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Tooru Shimosegawa

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Shin Hamada; Morihisa Hirota; Atsushi Kanno; Kazuhiro Kikuta; Kiyoshi Kume; Atsushi Masamune; Shin Miura; Fuyuhiko Motoi; Kennichi Satoh; Jun Unno; Michiaki Unno; Shinichi Egawa; Tooru Shimosegawa
miR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin.
Tomoyuki Koike; Kenichiro Nakagawa; Hiroyuki Endo; Katsunori Iijima; Tooru Shimosegawa
Barrett's esophageal cancer in which magnifying narrow-band imaging was useful for diagnosing extension under the squamous epithelium.
Atsushi Masamune; Kiyoshi Kume; Tooru Shimosegawa
Sex and age differences in alcoholic pancreatitis in Japan: a multicenter nationwide survey.

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2013: Shin Hamada; Morihisa Hirota; Atsushi Kanno; Kazuhiro Kikuta; Kiyoshi Kume; Atsushi Masamune; Shin Miura; Fuyuhiko Motoi; Kennichi Satoh; Jun Unno; Michiaki Unno; Shinichi Egawa; Tooru Shimosegawa
miR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin.
Journal of cellular physiology 2013;228(6):1255-63.
2013: Tomoyuki Koike; Kenichiro Nakagawa; Hiroyuki Endo; Katsunori Iijima; Tooru Shimosegawa
Barrett's esophageal cancer in which magnifying narrow-band imaging was useful for diagnosing extension under the squamous epithelium.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2013;25 Suppl 2():181-3.
2013: Atsushi Masamune; Kiyoshi Kume; Tooru Shimosegawa
Sex and age differences in alcoholic pancreatitis in Japan: a multicenter nationwide survey.
Pancreas 2013;42(4):578-83.
2013: Atsushi Masamune; Shin Miura; Eriko Nakano; Shin Hamada; Kazuhiro Kikuta; Tetsuya Takikawa; Tooru Shimosegawa
The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice.
Scandinavian journal of gastroenterology 2013;48(5):602-9.
2013: Kazuhiro Kikuta; Atsushi Masamune; Eriko Nakano; Shin Hamada; Tetsuya Takikawa; Tooru Shimosegawa
Pancreatic stellate cells reduce insulin expression and induce apoptosis in pancreatic β-cells.
Biochemical and biophysical research communications 2013;433(3):292-7.
2013: Rintaro Moroi; Hisashi Shiga; Yosuke Shimodaira; Katsuya Endo; Takahiko Horiuchi; Yoichi Kakuta; Yoshitake Kanazawa; Yoshitaka Kinouchi; Masatake Kuroha; Seiichi Takahashi; Tooru Shimosegawa
FCGR3A-158 polymorphism influences the biological response to infliximab in Crohn's disease through affecting the ADCC activity.
Immunogenetics 2013;65(4):265-71.
2013: Atsushi Masamune; Eriko Nakano; Hiroyuki Ariga; Yoichi Kakuta; Kiyoshi Kume; Tooru Shimosegawa
Identification of novel missense CTRC variants in Japanese patients with chronic pancreatitis.
Gut 2013;62(4):653-4.
2013: Takeshi Kanno; Tomoyuki Koike; Hidetomo Konishi; Motoki Ohyauchi; Nozomu Sano; Norihiro Shimada; Yasuhiko Abe; Sho Asonuma; Tomoaki Atsumi; Tatsuya Hoshi; Kastunori Iijima; Hirotaka Ito; Tooru Shimosegawa
Peptic ulcers after the Great East Japan earthquake and tsunami: possible existence of psychosocial stress ulcers in humans.
Journal of gastroenterology 2013;48(4):483-90.
2013: Atsushi Masamune; Tooru Shimosegawa
Pancreatic stellate cells--multi-functional cells in the pancreas.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2013;13(2):102-5.
2013: Tomoyuki Koike; Kenichiro Nakagawa; Katsunori Iijima; Tooru Shimosegawa
Endoscopic resection (endoscopic submucosal dissection/endoscopic mucosal resection) for superficial Barrett's esophageal cancer.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2013;25 Suppl 1():20-8.
2013: Junji Ueda; Takao Ohtsuka; Tooru Shimosegawa; Masao Tanaka; Shoji Tokunaga
Surgery for chronic pancreatitis decreases the risk for pancreatic cancer: a multicenter retrospective analysis.
Surgery 2013;153(3):357-64.
2013: Atsushi Masamune; Noriaki Suzuki; Tetsuya Takikawa; Michiaki Unno; Hiroyuki Ariga; Shinichi Egawa; Shin Hamada; Shintaro Hayashi; Morihisa Hirota; Atsushi Kanno; Kazuhiro Kikuta; Kiyoshi Kume; Tooru Shimosegawa
Connexins regulate cell functions in pancreatic stellate cells.
Pancreas 2013;42(2):308-16.
2013: H Shiga; Takayuki Kajiura; Yoshitaka Kinouchi; J Shinozaki; M Suzuki; Sho Takagi; Seiichi Takahashi; Tooru Shimosegawa
Author reply: Comment to "Changes of faecal microbiota in patients with Crohn's disease treated with an elemental diet and total parenteral nutrition".
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2013;45(2):177-8.
2013: Wataru Iwai; Tomoyuki Koike; Kaname Uno; Yasuhiko Abe; Naoki Asano; Katsunori Iijima; Akira Imatani; Tooru Shimosegawa
Gastric hypochlorhydria is associated with an exacerbation of dyspeptic symptoms in female patients.
Journal of gastroenterology 2013;48(2):214-21.
2013: Katsuya Endo; Yoichi Kakuta; Yoshitaka Kinouchi; Hisashi Shiga; Seiichi Takahashi; Tooru Shimosegawa
Short and long-term outcomes of endoscopic balloon dilatation for Crohn's disease strictures.
World journal of gastroenterology : WJG 2013;19(1):86-91.
2013: K Endo; Y Kakuta; Yoshitaka Kinouchi; R Moroi; H Shiga; Seiichi Takahashi; Tooru Shimosegawa
Unique findings on endoscopy with narrow-band imaging in colonic lesions of Henoch-Schönlein purpura.
Endoscopy 2013;45 Suppl 2 UCTN():E65-6.
2013: Yasuteru Kondo; Masashi Ninomiya; Eiji Kakazu; Osamu Kimura; Tooru Shimosegawa
Hepatitis B surface antigen could contribute to the immunopathogenesis of hepatitis B virus infection.
ISRN gastroenterology 2013;2013():935295.
2013: Hisashi Shiga; Hiroki Aizawa; Katsuya Endo; Yoichi Kakuta; Tatsuya Kikuchi; Tomoya Kimura; Yoshitaka Kinouchi; Masatake Kuroha; Masaki Matsuura; Teruko Miyazawa; Eiki Nomura; Nobuya Obana; Shinya Oomori; Yuichirou Sato; Manabu Shiraki; Sho Takagi; Hiroki Takahashi; Shuichiro Takahashi; Seiichi Takahashi; Gen Tominaga; Ken Umemura; Hiroshi Yokoyama; Tooru Shimosegawa
Life-event stress induced by the Great East Japan Earthquake was associated with relapse in ulcerative colitis but not Crohn's disease: a retrospective cohort study.
BMJ open 2013;3(2):.
2013: Takeshi Kanno; Tomoyuki Koike; Hidetomo Konishi; Motoki Ohyauchi; Nozomu Sano; Norihiro Shimada; Yasuhiko Abe; Sho Asonuma; Tomoaki Atsumi; Tatsuya Hoshi; Katsunori Iijima; Hirotaka Ito; Tooru Shimosegawa
Hemorrhagic ulcers after Great East Japan Earthquake and Tsunami: features of post-disaster hemorrhagic ulcers.
Digestion 2013;87(1):40-6.
2013: N Ara; N Asano; K Iijima; T Koike; K Uno; Tooru Shimosegawa
Serious laryngeal edema during endoscopic resection for squamous cell carcinoma of the esophagus.
Endoscopy 2013;45(4):313-5.
2013: Ken Umemura; Sho Takagi; Shuichiro Takahashi; Seiichi Takahashi; Yoshitaka Kinouchi; Takayuki Masuda; Daisuke Shibuya; Hisashi Shiga; Takenobu Shimada; Tooru Shimosegawa
Prognostic and diagnostic significance of tumor budding associated with β-catenin expression in submucosal invasive colorectal carcinoma.
The Tohoku journal of experimental medicine 2013;229(1):53-9.
2013: Tomohiro Masaka; Nobuyuki Ara; Naoki Asano; Kiyotaka Asanuma; Hiroyuki Endo; Katsunori Iijima; Akira Imatani; Fumitake Ishiyama; Tomoyuki Koike; Tooru Shimosegawa
Gender differences in oesophageal mucosal injury in a reflux oesophagitis model of rats.
Gut 2013;62(1):6-14.
2012: Shin Miura; Jun Unno; Shin Hamada; Morihisa Hirota; Atsushi Kanno; Kazuhiro Kikuta; Kiyoshi Kume; Atsushi Masamune; Tooru Shimosegawa
[Case report; Multiple gastrointestinal stromal tumors associated with neurofibromatosis type I preoperatively diagnosed by endoscopic ultrasound-guided fine-needle aspiration: report of a case and review of literature].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2012;101(12):3510-2.
2012: E Patchen Dellinger; Christopher E Forsmark; Peter Layer; Philippe Lévy; Enrique Maraví-Poma; Maxim S Petrov; Tooru Shimosegawa; Ajith K Siriwardena; Generoso Uomo; David C Whitcomb; John A Windsor
Determinant-based classification of acute pancreatitis severity: an international multidisciplinary consultation.
Annals of surgery 2012;256(6):875-80.
2012: Yasuteru Kondo; Masahito Miura; Masashi Ninomiya; Takehiko Igarashi; Jun Inoue; Eiji Kakazu; Osamu Kimura; Koju Kobayashi; Tomoo Kobayashi; Keiichi Tamai; Yasuhito Tanaka; Yoshiyuki Ueno; Takeshi Yamamoto; Tooru Shimosegawa
Sequential immunological analysis of HBV/HCV co-infected patients during Peg-IFN/RBV therapy.
Journal of gastroenterology 2012;47(12):1323-35.
2012: Katsunori Iijima; Toshimitsu Iwabuchi; Tomoyuki Koike; Yasuhiko Abe; Nobuyuki Ara; Naoki Asano; Hiroyuki Endo; Hirohiko Shinkai; Kaname Uno; Tooru Shimosegawa
Biphasic effects of H. pylori infection on low-dose aspirin-induced gastropathy depending on the gastric acid secretion level.
Journal of gastroenterology 2012;47(12):1290-7.
2012: Tooru Shimosegawa
The amendment of the Clinical Diagnostic Criteria in Japan (JPS2011) in response to the proposal of the International Consensus of Diagnostic Criteria (ICDC) for autoimmune pancreatitis.
Pancreas 2012;41(8):1341-2.
2012: Tomoyuki Oikawa; Yasuhiko Abe; Naoki Asano; Jun Fushiya; Katsunori Iijima; Akira Imatani; Tomoyuki Koike; Yutaka Kondo; Motoki Ohyauchi; Tooru Shimosegawa
Gene polymorphisms of NOD1 and interleukin-8 influence the susceptibility to erosive esophagitis in Helicobacter pylori infected Japanese population.
Human immunology 2012;73(11):1184-9.
2012: Kiyoshi Kume; Atsushi Masamune; Shin Miura; Hiroyuki Ariga; Shin Hamada; Shintaro Hayashi; Morihisa Hirota; Atsushi Kanno; Kazuhiro Kikuta; Noriaki Suzuki; Tetsuya Takikawa; Tooru Shimosegawa
Do genetic variants in the SPINK1 gene affect the level of serum PSTI?
Journal of gastroenterology 2012;47(11):1267-74.
2012: Yasuteru Kondo; Yoshiyuki Ueno; Tooru Shimosegawa
Double filtration plasmapheresis could induce a favorable immune response for chronic hepatitis C therapy.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 2012;16(5):478-9.
2012: Kaname Uno; Yatsuhiko Abe; Nobuyuki Ara; Naoki Asano; Katsunori Iijima; Tomoyuki Koike; Tooru Shimosegawa
A pilot study of scheduled endoscopic balloon dilation with oral agent tranilast to improve the efficacy of stricture dilation after endoscopic submucosal dissection of the esophagus.
Journal of clinical gastroenterology 2012;46(9):e76-82.
2012: Gen Kusaka; Kaname Uno; Naoki Asano; Hiroyuki Endo; Katsunori Iijima; Akira Imatani; Tomoyuki Koike; Tooru Shimosegawa
The role of nitric oxide in the induction of caudal-type homeobox 2 through epidermal growth factor receptor in the development of Barrett's esophagus.
Scandinavian journal of gastroenterology 2012;47(10):1148-58.
2012: Jun Inoue; Eiji Kakazu; Naoki Kawagishi; Kaori Kawamura; Osamu Kimura; Yoshitaka Kinouchi; Tomoo Kobayashi; Yasuteru Kondo; Yutaka Mano; Masahito Miura; Hirofumi Niitsuma; Masashi Ninomiya; Noriyuki Obara; Yoshiyuki Ueno; Takeshi Yamamoto; Tooru Shimosegawa
Association between S21 substitution in the core protein of hepatitis B virus and fulminant hepatitis.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2012;55(2):147-52.
2012: Morihisa Hirota; Hiromichi Ito; Atsushi Kanno; Kazuhiro Kikuta; Kiyoshi Kume; Atsushi Masamune; Akihiko Satoh; Kennichi Satoh; Hiroyuki Ariga; Shin Hamada; Jun Unno; Tooru Shimosegawa
Early detection of low enhanced pancreatic parenchyma by contrast-enhanced computed tomography predicts poor prognosis of patients with acute pancreatitis.
Pancreas 2012;41(7):1099-104.
2012: Atsushi Masamune; Tooru Shimosegawa
[Alcohol and pancreatitis].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2012;109(9):1526-34.
2012: Atsushi Kanno; Kazuhiro Kikuta; Kiyoshi Kume; Atsushi Masamune; Kenji Notohara; Kennichi Satoh; Fumiyoshi Fujishima; Shin Hamada; Morihisa Hirota; Kazuyuki Ishida; Jun Unno; Tooru Shimosegawa
Diagnosis of autoimmune pancreatitis by EUS-FNA by using a 22-gauge needle based on the International Consensus Diagnostic Criteria.
Gastrointestinal endoscopy 2012;76(3):594-602.
2012: Waku Hatta; Katsunori Iijima; Akira Imatani; Tomoyuki Koike; Naoki Asano; Kaname Uno; Tooru Shimosegawa
A prospective comparative study of optical coherence tomography and EUS for tumor staging of superficial esophageal squamous cell carcinoma.
Gastrointestinal endoscopy 2012;76(3):548-55.
2012: Hisashi Shiga; Katsuya Endo; Takayuki Kajiura; Yoichi Kakuta; Yoshitaka Kinouchi; Kenichi Negoro; Junko Shinozaki; Manabu Suzuki; Sho Takagi; Seiichi Takahashi; Tooru Shimosegawa
Changes of faecal microbiota in patients with Crohn's disease treated with an elemental diet and total parenteral nutrition.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2012;44(9):736-42.
2012: Kaname Uno; Satoshi Yokosawa; Yasuhiko Abe; Naoki Asano; Katsunori Iijima; Akira Imatani; Tomoyuki Koike; Tooru Shimosegawa
Endoscopic submucosal dissection combined with endoscopic injection sclerotherapy for early gastric cancer on gastric fundal varices.
Surgical laparoscopy, endoscopy & percutaneous techniques 2012;22(4):e226-9.
2012: Atsushi Kanno; Kazuhiro Kikuta; Shinichi Kuriyama; Atsushi Masamune; Isao Nishimori; Tooru Shimosegawa; Ichiro Tsuji; Morihisa Hirota
Nationwide epidemiological survey of autoimmune pancreatitis in Japan.
Pancreas 2012;41(6):835-9.
2012: Shin Hamada; Morihisa Hirota; Kazuhiro Kikuta; Masayoshi Kobune; Atsushi Masamune; Kennichi Satoh; Noriaki Suzuki; Tetsuya Takikawa; Hirofumi Hamada; Tooru Shimosegawa
Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells.
Biochemical and biophysical research communications 2012;421(2):349-54.
2012: Raynoo Thanan; Yasuhiko Abe; Yusuke Hiraku; Katsunori Iijima; Tomoyuki Koike; Ning Ma; Mariko Murata; Shinji Oikawa; Somchai Pinlaor; Tooru Shimosegawa; Shosuke Kawanishi
Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression.
Biochemical and biophysical research communications 2012;421(2):280-5.
2012: Atsushi Kanno; Kazuhiro Kikuta; Atsushi Masamune; Morihisa Hirota; Tooru Shimosegawa
Successful treatment of benign biliary stricture by a covered self-expandable metallic stent in a patient with chronic pancreatitis.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2012;24 Suppl 1():43-8.
2012: Yoshiaki Kawaguchi; Masami Ogawa; Fumio Omata; Tooru Shimosegawa; Hiroyuki Ito; Tetsuya Mine
Randomized controlled trial of pancreatic stenting to prevent pancreatitis after endoscopic retrograde cholangiopancreatography.
World journal of gastroenterology : WJG 2012;18(14):1635-41.
2012: Morihisa Hirota; Yasuyuki Kihara; Kazuhiro Kikuta; Kenji Kimura; Kiyoshi Kume; Shinichi Kuriyama; Atsushi Masamune; Akihiko Satoh; Tooru Shimosegawa; Ichiro Tsuji; Shin Hamada
The sixth nationwide epidemiological survey of chronic pancreatitis in Japan.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2012;12(2):79-84.
2012: Masashi Ninomiya; Yuichiro Nishida; Yoshiyuki Ueno; Ryo Funayama; Jun Inoue; Eiji Kakazu; Osamu Kimura; Yasuteru Kondo; Takeshi Nagashima; Keiko Nakayama; Tooru Shimosegawa
Use of illumina deep sequencing technology to differentiate hepatitis C virus variants.
Journal of clinical microbiology 2012;50(3):857-66.
2012: Yoshitaka Kinouchi; Hisashi Shiga; Katsuya Endo; Seiichi Takahashi; Tooru Shimosegawa
[Genetics of inflammatory bowel disease].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 1():66-72.
2012: Katsunori Iijima; Kazuhiko Ishihara; Toshimitsu Iwabuchi; Wataru Iwai; Yayoi Kamata; Tomoyuki Koike; Yasuhiko Abe; Nobuyuki Ara; Takafumi Ichikawa; Tooru Shimosegawa
Association of gastric acid and mucus secretion level with low-dose aspirin-induced gastropathy.
Journal of gastroenterology 2012;47(2):150-8.
2012: Shin Hamada; Morihisa Hirota; Hiromichi Ito; Atsushi Kanno; Kazuhiro Kikuta; Kiyoshi Kume; Atsushi Masamune; Kennichi Satoh; Jun Umino; Tooru Shimosegawa
The homeobox gene MSX2 determines chemosensitivity of pancreatic cancer cells via the regulation of transporter gene ABCG2.
Journal of cellular physiology 2012;227(2):729-38.
2012: Tooru Shimosegawa; Minoru Tada; Naotaka Fujita; Keiji Hanada; Sachiko Tanaka
[Discussion meeting on is it possible to detect pancreatic cancer in early stage?].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2012;101(1):120-40.
2012: Kennichi Satoh; Tooru Shimosegawa
[Pancreatic tumor: progress in diagnosis and treatment. Topics: I. Pancreatic carcinoma: 2. Pathogenesis and pathobiology in pancreatic cancer.--The molecular mechanisms of carcinogenesis, and invasion and metastasis in pancreatic cancer].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2012;101(1):7-16.
2012: Tooru Shimosegawa
[Pancreatic tumor: progress in diagnosis and treatment. Editorial: trend of clinical management of pancreatic tumors].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2012;101(1):1-3.
2012: Eiji Kakazu; Yasuteru Kondo; Tooru Shimosegawa
The Relationship between Renal Dysfunction and Abnormalities of the Immune System in Patients with Decompensated Cirrhosis.
ISRN gastroenterology 2012;2012():123826.
2012: Osamu Kimura; Yasuteru Kondo; Tooru Shimosegawa
PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma.
PPAR research 2012;2012():574180.
2012: Kennichi Satoh; Shin Hamada; Tooru Shimosegawa
MSX2 in pancreatic tumor development and its clinical application for the diagnosis of pancreatic ductal adenocarcinoma.
Frontiers in physiology 2012;3():430.
2012: Katsuya Endo; Yoichi Kakuta; Yoshitaka Kinouchi; Masatake Kuroha; Hisashi Shiga; Seiichi Takahashi; Tooru Shimosegawa
Two cases of diffuse duodenitis associated with ulcerative colitis.
Case reports in gastrointestinal medicine 2012;2012():396521.
2012: Naoki Asano; Takashi Chiba; Jun Fushiya; Katsunori Iijima; Akira Imatani; Xiaoyi Jin; Tomoyuki Koike; Nobuyuki Ara; Shiho Terai; Tooru Shimosegawa
Eradication therapy is effective for Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma.
The Tohoku journal of experimental medicine 2012;228(3):223-7.
2012: Terumi Kamisawa; Atsushi Kanno; Sawako Kuruma; Atsushi Masamune; Kazuro Chiba; Seiichi Hara; Taku Tabata; Tooru Shimosegawa
Recent advances in autoimmune pancreatitis.
Frontiers in physiology 2012;3():374.
2012: Morihisa Hirota; Atsushi Kanno; Kazuhiro Kikuta; Kiyoshi Kume; Tooru Shimosegawa; Jun Unno; Shin Hamada; Atsushi Masamune
Distinct clinical features of two patients that progressed from the early phase of chronic pancreatitis to the advanced phase.
The Tohoku journal of experimental medicine 2012;228(3):173-80.
2012: Shin Hamada; Atsushi Masamune; Kennichi Satoh; Tooru Shimosegawa
Regulators of epithelial mesenchymal transition in pancreatic cancer.
Frontiers in physiology 2012;3():254.
2012: Kazushige Uchida; Tooru Shimosegawa; Atsushi Masamune; Kazuichi Okazaki
Prevalence of IgG4-Related Disease in Japan Based on Nationwide Survey in 2009.
International journal of rheumatology 2012;2012():358371.
2012: Takashi Chiba; Katsunori Iijima; Tomoyuki Koike; Naoki Asano; Kaname Uno; Tooru Shimosegawa
A case of severe esophageal intramural pseudodiverticulosis whose symptoms were ameliorated by oral administration of anti-fungal medicine.
Case reports in gastroenterology 2012;6(1):103-10.
2012: Yasuteru Kondo; Yoshiyuki Ueno; Tooru Shimosegawa
Biological significance of HCV in various kinds of lymphoid cells.
International journal of microbiology 2012;2012():647581.
2012: Shin Hamada; Morihisa Hirota; Atsushi Kanno; Kazuhiro Kikuta; Kiyoshi Kume; Atsushi Masamune; Kennichi Satoh; Wataru Fujibuchi; Jun Unno; Tooru Shimosegawa
MiR-126 acts as a tumor suppressor in pancreatic cancer cells via the regulation of ADAM9.
Molecular cancer research : MCR 2012;10(1):3-10.
2012: Masashi Ninomiya; Yoshiyuki Ueno; Tooru Shimosegawa
PBC: Animal Models of Cholangiopathies and Possible Endogenous Viral Infections.
International journal of hepatology 2012;2012():649290.
2011: Seiichi Takahashi; Katsuya Endo; Yoshitaka Kinouchi; Hisashi Shiga; Tooru Shimosegawa
[The management of ulcerative colitis in remission stage and the strategies for colorectal cancer surveillance in ulcerative colitis].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2011;108(12):1983-95.
2011: Yasuteru Kondo; Masashi Ninomiya; Noriyuki Obara; Jun Inoue; Eiji Kakazu; Koju Kobayashi; Yoshiyuki Ueno; Yuta Wakui; Tooru Shimosegawa
Rapid reduction of hepatitis C virus-Core protein in the peripheral blood improve the immunological response in chronic hepatitis C patients.
Hepatology research : the official journal of the Japan Society of Hepatology 2011;41(12):1153-68.
2011: Katsuya Endo; Yoichi Kakuta; Yoshitake Kanazawa; Yoshitaka Kinouchi; Masatake Kuroha; Rintaro Moroi; Hitoshi Nagasawa; Hisashi Shiga; Yosuke Shimodaira; Takashi Arai; Seiichi Takahashi; Tooru Shimosegawa
[Clinical courses and pregnancy outcomes in Japanese women with inflammatory bowel disease].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2011;108(11):1858-71.
2011: Kaname Uno; Yasuhiko Abe; Naoki Asano; Waku Hatta; Katsunori Iijima; Tomoyuki Koike; Gen Kusaka; Tooru Shimosegawa
Direct measurement of gastroesophageal reflux episodes in patients with squamous cell carcinoma by 24-h pH-impedance monitoring.
The American journal of gastroenterology 2011;106(11):1923-9.
2011: Morihisa Hirota; Hiromichi Ito; Atsushi Kanno; Kazuhiro Kikuta; Kiyoshi Kume; Atsushi Masamune; Kennichi Satoh; Hiroyuki Ariga; Tsutomu Chiba; Shin Hamada; Masashi Tsuda; Yoshihisa Tsuji; Jun Unno; Tooru Shimosegawa
Perfusion computed tomography findings of autoimmune pancreatitis.
Pancreas 2011;40(8):1295-301.
2011: Jun Inoue; Eiji Kakazu; Yasuteru Kondo; Hirofumi Niitsuma; Masashi Ninomiya; Yoshiyuki Ueno; Yuta Wakui; Koji Fukushima; Tooru Shimosegawa
Enhanced replication of hepatitis B virus with frameshift in the precore region found in fulminant hepatitis patients.
The Journal of infectious diseases 2011;204(7):1017-25.
2011: Kaname Uno; Naoki Asano; Katsunori Iijima; Katsuaki Kato; Gen Kusaka; Tooru Shimosegawa
The balance between 4-hydroxynonenal and intrinsic glutathione/glutathione S-transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas.
Molecular carcinogenesis 2011;50(10):781-90.
2011: Evangelos Kalaitzakis; Terumi Kamisawa; Atsushi Kanno; Michael Levy; Kazuichi Okazaki; Stephen P Pereira; Neomal S Sandanayake; Kashif Sheikh; Tooru Shimosegawa; Naoki Takahashi; Mark D Topazian; Kazushige Uchida; Zahir Amin; Todd H Baron; Michael H Chapman; Suresh Chari; Nicholas I Church; Naoto Egawa; Gavin J Johnson; George J M Webster
Endoscopic retrograde cholangiography does not reliably distinguish IgG4-associated cholangitis from primary sclerosing cholangitis or cholangiocarcinoma.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2011;9(9):800-803.e2.
2011: Morihisa Hirota; Hiromichi Ito; Atsushi Kanno; Kazuhiro Kikuta; Kiyoshi Kume; Atsushi Masamune; Fuyuhiko Motoi; Kennichi Satoh; Hiroyuki Ariga; Tohru Asakura; Shinichi Egawa; Shin Hamada; Jun Unno; Michiaki Unno; Tooru Shimosegawa
Long-period pancreatic stenting for painful chronic calcified pancreatitis required higher medical costs and frequent hospitalizations compared with surgery.
Pancreas 2011;40(6):946-50.
2011: Terumi Kamisawa; Myung-Hwan Kim; Guenter Kloeppel; Kyu Taek Lee; Markus M Lerch; Wei-Chih Liao; Matthias Lohr; Julia Mayerle; Kazuichi Okazaki; Tilman Pickartz; D Nageshwar Reddy; Alexander Schneider; Tooru Shimosegawa; Hsiu-Po Wang; George J M Webster; Jens Werner; Frank Bergmann; Suresh T Chari; Jae Bock Chung; Luca Frulloni; Samuel A Giday; Vay Liang W Go
Clinical profile of autoimmune pancreatitis and its histological subtypes: an international multicenter survey.
Pancreas 2011;40(6):809-14.
2011: Takashi Arai; Katsuya Endo; Yoichi Kakuta; Yoshitake Kanazawa; Tomoya Kimura; Yoshitaka Kinouchi; Masatake Kuroha; Rintaro Moroi; Hitoshi Nagasawa; Kenichi Negoro; Hisashi Shiga; Yosuke Shimodaira; Hiroyuki Aihara; Seiichi Takahashi; Tooru Shimosegawa
Increased expression of NKX2.3 mRNA transcribed from the risk haplotype for ulcerative colitis in the involved colonic mucosa.
Human immunology 2011;72(7):587-91.
2011: Tetsuhide Ito; Taichi Nakamura; Nao Fujimori; Yusuke Niina; Hisato Igarashi; Takamasa Oono; Masahiko Uchida; Ken Kawabe; Ryoichi Takayanagi; Isao Nishimori; Makoto Otsuki; Tooru Shimosegawa
Characteristics of pancreatic diabetes in patients with autoimmune pancreatitis.
Journal of digestive diseases 2011;12(3):210-6.
2011: Toru Horii; Tomoyuki Koike; Yasuhiko Abe; Ryosuke Kikuchi; Hiroyuki Unakami; Katsunori Iijima; Akira Imatani; Shuichi Ohara; Tooru Shimosegawa
Two distinct types of cancer of different origin may be mixed in gastroesophageal junction adenocarcinomas in Japan: evidence from direct evaluation of gastric acid secretion.
Scandinavian journal of gastroenterology 2011;46(6):710-9.
2011: Atsushi Masamune; Hiroyuki Ariga; Kiyoshi Kume; Yoichi Kakuta; Kennichi Satoh; Akihiko Satoh; Tooru Shimosegawa
Genetic background is different between sentinel and recurrent acute pancreatitis.
Journal of gastroenterology and hepatology 2011;26(6):974-8.
2011: Naoki Asano; Hiroyuki Endo; Waku Hatta; Katsunori Iijima; Akira Imatani; Toshimitsu Iwabuchi; Wataru Iwai; Tomoyuki Koike; Shiho Terai; Kaname Uno; Yasuhiko Abe; Tooru Shimosegawa
Signet Ring Cell Gastric Cancer Occurring after Radiation Therapy for Helicobacter pylori-Uninfected Mucosa-Associated Lymphoid Tissue Lymphoma.
Case reports in gastroenterology 2011;5(2):325-9.
2011: Kennichi Satoh; Tooru Shimosegawa; Atsushi Masamune; Morihisa Hirota; Kazuhiro Kikuta; Yasuyuki Kihara; Shinichi Kuriyama; Ichiro Tsuji; Akihiko Satoh; Shin Hamada
Nationwide epidemiological survey of acute pancreatitis in Japan.
Pancreas 2011;40(4):503-7.
2011: Katsunori Iijima; Nobuyuki Ara; Yasuhiko Abe; Tomoyuki Koike; Wataru Iwai; Kaname Uno; Naoki Asano; Akira Imatani; Shuichi Ohara; Tooru Shimosegawa
Gastric acid secretion level modulates the association between Helicobacter pylori infection and low-dose aspirin-induced gastropathy.
Journal of gastroenterology 2011;46(5):612-9.
2011: Tooru Shimosegawa; Suresh T Chari; Luca Frulloni; Terumi Kamisawa; Shigeyuki Kawa; Mari Mino-Kenudson; Myung-Hwan Kim; Günter Klöppel; Markus M Lerch; Matthias Löhr; Kenji Notohara; Kazuichi Okazaki; Alexander Schneider; Lizhi Zhang
International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology.
Pancreas 2011;40(3):352-8.
2011: Hiromichi Ito; Kennichi Satoh; Shin Hamada; Morihisa Hirota; Atsushi Kanno; Kazuyuki Ishida; Jun Unno; Atsushi Masamune; Yu Katayose; Michiaki Unno; Tooru Shimosegawa
The evaluation of MSX2 mRNA expression level in biliary brush cytological specimens.
Anticancer research 2011;31(3):1011-7.
2011: Terumi Kamisawa; Myung-Hwan Kim; Wei-Chih Liao; Quanda Liu; Vallath Balakrishnan; Kazuichi Okazaki; Tooru Shimosegawa; Jae Bock Chung; Kyu Taek Lee; Hsiu-Po Wang; Tsung-Chun Lee; Gourdas Choudhuri
Clinical characteristics of 327 Asian patients with autoimmune pancreatitis based on Asian diagnostic criteria.
Pancreas 2011;40(2):200-5.
2011: Katsuya Endo; Hisashi Shiga; Yoichi Kakuta; Seiichi Takahashi; Yoshitaka Kinouchi; Tooru Shimosegawa
[Maintenance therapy with biologic agents for Crohn's disease: impact of scheduled maintenance therapy with infliximab].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2011;108(3):401-9.
2011: Yoshitaka Kinouchi; Yoichi Kakuta; Seiichi Takahashi; Tooru Shimosegawa
[Long-term prognosis of Crohn's disease].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2011;108(3):381-7.
2011: Jun Inoue; Yoshiyuki Ueno; Y Wakui; Hirofumi Niitsuma; Kouhei Fukushima; Yoko Yamagiwa; Masaaki Shiina; Yasuteru Kondo; Eiji Kakazu; K Tamai; N Obara; Takao Iwasaki; Tooru Shimosegawa
Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients: influence of hepatitis B virus genotype and resistance mutation pattern.
Journal of viral hepatitis 2011;18(3):206-15.
2011: Yasuteru Kondo; Yoshiyuki Ueno; Eiji Kakazu; Koju Kobayashi; Masaaki Shiina; Keiichi Tamai; Keigo Machida; Jun Inoue; Yuta Wakui; Koji Fukushima; Noriyuki Obara; Osamu Kimura; Tooru Shimosegawa
Lymphotropic HCV strain can infect human primary naïve CD4+ cells and affect their proliferation and IFN-γ secretion activity.
Journal of gastroenterology 2011;46(2):232-41.
2011: M Kuroha; Y Sato; H Shiga; K Endo; Y Kakuta; Yoshitaka Kinouchi; Seiichi Takahashi; Tooru Shimosegawa
Magnifying endoscopy findings in follicular lymphoma of the rectum using narrow band imaging.
Endoscopy 2011;43 Suppl 2 UCTN():E346-7.
2011: Eiji Kakazu; Osamu Kimura; Yasuteru Kondo; Masashi Ninomiya; Koji Fukushima; Jun Inoue; Keiichi Tamai; Yoshiyuki Ueno; Yuta Wakui; Tooru Shimosegawa
Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis.
PloS one 2011;6(8):e23402.
2011: Yasuhiko Abe; Katsunori Iijima; Akira Imatani; Kazuhiko Ishida; Tomoyuki Koike; Go Miyata; Toyohiko Yuki; Tooru Shimosegawa
Esophageal Adenocarcinoma Developing after Eradication of Helicobacter pylori.
Case reports in gastroenterology 2011;5(2):355-60.
2011: Koji Fukushima; Jun Inoue; Eiji Kakazu; Naoki Kawagishi; Yasuteru Kondo; Masashi Ninomiya; Naoko Saito; Susumu Satomi; Yoshiyuki Ueno; Yuta Wakui; Tooru Shimosegawa
The nutritional index 'CONUT' is useful for predicting long-term prognosis of patients with end-stage liver diseases.
The Tohoku journal of experimental medicine 2011;224(3):215-9.
2011: Atsushi Kanno; Kenji Kimura; Atsushi Masamune; Fuyuhiko Motoi; Kennichi Satoh; Shinichi Egawa; Shin Hamada; Morihisa Hirota; Kazuyuki Ishida; Taro Shuin; Michiaki Unno; Tooru Shimosegawa
Serous cystic neoplasms of the whole pancreas in a patient with von Hippel-Lindau disease.
Internal medicine (Tokyo, Japan) 2011;50(12):1293-8.
2011: Shin Hamada; Tooru Shimosegawa
Biomarkers of pancreatic cancer.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2011;11 Suppl 2():14-9.
2011: Masatoshi Kudo; Kenji Yamao; Tooru Shimosegawa
The prognosis of patients with pancreatic cancer is extremely poor. Preface.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2011;11 Suppl 2():1-2.
2011: Jun Inoue; Yoshiyuki Ueno; Tooru Shimosegawa
Management of chronic hepatitis B patients: efficacy & limitation of nucleos(t)ide analogues.
The Indian journal of medical research 2011;133():11-3.
2011: Ryousuke Kikuchi; Yasuhiko Abe; Katsunori Iijima; Tomoyuki Koike; Nobuyuki Ara; Kaname Uno; Kiyotaka Asanuma; Naoki Asano; Akira Imatani; Tooru Shimosegawa
Low serum levels of pepsinogen and gastrin 17 are predictive of extensive gastric atrophy with high-risk of early gastric cancer.
The Tohoku journal of experimental medicine 2011;223(1):35-44.
2011: Masashi Kawamura; Shu Abe; K Oikawa; Shiho Terai; Masahiro Saito; Daisuke Shibuya; Katsuaki Kato; Yoshifumi Inomata; Shuichi Ohara; Tooru Shimosegawa
Magnifying endoscopic findings of the surface structure of non-cancerous mucosa surrounding differentiated and undifferentiated gastric carcinoma.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2011;23(1):37-42.
2011: Shin Hamada; Kennichi Satoh; Morihisa Hirota; Atsushi Kanno; Kazuyuki Ishida; Jun Umino; Hiromichi Ito; Kazuhiro Kikuta; Kiyoshi Kume; Atsushi Masamune; Yu Katayose; Michiaki Unno; Tooru Shimosegawa
Calcium-binding protein S100P is a novel diagnostic marker of cholangiocarcinoma.
Cancer science 2011;102(1):150-6.
2011: Kennichi Satoh; Shin Hamada; Atsushi Kanno; Kazuyuki Ishida; Hiromichi Ito; Morihisa Hirota; Atsushi Masamune; Shinichi Egawa; Michiaki Unno; Tooru Shimosegawa
Evaluation of MSX2 mRNA in brush cytology specimens distinguished pancreatic carcinoma from chronic pancreatitis.
Cancer science 2011;102(1):157-61.
2011: Yasuhiko Abe; Katsunori Iijima; Shuichi Ohara; Tomoyuki Koike; Nobuyuki Ara; Kaname Uno; Naoki Asano; Akira Imatani; Katsuaki Kato; Daisuke Shibuya; Tooru Shimosegawa
A Japanese case series of 12 patients with esophageal eosinophilia.
Journal of gastroenterology 2011;46(1):25-30.
2010: Kazuhiro Kikuta; Atsushi Masamune; Takashi Watanabe; Hiroyuki Ariga; Hiromichi Itoh; Shin Hamada; Kennichi Satoh; Shinichi Egawa; Michiaki Unno; Tooru Shimosegawa
Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells.
Biochemical and biophysical research communications 2010;403(3-4):380-4.
2010: Yoshitake Kanazawa; Yasuyuki Saito; Yana Supriatna; Hiroyuki Tezuka; Takenori Kotani; Yoji Murata; Hideki Okazawa; Hiroshi Ohnishi; Yoshitaka Kinouchi; Yoshihisa Nojima; Toshiaki Ohteki; Tooru Shimosegawa; Takashi Matozaki
Role of SIRPα in regulation of mucosal immunity in the intestine.
Genes to cells : devoted to molecular & cellular mechanisms 2010;15(12):1189-200.
2010: Shigeyuki Kobayashi; Yasuhiko Abe; Manabu Tashiro; Tomoyuki Koike; Katsunori Iijima; Akira Imatani; Shuichi Ohara; Satoshi Watanabe; Shin Fukudo; Tooru Shimosegawa
Brain activity following esophageal acid infusion using positron emission tomography.
World journal of gastroenterology : WJG 2010;16(43):5481-9.
2010: Tomoyuki Oikawa; Katsunori Iijima; Tomoyuki Koike; Kaname Uno; Toru Horii; Wataru Iwai; Yasuhiko Abe; Naoki Asano; Akira Imatani; Tooru Shimosegawa
Deficient aldehyde dehydrogenase 2 is associated with increased risk for esophageal squamous cell carcinoma in the presence of gastric hypochlorhydria.
Scandinavian journal of gastroenterology 2010;45(11):1338-44.
2010: Hiroyuki Endo; Katsunori Iijima; Kiyotaka Asanuma; Nobuyuki Ara; Hirotaka Ito; Naoki Asano; Kaname Uno; Tomoyuki Koike; Akira Imatani; Tooru Shimosegawa
Exogenous luminal nitric oxide exposure accelerates columnar transformation of rat esophagus.
International journal of cancer. Journal international du cancer 2010;127(9):2009-19.
2010: Morihisa Hirota; Tooru Asakura; Atsushi Kanno; Tooru Shimosegawa
Endoscopic treatment for chronic pancreatitis: indications, technique, results.
Journal of hepato-biliary-pancreatic sciences 2010;17(6):770-5.
2010: Osamu Kimura; Takeshi Takahashi; Naoto Ishii; Yuki Inoue; Yoshiyuki Ueno; Takayuki Kogure; Koji Fukushima; Masaaki Shiina; Yoko Yamagiwa; Yasuteru Kondo; Jun Inoue; Eiji Kakazu; Takao Iwasaki; Naoki Kawagishi; Tooru Shimosegawa; Kazuo Sugamura
Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines.
Cancer science 2010;101(10):2145-55.
2010: Atsushi Masamune; Takashi Watanabe; Kazuhiro Kikuta; Kennichi Satoh; Atsushi Kanno; Tooru Shimosegawa
Nuclear expression of interleukin-33 in pancreatic stellate cells.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(4):G821-32.
2010: Atsushi Kanno; Kennichi Satoh; Morihisa Hirota; Shin Hamada; Jun Umino; Hiromichi Itoh; Atsushi Masamune; Tohru Asakura; Tooru Shimosegawa
Prediction of invasive carcinoma in branch type intraductal papillary mucinous neoplasms of the pancreas.
Journal of gastroenterology 2010;45(9):952-9.
2010: Keiichi Tamai; Nobuyuki Tanaka; Takashi Nakano; Eiji Kakazu; Yasuteru Kondo; Jun Inoue; Masaaki Shiina; Koji Fukushima; Tomoaki Hoshino; Kouichi Sano; Yoshiyuki Ueno; Tooru Shimosegawa; Kazuo Sugamura
Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein.
Biochemical and biophysical research communications 2010;399(3):384-90.
2010: Noriyuki Obara; Koji Fukushima; Yoshiyuki Ueno; Yuta Wakui; Osamu Kimura; Keiichi Tamai; Eiji Kakazu; Jun Inoue; Yasuteru Kondo; Norihiko Ogawa; Kenta Sato; Tsuyoshi Tsuduki; Kazuyuki Ishida; Tooru Shimosegawa
Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice.
Journal of hepatology 2010;53(2):326-34.
2010: Tetsuhide Ito; Makoto Otsuki; Hisato Igarashi; Yasuyuki Kihara; Ken Kawabe; Taichi Nakamura; Nao Fujimori; Takamasa Oono; Ryoichi Takayanagi; Tooru Shimosegawa
Epidemiological study of pancreatic diabetes in Japan in 2005: a nationwide study.
Pancreas 2010;39(6):829-35.
2010: Yasuteru Kondo; Yoshiyuki Ueno; Koju Kobayashi; Eiji Kakazu; Masaaki Shiina; Jun Inoue; Keiichi Tamai; Yuta Wakui; Yasuhito Tanaka; Masashi Ninomiya; Noriyuki Obara; Koji Fukushima; Motoyasu Ishii; Tomoo Kobayashi; Hirofumi Niitsuma; Satonori Kon; Tooru Shimosegawa
Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes.
The Journal of infectious diseases 2010;202(2):202-13.
2010: Kennichi Satoh; Tooru Shimosegawa
[Gastric inhibitory polypeptide (GIP)].
Nihon rinsho. Japanese journal of clinical medicine 2010;68 Suppl 7():567-70.
2010: Kennichi Satoh; Tooru Shimosegawa
[Neurotensin].
Nihon rinsho. Japanese journal of clinical medicine 2010;68 Suppl 7():269-72.
2010: Terumi Kamisawa; Kenji Notohara; Tooru Shimosegawa
Two clinicopathologic subtypes of autoimmune pancreatitis: LPSP and IDCP.
Gastroenterology 2010;139(1):22-5.
2010: Suresh T Chari; Guenter Kloeppel; Lizhi Zhang; Kenji Notohara; Markus M Lerch; Tooru Shimosegawa
Histopathologic and clinical subtypes of autoimmune pancreatitis: the Honolulu consensus document.
Pancreas 2010;39(5):549-54.
2010: Yuji Ota; Atsushi Masamune; Kazuo Inui; Kiyoshi Kume; Tooru Shimosegawa; Masataka Kikuyama
Phenotypic variability of the homozygous IVS3+2T>C mutation in the serine protease inhibitor Kazal type 1 (SPINK1) gene in patients with chronic pancreatitis.
The Tohoku journal of experimental medicine 2010;221(3):197-201.
2010: Kennichi Satoh; Shin Hamada; Atsushi Kanno; Morihisa Hirota; Jun Umino; Hiromichi Ito; Atsushi Masamune; Shinichi Egawa; Michiaki Unno; Tooru Shimosegawa
Expression of MSX2 predicts malignancy of branch duct intraductal papillary mucinous neoplasm of the pancreas.
Journal of gastroenterology 2010;45(7):763-70.
2010: Shin Takasawa; Michio Kuroki; Koji Nata; Naoya Noguchi; Takayuki Ikeda; Akiyo Yamauchi; Hiroyo Ota; Asako Itaya-Hironaka; Sumiyo Sakuramoto-Tsuchida; Iwao Takahashi; Takeo Yoshikawa; Tooru Shimosegawa; Hiroshi Okamoto
A novel ryanodine receptor expressed in pancreatic islets by alternative splicing from type 2 ryanodine receptor gene.
Biochemical and biophysical research communications 2010;397(2):140-5.
2010: Yoshitaka Kinouchi; Seiichi Takahashi; Tooru Shimosegawa
[Molecular pathogenesis of Crohn's disease].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2010;107(6):855-62.
2010: Tooru Shimosegawa; Keisho Kataoka; Terumi Kamisawa; Hiroyuki Miyakawa; Hirotaka Ohara; Tetsuhide Ito; Satoru Naruse; Naohiro Sata; Koichi Suda; Morihisa Hirota; Yoshifumi Takeyama; Keiko Shiratori; Takashi Hatori; Makoto Otsuki; Yutaka Atomi; Kentaro Sugano; Masao Tanaka
The revised Japanese clinical diagnostic criteria for chronic pancreatitis.
Journal of gastroenterology 2010;45(6):584-91.
2010: Yuta Wakui; Jun Inoue; Yoshiyuki Ueno; Koji Fukushima; Yasuteru Kondo; Eiji Kakazu; Noriyuki Obara; Osamu Kimura; Tooru Shimosegawa
Inhibitory effect on hepatitis B virus in vitro by a peroxisome proliferator-activated receptor-gamma ligand, rosiglitazone.
Biochemical and biophysical research communications 2010;396(2):508-14.
2010: Waku Hatta; Kaname Uno; Tomoyuki Koike; Satoshi Yokosawa; Katsunori Iijima; Akira Imatani; Tooru Shimosegawa
Optical coherence tomography for the staging of tumor infiltration in superficial esophageal squamous cell carcinoma.
Gastrointestinal endoscopy 2010;71(6):899-906.
2010: Terumi Kamisawa; Kazuichi Okazaki; Shigeyuki Kawa; Tooru Shimosegawa; Masao Tanaka
Japanese consensus guidelines for management of autoimmune pancreatitis: III. Treatment and prognosis of AIP.
Journal of gastroenterology 2010;45(5):471-7.
2010: Katsunori Iijima; Tomoyuki Koike; Y Abe; H Yamagishi; N Ara; K Asanuma; K Uno; Akira Imatani; N Nakaya; Shuichi Ohara; Tooru Shimosegawa
Gastric hyposecretion in esophageal squamous-cell carcinomas.
Digestive diseases and sciences 2010;55(5):1349-55.
2010: Seiichi Takahashi; Sho Takagi; Hisashi Shiga; Ken Umemura; Katuya Endo; Yoichi Kakuta; Seiichi Takahashi; Yoshitaka Kinouchi; Tooru Shimosegawa
Scheduled maintenance therapy with infliximab improves the prognosis of Crohn's disease: a single center prospective cohort study in Japan.
The Tohoku journal of experimental medicine 2010;220(3):207-15.
2010: H Ito; Katsunori Iijima; N Ara; K Asanuma; H Endo; N Asano; Tomoyuki Koike; Yasuhiko Abe; Akira Imatani; Tooru Shimosegawa
Reactive nitrogen oxide species induce dilatation of the intercellular space of rat esophagus.
Scandinavian journal of gastroenterology 2010;45(3):282-91.
2010: Atsushi Kanno; Kennichi Satoh; Morihisa Hirota; Shin Hamada; Jun Umino; Hiromichi Itoh; Atsushi Masamune; Shinichi Egawa; Fuyuhiko Motoi; Michiaki Unno; Kazuyuki Ishida; Tooru Shimosegawa
Granular cell tumor of the pancreas: A case report and review of literature.
World journal of gastrointestinal oncology 2010;2(2):121-4.
2010: Atsushi Masamune; Kiyoshi Kume; Kazuhiro Kikuta; Takashi Watanabe; Morihisa Hirota; Kennichi Satoh; Atsushi Kanno; Noriaki Suzuki; Yoichi Kakuta; Tooru Shimosegawa
-651C/T promoter polymorphism in the CD14 gene is associated with severity of acute pancreatitis in Japan.
Journal of gastroenterology 2010;45(2):225-33.
2010: Katsuya Endo; Yoshitaka Kinouchi; Yoichi Kakuta; Nobuo Ueki; Seiichi Takahashi; Tooru Shimosegawa
Involvement of NF-kappa B pathway in TL1A gene expression induced by lipopolysaccharide.
Cytokine 2010;49(2):215-20.
2010: Tooru Shimosegawa; Satoru Naruse; Katsuya Maruyama; Kiyoshi Kume; Atsushi Irisawa
[Alcohol and pancreatic disorders: discussion].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2010;99(1):102-19.
2010: Atsushi Masamune; Tooru Shimosegawa
[Chronic pancreatitis. 2. Its etiology and physiopathology].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2010;99(1):41-7.
2010: Tooru Shimosegawa
[Current status of the care of pancreatitis and future problems].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2010;99(1):1-3.
2010: Suresh T Chari; Guenter Kloeppel; Lizhi Zhang; Kenji Notohara; Markus M Lerch; Tooru Shimosegawa
Histopathologic and clinical subtypes of autoimmune pancreatitis: the honolulu consensus document.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2010;10(6):664-72.
2010: Koji Fukushima; Yoshiyuki Ueno; Tooru Shimosegawa
Treatment of Primary Biliary Cirrhosis: A new challenge?
Hepatology research : the official journal of the Japan Society of Hepatology 2010;40(1):61-8.
2010: Hisashi Shiga; Sho Takagi; Ryusuke Inoue; Yoshitaka Kinouchi; Takayoshi Ohkubo; Seiichi Takahashi; Kenichi Negoro; Hiroshi Yokoyama; Seiichi Kato; Kouhei Fukushima; Nobuo Hiwatashi; Tooru Shimosegawa
What determines the later clinical course of patients who do not undergo colectomy at the first attack? A Japanese cohort study on ulcerative colitis.
Digestion 2010;81(2):104-12.
2010: Tadahiro Takada; Koichi Hirata; Toshihiko Mayumi; Masahiro Yoshida; Miho Sekimoto; Masahiko Hirota; Yasutoshi Kimura; Kazunori Takeda; Shuji Isaji; Keita Wada; Hodaka Amano; Toshifumi Gabata; Shinjyu Arata; Morihisa Hirota; Masamichi Yokoe; Seiki Kiriyama; Takeo Nakayama; Kuni Otomo; Masao Tanaka; Tooru Shimosegawa
Cutting-edge information for the management of acute pancreatitis.
Journal of hepato-biliary-pancreatic sciences 2010;17(1):3-12.
2010: Kazunori Takeda; Masamichi Yokoe; Tadahiro Takada; Keisho Kataoka; Masahiro Yoshida; Toshifumi Gabata; Masahiko Hirota; Toshihiko Mayumi; Masumi Kadoya; Eigoro Yamanouchi; Takayuki Hattori; Miho Sekimoto; Hodaka Amano; Keita Wada; Yasutoshi Kimura; Seiki Kiriyama; Shinju Arata; Yoshifumi Takeyama; Morihisa Hirota; Koichi Hirata; Tooru Shimosegawa
Assessment of severity of acute pancreatitis according to new prognostic factors and CT grading.
Journal of hepato-biliary-pancreatic sciences 2010;17(1):37-44.
2010: Toshihiko Mayumi; Tadahiro Takada; Koichi Hirata; Masahiro Yoshida; Miho Sekimoto; Masahiko Hirota; Yasutoshi Kimura; Kazunori Takeda; Hodaka Amano; Keita Wada; Toshifumi Gabata; Shinjyu Arata; Morihisa Hirota; Masamichi Yokoe; Seiki Kiriyama; Satoru Shikata; Kunihiro Shirai; Takeo Nakayama; Kuni Ohtomo; Masao Tanaka; Tooru Shimosegawa
Pancreatitis bundles.
Journal of hepato-biliary-pancreatic sciences 2010;17(1):87-9.
2010: Atsushi Masamune; Akihiko Satoh; Takashi Watanabe; Kazuhiro Kikuta; Masahiro Satoh; Noriaki Suzuki; Kennichi Satoh; Tooru Shimosegawa
Effects of ethanol and its metabolites on human pancreatic stellate cells.
Digestive diseases and sciences 2010;55(1):204-11.
2009: Jun Inoue; Yoshiyuki Ueno; Futoshi Nagasaki; Yuta Wakui; Yasuteru Kondo; Koji Fukushima; Hirofumi Niitsuma; Tooru Shimosegawa
Enhanced intracellular retention of a hepatitis B virus strain associated with fulminant hepatitis.
Virology 2009;395(2):202-9.
2009: Kouichi Asano; Tomonaga Matsushita; Junji Umeno; Naoya Hosono; Atsushi Takahashi; Takahisa Kawaguchi; Takayuki Matsumoto; Toshiyuki Matsui; Yoichi Kakuta; Yoshitaka Kinouchi; Tooru Shimosegawa; Masayo Hosokawa; Yoshiaki Arimura; Yasuhisa Shinomura; Yutaka Kiyohara; Tatsuhiko Tsunoda; Naoyuki Kamatani; Mitsuo Iida; Yusuke Nakamura; Michiaki Kubo
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
Nature genetics 2009;41(12):1325-9.
2009: Eiji Kakazu; Yoshiyuki Ueno; Yasuteru Kondo; Koji Fukushima; Masaaki Shiina; Jun Inoue; Keiichi Tamai; Masashi Ninomiya; Tooru Shimosegawa
Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis.
Hepatology (Baltimore, Md.) 2009;50(6):1936-45.
2009: Osamu Kido; Koji Fukushima; Yoshiyuki Ueno; Jun Inoue; Douglas M Jefferson; Tooru Shimosegawa
Compensatory role of inducible annexin A2 for impaired biliary epithelial anion-exchange activity of inflammatory cholangiopathy.
Laboratory investigation; a journal of technical methods and pathology 2009;89(12):1374-86.
2009: Takashi Watanabe; Atsushi Masamune; Kazuhiro Kikuta; Morihisa Hirota; Kiyoshi Kume; Kennichi Satoh; Tooru Shimosegawa
Bone marrow contributes to the population of pancreatic stellate cells in mice.
American journal of physiology. Gastrointestinal and liver physiology 2009;297(6):G1138-46.
2009: Atsushi Masamune; Takashi Watanabe; Kazuhiro Kikuta; Tooru Shimosegawa
Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2009;7(11 Suppl):S48-54.
2009: Tooru Shimosegawa; Kiyoshi Kume; Kennichi Satoh
Chronic pancreatitis and pancreatic cancer: prediction and mechanism.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2009;7(11 Suppl):S23-8.
2009: Tooru Shimosegawa; Fred S Gorelick
Inflammation and carcinogenesis in the pancreas and biliary tract: mechanisms and practice.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2009;7(11 Suppl):S1-2.
2009: Vay Liang W Go; David Myers; Tooru Shimosegawa
Congratulations on the 40th anniversaries of the American Pancreatic Association and Japan Pancreas Society.
Pancreas 2009;38(8):843.
2009: Jun Unno; Kennichi Satoh; Morihisa Hirota; Atsushi Kanno; Shin Hamada; Hiromichi Ito; Atsushi Masamune; Nobukazu Tsukamoto; Fuyuhiko Motoi; Shinichi Egawa; Michiaki Unno; Akira Horii; Tooru Shimosegawa
LIV-1 enhances the aggressive phenotype through the induction of epithelial to mesenchymal transition in human pancreatic carcinoma cells.
International journal of oncology 2009;35(4):813-21.
2009: Satoshi Yokosawa; Tomoyuki Koike; Yasushi Kitagawa; Waku Hatta; Kaname Uno; Yasuhiko Abe; Katsunori Iijima; Akira Imatani; Shuichi Ohara; Tooru Shimosegawa
Identification of the layered morphology of the esophageal wall by optical coherence tomography.
World journal of gastroenterology : WJG 2009;15(35):4402-9.
2009: Jeong Yeon Seo; Atsushi Masamune; Tooru Shimosegawa; Hyeyoung Kim
Protective effect of lycopene on oxidative stress-induced cell death of pancreatic acinar cells.
Annals of the New York Academy of Sciences 2009;1171():570-5.
2009: Atsushi Masamune; Kiyoshi Kume; Tooru Shimosegawa
[Pancreatitis-associated genes and development of pancreatic cancer].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2009;106(8):1147-55.
2009: Jun Inoue; Masaharu Takahashi; Hitoshi Mizuo; Kazuyuki Suzuki; Tatsuya Aikawa; Tooru Shimosegawa; Hiroaki Okamoto
Nucleotide substitutions of hepatitis E virus genomes associated with fulminant hepatitis and disease severity.
The Tohoku journal of experimental medicine 2009;218(4):279-84.
2009: Sho Asonuma; Akira Imatani; Naoki Asano; Tomoyuki Oikawa; Hidetomo Konishi; Katsunori Iijima; Tomoyuki Koike; Shuichi Ohara; Tooru Shimosegawa
Helicobacter pylori induces gastric mucosal intestinal metaplasia through the inhibition of interleukin-4-mediated HMG box protein Sox2 expression.
American journal of physiology. Gastrointestinal and liver physiology 2009;297(2):G312-22.
2009: Hiroshi Yamaguchi; Michio Shimizu; Shinichi Ban; Isamu Koyama; Takashi Hatori; Izumi Fujita; Masakazu Yamamoto; Shunji Kawamura; Makio Kobayashi; Kazuyuki Ishida; Takanori Morikawa; Fuyuhiko Motoi; Michiaki Unno; Atsushi Kanno; Kennichi Satoh; Tooru Shimosegawa; Hideki Orikasa; Tomoo Watanabe; Kazuhiko Nishimura; Yoshiro Ebihara; Naoto Koike; Toru Furukawa
Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms.
The American journal of surgical pathology 2009;33(8):1164-72.
2009: Hatsushi Yamagishi; Tomoyuki Koike; Shuichi Ohara; Yasuhiko Abe; Katsunori Iijima; Akira Imatani; Katsuaki Kato; Daisuke Shibuya; Shigemitsu Aida; Tooru Shimosegawa
Clinical characteristics of gastroesophageal reflux disease in Japan.
Hepato-gastroenterology 2009;56(93):1032-4.
2009: Katsunori Iijima; T Ichikawa; S Okada; M Ogawa; Tomoyuki Koike; Shuichi Ohara; Tooru Shimosegawa
Rebamipide, a cytoprotective drug, increases gastric mucus secretion in human: evaluations with endoscopic gastrin test.
Digestive diseases and sciences 2009;54(7):1500-7.
2009: Katsuya Endo; Hisashi Shiga; Yoshitaka Kinouchi; Tooru Shimosegawa
[Inflammatory bowel disease: IBD].
Rinsho byori. The Japanese journal of clinical pathology 2009;57(6):527-32.
2009: H Aizawa; Yoshitaka Kinouchi; Kenichi Negoro; Eiki Nomura; G Imai; Seiichi Takahashi; Sho Takagi; Y Kakuta; Masaki Tosa; A Mochida; Y Matsumura; K Endo; Tooru Shimosegawa
HLA-B is the best candidate of susceptibility genes in HLA for Japanese ulcerative colitis.
Tissue antigens 2009;73(6):569-74.
2009: Kiyoshi Kume; Atsushi Masamune; Y Takagi; Kazuhiro Kikuta; Toshiaki Watanabe; Kennichi Satoh; Akihiko Satoh; Morihisa Hirota; Shin Hamada; Tooru Shimosegawa
A loss-of-function p.G191R variant in the anionic trypsinogen (PRSS2) gene in Japanese patients with pancreatic disorders.
Gut 2009;58(6):820-4.
2009: Sho Takagi; K Utsunomiya; S Kuriyama; H Yokoyama; Seiichi Takahashi; K Umemura; M Iwabuchi; H Takahashi; S Takahashi; Yoshitaka Kinouchi; Nobuo Hiwatashi; Y Funayama; I Sasaki; I Tsuji; Tooru Shimosegawa
Quality of life of patients and medical cost of "half elemental diet" as maintenance therapy for Crohn's disease: secondary outcomes of a randomised controlled trial.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2009;41(6):390-4.
2009: Hiroshi Kimura; Hiroki Miyashita; Yasuhiro Suzuki; Miho Kobayashi; Kazuhide Watanabe; Hikaru Sonoda; Hideki Ohta; Takashi Fujiwara; Tooru Shimosegawa; Yasufumi Sato
Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis.
Blood 2009;113(19):4810-8.
2009: Shiho Terai; Katsunori Iijima; Kiyotaka Asanuma; Nobuyuki Ara; Kaname Uno; Yasuhiko Abe; Tomoyuki Koike; Akira Imatani; Shuichi Ohara; Tooru Shimosegawa
Lack of modulation of gastric emptying by dietary nitrate in healthy volunteers.
The Tohoku journal of experimental medicine 2009;218(1):73-9.
2009: Takayuki Kogure; Yoshiyuki Ueno; Osamu Kimura; Yasuteru Kondo; Jun Inoue; Koji Fukushima; Takao Iwasaki; Tooru Shimosegawa
A novel third generation bisphosphonate, minodronate (YM529), prevented proliferation and migration of hepatocellular carcinoma cells through inhibition of mevalonate pathway.
Hepatology research : the official journal of the Japan Society of Hepatology 2009;39(5):479-89.
2009: Atsushi Masamune; Kazuhiro Kikuta; Toshiaki Watanabe; Kennichi Satoh; M Hirota; S Hamada; Tooru Shimosegawa
Fibrinogen induces cytokine and collagen production in pancreatic stellate cells.
Gut 2009;58(4):550-9.
2009: Noriaki Suzuki; Atsushi Masamune; Kazuhiro Kikuta; Takashi Watanabe; Kennichi Satoh; Tooru Shimosegawa
Ellagic acid inhibits pancreatic fibrosis in male Wistar Bonn/Kobori rats.
Digestive diseases and sciences 2009;54(4):802-10.
2009: Yoichi Kakuta; Nobuo Ueki; Yoshitaka Kinouchi; Kenichi Negoro; Katsuya Endo; Eiki Nomura; Sho Takagi; Seiichi Takahashi; Tooru Shimosegawa
TNFSF15 transcripts from risk haplotype for Crohn's disease are overexpressed in stimulated T cells.
Human molecular genetics 2009;18(6):1089-98.
2009: Takayuki Kogure; Yoshiyuki Ueno; Satoshi Sekiguchi; Kazuyuki Ishida; Takehiko Igarashi; Yuta Wakui; Takao Iwasaki; Tooru Shimosegawa
Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma.
World journal of gastroenterology : WJG 2009;15(10):1267-72.
2009: Yasuhiko Takagi; Atsushi Masamune; Kiyoshi Kume; Akihiko Satoh; Kazuhiro Kikuta; Takashi Watanabe; Kennichi Satoh; Morihisa Hirota; Tooru Shimosegawa
Microsatellite polymorphism in intron 2 of human Toll-like receptor 2 gene is associated with susceptibility to acute pancreatitis in Japan.
Human immunology 2009;70(3):200-4.
2009: Yasuteru Kondo; Keigo Machida; Helene Minyi Liu; Yoshiyuki Ueno; Koju Kobayashi; Takaji Wakita; Tooru Shimosegawa; Michael M C Lai
Hepatitis C virus infection of T cells inhibits proliferation and enhances fas-mediated apoptosis by down-regulating the expression of CD44 splicing variant 6.
The Journal of infectious diseases 2009;199(5):726-36.
2009: Katsunori Iijima; Yasuhiko Abe; Ryosuke Kikuchi; Tomoyuki Koike; Shuichi Ohara; Pentti Sipponen; Tooru Shimosegawa
Serum biomarker tests are useful in delineating between patients with gastric atrophy and normal, healthy stomach.
World journal of gastroenterology : WJG 2009;15(7):853-9.
2009: Takehide Ogihara; Hideki Katagiri; Tetsuya Yamada; Hirohito Kudo; Junta Imai; Yasushi Ishigaki; Yoshinori Hinokio; Yoko Yamagiwa; Yoshiyuki Ueno; Tooru Shimosegawa; Yoshitomo Oka
Peginterferon (PEG-IFN) plus ribavirin combination therapy, but neither interferon nor PGE-IFN alone, induced type 1 diabetes in a patient with chronic hepatitis C.
Internal medicine (Tokyo, Japan) 2009;48(16):1387-90.
2009: Katsunori Iijima; Tomoyuki Koike; Yasuhiko Abe; Nobuyuki Ara; Kaname Uno; Akira Imatani; Shuichi Ohara; Tooru Shimosegawa
Alteration of correlation between serum pepsinogen concentrations and gastric acid secretion after H. pylori eradication.
Journal of gastroenterology 2009;44(8):819-25.
2009: Tooru Shimosegawa; Atsushi Kanno
Autoimmune pancreatitis in Japan: overview and perspective.
Journal of gastroenterology 2009;44(6):503-17.
2009: Jun Inoue; Yoshiyuki Ueno; Futoshi Nagasaki; Takehiro Akahane; Koji Fukushima; Takayuki Kogure; Yasuteru Kondo; Eiji Kakazu; Keiichi Tamai; Osamu Kido; Yu Nakagome; Masashi Ninomiya; Noriyuki Obara; Yuta Wakui; Masaharu Takahashi; Hiroaki Okamoto; Tooru Shimosegawa
Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan.
Journal of gastroenterology 2009;44(4):329-37.
2009: Atsushi Masamune; Tooru Shimosegawa
Signal transduction in pancreatic stellate cells.
Journal of gastroenterology 2009;44(4):249-60.
2009: Yasuhiko Abe; Katsunori Iijima; Tomoyuki Koike; Kiyotaka Asanuma; Akira Imatani; Shuichi Ohara; Tooru Shimosegawa
Barrett's esophagus is characterized by the absence of Helicobacter pylori infection and high levels of serum pepsinogen I concentration in Japan.
Journal of gastroenterology and hepatology 2009;24(1):129-34.
2009: Fumitake Ishiyama; Katsunori Iijima; Kiyotaka Asanuma; Nobuyuki Ara; Jun Yoshitake; Yasuhiko Abe; Tomoyuki Koike; Akira Imatani; Shuichi Ohara; Tooru Shimosegawa
Exogenous luminal nitric oxide exacerbates esophagus tissue damage in a reflux esophagitis model of rats.
Scandinavian journal of gastroenterology 2009;44(5):527-37.
2009: Katsunori Iijima; Tomoyuki Koike; Hitoshi Sekine; Yasuhiko Abe; Kiyotaka Asanuma; Nobuyuki Ara; Kaname Uno; Akira Imatani; Shuichi Ohara; Tooru Shimosegawa
Sustained epithelial proliferation in a functionally irreversible fundic mucosa after Helicobacter pylori eradication.
Journal of gastroenterology 2009;44(1):47-55.
2009: Shin Hamada; Kennichi Satoh; Morihisa Hirota; Wataru Fujibuchi; Atsushi Kanno; Jun Umino; Hiromichi Ito; Akihiko Satoh; Kazuhiro Kikuta; Kiyoshi Kume; Atsushi Masamune; Tooru Shimosegawa
Expression of the calcium-binding protein S100P is regulated by bone morphogenetic protein in pancreatic duct epithelial cell lines.
Cancer science 2009;100(1):103-10.
2008: Keiichi Tamai; Masafumi Toyoshima; Nobuyuki Tanaka; Noriko Yamamoto; Yuji Owada; Hiroshi Kiyonari; Kazuko Murata; Yoshiyuki Ueno; Masao Ono; Tooru Shimosegawa; Nobuo Yaegashi; Masahiko Watanabe; Kazuo Sugamura
Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration.
The American journal of pathology 2008;173(6):1806-17.
2008: Ken Umemura; Sho Takagi; Yasushi Ishigaki; Masahiro Iwabuchi; Shigeru Kuroki; Yoshitaka Kinouchi; Tooru Shimosegawa
Gastrointestinal polyposis with esophageal polyposis is useful for early diagnosis of Cowden's disease.
World journal of gastroenterology : WJG 2008;14(37):5755-9.
2008: Atsushi Masamune; Kazuhiro Kikuta; Takashi Watanabe; Kennichi Satoh; Morihisa Hirota; Tooru Shimosegawa
Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer.
American journal of physiology. Gastrointestinal and liver physiology 2008;295(4):G709-17.
2008: Masae Shinozaki; Shin Fukudo; Michio Hongo; Tooru Shimosegawa; Daisuke Sasaki; Kei Matsueda; Shigeru Harasawa; Soichiro Miura; Tetsuya Mine; Hiroshi Kaneko; Tetsuo Arakawa; Ken Haruma; Akira Torii; Takeshi Azuma; Hiroto Miwa; Mikihiko Fukunaga; Masanori Handa; Shigeru Kitamori; Takeshi Miwa
High prevalence of irritable bowel syndrome in medical outpatients in Japan.
Journal of clinical gastroenterology 2008;42(9):1010-6.
2008: Tomoyuki Koike; Shuichi Ohara; Tooru Shimosegawa
[Pathogenesis of Barrett's esophageal cancer evaluated by gastric acid secretion].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2008;105(9):1330-6.
2008: Y Sato; Sho Takagi; H Aizawa; H Yokoyama; S Takahashi; Y Kakuta; Masaki Tosa; A Mochida; Eiki Nomura; Seiichi Takahashi; Yoshitaka Kinouchi; Tooru Shimosegawa
Useful endoscopic findings for early diagnosis of ulcerative colitis associated colorectal cancer.
Endoscopy 2008;40 Suppl 2():E71-2.
2008: Koji Fukushima; Yoshiyuki Ueno; Jun Inoue; Yuta Wakui; Noriyuki Obara; Osamu Kimura; Osamu Kido; Yu Nakagome; Eiji Kakazu; Yasunori Matsuda; Takayuki Kogure; Yasuteru Kondo; Futoshi Nagasaki; Yoko Yamagiwa; Yugo Ashino; Tooru Shimosegawa
A case of HIV co-infected with hepatitis B virus precore/core deletion mutant treated by entecavir.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(8):842-6.
2008: Hatsushi Yamagishi; Tomoyuki Koike; Shuichi Ohara; Shigeyuki Kobayashi; Ken Ariizumi; Yasuhiko Abe; Katsunori Iijima; Akira Imatani; Yoshifumi Inomata; Katsuaki Kato; Daisuke Shibuya; Shigemitsu Aida; Tooru Shimosegawa
Tongue-like Barrett's esophagus is associated with gastroesophageal reflux disease.
World journal of gastroenterology : WJG 2008;14(26):4196-203.
2008: Atsushi Kanno; Kennichi Satoh; Atsushi Masamune; Morihisa Hirota; Kenji Kimura; Jun Umino; Shin Hamada; Akihiko Satoh; Shinichi Egawa; Fuyuhiko Motoi; Michiaki Unno; Tooru Shimosegawa
Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells.
International journal of cancer. Journal international du cancer 2008;122(12):2707-18.
2008: Futoshi Nagasaki; Yoshiyuki Ueno; Hirofumi Niitsuma; Jun Inoue; Takayuki Kogure; Koji Fukushima; Koju Kobayashi; Tooru Shimosegawa
Analysis of the entire nucleotide sequence of hepatitis B causing consecutive cases of fatal fulminant hepatitis in Miyagi Prefecture Japan.
Journal of medical virology 2008;80(6):967-73.
2008: Ken Ariizumi; Tomoyuki Koike; Shuichi Ohara; Yoshifumi Inomata; Yasuhiko Abe; Katsunori Iijima; Akira Imatani; Tomoyoshi Oka; Tooru Shimosegawa
Incidence of reflux esophagitis and H pylori infection in diabetic patients.
World journal of gastroenterology : WJG 2008;14(20):3212-7.
2008: Kennichi Satoh; Atsushi Kanno; Shin Hamada; Morihisa Hirota; Jun Umino; Atsushi Masamune; Shinichi Egawa; Fuyuhiko Motoi; Michiaki Unno; Tooru Shimosegawa
Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas.
Oncology reports 2008;19(5):1185-90.
2008: Y Matsumura; Yoshitaka Kinouchi; Eiki Nomura; Kenichi Negoro; Y Kakuta; K Endo; H Aizawa; Sho Takagi; Seiichi Takahashi; Tooru Shimosegawa
HLA-DRB1 alleles influence clinical phenotypes in Japanese patients with ulcerative colitis.
Tissue antigens 2008;71(5):447-52.
2008: Hatsushi Yamagishi; Tomoyuki Koike; Shuichi Ohara; Toru Horii; Ryousuke Kikuchi; Shigeyuki Kobayashi; Yasuhiko Abe; Katsunori Iijima; Akira Imatani; Kaori Suzuki; Takanori Hishinuma; Junichi Goto; Tooru Shimosegawa
Stronger inhibition of gastric acid secretion by lafutidine, a novel H2 receptor antagonist, than by the proton pump inhibitor lansoprazole.
World journal of gastroenterology : WJG 2008;14(15):2406-10.
2008: Hatsushi Yamagishi; Tomoyuki Koike; Shuichi Ohara; Toru Horii; Ryousuke Kikuchi; Shigeyuki Kobayashi; Yasuhiko Abe; Katsunori Iijima; Akira Imatani; Kaori Suzuki; Takanori Hishinuma; Junichi Goto; Tooru Shimosegawa
Early effects of Lansoprazole orally disintegrating tablets on intragastric pH in CYP2C19 extensive metabolizers.
World journal of gastroenterology : WJG 2008;14(13):2049-54.
2008: Kennichi Satoh; Shin Hamada; Kenji Kimura; Atsushi Kanno; Morihisa Hirota; Jun Umino; Wataru Fujibuchi; Atsushi Masamune; Naoki Tanaka; Koh Miura; Shinichi Egawa; Fuyuhiko Motoi; Michiaki Unno; Barbara K Vonderhaar; Tooru Shimosegawa
Up-regulation of MSX2 enhances the malignant phenotype and is associated with twist 1 expression in human pancreatic cancer cells.
The American journal of pathology 2008;172(4):926-39.
2008: Jun Inoue; Yoshiyuki Ueno; Takayuki Kogure; Futoshi Nagasaki; Osamu Kimura; Noriyuki Obara; Osamu Kido; Yu Nakagome; Eiji Kakazu; Yasunori Matsuda; Koji Fukushima; Haruna Segawa; Ichiro Nakajima; Yasuto Itoyama; Masaharu Takahashi; Hiroaki Okamoto; Tooru Shimosegawa
Analysis of the full-length genome of hepatitis B virus in the serum and cerebrospinal fluid of a patient with acute hepatitis B and transverse myelitis.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2008;41(4):301-4.
2008: Koji Fukushima; Yoshiyuki Ueno; Hirokazu Kanegane; Yoko Yamagiwa; Jun Inoue; Osamu Kido; Futoshi Nagasaki; Takayuki Kogure; Eiji Kakazu; Yu Nakagome; Yasunori Matsuda; Noriyuki Obara; Osamu Kimura; Tooru Shimosegawa
A case of severe recurrent hepatitis with common variable immunodeficiency.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(4):415-20.
2008: Hatsushi Yamagishi; Tomoyuki Koike; Shuichi Ohara; Shigeyuki Kobayashi; Ken Ariizumi; Yasuhiko Abe; Katsunori Iijima; Akira Imatani; Yoshifumi Inomata; Katsuaki Kato; Daisuke Shibuya; Shigemitsu Aida; Tooru Shimosegawa
Prevalence of gastroesophageal reflux symptoms in a large unselected general population in Japan.
World journal of gastroenterology : WJG 2008;14(9):1358-64.
2008: Tooru Shimosegawa; Kiyoshi Kume; Atsushi Masamune
SPINK1, ADH2, and ALDH2 gene variants and alcoholic chronic pancreatitis in Japan.
Journal of gastroenterology and hepatology 2008;23 Suppl 1():S82-6.
2008: N Ara; K Iijima; K Asanuma; J Yoshitake; S Ohara; Tooru Shimosegawa; T Yoshimura
Disruption of gastric barrier function by luminal nitrosative stress: a potential chemical insult to the human gastro-oesophageal junction.
Gut 2008;57(3):306-13.
2008: Masashi Ninomiya; Masaharu Takahashi; Tsutomu Nishizawa; Tooru Shimosegawa; Hiroaki Okamoto
Development of PCR assays with nested primers specific for differential detection of three human anelloviruses and early acquisition of dual or triple infection during infancy.
Journal of clinical microbiology 2008;46(2):507-14.
2008: Chikashi Shibata; Yuji Funayama; Kouhei Fukushima; Tatsuya Ueno; Atsushi Kohyama; Kennichi Satoh; Tooru Shimosegawa; Tetsuya Yamagiwa; Iwao Sasaki
The glucagon provocative test for the diagnosis and treatment of Zollinger-Ellison syndrome.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2008;12(2):344-9.
2008: Noriyuki Obara; Yoshiyuki Ueno; Koji Fukushima; Yu Nakagome; Eiji Kakazu; Osamu Kimura; Yuta Wakui; Osamu Kido; Masashi Ninomiya; Takayuki Kogure; Jun Inoue; Yasuteru Kondo; Masaaki Shiina; Takao Iwasaki; Takeshi Yamamoto; Tooru Shimosegawa
Transient elastography for measurement of liver stiffness measurement can detect early significant hepatic fibrosis in Japanese patients with viral and nonviral liver diseases.
Journal of gastroenterology 2008;43(9):720-8.
2008: Yasunori Matsuda; Yoko Yamagiwa; Koji Fukushima; Yoshiyuki Ueno; Tooru Shimosegawa
Expression of galectin-3 involved in prognosis of patients with hepatocellular carcinoma.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(11):1098-111.
2008: Makoto Otsuki; Jae Bock Chung; Kazuichi Okazaki; Myung-Hwan Kim; Terumi Kamisawa; Shigeyuki Kawa; Seung Woo Park; Tooru Shimosegawa; Kyutaek Lee; Tetsuhide Ito; Isao Nishimori; Kenji Notohara; Satoru Naruse; Shigeru B H Ko; Yasuyuki Kihara
Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis.
Journal of gastroenterology 2008;43(6):403-8.
2008: Atsushi Masamune; Kazuhiro Kikuta; Takashi Watanabe; Kennichi Satoh; Akihiko Satoh; Tooru Shimosegawa
Pancreatic stellate cells express Toll-like receptors.
Journal of gastroenterology 2008;43(5):352-62.
2008: Shiho Terai; Katsunori Iijima; Katsuaki Kato; Naohiro Dairaku; Tatsuhiko Suzuki; Masayoshi Yoshida; Tomoyuki Koike; Yasushi Kitagawa; Akira Imatani; Hitoshi Sekine; Shuichi Ohara; Tooru Shimosegawa
Long-term outcomes of gastric mucosa-associated lymphoid tissue lymphomas after Helicobacter pylori eradication therapy.
The Tohoku journal of experimental medicine 2008;214(1):79-87.
2008: Atsushi Masamune; Takashi Watanabe; Kazuhiro Kikuta; Kennichi Satoh; Tooru Shimosegawa
NADPH oxidase plays a crucial role in the activation of pancreatic stellate cells.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(1):G99-G108.
2007: Emiko Mikami; Noriatsu Kanno; Yoshiyuki Ueno; Tooru Shimosegawa
Retrospective evaluation of tumor-mass-reduction therapy for the prognosis of recurrent hepatocellular carcinoma.
Hepatology international 2007;1(4):460-8.
2007: Shin Hamada; Kennichi Satoh; Morihisa Hirota; Kenji Kimura; Atsushi Kanno; Atsushi Masamune; Tooru Shimosegawa
Bone morphogenetic protein 4 induces epithelial-mesenchymal transition through MSX2 induction on pancreatic cancer cell line.
Journal of cellular physiology 2007;213(3):768-74.
2007: Eiji Kakazu; Noriatsu Kanno; Yoshiyuki Ueno; Tooru Shimosegawa
Extracellular branched-chain amino acids, especially valine, regulate maturation and function of monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):7137-46.
2007: Kaname Uno; Katsuaki Kato; Tomoaki Atsumi; Takehito Suzuki; Jun Yoshitake; Hidetoshi Morita; Shuichi Ohara; Yashige Kotake; Tooru Shimosegawa; Tetsuhiko Yoshimura
Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(5):G1004-12.
2007: Takayuki Kogure; Takao Iwasaki; Yoshiyuki Ueno; Noriatsu Kanno; Koji Fukushima; Yoko Yamagiwa; Futoshi Nagasaki; Eiji Kakazu; Yasunori Matsuda; Osamu Kido; Yu Nakagome; Masashi Ninomiya; Tooru Shimosegawa
Complete remission of a case of hepatocellular carcinoma with tumor invasion in inferior vena cava and with pulmonary metastasis successfully treated with repeated arterial infusion chemotherapy.
Hepato-gastroenterology 2007;54(79):2113-6.
2007: Yoshiyuki Ueno; Koji Fukushima; Yu Nakagome; Osamu Kido; Tooru Shimosegawa
Bioinformatic approach for cholangiocyte pathophysiology.
Hepatology research : the official journal of the Japan Society of Hepatology 2007;37 Suppl 3():S444-8.
2007: Futoshi Nagasaki; Hirofumi Niitsuma; Yoshiyuki Ueno; Jun Inoue; Takayuki Kogure; Koji Fukushima; Tooru Shimosegawa
The high incidence of the emergence of entecavir-resistant mutants among patients infected with lamivudine-resistant hepatitis B virus.
The Tohoku journal of experimental medicine 2007;213(2):181-6.
2007: Katsuyoshi Kudo; Yuji Funayama; Kohei Fukushima; Chikashi Shibata; Kenichi Takahashi; Hitoshi Ogawa; Tatsuya Ueno; Sho Haneda; Kazuhiro Watanabe; Atsushi Koyama; Keiichi Hayashi; Nobuo Hiwatashi; Yoshitaka Kinouchi; Tooru Shimosegawa; Iwao Sasaki
[Carcinoma arising from ileorectal fistula in a patient with Crohn's disease].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2007;104(10):1492-7.
2007: Tomoaki Atsumi; Katsuaki Kato; Kaname Uno; Katsunori Iijima; Tomoyuki Koike; Akira Imatani; Shuichi Ohara; Tooru Shimosegawa
Pathophysiological role of the activation of p38 mitogen-activated protein kinases in poorly differentiated gastric cancer.
Pathology international 2007;57(10):635-44.
2007: Tooru Shimosegawa
[Diagnosis and treatment of autoimmune pancreatitis].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2007;96(9):1946-52.
2007: Keiichi Tamai; Nobuyuki Tanaka; Atsuki Nara; Akitsugu Yamamoto; Ichiro Nakagawa; Tamotsu Yoshimori; Yoshiyuki Ueno; Tooru Shimosegawa; Kazuo Sugamura
Role of Hrs in maturation of autophagosomes in mammalian cells.
Biochemical and biophysical research communications 2007;360(4):721-7.
2007: Hiroshi Yokoyama; Sho Takagi; Shinichi Kuriyama; Shuichiro Takahashi; Hiroki Takahashi; Masahiro Iwabuchi; Seiichi Takahashi; Yoshitaka Kinouchi; Nobuo Hiwatashi; Ichiro Tsuji; Tooru Shimosegawa
Effect of weekend 5-aminosalicylic acid (mesalazine) enema as maintenance therapy for ulcerative colitis: results from a randomized controlled study.
Inflammatory bowel diseases 2007;13(9):1115-20.
2007: Takayuki Kogure; Yoshiyuki Ueno; Koji Fukushima; Futoshi Nagasaki; Jun Inoue; Eiji Kakazu; Yasunori Matsuda; Osamu Kido; Yu Nakagome; Osamu Kimura; Noriyuki Obara; Yuta Wakui; Takao Iwasaki; Tooru Shimosegawa
Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment.
World journal of gastroenterology : WJG 2007;13(32):4394-7.
2007: A Mochida; Yoshitaka Kinouchi; Kenichi Negoro; Seiichi Takahashi; Sho Takagi; Eiki Nomura; Y Kakuta; Masaki Tosa; Tooru Shimosegawa
Butyrophilin-like 2 gene is associated with ulcerative colitis in the Japanese under strong linkage disequilibrium with HLA-DRB1*1502.
Tissue antigens 2007;70(2):128-35.
2007: Katsunori Iijima; Tomoyuk Koike; Yasuhiko Abe; Yoshifumi Inomata; Hitoshi Sekine; Akira Imatani; Naoki Nakaya; Shuichi Ohara; Tooru Shimosegawa
Extensive gastric atrophy: an increased risk factor for superficial esophageal squamous cell carcinoma in Japan.
The American journal of gastroenterology 2007;102(8):1603-9.
2007: Yu Nakagome; Yoshiyuki Ueno; Takayuki Kogure; Koji Fukushima; Yuki Moritoki; William M Ridgway; M Eric Gershwin; Tooru Shimosegawa
Autoimmune cholangitis in NOD.c3c4 mice is associated with cholangiocyte-specific Fas antigen deficiency.
Journal of autoimmunity 2007;29(1):20-9.
2007: Masashi Ninomiya; Tsutomu Nishizawa; Masaharu Takahashi; Felipe R Lorenzo; Tooru Shimosegawa; Hiroaki Okamoto
Identification and genomic characterization of a novel human torque teno virus of 3.2 kb.
The Journal of general virology 2007;88(Pt 7):1939-44.
2007: Yusuke Hattori; Yuichi Komachi; Toru Asakura; Tooru Shimosegawa; Gen-Ichi Kanai; Hideo Tashiro; Hidetoshi Sato
In vivo Raman study of the living rat esophagus and stomach using a micro-Raman probe under an endoscope.
Applied spectroscopy 2007;61(6):579-84.
2007: Tomoyuki Koike; Shuichi Ohara; Hitoshi Sehine; Masashi Kawamura; Yasuhiko Abe; Yoshifumi Inomata; Katsunori Iijima; Akira Imatani; Tooru Shimosegawa
Effect of Helicobacter pylori status on intragastric pH during administration of lafutidine or famotidine.
Hepato-gastroenterology 2007;54(76):1280-4.
2007: K Asanuma; K Iijima; N Ara; T Koike; J Yoshitake; S Ohara; Tooru Shimosegawa; T Yoshimura
Fe-S cluster proteins are intracellular targets for nitric oxide generated luminally at the gastro-oesophageal junction.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2007;16(4):395-402.
2007: Atsushi Masamune; Kiyoshi Kume; Yasuhiko Takagi; Kazuhiro Kikuta; Kennichi Satoh; Akihiko Satoh; Tooru Shimosegawa
N34S mutation in the SPINK1 gene is not associated with alternative splicing.
Pancreas 2007;34(4):423-8.
2007: Tetsuhide Ito; Makoto Otsuki; Takao Itoi; Tooru Shimosegawa; Akihiro Funakoshi; Keiko Shiratori; Satoru Naruse; Yoshikazu Kuroda
Pancreatic diabetes in a follow-up survey of chronic pancreatitis in Japan.
Journal of gastroenterology 2007;42(4):291-7.
2007: Tomoyuki Koike; Shuichi Ohara; Yoshifumi Inomata; Yasuhiko Abe; Katsunori Iijima; Tooru Shimosegawa
The prevalence of Helicobacter pylori infection and the status of gastric acid secretion in patients with gastroesophageal junction adenocarcinoma in Japan.
Inflammopharmacology 2007;15(2):61-4.
2007: Yuki Moritoki; Yoshiyuki Ueno; Noriatsu Kanno; Yoko Yamagiwa; Koji Fukushima; M Eric Gershwin; Tooru Shimosegawa
Amniotic epithelial cell-derived cholangiocytes in experimental cholestatic ductal hyperplasia.
Hepatology research : the official journal of the Japan Society of Hepatology 2007;37(4):286-94.
2007: Kaichiro Yahagi; Yoshiyuki Ueno; Eiki Nomura; Koji Fukushima; Yuki Moritoki; Takayuki Kogure; Yasuhiro Kojima; Kenichi Negoro; Yoshitaka Kinouchi; Tooru Shimosegawa
Mapping of a disease susceptibility locus in the HLA region for Primary Biliary Cirrhosis in Japan.
Hepatology research : the official journal of the Japan Society of Hepatology 2007;37(4):270-5.
2007: Yoshiyuki Ueno; Yuki Moritoki; Tooru Shimosegawa; M Eric Gershwin
Primary biliary cirrhosis: what we know and what we want to know about human PBC and spontaneous PBC mouse models.
Journal of gastroenterology 2007;42(3):189-95.
2007: Kenji Kimura; Kennichi Satoh; Atsushi Kanno; Shin Hamada; Morihisa Hirota; Mareyuki Endoh; Atsushi Masamune; Tooru Shimosegawa
Activation of Notch signaling in tumorigenesis of experimental pancreatic cancer induced by dimethylbenzanthracene in mice.
Cancer science 2007;98(2):155-62.
2007: Masashi Kawamura; Shuichi Ohara; Tomoyuki Koike; Katsunori Iijima; Hitoshi Suzuki; Shoichi Kayaba; Kenji Noguchi; Shinya Abe; Mitsunori Noguchi; Tooru Shimosegawa
Cytochrome P450 2C19 polymorphism influences the preventive effect of lansoprazole on the recurrence of erosive reflux esophagitis.
Journal of gastroenterology and hepatology 2007;22(2):222-6.
2007: Masashi Ninomiya; Masaharu Takahashi; Tooru Shimosegawa; Hiroaki Okamoto
Analysis of the entire genomes of fifteen torque teno midi virus variants classifiable into a third group of genus Anellovirus.
Archives of virology 2007;152(11):1961-75.
2007: Atsushi Masamune; Kiyoshi Kume; Tooru Shimosegawa
Differential roles of the SPINK1 gene mutations in alcoholic and nonalcoholic chronic pancreatitis.
Journal of gastroenterology 2007;42 Suppl 17():135-40.
2007: Katsunori Iijima; Kiyotaka Asanuma; Shuichi Ohara; Tooru Shimosegawa
[Nitric oxide generated at gastro-oesophageal junction].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2007;104(1):17-22.
2006: Atsushi Kanno; Kennichi Satoh; Kenji Kimura; Morihisa Hirota; Jun Umino; Atsushi Masamune; Akihiko Satoh; Tohru Asakura; Shinichi Egawa; Makoto Sunamura; Mareyuki Endoh; Tooru Shimosegawa
The expression of MUC4 and MUC5AC is related to the biologic malignancy of intraductal papillary mucinous neoplasms of the pancreas.
Pancreas 2006;33(4):391-6.
2006: S Takagi; K Utsunomiya; S Kuriyama; H Yokoyama; S Takahashi; M Iwabuchi; H Takahashi; S Takahashi; Y Kinouchi; N Hiwatashi; Y Funayama; I Sasaki; I Tsuji; Tooru Shimosegawa
Effectiveness of an 'half elemental diet' as maintenance therapy for Crohn's disease: A randomized-controlled trial.
Alimentary pharmacology & therapeutics 2006;24(9):1333-40.
2006: Hitoshi Sekine; Katsunori Iijima; Tomoyuki Koike; Yasuhiko Abe; Akira Imatani; Katsuaki Kato; Shuichi Ohara; Tooru Shimosegawa
Regional differences in the recovery of gastric acid secretion after Helicobacter pylori eradication: evaluations with Congo red chromoendoscopy.
Gastrointestinal endoscopy 2006;64(5):678-85.
2006: Koji Fukushima; Yoshiyuki Ueno; Jun Inoue; Noriatsu Kanno; Tooru Shimosegawa
Filopodia formation via a specific Eph family member and PI3K in immortalized cholangiocytes.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(5):G812-9.
2006: Tooru Shimosegawa; Kiyoshi Kume; Atsushi Masamune
[Recent findings on chronic pancreatitis].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2006;95(10):2105-11.
2006: Eiki Nomura; Sho Takagi; Tatsuya Kikuchi; Kenichi Negoro; Seiichi Takahashi; Yoshitaka Kinouchi; Nobuo Hiwatashi; Tooru Shimosegawa
Efficacy and safety of endoscopic balloon dilation for Crohn's strictures.
Diseases of the colon and rectum 2006;49(10 Suppl):S59-67.
2006: Takayuki Kogure; Yoshiyuki Ueno; Naoki Kawagishi; Noriatsu Kanno; Yoko Yamagiwa; Koji Fukushima; Susumu Satomi; Tooru Shimosegawa
The model for end-stage liver disease score is useful for predicting economic outcomes in adult cases of living donor liver transplantation.
Journal of gastroenterology 2006;41(10):1005-10.
2006: Tooru Shimosegawa; Kiyoshi Kume; Atsushi Masamune
SPINK1 gene mutations and pancreatitis in Japan.
Journal of gastroenterology and hepatology 2006;21 Suppl 3():S47-51.
2006: Kazuhiro Kikuta; Atsushi Masamune; Masahiro Satoh; Noriaki Suzuki; Kennichi Satoh; Tooru Shimosegawa
Hydrogen peroxide activates activator protein-1 and mitogen-activated protein kinases in pancreatic stellate cells.
Molecular and cellular biochemistry 2006;291(1-2):11-20.
2006: Katsunori Iijima; Tooru Shimosegawa
Gastric carditis: Is it a histological response to high concentrations of luminal nitric oxide?
World journal of gastroenterology : WJG 2006;12(36):5767-71.
2006: Futoshi Nagasaki; Yoshiyuki Ueno; Takeshi Yamamoto; Yu Nakagomi; Osamu Kido; Eiji Kakazu; Yasunori Matsuda; Takayuki Kogure; Yoko Yamagiwa; Kumiko Kikuchi; Koji Fukushima; Noriatsu Kanno; Hirofumi Niitsuma; Tooru Shimosegawa
Sustained clinical improvement of a patient with decompensated hepatitis B virus-related cirrhosis after treatment with lamivudine monotherapy.
The Tohoku journal of experimental medicine 2006;210(1):29-36.
2006: Ken Ariizumi; Shuichi Ohara; Tomoyuki Koike; Yoshifumi Inomata; Katsunori Iijima; Hitoshi Sekine; Mitsunori Noguchi; Koichi Sugiyama; Yoshiki Eda; Shoichi Kayaba; Msashi Kawamura; Tooru Shimosegawa
Therapeutic effects of 10 mg/day rabeprazole administration on reflux esophagitis was not influenced by the CYP2C19 polymorphism.
Journal of gastroenterology and hepatology 2006;21(9):1428-34.
2006: Choitsu Sakamoto; Kentaro Sugano; Shinichi Ota; Nobuhiro Sakaki; Shin'ichi Takahashi; Yukio Yoshida; Taku Tsukui; Hiroyuki Osawa; Yukihiro Sakurai; Junji Yoshino; Yuji Mizokami; Tetsuya Mine; Tetsuo Arakawa; Hajime Kuwayama; Katsunori Saigenji; Koji Yakabi; Tsutomu Chiba; Tooru Shimosegawa; Jane E Sheehan; Susana Perez-Gutthann; Takuhiro Yamaguchi; David W Kaufman; Tsugumichi Sato; Kiyoshi Kubota; Akira Terano
Case-control study on the association of upper gastrointestinal bleeding and nonsteroidal anti-inflammatory drugs in Japan.
European journal of clinical pharmacology 2006;62(9):765-72.
2006: Akihiko Satoh; Anna S Gukovskaya; Joseph R Reeve; Tooru Shimosegawa; Stephen J Pandol
Ethanol sensitizes NF-kappaB activation in pancreatic acinar cells through effects on protein kinase C-epsilon.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(3):G432-8.
2006: Takayuki Kogure; Yoshiyuki Ueno; Noriatsu Kanno; Koji Fukushima; Yoko Yamagiwa; Futoshi Nagasaki; Eiji Kakazu; Yasunori Matsuda; Osamu Kido; Yu Nakagome; Masashi Ninomiya; Tooru Shimosegawa
Sustained viral response of a case of acute hepatitis C virus infection via needle-stick injury.
World journal of gastroenterology : WJG 2006;12(29):4757-60.
2006: Masaaki Shiina; Koju Kobayashi; Tomoo Kobayashi; Yasuteru Kondo; Yoshiyuki Ueno; Tooru Shimosegawa
Dynamics of immature subsets of dendritic cells during antiviral therapy in HLA-A24-positive chronic hepatitis C patients.
Journal of gastroenterology 2006;41(8):758-64.
2006: Jun Inoue; Masaharu Takahashi; Keiichi Ito; Tooru Shimosegawa; Hiroaki Okamoto
Analysis of human and swine hepatitis E virus (HEV) isolates of genotype 3 in Japan that are only 81-83 % similar to reported HEV isolates of the same genotype over the entire genome.
The Journal of general virology 2006;87(Pt 8):2363-9.
2006: Yasuteru Kondo; Koju Kobayashi; Yoshiyuki Ueno; Masaaki Shiina; Hirofumi Niitsuma; Noriatsu Kanno; Tomoo Kobayashi; Tooru Shimosegawa
Mechanism of T cell hyporesponsiveness to HBcAg is associated with regulatory T cells in chronic hepatitis B.
World journal of gastroenterology : WJG 2006;12(27):4310-7.
2006: Kazuichi Okazaki; Shigeyuki Kawa; Terumi Kamisawa; Satoru Naruse; Shigeki Tanaka; Isao Nishimori; Hirotaka Ohara; Tetsuhide Ito; Seiki Kiriyama; Kazuro Inui; Tooru Shimosegawa; Masaru Koizumi; Koichi Suda; Keiko Shiratori; Koji Yamaguchi; Taketo Yamaguchi; Masanori Sugiyama; Makoto Otsuki
Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal.
Journal of gastroenterology 2006;41(7):626-31.
2006: Makoto Otsuki; Masahiko Hirota; Shinju Arata; Masaru Koizumi; Shigeyuki Kawa; Terumi Kamisawa; Kazunori Takeda; Toshihiko Mayumi; Motoji Kitagawa; Tetsuhide Ito; Kazuo Inui; Tooru Shimosegawa; Shigeki Tanaka; Keisho Kataoka; Hiromitsu Saisho; Kazuichi Okazaki; Yosikazu Kuroda; Norio Sawabu; Yoshifumi Takeyama
Consensus of primary care in acute pancreatitis in Japan.
World journal of gastroenterology : WJG 2006;12(21):3314-23.
2006: Sho Takagi; Yoshitaka Kinouchi; Seiichi Takahashi; Tooru Shimosegawa
Hemodynamics of rectal varices.
Journal of gastroenterology 2006;41(6):611-2.
2006: Yasuhiro Nakamura; Norihiro Shimada; Takashi Suzuki; Akira Imatani; Hitoshi Sekine; Shuichi Ohara; Tooru Shimosegawa; Hironobu Sasano
In situ androgen production in human gastric carcinoma--androgen synthesizing and metabolizing enzymes.
Anticancer research 2006;26(3A):1935-9.
2006: Atsushi Kanno; Kennichi Satoh; Kenji Kimura; Atsushi Masamune; Tohru Asakura; Shinichi Egawa; Makoto Sunamura; Mika Watanabe; Tooru Shimosegawa
Acute pancreatitis due to pancreatic arteriovenous malformation: 2 case reports and review of the literature.
Pancreas 2006;32(4):422-5.
2006: Yuki Moritoki; Yoshiyuki Ueno; Noriatsu Kanno; Yoko Yamagiwa; Koji Fukushima; M Eric Gershwin; Tooru Shimosegawa
Lack of evidence that bone marrow cells contribute to cholangiocyte repopulation during experimental cholestatic ductal hyperplasia.
Liver international : official journal of the International Association for the Study of the Liver 2006;26(4):457-66.
2006: Futoshi Nagasaki; Hirofumi Niitsuma; Julieta G Cervantes; Masanori Chiba; Shan Hong; Toshiaki Ojima; Yoshiyuki Ueno; Edgardo Bondoc; Koju Kobayashi; Motoyasu Ishii; Tooru Shimosegawa
Analysis of the entire nucleotide sequence of hepatitis B virus genotype B in the Philippines reveals a new subgenotype of genotype B.
The Journal of general virology 2006;87(Pt 5):1175-80.
2006: Yoshifumi Inomata; Tomoyuki Koike; Shuichi Ohara; Yasuhiko Abe; Hitoshi Sekine; Katsunori Iijima; Ken Ariizumi; Hatsushi Yamagishi; Yasushi Kitagawa; Akira Imatani; Tooru Shimosegawa
Preservation of gastric acid secretion may be important for the development of gastroesophageal junction adenocarcinoma in Japanese people, irrespective of the H. pylori infection status.
The American journal of gastroenterology 2006;101(5):926-33.
2006: Takumi Shibuya; Kazuhide Watanabe; Hiroshi Yamashita; Kazue Shimizu; Hiroki Miyashita; Mayumi Abe; Takuya Moriya; Hideki Ohta; Hikaru Sonoda; Tooru Shimosegawa; Koichi Tabayashi; Yasufumi Sato
Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(5):1051-7.
2006: Yuichirou Sato; Seiichi Takahashi; Yoshitaka Kinouchi; Manabu Shiraki; Katsuya Endo; Yoshifumi Matsumura; Yoichi Kakuta; Masaki Tosa; Atsuhiro Motida; Hiroko Abe; Go Imai; Hiroshi Yokoyama; Eiki Nomura; Kenichi Negoro; Sho Takagi; Hiroyuki Aihara; Ken-ichi Masumura; Takehiko Nohmi; Tooru Shimosegawa
IL-10 deficiency leads to somatic mutations in a model of IBD.
Carcinogenesis 2006;27(5):1068-73.
2006: Jun Inoue; Tsutomu Nishizawa; Masaharu Takahashi; Tatsuya Aikawa; Hitoshi Mizuo; Kazuyuki Suzuki; Tooru Shimosegawa; Hiroaki Okamoto
Analysis of the full-length genome of genotype 4 hepatitis E virus isolates from patients with fulminant or acute self-limited hepatitis E.
Journal of medical virology 2006;78(4):476-84.
2006: Atsushi Masamune; Masahiro Satoh; Jun Hirabayashi; Kenichi Kasai; Kennichi Satoh; Tooru Shimosegawa
Galectin-1 induces chemokine production and proliferation in pancreatic stellate cells.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(4):G729-36.
2006: Atsushi Masamune; Noriaki Suzuki; Kazuhiro Kikuta; Masahiro Satoh; Kennichi Satoh; Tooru Shimosegawa
Curcumin blocks activation of pancreatic stellate cells.
Journal of cellular biochemistry 2006;97(5):1080-93.
2006: Keiichi Tamai; Koji Fukushima; Yoshiyuki Ueno; Yuki Moritoki; Yoko Yamagiwa; Noriatsu Kanno; Douglas M Jefferson; Tooru Shimosegawa
Differential expressions of aquaporin proteins in human cholestatic liver diseases.
Hepatology research : the official journal of the Japan Society of Hepatology 2006;34(2):99-103.
2006: Koju Kobayashi; Yoshiyuki Ueno; Yoshie Kobayashi; Takehiro Akahane; Shuichi Satoh; Kumiko Kikuchi; Hiromasa Okamoto; Motoyasu Ishii; Tooru Shimosegawa
Th1 response during ribavirin and interferon-alpha combination therapy in chronic hepatitis C.
Hepatology research : the official journal of the Japan Society of Hepatology 2006;34(2):104-10.
2006: Akira Terano; Tetsuo Arakawa; Toshiro Sugiyama; Toshikazu Yoshikawa; Ken Haruma; Masahiro Asaka; Tooru Shimosegawa; Nobuhiro Sakaki; Hiromasa Ishii; Choitsu Sakamoto; Shin-Ichi Takahashi; Yoshikazu Kinoshita; Toshio Fujioka; Kenzo Kobayashi
A pilot study to evaluate a new combination therapy for gastric ulcer: Helicobacter pylori eradication therapy followed by gastroprotective treatment with rebamipide.
Journal of gastroenterology and hepatology 2006;21(1 Pt 1):103-9.
2006: Kennichi Satoh; Tooru Shimosegawa
[Diagnosis of pancreatic cancer from laboratory data].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 1():140-3.
2006: Masaki Tosa; Kenichi Negoro; Yoshitaka Kinouchi; Hiroko Abe; Eiki Nomura; Sho Takagi; Hiroyuki Aihara; Shinya Oomori; Mikako Sugimura; Kazuma Takahashi; Nobuo Hiwatashi; Seiichi Takahashi; Tooru Shimosegawa
Lack of association between IBD5 and Crohn's disease in Japanese patients demonstrates population-specific differences in inflammatory bowel disease.
Scandinavian journal of gastroenterology 2006;41(1):48-53.
2005: Shin Hamada; Kennichi Satoh; Kenji Kimura; Atsushi Kanno; Atsushi Masamune; Tooru Shimosegawa
MSX2 overexpression inhibits gemcitabine-induced caspase-3 activity in pancreatic cancer cells.
World journal of gastroenterology : WJG 2005;11(43):6867-70.
2005: Tomoyuki Koike; Shuichi Ohara; Katsunori Lijima; Hitoshi Sekine; Tooru Shimosegawa
[Development of reflux esophagitis after H. pylori eradication].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 11():495-8.
2005: Motoki Ohyauchi; Akira Imatani; Shuichi Ohara; Tooru Shimosegawa
[Effects of the interleukin-8 -251A/T polymorphism on the transcriptional activity and gastric atrophy in Helicobacter pylori infection].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 11():89-92.
2005: Atsushi Kanno; Kennichi Satoh; Kenji Kimura; Atsushi Masamune; Tohru Asakura; Michiaki Unno; Seiki Matsuno; Takuya Moriya; Tooru Shimosegawa
Autoimmune pancreatitis with hepatic inflammatory pseudotumor.
Pancreas 2005;31(4):420-3.
2005: Atsushi Masamune; Masahiro Satoh; Kazuhiro Kikuta; Noriaki Suzuki; Tooru Shimosegawa
Endothelin-1 stimulates contraction and migration of rat pancreatic stellate cells.
World journal of gastroenterology : WJG 2005;11(39):6144-51.
2005: Katsunori Iijima; Hitoshi Sekine; Tomoyuki Koike; Akira Imatani; Shuichi Ohara; Tooru Shimosegawa
Serum pepsinogen concentrations as a measure of gastric acid secretion in Helicobacter pylori-negative and -positive Japanese subjects.
Journal of gastroenterology 2005;40(10):938-44.
2005: Atsushi Masamune; Masahiro Satoh; Kazuhiro Kikuta; Noriaki Suzuki; Kennichi Satoh; Tooru Shimosegawa
Ellagic acid blocks activation of pancreatic stellate cells.
Biochemical pharmacology 2005;70(6):869-78.
2005: Kenji Kimura; Tooru Shimosegawa
[Gastric inhibitory polypeptide (GIP)].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 8():528-31.
2005: Kenji Kimura; Tooru Shimosegawa
[Neurotensin].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 8():244-7.
2005: Shuichi Ohara; Tomoyuki Koike; Hitoshi Sekine; Katsunori Iijima; Tooru Shimosegawa
[Endoscopic therapy for Barrett's esophagus].
Nihon rinsho. Japanese journal of clinical medicine 2005;63(8):1438-42.
2005: Akihiko Satoh; Anna S Gukovskaya; Mouad Edderkaoui; Melissa S Daghighian; Joseph R Reeve; Tooru Shimosegawa; Stephen J Pandol
Tumor necrosis factor-alpha mediates pancreatitis responses in acinar cells via protein kinase C and proline-rich tyrosine kinase 2.
Gastroenterology 2005;129(2):639-51.
2005: K Asanuma; K Iijima; Hideaki Sugata; S Ohara; Tooru Shimosegawa; Tetsuhiko Yoshimura
Diffusion of cytotoxic concentrations of nitric oxide generated luminally at the gastro-oesophageal junction of rats.
Gut 2005;54(8):1072-7.
2005: Koju Kobayashi; M Ishii; Masaaki Shiina; Yoshiyuki Ueno; Yasuteru Kondo; A Kanno; Y Miyazaki; T Yamamoto; Tomoo Kobayashi; Hirofumi Niitsuma; Y Kikumoto; H Takizawa; Tooru Shimosegawa
Interferon-gamma is produced by CD8 T cells in response to HLA-A24-restricted hepatitis C virus epitopes after sustained virus loss.
Clinical and experimental immunology 2005;141(1):81-8.
2005: Jun Inoue; Masaharu Takahashi; Tsutomu Nishizawa; Luvsanbasaryn Narantuya; Mitsuru Sakuma; Yasuo Kagawa; Tooru Shimosegawa; Hiroaki Okamoto
High prevalence of hepatitis delta virus infection detectable by enzyme immunoassay among apparently healthy individuals in Mongolia.
Journal of medical virology 2005;76(3):333-40.
2005: Atsushi Masamune; Masahiro Satoh; Kazuhiro Kikuta; Noriaki Suzuki; Tooru Shimosegawa
Activation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic stellate cells.
World journal of gastroenterology : WJG 2005;11(22):3385-91.
2005: Atsushi Masamune; Kazuhiro Kikuta; Masahiro Satoh; Noriaki Suzuki; Tooru Shimosegawa
Green tea polyphenol epigallocatechin-3-gallate blocks PDGF-induced proliferation and migration of rat pancreatic stellate cells.
World journal of gastroenterology : WJG 2005;11(22):3368-74.
2005: Futoshi Nagasaki; Yoshiyuki Ueno; Noriatsu Kanno; Hiroaki Okamoto; Tooru Shimosegawa
A case of acute hepatitis with positive autoantibodies who actually had hepatitis E virus infection.
Hepatology research : the official journal of the Japan Society of Hepatology 2005;32(2):134-7.
2005: Futoshi Nagasaki; Yoshiyuki Ueno; Yutaka Mano; Takehiko Igarashi; Kaichiro Yahagi; Hirofumi Niitsuma; Hiroaki Okamoto; Tooru Shimosegawa
A patient with clinical features of acute hepatitis E viral infection and autoimmune hepatitis.
The Tohoku journal of experimental medicine 2005;206(2):173-9.
2005: Shinya Oomori; Sho Takagi; Tatsuya Kikuchi; K Utsunomiya; H Yokoyama; Kenichi Negoro; Yasuo Tohmiya; Hiroyuki Aihara; M Yamada; Seiichi Takahashi; J Kameoka; Yoshitaka Kinouchi; Tooru Shimosegawa
Significance of colonoscopy in patients with intestinal graft-versus-host disease after hematopoietic stem cell transplantation.
Endoscopy 2005;37(4):346-50.
2005: Yoshitaka Kinouchi; Kenichi Negoro; Sho Takagi; Seiichi Takahashi; Tooru Shimosegawa
Genotype and phenotype relation in inflammatory bowel disease.
Journal of gastroenterology 2005;40 Suppl 16():21-4.
2005: Motoki Ohyauchi; Akira Imatani; Makoto Yonechi; N Asano; A Miura; K Iijima; Tomoyuki Koike; Hitoshi Sekine; Shuichi Ohara; Tooru Shimosegawa
The polymorphism interleukin 8 -251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population.
Gut 2005;54(3):330-5.
2005: Yasushi Ishigaki; Hideki Katagiri; Tetsuya Yamada; Takehide Ogihara; Junta Imai; Kenji Uno; Yutaka Hasegawa; Junhong Gao; Hisamitsu Ishihara; Tooru Shimosegawa; Hideyuki Sakoda; Tomoichiro Asano; Yoshitomo Oka
Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity.
Diabetes 2005;54(2):322-32.
2005: Jun Inoue; Yoshiyuki Ueno; Noriatsu Kanno; Hideaki Anzai; Yasuteru Kondo; Yuki Moritoki; Emiko Mikami; Masanori Chiba; Takayuki Kogure; Futoshi Nagasaki; Koji Fukushima; Takao Iwasaki; Susumu Satomi; Tooru Shimosegawa
Living related liver transplantation for acute fulminant hepatitis B: experience from two possible hyper-acute cases.
The Tohoku journal of experimental medicine 2005;205(2):197-204.
2005: Atsushi Masamune; Kazuhiro Kikuta; Masahiro Satoh; Noriaki Suzuki; Tooru Shimosegawa
Protease-activated receptor-2-mediated proliferation and collagen production of rat pancreatic stellate cells.
The Journal of pharmacology and experimental therapeutics 2005;312(2):651-8.
2005: Kiyoshi Kume; Atsushi Masamune; Hiroya Mizutamari; Kenzo Kaneko; Kazuhiro Kikuta; Masahiro Satoh; Kennichi Satoh; Kenji Kimura; Noriaki Suzuki; Yutaka Nagasaki; Akira Horii; Tooru Shimosegawa
Mutations in the serine protease inhibitor Kazal Type 1 (SPINK1) gene in Japanese patients with pancreatitis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2005;5(4-5):354-60.
2005: Seiichi Kato; Kyoko Ozawa; Hitoshi Sekine; Motoki Ohyauchi; Tooru Shimosegawa; Takanori Minoura; Kazuie Iinuma
Helicobacter heilmannii infection in a child after successful eradication of Helicobacter pylori: case report and review of literature.
Journal of gastroenterology 2005;40(1):94-7.
2005: Tooru Shimosegawa; Atsushi Masamune; Kiyoshi Kume
[Prospective review of treatment for chronic pancreatitis: genetic background and control of pancreatic fibrosis].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2005;102(1):1-9.
2005: Motoji Oki; Haruo Ohtani; Yoshitaka Kinouchi; Eiichi Sato; Shiro Nakamura; Takayuki Matsumoto; Hiroshi Nagura; Osamu Yoshie; Tooru Shimosegawa
Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response?
Laboratory investigation; a journal of technical methods and pathology 2005;85(1):137-45.
2004: Nozomu Sano; Shuichi Ohara; Tomoyuki Koike; Hitoshi Sekine; Akira Imatani; Yasushi Kitagawa; Naohiro Dairaku; Katsunori Iijima; Katsuaki Kato; Tooru Shimosegawa
[Influence of urease activity of the oral cavity and oropharynx on 13C-urea breath test].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2004;101(12):1302-8.
2004: Yasuteru Kondo; Koju Kobayashi; S Asabe; Masaaki Shiina; Hirofumi Niitsuma; Yoshiyuki Ueno; Tomoo Kobayashi; Tooru Shimosegawa
Vigorous response of cytotoxic T lymphocytes associated with systemic activation of CD8 T lymphocytes in fulminant hepatitis B.
Liver international : official journal of the International Association for the Study of the Liver 2004;24(6):561-7.
2004: Atsushi Masamune; Tooru Shimosegawa
[Anti-cytokine therapy for severe acute pancreatitis].
Nihon rinsho. Japanese journal of clinical medicine 2004;62(11):2116-21.
2004: Manabu Shiraki; Hiroyuki Aihara; Yoshitaka Kinouchi; Seiichi Takahashi; Motoji Oki; Mitsunori Noguchi; Kazuma Takahashi; Jun-Ichi Miyazaki; Tooru Shimosegawa
IL-12 p40 prevents the development of chronic enterocolitis in IL-10-deficient mice.
Laboratory investigation; a journal of technical methods and pathology 2004;84(11):1491-500.
2004: Yasuteru Kondo; Shinichi Asabe; Koju Kobayashi; Masaaki Shiina; Hirofumi Niitsuma; Yoshiyuki Ueno; Tomoo Kobayashi; Tooru Shimosegawa
Recovery of functional cytotoxic T lymphocytes during lamivudine therapy by acquiring multi-specificity.
Journal of medical virology 2004;74(3):425-33.
2004: Manabu Shiraki; Sho Takagi; Kouichi Sugiyama; Takao Iwasaki; Hiroyuki Aihara; Seiichi Takahashi; Yoshitaka Kinouchi; Nobuo Hiwatashi; Tooru Shimosegawa
Rupture of rectal varices treated with endoscopic variceal ligation.
Surgical laparoscopy, endoscopy & percutaneous techniques 2004;14(5):295-9.
2004: Tetsuya Ono; Hironobu Ikehata; Vishnu Priya Pithani; Yoshihiko Uehara; Yali Chen; Yoshitaka Kinouchi; Tooru Shimosegawa; Yoshio Hosoi
Spontaneous mutations in digestive tract of old mice show tissue-specific patterns of genomic instability.
Cancer research 2004;64(19):6919-23.
2004: Eiki Nomura; Yoshitaka Kinouchi; Kenichi Negoro; Yasuhiro Kojima; Shinya Oomori; Mikako Sugimura; M Hiroki; Sho Takagi; Hiroyuki Aihara; Seiichi Takahashi; Nobuo Hiwatashi; Tooru Shimosegawa
Mapping of a disease susceptibility locus in chromosome 6p in Japanese patients with ulcerative colitis.
Genes and immunity 2004;5(6):477-83.
2004: Akihiko Satoh; Anna S Gukovskaya; Jose M Nieto; Jason H Cheng; Ilya Gukovsky; Joseph R Reeve; Tooru Shimosegawa; Stephen J Pandol
PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells.
American journal of physiology. Gastrointestinal and liver physiology 2004;287(3):G582-91.
2004: Kazuhiro Kikuta; Atsushi Masamune; Masahiro Satoh; Noriaki Suzuki; Tooru Shimosegawa
4-hydroxy-2, 3-nonenal activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells.
World journal of gastroenterology : WJG 2004;10(16):2344-51.
2004: Atsushi Masamune; Kazuhiro Kikuta; Noriaki Suzuki; Masahiro Satoh; Kennichi Satoh; Tooru Shimosegawa
A c-Jun NH2-terminal kinase inhibitor SP600125 (anthra[1,9-cd]pyrazole-6 (2H)-one) blocks activation of pancreatic stellate cells.
The Journal of pharmacology and experimental therapeutics 2004;310(2):520-7.
2004: Eiki Nomura; Sho Takagi; Ryo Ichinohasama; Tatsuya Kikuchi; Manabu Shiraki; Shinya Oomori; Hiroshi Yokoyama; Kyoko Utsunomiya; Kenichi Negoro; Hiroyuki Aihara; Seiichi Takahashi; Yoshitaka Kinouchi; Tooru Shimosegawa
Multiparameter analysis for discreet differential diagnosis of mucosa-associated lymphoid tissue lymphoma in the intestine.
In vivo (Athens, Greece) 2004;18(4):437-41.
2004: Yasuhiko Abe; Shuichi Ohara; Tomoyuki Koike; Hitoshi Sekine; Katsunori Iijima; Masashi Kawamura; Akira Imatani; Katsuaki Kato; Tooru Shimosegawa
The prevalence of Helicobacter pylori infection and the status of gastric acid secretion in patients with Barrett's esophagus in Japan.
The American journal of gastroenterology 2004;99(7):1213-21.
2004: Katsunori Iijima; Hitoshi Sekine; Tomoyuki Koike; Akira Imatani; Shuichi Ohara; Tooru Shimosegawa
Long-term effect of Helicobacter pylori eradication on the reversibility of acid secretion in profound hypochlorhydria.
Alimentary pharmacology & therapeutics 2004;19(11):1181-8.
2004: Kaname Uno; Yoshihito Iuchi; Junichi Fujii; Hideaki Sugata; Katsunori Iijima; Katsuaki Kato; Tooru Shimosegawa; Tetsuhiko Yoshimura
In vivo study on cross talk between inducible nitric-oxide synthase and cyclooxygenase in rat gastric mucosa: effect of cyclooxygenase activity on nitric oxide production.
The Journal of pharmacology and experimental therapeutics 2004;309(3):995-1002.
2004: Masaaki Shiina; Koju Kobayashi; Hiroko Satoh; Hirofumi Niitsuma; Yoshiyuki Ueno; Tooru Shimosegawa
Ribavirin upregulates interleukin-12 receptor and induces T cell differentiation towards type 1 in chronic hepatitis C.
Journal of gastroenterology and hepatology 2004;19(5):558-64.
2004: Norihiro Shimada; Takashi Suzuki; Satoshi Inoue; Katsuaki Kato; Akira Imatani; Hitoshi Sekine; Shuichi Ohara; Tooru Shimosegawa; Hironobu Sasano
Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues.
Molecular and cellular endocrinology 2004;218(1-2):147-53.
2004: Manabu Shiraki; Sho Takagi; Mika Watanabe; Yuichirou Sato; Seiichi Takahashi; Yoshitaka Kinouchi; Seiichi Ishii; Takayuki Mizoi; Ken-ichi Shiiba; Iwao Sasaki; Tooru Shimosegawa
Panniculitis of the descending colon caused by enterocolic phlebitis: a case report.
The Tohoku journal of experimental medicine 2004;202(4):299-304.
2004: Atsushi Masamune; Hiroya Mizutamari; Kiyoshi Kume; Tooru Asakura; Kennichi Satoh; Tooru Shimosegawa
Hereditary pancreatitis as the premalignant disease: a Japanese case of pancreatic cancer involving the SPINK1 gene mutation N34S.
Pancreas 2004;28(3):305-10.
2004: Takayuki Kogure; Yoshiyuki Ueno; Takao Iwasaki; Tooru Shimosegawa
The efficacy of the combination therapy of 5-fluorouracil, cisplatin and leucovorin for hepatocellular carcinoma and its predictable factors.
Cancer chemotherapy and pharmacology 2004;53(4):296-304.
2004: Tomoyuki Koike; Shuichi Ohara; Hitoshi Sekine; Katsunori Iijima; Ken Ariizumi; Yoshifumi Inomata; Yasushi Kitagawa; Naohiro Dairaku; Akira Imatani; Katsuaki Kato; Tooru Shimosegawa
[Reflux esophagitis after H. pylori eradication].
Nihon rinsho. Japanese journal of clinical medicine 2004;62(3):499-504.
2004: Akira Imatani; Shuichi Ohara; Makoto Yonechi; Motoki Ohyauchi; Tooru Shimosegawa
[Helicobacter pylori-related cytokines influence gastric acid secretion and gastric mucosal inflammation in gastroduodenal ulcers].
Nihon rinsho. Japanese journal of clinical medicine 2004;62(3):442-7.
2004: Makoto Otsuki; Isao Nishimori; Tetsuo Hayakawa; Masahiko Hirota; Michios Ogawa; Tooru Shimosegawa
Hereditary pancreatitis: clinical characteristics and diagnostic criteria in Japan.
Pancreas 2004;28(2):200-6.
2004: Naohiro Dairaku; Katsuaki Kato; Kennichi Honda; Tomoyuki Koike; Katsunori Iijima; Akira Imatani; Hitoshi Sekine; Shuichi Ohara; Hiroshi Matsui; Tooru Shimosegawa
Oligomycin and antimycin A prevent nitric oxide-induced apoptosis by blocking cytochrome C leakage.
The Journal of laboratory and clinical medicine 2004;143(3):143-51.
2004: Tooru Shimosegawa; Atsushi Masamune; Kenji Kimura
[Evidence-based clinical guidelines for acute pancreatitis--diagnosis of the severity].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2004;93(1):10-5.
2004: Yuuji Kubota; Katsuaki Kato; Naohiro Dairaku; Tomoyuki Koike; Katsunori Iijima; Akira Imatani; Hitoshi Sekine; Shuichi Ohara; Hiroshi Matsui; Tooru Shimosegawa
Contribution of glutamine synthetase to ammonia-induced apoptosis in gastric mucosal cells.
Digestion 2004;69(3):140-8.
2004: Tetsuya Yamagiwa; Tooru Shimosegawa; Akihiko Satoh; Kenji Kimura; Yoshitaka Sakai; Atsushi Masamune
Inosine alleviates rat caerulein pancreatitis and pancreatitis-associated lung injury.
Journal of gastroenterology 2004;39(1):41-9.
2004: Yutaka Konno; Katsuaki Kato; Naohiro Dairaku; Tomoyuki Koike; Katsunori Iijima; Akira Imatani; Hitoshi Sekine; Shuichi Ohara; Tooru Shimosegawa
Expression of Mg2+-dependent, HCO3- -stimulated adenine triphosphatase in the human duodenum.
Journal of gastroenterology and hepatology 2004;19(1):18-23.
2003: Yoshiyuki Ueno; Gianfranco Alpini; Kaichiro Yahagi; Noriatsu Kanno; Yuki Moritoki; Koji Fukushima; Shannon Glaser; Gene Lesage; Tooru Shimosegawa
Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice.
Liver international : official journal of the International Association for the Study of the Liver 2003;23(6):449-59.
2003: Kenichi Honda; Katsuaki Kato; Naohiro Dairaku; Katsunori Iijima; Tomoyuki Koike; Akira Imatani; Hitoshi Sekine; Shuichi Ohara; Hiroshi Matsui; Tooru Shimosegawa
High levels of intracellular ATP prevent nitric oxide-induced apoptosis in rat gastric mucosal cells.
International journal of experimental pathology 2003;84(6):281-8.
2003: Atsushi Masamune; Masahiro Satoh; Kazuhiro Kikuta; Noriaki Suzuki; Tooru Shimosegawa
Establishment and characterization of a rat pancreatic stellate cell line by spontaneous immortalization.
World journal of gastroenterology : WJG 2003;9(12):2751-8.
2003: Hisanobu Adachi; Takehiro Suzuki; Michiaki Abe; Naoki Asano; Hiroya Mizutamari; Masayuki Tanemoto; Toshiyuki Nishio; Tohru Onogawa; Takafumi Toyohara; Satoshi Kasai; Fumitoshi Satoh; Masanori Suzuki; Taro Tokui; Michiaki Unno; Tooru Shimosegawa; Seiki Matsuno; Sadayoshi Ito; Takaaki Abe
Molecular characterization of human and rat organic anion transporter OATP-D.
American journal of physiology. Renal physiology 2003;285(6):F1188-97.
2003: Atsushi Masamune; Kazuhiro Kikuta; Mashiro Satoh; Kennichi Satoh; Tooru Shimosegawa
Rho kinase inhibitors block activation of pancreatic stellate cells.
British journal of pharmacology 2003;140(7):1292-302.
2003: Maki Sugai; Masaki Saito; Izumi Sukegawa; Yuriko Katsushima; Yoshitaka Kinouchi; Norimichi Nakahata; Tooru Shimosegawa; Teruyuki Yanagisawa; Jun Sukegawa
PTH/PTH-related protein receptor interacts directly with Tctex-1 through its COOH terminus.
Biochemical and biophysical research communications 2003;311(1):24-31.
2003: Jing Yang; Katsuaki Kato; Kenji Noguchi; Naohiro Dairaku; Tomoyuki Koike; Katsunori Iijima; Akira Imatani; Hitoshi Sekine; Shuichi Ohara; Hironobu Sasano; Tooru Shimosegawa
Tochu (Eucommia ulmoides) leaf extract prevents ammonia and vitamin C deficiency induced gastric mucosal injury.
Life sciences 2003;73(25):3245-56.
2003: Tatsuya Kikuchi; Tohru Asakura; Hiroyuki Aihara; Manabu Shiraki; Sho Takagi; Yoshitaka Kinouchi; Katsuo Aizawa; Tooru Shimosegawa
Photodynamic therapy of intestinal tumors with mono-L-aspartyl chlorin e6 (NPe6): a basic study.
Anticancer research 2003;23(6C):4897-900.
2003: Sho Takagi; Yoshitaka Kinouchi; Masaki Chida; Nobuo Hiwatashi; Mitsunori Noguchi; Seiichi Takahashi; Tooru Shimosegawa
Strong telomerase activity of B lymphocyte from mesenteric lymph nodes of patients with inflammatory bowel disease.
Digestive diseases and sciences 2003;48(10):2091-4.
2003: Yasuteru Kondo; Koju Kobayashi; Tomoo Kobayashi; Masaaki Shiina; Yoshiyuki Ueno; Takaomi Satoh; Tooru Shimosegawa
Distribution of the HLA class I allele in chronic hepatitis C and its association with serum ALT level in chronic hepatitis C.
The Tohoku journal of experimental medicine 2003;201(2):109-17.
2003: Tooru Shimosegawa
[Alcoholic pancreatic injury].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2003;100(10):1198-205.
2003: Yoshitaka Kinouchi; Keisuke Matsumoto; Kenichi Negoro; Sho Takagi; Seiichi Takahashi; Nobuo Hiwatashi; Tooru Shimosegawa
Hla-B genotype in Japanese patients with Crohn's disease.
Diseases of the colon and rectum 2003;46(10 Suppl):S10-4.
2003: Takehiro Suzuki; Tohru Onogawa; Naoki Asano; Hiroya Mizutamari; Tsuyoshi Mikkaichi; Masayuki Tanemoto; Michiaki Abe; Fumitoshi Satoh; Michiaki Unno; Kazuo Nunoki; Masanori Suzuki; Takanori Hishinuma; Junichi Goto; Tooru Shimosegawa; Seiki Matsuno; Sadayoshi Ito; Takaaki Abe
Identification and characterization of novel rat and human gonad-specific organic anion transporters.
Molecular endocrinology (Baltimore, Md.) 2003;17(7):1203-15.
2003: Mitsunori Noguchi; Susumu Hara; Shigeru Tanda; Katsuo Sugiyama; Yukio Kaku; Seiichi Takahashi; Yoshitaka Kinouchi; Tooru Shimosegawa
[Cytomegalovirus colitis in a patient with severe refractory ulcerative colitis].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2003;92(5):862-4.
2003: Wakako Kawabata; Takashi Suzuki; Takuya Moriya; Keisei Fujimori; Hiroshi Naganuma; Satoshi Inoue; Yositaka Kinouchi; Kaori Kameyama; Hiroshi Takami; Tooru Shimosegawa; Hironobu Sasano
Estrogen receptors (alpha and beta) and 17beta-hydroxysteroid dehydrogenase type 1 and 2 in thyroid disorders: possible in situ estrogen synthesis and actions.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2003;16(5):437-44.
2003: Akihiko Satoh; Atsushi Masamune; Kenji Kimura; Kenzo Kaneko; Yoshitaka Sakai; Tetsuya Yamagiwa; Masahiro Satoh; Kazuhiro Kikuta; Tohru Asakura; Tooru Shimosegawa
Nuclear factor kappa B expression in peripheral blood mononuclear cells of patients with acute pancreatitis.
Pancreas 2003;26(4):350-6.
2003: Masashi Kawamura; Shuichi Ohara; Tomoyuki Koike; Katsunori Iijima; J Suzuki; Shoichi Kayaba; Kenji Noguchi; S Hamada; Mitsunori Noguchi; Tooru Shimosegawa
The effects of lansoprazole on erosive reflux oesophagitis are influenced by CYP2C19 polymorphism.
Alimentary pharmacology & therapeutics 2003;17(7):965-73.
2003: Yoshitaka Sakai; Atsushi Masamune; Akihiko Satoh; Jun Nishihira; Tetsuya Yamagiwa; Tooru Shimosegawa
Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis.
Gastroenterology 2003;124(3):725-36.
2003: Atsushi Masamune; Kazuhiro Kikuta; Masahiro Satoh; Kiyoshi Kume; Tooru Shimosegawa
Differential roles of signaling pathways for proliferation and migration of rat pancreatic stellate cells.
The Tohoku journal of experimental medicine 2003;199(2):69-84.
2003: Hideaki Sugata; Takaharu Ueno; Tooru Shimosegawa; Tetsuhiko Yoshimura
Direct detection of nitric oxide and its roles in maintaining gastric mucosal integrity following ethanol-induced injury in rats.
Free radical research 2003;37(2):159-69.
2003: Nobuya Obana; Sho Takagi; Yoshitaka Kinouchi; Yoshihisa Tokita; Akihiro Sekikawa; Seiichi Takahashi; Nobuo Hiwatashi; Shinichi Oikawa; Tooru Shimosegawa
Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders.
Internal medicine (Tokyo, Japan) 2003;42(2):150-3.
2003: Mikako Sugimura; Yoshitaka Kinouchi; Seiichi Takahashi; Hiroyuki Aihara; Sho Takagi; Kenichi Negoro; Nobuya Obana; Y Kojima; K Matsumoto; T Kikuchi; M Hiroki; Shinya Oomori; Tooru Shimosegawa
CARD15/NOD2 mutational analysis in Japanese patients with Crohn's disease.
Clinical genetics 2003;63(2):160-2.
2003: Nobuo Takano; Yuji Owada; Ryoji Suzuki; Hiroyuki Sakagami; Tooru Shimosegawa; Hisatake Kondo
Cloning and characterization of a novel variant (mM-rdgBbeta1) of mouse M-rdgBs, mammalian homologs of Drosophila retinal degeneration B gene proteins, and its mRNA localization in mouse brain in comparison with other M-rdgBs.
Journal of neurochemistry 2003;84(4):829-39.
2003: Tatsuo Oriuchi; Nobuo Hiwatashi; Yoshitaka Kinouchi; Seiichi Takahashi; Sho Takagi; Kenichi Negoro; Tooru Shimosegawa
Clinical course and longterm prognosis of Japanese patients with Crohn's disease: predictive factors, rates of operation, and mortality.
Journal of gastroenterology 2003;38(10):942-53.
2003: Seiichi Takahashi; Yasuhiro Kojima; Yoshitaka Kinouchi; Kenichi Negoro; Sho Takagi; Hiroyuki Aihara; Nobuya Obana; Keisuke Matsumoto; Nobuo Hiwatashi; Tooru Shimosegawa
Microsatellite instability and loss of heterozygosity in the nondysplastic colonic epithelium of ulcerative colitis.
Journal of gastroenterology 2003;38(8):734-9.
2003: Atsushi Masamune; Masahiro Satoh; Kazuhiro Kikuta; Yoshitaka Sakai; Akihiko Satoh; Tooru Shimosegawa
Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells.
The Journal of pharmacology and experimental therapeutics 2003;304(1):8-14.
2002: Kaichiro Yahagi; Yoshiyuki Ueno; Yutaka Mano; Tooru Shimosegawa
Rhabdomyolytic syndrome during the lamivudine therapy for acute exacerbation of chronic type B hepatitis.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2002;8(12):1198-9.
2002: Sho Takagi; Shinji Kumagai; Yoshitaka Kinouchi; Nobuo Hiwatashi; Fumio Nagashima; Seiichi Takahashi; Tooru Shimosegawa
High Ki-67 labeling index in human colorectal cancer with microsatellite instability.
Anticancer research 2002;22(6A):3241-4.
2002: Akihiko Satoh; Toshihiko Miura; Kennichi Satoh; Atsushi Masamune; Tetsuya Yamagiwa; Yoshitaka Sakai; Kazuhiko Shibuya; Kazunori Takeda; Mitsuo Kaku; Tooru Shimosegawa
Human leukocyte antigen-DR expression on peripheral monocytes as a predictive marker of sepsis during acute pancreatitis.
Pancreas 2002;25(3):245-50.
2002: Sho Takagi; Yoshitaka Kinouchi; Nobuo Hiwatashi; Masashi Hirai; Susumu Suzuki; Seiichi Takahashi; Kenichi Negoro; Nobuya Obana; Tooru Shimosegawa
Correlative polymorphism of NAD(P)H: quinone oxidoreductase (NQO1) with telomere shortening in colorectal cancer.
Anticancer research 2002;22(5):2749-52.
2002: Masahiro Satoh; Atsushi Masamune; Yoshitaka Sakai; Kazuhiro Kikuta; Hirofumi Hamada; Tooru Shimosegawa
Establishment and characterization of a simian virus 40-immortalized rat pancreatic stellate cell line.
The Tohoku journal of experimental medicine 2002;198(1):55-69.
2002: Atsushi Masamune; Yoshitaka Sakai; Kazuhiro Kikuta; Masahiro Satoh; Akihiko Satoh; Tooru Shimosegawa
Activated rat pancreatic stellate cells express intercellular adhesion molecule-1 (ICAM-1) in vitro.
Pancreas 2002;25(1):78-85.
2002: Nagamu Inoue; Kazuo Tamura; Yoshitaka Kinouchi; Yoshihiro Fukuda; Seiichi Takahashi; Yasunori Ogura; Naohiro Inohara; Gabriel Núñez; Yusuke Kishi; Yuji Koike; Tooru Shimosegawa; Takashi Shimoyama; Toshifumi Hibi
Lack of common NOD2 variants in Japanese patients with Crohn's disease.
Gastroenterology 2002;123(1):86-91.
2002: Atsushi Masamune; Kazuhiro Kikuta; Masahiro Satoh; Akihiko Satoh; Tooru Shimosegawa
Alcohol activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells.
The Journal of pharmacology and experimental therapeutics 2002;302(1):36-42.
2002: Nobuya Obana; Seiichi Takahashi; Yoshitaka Kinouchi; Kenichi Negoro; Sho Takagi; Nobuo Hiwatashi; Tooru Shimosegawa
Ulcerative colitis is associated with a promoter polymorphism of lipopolysaccharide receptor gene, CD14.
Scandinavian journal of gastroenterology 2002;37(6):699-704.
2002: Masaaki Shiina; Koju Kobayashi; Yutaka Mano; Yoshiyuki Ueno; Motoyasu Ishii; Tooru Shimosegawa
Up-regulation of CD11a (LFA-1) expression on peripheral CD4+ T cells in primary biliary cirrhosis.
Digestive diseases and sciences 2002;47(6):1209-15.
2002: Makoto Otsuki; Seiki Matsuno; Tooru Shimosegawa; John Williams; Vay Liang W Go
International symposium: mechanism of pancreatitis--between bedside and laboratory.
Pancreas 2002;24(4):391-407.
2002: Tatsuhiko Suzuki; Katsuaki Kato; Shuichi Ohara; Kenji Noguchi; Hitoshi Sekine; Hiroshi Nagura; Tooru Shimosegawa
Localization of antigen-presenting cells in Helicobacter pylori-infected gastric mucosa.
Pathology international 2002;52(4):265-71.
2002: Kenzo Kaneko; Kennichi Satoh; Atsushi Masamune; Akihiko Satoh; Tooru Shimosegawa
Expression of ROCK-1 in human pancreatic cancer: its down-regulation by morpholino oligo antisense can reduce the migration of pancreatic cancer cells in vitro.
Pancreas 2002;24(3):251-7.
2002: Masahiro Iwabuchi; Mareyuki Endoh; Nobuo Hiwatashi; Yoshitaka Kinouchi; Tooru Shimosegawa; Takayuki Masuda; Takuya Moriya; Hironobu Sasano
Three-dimensional reconstruction and fractal geometric analysis of serrated adenoma.
Japanese journal of cancer research : Gann 2002;93(3):259-66.
2002: Atsushi Masamune; Kenichi Satoh; Yoshitaka Sakai; Masayoshi Yoshida; Akihiko Satoh; Tooru Shimosegawa
Ligands of peroxisome proliferator-activated receptor-gamma induce apoptosis in AR42J cells.
Pancreas 2002;24(2):130-8.
2002: Kenji Noguchi; Katsuaki Kato; Takuya Moriya; Takashi Suzuki; Michiya Saito; Tohru Kikuchi; Jing Yang; Akira Imatani; Hitoshi Sekine; Shuichi Ohara; Takayoshi Toyota; Tooru Shimosegawa; Hironobu Sasano
Analysis of cell damage in Helicobacter pylori-associated gastritis.
Pathology international 2002;52(2):110-8.
2002: Atsushi Masamune; Kazuhiro Kikuta; Masahiro Satoh; Yoshitaka Sakai; Akihiko Satoh; Tooru Shimosegawa
Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells.
The Journal of biological chemistry 2002;277(1):141-7.
2002: Reishi Abe; Tooru Shimosegawa
Development of a bent-type tube stent for simultaneous drainage of bile and pancreatic juice.
Journal of hepato-biliary-pancreatic surgery 2002;9(5):600-2.
2002: Katsunori Iijima; Shuich Ohara; Tooru Shimosegawa
The role of inducible nitric oxide synthase in the relaxation of lower esophageal sphincter in septic state.
Journal of gastroenterology 2002;37(12):1090-1.
2002: Tooru Shimosegawa
Are glucocorticoids really useful for the treatment of acute pancreatitis?
Journal of gastroenterology 2002;37(7):580-1.
2002: Yoshitaka Sakai; Atsushi Masamune; Tohru Asakura; Tooru Shimosegawa; Kazunori Takeda; Mika Watanabe; Toshimitsu Suzuki
A patient with multiple endocrine neoplasia type 1 with a novel MEN1 gene mutation (237delC).
Journal of gastroenterology 2002;37(6):485-7.
2002: Akihiko Satoh; Kennichi Satoh; Atsushi Masamune; Tetsuya Yamagiwa; Tooru Shimosegawa
Activation of adenosine A2a receptor pathway reduces leukocyte infiltration but enhances edema formation in rat caerulein pancreatitis.
Pancreas 2002;24(1):75-82.
2002: Kenzo Kaneko; Kennichi Satoh; Atsushi Masamune; Akihiko Satoh; Tooru Shimosegawa
Myosin light chain kinase inhibitors can block invasion and adhesion of human pancreatic cancer cell lines.
Pancreas 2002;24(1):34-41.
2001: Y Kojima; Yoshitaka Kinouchi; Seiichi Takahashi; Kenichi Negoro; Nobuo Hiwatashi; Tooru Shimosegawa
Inflammatory bowel disease is associated with a novel promoter polymorphism of natural resistance-associated macrophage protein 1 (NRAMP1) gene.
Tissue antigens 2001;58(6):379-84.
2001: Hiroya Mizutamari; Atsushi Masamune; Tohru Asakura; Y Nagasaki; Akihiko Satoh; Yoshitaka Sakai; Tetsuya Yamagiwa; Tooru Shimosegawa
A case of hemosuccus pancreaticus associated with hereditary pancreatitis.
The Tohoku journal of experimental medicine 2001;195(3):191-5.
2001: T Sano; G Hirasawa; Junji Takeyama; Andrew Darnel; Takashi Suzuki; Takuya Moriya; K Kato; Hitoshi Sekine; Shuichi Ohara; Tooru Shimosegawa; J Nakamura; M Yoshihama; N Harada; Hironobu Sasano
17 beta-Hydroxysteroid dehydrogenase type 2 expression and enzyme activity in the human gastrointestinal tract.
Clinical science (London, England : 1979) 2001;101(5):485-91.
2001: K Satoh; K Kaneko; M Hirota; A Masamune; A Satoh; Tooru Shimosegawa
Tumor necrosis factor-related apoptosis-inducing ligand and its receptor expression and the pathway of apoptosis in human pancreatic cancer.
Pancreas 2001;23(3):251-8.
2001: Tooru Shimosegawa
[Pathobiology of severe acute pancreatitis].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2001;98(9):1029-36.
2001: A Masamune; Y Sakai; M Yoshida; A Satoh; K Satoh; Tooru Shimosegawa
Lysophosphatidylcholine activates transcription factor NF-kappaB and AP-1 in AR42J cells.
Digestive diseases and sciences 2001;46(9):1871-81.
2001: Tomoyuki Koike; Shuichi Ohara; Hitoshi Sekine; K Iijima; Y Abe; K Kato; T Toyota; Tooru Shimosegawa
Helicobacter pylori infection prevents erosive reflux oesophagitis by decreasing gastric acid secretion.
Gut 2001;49(3):330-4.
2001: Atsushi Masamune; M Yoshida; Y Sakai; Tooru Shimosegawa
Rebamipide inhibits ceramide-induced interleukin-8 production in Kato III human gastric cancer cells.
The Journal of pharmacology and experimental therapeutics 2001;298(2):485-92.
2001: Kennichi Satoh; K Kaneko; M Hirota; Atsushi Masamune; Akihiko Satoh; Tooru Shimosegawa
Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors.
Cancer 2001;92(2):271-8.
2001: Tomoyuki Koike; Shuichi Ohara; Hitoshi Sekine; K Iijima; K Kato; T Toyota; Tooru Shimosegawa
Increased gastric acid secretion after Helicobacter pylori eradication may be a factor for developing reflux oesophagitis.
Alimentary pharmacology & therapeutics 2001;15(6):813-20.
2001: Takaaki Abe; Michiaki Unno; Tohru Onogawa; Taro Tokui; T N Kondo; Rie Nakagomi; H Adachi; K Fujiwara; M Okabe; Takehiro Suzuki; Kazuo Nunoki; E Sato; M Kakyo; Toshiyuki Nishio; J Sugita; Naoki Asano; Masayuki Tanemoto; M Seki; F Date; K Ono; Y Kondo; Ken-ichi Shiiba; Masanori Suzuki; H Ohtani; Tooru Shimosegawa; K Iinuma; H Nagura; Sadayoshi Ito; Seiki Matsuno
LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.
Gastroenterology 2001;120(7):1689-99.
2001: M Fujita; A Masamune; A Satoh; Y Sakai; K Satoh; Tooru Shimosegawa
Ascites of rat experimental model of severe acute pancreatitis induces lung injury.
Pancreas 2001;22(4):409-18.
2001: K Fujiwara; H Adachi; Toshiyuki Nishio; Michiaki Unno; Taro Tokui; M Okabe; Tohru Onogawa; Takehiro Suzuki; Naoki Asano; Masayuki Tanemoto; M Seki; Ken-ichi Shiiba; Masanori Suzuki; Y Kondo; Kazuo Nunoki; Tooru Shimosegawa; K Iinuma; Sadayoshi Ito; Seiki Matsuno; Takaaki Abe
Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner.
Endocrinology 2001;142(5):2005-12.
2001: A Takasu; Tooru Shimosegawa; Eku Shimosegawa; J Hatazawa; Y Nagasaki; K Kimura; M Fujita; T Toyota
[11C]methionine positron emission tomography for the evaluation of pancreatic exocrine function in chronic pancreatitis.
Pancreas 2001;22(2):203-9.
2001: K Kaneko; Y Nagasaki; Toru Furukawa; Hiroya Mizutamari; A Sato; Atsushi Masamune; Tooru Shimosegawa; Akira Horii
Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis.
Journal of human genetics 2001;46(5):293-7.
2001: A Masamune; Y Sakai; A Satoh; M Fujita; M Yoshida; Tooru Shimosegawa
Lysophosphatidylcholine induces apoptosis in AR42J cells.
Pancreas 2001;22(1):75-83.
2000: K Komatsu; Tooru Shimosegawa; S Kikuchi; M Uchi; Y Maruhama; N Kisara; Yoshiyuki Ueno; T Toyota
Paradoxical progression of biliary strictures against recovery of biochemical parameters under ursodeoxycholic acid treatment in a case of primary sclerosing cholangitis with ulcerative colitis.
Internal medicine (Tokyo, Japan) 2000;39(12):1049-53.
2000: Kenichi Negoro; Seiichi Takahashi; Yoshitaka Kinouchi; Sho Takagi; Nobuo Hiwatashi; R Ichinohasama; Tooru Shimosegawa; T Toyota
Analysis of the PTEN gene mutation in polyposis syndromes and sporadic gastrointestinal tumors in Japanese patients.
Diseases of the colon and rectum 2000;43(10 Suppl):S29-33.
2000: Sho Takagi; Yoshitaka Kinouchi; Nobuo Hiwatashi; Fumio Nagashima; M Chida; Seiichi Takahashi; Kenichi Negoro; Tooru Shimosegawa; T Toyota
Relationship between microsatellite instability and telomere shortening in colorectal cancer.
Diseases of the colon and rectum 2000;43(10 Suppl):S12-7.
2000: A Satoh; Tooru Shimosegawa; K Satoh; H Ito; Y Kohno; A Masamune; M Fujita; T Toyota
Activation of adenosine A1-receptor pathway induces edema formation in the pancreas of rats.
Gastroenterology 2000;119(3):829-36.
2000: A Masamune; Tooru Shimosegawa; A Satoh; M Fujita; Y Sakai; T Toyota
Nitric oxide decreases endothelial activation by rat experimental severe pancreatitis-associated ascitic fluids.
Pancreas 2000;20(3):297-304.
2000: Yoshiyuki Ueno; Motoyasu Ishii; Kaichiro Yahagi; Y Mano; N Kisara; N Nakamura; Tooru Shimosegawa; T Toyota; S Nagata
Fas-mediated cholangiopathy in the murine model of graft versus host disease.
Hepatology (Baltimore, Md.) 2000;31(4):966-74.
2000: M Iwabuchi; Hironobu Sasano; N Hiwatashi; T Masuda; Tooru Shimosegawa; T Toyota; Hiroshi Nagura
Serrated adenoma: a clinicopathological, DNA ploidy, and immunohistochemical study.
Anticancer research 2000;20(2B):1141-7.
2000: A Masamune; Tooru Shimosegawa; M Fujita; A Satoh; M Koizumi; T Toyota
Ascites of severe acute pancreatitis in rats transcriptionally up-regulates expression of interleukin-6 and -8 in vascular endothelium and mononuclear leukocytes.
Digestive diseases and sciences 2000;45(2):429-37.
2000: K Komatsu; Tooru Shimosegawa; M Uchi; Y Maruhama; T Toyota
Erythropoietic protoporphyria with severe liver dysfunction and acute pancreatitis.
Journal of gastroenterology 2000;35(5):391-5.
2000: K Iijima; S Ohara; H Sekine; T Koike; K Kato; S Asaki; Tooru Shimosegawa; T Toyota
Changes in gastric acid secretion assayed by endoscopic gastrin test before and after Helicobacter pylori eradication.
Gut 2000;46(1):20-6.
1999: Tooru Shimosegawa; T Toyota
[Gastric inhibitory polypeptide (GIP)].
Nihon rinsho. Japanese journal of clinical medicine 1999;57 Suppl():357-9.
1999: Tooru Shimosegawa; T Toyota
[Neurotensin].
Nihon rinsho. Japanese journal of clinical medicine 1999;57 Suppl():74-7.
1999: T Hoshi; Hironobu Sasano; K Kato; Shuichi Ohara; Tooru Shimosegawa; T Toyota; H Nagura
Cell damage and proliferation in human gastric mucosa infected by Helicobacter pylori--a comparison before and after H pylori eradication in non-atrophic gastritis.
Human pathology 1999;30(12):1412-7.
1999: K Satoh; Tooru Shimosegawa; A Masamune; M Hirota; M Koizumi; T Toyota
Fas ligand is frequently expressed in human pancreatic duct cell carcinoma.
Pancreas 1999;19(4):339-45.
1999: Kenichi Negoro; Yoshitaka Kinouchi; Nobuo Hiwatashi; S Takahashi; S Takagi; J Satoh; Tooru Shimosegawa; T Toyota
Crohn's disease is associated with novel polymorphisms in the 5'-flanking region of the tumor necrosis factor gene.
Gastroenterology 1999;117(5):1062-8.
1999: Sho Takagi; Yoshitaka Kinouchi; Nobuo Hiwatashi; M Chida; Fumio Nagashima; Seiichi Takahashi; Kenichi Negoro; Tooru Shimosegawa; T Toyota
Telomere shortening and the clinicopathologic characteristics of human colorectal carcinomas.
Cancer 1999;86(8):1431-6.
1999: A Satoh; Tooru Shimosegawa; A Masamune; M Fujita; M Koizumi; T Toyota
Ascitic fluid of experimental severe acute pancreatitis modulates the function of peritoneal macrophages.
Pancreas 1999;19(3):268-75.
1999: Tooru Shimosegawa; T Toyota
[NO and pancreatic diseases].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 1999;96(8):923-32.
1999: A Masamune; Tooru Shimosegawa; O Masamune; N Mukaida; M Koizumi; T Toyota
Helicobacter pylori-dependent ceramide production may mediate increased interleukin 8 expression in human gastric cancer cell lines.
Gastroenterology 1999;116(6):1330-41.
1999: A Takasu; Tooru Shimosegawa; Eku Shimosegawa; J Hatazawa; K Kimura; M Fujita; M Koizumi; I Kanno; T Toyota
11C-methionine uptake to the pancreas and its secretion: a positron emission tomography study in humans.
Pancreas 1999;18(4):392-8.
1999: H Suzuki; Tooru Shimosegawa; S Ohara; T Toyota
Epalrestat prevents the decrease in gastric mucosal blood flow and protects the gastric mucosa in streptozotocin diabetic rats.
Journal of gastroenterology 1999;34(2):172-7.
1999: A Masamune; Tooru Shimosegawa; K Kimura; M Fujita; A Sato; M Koizumi; T Toyota
Specific induction of adhesion molecules in human vascular endothelial cells by rat experimental pancreatitis-associated ascitic fluids.
Pancreas 1999;18(2):141-50.
1999: A Satoh; Tooru Shimosegawa; M Fujita; K Kimura; A Masamune; M Koizumi; T Toyota
Inhibition of nuclear factor-kappaB activation improves the survival of rats with taurocholate pancreatitis.
Gut 1999;44(2):253-8.
1998: A Satoh; Tooru Shimosegawa; K Kimura; S Moriizumi; A Masamune; M Koizumi; T Toyota
Nitric oxide is overproduced by peritoneal macrophages in rat taurocholate pancreatitis: the mechanism of inducible nitric oxide synthase expression.
Pancreas 1998;17(4):402-11.
1998: A Takasu; Tooru Shimosegawa; S Fukudo; T Asakura; M Uchi; K Kimura; J Kashimura; K Satoh; M Koizumi; I Sasaki; Michio Hongo; T Suzuki; T Toyota
Duodenal gastrinoma--clinical features and usefulness of selective arterial secretin injection test.
Journal of gastroenterology 1998;33(5):728-33.
1998: R Abe; Tooru Shimosegawa; K Kimura; A Takasu; M Koizumi; T Toyota
Lipopolysaccharide-induced desensitization to pancreatic edema formation in rat cerulein pancreatitis.
Pancreas 1998;16(4):539-44.
1998: K Satoh; Tooru Shimosegawa; M Hirota; M Koizumi; T Toyota
Expression of transforming growth factor beta1 (TGFbeta1) and its receptors in pancreatic duct cell carcinoma and in chronic pancreatitis.
Pancreas 1998;16(4):468-74.
1998: K Kimura; Tooru Shimosegawa; H Sasano; R Abe; A Satoh; A Masamune; M Koizumi; H Nagura; T Toyota
Endogenous glucocorticoids decrease the acinar cell sensitivity to apoptosis during cerulein pancreatitis in rats.
Gastroenterology 1998;114(2):372-81.
1997: H Suzuki; Tooru Shimosegawa; A Satoh; K Kimura; S Ohara; S Asaki; T Toyota
Gastric mucosal blood flow response to stress in streptozotocin diabetic rats: regulatory role of nitric oxide.
Journal of gastroenterology 1997;32(6):726-33.
1997: T Meguro; Tooru Shimosegawa; A Satoh; H Suzuki; A Takasu; A Takayama; M Koizumi; T Toyota
Gallbladder emptying and cholecystokinin and pancreatic polypeptide responses to a liquid meal in patients with diabetes mellitus.
Journal of gastroenterology 1997;32(5):628-34.
1997: K Kimura; H Sasano; Tooru Shimosegawa; K Kato; T Noguchi; S Mochizuki; T Sawai; M Koizumi; T Toyota; H Nagura
Ultrastructural and confocal laser scanning microscopic examination of TUNEL-positive cells.
The Journal of pathology 1997;181(2):235-42.
1997: K Satoh; Tooru Shimosegawa; M Koizumi; T Toyota
Expression of CD44 in duct cell carcinomas and in intraductal neoplasms of the pancreas.
Anticancer research 1997;17(1A):215-9.