologic study of 3827 Japanese subjects.
Journal of clinical gastroenterology 2009;43(10):995-1000.
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2009: Okauchi Yukiyoshi; Kishida Ken; Funahashi Tohru; Noguchi Midori; Ogawa Tomoko; Ryo Miwa; Okita Kohei; Iwahashi Hiromi; Imagawa Akihisa; Nakamura Tadashi; Matsuzawa Yuji; Shimomura Iichiro
Changes in serum adiponectin concentrations correlate with changes in BMI, waist circumference, and estimated visceral fat area in middle-aged general population.
Diabetes care 2009;32(10):e122.
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2009: Takaoka Minoru; Nagata Daisuke; Kihara Shinji; Shimomura Iichiro; Kimura Yu; Tabata Yasuhiko; Saito Yoshihiko; Nagai Ryozo; Sata Masataka
Periadventitial adipose tissue plays a critical role in vascular remodeling.
Circulation research 2009;105(9):906-11.
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2009: Hirata Ayumu; Maeda Norikazu; Hiuge Aki; Hibuse Toshiyuki; Fujita Koichi; Okada Takuya; Kihara Shinji; Funahashi Tohru; Shimomura Iichiro
Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice.
Cardiovascular research 2009;84(1):164-72.
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2009: Tanaka Ayako; Kaneto Hideaki; Miyatsuka Takeshi; Yamamoto Kaoru; Yoshiuchi Kazutomi; Yamasaki Yoshimitsu; Shimomura Iichiro; Matsuoka Taka-Aki; Matsuhisa Munehide
Role of copper ion in the pathogenesis of type 2 diabetes.
Endocrine journal 2009;56(5):699-706.
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2009: Fukushima Juichi; Kamada Yoshihiro; Matsumoto Hitoshi; Yoshida Yuichi; Ezaki Hisao; Takemura Takayo; Saji Yukiko; Igura Takumi; Tsutsui Shusaku; Kihara Shinji; Funahashi Tohru; Shimomura Iichiro; Tamura Shinji; Kiso Shinichi; Hayashi Norio
Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization.
Hepatology research : the official journal of the Japan Society of Hepatology 2009;39(7):724-38.
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2009: Hibuse Toshiyuki; Maeda Norikazu; Nakatsuji Hideaki; Tochino Yoshihiro; Fujita Koichi; Kihara Shinji; Funahashi Tohru; Shimomura Iichiro
The heart requires glycerol as an energy substrate through aquaporin 7, a glycerol facilitator.
Cardiovascular research 2009;83(1):34-41.
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2009: Koseki Masahiro; Matsuyama Akifumi; Nakatani Kazuhiro; Inagaki Miwako; Nakaoka Hajime; Kawase Ryota; Yuasa-Kawase Miyako; Tsubakio-Yamamoto Kazumi; Masuda Daisaku; Sandoval Jose C; Ohama Tohru; Nakagawa-Toyama Yumiko; Matsuura Fumihiko; Nishida Makoto; Ishigami Masato; Hirano Ken-ichi; Sakane Naoki; Kumon Yoshitaka; Suehiro Tadashi; Nakamura Tadashi; Shimomura Iichiro; Yamashita Shizuya
Impaired insulin secretion in four Tangier disease patients with ABCA1 mutations.
Journal of atherosclerosis and thrombosis 2009;16(3):292-6.
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2009: Kobayashi Hironori; Matsuda Morihiro; Fukuhara Atsunori; Komuro Ryutaro; Shimomura Iichiro
Dysregulated glutathione metabolism links to impaired insulin action in adipocytes.
American journal of physiology. Endocrinology and metabolism 2009;296(6):E1326-34.
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2009: Kita Shunbun; Nishizawa Hitoshi; Okuno Yosuke; Tanaka Masaki; Yasui Atsutaka; Matsuda Morihiro; Yamada Yukio; Shimomura Iichiro
Competitive binding of musclin to natriuretic peptide receptor 3 with atrial natriuretic peptide.
The Journal of endocrinology 2009;201(2):287-95.
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2009: Masuda Daisaku; Hirano Ken-ichi; Oku Hiroyuki; Sandoval Jose C; Kawase Ryota; Yuasa-Kawase Miyako; Yamashita Yasushi; Takada Masanori; Tsubakio-Yamamoto Kazumi; Tochino Yoshihiro; Koseki Masahiro; Matsuura Fumihiko; Nishida Makoto; Kawamoto Toshiharu; Ishigami Masato; Hori Masatsugu; Shimomura Iichiro; Yamashita Shizuya
Chylomicron remnants are increased in the postprandial state in CD36 deficiency.
Journal of lipid research 2009;50(5):999-1011.
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2009: Nakagawa Yasuhiko; Kishida Ken; Kihara Shinji; Funahashi Tohru; Shimomura Iichiro
Adiponectin ameliorates hypoxia-induced pulmonary arterial remodeling.
Biochemical and biophysical research communications 2009;382(1):183-8.
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2009: Oze-Fukai Aya; Fujisawa Tomomi; Sugimoto Ken; Nojima Koji; Shindo Nobuyasu; Shimoyoshi Satomi; Yoshikawa Yuki; Sato Yoshifumi; Shimomura Iichirou; Ikegami Hiroshi; Rakugi Hiromi
A novel mouse model for type 2 diabetes and non-alcoholic fatty liver disease: spontaneous amelioration of diabetes by augmented beta cell mass.
Endocrine journal 2009;56(2):227-34.
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2009: Ebina Kosuke; Fukuhara Atsunori; Ando Wataru; Hirao Makoto; Koga Tadashi; Oshima Kazuya; Matsuda Morihiro; Maeda Kazuhisa; Nakamura Tadashi; Ochi Takahiro; Shimomura Iichiro; Yoshikawa Hideki; Hashimoto Jun
Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction.
Clinical rheumatology 2009;28(4):445-51.
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2009: Tanabe Aya; Matsuda Morihiro; Fukuhara Atsunori; Miyata Yugo; Komuro Ryutaro; Shimomura Iichiro; Tojo Hiromasa
Obesity causes a shift in metabolic flow of gangliosides in adipose tissues.
Biochemical and biophysical research communications 2009;379(2):547-52.
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2009: Nakayama Yuki; Komuro Ryutaro; Yamamoto Akiko; Miyata Yugo; Tanaka Masaki; Matsuda Morihiro; Fukuhara Atsunori; Shimomura Iichiro
RhoA induces expression of inflammatory cytokine in adipocytes.
Biochemical and biophysical research communications 2009;379(2):288-92.
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2009: Ebina Kosuke; Oshima Kazuya; Matsuda Morihiro; Fukuhara Atsunori; Maeda Kazuhisa; Kihara Shinji; Hashimoto Jun; Ochi Takahiro; Banda Nirmal K; Yoshikawa Hideki; Shimomura Iichiro
Adenovirus-mediated gene transfer of adiponectin reduces the severity of collagen-induced arthritis in mice.
Biochemical and biophysical research communications 2009;378(2):186-91.
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2009: Ezaki Hisao; Yoshida Yuichi; Saji Yukiko; Takemura Takayo; Fukushima Juichi; Matsumoto Hitoshi; Kamada Yoshihiro; Wada Akira; Igura Takumi; Kihara Shinji; Funahashi Tohru; Shimomura Iichiro; Tamura Shinji; Kiso Shinichi; Hayashi Norio
Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice.
Biochemical and biophysical research communications 2009;378(1):68-72.
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2009: Segawa Katsumori; Matsuda Morihiro; Fukuhara Atsunori; Morita Kentaro; Okuno Yosuke; Komuro Ryutaro; Shimomura Iichiro
Identification of a novel distal enhancer in human adiponectin gene.
The Journal of endocrinology 2009;200(1):107-16.
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2009: Okauchi Yukiyoshi; Nammo Takao; Iwahashi Hiromi; Kizu Takashi; Hayashi Isao; Okita Kohei; Yamagata Kazuya; Uno Sae; Katsube Fumie; Matsuhisa Munehide; Kato Ken; Aozasa Katsuyuki; Kim Tonsok; Osuga Keigo; Nakamori Shoji; Tamaki Yasuhiro; Funahashi Tohru; Miyagawa Jun-ichiro; Shimomura Iichiro
Glucagonoma diagnosed by arterial stimulation and venous sampling (ASVS).
Internal medicine (Tokyo, Japan) 2009;48(12):1025-30.
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2008: Tokunaga Ayumi; Horikawa Yukio; Fukuda-Akita Etsuko; Okita Kohei; Iwahashi Hiromi; Shimomura Iichiro; Takeda Jun; Yamagata Kazuya
A common P2 promoter polymorphism of the hepatocyte nuclear factor-4alpha gene is associated with insulin secretion in non-obese Japanese with type 2 diabetes.
Endocrine journal 2008;55(6):999-1004.
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2008: Okauchi Yukiyoshi; Iwahashi Hiromi; Okita Kohei; Yuan Ming; Matsuda Morihiro; Tanaka Toshiya; Miyagawa Junichiro; Funahashi Tohru; Horikawa Yukio; Shimomura Iichiro; Yamagata Kazuya
PGC-1alpha Gly482Ser polymorphism is associated with the plasma adiponectin level in type 2 diabetic men.
Endocrine journal 2008;55(6):991-7.
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2008: Nishihara Tamao; Baba Miyako; Matsuda Morihiro; Inoue Masahiro; Nishizawa Yasuko; Fukuhara Atsunori; Araki Hiroshi; Kihara Shinji; Funahashi Tohru; Tamura Shinji; Hayashi Norio; Iishi Hiroyasu; Shimomura Iichiro
Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice.
World journal of gastroenterology : WJG 2008;14(42):6473-80.
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2008: Maeda Norikazu; Funahashi Tohru; Shimomura Iichiro
Metabolic impact of adipose and hepatic glycerol channels aquaporin 7 and aquaporin 9.
Nature clinical practice. Endocrinology & metabolism 2008;4(11):627-34.
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2008: Tsubakio-Yamamoto Kazumi; Matsuura Fumihiko; Koseki Masahiro; Oku Hiroyuki; Sandoval Jose C; Inagaki Miwako; Nakatani Kazuhiro; Nakaoka Hajime; Kawase Ryota; Yuasa-Kawase Miyako; Masuda Daisaku; Ohama Tohru; Maeda Norikazu; Nakagawa-Toyama Yumiko; Ishigami Masato; Nishida Makoto; Kihara Shinji; Shimomura Iichiro; Yamashita Shizuya
Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages.
Biochemical and biophysical research communications 2008;375(3):390-4.
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2008: Araki H; Nishihara T; Matsuda M; Fukuhara A; Kihara S; Funahashi T; Kataoka T R; Kamada Y; Kiyohara T; Tamura S; Hayashi N; Shimomura I
Adiponectin plays a protective role in caerulein-induced acute pancreatitis in mice fed a high-fat diet.
Gut 2008;57(10):1431-40.
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2008: Ebina Kosuke; Fukuhara Atsunori; Shimomura Iichiro
[Role of adipocytokine in bone metabolism]
Clinical calcium 2008;18(5):623-30.
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2008: Abe Manabu; Matsuda Morihiro; Kobayashi Hironori; Miyata Yugo; Nakayama Yuki; Komuro Ryutaro; Fukuhara Atsunori; Shimomura Iichiro
Effects of statins on adipose tissue inflammation: their inhibitory effect on MyD88-independent IRF3/IFN-beta pathway in macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(5):871-7.
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2008: Fujita Koichi; Maeda Norikazu; Sonoda Mina; Ohashi Koji; Hibuse Toshiyuki; Nishizawa Hitoshi; Nishida Makoto; Hiuge Aki; Kurata Akifumi; Kihara Shinji; Shimomura Iichiro; Funahashi Tohru
Adiponectin protects against angiotensin II-induced cardiac fibrosis through activation of PPAR-alpha.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(5):863-70.
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2008: Yamashita Shizuya; Nakamura Mitsuhiro; Koizumi Hiroaki; Oku Hiroyuki; C Sandoval Jose; Tsubakio-Yamamoto Kazumi; Kawase Miyako; Masuda Daisaku; Koseki Masahiro; Matsuura Fumihiko; Shimomura Iichiro; Nishida Makoto; Ishigami Masato
Evaluation of a homogeneous assay for measuring LDL-cholesterol in hyperlipidemic serum specimens.
Journal of atherosclerosis and thrombosis 2008;15(2):82-6.
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2008: Dekker Jacqueline M; Funahashi Tohru; Nijpels Giel; Pilz Stefan; Stehouwer Coen D A; Snijder Marieke B; Bouter Lex M; Matsuzawa Yuji; Shimomura Iichiro; Heine Robert J
Prognostic value of adiponectin for cardiovascular disease and mortality.
The Journal of clinical endocrinology and metabolism 2008;93(4):1489-96.
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2008: Nakagawa Yasuhiko; Kishida Ken; Kihara Shinji; Sonoda Mina; Hirata Ayumu; Yasui Atsutaka; Nishizawa Hitoshi; Nakamura Tadashi; Yoshida Ryoko; Shimomura Iichiro; Funahashi Tohru
Nocturnal reduction in circulating adiponectin concentrations related to hypoxic stress in severe obstructive sleep apnea-hypopnea syndrome.
American journal of physiology. Endocrinology and metabolism 2008;294(4):E778-84.
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2008: Tokunaga Ayumi; Miura Atsuko; Okauchi Yukiyoshi; Segawa Katsumori; Fukuhara Atsunori; Okita Kohei; Takahashi Masahiko; Funahashi Tohru; Miyagawa Jun-Ichiro; Shimomura Iichiro; Yamagata Kazuya
The -1535 promoter variant of the visfatin gene is associated with serum triglyceride and HDL-cholesterol levels in Japanese subjects.
Endocrine journal 2008;55(1):205-12.
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2008: Okada Takuya; Nishizawa Hitoshi; Kurata Akifumi; Tamba Sachiko; Sonoda Mina; Yasui Atsutaka; Kuroda Yohei; Hibuse Toshiyuki; Maeda Norikazu; Kihara Shinji; Hadama Tohru; Tobita Kazuki; Akamatsu Suguru; Maeda Kazuhisa; Shimomura Iichiro; Funahashi Tohru
URB is abundantly expressed in adipose tissue and dysregulated in obesity.
Biochemical and biophysical research communications 2008;367(2):370-6.
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2008: Fukuda-Akita Etsuko; Okita Kohei; Okauchi Yukiyoshi; Ryo Miwa; Nakamura Tadashi; Funahashi Tohru; Iwahashi Hiromi; Shimomura Iichiro; Miyagawa Junichiro; Yamagata Kazuya
Impaired early insulin secretion in Japanese type 2 diabetes with metabolic syndrome.
Diabetes research and clinical practice 2008;79(3):482-9.
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2008: Okuno Yosuke; Matsuda Morihiro; Kobayashi Hironori; Morita Kentaro; Suzuki Emi; Fukuhara Atsunori; Komuro Ryutaro; Shimabukuro Michio; Shimomura Iichiro
Adipose expression of catalase is regulated via a novel remote PPARgamma-responsive region.
Biochemical and biophysical research communications 2008;366(3):698-704.
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2008: Komura Noriyuki; Kihara Shinji; Sonoda Mina; Kumada Masahiro; Fujita Koichi; Hiuge Aki; Okada Takuya; Nakagawa Yasuhiko; Tamba Sachiko; Kuroda Yohei; Hayashi Noriyuki; Sumitsuji Satoru; Kawamoto Toshiharu; Matsumoto Satoru; Ouchi Noriyuki; Arita Yukio; Okamoto Yoshihisa; Shimomura Iichiro; Funahashi Tohru; Matsuzawa Yuji;
Clinical significance of high-molecular weight form of adiponectin in male patients with coronary artery disease.
Circulation journal : official journal of the Japanese Circulation Society 2008;72(1):23-8.
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2008: Miyata Yugo; Fukuhara Atsunori; Matsuda Morihiro; Komuro Ryutaro; Shimomura Iichiro
Insulin induces chaperone and CHOP gene expressions in adipocytes.
Biochemical and biophysical research communications 2008;365(4):826-32.
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2008: Nammo Takao; Yamagata Kazuya; Tanaka Toshiya; Kodama Tatsuhiko; Sladek Frances M; Fukui Kenji; Katsube Fumie; Sato Yoshifumi; Miyagawa Jun-Ichiro; Shimomura Iichiro
Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas.
Gene expression patterns : GEP 2008;8(2):96-106.
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2008: Fujisawa Tomomi; Ikegami Hiroshi; Kasayama Soji; Matsuhisa Munehide; Yamasaki Yoshimitsu; Miyagawa Jun-ichiro; Funahashi Tohru; Shimomura Iichiro
Age-dependent difference in factors affecting choice of system for self-monitoring of blood glucose.
Diabetes research and clinical practice 2008;79(1):103-7.
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2008: Takagi Toshiyuki; Matsuda Morihiro; Abe Manabu; Kobayashi Hironori; Fukuhara Atsunori; Komuro Ryutaro; Kihara Shinji; Caslake Muriel J; McMahon Alex; Shepherd James; Funahashi Tohru; Shimomura Iichiro
Effect of pravastatin on the development of diabetes and adiponectin production.
Atherosclerosis 2008;196(1):114-21.
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2008: Lim Soo; Koo Bo Kyeong; Cho Sun Wook; Kihara Shinji; Funahashi Tohru; Cho Young Min; Kim Seong Yeon; Lee Hong Kyu; Shimomura Iichiro; Park Kyong Soo
Association of adiponectin and resistin with cardiovascular events in Korean patients with type 2 diabetes: the Korean atherosclerosis study (KAS): a 42-month prospective study.
Atherosclerosis 2008;196(1):398-404.
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2008: Tamba Sachiko; Nishizawa Hitoshi; Funahashi Tohru; Okauchi Yukiyoshi; Ogawa Tomoko; Noguchi Midori; Fujita Koichi; Ryo Miwa; Kihara Shinji; Iwahashi Hiromi; Yamagata Kazuya; Nakamura Tadashi; Shimomura Iichiro; Matsuzawa Yuji
Relationship between the serum uric acid level, visceral fat accumulation and serum adiponectin concentration in Japanese men.
Internal medicine (Tokyo, Japan) 2008;47(13):1175-80.
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2007: Yasui Atsutaka; Nishizawa Hitoshi; Okuno Yosuke; Morita Kentaro; Kobayashi Hironori; Kawai Kenichiro; Matsuda Morihiro; Kishida Ken; Kihara Shinji; Kamei Yasutomi; Ogawa Yoshihiro; Funahashi Tohru; Shimomura Iichiro
Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor.
Biochemical and biophysical research communications 2007;364(2):358-65.
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2007: Nozaki Maiko; Fukuhara Atsunori; Segawa Katsumori; Okuno Yosuke; Abe Manabu; Hosogai Naomi; Matsuda Morihiro; Komuro Ryutaro; Shimomura Iichiro
Nitric oxide dysregulates adipocytokine expression in 3T3-L1 adipocytes.
Biochemical and biophysical research communications 2007;364(1):33-9.
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2007: Fukuhara Atsunori; Matsuda Morihiro; Nishizawa Masako; Segawa Katsumori; Tanaka Masaki; Kishimoto Kae; Matsuki Yasushi; Murakami Mirei; Ichisaka Tomoko; Murakami Hiroko; Watanabe Eijiro; Takagi Toshiyuki; Akiyoshi Megumi; Ohtsubo Tsuguteru; Kihara Shinji; Yamashita Shizuya; Makishima Makoto; Funahashi Tohru; Yamanaka Shinya; Hiramatsu Ryuji; Matsuzawa Yuji; Shimomura Iichiro
Retraction.
Science (New York, N.Y.) 2007;318(5850):565.
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2007: Oku Hiroyuki; Matsuura Fumihiko; Koseki Masahiro; Sandoval Jose C; Yuasa-Kawase Miyako; Tsubakio-Yamamoto Kazumi; Masuda Daisaku; Maeda Norikazu; Ohama Tohru; Ishigami Masato; Nishida Makoto; Hirano Ken-ichi; Kihara Shinji; Hori Masatsugu; Shimomura Iichiro; Yamashita Shizuya
Adiponectin deficiency suppresses ABCA1 expression and ApoA-I synthesis in the liver.
FEBS letters 2007;581(26):5029-33.
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2007: Kamada Yoshihiro; Matsumoto Hitoshi; Tamura Shinji; Fukushima Juichi; Kiso Shinichi; Fukui Koji; Igura Takumi; Maeda Norikazu; Kihara Shinji; Funahashi Tohru; Matsuzawa Yuji; Shimomura Iichiro; Hayashi Norio
Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model.
Journal of hepatology 2007;47(4):556-64.
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2007: Sugiyama Seigo; Fukushima Hironobu; Kugiyama Kiyotaka; Maruyoshi Hidetomo; Kojima Sunao; Funahashi Tohru; Sakamoto Tomohiro; Horibata Yoko; Watanabe Keisuke; Koga Hidenobu; Sugamura Koichi; Otsuka Fumiyuki; Shimomura Iichirou; Ogawa Hisao
Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease.
Atherosclerosis 2007;194(2):e43-51.
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2007: Zhang J; Tokui Y; Yamagata K; Kozawa J; Sayama K; Iwahashi H; Okita K; Miuchi M; Konya H; Hamaguchi T; Namba M; Shimomura I; Miyagawa J-i
Continuous stimulation of human glucagon-like peptide-1 (7-36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes.
Diabetologia 2007;50(9):1900-9.
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2007: Ohashi Koji; Iwatani Hirotsugu; Kihara Shinji; Nakagawa Yasuhiko; Komura Noriyuki; Fujita Koichi; Maeda Norikazu; Nishida Makoto; Katsube Fumie; Shimomura Iichiro; Ito Takahito; Funahashi Tohru
Exacerbation of albuminuria and renal fibrosis in subtotal renal ablation model of adiponectin-knockout mice.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(9):1910-7.
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2007: Okauchi Yukiyoshi; Nishizawa Hitoshi; Funahashi Tohru; Ogawa Tomoko; Noguchi Midori; Ryo Miwa; Kihara Shinji; Iwahashi Hiromi; Yamagata Kazuya; Nakamura Tadashi; Shimomura Iichiro; Matsuzawa Yuji
Reduction of visceral fat is associated with decrease in the number of metabolic risk factors in Japanese men.
Diabetes care 2007;30(9):2392-4.
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2007: Tanaka Masaki; Nozaki Maiko; Fukuhara Atsunori; Segawa Katsumori; Aoki Naohito; Matsuda Morihiro; Komuro Ryutaro; Shimomura Iichiro
Visfatin is released from 3T3-L1 adipocytes via a non-classical pathway.
Biochemical and biophysical research communications 2007;359(2):194-201.
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2007: Matsuura Fumihiko; Oku Hiroyuki; Koseki Masahiro; Sandoval Jose C; Yuasa-Kawase Miyako; Tsubakio-Yamamoto Kazumi; Masuda Daisaku; Maeda Norikazu; Tsujii Ken-ichi; Ishigami Masato; Nishida Makoto; Hirano Ken-ichi; Kihara Shinji; Hori Masatsugu; Shimomura Iichiro; Yamashita Shizuya
Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver.
Biochemical and biophysical research communications 2007;358(4):1091-5.
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2007: Nishida Makoto; Funahashi Tohru; Shimomura Iichiro
Pathophysiological significance of adiponectin.
Medical molecular morphology 2007;40(2):55-67.
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2007: Matsuura Fumihiko; Hirano Ken-Ichi; Ikegami Chiaki; Sandoval Jose C; Oku Hiroyuki; Yuasa-Kawase Miyako; Tsubakio-Yamamoto Kazumi; Koseki Masahiro; Masuda Daisaku; Tsujii Ken-Ichi; Ishigami Masato; Nishida Makoto; Shimomura Iichiro; Hori Masatsugu; Yamashita Shizuya
Senescent phenotypes of skin fibroblasts from patients with Tangier disease.
Biochemical and biophysical research communications 2007;357(2):493-8.
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2007: Hosogai Naomi; Fukuhara Atsunori; Oshima Kazuya; Miyata Yugo; Tanaka Sachiyo; Segawa Katsumori; Furukawa Shigetada; Tochino Yoshihiro; Komuro Ryutaro; Matsuda Morihiro; Shimomura Iichiro
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation.
Diabetes 2007;56(4):901-11.
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2007: Tanida Mamoru; Shen Jiao; Horii Yuko; Matsuda Morihiro; Kihara Shinji; Funahashi Toru; Shimomura Iichiro; Sawai Hajime; Fukuda Yutaka; Matsuzawa Yuji; Nagai Katsuya
Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats.
Experimental biology and medicine (Maywood, N.J.) 2007;232(3):390-7.
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2007: Uno S; Imagawa A; Okita K; Sayama K; Moriwaki M; Iwahashi H; Yamagata K; Tamura S; Matsuzawa Y; Hanafusa T; Miyagawa J; Shimomura I
Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor-alpha in patients with recent-onset type 1 diabetes.
Diabetologia 2007;50(3):596-601.
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2007: Hiuge Aki; Tenenbaum Alexander; Maeda Norikazu; Benderly Michal; Kumada Masahiro; Fisman Enrique Z; Tanne David; Matas Zipora; Hibuse Toshiyuki; Fujita Koichi; Nishizawa Hitoshi; Adler Yehuda; Motro Michael; Kihara Shinji; Shimomura Iichiro; Behar Solomon; Funahashi Tohru
Effects of peroxisome proliferator-activated receptor ligands, bezafibrate and fenofibrate, on adiponectin level.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(3):635-41.
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2007: Shimamura Mitsuru; Matsuda Morihiro; Yasumo Hiroaki; Okazaki Mitsuyo; Fujimoto Kazunori; Kono Keita; Shimizugawa Tetsuya; Ando Yosuke; Koishi Ryuta; Kohama Takafumi; Sakai Naohiko; Kotani Kazuaki; Komuro Ryutaro; Ishida Tatsuo; Hirata Kenichi; Yamashita Shizuya; Furukawa Hidehiko; Shimomura Iichiro
Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(2):366-72.
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2007: Koseki Masahiro; Hirano Ken-Ichi; Masuda Daisaku; Ikegami Chiaki; Tanaka Masaki; Ota Akemi; Sandoval Jose C; Nakagawa-Toyama Yumiko; Sato Satoshi B; Kobayashi Toshihide; Shimada Yukiko; Ohno-Iwashita Yoshiko; Matsuura Fumihiko; Shimomura Iichiro; Yamashita Shizuya
Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor-alpha secretion in Abca1-deficient macrophages.
Journal of lipid research 2007;48(2):299-306.
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2007: Nakamura Tadashi; Okauchi Yukiyoshi; Ryo Miwa; Funahashi Tohru; Shimomura Iichiro
Clinical diagnosis of metabolic syndrome 3. Diagnostic criteria for metabolic syndrome in Japan and its clinical significance.
Internal medicine (Tokyo, Japan) 2007;46(16):1287.
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2007: Kishida Ken; Nakaoka Hajime; Sumitsuji Satoru; Nakatsuji Hideaki; Ihara Madoka; Nojima Yuhei; Shimomura Iichiro; Nagai Yoshiyuki
Successful surgical treatment of an infected right coronary artery aneurysm-to-right ventricle fistula after sirolimus-eluting stent implantation.
Internal medicine (Tokyo, Japan) 2007;46(12):865-71.
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2006: Tokui Yae; Kozawa Junji; Yamagata Kazuya; Zhang Jun; Ohmoto Hiroshi; Tochino Yoshihiro; Okita Kohei; Iwahashi Hiromi; Namba Mitsuyoshi; Shimomura Iichiro; Miyagawa Jun-ichiro
Neogenesis and proliferation of beta-cells induced by human betacellulin gene transduction via retrograde pancreatic duct injection of an adenovirus vector.
Biochemical and biophysical research communications 2006;350(4):987-93.
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2006: Kadowaki Kozo; Waguri Masako; Nakanishi Isao; Miyashita Yoshihiro; Nakayama Masahiro; Suehara Noriyuki; Funahashi Tohru; Shimomura Iichiro; Fujita Tomio
Adiponectin concentration in umbilical cord serum is positively associated with the weight ratio of fetus to placenta.
The Journal of clinical endocrinology and metabolism 2006;91(12):5090-4.
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2006: Shimomura Iichiro; Maeda Kazuhisa; Nakamura Tadashi; Funabashi Tetsu
[Metabolic syndrome and adiponectin]
Masui. The Japanese journal of anesthesiology 2006;55 Suppl():S11-7.
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2006: Snijder Marieke B; Heine Robert J; Seidell Jacob C; Bouter Lex M; Stehouwer Coen D A; Nijpels Giel; Funahashi Tohru; Matsuzawa Yuji; Shimomura Iichiro; Dekker Jacqueline M
Associations of adiponectin levels with incident impaired glucose metabolism and type 2 diabetes in older men and women: the hoorn study.
Diabetes care 2006;29(11):2498-503.
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2006: Fujita Koichi; Nishizawa Hitoshi; Funahashi Tohru; Shimomura Iichiro; Shimabukuro Michio
Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome.
Circulation journal : official journal of the Japanese Circulation Society 2006;70(11):1437-42.
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2006: Kurata A; Nishizawa H; Kihara S; Maeda N; Sonoda M; Okada T; Ohashi K; Hibuse T; Fujita K; Yasui A; Hiuge A; Kumada M; Kuriyama H; Shimomura I; Funahashi T
Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation.
Kidney international 2006;70(10):1717-24.
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2006: Segawa Katsumori; Fukuhara Atsunori; Hosogai Naomi; Morita Kentaro; Okuno Yosuke; Tanaka Masaki; Nakagawa Yasuhiko; Kihara Shinji; Funahashi Tohru; Komuro Ryutaro; Matsuda Morihiro; Shimomura Iichiro
Visfatin in adipocytes is upregulated by hypoxia through HIF1alpha-dependent mechanism.
Biochemical and biophysical research communications 2006;349(3):875-82.
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2006: Fukui Koji; Tamura Shinji; Wada Akira; Kamada Yoshihiro; Sawai Yoshiyuki; Imanaka Kazuho; Kudara Takahiko; Shimomura Iichiro; Hayashi Norio
Expression and prognostic role of RhoA GTPases in hepatocellular carcinoma.
Journal of cancer research and clinical oncology 2006;132(10):627-33.
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2006: Nakamura Tadashi; Okauchi Yukiyoshi; Ryo Miwa; Funahashi Toru; Shimomura Iichiro
[Diagnosis of metabolic syndrome]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2006;95(9):1731-6.
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2006: Nishihara Tamao; Matsuda Morihiro; Araki Hiroshi; Oshima Kazuya; Kihara Shinji; Funahashi Tohru; Shimomura Iichiro
Effect of adiponectin on murine colitis induced by dextran sulfate sodium.
Gastroenterology 2006;131(3):853-61.
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2006: Oshima Kazuya; Shimomura Iichiro; Iwahashi Hiromi
[The effects of visceral fat accumulation by diabetes mellitus on bone metabolism]
Clinical calcium 2006;16(8):1332-42.
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2006: Matsumoto Hitoshi; Tamura Shinji; Kamada Yoshihiro; Kiso Shinichi; Fukushima Juichi; Wada Akira; Maeda Norikazu; Kihara Shinji; Funahashi Tohru; Matsuzawa Yuji; Shimomura Iichiro; Hayashi Norio
Adiponectin deficiency exacerbates lipopolysaccharide/D-galactosamine-induced liver injury in mice.
World journal of gastroenterology : WJG 2006;12(21):3352-8.
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2006: Ohashi Koji; Kihara Shinji; Ouchi Noriyuki; Kumada Masahiro; Fujita Koichi; Hiuge Aki; Hibuse Toshiyuki; Ryo Miwa; Nishizawa Hitoshi; Maeda Norikazu; Maeda Kazuhisa; Shibata Rei; Walsh Kenneth; Funahashi Tohru; Shimomura Iichiro
Adiponectin replenishment ameliorates obesity-related hypertension.
Hypertension 2006;47(6):1108-16.
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2006: Miyoshi Yasuo; Funahashi Tohru; Tanaka Sachiyo; Taguchi Tetsuya; Tamaki Yasuhiro; Shimomura Iichiro; Noguchi Shinzaburo
High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels.
International journal of cancer. Journal international du cancer 2006;118(6):1414-9.
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2006: Miura Atsuko; Yamagata Kazuya; Kakei Masafumi; Hatakeyama Hiroyasu; Takahashi Noriko; Fukui Kenji; Nammo Takao; Yoneda Kazue; Inoue Yusuke; Sladek Frances M; Magnuson Mark A; Kasai Haruo; Miyagawa Junichiro; Gonzalez Frank J; Shimomura Iichiro
Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.
The Journal of biological chemistry 2006;281(8):5246-57.
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2006: Wada Akira; Fukui Koji; Sawai Yoshiyuki; Imanaka Kazuho; Kiso Shinichi; Tamura Shinji; Shimomura Iichiro; Hayashi Norio
Pamidronate induced anti-proliferative, apoptotic, and anti-migratory effects in hepatocellular carcinoma.
Journal of hepatology 2006;44(1):142-50.
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2006: Kato Hisashi; Kashiwagi Hirokazu; Shiraga Masamichi; Tadokoro Seiji; Kamae Tsuyoshi; Ujiie Hidetoshi; Honda Shigenori; Miyata Shigeki; Ijiri Yoshinobu; Yamamoto Junichiro; Maeda Norikazu; Funahashi Tohru; Kurata Yoshiyuki; Shimomura Iichiro; Tomiyama Yoshiaki; Kanakura Yuzuru
Adiponectin acts as an endogenous antithrombotic factor.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(1):224-30.
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2005: Fukui Kenji; Yang Qin; Cao Yang; Takahashi Noriko; Hatakeyama Hiroyasu; Wang Haiyan; Wada Jun; Zhang Yanling; Marselli Lorella; Nammo Takao; Yoneda Kazue; Onishi Mineki; Higashiyama Shigeki; Matsuzawa Yuji; Gonzalez Frank J; Weir Gordon C; Kasai Haruo; Shimomura Iichiro; Miyagawa Jun-ichiro; Wollheim Claes B; Yamagata Kazuya
The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation.
Cell metabolism 2005;2(6):373-84.
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2005: Morita Kentaro; Kawana Katsuyoshi; Sodeyama Mariko; Shimomura Iichiro; Kagechika Hiroyuki; Makishima Makoto
Selective allosteric ligand activation of the retinoid X receptor heterodimers of NGFI-B and Nurr1.
Biochemical pharmacology 2005;71(1-2):98-107.
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2005: Nakano Hiroyuki; Matsunawa Manabu; Yasui Atsutaka; Adachi Ryutaro; Kawana Katsuyoshi; Shimomura Iichiro; Makishima Makoto
Enhancement of ligand-dependent vitamin D receptor transactivation by the cardiotonic steroid bufalin.
Biochemical pharmacology 2005;70(10):1479-86.
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2005: Hirano Ken-ichi; Ikegami Chiaki; Tsujii Ken-ichi; Zhang Zhongyan; Matsuura Fumihiko; Nakagawa-Toyama Yumiko; Koseki Masahiro; Masuda Daisaku; Maruyama Takao; Shimomura Iichiro; Ueda Yukihiko; Yamashita Shizuya
Probucol enhances the expression of human hepatic scavenger receptor class B type I, possibly through a species-specific mechanism.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(11):2422-7.
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2005: Shimomura Iichiro
[Research in internal medicine--possibilities for its approach]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2005;94(9):1889-92.
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2005: Maruyoshi Hidetomo; Kojima Sunao; Otsuka Fumiyuki; Funahashi Tohru; Kaikita Koichi; Sugiyama Seigo; Sakamoto Tomohiro; Yoshimura Michihiro; Shimomura Iichiro; Ogawa Hisao
Hypoadiponectinemia is associated with coronary artery spasm in men.
Circulation journal : official journal of the Japanese Circulation Society 2005;69(9):1154-6.
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2005: Kurosu Hiroshi; Yamamoto Masaya; Clark Jeremy D; Pastor Johanne V; Nandi Animesh; Gurnani Prem; McGuinness Owen P; Chikuda Hirotaka; Yamaguchi Masayuki; Kawaguchi Hiroshi; Shimomura Iichiro; Takayama Yoshiharu; Herz Joachim; Kahn C Ronald; Rosenblatt Kevin P; Kuro-o Makoto
Suppression of aging in mice by the hormone Klotho.
Science (New York, N.Y.) 2005;309(5742):1829-33.
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2005: Liao Yulin; Takashima Seiji; Maeda Norikazu; Ouchi Noriyuki; Komamura Kazuo; Shimomura Iichiro; Hori Masatsugu; Matsuzawa Yuji; Funahashi Tohru; Kitakaze Masafumi
Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism.
Cardiovascular research 2005;67(4):705-13.
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2005: Hibuse Toshiyuki; Maeda Norikazu; Funahashi Tohru; Yamamoto Kaori; Nagasawa Azumi; Mizunoya Wataru; Kishida Ken; Inoue Kazuo; Kuriyama Hiroshi; Nakamura Tadashi; Fushiki Tohru; Kihara Shinji; Shimomura Iichiro
Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):10993-8.
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2005: Sayama K; Imagawa A; Okita K; Uno S; Moriwaki M; Kozawa J; Iwahashi H; Yamagata K; Tamura S; Matsuzawa Y; Hanafusa T; Miyagawa J; Shimomura I
Pancreatic beta and alpha cells are both decreased in patients with fulminant type 1 diabetes: a morphometrical assessment.
Diabetologia 2005;48(8):1560-4.
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2005: Kozawa Junji; Tokui Yae; Moriwaki Makoto; Li Ming; Ohmoto Hiroshi; Yuan Ming; Zhang Jun; Iwahashi Hiromi; Imagawa Akihisa; Yamagata Kazuya; Tochino Yoshihiro; Shimomura Iichiro; Higashiyama Shigeki; Miyagawa Jun-ichiro
Regenerative and therapeutic effects of heparin-binding epidermal growth factor-like growth factor on diabetes by gene transduction through retrograde pancreatic duct injection of adenovirus vector.
Pancreas 2005;31(1):32-42.
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2005: Komazawa N; Matsuda M; Kondoh G; Mizunoya W; Iwaki M; Takagi T; Sumikawa Y; Inoue K; Suzuki A; Mak T W; Nakano T; Fushiki T; Takeda J; Shimomura I
Retraction: Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice.
Nature medicine 2005;11(6):690.
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2005: Yamamoto K; Kiyohara T; Murayama Y; Kihara S; Okamoto Y; Funahashi T; Ito T; Nezu R; Tsutsui S; Miyagawa J-I; Tamura S; Matsuzawa Y; Shimomura I; Shinomura Y
Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease.
Gut 2005;54(6):789-96.
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2005: Oshima Kazuya; Nampei Akihide; Matsuda Morihiro; Iwaki Masanori; Fukuhara Atsunori; Hashimoto Jun; Yoshikawa Hideki; Shimomura Iichiro
Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast.
Biochemical and biophysical research communications 2005;331(2):520-6.
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2005: Fukuen Shuichi; Iwaki Masanori; Yasui Atsutaka; Makishima Makoto; Matsuda Morihiro; Shimomura Iichiro
Sulfonylurea agents exhibit peroxisome proliferator-activated receptor gamma agonistic activity.
The Journal of biological chemistry 2005;280(25):23653-9.
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2005: Kishida Osamu; Miyazaki Yoshiji; Murayama Yoko; Ogasa Miyuki; Miyazaki Tamana; Yamamoto Takahiro; Watabe Kenji; Tsutsui Shusaku; Kiyohara Tatsuya; Shimomura Iichiro; Shinomura Yasuhisa
Gefitinib (Iressa, ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells.
Cancer chemotherapy and pharmacology 2005;55(6):584-94.
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2005: Tamura Shinji; Shimomura Iichiro
Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease.
The Journal of clinical investigation 2005;115(5):1139-42.
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2005: Zhang Zhongyan; Hirano Ken-ichi; Tsukamoto Kosuke; Ikegami Chiaki; Koseki Masahiro; Saijo Kaoru; Ohno Tadao; Sakai Naohiko; Hiraoka Hisatoyo; Shimomura Iichiro; Yamashita Shizuya
Defective cholesterol efflux in Werner syndrome fibroblasts and its phenotypic correction by Cdc42, a RhoGTPase.
Experimental gerontology 2005;40(4):286-94.
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2005: Ihara Arisa; Yamagata Kazuya; Nammo Takao; Miura Atsuko; Yuan Ming; Tanaka Toshiya; Sladek Frances M; Matsuzawa Yuji; Miyagawa Jun-ichiro; Shimomura Iichiro
Functional characterization of the HNF4alpha isoform (HNF4alpha8) expressed in pancreatic beta-cells.
Biochemical and biophysical research communications 2005;329(3):984-90.
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2005: Kishida Osamu; Miyazaki Yoshiji; Murayama Yoko; Ogasa Miyuki; Miyazaki Tamana; Yamamoto Takahiro; Watabe Kenji; Tsutsui Shusaku; Kiyohara Tatsuya; Shimomura Iichiro; Shinomura Yasuhisa
Gefitinib ("Iressa", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells.
Cancer chemotherapy and pharmacology 2005;55(4):393-403.
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2005: Fujita Takuya; Furukawa Shigetada; Morita Kentaro; Ishihara Tomomi; Shiotani Masaharu; Matsushita Yasuaki; Matsuda Morihiro; Shimomura Iichiro
Glucosamine induces lipid accumulation and adipogenic change in C2C12 myoblasts.
Biochemical and biophysical research communications 2005;328(2):369-74.
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2005: Shimomura Iichiro; Kondo Hidehiko
[I164T polymorphism of adiponectin gene in diabetes]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 2():176-9.
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2005: Fukuhara Atsunori; Shimomura Iichiro
[Impaired glucose-uptake in adipocytes]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 2():141-6.
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2005: Ryo Miwa; Maeda Kazuhisa; Onda Tomohiro; Katashima Mitsuhiro; Okumiya Akiko; Nishida Makoto; Yamaguchi Tohru; Funahashi Tohru; Matsuzawa Yuji; Nakamura Tadashi; Shimomura Iichiro
A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance.
Diabetes care 2005;28(2):451-3.
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2005: Fukuhara Atsunori; Matsuda Morihiro; Nishizawa Masako; Segawa Katsumori; Tanaka Masaki; Kishimoto Kae; Matsuki Yasushi; Murakami Mirei; Ichisaka Tomoko; Murakami Hiroko; Watanabe Eijiro; Takagi Toshiyuki; Akiyoshi Megumi; Ohtsubo Tsuguteru; Kihara Shinji; Yamashita Shizuya; Makishima Makoto; Funahashi Tohru; Yamanaka Shinya; Hiramatsu Ryuji; Matsuzawa Yuji; Shimomura Iichiro
Visfatin: a protein secreted by visceral fat that mimics the effects of insulin.
Science (New York, N.Y.) 2005;307(5708):426-30.
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2005: Adachi Ryutaro; Honma Yoshio; Masuno Hiroyuki; Kawana Katsuyoshi; Shimomura Iichiro; Yamada Sachiko; Makishima Makoto
Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative.
Journal of lipid research 2005;46(1):46-57.
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2004: Furukawa Shigetada; Fujita Takuya; Shimabukuro Michio; Iwaki Masanori; Yamada Yukio; Nakajima Yoshimitsu; Nakayama Osamu; Makishima Makoto; Matsuda Morihiro; Shimomura Iichiro
Increased oxidative stress in obesity and its impact on metabolic syndrome.
The Journal of clinical investigation 2004;114(12):1752-61.
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2004: Maeda Norikazu; Funahashi Tohru; Hibuse Toshiyuki; Nagasawa Azumi; Kishida Ken; Kuriyama Hiroshi; Nakamura Tadashi; Kihara Shinji; Shimomura Iichiro; Matsuzawa Yuji
Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(51):17801-6.
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2004: Komazawa Nobuyasu; Matsuda Morihiro; Kondoh Gen; Mizunoya Wataru; Iwaki Masanori; Takagi Toshiyuki; Sumikawa Yasuyuki; Inoue Kazuo; Suzuki Akira; Mak Tak Wah; Nakano Toru; Fushiki Tohru; Takeda Junji; Shimomura Iichiro
Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice.
Nature medicine 2004;10(11):1208-15.
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2004: Kitazawa Hidefumi; Nishihara Tamao; Nambu Tadahiro; Nishizawa Hitoshi; Iwaki Masanori; Fukuhara Atsunori; Kitamura Toshio; Matsuda Morihiro; Shimomura Iichiro
Intectin, a novel small intestine-specific glycosylphosphatidylinositol-anchored protein, accelerates apoptosis of intestinal epithelial cells.
The Journal of biological chemistry 2004;279(41):42867-74.
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2004: Shimamura Mitsuru; Matsuda Morihiro; Ando Yosuke; Koishi Ryuta; Yasumo Hiroaki; Furukawa Hidehiko; Shimomura Iichiro
Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor.
Biochemical and biophysical research communications 2004;322(3):1080-5.
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2004: Matsuda Morihiro; Shimomura Iichiro
[Adipocytokines and metabolic syndrome--molecular mechanism and clinical implication]
Nippon rinsho. Japanese journal of clinical medicine 2004;62(6):1085-90.
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2004: Nishizawa Hitoshi; Matsuda Morihiro; Yamada Yukio; Kawai Kenichiro; Suzuki Emi; Makishima Makoto; Kitamura Toshio; Shimomura Iichiro
Musclin, a novel skeletal muscle-derived secretory factor.
The Journal of biological chemistry 2004;279(19):19391-5.
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2004: Shimomura Iichiro; Funahashi Tooru; Matsuzawa Yuji
[The mechanism and physiopathology of metabolic syndrome. The role of obesity--abnormal production of adipocytokines]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2004;93(4):655-61.
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2004: Matsuzawa Yuji; Funahashi Tohru; Kihara Shinji; Shimomura Iichiro
Adiponectin and metabolic syndrome.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(1):29-33.
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2004: Adachi Ryutaro; Shulman Andrew I; Yamamoto Keiko; Shimomura Iichiro; Yamada Sachiko; Mangelsdorf David J; Makishima Makoto
Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals.
Molecular endocrinology (Baltimore, Md.) 2004;18(1):43-52.
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2003: Shimomura Iichiro
[Adipocytokines and life style-related disease]
Rinsho byori. The Japanese journal of clinical pathology 2003;51(11):1090-5.
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2003: Chen Hui; Montagnani Monica; Funahashi Tohru; Shimomura Iichiro; Quon Michael J
Adiponectin stimulates production of nitric oxide in vascular endothelial cells.
The Journal of biological chemistry 2003;278(45):45021-6.
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2003: Iwahashi H; Funahashi T; Kurokawa N; Sayama K; Fukuda E; Okita K; Imagawa A; Yamagata K; Shimomura I; Miyagawa J-I; Matsuzawa Y
Plasma adiponectin levels in women with anorexia nervosa.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(9):537-40.
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2003: Masaki Takayuki; Chiba Seiichi; Yasuda Tohru; Tsubone Tetsuo; Kakuma Tetsuya; Shimomura Iichiro; Funahashi Tohru; Matsuzawa Yuji; Yoshimatsu Hironobu
Peripheral, but not central, administration of adiponectin reduces visceral adiposity and upregulates the expression of uncoupling protein in agouti yellow (Ay/a) obese mice.
Diabetes 2003;52(9):2266-73.
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2003: Horton Jay D; Shimomura Iichiro; Ikemoto Shinji; Bashmakov Yuriy; Hammer Robert E
Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.
The Journal of biological chemistry 2003;278(38):36652-60.
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2003: Kaneko Emi; Matsuda Morihiro; Yamada Yukio; Tachibana Yoji; Shimomura Iichiro; Makishima Makoto
Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist.
The Journal of biological chemistry 2003;278(38):36091-8.
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2003: Shimabukuro Michio; Higa Namio; Asahi Tomohiro; Oshiro Yoshito; Takasu Nobuyuki; Tagawa Tatsuya; Ueda Shinichiro; Shimomura Iichiro; Funahashi Tohru; Matsuzawa Yuji
Hypoadiponectinemia is closely linked to endothelial dysfunction in man.
The Journal of clinical endocrinology and metabolism 2003;88(7):3236-40.
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2003: Iwaki Masanori; Matsuda Morihiro; Maeda Norikazu; Funahashi Tohru; Matsuzawa Yuji; Makishima Makoto; Shimomura Iichiro
Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors.
Diabetes 2003;52(7):1655-63.
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2003: Vigouroux Corinne; Maachi Mustapha; Nguyên Thu-Huyen; Coussieu Christiane; Gharakhanian Shahin; Funahashi Tohru; Matsuzawa Yuji; Shimomura Iichiro; Rozenbaum Willy; Capeau Jacqueline; Bastard Jean-Philippe
Serum adipocytokines are related to lipodystrophy and metabolic disorders in HIV-infected men under antiretroviral therapy.
AIDS (London, England) 2003;17(10):1503-11.
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2003: Inaba Toshimori; Matsuda Morihiro; Shimamura Mitsuru; Takei Norihide; Terasaka Naoki; Ando Yosuke; Yasumo Hiroaki; Koishi Ryuta; Makishima Makoto; Shimomura Iichiro
Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor.
The Journal of biological chemistry 2003;278(24):21344-51.
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2003: Shimomura Iichiro; Funabashi Tooru; Matsuzawa Yuji
[Current topics in endocrinology: adipocytokines]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2003;92(4):609-15.
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2003: Shimamura Mitsuru; Matsuda Morihiro; Kobayashi Sachiko; Ando Yosuke; Ono Mitsuru; Koishi Ryuta; Furukawa Hidehiko; Makishima Makoto; Shimomura Iichiro
Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes.
Biochemical and biophysical research communications 2003;301(2):604-9.
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2003: Kumada Masahiro; Kihara Shinji; Sumitsuji Satoru; Kawamoto Toshiharu; Matsumoto Satoru; Ouchi Noriyuki; Arita Yukio; Okamoto Yoshihisa; Shimomura Iichiro; Hiraoka Hisatoyo; Nakamura Tadashi; Funahashi Tohru; Matsuzawa Yuji;
Association of hypoadiponectinemia with coronary artery disease in men.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(1):85-9.
-
2003: Matsuzawa Yuji; Shimomura Iichiro; Kihara Shinji; Funahashi Tohru
Importance of adipocytokines in obesity-related diseases.
Hormone research 2003;60 Suppl 3():56-9.
-
2002: Nagasawa A; Fukui K; Funahashi T; Maeda N; Shimomura I; Kihara S; Waki M; Takamatsu K; Matsuzawa Y
Effects of soy protein diet on the expression of adipose genes and plasma adiponectin.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(11-12):635-9.
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2002: Okamoto Yoshihisa; Kihara Shinji; Ouchi Noriyuki; Nishida Makoto; Arita Yukio; Kumada Masahiro; Ohashi Koji; Sakai Naohiko; Shimomura Iichiro; Kobayashi Hideki; Terasaka Naoki; Inaba Toshimori; Funahashi Tohru; Matsuzawa Yuji
Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice.
Circulation 2002;106(22):2767-70.
-
2002: Shimomura Iichiro; Funahashi Tohru; Matsuzawa Yuji
[Significance of adipocytokine, fat-derived hormones, in metabolic syndrome]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2002;47(14):1896-903.
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2002: Kuriyama Hiroshi; Shimomura Iichiro; Kishida Ken; Kondo Hidehiko; Furuyama Naoki; Nishizawa Hitoshi; Maeda Norikazu; Matsuda Morihiro; Nagaretani Hiroyuki; Kihara Shinji; Nakamura Tadashi; Tochino Yoshihiro; Funahashi Tohru; Matsuzawa Yuji
Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9.
Diabetes 2002;51(10):2915-21.
-
2002: Matsuda Morihiro; Shimomura Iichiro; Sata Masataka; Arita Yukio; Nishida Makoto; Maeda Norikazu; Kumada Masahiro; Okamoto Yoshihisa; Nagaretani Hiroyuki; Nishizawa Hitoshi; Kishida Ken; Komuro Ryutaro; Ouchi Noriyuki; Kihara Shinji; Nagai Ryozo; Funahashi Tohru; Matsuzawa Yuji
Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis.
The Journal of biological chemistry 2002;277(40):37487-91.
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2002: Nishizawa Hitoshi; Shimomura Iichiro; Kishida Ken; Maeda Norikazu; Kuriyama Hiroshi; Nagaretani Hiroyuki; Matsuda Morihiro; Kondo Hidehiko; Furuyama Naoki; Kihara Shinji; Nakamura Tadashi; Tochino Yoshihiro; Funahashi Tohru; Matsuzawa Yuji
Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein.
Diabetes 2002;51(9):2734-41.
-
2002: Kondo Hidehiko; Shimomura Iichiro; Matsukawa Yuko; Kumada Masahiro; Takahashi Masahiko; Matsuda Morihiro; Ouchi Noriyuki; Kihara Shinji; Kawamoto Toshiharu; Sumitsuji Satoru; Funahashi Tohru; Matsuzawa Yuji
Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome.
Diabetes 2002;51(7):2325-8.
-
2002: Maeda Norikazu; Shimomura Iichiro; Kishida Ken; Nishizawa Hitoshi; Matsuda Morihiro; Nagaretani Hiroyuki; Furuyama Naoki; Kondo Hidehiko; Takahashi Masahiko; Arita Yukio; Komuro Ryutaro; Ouchi Noriyuki; Kihara Shinji; Tochino Yoshihiro; Okutomi Keiichi; Horie Masato; Takeda Satoshi; Aoyama Toshifumi; Funahashi Tohru; Matsuzawa Yuji
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30.
Nature medicine 2002;8(7):731-7.
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2002: Arita Yukio; Kihara Shinji; Ouchi Noriyuki; Maeda Kazuhisa; Kuriyama Hiroshi; Okamoto Yoshihisa; Kumada Masahiro; Hotta Kikuko; Nishida Makoto; Takahashi Masahiko; Nakamura Tadashi; Shimomura Iichiro; Muraguchi Masahiro; Ohmoto Yasukazu; Funahashi Tohru; Matsuzawa Yuji
Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell.
Circulation 2002;105(24):2893-8.
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2002: Haque Wasim A; Shimomura Iichiro; Matsuzawa Yuji; Garg Abhimanyu
Serum adiponectin and leptin levels in patients with lipodystrophies.
The Journal of clinical endocrinology and metabolism 2002;87(5):2395.
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2002: Kondo Hidehiko; Shimomura Iichiro; Kishida Ken; Kuriyama Hiroshi; Makino Yasunaka; Nishizawa Hitoshi; Matsuda Morihiro; Maeda Norikazu; Nagaretani Hiroyuki; Kihara Shinji; Kurachi Yoshihisa; Nakamura Tadashi; Funahashi Tohru; Matsuzawa Yuji
Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation.
European journal of biochemistry / FEBS 2002;269(7):1814-26.
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2002: Matsumoto Satoru; Kishida Ken; Shimomura Iichiro; Maeda Norikazu; Nagaretani Hiroyuki; Matsuda Morihiro; Nishizawa Hitoshi; Kihara Shinji; Funahashi Tohru; Matsuzawa Yuji; Yamada A; Yamashita S; Tamura S; Kawata S
Increased plasma HB-EGF associated with obesity and coronary artery disease.
Biochemical and biophysical research communications 2002;292(3):781-6.
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2002: Nishizawa Hitoshi; Yamagata Kazuya; Shimomura Iichiro; Takahashi Masahiko; Kuriyama Hiroshi; Kishida Ken; Hotta Kikuko; Nagaretani Hiroyuki; Maeda Norikazu; Matsuda Morihiro; Kihara Shinji; Nakamura Tadashi; Nishigori Hidekazu; Tomura Hideaki; Moore David D; Takeda Jun; Funahashi Tohru; Matsuzawa Yuji
Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation.
The Journal of biological chemistry 2002;277(2):1586-92.
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2001: Kishida K; Shimomura I; Nishizawa H; Maeda N; Kuriyama H; Kondo H; Matsuda M; Nagaretani H; Ouchi N; Hotta K; Kihara S; Kadowaki T; Funahashi T; Matsuzawa Y
Enhancement of the aquaporin adipose gene expression by a peroxisome proliferator-activated receptor gamma.
The Journal of biological chemistry 2001;276(51):48572-9.
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2001: Maeda N; Takahashi M; Funahashi T; Kihara S; Nishizawa H; Kishida K; Nagaretani H; Matsuda M; Komuro R; Ouchi N; Kuriyama H; Hotta K; Nakamura T; Shimomura I; Matsuzawa Y
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.
Diabetes 2001;50(9):2094-9.
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2001: Kishida K; Shimomura I; Kondo H; Kuriyama H; Makino Y; Nishizawa H; Maeda N; Matsuda M; Ouchi N; Kihara S; Kurachi Y; Funahashi T; Matsuzawa Y
Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel.
The Journal of biological chemistry 2001;276(39):36251-60.
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2001: Takahashi M; Nagaretani H; Funahashi T; Nishizawa H; Maeda N; Kishida K; Kuriyama H; Shimomura I; Maeda K; Hotta K; Ouchi N; Kihara S; Nakamura T; Yamashita S; Matsuzawa Y
The expression of SPARC in adipose tissue and its increased plasma concentration in patients with coronary artery disease.
Obesity research 2001;9(7):388-93.
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2001: Matsuda M; Korn B S; Hammer R E; Moon Y A; Komuro R; Horton J D; Goldstein J L; Brown M S; Shimomura I
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.
Genes & development 2001;15(10):1206-16.
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2000: Repa J J; Liang G; Ou J; Bashmakov Y; Lobaccaro J M; Shimomura I; Shan B; Brown M S; Goldstein J L; Mangelsdorf D J
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.
Genes & development 2000;14(22):2819-30.
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2000: Shimomura I; Matsuda M; Hammer R E; Bashmakov Y; Brown M S; Goldstein J L
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice.
Molecular cell 2000;6(1):77-86.
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2000: Takahashi M; Arita Y; Yamagata K; Matsukawa Y; Okutomi K; Horie M; Shimomura I; Hotta K; Kuriyama H; Kihara S; Nakamura T; Yamashita S; Funahashi T; Matsuzawa Y
Genomic structure and mutations in adipose-specific gene, adiponectin.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24(7):861-8.
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2000: Kakuma T; Lee Y; Higa M; Wang Z w; Pan W; Shimomura I; Unger R H
Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8536-41.
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2000: Kishida K; Kuriyama H; Funahashi T; Shimomura I; Kihara S; Ouchi N; Nishida M; Nishizawa H; Matsuda M; Takahashi M; Hotta K; Nakamura T; Yamashita S; Tochino Y; Matsuzawa Y
Aquaporin adipose, a putative glycerol channel in adipocytes.
The Journal of biological chemistry 2000;275(27):20896-902.
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1999: Shimomura I; Bashmakov Y; Ikemoto S; Horton J D; Brown M S; Goldstein J L
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(24):13656-61.
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1999: Shimomura I; Bashmakov Y; Horton J D
Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus.
The Journal of biological chemistry 1999;274(42):30028-32.
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1999: Shimomura I; Hammer R E; Ikemoto S; Brown M S; Goldstein J L
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.
Nature 1999;401(6748):73-6.
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1999: Horton J D; Shimomura I
Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis.
Current opinion in lipidology 1999;10(2):143-50.
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1999: Arita Y; Kihara S; Ouchi N; Takahashi M; Maeda K; Miyagawa J; Hotta K; Shimomura I; Nakamura T; Miyaoka K; Kuriyama H; Nishida M; Yamashita S; Okubo K; Matsubara K; Muraguchi M; Ohmoto Y; Funahashi T; Matsuzawa Y
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
Biochemical and biophysical research communications 1999;257(1):79-83.
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1999: Funahashi T; Nakamura T; Shimomura I; Maeda K; Kuriyama H; Takahashi M; Arita Y; Kihara S; Matsuzawa Y
Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity.
Internal medicine (Tokyo, Japan) 1999;38(2):202-6.
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1998: Shimomura I; Shimano H; Korn B S; Bashmakov Y; Horton J D
Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver.
The Journal of biological chemistry 1998;273(52):35299-306.
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1998: Korn B S; Shimomura I; Bashmakov Y; Hammer R E; Horton J D; Goldstein J L; Brown M S
Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).
The Journal of clinical investigation 1998;102(12):2050-60.
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1998: Shimomura I; Hammer R E; Richardson J A; Ikemoto S; Bashmakov Y; Goldstein J L; Brown M S
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy.
Genes & development 1998;12(20):3182-94.
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1998: Horton J D; Shimomura I; Brown M S; Hammer R E; Goldstein J L; Shimano H
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.
The Journal of clinical investigation 1998;101(11):2331-9.
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1998: Horton J D; Bashmakov Y; Shimomura I; Shimano H
Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):5987-92.
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1998: Kuriyama H; Yamashita S; Shimomura I; Funahashi T; Ishigami M; Aragane K; Miyaoka K; Nakamura T; Takemura K; Man Z; Toide K; Nakayama N; Fukuda Y; Lin M C; Wetterau J R; Matsuzawa Y
Enhanced expression of hepatic acyl-coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation.
Hepatology (Baltimore, Md.) 1998;27(2):557-62.
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1997: Shimomura I; Bashmakov Y; Shimano H; Horton J D; Goldstein J L; Brown M S
Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12354-9.
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1997: Shimano H; Shimomura I; Hammer R E; Herz J; Goldstein J L; Brown M S; Horton J D
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.
The Journal of clinical investigation 1997;100(8):2115-24.
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1997: Shimano H; Horton J D; Shimomura I; Hammer R E; Brown M S; Goldstein J L
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
The Journal of clinical investigation 1997;99(5):846-54.
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1997: Shimomura I; Shimano H; Horton J D; Goldstein J L; Brown M S
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.
The Journal of clinical investigation 1997;99(5):838-45.
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1996: Takahashi M; Funahashi T; Shimomura I; Miyaoka K; Matsuzawa Y
Plasma leptin levels and body fat distribution.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(12):751-2.
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1996: Yoshida S; Yamashita S; Tokunaga K; Yamane M; Shinohara E; Keno Y; Nishida M; Kotani K; Shimomura I; Kobayashi H; Nakamura T; Miyagawa J; Kameda-Takemura K; Odaka H; Ikeda H; Matsuzawa Y
Visceral fat accumulation and vascular complications associated with VMH lesioning of spontaneously non-insulin-dependent diabetic GK rat.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1996;20(10):909-16.
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1996: Shimano H; Horton J D; Hammer R E; Shimomura I; Brown M S; Goldstein J L
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
The Journal of clinical investigation 1996;98(7):1575-84.
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1996: Shimomura I; Funahashi T; Takahashi M; Maeda K; Kotani K; Nakamura T; Yamashita S; Miura M; Fukuda Y; Takemura K; Tokunaga K; Matsuzawa Y
Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity.
Nature medicine 1996;2(7):800-3.
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1996: Shimomura I; Takahashi M; Tokunaga K; Keno Y; Nakamura T; Yamashita S; Takemura K; Yamamoto T; Funahashi T; Matsuzawa Y
Rapid enhancement of acyl-CoA synthetase, LPL, and GLUT-4 mRNAs in adipose tissue of VMH rats.
The American journal of physiology 1996;270(6 Pt 1):E995-1002.
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1996: Maeda K; Okubo K; Shimomura I; Funahashi T; Matsuzawa Y; Matsubara K
cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1).
Biochemical and biophysical research communications 1996;221(2):286-9.
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1996: Yamashita S; Nakamura T; Shimomura I; Nishida M; Yoshida S; Kotani K; Kameda-Takemuara K; Tokunaga K; Matsuzawa Y
Insulin resistance and body fat distribution.
Diabetes care 1996;19(3):287-91.
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1995: Matsuzawa Y; Nakamura T; Shimomura I; Kotani K
Visceral fat accumulation and cardiovascular disease.
Obesity research 1995;3 Suppl 5():645S-647S.
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1995: Matsuzawa Y; Shimomura I; Nakamura T; Keno Y; Kotani K; Tokunaga K
Pathophysiology and pathogenesis of visceral fat obesity.
Obesity research 1995;3 Suppl 2():187S-194S.
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1995: Yamane M; Jiao S; Kihara S; Shimomura I; Yanagi K; Tokunaga K; Kawata S; Odaka H; Ikeda H; Yamashita S
Increased proportion of plasma apoB-48 to apoB-100 in non-insulin-dependent diabetic rats: contribution of enhanced apoB mRNA editing in the liver.
Journal of lipid research 1995;36(8):1676-85.
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1995: Funahashi T; Shimomura I; Hiraoka H; Arai T; Takahashi M; Nakamura T; Nozaki S; Yamashita S; Takemura K; Tokunaga K
Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats.
Biochemical and biophysical research communications 1995;211(2):469-75.
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1995: Shimomura I; Matsuzawa Y
[Metabolic steps related to fat accumulation]
Nippon rinsho. Japanese journal of clinical medicine 1995;53 Suppl():127-32.
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1995: Matsuzawa Y; Shimomura I; Nakamura T; Keno Y; Tokunaga K
Pathophysiology and pathogenesis of visceral fat obesity.
Annals of the New York Academy of Sciences 1995;748():399-406.
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1994: Matsuzawa Y; Shimomura I; Nakamura T; Keno Y; Tokunaga K
Pathophysiology and pathogenesis of visceral fat obesity.
Diabetes research and clinical practice 1994;24 Suppl():S111-6.
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1994: Nakamura T; Tokunaga K; Shimomura I; Nishida M; Yoshida S; Kotani K; Islam A H; Keno Y; Kobatake T; Nagai Y
Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men.
Atherosclerosis 1994;107(2):239-46.
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1994: Kotani K; Tokunaga K; Fujioka S; Kobatake T; Keno Y; Yoshida S; Shimomura I; Tarui S; Matsuzawa Y
Sexual dimorphism of age-related changes in whole-body fat distribution in the obese.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1994;18(4):207-2.
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1994: Keno Y; Tokunaga K; Fujioka S; Kobatake T; Kotani K; Yoshida S; Nishida M; Shimomura I; Matsuo T; Odaka H
Marked reduction of pancreatic insulin content in male ventromedial hypothalamic-lesioned spontaneously non-insulin-dependent diabetic (Goto-Kakizaki) rats.
Metabolism: clinical and experimental 1994;43(1):32-7.
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1993: Kurachi H; Adachi H; Ohtsuka S; Morishige K; Amemiya K; Keno Y; Shimomura I; Tokunaga K; Miyake A; Matsuzawa Y
Involvement of epidermal growth factor in inducing obesity in ovariectomized mice.
The American journal of physiology 1993;265(2 Pt 1):E323-31.
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1993: Shimomura I; Tokunaga K; Kotani K; Keno Y; Yanase-Fujiwara M; Kanosue K; Jiao S; Funahashi T; Kobatake T; Yamamoto T
Marked reduction of acyl-CoA synthetase activity and mRNA in intra-abdominal visceral fat by physical exercise.
The American journal of physiology 1993;265(1 Pt 1):E44-50.
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1993: Matsuzawa Y; Shimomura I; Nakamura T; Keno Y; Tokunaga K
Pathophysiology and pathogenesis of visceral fat obesity.
Annals of the New York Academy of Sciences 1993;676():270-8.
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1992: Nozaki S; Shimomura I; Funahashi T; Menju M; Kubo M; Matsuzawa Y
Stimulation of the activity and mRNA level of hepatic triacylglycerol lipase by triiodothyronine in HepG2 cells.
Biochimica et biophysica acta 1992;1127(3):298-302.
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1992: Shimomura I; Tokunaga K; Jiao S; Funahashi T; Keno Y; Kobatake T; Kotani K; Suzuki H; Yamamoto T; Tarui S
Marked enhancement of acyl-CoA synthetase activity and mRNA, paralleled to lipoprotein lipase mRNA, in adipose tissues of Zucker obese rats (fa/fa).
Biochimica et biophysica acta 1992;1124(2):112-8.
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